FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Preston, RJ
AF Preston, R. Julian
TI INTEGRATING BASIC RADIOBIOLOGICAL SCIENCE AND EPIDEMIOLOGICAL STUDIES:
WHY AND HOW
SO HEALTH PHYSICS
LA English
DT Article
DE National Council on Radiation Protection and Measurements; biological
indicators; epidemiology; risk analysis
ID DOSE-RESPONSE; IONIZING-RADIATION; RISK-ASSESSMENT; KEY EVENTS;
INCIDENCE CURVES; HEALTH-RISKS; CANCER-RISKS; EXPOSURE; MODE; CHILDHOOD
AB There is quite an extensive set of epidemiology studies conducted for a range of different radiation exposure scenarios and in some cases at doses that can be considered to be in the low dose range (< 100 mGy). In addition, there is an extensive literature on the effects of radiation at animal and cellular levels, as well as expanding knowledge of the underlying mechanisms of disease formation (both cancer and non-cancer). A significant concern is that these two areas of study have been linked rarely to support each other-to enhance low dose/low dose-rate extrapolation and reduction of uncertainty in risk estimates. Research should provide specific types of data to support the epidemiology and thereby enhance the radiation risk assessment process. Such an approach is one that can be adapted from that used for chemical exposures. It is based on the concept of adverse outcome pathways for the formation of adverse health outcomes. The adverse outcome pathway conceptual framework is considered to be a logical sequence of events (so-called key events) or processes within biological systems that can be used to understand adverse effects and refine the current risk assessment practice. This approach, which has only been used currently for chemicals, shifts the risk assessment focus from traditional apical endpoints (e.g., cancer and cardiovascular disease) to the development of a mechanistic understanding of effects at a molecular and cellular level. The need is to further the knowledge of the key events in radiation-induced diseases and to provide information on the dose and dose-rate response for these. It is proposed that the key-event approach be used in conjunction with enhanced radiation epidemiology data to reduce overall uncertainty in low dose/low dose-rate cancer and non-cancer risk estimates.
C1 US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Preston, RJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM preston.julian@epa.gov
NR 42
TC 8
Z9 8
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2015
VL 108
IS 2
BP 125
EP 130
DI 10.1097/HP.0000000000000224
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA AX6YN
UT WOS:000347064100007
PM 25551492
ER
PT J
AU Simon, SL
Braby, LA
Chang, PY
Goodhead, DT
Hora, S
Kocher, DC
Mabuchi, K
Puskin, JS
Richardson, D
Rosenstein, M
Tucker, J
Vano, E
AF Simon, Steven L.
Braby, Leslie A.
Chang, Polly Y.
Goodhead, Dudley T.
Hora, Stephen
Kocher, David C.
Mabuchi, Kiyohiko
Puskin, Jerome S.
Richardson, David
Rosenstein, Marvin
Tucker, James
Vano, Eliseo
TI BIOLOGICAL EFFECTIVENESS OF PHOTONS AND ELECTRONS AS A FUNCTION OF
ENERGY
SO HEALTH PHYSICS
LA English
DT Article
DE National Council on Radiation Protection and Measurements; cancer;
radiation risk; relative biological effectiveness
C1 [Simon, Steven L.; Mabuchi, Kiyohiko] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Braby, Leslie A.] Texas A&M Univ, Dept Nucl Engn, College Stn, TX 77843 USA.
[Chang, Polly Y.] SRI Int, Menlo Pk, CA 94025 USA.
[Goodhead, Dudley T.] MRC, Harwell OX11 0RD, Berks, England.
[Hora, Stephen] Univ So Calif, Ctr Risk & Econ Anal Terrorism Events, Los Angeles, CA 90089 USA.
[Kocher, David C.] Oak Ridge Ctr Risk Anal, Oak Ridge, TN 37830 USA.
[Puskin, Jerome S.] US EPA, Washington, DC 20460 USA.
[Richardson, David] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.
[Tucker, James] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA.
[Vano, Eliseo] Univ Complutense, Dept Radiol, Sch Med, E-28040 Madrid, Spain.
RP Simon, SL (reprint author), NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
EM ssimon@mail.nih.gov
NR 3
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2015
VL 108
IS 2
BP 143
EP 144
DI 10.1097/HP.0000000000000256
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA AX6YN
UT WOS:000347064100009
PM 25551494
ER
PT J
AU Boyd, MA
AF Boyd, Michael A.
TI US RADIATION PROTECTION: ROLE OF NATIONAL AND INTERNATIONAL
RECOMMENDATIONS AND OPPORTUNITIES FOR COLLABORATION (HARMONY, NOT
DISSONANCE)
SO HEALTH PHYSICS
LA English
DT Article
DE National Council on Radiation Protection and Measurements; International
Commission on Radiological Protection; radiation protection; safety
standards
AB For much of the 20th century, U.S. radiation protection policies were similar to those elsewhere in the world, in large part because the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) were closely aligned. In the 1970s, several U.S. regulations were released at about the same time as the 1977 recommendations from ICRP. The regulatory development process in the United States can be lengthy with ample opportunities for public involvement. While such deliberation is essential and beneficial, the rulemaking process does not lend itself to making frequent technical updates to rules. For this reason, many of the current radiation protection regulations in the United States are out of step with current recommendations of the ICRP and NCRP. The U.S. Nuclear Regulatory Commission and the U.S. Environmental Protection Agency are considering updates to important radiation protection regulations. These regulatory development actions could present the United States with an opportunity for incorporating the latest science into the U.S. system of radiation protection and provide for consideration of the latest recommendations of ICRP and NCRP. In particular, a revision of the recommendations in NCRP Report No. 116 (Limitation of Exposure to Ionizing Radiation) could provide U.S. agencies with useful advice to be considered in these rulemakings.
C1 US EPA, Washington, DC 20460 USA.
RP Boyd, MA (reprint author), US EPA, Ariel Rios Bldg,Mail Code 6608J,1200 Penn Ave NW, Washington, DC 20460 USA.
EM boyd.mike@epa.gov
NR 22
TC 1
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2015
VL 108
IS 2
BP 278
EP 282
DI 10.1097/HP.0000000000000236
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA AX6YN
UT WOS:000347064100024
PM 25551510
ER
PT J
AU Cyphert, JM
Carlin, DJ
Nyska, A
Schladweiler, MC
Ledbetter, AD
Shannahan, JH
Kodavanti, UP
Gavett, SH
AF Cyphert, Jaime M.
Carlin, Danielle J.
Nyska, Abraham
Schladweiler, Mette C.
Ledbetter, Allen D.
Shannahan, Jonathan H.
Kodavanti, Urmila P.
Gavett, Stephen H.
TI Comparative Long-Term Toxicity of Libby Amphibole and Amosite Asbestos
in Rats After Single or Multiple Intratracheal Exposures
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID FISCHER-344 RATS; MALIGNANT MESOTHELIOMA; MONTANA; VERMICULITE; DISEASE;
LUNG; FERROACTINOLITE; CARCINOGENICITY; INSTILLATION; INHALATION
AB In former mine workers of Libby, MT, exposure to amphibole-containing vermiculite was linked to increased rates of asbestosis, lung cancer, and mesothelioma. Although many studies showed adverse effects following exposure to Libby amphibole (LA; a mixture of winchite, richterite, and tremolite), little is known regarding the relative toxicity of LA compared to regulated asbestos, or regarding the risks associated with acute high-dose exposures relative to repeated low-dose exposures. In this study, pulmonary function, inflammation, and pathology were assessed after single or multiple intratracheal (IT) exposures of LA or a well-characterized amosite (AM) control fiber with equivalent fiber characteristics. Male F344 rats were exposed to an equivalent total mass dose (0.15, 0.5, 1.5, or 5 mg/rat) of LA or AM administered either as a single IT instillation, or as multiple IT instillations given every other week over a 13-wk period, and necropsied up to 20 mo after the initial IT. When comparing the two fiber types, in both studies LA resulted in greater acute neutrophilic inflammation and cellular toxicity than equal doses of AM, but long-term histopathological changes were approximately equivalent between fibers, suggesting that LA is at least as toxic as AM. In addition, although no dose-response relationship was discerned, mesothelioma or lung carcinomas were found after exposure to low and high dose levels of LA or AM in both studies. Conversely, when comparing studies, an equal mass dose given over multiple exposures instead of a single bolus resulted in greater chronic pathological changes in lung at lower doses, despite the initially weaker acute inflammatory response. Overall, these results suggest that there is a possibility of greater long-term pathological changes with repeated lower LA dose exposures, which more accurately simulates chronic environmental exposures.
C1 [Cyphert, Jaime M.] Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC USA.
[Cyphert, Jaime M.; Carlin, Danielle J.; Nyska, Abraham] NIEHS, NIH, Res Triangle Pk, NC 27709 USA.
[Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, Timrat, Israel.
[Schladweiler, Mette C.; Ledbetter, Allen D.; Kodavanti, Urmila P.; Gavett, Stephen H.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Shannahan, Jonathan H.] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO USA.
RP Gavett, SH (reprint author), US EPA, DABT, Mail Drop B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Gavett.stephen@epa.gov
FU U.S. EPA/University of North Carolina Toxicology Research Program
Training Agreement [CR 933237, 83515201-0]
FX This work was supported by a U.S. EPA/University of North Carolina
Toxicology Research Program Training Agreement (CR 933237 and
83515201-0). The authors thank Judy Richards for assistance with
biochemical analysis, and Drs. David Berry, Ian Gilmour, Maureen Gwinn,
Gary Hatch, and Ronald Hines for manuscript review.
NR 35
TC 7
Z9 7
U1 2
U2 18
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PD FEB 1
PY 2015
VL 78
IS 3
BP 151
EP 165
DI 10.1080/15287394.2014.947455
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AW5YC
UT WOS:000346345800001
PM 25506632
ER
PT J
AU Hu, L
Montzka, SA
Miller, JB
Andrews, AE
Lehman, SJ
Miller, BR
Thoning, K
Sweeney, C
Chen, HL
Godwin, DS
Masarie, K
Bruhwiler, L
Fischer, ML
Biraud, SC
Torn, MS
Mountain, M
Nehrkorn, T
Eluszkiewicz, J
Miller, S
Draxler, RR
Stein, AF
Hall, BD
Elkins, JW
Tans, PP
AF Hu, Lei
Montzka, Stephen A.
Miller, John B.
Andrews, Aryln E.
Lehman, Scott J.
Miller, Benjamin R.
Thoning, Kirk
Sweeney, Colm
Chen, Huilin
Godwin, David S.
Masarie, Kenneth
Bruhwiler, Lori
Fischer, Marc L.
Biraud, Sebastien C.
Torn, Margaret S.
Mountain, Marikate
Nehrkorn, Thomas
Eluszkiewicz, Janusz
Miller, Scot
Draxler, Roland R.
Stein, Ariel F.
Hall, Bradley D.
Elkins, James W.
Tans, Pieter P.
TI US emissions of HFC-134a derived for 2008-2012 from an extensive
flask-air sampling network
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
DE HFC-134a; emissions; inverse modeling; atmosphere based; US
ID ATMOSPHERIC OBSERVATIONS; EUROPEAN EMISSIONS; TRANSPORT MODELS; GLOBAL
EMISSIONS; INVERSION METHOD; UNITED-STATES; STILT MODEL; PART 1; CO2;
PERSPECTIVE
AB U.S. national and regional emissions of HFC-134a are derived for 2008-2012 based on atmospheric observations from ground and aircraft sites across the U.S. and a newly developed regional inverse model. Synthetic data experiments were first conducted to optimize the model assimilation design and to assess model-data mismatch errors and prior flux error covariances computed using a maximum likelihood estimation technique. The synthetic data experiments also tested the sensitivity of derived national and regional emissions to a range of assumed prior emissions, with the goal of designing a system that was minimally reliant on the prior. We then explored the influence of additional sources of error in inversions with actual observations, such as those associated with background mole fractions and transport uncertainties. Estimated emissions of HFC-134a range from 52 to 61 Gg yr(-1) for the contiguous U.S. during 2008-2012 for inversions using air transport from Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model driven by the 12km resolution meteorogical data from North American Mesoscale Forecast System (NAM12) and all tested combinations of prior emissions and background mole fractions. Estimated emissions for 2008-2010 were 20% lower when specifying alternative transport from Stochastic Time-Inverted Lagrangian Transport (STILT) model driven by the Weather Research and Forecasting (WRF) meteorology. Our estimates (for HYSPLIT-NAM12) are consistent with annual emissions reported by U.S. Environmental Protection Agency for the full study interval. The results suggest a 10-20% drop in U.S. national HFC-134a emission in 2009 coincident with a reduction in transportation-related fossil fuel CO2 emissions, perhaps related to the economic recession. All inversions show seasonal variation in national HFC-134a emissions in all years, with summer emissions greater than winter emissions by 20-50%.
C1 [Hu, Lei; Miller, John B.; Miller, Benjamin R.; Sweeney, Colm] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
[Hu, Lei; Montzka, Stephen A.; Miller, John B.; Andrews, Aryln E.; Miller, Benjamin R.; Thoning, Kirk; Sweeney, Colm; Masarie, Kenneth; Bruhwiler, Lori; Hall, Bradley D.; Elkins, James W.; Tans, Pieter P.] NOAA, Global Monitoring Div, Earth Syst Res Lab, Boulder, CO USA.
[Lehman, Scott J.] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA.
[Chen, Huilin] Univ Groningen, Ctr Isotope Res, Groningen, Netherlands.
[Godwin, David S.] US EPA, Alternat & Emiss Reduct Branch, Stratospher Protect Div, Off Atmospher Programs,Off Air & Radiat, Washington, DC 20460 USA.
[Fischer, Marc L.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Environm Energy Technol Div, Berkeley, CA 94720 USA.
[Biraud, Sebastien C.; Torn, Margaret S.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA.
[Mountain, Marikate; Nehrkorn, Thomas; Eluszkiewicz, Janusz] Atmospher & Environm Res, Lexington, MA USA.
[Miller, Scot] Harvard Univ, Dept Earth & Planetary Sci, Cambridge, MA 02138 USA.
[Draxler, Roland R.; Stein, Ariel F.] NOAA, Air Resources Lab, College Pk, MD USA.
RP Hu, L (reprint author), Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
EM lei.hu@colorado.edu; stephen.a.montzka@noaa.gov
RI Torn, Margaret/D-2305-2015; Andrews, Arlyn/K-3427-2012; Chen,
Huilin/J-9479-2012; Stein, Ariel F/L-9724-2014; Biraud,
Sebastien/M-5267-2013
OI Chen, Huilin/0000-0002-1573-6673; Stein, Ariel F/0000-0002-9560-9198;
Montzka, Stephen/0000-0002-9396-0400; Nehrkorn,
Thomas/0000-0003-0637-3468; Biraud, Sebastien/0000-0001-7697-933X
FU NOAA Climate Program Office's Atmospheric Chemistry, Carbon Cycle, and
Climate (AC4) program - North American Carbon Program; California Energy
Commission; California Air Resources Board [DE-AC02-05CH11231]; U.S.
Department of Energy, Office of Science, Atmospheric Radiation
Measurement Program [DE-AC02-05CH11231]; U.S. Department of Energy,
Office of Science, Office of Biological and Environmental Research
[DE-AC02-05CH11231]; NOAA's Climate Program Office under the
CarbonTracker-Lagrange project
FX This work was performed while one of us (LH) was a National Research
Council postdoctoral fellow and was funded in part by NOAA Climate
Program Office's Atmospheric Chemistry, Carbon Cycle, and Climate (AC4)
program in support of the North American Carbon Program. Flask sampling
at the WGC and STR towers were partially supported by a California
Energy Commission and the California Air Resources Board grants to LBNL
under contract DE-AC02-05CH11231, while aircraft sampling above the SGP
site was supported by the U.S. Department of Energy, Office of Science,
Atmospheric Radiation Measurement Program and Office of Biological and
Environmental Research, both underx U.S. Department of Energy contract
DE-AC02-05CH11231. WRF-STILT runs were supported by NOAA's Climate
Program Office under the CarbonTracker-Lagrange project. This inversion
analysis was conducted using the high performance computing system in
the NOAA Environmental Security Computing Center, located in Fairmont,
West Virginia, USA. We thank A. Jacobson and S. Basu for useful
discussions related to inversion problems. We thank C. Siso, D. Mondeel,
P. M. Lang, J. Higgs, M. Crotwell, S. Wolter, D. Neff, J. Kofler, and
others involved with flask analysis and the large team of collaborators
associated with operation, maintenance, and logistics of NOAA's
Cooperative U.S.- and global-scale Greenhouse Gas Reference flask
sampling networks. Measured atmospheric mole fractions of HFC-134a and
calculated footprints used in this analysis can be downloaded at
NOAA/ESRL/GMD website
(http://www.esrl.noaa.gov/gmd/hats/gases/HFC134a.html).
NR 68
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U1 2
U2 16
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD JAN 27
PY 2015
VL 120
IS 2
BP 801
EP 825
DI 10.1002/2014JD022617
PG 25
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CC1QQ
UT WOS:000350117100026
ER
PT J
AU Willson, SA
AF Willson, Stuart A.
TI Investigation of the Persistence of Nerve Agent Degradation Analytes on
Surfaces through Wipe Sampling and Detection with Ultrahigh Performance
Liquid Chromatography-Tandem Mass Spectrometry
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID CHEMICAL WARFARE AGENTS; HYDROLYSIS PRODUCTS; PESTICIDES; MATRICES;
SARIN; FATE; VX
AB The persistence of chemical warfare nerve agent degradation analytes on surfaces is important, from indicating the presence of nerve agent on a surface to guiding environmental restoration of a site after a release. Persistence was investigated for several chemical warfare nerve agent degradation analytes on indoor surfaces and presents an approach for wipe sampling of surfaces, followed by wipe extraction and liquid chromatographytandem mass spectrometry detection. Commercially available wipe materials were investigated to determine optimal wipe recoveries. Tested surfaces included porous/permeable (vinyl tile, painted drywall, and wood) and largely nonporous/impermeable (laminate, galvanized steel, and glass) surfaces. Wipe extracts were analyzed by ultrahigh performance liquid chromatographytandem mass spectrometry (UPLCMS/MS). UPLC provides a separation of targeted degradation analytes in addition to being nearly four times faster than high-performance liquid chromatography, allowing for greater throughput after a large-scale contamination incident and subsequent remediation events. Percent recoveries from nonporous/impermeable surfaces were 60103% for isopropyl methylphosphonate (IMPA), GB degradate; 6191% for ethyl methylphosphonate (EMPA), VX degradate; and 6098% for pinacolyl methylphosphonate (PMPA), GD degradate. Recovery efficiencies for methyl phosphonate (MPA), nerve agent degradate, and ethylhydrogen dimethylphosphonate (EHDMAP), GA degradate, were lower, perhaps due to matrix effects. Diisopropyl methylphosphonate, GB impurity, was not recovered from surfaces. The resulting detection limits for wipe extracts were 0.065 ng/cm(2) for IMPA, 0.079 ng/cm(2) for MPA, 0.040 ng/cm(2) for EMPA, 0.078 ng/cm(2) for EHDMAP, and 0.013 ng/cm(2) for PMPA. The data indicate that laboratories may hold wipe samples for up to 30 days prior to analysis. Target analytes were observed to persist on surfaces for at least 6 weeks.
C1 US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Willson, SA (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
EM Willison.stuart@epa.gov
FU U.S. Environmental Protection Agency (EPA) through Office of Research
and Development under EPA IA [DW-75-922440001-0]; National Institute for
Occupational Safety and Health (NIOSH) through Centers for Disease
Control and Prevention
FX The U.S. Environmental Protection Agency (EPA) through its Office of
Research and Development funded and managed the research described
herein under EPA IA no. DW-75-922440001-0 with the National Institute
for Occupational Safety and Health (NIOSH) through its Centers for
Disease Control and Prevention. It has been reviewed by the Agency but
does not necessarily reflect the Agency's views. No official endorsement
should be inferred. EPA does not endorse the purchase or sale of any
commercial products or services.
NR 35
TC 3
Z9 3
U1 3
U2 22
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD JAN 20
PY 2015
VL 87
IS 2
BP 1034
EP 1041
DI 10.1021/ac503777z
PG 8
WC Chemistry, Analytical
SC Chemistry
GA AZ6LX
UT WOS:000348332300030
PM 25495198
ER
PT J
AU Sekine, R
Brunetti, G
Donner, E
Khaksar, M
Vasilev, K
Jamting, AK
Scheckel, KG
Kappen, P
Zhang, H
Lombi, E
AF Sekine, R.
Brunetti, G.
Donner, E.
Khaksar, M.
Vasilev, K.
Jaemting, A. K.
Scheckel, K. G.
Kappen, P.
Zhang, H.
Lombi, E.
TI Speciation and Lability of Ag-, AgCl-, and Ag2S-Nanoparticles in Soil
Determined by X-ray Absorption Spectroscopy and Diffusive Gradients in
Thin Films
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SILVER SULFIDE NANOPARTICLES; WASTE-WATER; SEWAGE-SLUDGE; ENVIRONMENTAL
TRANSFORMATIONS; ENGINEERED NANOMATERIALS; IN-SITU; TOXICITY; FATE;
BEHAVIOR; LIGANDS
AB Long-term speciation and lability of silver (Ag-), silver chloride (AgCl-), and silver sulfide nanoparticles (Ag2S-NPs) in soil were studied by X-ray absorption spectroscopy (XAS), and newly developed nano Diffusive Gradients in Thin Films (DGT) devices. These nano-DGT devices were designed specifically to avoid confounding effects when measuring element lability in the presence of nanoparticles. The aging profile and stabilities of the three nanoparticles and AgNO3 (ionic Ag) in soil were examined at three different soil pH values over a period of up to 7 months. Transformation of ionic Ag, Ag-NP and AgCl-NPs were dependent on pH. AgCl formation and persistence was observed under acidic conditions, whereas sulfur-bound forms of Ag dominated in neutral to alkaline soils. Ag2S-NPs were found to be very stable under all conditions tested and remained sulfur bound after 7 months of incubation. Ag lability was characteristically low in soils containing Ag2S-NPs. Other forms of Ag were linked to higher DGT-determined lability, and this varied as a function of aging and related speciation changes as determined by XAS. These results clearly indicate that Ag2S-NPs, which are the most environmentally relevant form of Ag that enter soils, are chemically stable and have profoundly low Ag lability over extended periods. This may minimize the long-term risks of Ag toxicity in the soil environment.
C1 [Sekine, R.; Brunetti, G.; Donner, E.; Lombi, E.] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes Campus, SA 5095, Australia.
[Khaksar, M.; Vasilev, K.] Univ S Australia, Mawson Inst, Mawson Lakes Campus, SA 5095, Australia.
[Jaemting, A. K.] Natl Measurement Inst, Lindfield, NSW 2070, Australia.
[Scheckel, K. G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA.
[Kappen, P.] Australian Synchrotron, Clayton, Vic 3168, Australia.
[Zhang, H.] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England.
RP Sekine, R (reprint author), Univ S Australia, Ctr Environm Risk Assessment & Remediat, Bldg 10, Mawson Lakes Campus, SA 5095, Australia.
EM Ryo.Sekine@unisa.edu.au
RI Sekine, Ryo/F-3721-2013; ID, MRCAT/G-7586-2011; Zhang, Hao/E-5375-2010;
Donner, Erica/A-4809-2012; Lombi, Enzo/F-3860-2013
OI Scheckel, Kirk/0000-0001-9326-9241; Sekine, Ryo/0000-0001-9980-0603;
Donner, Erica/0000-0001-6465-2233; Lombi, Enzo/0000-0003-3384-0375
FU Australian Research Council Future Fellowship [FT100100337, FT100100292,
FT130101003]; Australian Research Council [DP120101115]; DOE Office of
Science by Argonne National Laboratory [DE-AC02-06CH11357]; EPA;
Australian Synchrotron
FX E.L., K.V., and E.D. are recipients of Australian Research Council
Future Fellowship FT100100337, FT100100292, and FT130101003,
respectively. The funding support from the Australian Research Council
Discovery Project DP120101115 is gratefully acknowledged. We thank Dr
Hamid M. Pouran for his assistance with the Nano-DGT devices. The
Australian Synchrotron is acknowledged for the beamtime on the X-ray
Absorption Spectroscopy Beamline (AS132 XAS6663a and XAS6663b),
associated travel funding, and Dr. Bernt Johannessen and Dr. Chris
Glover for assistance during the beamtime. The software tool "Sakura"
was developed at the Australian Synchrotron in partnership with the
National eResearch Collaborative Tools and Resources (NeCTAR) project.
MRCAT operations are supported by the Department of Energy and the MRCAT
member-institutions. This research used resources of the Advanced Photon
Source, a U.S. Department of Energy (DOE) Office of Science User
Facility operated for the DOE Office of Science by Argonne National
Laboratory under Contract No. DE-AC02-06CH11357. Although EPA
contributed to this article, the research presented was not performed by
or funded by EPA and was not subject to EPA's quality system
requirements. Consequently, the views, interpretations, and conclusions
expressed in this article are solely those of the authors and do not
necessarily reflect or represent EPA's views or policies.
NR 50
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Z9 17
U1 15
U2 101
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 20
PY 2015
VL 49
IS 2
BP 897
EP 905
DI 10.1021/es504229h
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AZ6LY
UT WOS:000348332400026
PM 25436975
ER
PT J
AU Washington, JW
Jenkins, TM
Rankin, K
Naile, JE
AF Washington, John W.
Jenkins, Thomas M.
Rankin, Keegan
Naile, Jonathan E.
TI Decades-Scale Degradation of Commercial, Side-Chain, Fluorotelomer-Based
Polymers in Soils and Water
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SLUDGE-APPLIED SOILS; DEGRADABILITY; PERSISTENCE; ALCOHOLS; ALABAMA;
DECATUR; USA
AB Fluorotelomer-based polymers (FTPs) are the primary product of the fluorotelomer industry. Here we report on a 376-day study of the degradability of two commercial acrylate-linked FTPs in four saturated soils and in water. Using an exhaustive serial extraction, we report GC/MS and LC/MS/MS results for 50 species including fluorotelomer alcohols and acids, and perfluorocarboxylates. Modeling of seven sampling rounds, each consisting of >= 5 replicate microcosm treatments, for one commercial FTP in one soil yielded half-life estimates of 65-112 years and, when the other commercial FTP and soils were evaluated, the estimated half-lives ranged from 33 to 112 years. Experimental controls, consisting of commercial FTP in water, degraded roughly at the same rate as in soil. A follow-up experiment, with commercial FTP in pH 10 water, degraded roughly 10-fold faster than the circum-neutral control suggesting that commercial FTPs can undergo OH-mediated hydrolysis. 8:2Fluorotelomer alcohol generated from FTP degradation in soil was more stable than without FTP present suggesting a clathrate guest-host association with the FTP. To our knowledge, these are the only degradability-test results for commercial FTPs that have been generated using exhaustive extraction procedures. They unambiguously show that commercial FTPs, the primary product of the fluorotelomer industry, are a source of fluorotelomer and perfluorinated compounds to the environment.
C1 [Washington, John W.; Naile, Jonathan E.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Jenkins, Thomas M.] Senior Environm Employment Program, Athens, GA 30605 USA.
[Rankin, Keegan] Univ Toronto, Dept Chem, Toronto, ON 141119, Canada.
RP Washington, JW (reprint author), US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
EM Washington.john@epa.gov
FU USEPA Office of Research Development; Office of Pollution Prevention
Toxics
FX This research was funded by the USEPA Office of Research & Development
and Office of Pollution Prevention & Toxics. We thank Greg Fritz, Jack
Jones, Laurence Libelo, David Lynch and Eric Weber, all of the EPA, and
the editor and manuscript reviewers for insightful comments. We thank
Chrys Wesdemiotis (University of Akron) for the opportunity to analyze
samples by MALDI-TOF. Views expressed in this paper do not necessarily
represent the views or policies of the USEPA. Mention of trade names or
products does not convey EPA approval, endorsement or recommendation.
The authors declare no competing financial interest.
NR 28
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U1 6
U2 28
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 20
PY 2015
VL 49
IS 2
BP 915
EP 923
DI 10.1021/es504347u
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AZ6LY
UT WOS:000348332400028
PM 25426868
ER
PT J
AU Watkins, AM
Wood, CR
Lin, MT
Abbott, BD
AF Watkins, Andrew M.
Wood, Carmen R.
Lin, Mimi T.
Abbott, Barbara D.
TI The effects of perfluorinated chemicals on adipocyte differentiation in
vitro
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE PFOA; PFNA; PFHxS; PFOS; PPAR; Adipocyte
ID ACTIVATED-RECEPTOR-ALPHA; PERFLUOROOCTANOIC ACID; PERFLUOROALKYL ACIDS;
PPAR-ALPHA; DEVELOPMENTAL TOXICITY; NUCLEAR RECEPTORS; FATTY-ACIDS;
MOUSE; ADIPOGENESIS; ENDOCRINE
AB The 3T3-L1 preadipocyte culture system has been used to examine numerous compounds that influence adipocyte differentiation or function. The perfluoroalkyl acids (PFAAs), used as surfactants in a variety of industrial applications, are of concern as environmental contaminants that are detected worldwide in human serum and animal tissues. This study was designed to evaluate the potential for PFAAs to affect adipocyte differentiation and lipid accumulation using mouse 3T3-L1 cells. Cells were treated with perfluorooctanoic acid (PFOA) (5-1001.1,M), perfluorononanoic acid (PFNA) (5-10012M), perfluorooctane sulfonate (PFOS) (50-300 iM), perfluorohexane sulfonate (PFHxS) (40-250 IiM), the peroxisome proliferator activated receptor (PPAR) PPARa agonist Wyeth-14,643 (WY-14,643), and the PPARy agonist rosiglitazone. The PPARy agonist was included as a positive control as this pathway is critical to adipocyte differentiation. The PPARa agonist was included as the PFAA compounds are known activators of this pathway. Cells were assessed morphometrically and biochemically for number, size, and lipid content. RNA was extracted for qPCR analysis of 13 genes selected for their importance in adipocyte differentiation and lipid metabolism. There was a significant concentration-related increase in cell number and decreased cell size after exposure to PFOA, PFHxS, PFOS, and PFNA. All four PFAA treatments produced a concentrationrelated decrease in the calculated average area occupied by lipid per cell. However, total triglyceride levels per well increased with a concentration-related trend for all compounds, likely due to the increased cell number. Expression of mRNA for the selected genes was affected by all exposures and the specific impacts depended on the particular compound and concentration. Acox1 and Gapdh were upregulated by all six compounds. The strongest overall effect was a nearly 10-fold induction of Scdl by PFHxS. The sulfonated PFAAs-produced numerous, strong-changes in gene expression similar to the effects after treatment with the PPARy agonist rosiglitazone. By comparison, the effects on gene expression were muted for the carboxylated PFAAs and for the PPARa agonist WY-14,643. In summary, all perfluorinated compounds increased cell number, decreased cell size, increased total triglyceride, and altered expression of genes associated with adipocyte differentiation and lipid metabolism. Published by Elsevier Ireland Ltd.
C1 [Watkins, Andrew M.; Wood, Carmen R.; Lin, Mimi T.; Abbott, Barbara D.] US EPA, Dev Toxicol Branch, Natl Hlth & Environm Effects Res Lab, Toxic Assessment Div,Off Res & Dev, Res Triangle Pk, NC 27709 USA.
RP Watkins, AM (reprint author), US EPA, NHEERL TAD DTB, MD-B105-04, Res Triangle Pk, NC 27709 USA.
EM watkins.andrew@epa.gov
NR 41
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U1 9
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2015
VL 400
IS C
BP 90
EP 101
DI 10.1016/j.mce.2014.10.020
PG 12
WC Cell Biology; Endocrinology & Metabolism
SC Cell Biology; Endocrinology & Metabolism
GA CA3SJ
UT WOS:000348826100010
PM 25448844
ER
PT J
AU Moser, VC
Stewart, N
Freeborn, DL
Crooks, J
MacMillan, DK
Hedge, JM
Wood, CE
McMahen, RL
Strynar, MJ
Herr, DW
AF Moser, Virginia C.
Stewart, Nicholas
Freeborn, Danielle L.
Crooks, James
MacMillan, Denise K.
Hedge, Joan M.
Wood, Charles E.
McMahen, Rebecca L.
Strynar, Mark J.
Herr, David W.
TI Assessment of serum biomarkers in rats after exposure to pesticides of
different chemical classes
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Biomarkers; Cytokines; Metabolomics; Hormones; Pesticides
ID DISCRIMINANT-ANALYSIS; SELECTIVE TOXICITY; VARIABLE SELECTION; FIPRONIL
SULFONE; INSECTICIDES; RECEPTORS; CYTOKINES; SYSTEM; BIOSYNTHESIS;
METABOLISM
AB There is increasing emphasis on the use of biomarkers of adverse outcomes in safety assessment and translational research. We evaluated serum biomarkers and targeted metabolite profiles after exposure to pesticides (permethrin, deltamethrin, imidacloprid, carbaryl, triadimefon, fipronil) with different neurotoxic actions. Adult male Long Evans rats were evaluated after single exposure to vehicle or one of two doses of each pesticide at the time of peak effect. The doses were selected to produce similar magnitude of behavioral effects across chemicals. Serum or plasma was analyzed using commercial cytokine/protein panels and targeted metabolomics. Additional studies of fipronil used lower doses (lacking behavioral effects), singly or for 14 days, and included additional markers of exposure and biological activity. Biomarker profiles varied in the number of altered analytes and patterns of change across pesticide classes, and discriminant analysis could separate treatment groups from control. Low doses of fipronil produced greater effects when given for 14 days compared to a single dose. Changes in thyroid hormones and relative amounts of fipronil and its sulfone metabolite also differed between the dosing regimens. Most cytokine changes reflected alterations in inflammatory responses, hormone levels, and products of phospholipid, fatty acid, and amino acid metabolism. These findings demonstrate distinct blood-based analyte profiles across pesticide classes, dose levels, and exposure duration. These results show promise for detailed analyses of these biomarkers and their linkages to biological pathways. Published by Elsevier Inc.
C1 [Moser, Virginia C.; Stewart, Nicholas; Freeborn, Danielle L.; Herr, David W.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxidty Assessment Div,Neurotoxicol Branch, Res Triangle Pk, NC 27711 USA.
[Crooks, James; MacMillan, Denise K.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Analyt Chem Res Core,Res Cores Unit, Res Triangle Pk, NC 27711 USA.
[Hedge, Joan M.; Wood, Charles E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[McMahen, Rebecca L.; Strynar, Mark J.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA.
RP Moser, VC (reprint author), US EPA, MD B105-04, Res Triangle Pk, NC 27711 USA.
EM Moser.ginger@epa.gov
FU Office of Research and Development, U.S. Environmental Protection Agency
FX The authors gratefully acknowledge the assistance of Ms Judy Richards
for liver enzyme assays, and Drs Steve Edwards and Brian Chorley for
their review of this manuscript. This research was funded by the
intramural research program of the Office of Research and Development,
U.S. Environmental Protection Agency.
NR 53
TC 9
Z9 11
U1 4
U2 34
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 15
PY 2015
VL 282
IS 2
BP 161
EP 174
DI 10.1016/j.taap.2014.11.016
PG 14
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CA8UC
UT WOS:000349195400005
PM 25497286
ER
PT J
AU Freeborn, DL
McDaniel, KL
Moser, VC
Herr, DW
AF Freeborn, Danielle L.
McDaniel, Katherine L.
Moser, Virginia C.
Herr, David W.
TI Use of electroencephalography (EEG) to assess CNS changes produced by
pesticides with different modes of action: Effects of permethrin,
deltamethrin, fipronil, imidacloprid, carbaryl, and triadimefon
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE EEG; Pesticides; Rats
ID ACETYLCHOLINESTERASE INHIBITOR CHLORPYRIFOS; SENSORY EVOKED-POTENTIALS;
POWER SPECTRA; PYRETHROID INSECTICIDES; TRIAZOLE FUNGICIDE;
PSYCHOPHYSIOLOGICAL RESEARCH; INDUCED CHOREOATHETOSIS; CHOLINESTERASE
ACTIVITY; ALZHEIMERS-DISEASE; SELECTIVE TOXICITY
AB The electroencephalogram (EEG) is an apical measure, capable of detecting changes in brain neuronal activity produced by internal or external stimuli. We assessed whether pesticides with different modes of action produced different changes in the EEG of adult male Long-Evans rats. The EEG was recorded using two montages (visual cortex referenced to the cerebellum and to the frontal cortex) in unrestrained rats at the time of peak behavioral effects. Pesticides included: permethrin and deltamethrin (Type land Type II pyrethroids; 2 h), fipronil (single and repeated doses; phenylpyrazole; 6 h), imidacloprid (neonicotinoid; 2 h), carbaryl (carbamate; 0.5 h), and triadimefon (triazole; 1 h), using dosages that produced approximately an ED30 or an ED50-ED80 change in motor activity. Permethrin (43, 100 mg/kg) increased amplitudes or areas (delta, alpha, or gamma bands) in the EEG. Deltamethrin (2.5, 5.5 mg/kg) reduced the amplitudes or areas of the delta, theta, alpha, beta, and gamma bands, but the changes were not dose-related. A single treatment with fipronil (25, 50 mg/kg, but not 5, 10 mg/kg) decreased gamma band area. Additional changes in the delta, theta, and gamma bands were observed when fipronil (5, 10 mg/kg) was administered for 14 days. Imidacloprid (50, 100 mg/kg) did not alter the EEG. Carbaryl (10, 50 mg/kg) decreased theta area, and decreased delta and increased beta frequency. Triadimefon (75, 150 mg/kg) produced minimal changes in the EEG. The results show that the EEG is affected differently by approximately equipotent doses of pesticides with different modes of action. Published by Elsevier Inc.
C1 [Freeborn, Danielle L.; McDaniel, Katherine L.; Moser, Virginia C.; Herr, David W.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Neurotoxicol Branch,Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
RP Herr, DW (reprint author), US EPA, NHEERL TAD NB, 109 TW Alexander Dr,MD 8105-05, Res Triangle Pk, NC 27711 USA.
EM Freebom.danielle@epa.gov; McDaniel.kathy@epa.gov; Moser.ginger@epa.gov;
Herr.david@epa.gov
FU United States Environmental Protection Agency
FX We thank Drs. Tim Shafer and William Boyes for their helpful comments on
an earlier version of this manuscript. Appreciation is also expressed to
Mr. Charles Hamm for the computer assistance and Dr. Laura Degn with the
technical assistance with experimental procedures. All work was
internally funded by the United States Environmental Protection Agency.
NR 95
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Z9 2
U1 6
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 15
PY 2015
VL 282
IS 2
BP 184
EP 194
DI 10.1016/j.taap.2014.11.011
PG 11
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CA8UC
UT WOS:000349195400007
PM 25481984
ER
PT J
AU Vanderhoof, MK
Williams, CA
AF Vanderhoof, Melanie K.
Williams, Christopher A.
TI Persistence of MODIS evapotranspiration impacts from mountain pine
beetle outbreaks in lodgepole pine forests, south-central Rocky
Mountains
SO AGRICULTURAL AND FOREST METEOROLOGY
LA English
DT Article
DE Evapotranspiration; Water cycle; Bark beetles; Mountain pine beetles;
Disturbance; MODIS
ID SUB-ALPINE FOREST; ENERGY-EXCHANGE; WATER YIELD; STAND AGE; LEAF-AREA;
VEGETATION; ALGORITHM; COLORADO; CARBON; SCALE
AB The current extent and high severity (percent tree mortality) of mountain pine beetle outbreaks across western North America has been attributed to regional climate change, specifically warmer summer and winter temperatures and drier summers. This study paired multiple mountain pine beetle outbreak location datasets, both current and historical, with Moderate Resolution Imaging Spectroradiometer (MODIS) and Global Modeling and Assimilation Office (GMAO) Modern Era Retrospective-Analysis for Research and Applications (MERRA) products in order to quantify the full seasonal evapotranspiration impact of outbreak events for decades after outbreak (0 to 60 years). Following mountain pine beetle outbreaks in lodgepole pine (Pinus contorta) stands in the Colorado Rockies we observed an 18.7 +/- 1.4% (p < 0.01) reduction in the rate of summer evapotranspiration at 14 to 20 years since outbreak. We also observed a 21.6 +/- 2.2% (p < 0.01) increase in the rate of summer evapotranspiration, relative to non-attacked stands, in intermediate-aged stands 30 to 40 years since outbreak. Changes to growing season evapotranspiration correlated positively with changes in stand density, stand leaf area index (LAI) and the fraction of absorbed photosynthetically active radiation (fPAR), while high incoming solar radiation during the summer months acted to amplify changes to evapotranspiration even given relatively minor changes to summer WAR and LAI due to the rapid regeneration of understory vegetation. Lodgepole pine mortality from mountain pine beetle outbreaks showed lasting effects on stand-scale evapotranspiration which could have important implications for regional water resources. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Vanderhoof, Melanie K.; Williams, Christopher A.] Clark Univ, Grad Sch Geog, Worcester, MA 01610 USA.
RP Vanderhoof, MK (reprint author), US EPA, ORISE, Off Res & Dev, Natl Ctr Environm Assessment, 1200 Penn Ave,NW 8623-P, Washington, DC 20460 USA.
EM vanderhoof.melanie@epa.gov
FU NASA Headquarters under the NASA Earth and Space Science Fellowship
Program [12-Earth12R-59, 13-Earth13R-8]; Science of Terra and Aqua
program [NASA ROSES09, NNX11AG53G]; National Science Foundation
[1262691]
FX This work was supported by NASA Headquarters under the NASA Earth and
Space Science Fellowship Program (Grant no. 12-Earth12R-59 and
13-Earth13R-8). Additional financial support was received from the NASA
ROSES09 Science of Terra and Aqua program (Grant no. NNX11AG53G) as well
as the National Science Foundation (Grant no. 1262691). We thank Rocky
Mountain National Park for their field support and Marcus Pasay for his
assistance with field work. We also thank Dominik Kulakowski and Dan
Jarvis for providing the dendroecological plot data, Brian Howell and
Justin Backsen of the USFS Region 2, for their assistance with the
historical ADS surveys, and the anonymous reviewers for the valuable
comments.
NR 79
TC 4
Z9 4
U1 0
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1923
EI 1873-2240
J9 AGR FOREST METEOROL
JI Agric. For. Meteorol.
PD JAN 15
PY 2015
VL 200
BP 78
EP 91
DI 10.1016/j.agrformet.2014.09.015
PG 14
WC Agronomy; Forestry; Meteorology & Atmospheric Sciences
SC Agriculture; Forestry; Meteorology & Atmospheric Sciences
GA AY4ZB
UT WOS:000347582300008
ER
PT J
AU Simon, H
Reff, A
Wells, B
Xing, J
Frank, N
AF Simon, Heather
Reff, Adam
Wells, Benjamin
Xing, Jia
Frank, Neil
TI Ozone Trends Across the United States over a Period of Decreasing NOx
and VOC Emissions
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID GROUND-LEVEL OZONE; AIR
AB In this work, we evaluate ambient ozone trends at urban, suburban, and rural monitoring sites across the United States over a period of decreasing NOx and VOC emissions (1998-2013). We find that decreasing ozone trends generally occur in the summer, in less urbanized areas, and at the upper end of the ozone distribution. Conversely, increasing ozone trends generally occur in the winter, in more urbanized areas, and at the lower end of the ozone distribution. The 95(th) percentile ozone concentrations decreased at urban, suburban, and rural monitors by 1-2 ppb/yr in the summer and 0.5-1 ppb/yr in the winter. In the summer, there are both increasing and decreasing trends in fifth percentile ozone concentrations of less than 0.5 ppb/yr at urban and suburban monitors, while fifth percentile ozone concentrations at rural monitors decreased by up to 1 ppb/yr. In the winter, fifth percentile ozone concentrations generally increased by 0.1-1 ppb/yr. These results demonstrate the large scale success of U.S. control strategies targeted at decreasing peak ozone concentrations. In addition, they indicate that as anthropogenic NOx emissions have decreased, the ozone distribution has been compressed, leading to less spatial and temporal variability.
C1 [Simon, Heather; Reff, Adam; Wells, Benjamin; Frank, Neil] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Xing, Jia] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Simon, H (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM Simon.Heather@epa.gov
RI xing, jia/O-1784-2014; simon, heather/E-4392-2011
OI simon, heather/0000-0001-7254-3360
FU U.S. Department of Energy [DE-SC000378]; U.S. EPA [25 RW-89-9233260 1]
FX The authors would like to thank the following people from U.S. EPA for
their helpful feedback on this manuscript: James Hemby, Tyler Fox, Liz
Naess, Norm Possiel, Pat Dolwick, Bryan Hubbell, Scott Mathias, Mike
Koerber, Chet Wayland, Jan Cortelyou-Lee, and Chuen-Meei Gan. Although
this work has been reviewed and approved for publication by the U.S.
Environmental Protection Agency (EPA), it does not reflect the views and
policies of the agency. J.X. held a National Research Council Associate
award at U.S. EPA supported in part by an interagency agreement between
the U.S. Department of Energy project (IA no. DE-SC000378) and the U.S.
EPA (IA no. 25 RW-89-9233260 1).
NR 33
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Z9 33
U1 10
U2 49
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 6
PY 2015
VL 49
IS 1
BP 186
EP 195
DI 10.1021/es504514z
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AY5BW
UT WOS:000347589300021
PM 25517137
ER
PT J
AU Mazur, CS
Marchitti, SA
Zastre, J
AF Mazur, Christopher S.
Marchitti, Satori A.
Zastre, Jason
TI P-glycoprotein inhibition by the agricultural pesticide propiconazole
and its hydroxylated metabolites: Implications for pesticide-drug
interactions
SO TOXICOLOGY LETTERS
LA English
DT Article
DE P-gp; MDR1; Conazoles; Propiconazole; Chemosensitization; ABC
transporters
ID NONSTEROIDAL AROMATASE INHIBITORS; ORAL BIOAVAILABILITY; IN-VITRO;
CLINICAL IMPORTANCE; CACO-2 CELLS; TRANSPORTERS; ERYTHROMYCIN; EFFLUX;
KETOCONAZOLE; ANTIFUNGALS
AB The human efflux transporter P-glycoprotein (P-gp, MDR1) functions as an important cellular defense system against a variety of xenobiotics; however, little information exists on whether environmental chemicals interact with P-gp. Conazoles provide a unique challenge to exposure assessment because of their use as both pesticides and drugs. Propiconazole is an agricultural pesticide undergoing evaluation by the U. S. Environmental Protection Agency's Endocrine Disruptor Screening Program. In this study, the P-gp interaction of propiconazole and its hydroxylated metabolites were evaluated using MDR1expressing membrane vesicles and NIH-3T3/MDR1 cells. Membrane vesicle assays demonstrated propiconazole (IC50,122.9 mu M) and its metabolites (IC(50)s, 350.8 mu M, 366.4 mu M, and 456.3 mu M) inhibited P-gp efflux of a probe substrate, with propiconazole demonstrating the strongest interaction. P-gp mediated transport of propiconazole in MDR1-expressed vesicles was not detected indicating propiconazole interacts with P-gp as an inhibitor rather than a substrate. In NIH-3T3/MDR1 cells, propiconazole (1 and 10 mu M) led to decreased cellular resistance (chemosensitization) to paclitaxel, a chemotherapeutic drug and known MDR1 substrate. Collectively, these results have pharmacokinetic and risk assessment implications as P-gp interaction may influence pesticide toxicity and the potential for pesticide-drug interactions. Published by Elsevier Ireland Ltd.
C1 [Mazur, Christopher S.; Marchitti, Satori A.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
[Zastre, Jason] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA.
RP Mazur, CS (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM mazur.chris@epa.gov; marchitti.satori@epa.gov; jzastre@uga.edu
NR 36
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Z9 3
U1 3
U2 25
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD JAN 5
PY 2015
VL 232
IS 1
BP 37
EP 45
DI 10.1016/j.toxlet.2014.09.020
PG 9
WC Toxicology
SC Toxicology
GA AW3GT
UT WOS:000346175100005
PM 25268938
ER
PT J
AU Vance, L
Eason, T
Cabezas, H
AF Vance, Leisha
Eason, Tarsha
Cabezas, Heriberto
TI An information theory-based approach to assessing the sustainability and
stability of an island system
SO INTERNATIONAL JOURNAL OF SUSTAINABLE DEVELOPMENT AND WORLD ECOLOGY
LA English
DT Article
DE Fisher information; Puerto Rico; regional system; sustainability;
dynamic order; indicator
ID SAN-LUIS BASIN; REGIONAL SUSTAINABILITY; FISHER INFORMATION; REGIME
SHIFTS; PUERTO-RICO; CRITICAL TRANSITIONS; ECOLOGICAL-SYSTEMS; COLORADO;
COMMUNICATION; FRAMEWORK
AB It is well documented that a sustainable system is based on environmental stewardship, economic viability, and social equity. What is often overlooked is the need for continuity such that desirable system behavior is maintained with mechanisms in place that facilitate the ability of core system functions to endure or adapt (in the face of perturbations), and ensure that future generations are able to meet their needs. Assessing regional systems poses unique challenges in that they are interlinked with larger- and smaller-scale dynamics that may dramatically affect trends in key system variables. From 1970-2009, Puerto Rico experienced a 140% increase in urban population which may have amplified impacts related to resource demands, waste production, and natural habitats. Because such changes can have strong implications for sustainability, the dynamics of Puerto Rico provide a great opportunity to explore methods for assessing the sustainability of a complex geographic region. In this work, we employ Fisher information, an information theory-based approach, to evaluate changes in system dynamics and examine the effect of regionalization impacts on trends in variables characterizing social, environmental, and economic aspects of the system. Results indicate dramatic change from 1981-1999, after which the system dynamics remained steady until 2005. While there was no indication that a regime shift occurred, system trends corresponded with variations in non-yield economic variables. To determine whether Fisher information provides warning signals of critical change, consecutive declines in the index were explored and demonstrated as a possible leading indicator of impending regime shifts.
C1 [Vance, Leisha; Eason, Tarsha; Cabezas, Heriberto] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
RP Cabezas, H (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Cabezas.Heriberto@epa.gov
FU U.S. EPA
FX U.S. EPA.
NR 53
TC 2
Z9 2
U1 1
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1350-4509
EI 1745-2627
J9 INT J SUST DEV WORLD
JI Int. J. Sustain. Dev. World Ecol.
PD JAN 2
PY 2015
VL 22
IS 1
BP 64
EP 75
DI 10.1080/13504509.2014.978832
PG 12
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Ecology
SC Science & Technology - Other Topics; Environmental Sciences & Ecology
GA CA8GM
UT WOS:000349155800007
ER
PT J
AU Kariisa, M
Foraker, R
Pennell, M
Buckley, T
Diaz, P
Criner, GJ
Wilkins, JR
AF Kariisa, Mbabazi
Foraker, Randi
Pennell, Michael
Buckley, Timothy
Diaz, Philip
Criner, Gerard J.
Wilkins, J. R., III
TI Short- and Long-Term Effects of Ambient Ozone and Fine Particulate
Matter on the Respiratory Health of Chronic Obstructive Pulmonary
Disease Subjects
SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
LA English
DT Article
DE spirometry; COPD; air pollution; lung function
ID EMPHYSEMA TREATMENT TRIAL; VOLUME REDUCTION SURGERY; AIR-POLLUTION;
NATIONAL EMPHYSEMA; EXPOSURE; QUESTIONNAIRE; PATHOGENESIS
AB To date, no study has evaluated the short- and long-term effects air pollution exposure on emphysematous subjects who have undergone lung volume reduction surgery (LVRS). Data from the National Emphysema Treatment Trial study (1998-2003) included 1,218 subjects, aged 39 to 84. Daily values of ambient fine particulate matter (aerodynamic diameter < 2.5 mu m; PM2.5) and ozone were obtained. Mixed-effects models tested the association between short- and long-term pollutant concentrations and changes in pulmonary function. Cumulative air pollution exposure was strongly associated with worsened respiratory function and symptoms. Mean PM2.5 was associated with poorer lung function. Lagged exposures were poorly associated with respiratory health outcomes. There were detrimental respiratory and pulmonary effects observed in response to even low levels of ambient air pollutants among study participants. These results are indicative that exposures even below those of air quality standards may still pose significant risks to severe chronic obstructive pulmonary disease (COPD) subjects.
C1 [Kariisa, Mbabazi; Foraker, Randi; Wilkins, J. R., III] Ohio State Univ, Coll Publ Hlth, Div Epidemiol, Columbus, OH 43210 USA.
[Pennell, Michael] Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USA.
[Buckley, Timothy] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Diaz, Philip] Ohio State Univ, Wexner Med Ctr, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA.
[Criner, Gerard J.] Temple Univ, Sch Med, Ctr Inflammat Translat & Clin Lung Res, Dept Med,Sect Pulm & Crit Care Med, Philadelphia, PA 19122 USA.
RP Kariisa, M (reprint author), Ohio Dept Hlth, Violence & Injury Prevent Program, Bur Hlth Ohio, 246 North High St, Columbus, OH 43215 USA.
EM mbabazi.kariisa@odh.ohio.gov
NR 23
TC 5
Z9 5
U1 4
U2 43
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1933-8244
EI 2154-4700
J9 ARCH ENVIRON OCCUP H
JI Arch. Environ. Occup. Health
PD JAN 2
PY 2015
VL 70
IS 1
BP 56
EP 62
DI 10.1080/19338244.2014.932753
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AW3OP
UT WOS:000346196600008
PM 25136856
ER
PT J
AU Bostian, M
Sinha, A
Whittaker, G
Barnhart, B
AF Bostian, Moriah
Sinha, Ankur
Whittaker, Gerald
Barnhart, Bradley
GP IEEE
TI Incorporating Data Envelopment Analysis Solution Methods into Bilevel
Multi-Objective Optimization
SO 2015 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION (CEC)
SE IEEE Congress on Evolutionary Computation
LA English
DT Proceedings Paper
CT IEEE Congress on Evolutionary Computation (CEC)
CY MAY 25-28, 2015
CL Sendai, JAPAN
SP IEEE
DE Bilevel multi-objective optimization; Data envelopment analysis; Bilevel
evolutionary algorithm; Nitrogen pollution
ID EVOLUTIONARY ALGORITHMS; EFFICIENCY ANALYSIS; GENETIC ALGORITHM;
DECISION-MAKING; MANAGEMENT; SERVICES; MODELS; DEA
AB This study illustrates the use of Data Envelopment Analysis (DEA) solution methods in bilevel optimization problems. Here, we show that DEA and bilevel optimization can also be used together as part of an integrated solution framework. We work with a policy-oriented problem in which the regulator's multi-objective optimization problem at the upper level is constrained by the profit-maximizing decisions of individual firms at the lower level. Each firm's response to the policy is a prori unknown to the regulator, and depends on the underlying production technology. Rather than assuming a common production relationship across firms, DEA allows us to model each firm's response to the policy without imposing a functional form on the production technology. We use DEA to estimate the technology facing each producer, based on observed practices of other producers. Doing so endogenizes the cost of responding to prospective policies at the lower level, providing a more realistic solution set at the upper level. Our application addresses the design of a policy to reduce fertilizer runoff from agriculture, an important problem in environmental economics. We employ a multi-objective bilevel evolutionary algorithm to solve for the approximate optimal frontier.
C1 [Bostian, Moriah] Lewis & Clark Coll, Dept Econ, Portland, OR 97219 USA.
[Sinha, Ankur] Indian Inst Management, Prod & Quantitat Methods, Ahmadabad 380015, Gujarat, India.
[Whittaker, Gerald] USDA ARS, Corvallis, OR 97331 USA.
[Barnhart, Bradley] US EPA, Corvallis, OR 97331 USA.
RP Bostian, M (reprint author), Lewis & Clark Coll, Dept Econ, Portland, OR 97219 USA.
EM mbbostian@lclark.edu; asinha@iimahd.ernet.in; whittakg@onid.orst.edu;
bradleybarnhart@gmail.com
NR 38
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4799-7492-4
J9 IEEE C EVOL COMPUTAT
PY 2015
BP 1667
EP 1674
PG 8
WC Computer Science, Artificial Intelligence
SC Computer Science
GA BF1YE
UT WOS:000380444801092
ER
PT B
AU Jerrett, M
Reid, CE
McKone, TE
Koutrakis, P
AF Jerrett, Michael
Reid, Colleen E.
McKone, Thomas E.
Koutrakis, Petros
BE Kanaroglou, P
Delmelle, E
Paez, A
TI Participatory and Ubiquitous Sensing for Exposure Assessment in Spatial
Epidemiology
SO SPATIAL ANALYSIS IN HEALTH GEOGRAPHY
SE Geographies of Health
LA English
DT Article; Book Chapter
ID FINE PARTICULATE MATTER; AIR-POLLUTION EXPOSURE; LONG-TERM EXPOSURE;
AEROSOL OPTICAL DEPTH; LAND-USE REGRESSION; PHYSICAL-ACTIVITY;
INFORMATION-SYSTEM; COMMUNITY DESIGN; PARTICLE MONITOR; SATELLITE
C1 [Jerrett, Michael] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90024 USA.
[Jerrett, Michael; McKone, Thomas E.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Reid, Colleen E.] Univ Calif Berkeley, Sch Publ Hlth, Environm Hlth Sci, Berkeley, CA 94720 USA.
[Reid, Colleen E.] US EPA, Global Change Res Program, Washington, DC 20460 USA.
[McKone, Thomas E.] Lawrence Berkeley Natl Lab, Berkeley, CA USA.
[McKone, Thomas E.] US EPA, Sci Advisory Board, Washington, DC 20460 USA.
[McKone, Thomas E.] World Hlth Org, Geneva, Switzerland.
[McKone, Thomas E.] Soc Risk Anal, Mclean, VA USA.
[McKone, Thomas E.] Int Soc Exposure Sci, Herndon, VA USA.
[Koutrakis, Petros] EPA Harvard Univ, Clean Air Res Ctr, Cambridge, MA USA.
[Koutrakis, Petros] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA.
RP Jerrett, M (reprint author), Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90024 USA.
NR 91
TC 0
Z9 0
U1 0
U2 0
PU ASHGATE PUBLISHING LTD
PI ALDERSHOT
PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND
BN 978-1-47-241620-9; 978-1-47-241619-3
J9 GEOGR HEALTH
PY 2015
BP 219
EP 239
PG 21
WC Geography; Public, Environmental & Occupational Health
SC Geography; Public, Environmental & Occupational Health
GA BG0RI
UT WOS:000386481100013
ER
PT B
AU Andrew, JT
AF Andrew, John T.
BA Lassiter, A
BF Lassiter, A
TI Adapting California's Water Sector to a Changing Climate
SO SUSTAINABLE WATER: CHALLENGES AND SOLUTIONS FROM CALIFORNIA
LA English
DT Article; Book Chapter
C1 [Andrew, John T.] Calif Dept Water Resources, Climate Change Act, Sacramento, CA 95814 USA.
[Andrew, John T.] Stege Sanit Dist, El Cerrito, CA USA.
[Andrew, John T.] CALFED Bay Delta Program, Sacramento, CA USA.
[Andrew, John T.] Calif Dept Hlth Serv, Sacramento, CA 95814 USA.
[Andrew, John T.] Lawrence Berkeley Natl Lab, Berkeley, CA USA.
[Andrew, John T.] US Environm Protect Agcy, Washington, DC USA.
RP Andrew, JT (reprint author), Calif Dept Water Resources, Climate Change Act, Sacramento, CA 95814 USA.
NR 26
TC 0
Z9 0
U1 0
U2 0
PU UNIV CALIFORNIA PRESS
PI OAKLAND
PA 155 GRAND AVE, SUITE 400, OAKLAND, CA 94612-3758 USA
BN 978-0-520-28535-4; 978-0-520-96087-9; 978-0-520-28536-1
PY 2015
BP 10
EP 31
PG 22
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Studies; Water
Resources
SC Science & Technology - Other Topics; Environmental Sciences & Ecology;
Water Resources
GA BG0JU
UT WOS:000386291200002
ER
PT S
AU Steeger, T
Baris, R
Moriarty, T
Hart, C
Hou, W
AF Steeger, Thomas
Baris, Reuben
Moriarty, Thomas
Hart, Connie
Hou, Wayne
BE Oomen, PA
Pistorius, J
TI Assessing risks of pesticides to bees: putting the science into context
to inform regulatory decision making
SO HAZARDS OF PESTICIDES TO BEES: 12TH INTERNATIONAL SYMPOSIUM OF THE
ICP-PR BEE PROTECTION GROUP
SE Julius-Kuhn-Archiv
LA English
DT Proceedings Paper
CT 12th International Symposium of the ICP-PR Bee Protection Group -
Hazards of Pesticides to Bees
CY SEP 15-17, 2014
CL Ghent Univ, Fac Bioscience Engn, Ghent, BELGIUM
SP Int Commiss Plant Protect Relat
HO Ghent Univ, Fac Bioscience Engn
ID DECLINES; EUROPE
C1 [Steeger, Thomas; Baris, Reuben; Moriarty, Thomas] US EPA, Off Pesticide Programs, Washington, DC 20460 USA.
[Hart, Connie; Hou, Wayne] Hlth Canada, Pest Management Regulatory Agcy, Environm Assessment Directorate, Ottawa, ON, Canada.
RP Steeger, T (reprint author), US EPA, Off Pesticide Programs, Washington, DC 20460 USA.
NR 20
TC 0
Z9 0
U1 2
U2 2
PU JULIUS KUHN-INST
PI BERLIN
PA BUNDESFORSCHUNGSINSTITUT FUR KULTURPFLANZEN, KONIGN-LUISE-STRABE 19,
BERLIN, D-14195, GERMANY
SN 1868-9892
BN 978-3-95547-022-7
J9 JULIUS-KUHN-ARCH
JI Julius-Kuhn-Arch.
PY 2015
VL 450
BP 8
EP 16
PG 9
WC Entomology; Toxicology
SC Entomology; Toxicology
GA BF4YW
UT WOS:000381782400001
ER
PT S
AU Bakker, F
Christl, H
Coulson, M
Dinter, A
Giffard, H
Hanewald, N
Lewis, G
Miles, M
Pistorius, J
van Praagh, J
Randall, M
Vergnet, C
Hart, C
Sandrock, C
Steeger, T
AF Bakker, Frank
Christl, Heino
Coulson, Mike
Dinter, Axel
Giffard, Herve
Hanewald, Nicole
Lewis, Gavin
Miles, Mark
Pistorius, Jens
van Praagh, Job
Randall, Marit
Vergnet, Christine
Hart, Connie
Sandrock, Christoph
Steeger, Thomas
BE Oomen, PA
Pistorius, J
TI Semi-field and field testing on the honey bee working group
SO HAZARDS OF PESTICIDES TO BEES: 12TH INTERNATIONAL SYMPOSIUM OF THE
ICP-PR BEE PROTECTION GROUP
SE Julius-Kuhn-Archiv
LA English
DT Proceedings Paper
CT 12th International Symposium of the ICP-PR Bee Protection Group -
Hazards of Pesticides to Bees
CY SEP 15-17, 2014
CL Ghent Univ, Fac Bioscience Engn, Ghent, BELGIUM
SP Int Commiss Plant Protect Relat
HO Ghent Univ, Fac Bioscience Engn
C1 [Bakker, Frank] Eurofins, Amsterdam, Netherlands.
[Christl, Heino] Tier, Leichlingen, Germany.
[Coulson, Mike] Syngenta, Basel, Switzerland.
[Dinter, Axel] DuPont Co Inc, Wilmington, DE USA.
[Giffard, Herve] Testapi, Gennes, France.
[Hanewald, Nicole] BASF, Ludwigshafen, Germany.
[Lewis, Gavin] JSC, Harrogate, N Yorkshire, England.
[Miles, Mark] BCS, New Orleans, LA USA.
[Pistorius, Jens] JKI, Quedlinburg, Germany.
[van Praagh, Job] ICPPR, Guelph, ON, Canada.
[Randall, Marit] Norwegian FSA, Oslo, Norway.
[Vergnet, Christine] ANSES, Maisons Alfort, France.
[Hart, Connie] Hlth Canada, Ottawa, ON, Canada.
[Sandrock, Christoph] IES, Witterswil, Switzerland.
[Steeger, Thomas] US EPA, Washington, DC 20460 USA.
RP Bakker, F (reprint author), Eurofins, Amsterdam, Netherlands.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU JULIUS KUHN-INST
PI BERLIN
PA BUNDESFORSCHUNGSINSTITUT FUR KULTURPFLANZEN, KONIGN-LUISE-STRABE 19,
BERLIN, D-14195, GERMANY
SN 1868-9892
BN 978-3-95547-022-7
J9 JULIUS-KUHN-ARCH
JI Julius-Kuhn-Arch.
PY 2015
VL 450
BP 152
EP 153
PG 2
WC Entomology; Toxicology
SC Entomology; Toxicology
GA BF4YW
UT WOS:000381782400025
ER
PT S
AU Humayun, M
Divan, R
Stan, L
Rosenmann, D
Gosztola, D
Gundel, L
Solomon, PA
Paprotny, I
AF Humayun, Md
Divan, R.
Stan, L.
Rosenmann, D.
Gosztola, D.
Gundel, L.
Solomon, P. A.
Paprotny, I.
GP IEEE
TI Functionalized Multi-Walled Carbon Nanotube based Sensors for
Distributed Methane Leak Detection
SO 2015 IEEE SENSORS
SE IEEE Sensors
LA English
DT Proceedings Paper
CT 2015 IEEE SENSORS
CY NOV 01-04, 2015
CL Busan, SOUTH KOREA
SP IEEE, Sensors Council, Korean Sensors Soc
AB This paper presents a highly sensitive, energy efficient and low-cost distributed methane (CH4) sensor system (DMSS) for continuous monitoring, detection and localization of CH4 leaks in natural gas infrastructure such as transmission and distribution pipelines, wells, and production pads. The CH4 sensing element, a key component of the DMSS, consists of a metal oxide functionalized multi-walled carbon nanotube (MWCNT) mesh which, in comparison to existing literature, shows stronger relative resistance change while interacting with lower ppm concentreation of CH4. For the DMSS a Gaussian plume triangulation algorithm has been developed, which, given a geometric model of the surrounding environment, can precisely detect and localize a CH4 leak as well as estimate its mass flow rate.
C1 [Humayun, Md; Paprotny, I.] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
[Divan, R.; Stan, L.; Rosenmann, D.; Gosztola, D.] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA.
[Gundel, L.] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
[Solomon, P. A.] US EPA, Las Vegas, NV 89199 USA.
RP Humayun, M (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
EM paprotny@uic.edu
NR 7
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1930-0395
BN 978-1-4799-8203-5
J9 IEEE SENSOR
PY 2015
BP 177
EP 180
PG 4
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA BF1WO
UT WOS:000380440800046
ER
PT S
AU Mahdavipour, O
Mueller-Sim, T
Fahimi, D
Croshere, S
Pillatsch, P
Merukh, J
Baruffa, VZ
Sabino, J
Tran, K
Alanis, G
Solomon, P
Wright, P
White, RM
Gundel, L
Paprotny, I
AF Mahdavipour, Omid
Mueller-Sim, Timothy
Fahimi, Dorsa
Croshere, Skot
Pillatsch, Pit
Merukh, Jusuf
Baruffa, Valentino Zegna
Sabino, John
Tran, Koji
Alanis, Giovanni
Solomon, Paul
Wright, Paul
White, Richard M.
Gundel, Lara
Paprotny, Igor
GP IEEE
TI Wireless Sensors for Automated Control of Total Incombustible Content
(TIC) of Dust Deposited in Underground Coal Mines
SO 2015 IEEE SENSORS
SE IEEE Sensors
LA English
DT Proceedings Paper
CT 2015 IEEE SENSORS
CY NOV 01-04, 2015
CL Busan, SOUTH KOREA
SP IEEE, Sensors Council, Korean Sensors Soc
DE Float Dust; Wireless Sensor Networks; Total Incombustible Content
AB This paper presents ongoing research towards a low-cost/low-power wirelessly enabled distributed sensing system that can be placed throughout underground coal mines to potentially measure the total incombustible content (TIC) of the deposited dust. Underground coal mining operations produce finely divided coal dust, called float dust, which deposits throughout the mine. This combustible material can be feedstock for coal dust explosions. In the U.S., Mine Safety and Health Administration (MSHA) standard 23789 dictates that a TIC of 80% or above has to be maintained in coal mine return airways. However, current best practices for collection TIC measurements involve manual sampling and laboratory procedures. In this work, we describe work towards developing a new wireless sensor network (WSN) consisting of low-cost/low-power sensor modules that use a variety of optical and microfabricated sensors to continuously monitor the TIC of the accumulated dust. The information is then transmitted off-board through a reliable ad-hoc wireless network. Called Sensors for Automated Control of Coal Dust (SACCD), this system can potentially, for example, be used to automate the control of rock-dusting equipment to maintain TIC at acceptable levels.
C1 [Mahdavipour, Omid; Mueller-Sim, Timothy; Fahimi, Dorsa; Baruffa, Valentino Zegna; Sabino, John; Tran, Koji; Alanis, Giovanni; Paprotny, Igor] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
[Croshere, Skot; Pillatsch, Pit; Merukh, Jusuf; Wright, Paul; White, Richard M.] Univ Calif, Berkeley, CA USA.
[Solomon, Paul] US EPA, Las Vegas, NV 89193 USA.
[Gundel, Lara] Lawrence Berkeley Natl Lab, Berkeley, CA USA.
RP Mahdavipour, O (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
EM paprotny@uic.edu
NR 6
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1930-0395
BN 978-1-4799-8203-5
J9 IEEE SENSOR
PY 2015
BP 703
EP 706
PG 4
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA BF1WO
UT WOS:000380440800187
ER
PT J
AU Bolt, MD
AF Bolt, M. D.
BE Yang, C
Clarke, K
Yuan, M
Yu, M
Li, M
Guan, W
Sun, M
Huang, B
TI Visualizing Water Quality Sampling-Events in Florida
SO ISPRS International Workshop on Spatiotemporal Computing
LA English
DT Proceedings Paper
CT ISPRS International Workshop on Spatiotemporal Computing
CY JUL 13-15, 2015
CL Fairfax, VA
DE Water Quality; Visualization; Florida; R; GIS; Spatiotemporal;
Communication
AB Water quality sampling in Florida is acknowledged to be spatially and temporally variable. The rotational monitoring program that was created to capture data within the state's thousands of miles of coastline and streams, and millions of acres of lakes, reservoirs, and ponds may be partly responsible for inducing the variability as an artifact. Florida's new dissolved-oxygen-standard methodology will require more data to calculate a percent saturation. This additional data requirement's impact can be seen when the new methodology is applied retrospectively to the historical collection. To understand how, where, and when the methodological change could alter the environmental quality narrative of state waters requires addressing induced bias from prior sampling events and behaviors. Here stream and coastal water quality data is explored through several modalities to maximize understanding and communication of the spatiotemporal relationships. Previous methodology and expected-retrospective calculations outside the regulatory framework are found to be significantly different, but dependent on the spatiotemporal perspective. Data visualization is leveraged to demonstrate these differences, their potential impacts on environmental narratives, and to direct further review and analysis.
C1 [Bolt, M. D.] US EPA, Oak Ridge Inst Sci & Educ, Sam Nunn Atlanta Fed Ctr, 61 Forsyth St SW, Atlanta, GA 30303 USA.
RP Bolt, MD (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Sam Nunn Atlanta Fed Ctr, 61 Forsyth St SW, Atlanta, GA 30303 USA.
EM bolt.matthew@epa.gov
NR 8
TC 0
Z9 0
U1 0
U2 0
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLE 1E, GOTTINGEN, 37081, GERMANY
PY 2015
BP 73
EP 78
DI 10.5194/isprsannals-II-4-W2-73-2015
PG 6
WC Computer Science, Interdisciplinary Applications; Geography, Physical;
Remote Sensing; Imaging Science & Photographic Technology
SC Computer Science; Physical Geography; Remote Sensing; Imaging Science &
Photographic Technology
GA BF3IZ
UT WOS:000380547600031
ER
PT J
AU Arunachalam, S
Brantley, H
Barzyk, TM
Hagler, G
Isakov, V
Kimbrough, ES
Naess, B
Rice, N
Snyder, MG
Talgo, K
Venkatram, A
AF Arunachalam, Saravanan
Brantley, Halley
Barzyk, Timothy M.
Hagler, Gayle
Isakov, Vlad
Kimbrough, Evelyn S.
Naess, Brian
Rice, Nathan
Snyder, Michelle G.
Talgo, Kevin
Venkatram, Akula
TI Assessment of port-related air quality impacts: geographic analysis of
population
SO INTERNATIONAL JOURNAL OF ENVIRONMENT AND POLLUTION
LA English
DT Article
DE port; emissions; air quality; dispersion; GIS; cargo; freight; trucks;
near source; near port; population exposure
ID HEALTH
AB Increased global trade has led to greater transportation by rail, road and ships to move cargo. Based upon multiple near-road and near-source monitoring studies, the busy roadways and large emission sources at ports may impact local air quality within several hundred metres of the ports. Health effects have been associated with near-road exposures and proximity to large emission sources, so characterising emission sources is important for understanding potential health effects. To address this need, we have developed a new community-scale tool called C-PORT to model emissions related to all port-area activities and predict concentrations of multiple criteria and hazardous air pollutants at fine spatial scales in the near-source environment. We present a geographical information system analysis of areas surrounding five US ports (Ports of New York and New Jersey, Virginia, Savannah, Miami, and Houston) to determine potential sources of concern related to freight transport and demographics of the near-source population that could be affected.
C1 [Arunachalam, Saravanan; Naess, Brian; Snyder, Michelle G.; Talgo, Kevin] Univ North Carolina Chapel Hill, Inst Environm, Campus Box 1105 27599-1105,100 Europa Dr, Chapel Hill, NC 27517 USA.
[Brantley, Halley; Kimbrough, Evelyn S.] US EPA, Air Pollut Prevent & Characterizat Div, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Barzyk, Timothy M.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[Hagler, Gayle] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Isakov, Vlad] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Rice, Nathan] Univ North Carolina Chapel Hill, Informat Technol Serv Res Comp, Chapel Hill, NC 27599 USA.
[Venkatram, Akula] Univ Calif Riverside, Bourns Coll Engn, Riverside, CA 92521 USA.
RP Arunachalam, S (reprint author), Univ North Carolina Chapel Hill, Inst Environm, Campus Box 1105 27599-1105,100 Europa Dr, Chapel Hill, NC 27517 USA.
EM sarav@email.unc.edu; brantley.halley@epa.gov; Barzyk.Timothy@epa.gov;
Hagler.Gayle@epa.gov; Isakov.Vlad@epa.gov; Kimbrough.Sue@epa.gov;
naess@unc.edu; Nathan_rice@unc.edu; mgs3584@email.unc.edu;
talgo@email.unc.edu; venky@engr.ucr.edu
OI Kimbrough, Evelyn Sue/0000-0002-7246-0255
NR 27
TC 0
Z9 0
U1 1
U2 4
PU INDERSCIENCE ENTERPRISES LTD
PI GENEVA
PA WORLD TRADE CENTER BLDG, 29 ROUTE DE PRE-BOIS, CASE POSTALE 856, CH-1215
GENEVA, SWITZERLAND
SN 0957-4352
EI 1741-5101
J9 INT J ENVIRON POLLUT
JI Int. J. Environ. Pollut.
PY 2015
VL 58
IS 4
SI SI
BP 231
EP 250
DI 10.1504/IJEP.2015.077455
PN 3
PG 20
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DQ5AL
UT WOS:000379216700002
ER
PT B
AU Shadbegian, RJ
Wolverton, A
AF Shadbegian, Ronald J.
Wolverton, Ann
BE Konisky, DM
TI Evaluating Environmental Justice: Analytic Lessons from the Academic
Literature and in Practice
SO FAILED PROMISES: EVALUATING THE FEDERAL GOVERNMENT'S RESPONSE TO
ENVIRONMENTAL JUSTICE
SE American and Comparative Environmental Policy
LA English
DT Article; Book Chapter
ID SOUTHERN CALIFORNIA; TOXIC RELEASES; AIR TOXICS; EQUITY; RISK;
DEMOGRAPHICS; INEQUITIES; ENFORCEMENT; PERFORMANCE; DISPARITIES
C1 [Shadbegian, Ronald J.] US EPA, NCEE, Washington, DC 20460 USA.
RP Shadbegian, RJ (reprint author), US EPA, NCEE, Washington, DC 20460 USA.
EM Shadbegian.ron@epa.gov; Wolverton.ann@epa.gov
NR 59
TC 1
Z9 1
U1 1
U2 1
PU MIT PRESS
PI CAMBRIDGE
PA FIVE CAMBRIDGE CENTER, CAMBRIDGE, MA 02142 USA
BN 978-0-262-52735-4; 978-0-262-02883-7
J9 AM COMP ENVIRON POLI
PY 2015
BP 117
EP 142
D2 10.7551/mitpress/9780262028837.001.0001
PG 26
WC Environmental Studies; Political Science; Social Sciences,
Interdisciplinary
SC Environmental Sciences & Ecology; Government & Law; Social Sciences -
Other Topics
GA BE8GM
UT WOS:000376451800007
ER
PT J
AU Ghio, A
Soukup, J
Dailey, L
Kesic, MJ
Cohen, MD
AF Ghio, A.
Soukup, J.
Dailey, L.
Kesic, M. J.
Cohen, M. D.
TI Iron Diminishes The In Vitro Biological Effect Of Vanadium
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Ghio, A.; Soukup, J.; Dailey, L.] US EPA, Chapel Hill, NC USA.
[Kesic, M. J.] Univ N Carolina, Chapel Hill, NC USA.
[Cohen, M. D.] NYU, Tuxedo Pk, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A3214
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582803489
ER
PT J
AU Kim, CS
Kehrl, H
Hazucha, M
Rappold, A
Devlin, RB
Diaz-Sanchez, D
AF Kim, C. S.
Kehrl, H.
Hazucha, M.
Rappold, A.
Devlin, R. B.
Diaz-Sanchez, D.
TI Variability Of Pulmonary Function Response To 6.6 Hour Exposure To Low
Concentration Ozone During Moderate Exercise
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Kim, C. S.; Kehrl, H.; Rappold, A.; Devlin, R. B.; Diaz-Sanchez, D.] US EPA, Res Triangle Pk, NC USA.
[Hazucha, M.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A5242
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582807062
ER
PT J
AU Soukup, JM
Dailey, L
Kesic, MJ
Tong, H
Ghio, A
AF Soukup, J. M.
Dailey, L.
Kesic, M. J.
Tong, H.
Ghio, A.
TI Wood Smoke Particles Sequester Mitochondrial Iron To Impact A Biological
Effect
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Soukup, J. M.; Dailey, L.; Tong, H.; Ghio, A.] US EPA, Chapel Hill, NC USA.
[Kesic, M. J.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A4034
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582805093
ER
PT J
AU Yu, Y
Hotten, D
Birukova, A
Volker, E
Ghio, AJ
Noble, PW
Kraft, M
Hollingsworth, JW
Gunn, MD
Tighe, RM
AF Yu, Y.
Hotten, D.
Birukova, A.
Volker, E.
Ghio, A. J.
Noble, P. W.
Kraft, M.
Hollingsworth, J. W.
Gunn, M. D.
Tighe, R. M.
TI Flow Cytometry Of Human Bronchoalveolar Lavage Fluid And Lung Tissue
Identifies Interstitial Macrophages
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
CT International Conference of the American-Thoracic-Society (ATS)
CY MAY 15-20, 2015
CL Denver, CO
SP Amer Thorac Soc
C1 [Yu, Y.; Hotten, D.; Birukova, A.; Volker, E.; Kraft, M.; Gunn, M. D.; Tighe, R. M.] Duke Univ, Med Ctr, Durham, NC USA.
[Ghio, A. J.] US EPA, Chapel Hill, NC USA.
[Noble, P. W.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Hollingsworth, J. W.] Ohio State Univ, Columbus, OH 43210 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PY 2015
VL 191
MA A1301
PG 1
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DO2AW
UT WOS:000377582800300
ER
PT S
AU Briskin, JS
Yohannes, L
AF Briskin, J. S.
Yohannes, L.
BE Drogos, DL
TI Overview of US EPA's Study of the Potential Impacts of Hydraulic
Fracturing for Oil and Gas on Drinking Water Resources
SO HYDRAULIC FRACTURING: ENVIRONMENTAL ISSUES
SE ACS Symposium Series
LA English
DT Article; Book Chapter
ID ENVIRONMENTAL-SAMPLES
C1 [Briskin, J. S.; Yohannes, L.] US EPA, Off Sci Policy, Off Res & Dev, 1200 Penn Ave NW,Mail Code 8104R, Washington, DC 20460 USA.
RP Briskin, JS (reprint author), US EPA, Off Sci Policy, Off Res & Dev, 1200 Penn Ave NW,Mail Code 8104R, Washington, DC 20460 USA.
EM Briskin.jeanne@epa.gov
NR 19
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3122-1
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1216
BP 197
EP 203
D2 10.1021/bk-2015-1216
PG 7
WC Engineering, Petroleum; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA BE5KI
UT WOS:000372944300009
ER
PT B
AU Xi, W
Ottinger, RL
Robinson, NA
Butzel, AK
Wieder, ME
Parker, JL
Rucinski, TL
Valova, RR
Wang, PP
AF Xi, Wang
Ottinger, Richard L.
Robinson, Nicholas A.
Butzel, Albert K.
Wieder, Marla E.
Parker, John Louis
Rucinski, Taryn L.
Valova, Radina R.
Wang Pianpian
BE Martin, P
Kennedy, A
TI Assessing environmental governance of the Hudson River Valley:
application of an IPPEP model
SO IMPLEMENTING ENVIRONMENTAL LAW
SE IUCN Academy of Environmental Law Series
LA English
DT Article; Book Chapter
C1 [Xi, Wang] Shanghai Jiao Tong Univ, Nat Resources Law Inst, Shanghai 200030, Peoples R China.
[Ottinger, Richard L.] IUCN World Commiss Environm Law, Energy & Climate Comm, London, England.
[Robinson, Nicholas A.] Pace Univ, Environm, New York, NY USA.
[Robinson, Nicholas A.] Pace Univ, Environm Law, New York, NY USA.
[Robinson, Nicholas A.] IUCN, New York, NY USA.
[Butzel, Albert K.] Albert K Butzel Law Off, New York, NY USA.
[Wieder, Marla E.] US EPA, Washington, DC USA.
[Parker, John Louis] NY Dept Environm Conservat, Washington, DC USA.
[Rucinski, Taryn L.] Pace Univ, Sch Law, Law, New York, NY USA.
RP Xi, W (reprint author), Shanghai Jiao Tong Univ, Nat Resources Law Inst, Shanghai 200030, Peoples R China.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU EDWARD ELGAR PUBLISHING LTD
PI CHELTENHAM
PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND
BN 978-1-78347-931-3; 978-1-78347-929-0
J9 IUCN ACAD ENVIR LAW
PY 2015
BP 50
EP 68
D2 10.4337/9781783479313
PG 19
WC Environmental Studies; Law
SC Environmental Sciences & Ecology; Government & Law
GA BE5DZ
UT WOS:000372628400003
ER
PT J
AU Ridley, CE
Mallory-Smith, C
AF Ridley, Caroline E.
Mallory-Smith, Carol
BE Quinn, LD
Matlaga, DP
Barney, JN
TI Gene Flow and Invasiveness in Bioenergy Systems
SO BIOENERGY AND BIOLOGICAL INVASIONS: ECOLOGICAL, AGRONOMIC, AND POLICY
PERSPECTIVES ON MINIMIZING RISK
SE CABI Invasives Series
LA English
DT Article; Book Chapter
ID JATROPHA-CURCAS L.; CANOLA BRASSICA-NAPUS; CALIFORNIA WILD RADISH;
PANICUM-VIRGATUM L.; GM OILSEED RAPE; CAMELINA-SATIVA; WIND-POLLINATION;
TRANSGENIC CROPS; RISK-ASSESSMENT; WESTERN CANADA
AB Gene flow between crops and their wild or weedy relatives can result in the establishment of hybrid populations outside of cultivation. Here, we examine the potential for gene flow between several emerging bioenergy feedstocks and their compatible relatives, and the factors that affect the magnitude and frequency of gene exchange. We also explore the potential that gene flow could lead to the escape of transgenes or invasion by resulting populations. A limited amount of information suggests that the potential for gene flow and invasion are low for jatropha (Jatropha curcas L.) and relatively greater for switchgrass (Panicum virgatum L.) where these crops are currently being cultivated. Camelina (Camelina sativa (L.) Crantz.) likely falls somewhere in between these two species. Canola (Brassica napus L. and Brassica rapa L.), a widely-grown crop already being used as a source of bioenergy, is a well-studied system in which weedy populations with crop ancestry have been found and transgenes have been detected outside of cultivation. From this case study, we suggest that both a Best Management Plan should be developed to limit gene flow between emerging bioenergy feedstocks and wild or weedy relatives, and a Mitigation Plan should be in place to address unintended release of transgenes and appearance of potentially invasive populations.
C1 [Ridley, Caroline E.] US EPA, 1200 Penn Ave NW,William Jefferson Clinton Bldg, Washington, DC 20460 USA.
[Mallory-Smith, Carol] Oregon State Univ, Dept Crop & Soil Sci, Corvallis, OR 97331 USA.
RP Ridley, CE (reprint author), US EPA, 1200 Penn Ave NW,William Jefferson Clinton Bldg, Washington, DC 20460 USA.
EM ridley.caroline@epa.gov; carol.mallory-smith@oregonstate.edu
NR 74
TC 0
Z9 0
U1 2
U2 9
PU CABI PUBLISHING-C A B INT
PI WALLINGFORD
PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND
BN 978-1-78064-330-4
J9 CABI INVASIVE SER
PY 2015
VL 5
BP 52
EP 66
D2 10.1079/9781780643304.0000
PG 15
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA BE6SD
UT WOS:000374698700004
ER
PT J
AU Tirado, MC
Amadeo, A
Chena, K
Mascarenas, A
AF Tirado, M. C.
Amadeo, A.
Chena, K.
Mascarenas, A.
TI Climate smart nutrition: Co-benefits of nutrition-sensitive climate
mitigation and adaptation
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Meeting Abstract
C1 [Tirado, M. C.; Amadeo, A.; Chena, K.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
[Tirado, M. C.] Int Union Nutr Sci Task Force Climate & Nutr, Washington, DC USA.
[Mascarenas, A.] US EPA, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2015
VL 67
SU 1
BP 19
EP 20
PG 2
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DK5VM
UT WOS:000374988800030
ER
PT S
AU Hollingsworth, JW
Nadadur, SS
AF Hollingsworth, John W.
Nadadur, Srikanth S.
BE Nadadur, SS
Hollingsworth, JW
TI Air Pollution and Health Effects Preface
SO AIR POLLUTION AND HEALTH EFFECTS
SE Molecular and Integrative Toxicology
LA English
DT Editorial Material; Book Chapter
ID AMERICAN-HEART-ASSOCIATION; CARDIOVASCULAR-DISEASE; STATEMENT
C1 [Hollingsworth, John W.] Ohio State Univ, Dept Internal Med, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA.
[Nadadur, Srikanth S.] Natl Inst Environm Hlth Sci, Div Extramural Res & Training, Res Triangle Pk, NC USA.
RP Hollingsworth, JW (reprint author), Ohio State Univ, Dept Internal Med, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA.
NR 5
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-1-4471-6669-6; 978-1-4471-6668-9
J9 MOLEC INTEGR TOXICOL
PY 2015
BP V
EP VII
D2 10.1007/978-1-4471-6669-6
PG 3
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE5XX
UT WOS:000373624200001
ER
PT S
AU Mudipalli, A
AF Mudipalli, Anuradha
BE Nadadur, SS
Hollingsworth, JW
TI Airborne Carcinogens: Mechanisms of Cancer
SO AIR POLLUTION AND HEALTH EFFECTS
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
ID POLYCYCLIC AROMATIC-HYDROCARBONS; ENVIRONMENTAL TOBACCO-SMOKE;
UNSCHEDULED DNA-SYNTHESIS; BENZENE-EXPOSED WORKERS; EXPERIMENTAL
MULTIPOTENTIAL CARCINOGEN; ALCOHOL-DEHYDROGENASE 3; STRAND BREAK REPAIR;
PROTEIN CROSS-LINKS; LUNG-CANCER; OCCUPATIONAL-EXPOSURE
C1 [Mudipalli, Anuradha] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Mudipalli, A (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Mudipalli.anu@epa.gov
NR 216
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-1-4471-6669-6; 978-1-4471-6668-9
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 151
EP 184
DI 10.1007/978-1-4471-6669-6_6
D2 10.1007/978-1-4471-6669-6
PG 34
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE5XX
UT WOS:000373624200007
ER
PT S
AU Sacks, JD
Fann, N
Owens, EO
Costa, DL
AF Sacks, Jason D.
Fann, Neal
Owens, Elizabeth Oesterling
Costa, Daniel L.
BE Nadadur, SS
Hollingsworth, JW
TI Using Science to Shape Policy
SO AIR POLLUTION AND HEALTH EFFECTS
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
ID PARTICULATE AIR-POLLUTION; UNITED-STATES; CHEMICAL-COMPOSITION; LIFE
EXPECTANCY; GLOBAL BURDEN; HEALTH BURDEN; MATTER; MORTALITY; OZONE;
ASSOCIATION
C1 [Sacks, Jason D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
[Owens, Elizabeth Oesterling] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Cincinnati, OH 45268 USA.
[Fann, Neal] US EPA, Off Air Qual Planning & Stand, Off Air & Radiat, Res Triangle Pk, NC 27711 USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Sacks, JD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM sacks.jason@epa.gov; fann.neal@epa.gov; owens.beth@epa.gov;
costa.dan@epa.gov
NR 47
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-1-4471-6669-6; 978-1-4471-6668-9
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 403
EP 436
DI 10.1007/978-1-4471-6669-6_15
D2 10.1007/978-1-4471-6669-6
PG 34
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE5XX
UT WOS:000373624200016
ER
PT S
AU Dewan, N
Majestic, BJ
Ketterer, ME
Miller-Schulze, JP
Shafer, MM
Schauer, JJ
Solomon, PA
Artamonova, M
Chen, BB
Imashev, SA
Carmichael, GR
AF Dewan, Nitika
Majestic, Brian J.
Ketterer, Michael E.
Miller-Schulze, Justin P.
Shafer, Martin M.
Schauer, James J.
Solomon, Paul A.
Artamonova, Maria
Chen, Boris B.
Imashev, Sanjar A.
Carmichael, Gregory R.
BE Evans, KR
RobertsKirchhoff, ES
Benvenuto, MA
Lanigan, KC
RihanaAbdallah, A
TI Tracing Dust Sources Using Stable Lead and Strontium Isotopes in Central
Asia
SO TRACE MATERIALS IN AIR, SOIL, AND WATER
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Trace Materials in Air, Soil, and Water at the 249th
American-Chemical-Society National Meeting
CY MAR 22-26, 2015
CL Denver, CO
SP Amer Chem Soc, Div Environm Chem Inc
ID AIRBORNE PARTICULATE MATTER; DEPOSITION; AEROSOLS; TRACERS; PB;
PARTICLES; EVOLUTION; POLLUTION; METALS; FRANCE
AB From 1960 to 2014, the Aral Sea's surface area has receded about 90% in size from 68,000 km(2) to 8,444 km(2). Consequently, newly exposed sediments are resuspended by the wind and are now a source of atmospheric particulate matter in Central Asia, which may have an impact on human health and climate. In this study, strontium (Sr) and lead (Pb) stable isotopic ratios, along with other elemental compositions, are used to determine if the Aral Sea sediments are an important source of air pollution to Central Asia. Ambient particulate matter with aerodynamic diameter < 10 mu m (PM10) samples were collected every other day and included dust and non-dust events at the Bishkek and LIDAR (in Teploklyuchenka) in Kyrgyzstan. Soil samples also were collected in the vicinity of the air sampling sites, resuspended, and sized as PM10 for chemical analysis. The average Sr-87/Sr-86 ratio for the Aral Sea sediments was 0.70992 (range, 0.70951 - 0.71064), which is less radiogenic than the surface soils in Kyrgyzstan showing an average ratio of 0.71579 (range, 0.71448 - 0.71739). In contrast, the airborne PM10 collected in Kyrgyzstan had an average 87Sr/86Sr ratio of 0.71177 (range, 0.70946 - 0.71335), which is between the two ratios, indicating a possible mixture of sources. However, no differences in Sr ratios were observed between dust and non-dust events, which implies that the impact of Aral Sea sediments on the sampling sites is minimal. The element enrichment factors and stable Pb isotope ratios are employed to further understand the source of PM10 to. Airborne PM10 are characterized by enrichments in elements like As, Cd, Cu, Mo, Pb, and Zn at both sampling sites. The mean (K/Pb) ratio for aerosols is similar to 45 and for soils is similar to 800, which suggest that the aerosols contain a significant fraction of anthropogenic source of airborne Pb in Kyrgyzstan. Pb-208/Pb-206 ratios are higher for aerosols compared to the Kyrgyzstan soils and Aral Sea sediments also suggesting that Pb is most likely present due to anthropogenic sources.
C1 [Dewan, Nitika; Majestic, Brian J.] Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA.
[Ketterer, Michael E.] Metropolitan State Univ Denver, Dept Chem, Denver, CO 80204 USA.
[Miller-Schulze, Justin P.] Calif State Univ Sacramento, Dept Chem, Sacramento, CA 95819 USA.
[Shafer, Martin M.; Schauer, James J.] Wisconsin State Lab Hyg, Madison, WI 53718 USA.
[Shafer, Martin M.; Schauer, James J.] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI 53706 USA.
[Solomon, Paul A.] US EPA, Off Res & Dev, Las Vegas, NV 89193 USA.
[Artamonova, Maria] Russian Acad Sci, Inst Atmospher Phys, Moscow 109017, Russia.
[Chen, Boris B.; Imashev, Sanjar A.] Kyrgyz Russian Slav Univ, Bishkek 720000, Kyrgyzstan.
[Carmichael, Gregory R.] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA.
RP Majestic, BJ (reprint author), Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA.
EM brian.majestic@du.edu
RI Imashev, Sanjar/I-7667-2016
OI Imashev, Sanjar/0000-0003-3293-3764
NR 36
TC 0
Z9 0
U1 3
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3110-8
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1210
BP 79
EP 98
PG 20
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA BE3SA
UT WOS:000371198800004
ER
PT S
AU Wheeler, WJ
AF Wheeler, William J.
BE Johnston, RJ
Rolfe, J
Rosenberger, RS
Brouwer, R
TI Benefit Transfer for Water Quality Regulatory Rulemaking in the United
States
SO BENEFIT TRANSFER OF ENVIRONMENTAL AND RESOURCE VALUES: A GUIDE FOR
RESEARCHERS AND PRACTITIONERS
SE Economics of Non-Market Goods and Resources
LA English
DT Article; Book Chapter
DE Water quality valuation; Regulatory impact analysis; Benefit transfer
ID WILLINGNESS-TO-PAY; IMPROVEMENTS; METAANALYSIS; VALUATION
AB This chapter describes the use of benefit transfer in Regulatory Impact Analyses for surface water quality regulations at the U.S. Environmental Protection Agency (EPA). It begins by explaining the regulatory framework at the EPA and existing guidance on the use of benefit transfer. It then describes how benefit transfer has been applied in practice for water quality RIAs and how that practice has changed over time: from the use of unit value transfers to more sophisticated function and meta-analytic transfers. The chapter concludes with observations about the practical application of benefit transfer methods at the EPA and how this practice diverges from the academic literature.
C1 [Wheeler, William J.] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Wheeler, WJ (reprint author), US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
EM Wheeler.william@epa.gov
NR 59
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1571-487X
BN 978-94-017-9930-0; 978-94-017-9929-4
J9 ECON NON-MARK GOOD
PY 2015
VL 14
BP 101
EP 115
DI 10.1007/978-94-017-9930-0_6
D2 10.1007/978-94-017-9930-0
PG 15
WC Economics; Environmental Studies
SC Business & Economics; Environmental Sciences & Ecology
GA BE1PO
UT WOS:000368358100007
ER
PT S
AU Luo, PP
Apip
He, B
Takara, K
Duan, WL
Hu, MC
Nover, D
AF Luo, Pingping
Apip
He, Bin
Takara, Kaoru
Duan, Weili
Hu, Maochuan
Nover, Daniel
BE Li, J
Yang, X
TI Modelling Shallow Landslide Risk Using GIS and a Distributed
Hydro-geotechnical Model
SO MONITORING AND MODELING OF GLOBAL CHANGES: A GEOMATICS PERSPECTIVE
SE Springer Remote Sensing Photogrammetry
LA English
DT Article; Book Chapter
DE GIS; Distributed hydro-geotechnical model; Shallow landslide risk;
Probability; Kyushu Island
ID PHYSICALLY-BASED MODEL; HAZARD; SCALE
AB GIS and distributed hydrological models are important tools for shallow landslide prediction, particularly as such disasters are exacerbated by global change driven changes in precipitation regimes. The main objective of this chapter is to outline a detailed methodology for shallow landslide risk assessment using GIS and a hydrological model. We have developed a method to assess shallow landslide risk using GIS tools and a distributed hydrological model and further used this method to analyze the probability of shallow landslides in a case study. The physically based distributed landslide model was developed by integrating a grid-based distributed kinematic wave rainfall-runoff model combined with an infinite slope stability module. Application of the model to assess shallow landslide risk using rainfall data for Kyushu Island shows that the model can successfully predict the effect of rainfall distribution and intensity on the driving variables that trigger shallow landslides. The modeling system has broad applicability for shallow landslide prediction and warning.
C1 [Luo, Pingping] United Nations Univ, Inst Adv Study Sustainabil UNU IAS, Shibuya Ku, Tokyo, Japan.
[Luo, Pingping; Takara, Kaoru] Kyoto Univ, DPRI, Uji, Kyoto, Japan.
[Apip] Indonesian Inst Sci LIPI, Limnol Res Ctr, Cibinong, Indonesia.
[He, Bin; Duan, Weili] Chinese Acad Sci, Nanjing Inst Geog & Limnol, Key Lab Watershed Geog Sci, Nanjing, Jiangsu, Peoples R China.
[Hu, Maochuan] Kyoto Univ, Grad Sch Engn, Dept Civil & Earth Resources Engn, Nishikyo Ku, Kyoto 6158530, Japan.
[Nover, Daniel] US EPA, Global Change Res Program, Washington, DC 20460 USA.
RP Luo, PP (reprint author), United Nations Univ, Inst Adv Study Sustainabil UNU IAS, Shibuya Ku, Tokyo, Japan.
EM luoping198121@gmail.com; apip@limnologi.lipi.go.id; hebin@niglas.ac.cn;
takara.kaoru.7v@kyoto-u.ac.jp; wlduan@nislas.ac.cn; hu-maochuan@163.com;
dmnover@gmail.com
NR 23
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 2198-0721
BN 978-94-017-9813-6; 978-94-017-9812-9
J9 SPRING REMOTE SENS P
PY 2015
BP 221
EP 240
DI 10.1007/978-94-017-9813-6_11
D2 10.1007/978-94-017-9813-6
PG 20
WC Environmental Sciences; Remote Sensing
SC Environmental Sciences & Ecology; Remote Sensing
GA BE0OH
UT WOS:000366486500012
ER
PT B
AU Cascio, WE
AF Cascio, Wayne E.
BE Wang, H
Patterson, C
Pratico, D
Jain, MK
Yang, X
Sibinga, NES
Feinberg, MW
TI LIFE STYLE
SO ATHEROSCLEROSIS: RISKS, MECHANISMS, AND THERAPIES
LA English
DT Article; Book Chapter
ID CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; MATTER
AIR-POLLUTION; HEINZ NIXDORF RECALL; CARDIOVASCULAR-DISEASE;
ALCOHOL-CONSUMPTION; SUBCLINICAL ATHEROSCLEROSIS; ENDOTHELIAL FUNCTION;
PHYSICAL-ACTIVITY; TOBACCO-SMOKE
C1 [Cascio, Wayne E.] US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
[Cascio, Wayne E.] Univ N Carolina, Dept Med, Div Cardiol, Chapel Hill, NC USA.
RP Cascio, WE (reprint author), US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
NR 67
TC 0
Z9 0
U1 1
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-82853-3; 978-1-118-28591-6
PY 2015
BP 93
EP 103
D2 10.1002/9781118828533
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA BE2JJ
UT WOS:000369411200010
ER
PT S
AU Perkins, E
Garcia-Reyero, N
Edwards, S
Wittwehr, C
Villeneuve, D
Lyons, D
Ankley, G
AF Perkins, Edward
Garcia-Reyero, Natalia
Edwards, Stephen
Wittwehr, Clemens
Villeneuve, Daniel
Lyons, David
Ankley, Gerald
BE Hoeng, J
Peitsch, MC
TI The Adverse Outcome Pathway: A Conceptual Framework to Support Toxicity
Testing in the Twenty-First Century
SO COMPUTATIONAL SYSTEMS TOXICOLOGY
SE Methods in Pharmacology and Toxicology
LA English
DT Article; Book Chapter
DE Predictive toxicology; Ecotoxicology; Key events; Computational biology;
Network science; Risk assessment
ID MINNOW PIMEPHALES-PROMELAS; HUMAN RELEVANCE FRAMEWORK; FOLLICULAR CELL
TUMORS; EARLY FISH DEVELOPMENT; RISK-ASSESSMENT; FATHEAD MINNOW; CANCER
MODE; NETWORK INFERENCE; THYROID-HORMONE; IPCS FRAMEWORK
AB The need to rapidly characterize the risk of large numbers of chemicals has moved the traditional toxicological paradigm from animal testing to a pathway-based approach using in vitro assay systems and modeling where possible. Adverse Outcome Pathways (AOPs) provide a conceptual framework that can be used to link in vitro assay results to whole animal effects in a pathway context. AOPs are defined and examples are provided to demonstrate key characteristics of AOPs. To support development and application of AOPs, a knowledge base has been developed containing a Wiki site designed to permit documentation of AOPs in a crowd-sourced manner. Both empirical and computational methods are demonstrated to play a significant role in AOP development. The combination of computational approaches, including different modeling efforts, together with apical end points within the pathway-based framework will allow for a better understanding of the linkage of events from a molecular initiating event to a potential adverse outcome, therefore defi ning key events, AOPs, and even networks of AOPS. While these approaches are indeed very promising, the ability to understand and defi ne key events and key event relationships will remain one of the more complex and challenging efforts within AOP development. In order to make AOPs useful for risk assessment these challenges need to be understood and overcome. An interdisciplinary approach including apical and molecular measurements, computational, and modeling efforts is currently being one of the most promising approaches to ensure AOPs become the useful framework they were designed to be.
C1 [Perkins, Edward] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Edwards, Stephen; Lyons, David] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Wittwehr, Clemens] Commiss European Communities, Joint Res Ctr, Syst Toxicol Unit, I-21020 Ispra, Italy.
[Villeneuve, Daniel; Ankley, Gerald] US EPA, Midcontinent Ecol Div, Duluth, MN USA.
RP Perkins, E (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RI Lyons, David/G-3459-2011
OI Lyons, David/0000-0002-2966-5634
NR 84
TC 0
Z9 0
U1 4
U2 12
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1557-2153
BN 978-1-4939-2778-4; 978-1-4939-2777-7
J9 METHOD PHARMACOL TOX
JI Methods Pharmacol. Toxicol.
PY 2015
BP 1
EP 26
DI 10.1007/978-1-4939-2778-4_1
D2 10.1007/978-1-4939-2778-4
PG 26
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BE1QP
UT WOS:000368400200002
ER
PT S
AU Fowle, JR
AF Fowle, John Jack R., III
BE Levy, IJ
Middlecamp, CH
TI Harnessing Advances in Biology and Computing To Advance Chemistry: A
Regulatory Toxicology Perspective
SO TEACHING AND LEARNING ABOUT SUSTAINABILITY
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Sustain-Mix: Sustainabily across the Society / 248th
American-Chemical-Society Meeting and Exposition
CY AUG 10-14, 2014
CL Amer Chem Soc, Div Chem Educ, San Francisco, CA
SP Amer Chem Soc, Div Chem Educ
HO Amer Chem Soc, Div Chem Educ
ID RISK-ASSESSMENT
AB Continuing advances in high speed computing and in the understanding of the biological basis of life have enabled a systems approach to assess chemical toxicity. They provide a promise to more efficiently evaluate risk potential after chemical exposure to humans and the environment, and they also provide a promise to design sustainable chemicals and chemical products. Building on the National Research Council's 2007 report "Toxicity Testing in the 21st Century: A Vision and a Strategy" this chapter presents an overview of the multidisciplinary approaches being developed to integrate science across enabling technologies to develop a mechanistic understanding of toxicology and to use this emerging understanding to predict adverse outcomes. National and international efforts to develop a new paradigm for risk assessment will be mentioned in the context of safe food and drugs, sustainable "green" chemistry, human health and environmental protection.
C1 [Fowle, John Jack R., III] Sci Inform LLC, Pittsboro, NC 27312 USA.
[Fowle, John Jack R., III] US EPA, Washington, DC USA.
RP Fowle, JR (reprint author), Sci Inform LLC, 155 Terrells Mtn, Pittsboro, NC 27312 USA.
EM jackfowle@aol.com
NR 27
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3104-7
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1205
BP 37
EP 58
PG 22
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA BE1OS
UT WOS:000368305400004
ER
PT J
AU Moriasi, DN
Zeckoski, RW
Arnold, JG
Baffaut, CB
Malone, RW
Daggupati, P
Guzman, JA
Saraswat, D
Yuan, Y
Wilson, BW
Shirmohammadi, A
Douglas-Mankin, KR
AF Moriasi, D. N.
Zeckoski, R. W.
Arnold, J. G.
Baffaut, C. B.
Malone, R. W.
Daggupati, P.
Guzman, J. A.
Saraswat, D.
Yuan, Y.
Wilson, B. W.
Shirmohammadi, A.
Douglas-Mankin, K. R.
TI HYDROLOGIC AND WATER QUALITY MODELS: KEY CALIBRATION AND VALIDATION
TOPICS
SO TRANSACTIONS OF THE ASABE
LA English
DT Article
DE ASABE; Calibration; Guidelines; Hydrologic models; Recommendations;
Synthesis; Validation
ID GOODNESS-OF-FIT; UNCERTAINTY; PERFORMANCE; SOIL; METHODOLOGY;
GUIDELINES; SCIENCE
AB As a continuation of efforts to provide a common background and platform for development of calibration and validation (C/V) guidelines for hydrologic and water quality (H/WQ) modeling, ASABE members worked to determine critical topics related to model C/V, perform a synthesis of a previously published special collection of articles and other relevant literature, and provide topic-specific recommendations based on the synthesis as well as personal modeling expertise. This article introduces a special collection of nine research articles covering key topics related to calibration and validation of H/WQ models. The topics include: terminology, hydrologic processes and model representation, spatial and temporal scales, model parameterization, C/V strategies, sensitivity, uncertainty, performance measures and criteria, and documentation and reporting. The main objective of this introductory article is to introduce and summarize key aspects of these topics, including recommendations. Individually, the articles provide model practitioners with detailed topic-specific recommendations related to model calibration, validation, and use. Collectively, the articles present recommendations to enhance H/WQ modeling.
C1 [Moriasi, D. N.] USDA ARS, Grazinglands Res Lab, 7207 W Cheyenne St, El Reno, OK 73036 USA.
[Zeckoski, R. W.] Zeckoski Engn, Charlotte, NC USA.
[Arnold, J. G.] USDA ARS, Grassland Soil & Water Res Lab, Temple, TX USA.
[Baffaut, C. B.] USDA ARS, Cropping Syst & Water Qual Res Unit, Columbia, MO USA.
[Malone, R. W.] USDA ARS, Natl Lab Agr & Environm, Ames, IA USA.
[Daggupati, P.] Texas A&M Univ, Texas Agrilife Res, College Stn, TX USA.
[Guzman, J. A.] Waterborne Environm Inc, Champaign, IL USA.
[Saraswat, D.] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA.
[Yuan, Y.] US EPA, Off Res & Dev, NERL ESD Landscape Ecol Branch, Las Vegas, NV USA.
[Wilson, B. W.] Univ Minnesota, Dep Biosyst & Agr Engn, St Paul, MN 55455 USA.
[Shirmohammadi, A.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA.
[Shirmohammadi, A.] Univ Maryland, Maryland Agr Expt Stn, College Pk, MD 20742 USA.
[Douglas-Mankin, K. R.] US Fish & Wildlife Serv, Everglades Program Team, ARM Loxahatchee Natl Wildlife Refuge, Boynton Beach, FL USA.
RP Moriasi, DN (reprint author), USDA ARS, Grazinglands Res Lab, 7207 W Cheyenne St, El Reno, OK 73036 USA.
EM daniel.moriasi@ars.usda.gov
RI Daggupati, Prasad/D-8886-2017
OI Daggupati, Prasad/0000-0002-7044-3435
NR 61
TC 1
Z9 1
U1 6
U2 12
PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS
PI ST JOSEPH
PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA
SN 2151-0032
EI 2151-0040
J9 T ASABE
JI Trans. ASABE
PY 2015
VL 58
IS 6
BP 1609
EP 1618
PG 10
WC Agricultural Engineering
SC Agriculture
GA DB2MC
UT WOS:000368341900016
ER
PT J
AU Yuan, Y
Khare, Y
Wang, X
Parajuli, PB
Kisekka, I
Finsterle, S
AF Yuan, Y.
Khare, Y.
Wang, X.
Parajuli, P. B.
Kisekka, I.
Finsterle, S.
TI HYDROLOGIC AND WATER QUALITY MODELS: SENSITIVITY
SO TRANSACTIONS OF THE ASABE
LA English
DT Article
DE Hydrologic and water quality modeling; One-at-a-time; Parameters;
Sensitivity analysis; Sensitivity measures; Sensitivity methods
ID MIKE-SHE MODEL; SOIL HYDRAULIC-PROPERTIES; GLOBAL SENSITIVITY; SWAT
MODEL; UNCERTAINTY ANALYSES; SIMULATION-MODELS; PARAMETER SENSITIVITY;
DRAINMOD PREDICTIONS; GLUE METHODOLOGY; INPUT VARIABLES
AB This article is part of a collection of articles that provides a comprehensive description of hydrologic and water quality (H/WQ) model calibration and validation concepts and processes. Sensitivity analysis (SA), which is often used to quantify the strength of relationships between model inputs and outputs, is an essential evaluation of any kind of modeling. SA is crucial in H/WQ models due to various aspects involved in H/WQ modeling processes, such as empiricism, spatiotemporal scales, and complexity, that require an assessment of parameters' influence on the model's prediction. This study synthesized SA applications for 25 H/WQ models in the special collection on model use, calibration, and validation published in 2012 and provides guidance on their future applications. Commonly used SA methods are summarized along with tools to implement them. While SA was not employed for all 25 models in the special collection, a wide range of SA methods (from partial derivatives to variance-based global methods) and sensitivity measures (from scatter plots to variance decomposition measures) were used in the literature. Some model parameters were found to be important in most sensitivity applications performed for the models; however, their relative importance varied from study to study, underscoring the necessity of SA for every new model application. Nevertheless, summarizing important model parameters can still serve as a starting point for model users. Since most studies concentrated on model parameters alone; future SA applications in H/WQ modeling should also consider other inputs (climate data, boundary conditions, etc.) and non-parametric aspects, such as features and processes considered in the model.
C1 [Yuan, Y.] US EPA, Off Res & Dev, NERL ESD Landscape Ecol Branch, Las Vegas, NV 89193 USA.
[Khare, Y.] Univ Florida, Dept Agr & Biol Engn, Gainesville, FL USA.
[Wang, X.] Blackland Res & Extens Ctr, Temple, TX USA.
[Parajuli, P. B.] Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA.
[Kisekka, I.] Kansas State Univ, Southwest Area Extens, Garden City, KS USA.
[Finsterle, S.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA.
RP Yuan, Y (reprint author), POB 93478,944 East Harmon Ave, Las Vegas, NV 89119 USA.
EM yuan.yongping@epa.gov
RI Finsterle, Stefan/A-8360-2009
OI Finsterle, Stefan/0000-0002-4446-9906
NR 161
TC 8
Z9 8
U1 2
U2 7
PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS
PI ST JOSEPH
PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA
SN 2151-0032
EI 2151-0040
J9 T ASABE
JI Trans. ASABE
PY 2015
VL 58
IS 6
BP 1721
EP 1744
PG 24
WC Agricultural Engineering
SC Agriculture
GA DB2MC
UT WOS:000368341900022
ER
PT J
AU Ghio, AJ
Pavlisko, EN
Roggli, VL
AF Ghio, Andrew J.
Pavlisko, Elizabeth N.
Roggli, Victor L.
TI Iron and Iron-Related Proteins in Asbestosis
SO JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
LA English
DT Article
DE asbestos; asbestosis; iron; divalent metal transporter 1; ferritin;
metal transport protein 1
ID EPITHELIAL-CELLS; LUNG-TISSUE; PATHOGENESIS; TRANSPORTER; EXPRESSION;
GENERATION; INCREASES; CLONING; UPDATE; FE3+
AB We tested the postulate that iron homeostasis is altered among patients diagnosed to have asbestosis. Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferroportin 1 (FPN1). Slides from six individuals having pneumonectomy for lung cancer were employed as controls. Lung tissue from those patients with asbestosis demonstrated stainable iron, whereas control lung tissue did not. Staining for this metal was observed predominantly in airway and alveolar macrophages. Expression of the iron-related proteins ferritin, DMT1, and FPN1 was elevated in lung tissue from the six asbestosis patients relative to controls. This increased expression of iron-transport and iron-storage proteins was evident in both airway and alveolar epithelial cells. Asbestos bodies were abundant in lung tissue from patients diagnosed to have had asbestosis. While staining for iron, ferruginous bodies did not demonstrate uptake of antibodies for ferritin. DMT1. and FPN1. We conclude that iron homeostasis is altered in lung disease among those diagnosed to have asbestosis with an accumulation of the metal and a modified expression of iron-related proteins being evident.
C1 US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27711 USA.
Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA.
RP Ghio, AJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Human Studies Facil, Campus Box 7315,104 Mason Farm Rd, Chapel Hill, NC 27711 USA.
EM ghio.andy@epa.gov
FU US Environmental Protection Agency
FX This investigation was funded by the US Environmental Protection Agency.
This report has been reviewed by the National Health and Environmental
Effects Research Laboratory, US Environmental Protection Agency and
approved for publication. Approval does not signify that the contents
necessarily reflect the views and policies of the agency nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 28
TC 0
Z9 0
U1 1
U2 2
PU BEGELL HOUSE INC
PI DANBURY
PA 50 NORTH ST, DANBURY, CT 06810 USA
SN 0731-8898
EI 2162-6537
J9 J ENVIRON PATHOL TOX
JI J. Environ. Pathol. Toxicol. Oncol.
PY 2015
VL 34
IS 4
BP 277
EP 285
DI 10.1615/JEnvironPatholToxicolOncol.2015013397
PG 9
WC Toxicology
SC Toxicology
GA DB3BM
UT WOS:000368384600001
PM 26756421
ER
PT J
AU Cabezas, H
Heckl, I
Bertok, B
Friedler, F
AF Cabezas, Heriberto
Heckl, Istvan
Bertok, Botond
Friedler, Ferenc
TI Use the P-graph Framework to Design Supply Chains for Sustainability
SO CHEMICAL ENGINEERING PROGRESS
LA English
DT Editorial Material
ID UNCERTAINTY
C1 [Cabezas, Heriberto] US EPA, Washington, DC 20004 USA.
[Cabezas, Heriberto; Heckl, Istvan; Bertok, Botond; Friedler, Ferenc] Univ Pannonia, Pannonia, Hungary.
RP Cabezas, H (reprint author), US EPA, Washington, DC 20004 USA.
NR 14
TC 4
Z9 4
U1 0
U2 0
PU AMER INST CHEMICAL ENGINEERS
PI NEW YORK
PA 3 PARK AVE, NEW YORK, NY 10016-5901 USA
SN 0360-7275
EI 1945-0710
J9 CHEM ENG PROG
JI Chem. Eng. Prog.
PD JAN
PY 2015
VL 111
IS 1
BP 41
EP 47
PG 7
WC Engineering, Chemical
SC Engineering
GA DA5TI
UT WOS:000367865100016
ER
PT J
AU Yu, F
Luo, G
Pryor, SC
Pillai, PR
Lee, SH
Ortega, J
Schwab, JJ
Hallar, AG
Leaitch, WR
Aneja, VP
Smith, JN
Walker, JT
Hogrefe, O
Demerjian, KL
AF Yu, F.
Luo, G.
Pryor, S. C.
Pillai, P. R.
Lee, S. H.
Ortega, J.
Schwab, J. J.
Hallar, A. G.
Leaitch, W. R.
Aneja, V. P.
Smith, J. N.
Walker, J. T.
Hogrefe, O.
Demerjian, K. L.
TI Spring and summer contrast in new particle formation over nine forest
areas in North America
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; SIZE-DISTRIBUTION; ATMOSPHERIC PARTICLES;
OXIDATION-PRODUCTS; NUCLEATION; MODEL; GROWTH; RATES; ACID; UNCERTAINTY
AB Recent laboratory chamber studies indicate a significant role for highly oxidized low-volatility organics in new particle formation (NPF), but the actual role of these highly oxidized low-volatility organics in atmospheric NPF remains uncertain. Here, particle size distributions (PSDs) measured in nine forest areas in North America are used to characterize the occurrence and intensity of NPF and to evaluate model simulations using an empirical formulation in which formation rate is a function of the concentrations of sulfuric acid and low-volatility organics from alpha-pinene oxidation (Nucl-Org), and using an ion-mediated nucleation mechanism (excluding organics) (Nucl-IMN). On average, NPF occurred on similar to 70% of days during March for the four forest sites with springtime PSD measurements, while NPF occurred on only similar to 10% of days in July for all nine forest sites. Both Nucl-Org and Nucl-IMN schemes capture the observed high frequency of NPF in spring, but the Nucl-Org scheme significantly overpredicts while the Nucl-IMN scheme slightly underpredicts NPF and particle number concentrations in summer. Statistical analyses of observed and simulated ultrafine particle number concentrations and frequency of NPF events indicate that the scheme without organics agrees better overall with observations. The two schemes predict quite different nucleation rates (including their spatial patterns), concentrations of cloud condensation nuclei, and aerosol first indirect radiative forcing in North America, highlighting the need to reduce NPF uncertainties in regional and global earth system models.
C1 [Yu, F.; Luo, G.; Schwab, J. J.; Hogrefe, O.; Demerjian, K. L.] SUNY Albany, Atmospher Sci Res Ctr, Albany, NY 12203 USA.
[Luo, G.] Cornell Univ, Dept Earth & Atmospher Sci, Ithaca, NY 14853 USA.
[Pryor, S. C.; Aneja, V. P.; Walker, J. T.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Lee, S. H.] Kent State Univ, Coll Publ Hlth, Kent, OH 44242 USA.
[Ortega, J.; Smith, J. N.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Hallar, A. G.] Desert Res Inst, Storm Peak Lab, Steamboat Springs, CO 80488 USA.
[Leaitch, W. R.] Environm Canada, Sci & Technol Branch, Toronto, ON, Canada.
[Smith, J. N.] Univ Eastern Finland, Dept Appl Phys, Kuopio 70211, Finland.
[Walker, J. T.] US EPA, Off Res & Dev, Durham, NC 27711 USA.
RP Yu, F (reprint author), SUNY Albany, Atmospher Sci Res Ctr, 251 Fuller Rd, Albany, NY 12203 USA.
EM fyu@albany.edu
RI Yu, Fangqun/F-3708-2011; Hallar, Anna Gannet/I-9104-2012; Smith,
James/C-5614-2008;
OI Yu, Fangqun/0000-0003-0874-4883; Hallar, Anna
Gannet/0000-0001-9972-0056; Smith, James/0000-0003-4677-8224; Pryor,
S.C./0000-0003-4847-3440
FU NASA [NNX13AK20G, NNX11AQ72G]; US National Science Foundation (NSF); NSF
[1517365]; US Department of Energy [DE-SC0011664]; NASA's Atmospheric
Chemistry Modeling and Analysis Program
FX This study was supported by NASA under grants NNX13AK20G and NNX11AQ72G,
and the US National Science Foundation (NSF). S. C. Pryor acknowledges
financial support from NSF (no. 1517365). J. J. Schwab acknowledges
funding from the US Department of Energy, contract DE-SC0011664. The
National Center for Atmospheric Research is supported by the US National
Science Foundation. The Steamboat Ski Resort provided logistical support
and in-kind donations to Storm Peak Laboratory. The Desert Research
Institute, which owns and operates Storm Peak Laboratory, is a permittee
of the Medicine-Bow Routt National Forests and is an equal opportunity
service provider and employer. Ian McCubbin provided technical
assistance with the maintenance and data quality control for the aerosol
instruments at SPL, and we are grateful. The GEOS-Chem model is managed
by the Atmospheric Chemistry Modeling Group at Harvard University with
support from NASA's Atmospheric Chemistry Modeling and Analysis Program.
NR 44
TC 3
Z9 3
U1 3
U2 11
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 24
BP 13993
EP 14003
DI 10.5194/acp-15-13993-2015
PG 11
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CZ8YE
UT WOS:000367384200009
ER
PT J
AU Shephard, MW
McLinden, CA
Cady-Pereira, KE
Luo, M
Moussa, SG
Leithead, A
Liggio, J
Staebler, RM
Akingunola, A
Makar, P
Lehr, P
Zhang, J
Henze, DK
Millet, DB
Bash, JO
Zhu, L
Wells, KC
Capps, SL
Chaliyakunnel, S
Gordon, M
Hayden, K
Brook, JR
Wolde, M
Li, SM
AF Shephard, M. W.
McLinden, C. A.
Cady-Pereira, K. E.
Luo, M.
Moussa, S. G.
Leithead, A.
Liggio, J.
Staebler, R. M.
Akingunola, A.
Makar, P.
Lehr, P.
Zhang, J.
Henze, D. K.
Millet, D. B.
Bash, J. O.
Zhu, L.
Wells, K. C.
Capps, S. L.
Chaliyakunnel, S.
Gordon, M.
Hayden, K.
Brook, J. R.
Wolde, M.
Li, S. -M.
TI Tropospheric Emission Spectrometer (TES) satellite observations of
ammonia, methanol, formic acid, and carbon monoxide over the Canadian
oil sands: validation and model evaluation
SO ATMOSPHERIC MEASUREMENT TECHNIQUES
LA English
DT Article
ID REGIONAL AIR-QUALITY; IONIZATION MASS-SPECTROMETER; BIOMASS BURNING
PLUMES; ACETIC-ACIDS; ATMOSPHERIC METHANOL; ORGANIC-COMPOUNDS; GLOBAL
DISTRIBUTIONS; RETRIEVAL ALGORITHM; BIOGENIC EMISSIONS; DAILY MORTALITY
AB The wealth of air quality information provided by satellite infrared observations of ammonia (NH3), carbon monoxide (CO), formic acid (HCOOH), and methanol (CH3OH) is currently being explored and used for a number of applications, especially at regional or global scales. These applications include air quality monitoring, trend analysis, emissions, and model evaluation. This study provides one of the first direct validations of Tropospheric Emission Spectrometer (TES) satellite-retrieved profiles of NH3, CH3OH, and HCOOH through comparisons with coincident aircraft profiles. The comparisons are performed over the Canadian oil sands region during the intensive field campaign (August-September, 2013) in support of the Joint Canada-Alberta Implementation Plan for Oil Sands Monitoring (JOSM). The satellite/aircraft comparisons over this region during this period produced errors of (i) +0.08 +/- 0.25 ppbv for NH3, (ii) +7.5 +/- 23 ppbv for CO, (iii) +0.19 +/- 0.46 ppbv for HCOOH, and (iv) 1.1 +/- 0.39 ppbv for CH3OH. These values mostly agree with previously estimated retrieval errors; however, the relatively large negative bias in CH3OH and the significantly greater positive bias for larger HCOOH and CO values observed during this study warrant further investigation. Satellite and aircraft ammonia observations during the field campaign are also used in an initial effort to perform preliminary evaluations of Environment Canada's Global Environmental Multi-scale-Modelling Air quality and CHemistry (GEM-MACH) air quality modelling system at high resolution (2.5 +/- 2.5 km(2). These initial results indicate a model underprediction of similar to 0.6 ppbv (similar to 60 %) for NH3, during the field campaign period. The TES/model CO comparison differences are similar to+20 ppbv (similar to +20 %), but given that under these conditions the TES/aircraft comparisons also show a small positive TES CO bias indicates that the overall model underprediction of CO is closer to similar to 10% at 681 hPa (similar to 3 km) during this period.
C1 [Shephard, M. W.; McLinden, C. A.; Moussa, S. G.; Leithead, A.; Liggio, J.; Staebler, R. M.; Akingunola, A.; Makar, P.; Lehr, P.; Zhang, J.; Gordon, M.; Hayden, K.; Brook, J. R.; Li, S. -M.] Environm Canada, Toronto, ON, Canada.
[Cady-Pereira, K. E.] AER, Lexington, MA USA.
[Luo, M.] CALTECH, Jet Prop Lab, Pasadena, CA USA.
[Henze, D. K.; Capps, S. L.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
[Millet, D. B.; Wells, K. C.; Chaliyakunnel, S.] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA.
[Bash, J. O.; Capps, S. L.] US EPA, Res Triangle Pk, NC 27711 USA.
[Zhu, L.] Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA.
[Gordon, M.] York Univ, Dept Earth & Space Sci Engn, Toronto, ON M3J 2R7, Canada.
[Wolde, M.] Natl Res Council NRC Canada, Ottawa, ON, Canada.
RP Shephard, MW (reprint author), Environm Canada, Toronto, ON, Canada.
EM mark.shephard@ec.gc.ca
RI Millet, Dylan/G-5832-2012; Capps, Shannon/E-5602-2017
OI Capps, Shannon/0000-0002-6872-6604
FU NSF [1148951]; Joint Canada-Alberta Implementation Plan for Oil Sands
Monitoring; Clean Air Regulatory Agenda (CARA); NASA ACMAP [NNX10AG63G]
FX We would like to thank Susan S. Kulawik for helping provide us with the
original updated TES version 6 lite files and Craig Stroud for his
helpful discussions and support with the back-trajectory analysis. We
would like to acknowledge other members of the aircraft team for their
contributions to the airborne measurements used to validate the
satellite observations, in particular Andrew Budden, Stewart Cober,
Andrea Darlington, Andrew Elford, Anthony Liu, Peter Liu, Aaron McCay,
Robert McLaren, Bill McMurty, Richard L. Mittermeier, Julie Narayan,
Jason O'Brien, Andrew Sheppard, Ka Sung, Danny Wang, Mohammad Wasey, and
the National Research Council Flight Research Laboratory team. We would
also like thank the other members of the oil sands modelling working
group for their insights on the initial GEM-MACH ammonia simulations
over the oil sands region, in particular Michael Moran. Work at the
University of Minnesota was supported by NSF (grant no. 1148951).
Although this work was reviewed by EPA and approved for publication, it
may not necessarily reflect official agency policy. This study was
supported in part by the Joint Canada-Alberta Implementation Plan for
Oil Sands Monitoring, the Clean Air Regulatory Agenda (CARA), and NASA
ACMAP (grant no. NNX10AG63G).
NR 113
TC 4
Z9 4
U1 8
U2 15
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1867-1381
EI 1867-8548
J9 ATMOS MEAS TECH
JI Atmos. Meas. Tech.
PY 2015
VL 8
IS 12
BP 5189
EP 5211
DI 10.5194/amt-8-5189-2015
PG 23
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CZ8YI
UT WOS:000367384600011
ER
PT J
AU Baig, RBN
Nadagouda, MN
Varma, RS
AF Baig, R. B. Nasir
Nadagouda, Mallikarjuna N.
Varma, Rajender S.
TI Cyclic Sulfamidate Enabled Syntheses of Amino Acids, Peptides,
Carbohydrates, and Natural Products
SO ALDRICHIMICA ACTA
LA English
DT Article
DE regiospecific; stereospecific; ring-opening; unnatural amino acid;
chiral building block; natural product; cyclic sulfamidate
ID C-H AMINATION; CATALYZED INTRAMOLECULAR AMIDATION; ASYMMETRIC TRANSFER
HYDROGENATION; ALPHA-PHOSPHONO LACTAMS; STEREOSELECTIVE-SYNTHESIS;
ENANTIOSELECTIVE SYNTHESIS; SULFAMATE ESTERS; BURGESS REAGENT;
NUCLEOPHILIC DISPLACEMENTS; EFFICIENT SYNTHESIS
AB This article reviews the emergence of cyclic sulfamidates as versatile intermediates for the synthesis of unnatural amino acids, chalcogen peptides, modified sugars, drugs and drug candidates, and important natural products.
C1 [Baig, R. B. Nasir; Nadagouda, Mallikarjuna N.; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Baig, RBN (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@epa.gov
FU Postgraduate Research Program at the National Risk Management Research
Laboratory
FX R. B. Nasir Baig was supported by the Postgraduate Research Program at
the National Risk Management Research Laboratory administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 93
TC 0
Z9 0
U1 3
U2 5
PU ALDRICH CHEMICAL CO INC
PI MILWAUKEE
PA 1001 WEST SAINT PAUL AVE, MILWAUKEE, WI 53233 USA
SN 0002-5100
J9 ALDRICHIM ACTA
JI Aldrichimica Acta
PY 2015
VL 48
IS 3
BP 71
EP 80
PG 10
WC Chemistry, Organic
SC Chemistry
GA CZ2VL
UT WOS:000366962600002
ER
PT J
AU Lalley, J
Han, C
Mohan, GR
Dionysiou, DD
Speth, TF
Garland, J
Nadagouda, MN
AF Lalley, Jacob
Han, Changseok
Mohan, Gayathri Ram
Dionysiou, Dionysios D.
Speth, Thomas F.
Garland, Jay
Nadagouda, Mallikarjuna N.
TI Phosphate removal using modified Bayoxide (R) E33 adsorption media
SO ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
LA English
DT Article
ID GLOBAL PHOSPHORUS FLOWS; AQUEOUS-SOLUTION; RED MUD; IRON-OXIDES;
WASTE-WATER; STEEL SLAG; FLY-ASH; GOETHITE; ADSORBENT; SURFACE
AB The adsorption of phosphate onto modified Bayoxide (R) E33 (E33) and underlying mechanisms were comparatively investigated by batch kinetics, sorption isotherms, rapid small-scale column tests, and material characterization. Synthesis of modified E33 was conducted by the addition of manganese and silver nanoparticles on the surface of the goethite (alpha-FeOOH)-based E33. Upon successful adsorbent synthesis, the materials were characterized using SEM, TEM, XRD, EDX, HR-TEM, and BET surface area analysis. The adsorption kinetics is described by a fast initial adsorption stage followed by a slow adsorption stage, complying with pseudo second-order kinetics and Elovich kinetics. Sorption isotherms revealed that the equilibrium capacity of one of the modified adsorbents (E33/AgII) exceeded that of unmodified E33 likely due to its increased BET surface area. Column experiments confirmed the results for adsorption kinetics and equilibrium of phosphate sorption onto E33 and modified E33. This suggests that media modification has the potential to improve phosphate removal properties.
C1 [Lalley, Jacob; Han, Changseok; Speth, Thomas F.; Nadagouda, Mallikarjuna N.] US EPA, ORD, NRMRL, WSWRD,WQMB, Cincinnati, OH 45268 USA.
[Lalley, Jacob; Dionysiou, Dionysios D.] Univ Cincinnati, DBCEE, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
[Han, Changseok; Mohan, Gayathri Ram] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
[Garland, Jay] US EPA, ORD, NERL, MCEARD, Cincinnati, OH 45268 USA.
RP Nadagouda, MN (reprint author), US EPA, ORD, NRMRL, WSWRD,WQMB, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA.
EM Nadagouda.mallikarjuna@epa.gov
NR 64
TC 6
Z9 6
U1 3
U2 6
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2053-1400
EI 2053-1419
J9 ENVIRON SCI-WAT RES
JI Environ. Sci.-Wat. Res. Technol.
PY 2015
VL 1
IS 1
BP 96
EP 107
DI 10.1039/c4ew00020j
PG 12
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA CZ1UA
UT WOS:000366889800013
ER
PT J
AU Zhu, L
Henze, D
Bash, J
Jeong, GR
Cady-Pereira, K
Shephard, M
Luo, M
Paulot, F
Capps, S
AF Zhu, L.
Henze, D.
Bash, J.
Jeong, G. -R.
Cady-Pereira, K.
Shephard, M.
Luo, M.
Paulot, F.
Capps, S.
TI Global evaluation of ammonia bidirectional exchange and livestock
diurnal variation schemes
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID BIOSPHERE-ATMOSPHERE EXCHANGE; AIR-QUALITY MODEL; UNITED-STATES;
SATELLITE-OBSERVATIONS; DATA ASSIMILATION; HIGH-RESOLUTION; GEOS-CHEM;
TROPOSPHERIC CHEMISTRY; NITROGEN DEPOSITION; PARTICULATE MATTER
AB Bidirectional air-surface exchange of ammonia (NH3) has been neglected in many air quality models. In this study, we implement the bidirectional exchange of NH3 in the GEOS-Chem global chemical transport model. We also introduce an updated diurnal variability scheme for NH3 livestock emissions and evaluate the recently developed MASAGE_NH3 bottom-up inventory. While updated diurnal variability improves comparison of modeled-to-hourly in situ measurements in the southeastern USA, NH3 concentrations decrease throughout the globe, up to 17 ppb in India and southeastern China, with corresponding decreases in aerosol nitrate by up to 7 mu g m(-3). The ammonium (NH4+) soil pool in the bidirectional exchange model largely extends the NH3 lifetime in the atmosphere. Including bidirectional exchange generally increases NH3 gross emissions (7.1 %) and surface concentrations (up to 3.9 ppb) throughout the globe in July, except in India and southeastern China. In April and October, it decreases NH3 gross emissions in the Northern Hemisphere (e.g., 43.6 % in April in China) and increases NH3 gross emissions in the Southern Hemisphere. Bidirectional exchange does not largely impact NH4+ wet deposition overall. While bidirectional exchange is fundamentally a better representation of NH3 emissions from fertilizers, emissions from primary sources are still underestimated and thus significant model biases remain when compared to in situ measurements in the USA. The adjoint of bidirectional exchange has also been developed for the GEOS-Chem model and is used to investigate the sensitivity of NH3 concentrations with respect to soil pH and fertilizer application rate. This study thus lays the groundwork for future inverse modeling studies to more directly constrain these physical processes rather than tuning bulk unidirectional NH3 emissions.
C1 [Zhu, L.; Henze, D.; Jeong, G. -R.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
[Bash, J.; Jeong, G. -R.; Capps, S.] US EPA, Res Triangle Pk, NC USA.
[Cady-Pereira, K.] Atmospher & Environm Res Inc, Lexington, MA USA.
[Shephard, M.] Environm Canada, Toronto, ON, Canada.
[Luo, M.] CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA.
[Paulot, F.] Princeton Univ, Program Atmospher & Ocean Sci, Princeton, NJ 08544 USA.
[Paulot, F.] NOAA, Geophys Fluid Dynam Lab, Princeton, NJ USA.
RP Henze, D (reprint author), Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
EM daven.henze@colorado.edu
RI Chem, GEOS/C-5595-2014; Capps, Shannon/E-5602-2017
OI Capps, Shannon/0000-0002-6872-6604
FU NASA [NNX09AN77G, NNX10AG63G]; EPA STAR award [RD834559]
FX This work is supported by NASA grants NNX09AN77G and NNX10AG63G and EPA
STAR award RD834559. While this manuscript has been reviewed by the
Environmental Protection Agency and approved for publication, it may not
reflect official agency views or policies.
NR 68
TC 12
Z9 12
U1 3
U2 24
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 22
BP 12823
EP 12843
DI 10.5194/acp-15-12823-2015
PG 21
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CX8TM
UT WOS:000365977100008
ER
PT J
AU Gantt, B
Kelly, JT
Bash, JO
AF Gantt, B.
Kelly, J. T.
Bash, J. O.
TI Updating sea spray aerosol emissions in the Community Multiscale Air
Quality (CMAQ) model version 5.0.2
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID PRIMARY MARINE AEROSOL; BOUNDARY-LAYER; SALT AEROSOL;
CHEMICAL-COMPOSITION; RELATIVE-HUMIDITY; WATER TEMPERATURE; SIZE
DISTRIBUTION; UNITED-STATES; NITRIC-ACID; PARTICLES
AB Sea spray aerosols (SSAs) impact the particle mass concentration and gas-particle partitioning in coastal environments, with implications for human and ecosystem health. Model evaluations of SSA emissions have mainly focused on the global scale, but regional-scale evaluations are also important due to the localized impact of SSAs on atmospheric chemistry near the coast. In this study, SSA emissions in the Community Multiscale Air Quality (CMAQ) model were updated to enhance the fine-mode size distribution, include sea surface temperature (SST) dependency, and reduce surf-enhanced emissions. Predictions from the updated CMAQ model and those of the previous release version, CMAQv5.0.2, were evaluated using several coastal and national observational data sets in the continental US. The updated emissions generally reduced model underestimates of sodium, chloride, and nitrate surface concentrations for coastal sites in the Bay Regional Atmospheric Chemistry Experiment (BRACE) near Tampa, Florida. Including SST dependency to the SSA emission parameterization led to increased sodium concentrations in the southeastern US and decreased concentrations along parts of the Pacific coast and northeastern US. The influence of sodium on the gas-particle partitioning of nitrate resulted in higher nitrate particle concentrations in many coastal urban areas due to increased condensation of nitric acid in the updated simulations, potentially affecting the predicted nitrogen deposition in sensitive ecosystems. Application of the updated SSA emissions to the California Research at the Nexus of Air Quality and Climate Change (CalNex) study period resulted in a modest improvement in the predicted surface concentration of sodium and nitrate at several central and southern California coastal sites. This update of SSA emissions enabled a more realistic simulation of the atmospheric chemistry in coastal environments where marine air mixes with urban pollution.
C1 [Gantt, B.; Bash, J. O.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Gantt, B.; Kelly, J. T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Bash, JO (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM bash.jesse@epa.gov
RI Kelly, James/F-8135-2010
OI Kelly, James/0000-0001-6574-5714
FU United States Environmental Protection Agency (EPA) through Office of
Research and Development; Office of Research and Development, US EPA
FX We would like to acknowledge use of Rodney Weber's continuous
PM2.5 composition measurements from the Pasadena ground site
and monitor data from the IMPROVE and CSN networks. We also thank
Christopher Nolte for help in the analysis of the BRACE data set/aerosol
size distributions, Kirk Baker for help in the development of the CalNex
platform, and the two anonymous reviewers for their constructive
comments. The United States Environmental Protection Agency (EPA)
through its Office of Research and Development funded and managed the
research described here. This paper has been subjected to the Agency's
administrative review and approved for publication. B. Gantt is
supported by an appointment to the Research Participation Program at the
Office of Research and Development, US EPA, administered by ORISE.
NR 65
TC 5
Z9 5
U1 1
U2 10
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 11
BP 3733
EP 3746
DI 10.5194/gmd-8-3733-2015
PG 14
WC Geosciences, Multidisciplinary
SC Geology
GA CX8UQ
UT WOS:000365980100013
ER
PT J
AU Mearns, AJ
Reish, DJ
Oshida, PS
Ginn, T
Rempel-Hester, MA
Arthur, C
Rutherford, N
Pryor, R
AF Mearns, Alan J.
Reish, Donald J.
Oshida, Philip S.
Ginn, Thomas
Rempel-Hester, Mary Ann
Arthur, Courtney
Rutherford, Nicolle
Pryor, Rachel
TI Effects of Pollution on Marine Organisms
SO WATER ENVIRONMENT RESEARCH
LA English
DT Article
DE Tissue residues; toxicity; bioaccumulation; biomagnification;
biomarkers; sediment quality; ecological risk assessment; endocrine
disrupters; nano particles; POPs; PCBs; PAHs; PBDEs; radionuclides;
pharmaceuticals; personal care products; trace metals; pesticides;
biomarkers; marine biocides; oil spills; dispersants; sewage; debris;
dredging; eutrophication; human disturbance; Arctic; Antarctic
ID DEEP-WATER-HORIZON; GULF-OF-MEXICO; POLYCYCLIC AROMATIC-HYDROCARBONS;
MEDAKA ORYZIAS-MELASTIGMA; COPEPOD TIGRIOPUS-JAPONICUS; POLYCHAETE
HEDISTE-DIVERSICOLOR; ENDOCRINE-DISRUPTING CHEMICALS; CLAM
VENERUPIS-PHILIPPINARUM; LOGGERHEAD SEA-TURTLES; MUSSEL PERNA-VIRIDIS
AB This review covers selected 2014 articles on the biological effects of pollutants and human physical disturbances on marine and estuarine plants, animals, ecosystems and habitats. The review, based largely on journal articles, covers field and laboratory measurement activities (bioaccumulation of contaminants, field assessment surveys, toxicity testing and biomarkers) as well as pollution issues of current interest including endocrine disrupters, emerging contaminants, wastewater discharges, dredging and disposal, etc. Special emphasis is placed on effects of oil spills and marine debris due in part to the 2010 Deepwater Horizon oil blowout in the Gulf of Mexico and the 2011 Japanese tsunami. Several topical areas reviewed in the past (ballast water and ocean acidification) were dropped this year. The focus of this review is on effects, not pollutant fate and transport. There is considerable overlap across subject areas (e.g. some bioaccumulation papers may be cited in other topical categories). Please use keyword searching of the text to locate related but distributed papers. Use this review only as a guide and please consult the original papers before citing them.
C1 [Mearns, Alan J.; Rutherford, Nicolle; Pryor, Rachel] NOAA, Emergency Response Div, Seattle, WA 98115 USA.
[Reish, Donald J.] Calif State Univ Long Beach, Dept Biol Sci, Long Beach, CA USA.
[Oshida, Philip S.] US EPA, Arlington, VA USA.
[Ginn, Thomas] Exponent Inc, Sedona, AZ USA.
[Rempel-Hester, Mary Ann] Aquat Toxicol Support, Bremerton, WA USA.
[Arthur, Courtney] Ind Econ Inc, Cambridge, MA USA.
RP Mearns, AJ (reprint author), NOAA, Emergency Response Div, 7600 Sand Point Way NE, Seattle, WA 98115 USA.
EM alan.mearns@noaa.gov
NR 406
TC 2
Z9 2
U1 44
U2 173
PU WATER ENVIRONMENT FEDERATION
PI ALEXANDRIA
PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA
SN 1061-4303
EI 1554-7531
J9 WATER ENVIRON RES
JI Water Environ. Res.
PY 2015
VL 87
IS 10
BP 1718
EP 1816
DI 10.2175/106143015X14338845156380
PG 99
WC Engineering, Environmental; Environmental Sciences; Limnology; Water
Resources
SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater
Biology; Water Resources
GA CY5TB
UT WOS:000366469200032
PM 26420104
ER
PT B
AU Pardo, LH
Robin-Abbott, MJ
Fenn, ME
Goodale, CL
Geiser, LH
Driscoll, CT
Allen, EB
Baron, JS
Bobbink, R
Bowman, WD
Clark, CM
Bowman, WD
Emmett, B
Gilliam, FS
Greaver, TL
Hall, SJ
Lilleskov, EA
Liu, LL
Lynch, JA
Nadelhoffer, KJ
Perakis, SJ
Stoddard, JL
Weathers, KC
Dennis, RL
AF Pardo, Linda H.
Robin-Abbott, Molly J.
Fenn, Mark E.
Goodale, Christine L.
Geiser, Linda H.
Driscoll, Charles T.
Allen, Edith B.
Baron, Jill S.
Bobbink, Roland
Bowman, William D.
Clark, Christopher M.
Bowman, William D.
Emmett, Bridget
Gilliam, Frank S.
Greaver, Tara L.
Hall, Sharon J.
Lilleskov, Erik A.
Liu, Lingli
Lynch, Jason A.
Nadelhoffer, Knute J.
Perakis, Steven J.
Stoddard, John L.
Weathers, Kathleen C.
Dennis, Robin L.
BE DeVries, W
Hettelingh, JP
Posch, M
TI Effects and Empirical Critical Loads of Nitrogen for Ecoregions of the
United States
SO CRITICAL LOADS AND DYNAMIC RISK ASSESSMENTS: NITROGEN, ACIDITY AND
METALS IN TERRESTRIAL AND AQUATIC ECOSYSTEMS
SE Environmental Pollution Series
LA English
DT Article; Book Chapter
ID SAN-BERNARDINO MOUNTAINS; COLORADO FRONT RANGE; TEMPERATE FOREST
ECOSYSTEMS; SOUTHERN-CALIFORNIA; DEPOSITION GRADIENT; ALPINE LAKES;
HERBACEOUS LAYER; RESOURCE REQUIREMENTS; POPULATION-DYNAMICS; MONTANE
ECOSYSTEMS
C1 [Pardo, Linda H.; Robin-Abbott, Molly J.] US Forest Serv, USDA, Burlington, VT USA.
[Fenn, Mark E.] US Forest Serv, USDA, Riverside, CA USA.
[Goodale, Christine L.] Cornell Univ, Ithaca, NY USA.
[Geiser, Linda H.] US Forest Serv, USDA, Corvallis, OR USA.
[Driscoll, Charles T.] Syracuse Univ, Syracuse, NY USA.
[Allen, Edith B.] Univ Calif Riverside, Riverside, CA 92521 USA.
[Baron, Jill S.] US Geol Survey, Ft Collins, CO USA.
[Bobbink, Roland] B WARE Res Ctr, Nijmegen, Netherlands.
[Bowman, William D.] Univ Colorado, Boulder, CO 80309 USA.
[Clark, Christopher M.; Lynch, Jason A.] US EPA, Washington, DC 20460 USA.
[Emmett, Bridget] Environm Ctr Wales, Ctr Ecol & Hydrol, Bangor, Gwynedd, Wales.
[Gilliam, Frank S.] Marshall Univ, Huntington, WV USA.
[Greaver, Tara L.; Liu, Lingli; Dennis, Robin L.] US EPA, Res Triangle Pk, NC 27711 USA.
[Hall, Sharon J.] Arizona State Univ, Tempe, AZ USA.
[Lilleskov, Erik A.] US Forest Serv, USDA, Houghton, MI USA.
[Nadelhoffer, Knute J.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Perakis, Steven J.] US Geol Survey, Corvallis, OR USA.
[Stoddard, John L.] US EPA, Corvallis, OR USA.
[Weathers, Kathleen C.] Cary Inst Ecosyst Studies, Millbrook, NY USA.
RP Pardo, LH (reprint author), US Forest Serv, USDA, Burlington, VT USA.
EM lpardo@fs.fed.us
NR 149
TC 1
Z9 1
U1 6
U2 10
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
BN 978-94-017-9508-1; 978-94-017-9507-4
J9 ENVIRON POLLUT SER
JI Environ. Pollut. Ser.
PY 2015
VL 25
BP 129
EP 169
DI 10.1007/978-94-017-9508-1_5
D2 10.1007/978-94-017-9508-1
PG 41
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BE0AL
UT WOS:000365670800006
ER
PT J
AU Gan, CM
Pleim, J
Mathur, R
Hogrefe, C
Long, CN
Xing, J
Wong, D
Gilliam, R
Wei, C
AF Gan, C. -M.
Pleim, J.
Mathur, R.
Hogrefe, C.
Long, C. N.
Xing, J.
Wong, D.
Gilliam, R.
Wei, C.
TI Assessment of long-term WRF-CMAQ simulations for understanding direct
aerosol effects on radiation "brightening" in the United States
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID NORTH-AMERICA; PART II; MODEL; TRENDS; SYSTEM; PERSPECTIVE; TERRAIN;
SEARCH; DUST
AB Long-term simulations with the coupled WRF-CMAQ (Weather Research and Forecasting-Community Multi-scale Air Quality) model have been conducted to systematically investigate the changes in anthropogenic emissions of SO2 and NOx over the past 16 years (1995-2010) across the United States (US), their impacts on anthropogenic aerosol loading over North America, and subsequent impacts on regional radiation budgets. In particular, this study attempts to determine the consequences of the changes in tropospheric aerosol burden arising from substantial reductions in emissions of SO2 and NOx associated with control measures under the Clean Air Act (CAA) especially on trends in solar radiation. Extensive analyses conducted by Gan et al. (2014a) utilizing observations (e.g., SURFRAD, CASTNET, IMPROVE, and ARM) over the past 16 years (1995-2010) indicate a shortwave (SW) radiation (both all-sky and clear-sky) "brightening" in the US. The relationship of the radiation brightening trend with decreases in the aerosol burden is less apparent in the western US. One of the main reasons for this is that the emission controls under the CAA were aimed primarily at reducing pollutants in areas violating national air quality standards, most of which were located in the eastern US, while the relatively less populated areas in the western US were less polluted at the beginning of this study period. Comparisons of model results with observations of aerosol optical depth (AOD), aerosol concentration, and radiation demonstrate that the coupled WRF-CMAQ model is capable of replicating the trends well even though it tends to underestimate the AOD. In particular, the sulfate concentration predictions were well matched with the observations. The discrepancies found in the clear-sky diffuse SW radiation are likely due to several factors such as the potential increase of ice particles associated with increasing air traffic, the definition of "clear-sky" in the radiation retrieval methodology, and aerosol semi-direct and/or indirect effects which cannot be readily isolated from the observed data.
C1 [Gan, C. -M.; Pleim, J.; Mathur, R.; Hogrefe, C.; Xing, J.; Wong, D.; Gilliam, R.] US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Long, C. N.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Long, C. N.] NOAA, Boulder, CO USA.
[Wei, C.] Max Planck Inst Chem, D-55128 Mainz, Germany.
RP Gan, CM (reprint author), US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
EM chuenmeei@gmail.com
RI wei, chao/E-4379-2011; Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
FU US EPA; US Department of Energy [IA DE-SC0003782]; US Environmental
Protection Agency [IA RW-89-9233260]; Climate Change Research Division
of the US Department of Energy; Cooperative Institute for Research in
Environmental Sciences (CIRES)
FX This research was performed while Chuen-Meei Gan held a National
Research Council Research Associateship Award at the US EPA. The
research presented in this study was supported through an interagency
agreement between the US Department of Energy (funding IA DE-SC0003782)
and the US Environmental Protection Agency (funding IA RW-89-9233260).
It has been subject to the US EPA's administrative review and approved
for publication. The authors also would like thank John Augustine from
NOAA-SURFRAD for his support and assistance in obtaining the SURFRAD
data, as well as the NOAA Earth System Research Laboratory (ESRL) Global
Monitoring Division (GMD) for their diligent efforts in operating and
maintaining the SURFRAD sites. C. N. Long acknowledges the support of
the Climate Change Research Division of the US Department of Energy as
part of the Atmospheric Radiation Measurement (ARM) and Atmospheric
System Research (ASR) programs, and the support of the Cooperative
Institute for Research in Environmental Sciences (CIRES). The authors
would like thank James Kelly from the US EPA for his comments.
NR 38
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U1 1
U2 3
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 21
BP 12193
EP 12209
DI 10.5194/acp-15-12193-2015
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CW9OV
UT WOS:000365329000005
ER
PT J
AU Gonzalez-Abraham, R
Chung, SH
Avise, J
Lamb, B
Salathe, EP
Nolte, CG
Loughlin, D
Guenther, A
Wiedinmyer, C
Duhl, T
Zhang, Y
Streets, DG
AF Gonzalez-Abraham, R.
Chung, S. H.
Avise, J.
Lamb, B.
Salathe, E. P., Jr.
Nolte, C. G.
Loughlin, D.
Guenther, A.
Wiedinmyer, C.
Duhl, T.
Zhang, Y.
Streets, D. G.
TI The effects of global change upon United States air quality
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID REGIONAL CLIMATE-CHANGE; CMAQ MODELING SYSTEM; FINE PARTICULATE MATTER;
TROPOSPHERIC OZONE; SURFACE OZONE; NORTH-AMERICA; SIMULATING CHANGES;
ISOPRENE EMISSION; PACIFIC-NORTHWEST; EASTERN US
AB To understand more fully the effects of global changes on ambient concentrations of ozone and particulate matter with aerodynamic diameter smaller than 2.5 mu m (PM2.5) in the United States (US), we conducted a comprehensive modeling effort to evaluate explicitly the effects of changes in climate, biogenic emissions, land use and global/regional anthropogenic emissions on ozone and PM2.5 concentrations and composition. Results from the ECHAM5 global climate model driven with the A1B emission scenario from the Intergovernmental Panel on Climate Change (IPCC) were downscaled using the Weather Research and Forecasting (WRF) model to provide regional meteorological fields. We developed air quality simulations using the Community Multiscale Air Quality Model (CMAQ) chemical transport model for two nested domains with 220 and 36 km horizontal grid cell resolution for a semi-hemispheric domain and a continental United States (US) domain, respectively. The semi-hemispheric domain was used to evaluate the impact of projected global emissions changes on US air quality. WRF meteorological fields were used to calculate current (2000s) and future (2050s) biogenic emissions using the Model of Emissions of Gases and Aerosols from Nature (MEGAN). For the semi-hemispheric domain CMAQ simulations, present-day global emissions inventories were used and projected to the 2050s based on the IPCC A1B scenario. Regional anthropogenic emissions were obtained from the US Environmental Protection Agency National Emission Inventory 2002 (EPA NEI2002) and projected to the future using the MARKet ALlocation (MARKAL) energy system model assuming a business as usual scenario that extends current decade emission regulations through 2050. Our results suggest that daily maximum 8 h average ozone (DM8O) concentrations will increase in a range between 2 to 12 parts per billion (ppb) across most of the continental US. The highest increase occurs in the South, Central and Midwest regions of the US due to increases in temperature, enhanced biogenic emissions and changes in land use. The model predicts an average increase of 1-6 ppb in DM8O due to projected increase in global emissions of ozone precursors. The effects of these factors are only partially offset by reductions in DM8O associated with decreasing US anthropogenic emissions. lIncreases in PM2.5 levels between 4 and 10 mu g m(-3) in the Northeast, Southeast, Midwest and South regions are mostly a result of increase in primary anthropogenic particulate matter (PM), enhanced biogenic emissions and land use changes. Changes in boundary conditions shift the composition but do not alter overall simulated PM2.5 mass concentrations.
C1 [Gonzalez-Abraham, R.; Chung, S. H.; Avise, J.; Lamb, B.] Washington State Univ, Pullman, WA 99164 USA.
[Avise, J.] Calif Air Resources Board, Sacramento, CA USA.
[Salathe, E. P., Jr.] Univ Washington Bothell, Bothell, WA USA.
[Nolte, C. G.; Loughlin, D.] US EPA, Res Triangle Pk, NC 27711 USA.
[Guenther, A.; Wiedinmyer, C.; Duhl, T.; Zhang, Y.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Streets, D. G.] Argonne Natl Lab, Argonne, IL 60439 USA.
RP Gonzalez-Abraham, R (reprint author), Portland State Univ, Portland, OR 97207 USA.
EM arodrigo@pdx.edu
RI Nolte, Christopher/H-4345-2012
OI Nolte, Christopher/0000-0001-5224-9965
FU US Environmental Protection Agency Science To Achieve Results grants [RD
83336901-0, 838309621-0]
FX This work was supported by the US Environmental Protection Agency
Science To Achieve Results grants RD 83336901-0 and 838309621-0. This
paper has been cleared by the EPA's administrative review process and
approved for publication. The views expressed in this paper are those of
the authors and do not necessarily reflect the views or policies of the
US Environmental Protection Agency.
NR 99
TC 4
Z9 4
U1 5
U2 19
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 21
BP 12645
EP 12665
DI 10.5194/acp-15-12645-2015
PG 21
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CW9OV
UT WOS:000365329000028
ER
PT S
AU Postigo, C
Jeong, CH
Richardson, SD
Wagner, ED
Plewa, MJ
Simmons, JE
Barcelo, D
AF Postigo, Cristina
Jeong, Clara H.
Richardson, Susan D.
Wagner, Elizabeth D.
Plewa, Michael J.
Simmons, Jane Ellen
Barcelo, Damia
BE Karanfil, T
Mitch, B
Westerhoff, P
Xie, Y
TI Analysis, Occurrence, and Toxicity of Haloacetaldehydes in Drinking
Waters: Iodoacetaldehyde as an Emerging Disinfection By-Product
SO RECENT ADVANCES IN DISINFECTION BY-PRODUCTS
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Occurrence, Formation, Health Effects and Control of
Disinfection By-Products in Drinking Water / 248th ACS National Meeting
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc, Div Environm Chem, Water Res Fdn
DE disinfection by-products; genotoxicity; cytotoxicity; occurrence;
drinking waters; halogenated aldehydes; chloral hydrate; mammalian cells
ID NATURAL ORGANIC-MATTER; HAMSTER OVARY CELLS; SWIMMING POOL WATER;
CHLORINE DIOXIDE; HALOGENATED ACETALDEHYDES; ASPERGILLUS-NIDULANS;
TREATED WATER; COMET ASSAY; CHLORAMINATION; REMOVAL
AB Chlorinated and brominated haloacetaldehydes (HALs) are considered the 3rd largest class of disinfection by-products (DBPs) by weight. The iodinated HAL, iodoacetaldehyde, has been recently reported as an emerging DBP in finished drinking waters. Overall, iodinated DBPs, e.g., iodoacetic acids, iodoacetamides, and iodonitriles, are among the most genotoxic of all DBPs identified. In this context, this chapter reviews the analytical methods available to date to determine HALs in water, and the concentrations at which they are present in finished drinking waters. Since systematic toxicological effects have been only investigated for selected chloro- and bromo- HALs, a comparative study of the genotoxicity and cytotoxicity of this DBP class to mammalian cells is also presented.
C1 [Postigo, Cristina; Barcelo, Damia] IDAEA CSIC, Inst Environm Assessment & WaterRes, Dept Environm Chem, Barcelona 08034, Spain.
[Jeong, Clara H.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA.
[Jeong, Clara H.; Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Safe Global Water Inst, Ctr Adv Mat Purificat Water Syst, Urbana, IL 61801 USA.
[Richardson, Susan D.] Univ S Carolina, JM Palms Ctr GSR, Dept Chem & Biochem, Columbia, SC 29208 USA.
[Simmons, Jane Ellen] US EPA, NHEERL, Res Triangle Pk, NC 27709 USA.
[Barcelo, Damia] Univ Girona, Catalan Inst Water Res ICRA, Girona 17003, Spain.
RP Postigo, C (reprint author), IDAEA CSIC, Inst Environm Assessment & WaterRes, Dept Environm Chem, Carrer Jordi Girona 18-26, Barcelona 08034, Spain.
EM cprqam@cid.csic.es
RI Postigo, Cristina/H-7876-2015
OI Postigo, Cristina/0000-0002-7344-7044
NR 68
TC 0
Z9 0
U1 9
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-3076-7
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2015
VL 1190
BP 25
EP 43
PG 19
WC Engineering, Environmental; Environmental Sciences; Toxicology; Water
Resources
SC Engineering; Environmental Sciences & Ecology; Toxicology; Water
Resources
GA BD9TH
UT WOS:000365248800002
ER
PT J
AU Schreinemachers, DM
Ghio, AJ
Sobus, JR
Williams, MA
AF Schreinemachers, Dina M.
Ghio, Andrew J.
Sobus, Jon R.
Williams, Marc A.
TI Perchlorate Exposure is Associated with Oxidative Stress and Indicators
of Serum Iron Homeostasis Among NHANES 2005-2008 Subjects
SO BIOMARKER INSIGHTS
LA English
DT Article
DE perchlorate; epidemiology; biomarkers; iron homeostasis
ID THYROID-HORMONE LEVELS; URIC-ACID; DEFICIENCY; METABOLISM; FERRITIN;
HEALTH; HYPOTHYROIDISM; TECHNOLOGIES; INFLAMMATION; REMOVAL
AB Perchlorate (ClO4?), an oxidizing agent, is a ubiquitous environmental pollutant. Several studies have investigated its thyroid hormone disrupting properties. Its associations with other biological measures are largely unknown. This study, combining 20052008 National Health and Nutrition Examination Surveys, investigated associations between urinary perchlorate and biomarkers of iron homeostasis, lipids, blood cell counts, and glucose metabolism. Healthy males (n = 3705), non-pregnant females (n = 2967), and pregnant females (n = 356), aged 1259 years, were included in the linear regression models, which showed significant positive (+) and negative (-) associations for both males and non-pregnant females with serum uric acid (-), serum iron (-), RBC count (-), blood urea nitrogen (+), and lymphocyte count (+). Other significant associations were observed for either males or non-pregnant females. Among pregnant females, perchlorate was significantly associated with blood urea nitrogen (+) and serum iron (-). These associations may be indicators of perchlorate's potential effect on several biological systems, which when considered in total, may implicate perturbation of iron homeostasis.
C1 [Schreinemachers, Dina M.; Ghio, Andrew J.; Williams, Marc A.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, ORD, Durham, NC 27709 USA.
[Sobus, Jon R.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, ORD, Durham, NC USA.
RP Schreinemachers, DM (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, ORD, Durham, NC 27709 USA.
EM schreinemachers.dina@epa.gov
NR 45
TC 4
Z9 4
U1 0
U2 1
PU LIBERTAS ACAD
PI AUCKLAND
PA PO BOX 300-874, ALBANY 0752, AUCKLAND, 00000, NEW ZEALAND
SN 1177-2719
J9 BIOMARK INSIGHTS
JI Biomark. Insights
PY 2015
VL 10
BP 9
EP 19
DI 10.4137/BMI.320089
PG 11
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CW6LW
UT WOS:000365110000001
PM 25673971
ER
PT J
AU Sharma, VK
Filip, J
Zboril, R
Varma, RS
AF Sharma, Virender K.
Filip, Jan
Zboril, Radek
Varma, Rajender S.
TI Natural inorganic nanoparticles - formation, fate, and toxicity in the
environment
SO CHEMICAL SOCIETY REVIEWS
LA English
DT Review
ID DISSOLVED ORGANIC-MATTER; SILVER NANOPARTICLES; ANTIBACTERIAL ACTIVITY;
GOLD NANOPARTICLES; ENGINEERED NANOPARTICLES; SURFACE-CHARGE; STABILITY;
REDUCTION; TRANSFORMATION; SYSTEMS
AB The synthesis, stability, and toxicity of engineered metal nanoparticles (ENPs) have been extensively studied during the past two decades. In contrast, research on the formation, fate, and ecological effects of naturally-occurring nanoparticles (NNPs) has become a focus of attention only recently. The natural existence of metal nanoparticles and their oxides/sulfides in waters, wastewaters, ore deposits, mining regions, and hydrothermal vents, as exemplified by the formation of nanoparticles containing silver and gold (AgNPs and AuNPs), Fe, Mn, pyrite (FeS2), Ag2S, CuS, CdS, and ZnS, is dictated largely by environmental conditions (temperature, pH, oxic/anoxic, light, and concentration and characteristics of natural organic matter (NOM)). Examples include the formation of nanoparticles containing pyrite, Cu and Zn-containing pyrite, and iron in hydrothermal vent black smoker emissions. Metal sulfide nanoparticles can be formed directly from their precursor ions or indirectly by sulfide ion-assisted transformation of the corresponding metal oxides under anaerobic conditions. This tutorial focuses on the formation mechanisms, fate, and toxicity of natural metal nanoparticles. Natural waters containing Ag(I) and Au(III) ions in the presence of NOM generate AgNPs and AuNPs under thermal, non-thermal, and photochemical conditions. These processes are significantly accelerated by existing redox species of iron (Fe(II)/Fe(III)). NOM, metal-NOM complexes, and reactive oxygen species (ROS) such as O-2(center dot-), (OH)-O-center dot, and H2O2 are largely responsible for the natural occurrence of nanoparticles. AgNPs and AuNPs emanating from Ag(I)/Au(III)-NOM reactions are stable for several months, thus indicating their potential to be transported over long distances from their point of origin. However, endogenous cations present in natural waters can destabilize the nanoparticles, with divalent cations (e.g., Ca2+, Mg2+) being more influential than their monovalent equivalents (e.g., Na+, K+). The toxicity of NNPs may differ from that of ENPs because of differences in the coatings on the nanoparticle surfaces. An example of this phenomenon is presented and is briefly discussed.
C1 [Sharma, Virender K.] Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, College Stn, TX 77843 USA.
[Filip, Jan; Zboril, Radek; Varma, Rajender S.] Palacky Univ, Reg Ctr Adv Technol & Mat, Dept Expt Phys, Olomouc 77146, Czech Republic.
[Filip, Jan; Zboril, Radek; Varma, Rajender S.] Palacky Univ, Dept Phys Chem, Fac Sci, Olomouc 77146, Czech Republic.
[Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Sharma, VK (reprint author), Texas A&M Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, College Stn, TX 77843 USA.
EM vsharma@sph.tamhsc.edu; Varma.Rajender@epa.gov
RI Zboril, Radek/F-5153-2015;
OI Sharma, Virender/0000-0002-5980-8675; Zboril, Radek/0000-0002-3147-2196
FU Ministry of Education, Youth and Sports of the Czech Republic [LO1305];
Technology Agency of the Czech Republic "Competence Centers''
[TE01020218]
FX V.K. Sharma, J. Filip, and R. Zboril acknowledge the support by the
Ministry of Education, Youth and Sports of the Czech Republic (project
LO1305) and Technology Agency of the Czech Republic "Competence
Centers'' (project No. TE01020218). We thank Dr. Leslie Cizmas and Dr.
John Leazer for their comments to improve the article.
NR 53
TC 20
Z9 20
U1 42
U2 191
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 0306-0012
EI 1460-4744
J9 CHEM SOC REV
JI Chem. Soc. Rev.
PY 2015
VL 44
IS 23
BP 8410
EP 8423
DI 10.1039/c5cs00236b
PG 14
WC Chemistry, Multidisciplinary
SC Chemistry
GA CW2WI
UT WOS:000364853400003
PM 26435358
ER
PT J
AU Nolte, CG
Appel, KW
Kelly, JT
Bhave, PV
Fahey, KM
Collett, JL
Zhang, L
Young, JO
AF Nolte, C. G.
Appel, K. W.
Kelly, J. T.
Bhave, P. V.
Fahey, K. M.
Collett, J. L., Jr.
Zhang, L.
Young, J. O.
TI Evaluation of the Community Multiscale Air Quality (CMAQ) model v5.0
against size-resolved measurements of inorganic particle composition
across sites in North America
SO Geoscientific Model Development
LA English
DT Article
ID ATMOSPHERIC BOUNDARY-LAYER; FINE PARTICULATE MATTER; NONLOCAL
CLOSURE-MODEL; UNITED-STATES; SEA-SALT; PERFORMANCE EVALUATION; RURAL
LOCATIONS; AEROSOL; IMPACT; SYSTEM
AB This work evaluates particle size-composition distributions simulated by the Community Multiscale Air Quality (CMAQ) model using micro-orifice uniform deposit impactor (MOUDI) measurements at 18 sites across North America. Size-resolved measurements of particulate SO42-, NO3-, NH4+, Na+, Cl-, Mg2+, Ca2+, and K+ are compared to CMAQ model output for discrete sampling periods between 2002 and 2005. The observation sites were predominantly in remote areas (e.g., National Parks) in the USA and Canada, and measurements were typically made for a period of roughly 1 month. For SO42- and NH4+, model performance was consistent across the USA and Canadian sites, with the model slightly overestimating the peak particle diameter and underestimating the peak particle concentration compared to the observations. Na+ and Mg2+ size distributions were generally well represented at coastal sites, indicating reasonable simulation of emissions from sea spray. CMAQ is able to simulate the displacement of Cl- in aged sea spray aerosol, though the extent of Cl- depletion relative to Na+ is often underpredicted. The model performance for NO3- exhibited much more site-to-site variability than that of SO42- and NH4+, with the model ranging from an underestimation to overestimation of both the peak diameter and peak particle concentration across the sites. Computing PM2.5 from the modeled size distribution parameters rather than by summing the masses in the Aitken and accumulation modes resulted in differences in daily averages of up to 1 mu gm(-3) (10 %), while the difference in seasonal and annual model performance compared to observations from the Interagency Monitoring of Protected Visual Environments (IMPROVE), Chemical Speciation Network (CSN), and Air Quality System (AQS) networks was very small. Two updates to the CMAQ aerosol model - changes to the assumed size and mode width of emitted particles and the implementation of gravitational settling - resulted in small improvements in modeled size distributions.
C1 [Nolte, C. G.; Appel, K. W.; Fahey, K. M.; Young, J. O.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Kelly, J. T.] US EPA, Off Air Qual Planning & Stand, Air Qual Assessment Div, Res Triangle Pk, NC 27711 USA.
[Bhave, P. V.] Int Ctr Integrated Mt Dev, Khumaltar, Lalitpur, Nepal.
[Collett, J. L., Jr.] Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA.
[Zhang, L.] Environm Canada, Sci & Technol Branch, Air Qual Res Div, Toronto, ON, Canada.
RP Nolte, CG (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
EM nolte.chris@epa.gov
RI Nolte, Christopher/H-4345-2012; Kelly, James/F-8135-2010; Collett,
Jeffrey/F-2862-2010
OI Nolte, Christopher/0000-0001-5224-9965; Kelly,
James/0000-0001-6574-5714; Collett, Jeffrey/0000-0001-9180-508X
FU United States Environmental Protection Agency through its Office of
Research and Development
FX We thank Taehyoung Lee (Colorado State University), Noreen Poor
(University of South Florida), and Charles Stanier (University of Iowa)
for providing MOUDI measurements that helped make this analysis
possible. Brett Gantt and Rohit Mathur (US EPA) provided constructive
comments in reviewing this manuscript. We thank Heather Simon and George
Pouliot (US EPA) for their assistance with PM profiles in the SPECIATE
database. The United States Environmental Protection Agency through its
Office of Research and Development supported the research described
here. It has been subjected to Agency review and approved for
publication. The views and interpretations in this publication are those
of the authors and are not necessarily attributable to their
organizations.
NR 57
TC 7
Z9 7
U1 2
U2 16
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 9
BP 2877
EP 2892
DI 10.5194/gmd-8-2877-2015
PG 16
WC Geosciences, Multidisciplinary
SC Geology
GA CV5QJ
UT WOS:000364325700010
ER
PT S
AU Lau, C
AF Lau, Christopher
BE DeWitt, JC
TI Perfluorinated Compounds: An Overview
SO TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
DE Perfluoroalkyl acids; Toxicology; Health effects; Epidemiology; Overview
ID PERFLUOROOCTANE SULFONATE PFOS; PERFLUOROALKYL ACIDS PFAAS; GLOBAL
EMISSION INVENTORIES; ACTIVATED RECEPTOR-ALPHA; 2 GERMAN CITIES;
TEMPORAL TRENDS; HUMAN EXPOSURE; FRESH-WATER; POLYFLUOROALKYL
SUBSTANCES; PHOSPHONIC-ACIDS
AB This chapter provides an overarching introduction to the subject matter of this volume: toxicology and health effects of perfluorinated compounds (PFCs). It highlights briefly the unique chemical and physical properties of these chemicals, their production history and commercial uses, and their environmental and health concerns. The distribution profiles of these persistent contaminants in environmental media, wildlife and humans, as well as potential pathways of human exposure are characterized. General toxicological features of these chemicals include major species and sex differences in pharmacokinetic disposition among congeners with different carbon-chain lengths and functional groups, and differential potencies based on their primary mechanism of action, i.e., activation of the nuclear receptor PPARoc. Current understanding of adverse effects associated with PFC exposure based on laboratory animal models include hepatotoxicity, tumor induction, developmental toxicity, immunotoxicity, neurotoxicity and endocrine disruption. Associations and probable links between exposure to some PFCs and adverse health outcomes in humans have been suggested by recent epidemiological reports. Ecological and human health risk assessments of these chemicals are still in their infancy. Each of these sub-topics will be expanded into full discussion in subsequent chapters. Importantly, a new generation of fluorinated chemicals has already emerged in commerce, with little information regarding their environmental fate and distribution as well as potential health effects. Materials presented in this volume should provide a scientific basis to inform the design of safe replacement products for the current crop of perfluorinated chemicals that promises to be less persistent and prevalent in the environment.
C1 US EPA, Dev Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
RP Lau, C (reprint author), US EPA, Dev Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Mail Drop B105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM lau.christopher@epa.gov
NR 175
TC 5
Z9 5
U1 4
U2 15
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-3-319-15518-0; 978-3-319-15517-3
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 1
EP 21
DI 10.1007/978-3-319-15518-0_1
D2 10.1007/978-3-319-15518-0
PG 21
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD9KE
UT WOS:000364811700002
ER
PT S
AU Abbott, BD
AF Abbott, Barbara D.
BE DeWitt, JC
TI Developmental Toxicity
SO TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
DE Developmental toxicity; Teratology; Peroxisome proliferator activated
receptor (PPAR); Postnatal toxicity
ID PROLIFERATOR-ACTIVATED RECEPTORS; AMMONIUM PERFLUOROOCTANOATE APFO;
RESTRICTED GESTATIONAL EXPOSURES; ORGANIC ANION TRANSPORTERS;
MAMMARY-GLAND DEVELOPMENT; SPRAGUE-DAWLEY RATS; ALPHA PPAR-ALPHA;
PERFLUOROALKYL ACIDS; CROSS-FOSTER; PERFLUORINATED COMPOUNDS
AB This chapter provides an overview of the developmental toxicity resulting from exposure to perfluorinated alkyl acids (PFAAs). The majority of studies of PFAA-induced developmental toxicity have examined effects of perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA) and there is only limited information available for other members of this family of chemicals. In this chapter, there are separate overviews of the developmental toxicity of PFOS and PFOA, along with a summary of studies available for perfluorobutyrate (PFBA), perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). In general, among the PFAAs that do produce developmental toxicity in one or more laboratory species, prenatal PFAA exposure in teratology studies typically does not result in major malformations and significant findings are often limited to the higher exposure levels. The postnatal effects in rats or mice exposed to PFAAs are typically increased mortality in the first hours or week after birth, effects on weight which may persist beyond weaning, delayed eye opening, abnormal mammary gland development, and liver hypertrophy. The role of peroxisome proliferator activated receptor-alpha (PPARoc) in mediating developmental effects is discussed, including insights from genetically modified mice, PPARoc knockout mice, and mice expressing the human PPARoc gene. Pharmacokinetic issues are relevant to selecting an appropriate animal model for developmental studies and regarding the influence of rapid clearance on manifestation of developmental toxicity. Whether or not a particular PFAA will cause developmental toxicity depends on levels and timing of fetal exposure and is influenced by species and gender specific pharmacokinetic characteristics that impact exposure of the conceptus throughout gestation and during the lactational period. Factors influencing the pharmacokinetics and developmental outcomes include chemical characteristics of a particular PFAA (carbon chain length, functional moiety carboxylate or sulfonate), species specific characteristics (sex and species specific expression of particular transporters in the kidney that influence clearance), timing and level of exposure to the developing fetus, and ability of the PFAA to activate PPARoc (human, mouse, and rat PPAR alpha differ in responses to PFAA, carboxylates are more effective than sulfonates, and longer carbon chain PFAA are more potent than short chain PFAA). The expression and activation of PPAR alpha is necessary for mediating developmental effects of PFOA and PFNA, but the early postnatal deaths caused by exposure to PFOS were not dependent on expression of PPAR alpha.
C1 US EPA, Tox Assessment Div B10504, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Abbott, BD (reprint author), US EPA, Tox Assessment Div B10504, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Abbott.barbara@epa.gov
NR 56
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-3-319-15518-0; 978-3-319-15517-3
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 203
EP 218
DI 10.1007/978-3-319-15518-0_8
D2 10.1007/978-3-319-15518-0
PG 16
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD9KE
UT WOS:000364811700009
ER
PT S
AU Wambaugh, J
AF Wambaugh, John
BE DeWitt, JC
TI Dosimetric Anchoring of Toxicological Studies
SO TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES
SE Molecular and Integrative Toxicology
LA English
DT Article; Book Chapter
DE Pharmacokinetics; Dosimetric anchor; Mathematical models; Extrapolation;
Dose regimen; Biological variability
ID AMMONIUM PERFLUOROOCTANOATE APFO; ORGANIC ANION TRANSPORTERS;
THYROID-HORMONE STATUS; POTASSIUM PERFLUOROOCTANESULFONATE; COMPARATIVE
PHARMACOKINETICS; CYNOMOLGUS MONKEYS; 2-GENERATION REPRODUCTION;
DEVELOPMENTAL TOXICITY; LACTATIONAL EXPOSURE; PERFLUOROALKYL ACIDS
AB Comparing the onset of effects between different toxicological studies is often confounded by pharmacokinetics (PK). Differences between studies can be biological in origin (e.g. species, gender) as well as due to dose regimen (e.g. spacing, magnitude, duration, and route of administration). However, if the pharmacodynamic mechanism underlying the observed toxicological effect is conserved, and some measure of the tissue concentration (i.e., dos imetry) at the site of effect can be determined, then it is expected that this dosimetric anchor should also be conserved across studies. Careful consideration of the PK is required, and mathematical models for PK can address this need. It is relatively easy to extrapolate model predictions if there is a reasonable expectation of linear behavior and conserved PK between test conditions and those to be predicted. For perfluorinated compounds (PFCs), however, we expect PK extrapolation to be much more difficult. Aspects of the distribution, metabolism, and elimination of PFCs have unusual and non-linear features that must be considered. The PK of PFCs is especially unusual in that the half-lives of the longer chain PFCs vary by many orders of magnitude across species, dose regimen, and in some cases, across gender. The empirical saturable renal resorption hypothesis of the Andersen et al. (Toxicol 227(16978759):156-164, 2006) model provides the simplest available non-linear PK model that describes PFCs PK. However, despite the plausible biological mechanism, this model is still empirical, requiring that species-specific parameters are estimated using species-specific PK data. With this model, diverse toxicological studies of PFCs can be shown to be roughly consistent with respect to the internal, dosimetric anchors induced by their various study designs.
C1 US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Wambaugh, J (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Mail Drop B205-01 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Wambaugh.john@epa.gov
OI Wambaugh, John/0000-0002-4024-534X
NR 93
TC 0
Z9 0
U1 2
U2 3
PU SPRINGER-VERLAG LONDON LTD
PI GODALMING
PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY,
ENGLAND
SN 2168-4219
BN 978-3-319-15518-0; 978-3-319-15517-3
J9 MOLEC INTEGR TOXICOL
PY 2015
BP 337
EP 361
DI 10.1007/978-3-319-15518-0_14
D2 10.1007/978-3-319-15518-0
PG 25
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD9KE
UT WOS:000364811700015
ER
PT J
AU Wang, C
Cyterski, M
Feng, YJ
Gao, P
Sun, QF
AF Wang, Ce
Cyterski, Mike
Feng, Yujie
Gao, Peng
Sun, Qingfang
TI Spatiotemporal characteristics of organic contaminant concentrations and
ecological risk assessment in the Songhua River, China
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; STATISTICAL TECHNIQUES; AQUATIC
ORGANISMS; TRANSPORT MODEL; WATER; POLLUTION; FATE; SEDIMENTS; RESIDUES;
QUANTIFY
AB To control source pollution and improve water quality, an understanding of the spatiotemporal characteristics of organic contaminant concentrations in affected receiving waters is necessary. The Songhua River in northeast China is the country's third-largest domestic river and loadings of organic contaminants along an industrialized section have made it the focal point of a national pollution reduction plan. In addition to water quality issues, management of the Songhua River basin must also address local economic development, aquatic ecosystem sustainability and political relationships with Russia. In three periods spanning 2006 to 2010, eight polycyclic aromatic hydrocarbons (PAHs) and eight phenols were measured in surface waters at ten monitoring sites along the river. A generalized linear model (GLM) was used to characterize water quality at different sites and time periods. Chemical concentrations of the organic compounds showed significant sinusoidal seasonal patterns and the concentrations declined significantly from 2006 to 2010, possibly due to management practices designed to control water pollution. A critical body residue analysis showed that water concentrations measured during the winter of 2007 across all monitoring sites, but especially at S1-Shaokou and S2-Songhuajiangcun, presented a high risk for fish species. The spatiotemporal characteristics of water quality and estimated ecological risks shown here add to the body of knowledge to develop policies on industrial output and pollution management strategies for the Songhua River basin.
C1 [Wang, Ce] Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China.
[Cyterski, Mike] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, New York, NY USA.
[Feng, Yujie; Gao, Peng; Sun, Qingfang] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Peoples R China.
RP Wang, C (reprint author), Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China.
EM wangce@nju.edu.cn; cyterski.mike@epa.gov
RI Wang, Ce/B-2500-2012
OI Wang, Ce/0000-0001-6244-1205
FU Major Science and Technology Program for Water Pollution Control and
Treatment [2012ZX07506-004-004]; Fundamental Research Funds for the
Central Universities [20620140481]; National Scientific Fund for
Distinguished Young Scholars [51125033]; Funds for Creative Research
Group of China [51121062]
FX This research was supported by the Major Science and Technology Program
for Water Pollution Control and Treatment (2012ZX07506-004-004),
Fundamental Research Funds for the Central Universities (20620140481),
National Scientific Fund for Distinguished Young Scholars (51125033) and
Funds for Creative Research Group of China (51121062). We thank Tao
Hong, USEPA, for analytical assistance, Fran Rauschenberg, USEPA, for
insightful editorial suggestions, and Yang Tao, Geomatics Center of
Jiangsu Province of China, for GIS processing.
NR 33
TC 1
Z9 1
U1 3
U2 23
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 11
BP 1967
EP 1975
DI 10.1039/c5em00375j
PG 9
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CV3GK
UT WOS:000364146800011
PM 26442573
ER
PT J
AU He, YT
Su, CM
AF He, Yongtian Thomas
Su, Chunming
BE Shiomi, N
TI Use of Additives in Bioremediation of Contaminated Groundwater and Soil
SO ADVANCES IN BIOREMEDIATION OF WASTEWATER AND POLLUTED SOIL
LA English
DT Article; Book Chapter
DE Organic contaminants; carbon substrates; additives; bioremediation
implementation; potential issues
ID VINYL-CHLORIDE; SUBSURFACE REMEDIATION; TETRACHLOROETHENE;
BIOAUGMENTATION; DETOXIFICATION; DECHLORINATION; HYDROCARBONS;
SURFACTANTS; TOXICITY; KINETICS
AB This chapter reviews the application of additives used in bioremediation of chlorinated solvents and fuels for groundwater and soil remediation. Soluble carbon substrates are applicable to most site conditions except aquifers with very high or very low groundwater flow. Slow-release and solid substrates are intended to be long-lasting in supplying carbon for microbial growth thereby minimizing operation and maintenance requirements. Microbes as special additives can be used to enhance bioremediation (bioaugmentation) where such microbes are lacking. Oxygen gas can be added to increase aerobic biodegradation, and nutrients addition may be needed to stimulate and maintain sufficient microbial population. pH modifiers to control acidity for optimal microbial growth and degradation can also be added. Delivery of additives to the subsurface can he accomplished through permanent injection wells, direct-push methods, or permeable reactive barriers (biowall). Potential issues with additive use include biofouling, stalling, short circuiting, displacement, reduced hydraulic conductivity, and secondary water quality deterioration. Methods and techniques to deal with these issues are provided and future research needs are identified.
C1 [He, Yongtian Thomas] W Virginia Univ, West Virginia Water Res Inst, Morgantown, WV 26506 USA.
[Su, Chunming] US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
RP Su, CM (reprint author), US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
EM Su.Chunming@epa.gov
NR 42
TC 0
Z9 0
U1 3
U2 6
PU INTECH EUROPE
PI RIJEKA
PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA
BN 978-953-51-2165-7
PY 2015
BP 145
EP 164
DI 10.5772/60915
D2 10.5772/59328
PG 20
WC Biotechnology & Applied Microbiology; Engineering, Environmental; Water
Resources
SC Biotechnology & Applied Microbiology; Engineering; Water Resources
GA BD7XR
UT WOS:000363679000008
ER
PT J
AU Verma, S
Baig, RBN
Han, C
Nadagouda, MN
Varma, RS
AF Verma, Sanny
Baig, R. B. Nasir
Han, Changseok
Nadagouda, Mallikarjuna N.
Varma, Rajender S.
TI Magnetic graphitic carbon nitride: its application in the C-H activation
of amines
SO CHEMICAL COMMUNICATIONS
LA English
DT Article
ID CATALYZED OXIDATIVE CYANATION; TERTIARY-AMINES; SODIUM-CYANIDE;
SUSTAINABLE APPLICATIONS; HYDROGEN-PEROXIDE; BOND ACTIVATION; GREEN
CHEMISTRY; 3-AROYLINDOLES; FUTURE
AB Magnetic graphitic carbon nitride, Fe@g-C3N4, has been synthesized by adorning a graphitic carbon nitride (g-C3N4) support with iron oxide via non-covalent interaction. The magnetically recyclable catalyst showed excellent reactivity for the expeditious C-H activation and cyanation of amines.
C1 [Verma, Sanny; Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Han, Changseok; Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@epa.gov
FU U.S. Department of Energy; U.S. Environmental Protection Agency
FX SV and RBNB were supported by the Postgraduate Research Program at the
National Risk Management Research Laboratory administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 34
TC 20
Z9 20
U1 12
U2 48
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1359-7345
EI 1364-548X
J9 CHEM COMMUN
JI Chem. Commun.
PY 2015
VL 51
IS 85
BP 15554
EP 15557
DI 10.1039/c5cc05895c
PG 4
WC Chemistry, Multidisciplinary
SC Chemistry
GA CT9WS
UT WOS:000363167900018
PM 26352198
ER
PT J
AU Gawande, MB
Goswami, A
Asefa, T
Guo, HZ
Biradar, AV
Peng, DL
Zboril, R
Varma, RS
AF Gawande, Manoj B.
Goswami, Anandarup
Asefa, Tewodros
Guo, Huizhang
Biradar, Ankush V.
Peng, Dong-Liang
Zboril, Radek
Varma, Rajender S.
TI Core-shell nanoparticles: synthesis and applications in catalysis and
electrocatalysis
SO CHEMICAL SOCIETY REVIEWS
LA English
DT Review
ID OXYGEN REDUCTION REACTION; CROSS-COUPLING REACTIONS; LITHIUM-ION
BATTERIES; ONE-POT SYNTHESIS; CORE/SHELL HIERARCHICAL NANOSTRUCTURES;
ASYMMETRIC TRANSFER HYDROGENATION; ENHANCED PHOTOCATALYTIC ACTIVITY;
STRUCTURED MESOPOROUS SILICA; SURFACE ELECTRONIC-STRUCTURE; METAL-FREE
ELECTROCATALYSTS
AB Core-shell nanoparticles (CSNs) are a class of nanostructured materials that have recently received increased attention owing to their interesting properties and broad range of applications in catalysis, biology, materials chemistry and sensors. By rationally tuning the cores as well as the shells of such materials, a range of core-shell nanoparticles can be produced with tailorable properties that can play important roles in various catalytic processes and offer sustainable solutions to current energy problems. Various synthetic methods for preparing different classes of CSNs, including the Stober method, solvothermal method, one-pot synthetic method involving surfactants, etc., are briefly mentioned here. The roles of various classes of CSNs are exemplified for both catalytic and electrocatalytic applications, including oxidation, reduction, coupling reactions, etc.
C1 [Gawande, Manoj B.; Goswami, Anandarup; Zboril, Radek] Palacky Univ, Dept Phys Chem, Fac Sci, Reg Ctr Adv Technol & Mat, Olomouc 78371, Czech Republic.
[Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA.
[Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA.
[Guo, Huizhang; Peng, Dong-Liang] Xiamen Univ, Coll Mat, Dept Mat Sci & Engn, Xiamen 361005, Peoples R China.
[Biradar, Ankush V.] CSIR Natl Chem Lab, Catalysis Div, Pune 411008, Maharashtra, India.
[Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Gawande, MB (reprint author), Palacky Univ, Dept Phys Chem, Fac Sci, Reg Ctr Adv Technol & Mat, Slechtitelu 11, Olomouc 78371, Czech Republic.
EM manoj.gawande@upol.cz; radek.zboril@upol.cz;
Varma.Rajender@epamail.epa.gov
RI Peng, DL/G-4096-2010; Zboril, Radek/F-5153-2015;
OI Zboril, Radek/0000-0002-3147-2196
FU Operational Program Education for Competitiveness - European Social Fund
of the Ministry of Education, Youth and Sports of the Czech Republic
[CZ.1.07/2.3.00/30.0041]; National Science Foundation in the USA
[1508611, 1134289]; [LO1305]
FX The authors gratefully acknowledge support from the project LO1305 and
the Operational Program Education for Competitiveness - European Social
Fund (project CZ.1.07/2.3.00/30.0041) of the Ministry of Education,
Youth and Sports of the Czech Republic. TA gratefully acknowledges
financial support from the National Science Foundation in the USA (Grant
Nos. 1508611 and 1134289) for his group's work on core-shell
nanocatalysis.
NR 460
TC 72
Z9 72
U1 88
U2 293
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 0306-0012
EI 1460-4744
J9 CHEM SOC REV
JI Chem. Soc. Rev.
PY 2015
VL 44
IS 21
BP 7540
EP 7590
DI 10.1039/c5cs00343a
PG 51
WC Chemistry, Multidisciplinary
SC Chemistry
GA CT9QX
UT WOS:000363152800005
PM 26288197
ER
PT B
AU Dutrow, E
AF Dutrow, Elizabeth
BE Rossiter, AP
Jones, BP
TI PROTECTING THE ENVIRONMENT AND INFLUENCING ENERGY PERFORMANCE WITHIN
PROCESS INDUSTRIES
SO ENERGY MANAGEMENT AND EFFICIENCY FOR THE PROCESS INDUSTRIES
LA English
DT Article; Book Chapter
C1 US EPA, ENERGY STAR Ind Sect Partnerships, Washington, DC 20460 USA.
RP Dutrow, E (reprint author), US EPA, ENERGY STAR Ind Sect Partnerships, Washington, DC 20460 USA.
NR 11
TC 0
Z9 0
U1 0
U2 0
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-119-03322-6; 978-1-118-83825-9
PY 2015
BP 81
EP 92
D2 10.1002/9781119033226
PG 12
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA BD5OS
UT WOS:000361678300009
ER
PT J
AU Trisciuzzi, D
Alberga, D
Mansouri, K
Judson, R
Cellamare, S
Catto, M
Carotti, A
Benfenati, E
Novellino, E
Mangiatordi, GF
Nicolotti, O
AF Trisciuzzi, Daniela
Alberga, Domenico
Mansouri, Kamel
Judson, Richard
Cellamare, Saverio
Catto, Marco
Carotti, Angelo
Benfenati, Emilio
Novellino, Ettore
Mangiatordi, Giuseppe Felice
Nicolotti, Orazio
TI Docking-based classification models for exploratory toxicology studies
on high-quality estrogenic experimental data
SO FUTURE MEDICINAL CHEMISTRY
LA English
DT Article
ID ENDOCRINE-DISRUPTING CHEMICALS; LIGAND-BINDING DOMAIN; RECEPTOR-ALPHA;
COMPUTATIONAL TOXICOLOGY; DRUG DISCOVERY; BREAST-CANCER; QSAR; BETA;
TOOLS; RISK
AB Background: The ethical and practical limitation of animal testing has recently promoted computational methods for the fast screening of huge collections of chemicals. Results: The authors derived 24 reliable docking-based classification models able to predict the estrogenic potential of a large collection of chemicals provided by the US Environmental Protection Agency. Model performances were challenged by considering AUC, EF1% (EFmax = 7.1), -LR (at sensitivity = 0.75); +LR (at sensitivity = 0.25) and 37 reference compounds comprised within the training set. Moreover, external predictions were made successfully on ten representative known estrogenic chemicals and on a set consisting of >32,000 chemicals. Conclusion: The authors demonstrate that structure-based methods, widely applied to drug discovery programs, can be fairly adapted to exploratory toxicology studies.
C1 [Trisciuzzi, Daniela; Cellamare, Saverio; Catto, Marco; Carotti, Angelo; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio] Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, I-70126 Bari, Italy.
[Alberga, Domenico] Univ Bari Aldo Moro, Dipartimento Interateneo Fis M Merlin, Ist Nazl Fis Nucl, I-70126 Bari, Italy.
[Mansouri, Kamel; Judson, Richard] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Benfenati, Emilio] IRCCS, Ist Ric Farmacol Mario Negri, I-20156 Milan, Italy.
[Novellino, Ettore] Univ Naples Federico II, Dipartimento Farm, I-80138 Naples, Italy.
RP Mangiatordi, GF (reprint author), Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70126 Bari, Italy.
EM giuseppe.mangiatordi@uniba.it; orazio.nicolotti@uniba.it
OI CATTO, Marco/0000-0002-8411-304X; Cellamare,
Saverio/0000-0003-3765-7842; Mansouri, Kamel/0000-0002-6426-8036
FU FIRB (Futuro in Ricerca) [RBFR12SJA8_003]; IDEA [GRBA11E-B3G]; LIFE+
project EDESIA
FX O Nicolotti and GF Mangiatordi wish to acknowledge FIRB (Futuro in
Ricerca 2012, RBFR12SJA8_003) and IDEA 2011 (GRBA11E-B3G). E Benfenati
would like to thank LIFE+ project EDESIA for funding. The authors have
no other relevant affiliations or financial involvement with any
organization or entity with a financial interest in or financial
conflict with the subject matter or materials discussed in the
manuscript apart from those disclosed.
NR 53
TC 3
Z9 3
U1 0
U2 3
PU FUTURE SCI LTD
PI LONDON
PA UNITED HOUSE, 2 ALBERT PL, LONDON, N3 1QB, ENGLAND
SN 1756-8919
EI 1756-8927
J9 FUTURE MED CHEM
JI Future Med. Chem.
PY 2015
VL 7
IS 14
BP 1921
EP 1936
DI 10.4155/fmc.15.103
PG 16
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CU1BB
UT WOS:000363252900011
PM 26440057
ER
PT B
AU Wilkin, RT
Lee, TR
McNeil, MS
Su, CM
Adair, C
AF Wilkin, Richard T.
Lee, Tony R.
McNeil, Mary Sue
Su, Chunming
Adair, Cherri
BE Naidu, R
Birke, V
TI Fourteen-Year Assessment of a Permeable Reactive Barrier for Treatment
of Hexavalent Chromium and Trichloroethylene
SO PERMEABLE REACTIVE BARRIER: SUSTAINABLE GROUNDWATER REMEDIATION
SE Advances in Trace Elements in the Environment
LA English
DT Article; Book Chapter
ID PERFORMANCE; IRON
C1 [Wilkin, Richard T.; McNeil, Mary Sue; Su, Chunming; Adair, Cherri] US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
[Lee, Tony R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK USA.
RP Wilkin, RT (reprint author), US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-2448-1; 978-1-4822-2447-4
J9 ADV TRACE ELEM ENVIR
PY 2015
BP 99
EP 107
PG 9
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BD7FH
UT WOS:000362980800007
ER
PT B
AU Ludwig, RD
Wilkin, RT
Acree, SD
Ross, RR
Lee, TR
AF Ludwig, Ralph D.
Wilkin, Richard T.
Acree, Steven D.
Ross, Randall R.
Lee, Tony R.
BE Naidu, R
Birke, V
TI Organic-Based Permeable Reactive Barriers for the Treatment of Heavy
Metals, Arsenic, and Acidity
SO PERMEABLE REACTIVE BARRIER: SUSTAINABLE GROUNDWATER REMEDIATION
SE Advances in Trace Elements in the Environment
LA English
DT Article; Book Chapter
ID SLUG TEST
C1 [Ludwig, Ralph D.; Acree, Steven D.; Ross, Randall R.; Lee, Tony R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
[Wilkin, Richard T.] US EPA, Natl Risk Management Res Lab, Ada, OK USA.
RP Ludwig, RD (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
NR 8
TC 0
Z9 0
U1 1
U2 1
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-2448-1; 978-1-4822-2447-4
J9 ADV TRACE ELEM ENVIR
PY 2015
BP 135
EP 149
PG 15
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BD7FH
UT WOS:000362980800009
ER
PT J
AU Janssens-Maenhout, G
Crippa, M
Guizzardi, D
Dentener, F
Muntean, M
Pouliot, G
Keating, T
Zhang, Q
Kurokawa, J
Wankmuller, R
van der Gon, HD
Kuenen, JJP
Klimont, Z
Frost, G
Darras, S
Koffi, B
Li, M
AF Janssens-Maenhout, G.
Crippa, M.
Guizzardi, D.
Dentener, F.
Muntean, M.
Pouliot, G.
Keating, T.
Zhang, Q.
Kurokawa, J.
Wankmueller, R.
van der Gon, H. Denier
Kuenen, J. J. P.
Klimont, Z.
Frost, G.
Darras, S.
Koffi, B.
Li, M.
TI HTAP_v2.2: a mosaic of regional and global emission grid maps for 2008
and 2010 to study hemispheric transport of air pollution
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID TRENDS; METHODOLOGY; DIOXIDE; GASES; ASIA
AB The mandate of the Task Force Hemispheric Transport of Air Pollution (TF HTAP) under the Convention on Long-Range Transboundary Air Pollution (CLRTAP) is to improve the scientific understanding of the intercontinental air pollution transport, to quantify impacts on human health, vegetation and climate, to identify emission mitigation options across the regions of the Northern Hemisphere, and to guide future policies on these aspects.
The harmonization and improvement of regional emission inventories is imperative to obtain consolidated estimates on the formation of global-scale air pollution. An emissions data set has been constructed using regional emission grid maps (annual and monthly) for SO2, NOx, CO, NMVOC, NH3, PM10, PM2.5, BC and OC for the years 2008 and 2010, with the purpose of providing consistent information to global and regional scale modelling efforts.
This compilation of different regional gridded inventories - including that of the Environmental Protection Agency (EPA) for USA, the EPA and Environment Canada (for Canada), the European Monitoring and Evaluation Programme (EMEP) and Netherlands Organisation for Applied Scientific Research (TNO) for Europe, and the Model Intercomparison Study for Asia (MICS-Asia III) for China, India and other Asian countries - was gap-filled with the emission grid maps of the Emissions Database for Global Atmospheric Research (EDGARv4.3) for the rest of the world (mainly South America, Africa, Russia and Oceania). Emissions from seven main categories of human activities (power, industry, residential, agriculture, ground transport, aviation and shipping) were estimated and spatially distributed on a common grid of 0.1 degrees x 0.1 degrees longitude-latitude, to yield monthly, global, sector-specific grid maps for each substance and year.
The HTAP_v2.2 air pollutant grid maps are considered to combine latest available regional information within a complete global data set. The disaggregation by sectors, high spatial and temporal resolution and detailed information on the data sources and references used will provide the user the required transparency. Because HTAP_v2.2 contains primarily official and/or widely used regional emission grid maps, it can be recommended as a global baseline emission inventory, which is regionally accepted as a reference and from which different scenarios assessing emission reduction policies at a global scale could start.
An analysis of country-specific implied emission factors shows a large difference between industrialised countries and developing countries for acidifying gaseous air pollutant emissions (SO2 and NOx) from the energy and industry sectors. This is not observed for the particulate matter emissions (PM10, PM2.5), which show large differences between countries in the residential sector instead. The per capita emissions of all world countries, classified from low to high income, reveal an increase in level and in variation for gaseous acidifying pollutants, but not for aerosols. For aerosols, an opposite trend is apparent with higher per capita emissions of particulate matter for low income countries.
C1 [Janssens-Maenhout, G.; Crippa, M.; Guizzardi, D.; Dentener, F.; Muntean, M.; Koffi, B.] European Commiss, Joint Res Ctr, Inst Environm & Sustainabil, I-21027 Ispra, VA, Italy.
[Pouliot, G.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Keating, T.] US EPA, Off Air & Radiat, Washington, DC 20460 USA.
[Zhang, Q.; Li, M.] Tsinghua Univ, Ctr Earth Syst Sci, Minist Educ, Key Lab Earth Syst Modelling, Beijing 100084, Peoples R China.
[Kurokawa, J.] Asia Ctr Air Pollut Res, Nishi Ku, Niigata, Niigata 9502144, Japan.
[Wankmueller, R.] Fed Environm Agcy, EMEP, Ctr Emiss Inventory & Project, A-1090 Vienna, Austria.
[van der Gon, H. Denier; Kuenen, J. J. P.] TNO, Dept Climate Air & Sustainabil, NL-3584 CB Utrecht, Netherlands.
[Klimont, Z.] Int Inst Appl Syst Anal, A-2361 Laxenburg, Austria.
[Frost, G.] NOAA, Earth Syst Res Lab, Boulder, CO USA.
[Frost, G.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Darras, S.] Observ Midi Pyrenees, CNRS, SEDOO, F-31400 Toulouse, France.
[Li, M.] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Janssens-Maenhout, G.] Univ Ghent, B-9000 Ghent, Belgium.
RP Janssens-Maenhout, G (reprint author), European Commiss, Joint Res Ctr, Inst Environm & Sustainabil, Via Fermi 2749, I-21027 Ispra, VA, Italy.
EM greet.maenhout@jrc.ec.europa.eu
RI Klimont, Zbigniew/P-7641-2015; Zhang, Qiang/D-9034-2012; Frost,
Gregory/I-1958-2013; Manager, CSD Publications/B-2789-2015
OI Klimont, Zbigniew/0000-0003-2630-198X;
FU EC-DG Environment [AA 070402/2007/47597/ MAR/C5, 33075]
FX This research was partially funded by EC-DG Environment under AA
070402/2007/47597/ MAR/C5 and 33075. S. Galmarini (JRC) and A. Zuber (DG
Environment) are thanked for the continuing support to the HTAP project.
The authors would also like to thank all HTAP-modelers providing first
feedback. Colleagues of the ECCAD project, C. Granier, A. Mieville, of
the TNO-MACC project and of EMEP-MSCW are gratefully acknowledged for
help provided during the preparation of this work.
NR 65
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PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 19
BP 11411
EP 11432
DI 10.5194/acp-15-11411-2015
PG 22
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CT7CN
UT WOS:000362971000030
ER
PT J
AU Reichle, LJ
Cook, R
Yanca, CA
Sonntag, DB
AF Reichle, Lawrence J.
Cook, Rich
Yanca, Catherine A.
Sonntag, Darrell B.
TI Development of organic gas exhaust speciation profiles for nonroad
spark-ignition and compression-ignition engines and equipment
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID EMISSIONS; BLENDS
AB The composition of exhaust emissions from nonroad engines and equipment varies based on a number of parameters, including engine type, emission control technology, fuel composition, and operating conditions. Speciated emissions data which characterize the chemical composition of these emissions are needed to develop chemical speciation profiles used for air quality modeling and to develop air toxics inventories. In this paper, we present results of an extensive review and analysis of available exhaust speciation data for total organic gases (TOG) for spark ignition (SI) engines running on gasoline/ethanol blends now in widespread use, and compression ignition (CI) engines running on diesel fuel. We identified two data sets best suited for development of exhaust speciation profiles. Neither of these data sets have previously been published. We analyzed the resulting speciation profiles for differences in SI engine exhaust composition between 2-stroke and 4-stroke engines using E0 (0% ethanol) and E10 (10% ethanol) blends, and differences in CI engine exhaust composition among engines meeting different emission standards. Exhaust speciation profiles were also analyzed to compare differences in maximum incremental reactivity (MIR) values; this is a useful indicator for evaluating how organic gases may affect ozone formation for air quality modeling. Our analyses found significant differences in speciated emissions from 2-stroke and 4-stroke SI engines, and between engines running on E0 and E10 fuels. We found significant differences in profiles from pre-Tier 1 CI engines, engines meeting Tier 1 standards, and engines meeting Tier 2 standards. Although data for nonroad CI engines meeting tier 4 standards with control devices such as particulate filters and selective catalyst reduction (SCR) devices were not available, data from highway CI engines suggest these technologies will substantially change profiles for nonroad CI engines as well (EPA, 2014c).Implications: The nonroad engine data sets analyzed in this study will substantially improve exhaust speciation profiles used to characterize organic gas emissions from nonroad engines. Since nonroad engines are major contributors to ambient air pollution, these profiles can considerably improve U.S. emission inventories for gaseous air toxics emitted from nonroad engines. The speciation profiles developed in this paper can be used to develop more accurate emission inputs to chemical transport models, leading to more accurate air quality modeling.
C1 [Cook, Rich; Yanca, Catherine A.; Sonntag, Darrell B.] US EPA, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA.
RP Cook, R (reprint author), US EPA, Off Transportat & Air Qual, 2000 Traverwood Dr, Ann Arbor, MI 48105 USA.
EM cook.rich@epa.gov
FU EPA; Department of Energy
FX This work was supported in part by an appointment to the ORISE
participant research program support by an interagency agreement between
EPA and the Department of Energy. This paper may not necessarily reflect
the views of EPA and no official endorsement should be inferred.
NR 26
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Z9 0
U1 3
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 10
BP 1185
EP 1193
DI 10.1080/10962247.2015.1020118
PG 9
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CT3QK
UT WOS:000362721600003
PM 26452015
ER
PT J
AU Lu, Z
Streets, DG
de Foy, B
Lamsal, LN
Duncan, BN
Xing, J
AF Lu, Z.
Streets, D. G.
de Foy, B.
Lamsal, L. N.
Duncan, B. N.
Xing, J.
TI Emissions of nitrogen oxides from US urban areas: estimation from Ozone
Monitoring Instrument retrievals for 2005-2014
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID GOME-SATELLITE-OBSERVATIONS; OMI TROPOSPHERIC NO2; POWER-PLANT PLUMES;
UNITED-STATES; AIR-QUALITY; SPACE; LIFETIMES; TRENDS; SO2; COLUMNS
AB Satellite remote sensing of tropospheric nitrogen dioxide (NO2) can provide valuable information for estimating surface nitrogen oxides (NOx) emissions. Using an exponentially modified Gaussian (EMG) method and taking into account the effect of wind on observed NO2 distributions, we estimate 3-year moving-average emissions of summertime NOx from 35 US (United States) urban areas directly from NO2 retrievals of the Ozone Monitoring Instrument (OMI) during 2005-2014. Following conclusions of previous studies that the EMG method provides robust and accurate emission estimates under strong-wind conditions, we derive top-down NOx emissions from each urban area by applying the EMG method to OMI data with wind speeds greater than 3-5 m s(-1). Meanwhile, we find that OMI NO2 observations under weak-wind conditions (i.e., < 3 m s(-1)) are qualitatively better correlated to the surface NOx source strength in comparison to all-wind OMI maps; therefore, we use them to calculate the satellite-observed NO2 burdens of urban areas and compare with NOx emission estimates. The EMG results show that OMI-derived NOx emissions are highly correlated (R > 0.93) with weak-wind OMI NO2 burdens as well as with bottom-up NOx emission estimates over 35 urban areas, implying a linear response of the OMI observations to surface emissions under weak-wind conditions. The simultaneous EMG-obtained effective NO2 lifetimes (similar to 3.5 +/- 1.3 h), however, are biased low in comparison to the summertime NO2 chemical lifetimes. In general, isolated urban areas with NOx emission intensities greater than similar to 2 Mg h(-1) produce statistically significant weak-wind signals in 3-year average OMI data. From 2005 to 2014, we estimate that total OMI-derived NOx emissions over all selected US urban areas decreased by 49 %, consistent with reductions of 43, 47, 49, and 44 % in the total bottom-up NOx emissions, the sum of weak-wind OMI NO2 columns, the total weak-wind OMI NO2 burdens, and the averaged NO2 concentrations, respectively, reflecting the success of NOx control programs for both mobile sources and power plants. The decrease rates of these NOx-related quantities are found to be faster (i.e., -6.8 to -9.3 % yr(-1)) before 2010 and slower (i.e., -3.4 to -4.9 % yr(-1)) after 2010. For individual urban areas, we calculate the R values of pair-wise trends among the OMI-derived and bottom-up NOx emissions, the weak-wind OMI NO2 burdens, and ground-based NO2 measurements, and high correlations are found for all urban areas (median R= 0.8), particularly large ones (R up to 0.97). The results of the current work indicate that using the EMG method and considering the wind effect, the OMI data allow for the estimation of NOx emissions from urban areas and the direct constraint of emission trends with reasonable accuracy.
C1 [Lu, Z.; Streets, D. G.] Argonne Natl Lab, Div Energy Syst, Argonne, IL 60439 USA.
[de Foy, B.] St Louis Univ, Dept Earth & Atmospher Sci, St Louis, MO 63108 USA.
[Lamsal, L. N.] Univ Space Res Assoc, Goddard Earth Sci Technol & Res, Columbia, MD 21046 USA.
[Lamsal, L. N.; Duncan, B. N.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Xing, J.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Lu, Z (reprint author), Argonne Natl Lab, Div Energy Syst, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM zlu@anl.gov
RI de Foy, Benjamin/A-9902-2010; Duncan, Bryan/A-5962-2011
OI de Foy, Benjamin/0000-0003-4150-9922;
FU National Aeronautics and Space Administration (NASA) as a part of the
Air Quality Applied Sciences Team (AQAST) program; Argonne National
Laboratory is operated by UChicago Argonne, LLC [DE-AC02-06CH11357]
FX This work was sponsored by the National Aeronautics and Space
Administration (NASA) as a part of the Air Quality Applied Sciences Team
(AQAST) program, for which we are grateful to the NASA project officer
John Haynes and the AQAST team leader Daniel Jacob. We acknowledge the
free use of tropospheric NO2 column data from the OMI sensor
available at www.temis.nl. The Argonne National Laboratory is operated
by UChicago Argonne, LLC, under contract no. DE-AC02-06CH11357 with the
US Department of Energy.
NR 61
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Z9 14
U1 5
U2 31
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 18
BP 10367
EP 10383
DI 10.5194/acp-15-10367-2015
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CT0AZ
UT WOS:000362457400009
ER
PT J
AU Teichman, KY
Persily, AK
Emmerich, SJ
AF Teichman, Kevin Y.
Persily, Andrew K.
Emmerich, Steven J.
TI Indoor air quality in high-performing building case studies: Got data?
SO SCIENCE AND TECHNOLOGY FOR THE BUILT ENVIRONMENT
LA English
DT Article
ID ENVIRONMENTS
AB This article is a review of how indoor air quality has been addressed in case studies of high-performing buildings, specifically the case studies described in ASHRAE's High Performing Buildings magazine. Nearly all of the reported case studies address energy performance, both in the design and operation of the building. In contrast, while most case studies mention indoor air quality design considerations, they generally do not address indoor air quality in a comprehensive manner, nor do they present the impacts of indoor air quality-related and other design considerations on indoor concentrations or on the health, comfort, and productivity of building occupants. Based upon this analysis, as well as existing standards and guidelines, a discussion is provided about what indoor air quality information should be collected during the early stages of a building's operation to demonstrate its indoor air quality performance. This information includes (a) documentation of key indoor air quality-related design features and their implementation during building construction, commissioning, and initial operation; (b) collection of indoor air quality performance data, including measured pollutant concentrations and ventilation rates; and (c) assessment of occupant satisfaction using occupant surveys. To facilitate comparisons of indoor air quality performance among buildings, suggestions are provided on how to collect and report this information in a consistent manner.
C1 [Teichman, Kevin Y.] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Persily, Andrew K.; Emmerich, Steven J.] NIST, Gaithersburg, MD 20899 USA.
RP Teichman, KY (reprint author), US EPA, Off Res & Dev, 1200 Penn Ave,NW 8101R, Washington, DC 20460 USA.
EM teichman.kevin@epa.gov
NR 28
TC 1
Z9 1
U1 2
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2374-4731
EI 2374-474X
J9 SCI TECHNOL BUILT EN
JI Sci. Technol. Built Environ.
PY 2015
VL 21
IS 1
SI SI
BP 91
EP 98
DI 10.1080/10789669.2014.976509
PG 8
WC Thermodynamics; Construction & Building Technology; Engineering,
Mechanical
SC Thermodynamics; Construction & Building Technology; Engineering
GA CS4SW
UT WOS:000362067200010
ER
PT J
AU Xing, J
Mathur, R
Pleim, J
Hogrefe, C
Gan, CM
Wong, DC
Wei, C
AF Xing, J.
Mathur, R.
Pleim, J.
Hogrefe, C.
Gan, C. -M.
Wong, D. C.
Wei, C.
TI Can a coupled meteorology-chemistry model reproduce the historical trend
in aerosol direct radiative effects over the Northern Hemisphere?
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID ENERGY SYSTEM CERES; OPTICAL DEPTH; AIR-POLLUTION; IMAGING
SPECTRORADIOMETER; SATELLITE-OBSERVATIONS; ATMOSPHERE RADIATION;
SOLAR-RADIATION; ORGANIC AEROSOL; SOUTHEAST-ASIA; EARTHS SURFACE
AB The ability of a coupled meteorology-chemistry model, i.e., Weather Research and Forecast and Community Multiscale Air Quality (WRF-CMAQ), to reproduce the historical trend in aerosol optical depth (AOD) and clear-sky shortwave radiation (SWR) over the Northern Hemisphere has been evaluated through a comparison of 21-year simulated results with observation-derived records from 1990 to 2010. Six satellite-retrieved AOD products including AVHRR, TOMS, SeaWiFS, MISR, MODIS-Terra and MODIS-Aqua as well as long-term historical records from 11 AERONET sites were used for the comparison of AOD trends. Clear-sky SWR products derived by CERES at both the top of atmosphere (TOA) and surface as well as surface SWR data derived from seven SURFRAD sites were used for the comparison of trends in SWR. The model successfully captured increasing AOD trends along with the corresponding increased TOA SWR (upwelling) and decreased surface SWR (downwelling) in both eastern China and the northern Pacific. The model also captured declining AOD trends along with the corresponding decreased TOA SWR (upwelling) and increased surface SWR (downwelling) in the eastern US, Europe and the northern Atlantic for the period of 2000-2010. However, the model underestimated the AOD over regions with substantial natural dust aerosol contributions, such as the Sahara Desert, Arabian Desert, central Atlantic and northern Indian Ocean. Estimates of the aerosol direct radiative effect (DRE) at TOA are comparable with those derived by measurements. Compared to global climate models (GCMs), the model exhibits better estimates of surface-aerosol direct radiative efficiency (E-tau). However, surface-DRE tends to be underestimated due to the underestimated AOD in land and dust regions. Further investigation of TOA-E-tau estimations as well as the dust module used for estimates of windblown-dust emissions is needed.
C1 [Xing, J.; Mathur, R.; Pleim, J.; Hogrefe, C.; Gan, C. -M.; Wong, D. C.; Wei, C.] US EPA, Durham, NC 27711 USA.
[Wei, C.] Max Planck Inst Chem, Multiphase Chem Dept, D-55128 Mainz, Germany.
RP Xing, J (reprint author), US EPA, Res Triangle Pk, Durham, NC 27711 USA.
EM xing.jia@epa.gov
RI wei, chao/E-4379-2011; Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
FU Department of Energy project (IA) [DE-SC000378]; EPA (IA) [RW-89-9233260
1]; National Research Council Research Associateship Award at the US EPA
FX This work was supported in part by an inter-agency agreement between the
Department of Energy project (IA number is DE-SC000378) and the EPA (IA
number is RW-89-9233260 1). This research was performed while Jia Xing
and Chuen-Meei Gan held a National Research Council Research
Associateship Award at the US EPA. The authors gratefully acknowledge
the availability of AVHRR, TOMS, SeaWiFS, MISR, MODIS-Terra and
MODIS-Aqua, CERES, AERONET, and SURFRAD data.
NR 77
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U1 3
U2 11
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 17
BP 9997
EP 10018
DI 10.5194/acp-15-9997-2015
PG 22
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CR7YH
UT WOS:000361567600016
ER
PT B
AU El-Masri, H
McLanahan, E
Martin, S
AF El-Masri, Hisham
McLanahan, Eva
Martin, Sheppard
BE AbouDonia, MB
TI Principles of Toxicokinetics and Predictive Toxicokinetics Modeling
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID DERMAL ABSORPTION; PHARMACOKINETIC MODEL; PBPK MODEL;
PERCUTANEOUS-ABSORPTION; BREATH CONCENTRATIONS; INHALATION EXPOSURE;
HUMANS; RATS; CHLOROFORM; OCTAMETHYLCYCLOTETRASILOXANE
C1 [El-Masri, Hisham] US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[McLanahan, Eva] US PHS, Div Community Hlth Invest, Agcy Tox Subst & Dis Registry, Atlanta, GA USA.
[Martin, Sheppard] Procter & Gamble Co, Cent Prod Safety, Cincinnati, OH USA.
RP El-Masri, H (reprint author), US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA.
NR 28
TC 0
Z9 0
U1 0
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 85
EP 99
PG 15
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100006
ER
PT B
AU Louis, G
Stoker, T
AF Louis, Gwendolyn
Stoker, Tammy
BE AbouDonia, MB
TI Endocrine Disruptors
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID ARYL-HYDROCARBON RECEPTOR; BROMINATED FLAME RETARDANTS; BREAST-CANCER
CELLS; CONSTITUTIVE ANDROSTANE RECEPTOR; ADRENOCORTICAL CARCINOMA-CELLS;
SPRAGUE-DAWLEY RATS; EXPOSED IN-UTERO; GENE-EXPRESSION; FEMALE RAT;
REPRODUCTIVE DEVELOPMENT
C1 [Louis, Gwendolyn; Stoker, Tammy] US EPA, Endocrine Toxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27709 USA.
RP Louis, G (reprint author), US EPA, Endocrine Toxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27709 USA.
NR 134
TC 1
Z9 1
U1 0
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 289
EP 308
PG 20
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100015
ER
PT B
AU Luebke, RW
AF Luebke, Robert W.
BE AbouDonia, MB
TI Immune System Toxicity and Immunotoxicity Hazard Identification
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID FOOD ALLERGY; INFLUENZA INFECTION; AUTOIMMUNE-DISEASES;
ANTIBODY-RESPONSE; CHRONIC STRESS; SEX-HORMONES; EXPOSED MICE; LEAD;
SUSCEPTIBILITY; INFLAMMATION
C1 US EPA, Cardiovasc & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA.
RP Luebke, RW (reprint author), US EPA, Cardiovasc & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA.
NR 51
TC 0
Z9 0
U1 1
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 323
EP 339
PG 17
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100017
ER
PT B
AU Klinefelter, GR
AF Klinefelter, Gary R.
BE AbouDonia, MB
TI Male Reproductive Toxicology: Environmental Exposures versus
Reproductive Competence
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID ENDOCRINE DISRUPTION; SPERM; RAT; FERTILITY; TESTIS; ANTIANDROGENS;
PHTHALATE; ANIMALS; SEMEN; SP22
C1 US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Durham, NC 27708 USA.
RP Klinefelter, GR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Durham, NC 27708 USA.
NR 35
TC 0
Z9 0
U1 0
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 472
EP 491
PG 20
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100022
ER
PT B
AU Goldman, JM
Cooper, RL
AF Goldman, Jerome M.
Cooper, Ralph L.
BE AbouDonia, MB
TI Female Reproductive Toxicology
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID LUTEINIZING-HORMONE SURGE; MENSTRUAL-CYCLE CHARACTERISTICS;
SPRAGUE-DAWLEY RATS; SEXUAL-DIFFERENTIATION; ESTROUS-CYCLE; MAMMALIAN
OVA; BISPHENOL-A; IN-UTERO; HYPOTHALAMIC CATECHOLAMINES;
POLYCHLORINATED-BIPHENYLS
C1 [Goldman, Jerome M.; Cooper, Ralph L.] US EPA, Endocrine Toxicol Branch, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27708 USA.
RP Goldman, JM (reprint author), US EPA, Endocrine Toxicol Branch, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Durham, NC 27708 USA.
NR 142
TC 0
Z9 0
U1 0
U2 0
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 493
EP 517
PG 25
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100023
ER
PT B
AU Farraj, AK
Hazari, MS
Costa, DL
AF Farraj, Aimen K.
Hazari, Mehdi S.
Costa, Daniel L.
BE AbouDonia, MB
TI Pulmonary Toxicology
SO MAMMALIAN TOXICOLOGY
LA English
DT Article; Book Chapter
ID GENETIC SUSCEPTIBILITY; TRIMELLITIC ANHYDRIDE; AIR-POLLUTION; TOXICITY;
LUNG; MECHANISMS; EXPOSURE; ASBESTOS; ASTHMA; PNEUMOCONIOSIS
C1 [Farraj, Aimen K.; Hazari, Mehdi S.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Durham, NC 27708 USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Farraj, AK (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Durham, NC 27708 USA.
NR 73
TC 0
Z9 0
U1 1
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-118-68348-4; 978-1-119-94041-8
PY 2015
BP 519
EP 538
PG 20
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA BD5RT
UT WOS:000361757100024
ER
PT J
AU Spassova, MA
Miller, DJ
Nikolov, AS
AF Spassova, Maria A.
Miller, David J.
Nikolov, Alexander S.
TI Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging
and DNA Repair Processes in Shaping the Dose-Response Curve of
KBrO3-Induced DNA Damage
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID CONTINUOUS END-POINTS; POTASSIUM BROMATE; OXIDATIVE STRESS;
RISK-ASSESSMENT; CELL-PROLIFERATION; GENETIC TOXICOLOGY; IWGT REPORT;
CARCINOGENICITY; MUTAGENICITY; KIDNEYS
AB We have developed a kinetic model to investigate how DNA repair processes and scavengers of reactive oxygen species (ROS) can affect the dose-response shape of prooxidant induced DNA damage. We used as an example chemical KBrO3 which is activated by glutathione and forms reactive intermediates that directly interact with DNA to form 8-hydroxy-2-deoxyguanosine DNA adducts (8-OH-dG). The single strand breaks (SSB) that can result from failed base excision repair of these adducts were considered as an effect downstream from 8-OH-dG. We previously demonstrated that, in the presence of effective base excision repair, 8-OH-dG can exhibit threshold-like dose-response dependence, while the downstream SSB can still exhibit a linear dose-response. Here we demonstrate that this result holds for a variety of conditions, including low levels of GSH, the presence of additional SSB repair mechanisms, or a scavenger. It has been shown that melatonin, a terminal scavenger, inhibits KBrO3-caused oxidative damage. Our modeling revealed that sustained exposure to KBrO3 can lead to fast scavenger exhaustion, in which case the dose-response shapes for both endpoints are not substantially affected. The results are important to consider when forming conclusions on a chemical's toxicity dose dependence based on the dose-response of early genotoxic events.
C1 [Spassova, Maria A.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Miller, David J.] NCI, Div Canc Biol, NIH, Rockville, MD 20892 USA.
[Nikolov, Alexander S.] Langley High Sch, Mclean, VA 22101 USA.
RP Spassova, MA (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
EM spassova.maria@epa.gov
NR 36
TC 3
Z9 3
U1 0
U2 2
PU HINDAWI PUBLISHING CORP
PI NEW YORK
PA 315 MADISON AVE 3RD FLR, STE 3070, NEW YORK, NY 10017 USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
AR 764375
DI 10.1155/2015/764375
PG 12
WC Cell Biology
SC Cell Biology
GA CR9HB
UT WOS:000361664000001
ER
PT J
AU Williams, WC
Lehmann, JR
Boykin, E
Selgrade, MK
Lehmann, DM
AF Williams, W. C.
Lehmann, J. R.
Boykin, E.
Selgrade, M. K.
Lehmann, D. M.
TI Lung function changes in mice sensitized to ammonium hexachloroplatinate
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Ammonium hexachloroplatinate; occupational asthma; platinum; pulmonary
hyperresponsiveness; respiratory hypersensitivity; whole-body
plethysmography
ID TRIMELLITIC ANHYDRIDE POWDER; PLATINUM REFINERY WORKERS; ONLY INHALATION
EXPOSURE; TOLUENE DIISOCYANATE TDI; ALLERGIC AIRWAYS DISEASE; GROUP
METAL-SALTS; DERMAL SENSITIZATION; OCCUPATIONAL ASTHMA;
ANTIBODY-PRODUCTION; COMPLEX SALTS
AB Occupational exposure to halogenated platinum salts can trigger the development of asthma. The risk to the general population that may result from the use of platinum in catalytic converters and its emerging use as a diesel fuel additive is unclear. To investigate pulmonary responses to platinum, we developed a mouse model of platinum hypersensitivity. Mice were sensitized through application of ammonium hexachloroplatinate (AHCP) to the shaved back on days 0, 5 and 19, and to each ear on days 10, 11 and 12. On days 24 and 29, mice were challenged by oropharyngeal aspiration with AHCP in saline. Before and immediately after challenge, pulmonary responses were assessed using whole body plethysmography (WBP). A dose-dependent increase in immediate responses was observed in AHCP-sensitized and challenged mice. On days 26 and 31, changes in ventilatory responses to methacholine (Mch) aerosol were assessed by WBP; dose-dependent increases in Mch responsiveness occurred in sensitized mice. Lymph node cell counts indicate a proliferative response in lymph nodes draining the sites of application. Bronchoalveolar lavage fluid harvested from sensitized mice contained an average of 5% eosinophils compared to less than 0.5% in non-sensitized mice (p<0.05); significant increases in total serum immunoglobulin E were observed for all sensitized mice. Although a second airway challenge on day 29 affected some results, only one airway challenge was needed to observe changes in lung function.
C1 [Williams, W. C.; Lehmann, J. R.; Boykin, E.; Lehmann, D. M.] US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Lab NHEERL, Res Triangle Pk, NC 27711 USA.
[Selgrade, M. K.] ICF Int, Fairfax, VA USA.
RP Lehmann, DM (reprint author), US EPA, EPHD Cardiopulm & Immunotoxicol Branch, NHEERL, Mail Drop B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM lehmann.david@epa.gov
NR 87
TC 0
Z9 0
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PY 2015
VL 27
IS 10
BP 468
EP 480
DI 10.3109/08958378.2015.1070219
PG 13
WC Toxicology
SC Toxicology
GA CR4TN
UT WOS:000361332100003
PM 26309092
ER
PT J
AU Budisulistiorini, SH
Li, X
Bairai, ST
Renfro, J
Liu, Y
Liu, YJ
McKinney, KA
Martin, ST
McNeill, VF
Pye, HOT
Nenes, A
Neff, ME
Stone, EA
Mueller, S
Knote, C
Shaw, SL
Zhang, Z
Gold, A
Surratt, JD
AF Budisulistiorini, S. H.
Li, X.
Bairai, S. T.
Renfro, J.
Liu, Y.
Liu, Y. J.
McKinney, K. A.
Martin, S. T.
McNeill, V. F.
Pye, H. O. T.
Nenes, A.
Neff, M. E.
Stone, E. A.
Mueller, S.
Knote, C.
Shaw, S. L.
Zhang, Z.
Gold, A.
Surratt, J. D.
TI Examining the effects of anthropogenic emissions on isoprene-derived
secondary organic aerosol formation during the 2013 Southern Oxidant and
Aerosol Study (SOAS) at the Look Rock, Tennessee ground site
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID POSITIVE MATRIX FACTORIZATION; IONIZATION MASS-SPECTROMETRY; CHEMICAL
SPECIATION MONITOR; SOUTHEASTERN UNITED-STATES; FINE-PARTICLE WATER;
REACTIVE UPTAKE; ATMOSPHERIC AEROSOLS; AMBIENT AEROSOL; ORGANOSULFATE
FORMATION; 2-METHYLGLYCERIC ACID
AB A suite of offline and real-time gas-and particlephase measurements was deployed at Look Rock, Tennessee (TN), during the 2013 Southern Oxidant and Aerosol Study (SOAS) to examine the effects of anthropogenic emissions on isoprene-derived secondary organic aerosol (SOA) formation. High-and low-time-resolution PM2.5 samples were collected for analysis of known tracer compounds in isoprene-derived SOA by gas chromatography/electron ionizationmass spectrometry (GC/EI-MS) and ultra performance liquid chromatography/diode array detection-electrospray ionization-high-resolution quadrupole time-of-flight mass spectrometry (UPLC/DAD-ESI-HR-QTOFMS). Source apportionment of the organic aerosol (OA) was determined by positive matrix factorization (PMF) analysis of mass spectro-metric data acquired on an Aerodyne Aerosol Chemical Speciation Monitor (ACSM). Campaign average mass concentrations of the sum of quantified isoprene-derived SOA tracers contributed to similar to 9% (up to 28 %) of the total OA mass, with isoprene-epoxydiol (IEPOX) chemistry accounting for similar to 97% of the quantified tracers. PMF analysis resolved a factor with a profile similar to the IEPOX-OA factor resolved in an Atlanta study and was therefore designated IEPOX-OA. This factor was strongly correlated (r(2) > 0.7) with 2-methyltetrols, C5-alkene triols, IEPOX-derived organosulfates, and dimers of organosulfates, confirming the role of IEPOX chemistry as the source. On average, IEPOX-derived SOA tracer mass was similar to 26% (up to 49 %) of the IEPOX-OA factor mass, which accounted for 32% of the total OA. A low-volatility oxygenated organic aerosol (LV-OOA) and an oxidized factor with a profile similar to 91Fac observed in areas where emissions are biogenic-dominated were also resolved by PMF analysis, whereas no primary organic aerosol (POA) sources could be resolved. These findings were consistent with low levels of primary pollutants, such as nitric oxide (NO similar to 0.03 ppb), carbon monoxide (CO similar to 116 ppb), and black carbon (BC similar to 0.2 mu g m(-3)). Particle-phase sulfate is fairly correlated (r(2) similar to 0.3) with both methacrylic acid epoxide (MAE)/hydroxymethyl-methyl-ff lactone (HMML)-(henceforth called methacrolein (MACR)derived SOA tracers) and IEPOX-derived SOA tracers, and more strongly correlated (r(2) similar to 0.6) with the IEPOX-OA factor, in sum suggesting an important role of sulfate in isoprene SOA formation. Moderate correlation between the MACR-derived SOA tracer 2-methylglyceric acid with sum of reactive and reservoir nitrogen oxides (NOy; r(2) = 0.38) and nitrate (r(2) = 0.45) indicates the potential influence of anthropogenic emissions through long-range transport. Despite the lack of a clear association of IEPOX-OA with locally estimated aerosol acidity and liquid water content (LWC), box model calculations of IEPOX uptake using the simpleGAMMA model, accounting for the role of acidity and aerosol water, predicted the abundance of the IEPOX-derived SOA tracers 2-methyltetrols and the corresponding sulfates with good accuracy (r(2) similar to 0.5 and similar to 0.7, respectively). The modeling and data combined suggest an anthropogenic influence on isoprene-derived SOA formation through acid-catalyzed heterogeneous chemistry of IEPOX in the southeastern US. However, it appears that this process was not limited by aerosol acidity or LWC at Look Rock during SOAS.
Future studies should further explore the extent to which acidity and LWC as well as aerosol viscosity and morphology becomes a limiting factor of IEPOX-derived SOA, and their modulation by anthropogenic emissions.
C1 [Budisulistiorini, S. H.; Li, X.; Zhang, Z.; Gold, A.; Surratt, J. D.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA.
[Bairai, S. T.; Mueller, S.] Tennessee Valley Author, Muscle Shoals, AL 35660 USA.
[Renfro, J.] Natl Pk Serv, Gatlinburg, TN USA.
[Liu, Y.; Liu, Y. J.; McKinney, K. A.; Martin, S. T.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
[McNeill, V. F.] Columbia Univ, Dept Chem Engn, New York, NY USA.
[Budisulistiorini, S. H.; Pye, H. O. T.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Nenes, A.] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Nenes, A.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.
[Nenes, A.] Hellas, Fdn Res & Technol, ICE HT, Patras, Greece.
[Neff, M. E.; Stone, E. A.] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA.
[Knote, C.] Univ Munich, Dept Expt Meteorol, Munich, Germany.
[Shaw, S. L.] Elect Power Res Inst, Palo Alto, CA USA.
RP Surratt, JD (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27514 USA.
EM surratt@unc.edu
RI Martin, Scot/G-1094-2015; Knote, Christoph/A-9809-2010; Surratt,
Jason/D-3611-2009; Pye, Havala/F-5392-2012
OI Martin, Scot/0000-0002-8996-7554; Knote, Christoph/0000-0001-9105-9179;
Surratt, Jason/0000-0002-6833-1450; Pye, Havala/0000-0002-2014-2140
FU US Environmental Protection Agency (EPA) [835404]; Electric Power
Research Institute (EPRI); National Oceanic and Atmospheric
Administration (NOAA) Climate Program Office [NA13OAR4310064]; Fulbright
Presidential Fellowship; UNC Graduate School Off-Campus Dissertation
Research Fellowship; US EPA Science to Achieve Results (STAR) program
[835401]
FX This work was funded by the US Environmental Protection Agency (EPA)
through grant number 835404. The contents of this publication are solely
the responsibility of the authors and do not necessarily represent the
official views of the US EPA. Further, the US EPA does not endorse the
purchase of any commercial products or services mentioned in the
publication. The US EPA through its Office of Research and Development
collaborated in the research described here. It has been subjected to
Agency review and approved for publication, but may not necessarily
reflect official Agency policy. The author would also like to thank the
Electric Power Research Institute (EPRI) for their support. This study
was supported in part by the National Oceanic and Atmospheric
Administration (NOAA) Climate Program Office's AC4 program, award #
NA13OAR4310064. We thank Bill Hicks of the Tennessee Valley Authority
(TVA) for his assistance in collecting the collocated monitoring data at
the LRK site. S. H. Budisulistiorini was supported by a Fulbright
Presidential Fellowship (2010-2013) for attending the University of
North Carolina at Chapel Hill and the UNC Graduate School Off-Campus
Dissertation Research Fellowship, as well as partial appointment to the
Internship/Research Participation Program at the Office of Research and
Development, US EPA, administered by the Oak Ridge Institute for Science
and Education through an interagency agreement between the US Department
of Energy and EPA. M. Neff and E. A. Stone were supported by US EPA
Science to Achieve Results (STAR) program grant number 835401. The
authors thank Lynn Russell, Timothy Bertram and Christopher Cappa as
well as their respective groups for their collaboration during the SOAS
campaign at LRK. The authors thank Louisa Emmons for her assistance with
forecasts made available during the SOAS campaign. The authors thank
John Offenberg for providing access to a Sunset Laboratory OC/EC
analysis instrument. The authors also thank Tianqu Cui for his
assistance in helping deploy instrumentation from the UNC group, and
Wendy Marth and Theran Riedel for their assistance in helping calibrate
the acetate CIMS. We would like to thank Annmarie Carlton, Joost deGouw,
Jose Jimenez, and Allen Goldstein for helping to organize the SOAS
campaign and coordinating communication between ground sites.
NR 86
TC 32
Z9 32
U1 23
U2 82
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 15
BP 8871
EP 8888
DI 10.5194/acp-15-8871-2015
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CP5UI
UT WOS:000359949700019
ER
PT J
AU Yahya, K
Wang, K
Zhang, Y
Kleindienst, TE
AF Yahya, K.
Wang, K.
Zhang, Y.
Kleindienst, T. E.
TI Application of WRF/Chem over North America under the AQMEII Phase 2-Part
2: Evaluation of 2010 application and responses of air quality and
meteorology-chemistry interactions to changes in emissions and
meteorology from 2006 to 2010
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; EXTREME HEAT EVENTS; UNITED-STATES;
CLIMATE-CHANGE; REGIONAL CLIMATE; US; IMPACTS; OZONE; PARAMETERIZATION;
MODELS
AB The Weather Research and Forecasting model with Chemistry (WRF/Chem) simulation with the 2005 Carbon Bond (CB05) gas-phase mechanism coupled to the Modal for Aerosol Dynamics for Europe (MADE) and the volatility basis set approach for secondary organic aerosol (SOA) are conducted over a domain in North America for 2006 and 2010 as part of the Air Quality Model Evaluation International Initiative (AQMEII) Phase 2 project. Following the Part 1 paper that focuses on the evaluation of the 2006 simulations, this Part 2 paper focuses on a comparison of model performance in 2006 and 2010 as well as analysis of the responses of air quality and meteorology-chemistry interactions to changes in emissions and meteorology from 2006 to 2010. In general, emissions for gaseous and aerosol species decrease from 2006 to 2010, leading to a reduction in gaseous and aerosol concentrations and associated changes in radiation and cloud variables due to various feedback mechanisms. WRF/Chem is able to reproduce most observations and the observed variation trends from 2006 to 2010, despite its slightly worse performance than WRF that is likely due to inaccurate chemistry feedbacks resulting from less accurate emissions and chemical boundary conditions (BCONs) in 2010. Compared to 2006, the performance for most meteorological variables in 2010 gives lower normalized mean biases but higher normalized mean errors and lower correlation coefficients. The model also shows poorer performance for most chemical variables in 2010. This could be attributed to underestimations in emissions of some species, such as primary organic aerosol in some areas of the US in 2010, and inaccurate chemical BCONs and meteorological predictions. The inclusion of chemical feedbacks in WRF/Chem reduces biases in meteorological predictions in 2010; however, it increases errors and weakens correlations comparing to WRF simulations. Sensitivity simulations show that the net changes in meteorological variables from 2006 to 2010 are mostly influenced by changes in meteorology and those of ozone and fine particulate matter are influenced to a large extent by emissions and/or chemical BCONs and to a lesser extent by changes in meteorology. Using a different set of emissions and/or chemical BCONs helps improve the performance of individual variables, although it does not improve the degree of agreement with observed interannual trends. These results indicate a need to further improve the accuracy and consistency of emissions and chemical BCONs, the representations of SOA and chemistry-meteorology feedbacks in the online-coupled models.
C1 [Yahya, K.; Wang, K.; Zhang, Y.] NCSU, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Kleindienst, T. E.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Zhang, Y (reprint author), NCSU, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
EM yzhang9@ncsu.edu
RI Wang, Kai/D-4262-2013
OI Wang, Kai/0000-0002-2375-5989
FU National Science Foundation [ACI-1053575]; National Science Foundation
and Information Systems Laboratory at NCSU; National Science Foundation
and Stampede; National Science Foundation EaSM program at NCSU
[AGS-1049200]
FX This study is funded by the National Science Foundation EaSM program
(AGS-1049200) at NCSU. The following agencies have prepared the data
sets used in this study: the U.S. EPA (North American emissions
processing), Environment Canada, Mexican Secretariat of the Environment
and Natural Resources (Secretaria del Medio Ambiente y Recursos
Naturales, SE-MARNAT) and National Institute of Ecology (Instituto
Nacional de Ecologia - INE) (North American national emissions
inventories), the European Centre for Medium Range Weather Forecasting
Global and Regional Earth-system (Atmosphere) Monitoring using Satellite
and in situ data (ECMWF/GEMS) project and Meteo France/Centre national
de recherches meteorologiques (CNRM-GAME) for the Monitoring Atmospheric
Composition and Climate (MACC) ICONs/BCONs. Meteorological ICONs/BCONs
are provided by the National Center for Environmental Protection.
Ambient North American concentration measurements are provided by
several US networks (AQS, CASTNET, IMPROVE, SEARCH, and STN). North
American precipitation-chemistry measurements are provided by several US
networks (CASTNET, and NADP). GPCC precipitation data are provided by
the National Oceanic and Atmospheric Administration's Earth System
Research Laboratory in the Physical Sciences Division (NOAA/OAR/ESRL
PSD), Boulder, Colorado, USA, from their web site at
http://www.esrl.noaa.gov/psd/. The 2006 and 2010 SOA/OC data at RTP, NC,
Bakersfield and Pasadena, CA, were provided by John Offenberg, U.S. EPA.
Cloud variables were provided by MODIS. We thank Georg Grell, NOAA,
Christian Hogrefe, US EPA, Paul Makar, Environment Canada, Christoph
Knote, NCAR, and Patrick Campbell, NCSU, for helpful discussions on
inputs and outputs of AQMEII model intercomparison. We would also like
to acknowledge high-performance computing support from Yellowstone
(ark:/85065/d7wd3xhc) provided by NCAR's Computational and Information
Systems Laboratory, sponsored by the National Science Foundation and
Information Systems Laboratory, sponsored by the National Science
Foundation and Stampede, provided as an Extreme Science and Engineering
Discovery Environment (XSEDE) digital service by the Texas Advanced
Computing Center (TACC) (http://www.tacc.utexas.edu), which is supported
by National Science Foundation grant number ACI-1053575.
NR 51
TC 5
Z9 6
U1 1
U2 12
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 7
BP 2095
EP 2117
DI 10.5194/gmd-8-2095-2015
PG 23
WC Geosciences, Multidisciplinary
SC Geology
GA CO1LQ
UT WOS:000358917100011
ER
PT J
AU Sproles, EA
Leibowitz, SG
Reager, JT
Wigington, PJ
Famiglietti, JS
Patil, SD
AF Sproles, E. A.
Leibowitz, S. G.
Reager, J. T.
Wigington, P. J., Jr.
Famiglietti, J. S.
Patil, S. D.
TI GRACE storage-runoff hystereses reveal the dynamics of regional
watersheds
SO HYDROLOGY AND EARTH SYSTEM SCIENCES
LA English
DT Article
ID WESTERN UNITED-STATES; DATA ASSIMILATION SYSTEM; CLIMATE-CHANGE;
GROUNDWATER DEPLETION; OREGON CASCADES; SOIL-MOISTURE; RIVER-BASIN;
MOUNTAIN HYDROLOGY; SNOWPACK; MODEL
AB We characterize how regional watersheds function as simple, dynamic systems through a series of hysteresis loops using measurements from NASA's Gravity Recovery and Climate Experiment (GRACE) satellites. These loops illustrate the temporal relationship between runoff and terrestrial water storage in three regional-scale watersheds (> 150 000 km(2)) of the Columbia River Basin, USA and Canada. The shape and size of the hysteresis loops are controlled by the climate, topography, and geology of the watershed. The direction of the hystereses for the GRACE signals moves in opposite directions from the isolated groundwater hystereses. The subsurface water (soil moisture and groundwater) hystereses more closely resemble the storage-runoff relationship of a soil matrix. While the physical processes underlying these hystereses are inherently complex, the vertical integration of terrestrial water in the GRACE signal encapsulates the processes that govern the non-linear function of regional-scale watersheds. We use this process-based understanding to test how GRACE data can be applied prognostically to predict seasonal runoff (mean Nash-Sutcliffe Efficiency of 0.91) and monthly runoff during the low flow/high demand month of August (mean Nash-Sutcliffe Efficiency of 0.77) in all three watersheds. The global nature of GRACE data allows this same methodology to be applied in other regional-scale studies, and could be particularly useful in regions with minimal data and in trans-boundary watersheds.
C1 [Sproles, E. A.] US EPA, Natl Hlth & Environm Effects Res Lab, Oak Ridge Inst Sci & Technol, Corvallis, OR 97333 USA.
[Sproles, E. A.] Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA.
[Leibowitz, S. G.; Wigington, P. J., Jr.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Reager, J. T.; Famiglietti, J. S.] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA.
[Patil, S. D.] Bangor Univ, Sch Environm Nat Resources & Geog, Bangor LL57 2UW, Gwynedd, Wales.
[Sproles, E. A.] Univ La Serena, Ctr Estudios Avanzados Zonas Aridas, La Serena 1305, Chile.
RP Sproles, EA (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Oak Ridge Inst Sci & Technol, 200 SW 35th St, Corvallis, OR 97333 USA.
EM eric.sproles@gmail.com
RI Patil, Sopan/E-8497-2011;
OI Patil, Sopan/0000-0002-8575-5220; Sproles, Eric/0000-0003-1245-1653
FU NASA MEaSUREs Program; US Environmental Protection Agency
FX The authors would like to thank Matthew Rodell and Felix Landerer for
their expertise in understanding GRACE data during the initial stages of
the research. GRACE terrestrial data were processed by Sean Swenson,
supported by the NASA MEaSUREs Program, and are available at
http://grace.jpl.nasa.gov. The GLDAS and NLDAS data used in this study
were acquired as part of the mission of NASA's Earth Science Division
and archived and distributed by the Goddard Earth Sciences Data and
Information Services Center. We would like to thank the reviewers of the
manuscript that have helped improve its overall quality. Additionally,
Tim Kerr provided objective feedback and comments on the research
findings. The information in this document has been funded entirely by
the US Environmental Protection Agency, in part by an appointment to the
Internship/Research Participation Program at the Office of Research and
Development, U.S. Environmental Protection Agency, administered by the
Oak Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and EPA. This manuscript
has been subjected to Agency review and has been approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 75
TC 3
Z9 3
U1 3
U2 16
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1027-5606
EI 1607-7938
J9 HYDROL EARTH SYST SC
JI Hydrol. Earth Syst. Sci.
PY 2015
VL 19
IS 7
BP 3253
EP 3272
DI 10.5194/hess-19-3253-2015
PG 20
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA CO1MA
UT WOS:000358918200016
ER
PT S
AU Harper, S
Wohlleben, W
Doa, M
Nowack, B
Clancy, S
Canady, R
Maynard, A
AF Harper, Stacey
Wohlleben, Wendel
Doa, Maria
Nowack, Bernd
Clancy, Shaun
Canady, Richard
Maynard, Andrew
GP IOP
TI Measuring Nanomaterial Release from Carbon Nanotube Composites: Review
of the State of the Science
SO 4TH INTERNATIONAL CONFERENCE ON SAFE PRODUCTION AND USE OF NANOMATERIALS
(NANOSAFE2014)
SE Journal of Physics Conference Series
LA English
DT Proceedings Paper
CT 4th International Conference on Safe Production and Use of Nanomaterials
(Nanosafe)
CY NOV 18-20, 2014
CL Grenoble, FRANCE
ID EPOXY-BASED NANOCOMPOSITE; NANOPARTICLE RELEASE; POLYMER COMPOSITES;
POTENTIAL RELEASE; LIFE-CYCLE; ENGINEERED NANOMATERIALS; AIRBORNE
PARTICLES; EXPOSURE; ENVIRONMENT; SCENARIOS
AB Hazard studies of "as-produced" nanomaterials are increasingly available, yet a critical gap exists in exposure science that may impede safe development of nanomaterials. The gap is that we do not understand what is actually released because nanomaterials can change when released in ways that are not understood. We also generally do not have methods capable of quantitatively measuring what is released to support dose assessment. This review presents a case study of multi-walled carbon nanotubes (MWCNTs) for the measurement challenge to bridge this gap. As the use and value of MWCNTs increases, methods to measure what is released in ways relevant to risk evaluation are critically needed if products containing these materials are to be economically, environmentally, and socially sustainable. This review draws on the input of over 50 experts engaged in a program of workshops and technical report writing to address the release of MWCNTs from nanocomposite materials across their life cycle. The expert analyses reveals that new and sophisticated methods are required to measure and assess MWCNT exposures for realistic exposure scenarios. Furthermore, method requirements vary with the materials and conditions of release across life cycle stages of products. While review shows that the likelihood of significant release of MWCNTs appears to be low for many stages of composite life cycle, measurement methods are needed so that exposures from MWCNT-composites are understood and managed. In addition, there is an immediate need to refocus attention from study of "as-produced" nanomaterials to coordinated research on actual release scenarios.
C1 [Harper, Stacey] Oregon State Univ, Environm & Mol Toxicol, Chem Biol & Environm Engn, Corvallis, OR 97331 USA.
[Wohlleben, Wendel] BASF SE, Mat Phys, D-67056 Ludwigshafen, Germany.
[Doa, Maria] US EPA, Washington, DC 20460 USA.
[Nowack, Bernd] EMPA, Swiss Fed Labs Mat Sci & Technol, Technol & Soc Lab, CH-9014 St Gallen, Switzerland.
[Clancy, Shaun] Evonik Corp, Parsippany, NJ 07054 USA.
[Canady, Richard] ILSI Res Fdn, Ctr Risk Sci Innovat & Applicat, Washington, DC 20005 USA.
[Maynard, Andrew] Univ Michigan, Risk Sci Ctr, Ann Arbor, MI 48109 USA.
RP Harper, S (reprint author), Oregon State Univ, Environm & Mol Toxicol, Chem Biol & Environm Engn, Corvallis, OR 97331 USA.
EM rcanady@ilsi.org
RI Nowack, Bernd/B-6425-2008
OI Nowack, Bernd/0000-0002-5676-112X
NR 90
TC 4
Z9 4
U1 2
U2 17
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 1742-6588
J9 J PHYS CONF SER
PY 2015
VL 617
AR 012026
DI 10.1088/1742-6596/617/1/012026
PG 19
WC Nanoscience & Nanotechnology; Physics, Multidisciplinary
SC Science & Technology - Other Topics; Physics
GA BD1HU
UT WOS:000358033300026
ER
PT J
AU Fu, X
Wang, SX
Ran, LM
Pleim, JE
Cooter, E
Bash, JO
Benson, V
Hao, JM
AF Fu, X.
Wang, S. X.
Ran, L. M.
Pleim, J. E.
Cooter, E.
Bash, J. O.
Benson, V.
Hao, J. M.
TI Estimating NH3 emissions from agricultural fertilizer application in
China using the bi-directional CMAQ model coupled to an agro-ecosystem
model
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID YANGTZE-RIVER DELTA; AIR-QUALITY MODELS; AMMONIA EMISSIONS; ATMOSPHERE
EXCHANGE; NITROGEN DEPOSITION; PARTICULATE MATTER; INORGANIC AEROSOLS;
MANAGEMENT-SYSTEMS; HAZE POLLUTION; IMPACT
AB Atmospheric ammonia (NH3) plays an important role in atmospheric aerosol chemistry. China is one of the largest NH3 emitting countries with the majority of NH3 emissions coming from agricultural practices, such as fertilizer application and livestock production. The current NH3 emission estimates in China are mainly based on pre-defined emission factors that lack temporal or spatial details, which are needed to accurately predict NH3 emissions. This study provides the first online estimate of NH3 emissions from agricultural fertilizer application in China, using an agricultural fertilizer modeling system which couples a regional air quality model (the Community Multi-scale Air Quality model, or CMAQ) and an agro-ecosystem model (the Environmental Policy Integrated Climate model, or EPIC). This method improves the spatial and temporal resolution of NH3 emissions from this sector.
We combined the cropland area data of 14 crops from 2710 counties with the Moderate Resolution Imaging Spectroradiometer (MODIS) land use data to determine the crop distribution. The fertilizer application rates and methods for different crops were collected at provincial or agricultural region levels. The EPIC outputs of daily fertilizer application and soil characteristics were input into the CMAQ model and the hourly NH3 emissions were calculated online with CMAQ running. The estimated agricultural fertilizer NH3 emissions in this study were approximately 3 Tg in 2011. The regions with the highest modeled emission rates are located in the North China Plain. Seasonally, peak ammonia emissions occur from April to July. Compared with previous researches, this study considers an increased number of influencing factors, such as meteorological fields, soil and fertilizer application, and provides improved NH3 emissions with higher spatial and temporal resolution.
C1 [Fu, X.; Wang, S. X.; Hao, J. M.] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Fu, X.; Wang, S. X.] State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China.
[Ran, L. M.] Univ N Carolina, Inst Environm, Chapel Hill, NC USA.
[Pleim, J. E.; Cooter, E.; Bash, J. O.] US EPA, Res Triangle Pk, NC 27711 USA.
[Benson, V.] Benson Consulting, Columbia, MO USA.
[Hao, J. M.] Tsinghua Univ, Collaborat Innovat Ctr Reg Environm Qual, Beijing 100084, Peoples R China.
RP Wang, SX (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
EM shxwang@tsinghua.edu.cn
RI wang, shuxiao/H-5990-2011; Pleim, Jonathan Pleim/C-1331-2017
OI wang, shuxiao/0000-0001-9727-1963; Pleim, Jonathan
Pleim/0000-0001-6190-6082
FU National Natural Science Foundation of China [21221004]; MEP's special
funds for Research on Public Welfare [201309009, 201409002]; Strategic
Priority Research Program of the Chinese Academy of Sciences
[XBD05020300]
FX This work was sponsored by the National Natural Science Foundation of
China (21221004), MEP's special funds for Research on Public Welfare
(201309009, 201409002), and the Strategic Priority Research Program of
the Chinese Academy of Sciences (XBD05020300). This work was completed
on the "Explorer 100" cluster system of Tsinghua National Laboratory for
Information Science and Technology. The authors also appreciate the help
of Jimmy R. Williams at Texas A&M University, Youlu Bai from the Chinese
Academy of Agriculture Sciences, and Margaret Ledyard-Marks in UNC
Institute for the Environment. Although this work was reviewed by EPA
and approved for publication, it may not necessarily reflect official
agency policy. Mention of commercial products does not constitute
endorsement by the agency.
NR 53
TC 9
Z9 9
U1 13
U2 41
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 12
BP 6637
EP 6649
DI 10.5194/acp-15-6637-2015
PG 13
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CL6ZC
UT WOS:000357117500006
ER
PT J
AU Arcaya, MC
Arcaya, AL
Subramanian, SV
AF Arcaya, Mariana C.
Arcaya, Alyssa L.
Subramanian, S. V.
TI Inequalities in health: definitions, concepts, and theories
SO GLOBAL HEALTH ACTION
LA English
DT Review
DE health disparities; inequality; inequity; theory
ID SOCIAL INEQUALITIES; LIFE EXPECTANCY; SOCIOECONOMIC INEQUALITIES; INCOME
INEQUALITY; MEDICAL GEOGRAPHY; EPIDEMIOLOGY; DETERMINANTS; DISPARITIES;
EQUITY; EXPLANATION
AB Individuals from different backgrounds, social groups, and countries enjoy different levels of health. This article defines and distinguishes between unavoidable health inequalities and unjust and preventable health inequities. We describe the dimensions along which health inequalities are commonly examined, including across the global population, between countries or states, and within geographies, by socially relevant groupings such as race/ethnicity, gender, education, caste, income, occupation, and more. Different theories attempt to explain group-level differences in health, including psychosocial, material deprivation, health behavior, environmental, and selection explanations. Concepts of relative versus absolute; dose-response versus threshold; composition versus context; place versus space; the life course perspective on health; causal pathways to health; conditional health effects; and group-level versus individual differences are vital in understanding health inequalities. We close by reflecting on what conditions make health inequalities unjust, and to consider the merits of policies that prioritize the elimination of health disparities versus those that focus on raising the overall standard of health in a population.
C1 [Arcaya, Mariana C.; Subramanian, S. V.] Boston Univ, Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02215 USA.
[Arcaya, Alyssa L.] US EPA, New York, NY USA.
RP Subramanian, SV (reprint author), Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, 677 Huntington Ave, Boston, MA 02115 USA.
EM svsubram@hsph.harvard.edu
NR 69
TC 6
Z9 6
U1 4
U2 23
PU CO-ACTION PUBLISHING
PI JARFALLA
PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN
SN 1654-9880
J9 GLOBAL HEALTH ACTION
JI Glob. Health Action
PY 2015
VL 8
AR 27106
DI 10.3402/gha.v8.27106
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CL4RL
UT WOS:000356941000001
PM 28156715
ER
PT J
AU Hildenbrand, ZL
Osorio, A
Carlton, DD
Fontenot, BE
Walton, JL
Hunt, LR
Oka, H
Hopkins, D
Bjorndal, B
Schug, KA
AF Hildenbrand, Zacariah L.
Osorio, Alexandra
Carlton, Doug D., Jr.
Fontenot, Brian E.
Walton, Jayme L.
Hunt, Laura R.
Oka, Hyppolite
Hopkins, Dan
Bjorndal, Bryan
Schug, Kevin A.
TI Rapid Analysis of Eukaryotic Bioluminescence to Assess Potential
Groundwater Contamination Events
SO JOURNAL OF CHEMISTRY
LA English
DT Article
ID DRINKING-WATER WELLS; GAS EXTRACTION
AB Here we present data using a bioluminescent dinoflagellate, Pyrocystis lunula, in a toxicological bioassay to rapidly assess potential instances of groundwater contamination associated with natural gas extraction. P. lunula bioluminescence can be quantified using spectrophotometry as a measurement of organismal viability, with normal bioluminescent output declining with increasing concentration(s) of aqueous toxicants. Glutaraldehyde and hydrochloric acid (HCl), components used in hydraulic fracturing and shale acidization, triggered significant toxicological responses in as little as 4 h. Conversely, P. lunula was not affected by the presence of arsenic, selenium, barium, and strontium, naturally occurring heavy metal ions potentially associated with unconventional drilling activities. If exogenous compounds, such as glutaraldehyde and HCl, are thought to have been introduced into groundwater, quantification of P. lunula bioluminescence after exposure to water samples can serve as a cost-effective detection and risk assessment tool to rapidly assess the impact of putative contamination events attributed to unconventional drilling activity.
C1 [Hildenbrand, Zacariah L.; Carlton, Doug D., Jr.; Fontenot, Brian E.; Hunt, Laura R.; Oka, Hyppolite; Schug, Kevin A.] Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA.
[Hildenbrand, Zacariah L.; Carlton, Doug D., Jr.; Fontenot, Brian E.; Hunt, Laura R.; Oka, Hyppolite; Schug, Kevin A.] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA.
[Hildenbrand, Zacariah L.] Inform Environm LLC, Dallas, TX 75206 USA.
[Osorio, Alexandra; Bjorndal, Bryan] Assure Controls Inc, Vista, CA 92081 USA.
[Fontenot, Brian E.; Hunt, Laura R.] US EPA, Water Qual Protect Div, Dallas, TX 75202 USA.
[Walton, Jayme L.] SWCA Environm Consultants, Arlington, TX 76006 USA.
[Hopkins, Dan] Geotech Environm Equipment Inc, Carrollton, TX 75006 USA.
RP Schug, KA (reprint author), Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA.
EM kschug@uta.edu
NR 13
TC 0
Z9 0
U1 4
U2 10
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 2090-9063
EI 2090-9071
J9 J CHEM-NY
JI J. Chem.
PY 2015
AR 957608
DI 10.1155/2015/957608
PG 6
WC Chemistry, Multidisciplinary
SC Chemistry
GA CL2JV
UT WOS:000356770600001
ER
PT J
AU McAlary, T
Groenevelt, H
Disher, S
Arnold, J
Seethapathy, S
Sacco, P
Crump, D
Schumacher, B
Hayes, H
Johnson, P
Gorecki, T
AF McAlary, Todd
Groenevelt, Hester
Disher, Stephen
Arnold, Jason
Seethapathy, Suresh
Sacco, Paolo
Crump, Derrick
Schumacher, Brian
Hayes, Heidi
Johnson, Paul
Gorecki, Tadeusz
TI Passive sampling for volatile organic compounds in indoor air-controlled
laboratory comparison of four sampler types (vol 17, pg 896, 2015)
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Correction
C1 [McAlary, Todd; Groenevelt, Hester] Geosyntec Consultants Inc, Guelph, ON N1G 5G3, Canada.
[Disher, Stephen; Arnold, Jason; Hayes, Heidi] Eurofins Air Tox Inc, Folsom, CA USA.
[Disher, Stephen; Arnold, Jason; Hayes, Heidi] Air Tox Ltd, Folsom, CA USA.
[Seethapathy, Suresh; Gorecki, Tadeusz] Univ Waterloo, Waterloo, ON N2L 3G1, Canada.
[Sacco, Paolo] Fdn Salvatore Maugeri, Padua, Italy.
[Crump, Derrick] Cranfield Univ, Cranfield MK43 0AL, Beds, England.
[Schumacher, Brian] US EPA, Las Vegas, NV 89193 USA.
[Johnson, Paul] Arizona State Univ, Tempe, AZ USA.
RP McAlary, T (reprint author), Geosyntec Consultants Inc, 130 Res Lane 2, Guelph, ON N1G 5G3, Canada.
EM tmcalary@geosyntec.com
NR 1
TC 0
Z9 0
U1 1
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 6
BP 1190
EP 1190
DI 10.1039/c5em90021b
PG 1
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CK2QW
UT WOS:000356057300019
PM 25994121
ER
PT J
AU Collier, SA
Wade, TJ
Sams, EA
Hlavsa, MC
Dufour, AP
Beach, MJ
AF Collier, Sarah A.
Wade, Timothy J.
Sams, Elizabeth A.
Hlavsa, Michele C.
Dufour, Alfred P.
Beach, Michael J.
TI Swimming in the USA: beachgoer characteristics and health outcomes at US
marine and freshwater beaches
SO JOURNAL OF WATER AND HEALTH
LA English
DT Article
DE gastrointestinal illness; health outcomes; healthcare utilization;
natural waters; recreational water; swimming
ID RAPIDLY MEASURED INDICATORS; UNITED-STATES; RECREATIONAL WATER; DISEASE
OUTBREAKS; OTITIS-EXTERNA; ILLNESS; QUALITY; RISK; SURVEILLANCE;
PATHOGENS
AB Swimming in lakes and oceans is popular, but little is known about the demographic characteristics, behaviors, and health risks of beachgoers on a national level. Data from a prospective cohort study of beachgoers at multiple marine and freshwater beaches in the USA were used to describe beachgoer characteristics and health outcomes for swimmers and non-swimmers. This analysis included 54,250 participants. Most (73.2%) entered the water; of those, 65.1% put their head under water, 41.3% got water in their mouth and 18.5% swallowed water. Overall, 16.3% of beachgoers reported any new health problem. Among swimmers, 6.6% reported gastrointestinal (GI) illness compared with 5.5% of non-swimmers (unadjusted chi(2) p < 0.001); 6.0% of swimmers and 4.9% of non-swimmers reported respiratory illness (p < 0.001); 1.8% of swimmers and 1.0% of non-swimmers reported ear problems (p < 0.001); and 3.9% of swimmers and 2.4% of non-swimmers experienced a rash (p < 0.001). Overall, swimmers reported a higher unadjusted incidence of GI illness and earaches than nonswimmers. Current surveillance systems might not detect individual cases and outbreaks of illness associated with swimming in natural water. Better knowledge of beachgoer characteristics, activities, and health risks associated with swimming in natural water can improve disease surveillance and prioritize limited resources.
C1 [Collier, Sarah A.; Hlavsa, Michele C.; Beach, Michael J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Wade, Timothy J.; Sams, Elizabeth A.] US EPA, Off Res & Dev, Chapel Hill, NC USA.
[Dufour, Alfred P.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Collier, SA (reprint author), Ctr Dis Control & Prevent, Mailstop C-09,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM SCollier@cdc.gov
FU Intramural CDC HHS [CC999999]
NR 30
TC 3
Z9 3
U1 1
U2 8
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1477-8920
J9 J WATER HEALTH
JI J. Water Health
PY 2015
VL 13
IS 2
BP 531
EP 543
DI 10.2166/wh.2014.095
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health;
Microbiology; Water Resources
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Microbiology; Water Resources
GA CK2ET
UT WOS:000356024100022
PM 26042984
ER
PT J
AU Ferreira, WR
Ligeiro, R
Macedo, DR
Hughes, RM
Kaufmann, PR
Oliveira, LG
Callisto, M
AF Ferreira, Wander R.
Ligeiro, Raphael
Macedo, Diego R.
Hughes, Robert M.
Kaufmann, Philip R.
Oliveira, Leandro G.
Callisto, Marcos
TI Is the diet of a typical shredder related to the physical habitat of
headwater streams in the Brazilian Cerrado?
SO ANNALES DE LIMNOLOGIE-INTERNATIONAL JOURNAL OF LIMNOLOGY
LA English
DT Article
DE Gut contents; aquatic macroinvertebrates; trophic guilds; tropical
streams; stream habitat conservation
ID PHYLLOICUS SP TRICHOPTERA; LEAF-LITTER; ORGANIC-MATTER; BENTHIC
MACROINVERTEBRATES; HIERARCHICAL FRAMEWORK; ENVIRONMENTAL-FACTORS;
FEEDING PLASTICITY; AUSTRALIAN STREAMS; PARTICULATE MATTER; MULTIMETRIC
INDEX
AB Macroinvertebrates are important for processing leaf detritus in temperate streams, but studies about their role in tropical streams often present conflicting results. Via digestive tract analyses, we assessed the diets of Phylloicus sp. larvae (Trichoptera: Calamoceratidae), collected from streams of two southeastern Brazil river basins (Araguari, Sao Francisco). We classified gut contents as coarse particulate organic matter (CPOM), fine particulate organic matter (FPOM), algae, animal tissue, vascular plant tissue and mineral material. We hypothesized that the diets of Phylloicus larvae would be related to the physical habitat of the streams (e.g., riparian vegetation, organic matter availability and morphological characteristics), larval size and river basin. Although FPOM content predominated in both basins, we found greater CPOM content in Phylloicus larvae of Upper Sao Francisco sites, and this food item was related to greater riparian vegetation canopy density. The FPOM content was greater in larvae of Upper Araguari sites, and this food item was correlated with greater instream brush cover. Algae, animal tissue, vascular plant tissue and mineral material were very rare in the digestive tracts, and therefore could not be explained. These results indicate the importance of riparian vegetation structure in modulating feeding habitats of macroinvertebrates. We conclude that the Phylloicus larvae had more flexibility in what they eat than we might expect based on their traditional classification as shredders. Therefore, trusting in published classifications, ignoring regional or local differences, may be inaccurate. Instead, regional studies of feeding habits are needed for accurate classifications of invertebrate taxa into trophic guilds.
C1 [Ferreira, Wander R.; Ligeiro, Raphael; Macedo, Diego R.; Callisto, Marcos] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Lab Ecol Bentos, BR-31270901 Belo Horizonte, MG, Brazil.
[Macedo, Diego R.] Inst Brasileiro Geog & Estat, BR-30310150 Belo Horizonte, MG, Brazil.
[Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97331 USA.
[Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Kaufmann, Philip R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Oliveira, Leandro G.] Univ Fed Goias, Inst Ciencias Biol, Dept Ecol, BR-74001970 Goiania, Go, Brazil.
RP Ferreira, WR (reprint author), Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Lab Ecol Bentos, Av Antonio Carlos 6627,CP 486, BR-31270901 Belo Horizonte, MG, Brazil.
EM ferreirawr@gmail.com
RI Ligeiro, Raphael/K-7791-2015; Callisto, Marcos/O-4930-2015; Macedo,
Diego/G-2506-2015
OI Ligeiro, Raphael/0000-0001-9717-5461; Callisto,
Marcos/0000-0003-2341-4700; Macedo, Diego/0000-0002-1178-4969
FU CNPq [471385/2011-5, 302960/2011-2]; FAPEMIG [PPM-00077/13]
FX We are grateful to the Peixe-Vivo Program of Companhia Energetica de
Minas Gerais, Pesquisa & Desenvolvimento/Agencia Nacional de Energia
Eletrica/Companhia Energetica de Minas Gerais-P&D ANEEL/CEMIG (GT-487),
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Conselho
Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Fundacao de
Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), and
Fulbright-Brasil for financial support; Carlos Bernardo Mascarenhas
Alves for logistical support; colleagues from the Federal University of
Minas Gerais Benthic Ecology Laboratory, Federal Center of Technological
Education of Minas Gerais, Federal University of Lavras, and Pontifical
Catholic University of Minas Gerais for help with field collections; and
researchers at the U.S. EPA Western Ecology Division, Corvallis, Oregon
for discussions during an October 2011 workshop. MC received CNPq
research grant and research fellowship nos. 471385/2011-5 and
302960/2011-2 and FAPEMIG research grant PPM-00077/13. Tony Olsen, Marc
Weber, and Phil Larsen of the Corvallis US Environmental Protection
Agency Laboratory (Oregon, USA) kindly assisted in developing spatial
sampling designs and selecting wadeable stream sample sites. The
manuscript was improved via reviews by William Gerth of Oregon State
University, and four anonymous referees. This manuscript was subjected
to review by the US EPA National Health and Environmental Effects
Research Laboratory's Western Ecology Division and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 63
TC 1
Z9 2
U1 1
U2 7
PU EDP SCIENCES S A
PI LES ULIS CEDEX A
PA 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A,
FRANCE
SN 0003-4088
EI 2100-000X
J9 ANN LIMNOL-INT J LIM
JI Ann. Limnol.-Int. J. Limnol.
PY 2015
VL 51
IS 2
BP 115
EP 124
DI 10.1051/limn/2015004
PG 10
WC Limnology
SC Marine & Freshwater Biology
GA CJ5VX
UT WOS:000355561500003
ER
PT J
AU Hayes, PL
Carlton, AG
Baker, KR
Ahmadov, R
Washenfelder, RA
Alvarez, S
Rappengluck, B
Gilman, JB
Kuster, WC
de Gouw, JA
Zotter, P
Prevot, ASH
Szidat, S
Kleindienst, TE
Offenberg, JH
Ma, PK
Jimenez, JL
AF Hayes, P. L.
Carlton, A. G.
Baker, K. R.
Ahmadov, R.
Washenfelder, R. A.
Alvarez, S.
Rappenglueck, B.
Gilman, J. B.
Kuster, W. C.
de Gouw, J. A.
Zotter, P.
Prevot, A. S. H.
Szidat, S.
Kleindienst, T. E.
Offenberg, J. H.
Ma, P. K.
Jimenez, J. L.
TI Modeling the formation and aging of secondary organic aerosols in Los
Angeles during CalNex 2010
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID VOLATILITY BASIS-SET; AIR-POLLUTION SOURCES; MASS-SPECTROMETRY;
MEXICO-CITY; SOURCE APPORTIONMENT; TRACER COMPOUNDS; ELEMENTAL RATIO;
UNITED-STATES; AQUEOUS-PHASE; SOA FORMATION
AB Four different literature parameterizations for the formation and evolution of urban secondary organic aerosol (SOA) frequently used in 3-D models are evaluated using a 0-D box model representing the Los Angeles metropolitan region during the California Research at the Nexus of Air Quality and Climate Change (CalNex) 2010 campaign. We constrain the model predictions with measurements from several platforms and compare predictions with particle-and gas-phase observations from the CalNex Pasadena ground site. That site provides a unique opportunity to study aerosol formation close to anthropogenic emission sources with limited recirculation. The model SOA that formed only from the oxidation of VOCs (V-SOA) is insufficient to explain the observed SOA concentrations, even when using SOA parameterizations with multi-generation oxidation that produce much higher yields than have been observed in chamber experiments, or when increasing yields to their upper limit estimates accounting for recently reported losses of vapors to chamber walls. The Community Multiscale Air Quality (WRF-CMAQ) model (version 5.0.1) provides excellent predictions of secondary inorganic particle species but underestimates the observed SOA mass by a factor of 25 when an older VOC-only parameterization is used, which is consistent with many previous model-measurement comparisons for pre-2007 anthropogenic SOA modules in urban areas.
Including SOA from primary semi-volatile and intermediate-volatility organic compounds (P-S/IVOCs) following the parameterizations of Robinson et al. (2007), Grieshop et al. (2009), or Pye and Seinfeld (2010) improves model-measurement agreement for mass concentration. The results from the three parameterizations show large differences (e.g., a factor of 3 in SOA mass) and are not well constrained, underscoring the current uncertainties in this area. Our results strongly suggest that other precursors besides VOCs, such as P-S/IVOCs, are needed to explain the observed SOA concentrations in Pasadena. All the recent parameterizations overpredict urban SOA formation at long photochemical ages (approximate to 3 days) compared to observations from multiple sites, which can lead to problems in regional and especially global modeling. However, reducing IVOC emissions by one-half in the model to better match recent IVOC measurements improves SOA predictions at these long photochemical ages.
Among the explicitly modeled VOCs, the precursor compounds that contribute the greatest SOA mass are methylbenzenes. Measured polycyclic aromatic hydrocarbons (naphthalenes) contribute 0.7% of the modeled SOA mass. The amounts of SOA mass from diesel vehicles, gasoline vehicles, and cooking emissions are estimated to be 16-27, 35-61, and 19-35 %, respectively, depending on the parameterization used, which is consistent with the observed fossil fraction of urban SOA, 71(+/- 3) %. The relative contribution of each source is uncertain by almost a factor of 2 depending on the parameterization used. In-basin biogenic VOCs are predicted to contribute only a few percent to SOA. A regional SOA background of approximately 2.1 mu g m(-3) is also present due to the long-distance transport of highly aged OA, likely with a substantial contribution from regional biogenic SOA. The percentage of SOA from diesel vehicle emissions is the same, within the estimated uncertainty, as reported in previous work that analyzed the weekly cycles in OA concentrations (Bahreini et al., 2012; Hayes et al., 2013). However, the modeling work presented here suggests a strong anthropogenic source of modern carbon in SOA, due to cooking emissions, which was not accounted for in those previous studies and which is higher on weekends.
Lastly, this work adapts a simple two-parameter model to predict SOA concentration and O/C from urban emissions. This model successfully predicts SOA concentration, and the optimal parameter combination is very similar to that found for Mexico City. This approach provides a computationally inexpensive method for predicting urban SOA in global and climate models. We estimate pollution SOA to account for 26 Tg yr(-1) of SOA globally, or 17% of global SOA, one-third of which is likely to be non-fossil.
C1 [Hayes, P. L.; Ahmadov, R.; Washenfelder, R. A.; Gilman, J. B.; de Gouw, J. A.; Jimenez, J. L.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Hayes, P. L.; Jimenez, J. L.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA.
[Hayes, P. L.; Ma, P. K.] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada.
[Carlton, A. G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08903 USA.
[Baker, K. R.; Kleindienst, T. E.; Offenberg, J. H.] US EPA, Res Triangle Pk, NC 27711 USA.
[Ahmadov, R.; Washenfelder, R. A.; Gilman, J. B.; Kuster, W. C.; de Gouw, J. A.] NOAA, Earth Syst Res Lab, Boulder, CO USA.
[Alvarez, S.; Rappenglueck, B.] Univ Houston, Dept Earth & Atmospher Sci, Houston, TX 77004 USA.
[Zotter, P.; Prevot, A. S. H.] Paul Scherrer Inst, Lab Atmospher Chem, Villigen, Switzerland.
[Szidat, S.] Univ Bern, Dept Chem & Biochem, Bern, Switzerland.
[Szidat, S.] Univ Bern, Oeschger Ctr Climate Change Res, Bern, Switzerland.
RP Hayes, PL (reprint author), Univ Colorado, CIRES, Boulder, CO 80309 USA.
EM patrick.hayes@umontreal.ca; jose.jimenez@colorado.edu
RI Prevot, Andre/C-6677-2008; Ahmadov, Ravan/F-2036-2011; Carlton,
Annmarie/A-7867-2011; Washenfelder, Rebecca/E-7169-2010; Jimenez,
Jose/A-5294-2008; Szidat, Sonke/D-6706-2011; Offenberg,
John/C-3787-2009; Gilman, Jessica/E-7751-2010; Kuster,
William/E-7421-2010; Manager, CSD Publications/B-2789-2015; de Gouw,
Joost/A-9675-2008
OI Prevot, Andre/0000-0002-9243-8194; Ahmadov, Ravan/0000-0002-6996-7071;
Carlton, Annmarie/0000-0002-8574-1507; Washenfelder,
Rebecca/0000-0002-8106-3702; Jimenez, Jose/0000-0001-6203-1847; Szidat,
Sonke/0000-0002-1824-6207; Offenberg, John/0000-0002-0213-4024; Gilman,
Jessica/0000-0002-7899-9948; Kuster, William/0000-0002-8788-8588; de
Gouw, Joost/0000-0002-0385-1826
FU US DOE (BER, ASR program) [DE-SC0006035, DE-SC0006711, DE-SC0011105];
NSF [AGS-1243354, AGS-1360834]; NOAA [NA13OAR4310063]; CIRES Visiting
Fellows Program; NSERC; Universite de Montreal; US Weather Research
Program within the NOAA/OAR Office of Weather and Air Quality; [CARB
08-319]; [CARB 11-305]
FX This work was partially supported by CARB 08-319 and CARB 11-305; US DOE
(BER, ASR program) DE-SC0006035, DE-SC0006711, and DE-SC0011105; NSF
AGS-1243354 and AGS-1360834; and NOAA NA13OAR4310063. P. L. Hayes is
also grateful for a fellowship from the CIRES Visiting Fellows Program,
and P. L. Hayes and P. K. Ma acknowledge support from a NSERC Discovery
Grant and the Universite de Montreal. The authors thank Chris J.
Hennigan (UMBC) and Allen L. Robinson (CMU) for providing the
naphthalene and methylnaphthalene data. We also thank John S. Holloway
(NOAA) for providing CO data, Roya Bahreini (University of
California-Riverside) and Ann M. Middlebrook (NOAA) for providing OA
data from the NOAA P3, and Stuart A. McKeen (NOAA) for helpful
discussions. R. Ahmadov is supported by the US Weather Research Program
within the NOAA/OAR Office of Weather and Air Quality. The US
Environmental Protection Agency through its Office of Research and
Development collaborated in the research described here. The manuscript
was subjected to external peer review and has been cleared for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 109
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Z9 19
U1 16
U2 89
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 10
BP 5773
EP 5801
DI 10.5194/acp-15-5773-2015
PG 29
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CJ2BM
UT WOS:000355289200028
ER
PT J
AU Guo, H
Xu, L
Bougiatioti, A
Cerully, KM
Capps, SL
Hite, JR
Carlton, AG
Lee, SH
Bergin, MH
Ng, NL
Nenes, A
Weber, RJ
AF Guo, H.
Xu, L.
Bougiatioti, A.
Cerully, K. M.
Capps, S. L.
Hite, J. R., Jr.
Carlton, A. G.
Lee, S. -H.
Bergin, M. H.
Ng, N. L.
Nenes, A.
Weber, R. J.
TI Fine-particle water and pH in the southeastern United States
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; LIQUID PHASE-SEPARATION;
THERMODYNAMIC-EQUILIBRIUM MODEL; ATMOSPHERIC PARTICLES; HYGROSCOPIC
GROWTH; RELATIVE-HUMIDITY; ALPHA-PINENE; INORGANIC AEROSOLS;
MASS-SPECTROMETER; AMMONIUM-SULFATE
AB Particle water and pH are predicted using meteorological observations (relative humidity (RH), temperature (T)), gas/particle composition, and thermodynamic modeling (ISORROPIA-II). A comprehensive uncertainty analysis is included, and the model is validated. We investigate mass concentrations of particle water and related particle pH for ambient fine-mode aerosols sampled in a relatively remote Alabama forest during the Southern Oxidant and Aerosol Study (SOAS) in summer and at various sites in the southeastern US during different seasons, as part of the Southeastern Center for Air Pollution and Epidemiology (SCAPE) study. Particle water and pH are closely linked; pH is a measure of the particle H+ aqueous concentration and depends on both the presence of ions and amount of particle liquid water. Levels of particle water, in turn, are determined through water uptake by both the ionic species and organic compounds. Thermodynamic calculations based on measured ion concentrations can predict both pH and liquid water but may be biased since contributions of organic species to liquid water are not considered. In this study, contributions of both the inorganic and organic fractions to aerosol liquid water were considered, and predictions were in good agreement with measured liquid water based on differences in ambient and dry light scattering coefficients (prediction vs. measurement: slope = 0.91, intercept = 0.5 mu gm(-3), R-2 = 0.75). ISORROPIA-II predictions were confirmed by good agreement between predicted and measured ammonia concentrations (slope = 1.07, intercept = -0.12 mu gm(-3), R-2 = 0.76). Based on this study, organic species on average contributed 35% to the total water, with a substantially higher contribution (50 %) at night. However, not including contributions of organic water had a minor effect on pH (changes pH by 0.15 to 0.23 units), suggesting that predicted pH without consideration of organic water could be sufficient for the purposes of aqueous secondary organic aerosol (SOA) chemistry. The mean pH predicted in the Alabama forest (SOAS) was 0.94 +/- 0.59 (median 0.93). pH diurnal trends followed liquid water and were driven mainly by variability in RH; during SOAS nighttime pH was near 1.5, while daytime pH was near 0.5. pH ranged from 0.5 to 2 in summer and 1 to 3 in the winter at other sites. The systematically low pH levels in the southeast may have important ramifications, such as significantly influencing acid-catalyzed reactions, gas-aerosol partitioning, and mobilization of redox metals and minerals. Particle ion balances or molar ratios, often used to infer pH, do not consider the dissociation state of individual ions or particle liquid water levels and do not correlate with particle pH.
C1 [Guo, H.; Hite, J. R., Jr.; Bergin, M. H.; Ng, N. L.; Nenes, A.; Weber, R. J.] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Xu, L.; Bougiatioti, A.; Cerully, K. M.; Ng, N. L.; Nenes, A.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.
[Bergin, M. H.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Capps, S. L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Carlton, A. G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08903 USA.
[Lee, S. -H.] Kent State Univ, Coll Publ Hlth, Kent, OH 44242 USA.
[Nenes, A.] Fdn Res & Technol, Hellas, Greece.
[Bougiatioti, A.] Natl Tech Univ Athens, Athens, Greece.
RP Weber, RJ (reprint author), Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
EM athanasios.nenes@gatech.edu; rodney.weber@eas.gatech.edu
RI Carlton, Annmarie/A-7867-2011; Capps, Shannon/E-5602-2017
OI Carlton, Annmarie/0000-0002-8574-1507; Capps,
Shannon/0000-0002-6872-6604
FU NSF as part of the SOAS campaign [1242258]; US EPA STAR [R835410]; NOAA
CPO [NA10OAR4310102]; EPA through US EPA [R834799]; Research
Participation Program at the Office of Research and Development, US EPA;
Georgia Power Faculty Scholar Chair; Georgia Institute of Technology;
NSF [AGS-1241498]; Operational Program "Education and Lifelong Learning"
(Action's Beneficiary: General Secretariat for Research and Technology);
European Social Fund (ESF); Greek state
FX This work was supported by the NSF under grant number 1242258 as part of
the SOAS campaign. GIT SOAS researchers were also supported by a US EPA
STAR grant R835410 and NOAA CPO Award NA10OAR4310102. Measurements at
other sites in the southeast were part of the EPA-supported SCAPE Clean
Air Center, made possible through US EPA grant R834799. The content of
this publication are solely the responsibility of the grantee and do not
necessarily represent the official views of the US EPA. Further, the US
EPA does not endorse the purchase of any commercial products or services
mentioned in the publication. S. L. Capps was supported by an
appointment to the Research Participation Program at the Office of
Research and Development, US EPA, administered by ORISE. A. Nenes
acknowledges support from a Georgia Power Faculty Scholar Chair and a
Cullen-Peck Faculty Fellowship from the Georgia Institute of Technology.
We would also like to thank Richard Moore from NASA Langley for valuable
suggestions and discussions. S.-H. Lee acknowledges funding support from
NSF (AGS-1241498). A. Bougiatioti acknowledges support within the
framework of the Action Supporting Postdoctoral Researchers of the
Operational Program "Education and Lifelong Learning" (Action's
Beneficiary: General Secretariat for Research and Technology) and is
co-financed by the European Social Fund (ESF) and the Greek state. We
wish to thank the Southeastern Aerosol Research and Characterization
(SEARCH) personnel for their many contributions supporting the field
deployments.
NR 82
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Z9 41
U1 25
U2 86
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 9
BP 5211
EP 5228
DI 10.5194/acp-15-5211-2015
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CJ2BL
UT WOS:000355289100015
ER
PT J
AU Baker, KR
Carlton, AG
Kleindienst, TE
Offenberg, JH
Beaver, MR
Gentner, DR
Goldstein, AH
Hayes, PL
Jimenez, JL
Gilman, JB
de Gouw, JA
Woody, MC
Pye, HOT
Kelly, JT
Lewandowski, M
Jaoui, M
Stevens, PS
Brune, WH
Lin, YH
Rubitschun, CL
Surratt, JD
AF Baker, K. R.
Carlton, A. G.
Kleindienst, T. E.
Offenberg, J. H.
Beaver, M. R.
Gentner, D. R.
Goldstein, A. H.
Hayes, P. L.
Jimenez, J. L.
Gilman, J. B.
de Gouw, J. A.
Woody, M. C.
Pye, H. O. T.
Kelly, J. T.
Lewandowski, M.
Jaoui, M.
Stevens, P. S.
Brune, W. H.
Lin, Y. -H.
Rubitschun, C. L.
Surratt, J. D.
TI Gas and aerosol carbon in California: comparison of measurements and
model predictions in Pasadena and Bakersfield
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; SAN-JOAQUIN VALLEY; LOS-ANGELES BASIN;
AIR-QUALITY; UNITED-STATES; SOA FORMATION; AGRICULTURAL CROPS;
OXALIC-ACID; 2010 CALNEX; EMISSIONS
AB Co-located measurements of fine particulate matter (PM2.5 /organic carbon (OC), elemental carbon, radiocarbon (C-14), speciated volatile organic compounds (VOCs), and OH radicals during the CalNex field campaign provide a unique opportunity to evaluate the Community Multi-scale Air Quality (CMAQ) model's representation of organic species from VOCs to particles. Episode average daily 23 h average C-14 analysis indicates PM2.5 carbon at Pasadena and Bakersfield during the CalNex field campaign was evenly split between contemporary and fossil origins. CMAQ predicts a higher contemporary carbon fraction than indicated by the C-14 analysis at both locations. The model underestimates measured PM2.5 organic carbon at both sites with very little (7% in Pasadena) of the modeled mass represented by secondary production, which contrasts with the ambient-based SOC / OC fraction of 63% at Pasadena.
Measurements and predictions of gas-phase anthropogenic species, such as toluene and xylenes, are generally within a factor of 2, but the corresponding SOC tracer (2,3-dihydroxy-4-oxo-pentanoic acid) is systematically underpredicted by more than a factor of 2. Monoterpene VOCs and SOCs are underestimated at both sites. Isoprene is underestimated at Pasadena and overpredicted at Bakersfield and isoprene SOC mass is underestimated at both sites. Systematic model underestimates in SOC mass coupled with reasonable skill (typically within a factor of 2) in predicting hydroxyl radical and VOC gas-phase precursors suggest error( s) in the parameterization of semivolatile gases to form SOC. Yield values (alpha) applied to semivolatile partitioning species were increased by a factor of 4 in CMAQ for a sensitivity simulation, taking into account recent findings of underestimated yields in chamber experiments due to gas wall losses. This sensitivity resulted in improved model performance for PM2.5 organic carbon at both field study locations and at routine monitor network sites in California. Modeled percent secondary contribution (22% at Pasadena) becomes closer to ambient-based estimates but still contains a higher primary fraction than observed.
C1 [Baker, K. R.; Kelly, J. T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Carlton, A. G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08903 USA.
[Kleindienst, T. E.; Offenberg, J. H.; Beaver, M. R.; Woody, M. C.; Pye, H. O. T.; Lewandowski, M.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Gentner, D. R.] Yale Univ, Dept Chem & Environm Engn, New Haven, CT USA.
[Goldstein, A. H.] Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA.
[Hayes, P. L.] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada.
[Jimenez, J. L.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA.
[Jimenez, J. L.] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Gilman, J. B.; de Gouw, J. A.] Natl Ocean & Atmospher Adm, Chem Sci Div, Earth Syst Res Lab, Boulder, CO USA.
[Jaoui, M.] Alion Sci & Technol Inc, Res Triangle Pk, NC USA.
[Stevens, P. S.] Indiana Univ, Sch Publ & Environm Affairs, Ctr Res Environm Sci, Bloomington, IN USA.
[Stevens, P. S.] Indiana Univ, Dept Chem, Bloomington, IN USA.
[Brune, W. H.] Penn State Univ, Dept Meteorol, University Pk, PA 16802 USA.
[Lin, Y. -H.; Rubitschun, C. L.; Surratt, J. D.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
RP Baker, KR (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM baker.kirk@epa.gov
RI Kelly, James/F-8135-2010; Carlton, Annmarie/A-7867-2011; de Gouw,
Joost/A-9675-2008; Jimenez, Jose/A-5294-2008; Surratt,
Jason/D-3611-2009; Offenberg, John/C-3787-2009; Lin,
Ying-Hsuan/J-4023-2014; Gilman, Jessica/E-7751-2010; Pye,
Havala/F-5392-2012; Manager, CSD Publications/B-2789-2015
OI Kelly, James/0000-0001-6574-5714; Carlton, Annmarie/0000-0002-8574-1507;
de Gouw, Joost/0000-0002-0385-1826; Jimenez, Jose/0000-0001-6203-1847;
Surratt, Jason/0000-0002-6833-1450; Offenberg, John/0000-0002-0213-4024;
Lin, Ying-Hsuan/0000-0001-8904-1287; Gilman,
Jessica/0000-0002-7899-9948; Pye, Havala/0000-0002-2014-2140;
FU EPA, through its Office of Research and Development [EP-D-10-070]; EPA's
STAR program [RD83504101]; CARB [11-305]
FX The authors would like to acknowledge measurements taken by Scott
Scheller and the contribution from Chris Misenis, Allan Beidler, Chris
Allen, James Beidler, Heather Simon, and Rich Mason. EPA, through its
Office of Research and Development, funded and collaborated in the
research described here under contract EP-D-10-070 to Alion Science and
Technology. This work is supported in part through EPA's STAR program,
grant number RD83504101. P. L. Hayes and J. L. Jimenez were supported by
CARB 11-305.
NR 77
TC 9
Z9 9
U1 6
U2 51
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 9
BP 5243
EP 5258
DI 10.5194/acp-15-5243-2015
PG 16
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CJ2BL
UT WOS:000355289100017
ER
PT J
AU DeVito, SC
Keenan, C
Lazarus, D
AF DeVito, Stephen C.
Keenan, Cheryl
Lazarus, Dana
TI Can pollutant release and transfer registers (PRTRs) be used to assess
implementation and effectiveness of green chemistry practices? A case
study involving the Toxics Release Inventory (TRI) and pharmaceutical
manufacturers
SO GREEN CHEMISTRY
LA English
DT Article
AB Pharmaceutical firms have reported that implementation of green chemistry practices in their manufacturing processes have significantly reduced the quantities of toxic chemicals they use, release to the environment, or otherwise manage as waste. Using the United States Environmental Protection Agency's (EPA's) Toxics Release Inventory (TRI) database and literature publications, we conducted research to assess this claim. Our analyses show that over the 2002 through 2011 timeframe the quantities of toxic chemicals reported annually by pharmaceutical manufacturing facilities to EPA's TRI Program as released to the environment or otherwise managed as waste have declined steadily and by more than 60%. The large reductions in the reported quantities are sector-wide, and it appears that factors such as outsourcing, production levels, regulations, shifts to other waste management practices, or TRI reporting characteristics by the larger pharmaceutical firms are not driving the decline. Our analyses, combined with the extensive evidence in the literature of green chemistry advances within the pharma sector, lead us to conclude that implementation of green chemistry practices is a major contributing factor to the large reductions we report herein. We believe the TRI, an easy-to-use pollution prevention tool used extensively for tracking environmental performance, is uniquely well-suited for assessing the progress made by different industry sectors or specific facilities therein in implementing green chemistry practices and the effectiveness that such practices have in preventing pollution: uses of the TRI that hitherto have not been reported. Moreover, our findings indicate that other pollutant release and transfer registers (PRTRs) may have the potential to be used for these purposes as well.
C1 [DeVito, Stephen C.] US EPA, Tox Release Inventory Program, Washington, DC 20460 USA.
[Keenan, Cheryl; Lazarus, Dana] Abt Associates Inc, Cambridge, MA 02138 USA.
RP DeVito, SC (reprint author), US EPA, Tox Release Inventory Program, Mail Code 2844 T, Washington, DC 20460 USA.
EM devito.steve@epa.gov
NR 34
TC 2
Z9 2
U1 3
U2 7
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PY 2015
VL 17
IS 5
BP 2679
EP 2692
DI 10.1039/c5gc00056d
PG 14
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA CI0EQ
UT WOS:000354409500006
ER
PT J
AU Cinelli, M
Coles, SR
Nadagouda, MN
Blaszczynski, J
Slowinski, R
Varma, RS
Kirwan, K
AF Cinelli, Marco
Coles, Stuart R.
Nadagouda, Mallikarjuna N.
Blaszczynski, Jerzy
Slowinski, Roman
Varma, Rajender S.
Kirwan, Kerry
TI A green chemistry-based classification model for the synthesis of silver
nanoparticles
SO GREEN CHEMISTRY
LA English
DT Article
ID LIFE-CYCLE ASSESSMENT; CRITERIA DECISION-ANALYSIS; ROUGH SET APPROACH;
MICROWAVE-ASSISTED SYNTHESIS; EX ANTE ASSESSMENT; METAL NANOPARTICLES;
ANTIBACTERIAL ACTIVITY; MULTICRITERIA CLASSIFICATION;
SONOELECTROCHEMICAL METHODS; CROPPING SYSTEMS
AB The assessment of the implementation of green chemistry principles in the syntheses of nanomaterials is a complex decision-making problem that necessitates the integration of several evaluation criteria. Multiple Criteria Decision Aiding (MCDA) provides support for such a challenge. One of its methods - Dominance-based Rough Set Approach (DRSA) - was used in this research to develop a model for the green chemistry-based classification of silver nanoparticle synthesis protocols into preference-ordered performance classes. DRSA allowed integration of knowledge from both peer-reviewed literature and experts (decision makers, DMs) in the field, resulting in a model composed of decision rules that are logical statements in the form: "if conditions, then decision". The approach provides the basis for the design of rules for the greener synthesis of silver nanoparticles. Decision rules are supported by synthesis protocols that enforce the principles of green chemistry to various extents, resulting in robust recommendations for the development and assessment of silver nanoparticle synthesis that perform at one of five pre-determined levels. The DRSA-based approach is transparent and structured and can be easily updated. New perspectives and criteria could be added into the model if relevant data were available and domain-specific experts could collaborate through the MCDA procedure.
C1 [Cinelli, Marco; Coles, Stuart R.; Kirwan, Kerry] Univ Warwick, Int Mfg Ctr, WMG, Coventry CV4 7AL, W Midlands, England.
[Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, NRMRL,ORD, Cincinnati, OH 45268 USA.
[Blaszczynski, Jerzy; Slowinski, Roman] Poznan Univ Tech, Inst Comp Sci, PL-60965 Poznan, Poland.
[Slowinski, Roman] Polish Acad Sci, Syst Res Inst, PL-01447 Warsaw, Poland.
[Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
RP Cinelli, M (reprint author), Univ Warwick, Int Mfg Ctr, WMG, Univ Rd, Coventry CV4 7AL, W Midlands, England.
EM m.cinelli@warwick.ac.uk; Varma.rajender@epa.gov;
kerry.kirwan@warwick.ac.uk
RI Slowinski, Roman/A-5751-2013; Blaszczynski, Jerzy/M-1601-2014;
OI Slowinski, Roman/0000-0002-5200-7795; Cinelli, Marco/0000-0001-5822-3627
FU UK Engineering and Physical Sciences Research Council; WMG Department of
the University of Warwick (UK); "CL4W", Cleaning Land for Wealth
[EP/K026216/1]
FX The authors greatly acknowledge the funding from the UK Engineering and
Physical Sciences Research Council, WMG Department of the University of
Warwick (UK) and the "CL4W", Cleaning Land for Wealth, project (grant
number EP/K026216/1). The authors would like to thank Dr David E. Meyer,
Dr Michael Gonzalez and Dr Gerardo Ruiz-Mercado from U.S. EPA for the
thorough and constructive feedback provided during the paper
development.
NR 121
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U2 24
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PY 2015
VL 17
IS 5
BP 2825
EP 2839
DI 10.1039/c4gc02088j
PG 15
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA CI0EQ
UT WOS:000354409500027
ER
PT J
AU Chern, EC
King, D
Haugland, R
Pfaller, S
AF Chern, Eunice C.
King, Dawn
Haugland, Richard
Pfaller, Stacy
TI Evaluation of quantitative polymerase chain reaction assays targeting
Mycobacterium avium, M. intracellulare, and M. avium subspecies
paratuberculosis in drinking water biofilms
SO JOURNAL OF WATER AND HEALTH
LA English
DT Article
DE biofilm; M. avium; M. avium subsp paratuberculosis; M. intracellulare;
qPCR
ID REAL-TIME PCR; NONTUBERCULOUS MYCOBACTERIA; ENVIRONMENTAL MYCOBACTERIA;
DISTRIBUTION-SYSTEMS; POTABLE WATER; COMPLEX; INFECTION; SAMPLES;
QUANTIFICATION; IDENTIFICATION
AB Mycobacterium avium (MA), Mycobacterium intracellulare (MI), and Mycobacterium avium subsp. paratuberculosis (MAP) are difficult to culture due to their slow growing nature. A quantitative polymerase chain reaction (qPCR) method for the rapid detection of MA, MI, and MAP can be used to provide data supporting drinking water biofilms as potential sources of human exposure. The aim of this study was to characterize two qPCR assays targeting partial 16S rRNA gene sequences of MA and MI and use these assays, along with two previously reported MAP qPCR assays (IS900 and Target 251), to investigate Mycobacterium occurrence in kitchen faucet biofilms. MA and MI qPCR assays demonstrated 100% specificity and sensitivity when evaluated against 18 non-MA complex, 76 MA, and 17 MI isolates. Both assays detected approximately 1,000 cells from a diluted cell stock inoculated on a sampling swab 100% of the time. DNA analysis by qPCR indicated that 35.3, 56.9 and 11.8% of the 51 kitchen faucet biofilm samples collected contained MA, MI, and MAP, respectively. This study introduces novel qPCR assays designed to specifically detect MA and MI in biofilm. Results support the use of qPCR as an alternative to culture for detection and enumeration of MA, MI, and MAP in microbiologically complex samples.
C1 [Chern, Eunice C.; King, Dawn; Haugland, Richard; Pfaller, Stacy] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Pfaller, S (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM pfaller.stacy@epa.gov
FU US EPA, ORD
FX The authors wish to thank all individuals that provided samples for this
study. The views expressed in this article are those of the authors and
do not necessarily represent the views or policies of the US
Environmental Protection Agency. Mention of trade names, products or
services does not convey official EPA approval, endorsement, or
recommendation. This project was supported in part by an appointment to
the Research Participation Program for the US EPA, ORD, administered by
the Oak Ridge Institute for Science and Education through an interagency
agreement between the US DOE and the EPA.
NR 37
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U1 6
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1477-8920
J9 J WATER HEALTH
JI J. Water Health
PY 2015
VL 13
IS 1
BP 131
EP 139
DI 10.2166/wh.2014.060
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Microbiology; Water Resources
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Microbiology; Water Resources
GA CJ0QY
UT WOS:000355183800013
PM 25719473
ER
PT J
AU Gomez-Alvarez, V
Humrighouse, BW
Revetta, RP
Domingo, JWS
AF Gomez-Alvarez, Vicente
Humrighouse, Ben W.
Revetta, Randy P.
Domingo, Jorge W. Santo
TI Bacterial composition in a metropolitan drinking water distribution
system utilizing different source waters
SO JOURNAL OF WATER AND HEALTH
LA English
DT Article
DE bacterial diversity; drinking water bacteria; 16S rRNA gene sequencing
ID COMMUNITY STRUCTURE; BIOFILMS; MYCOBACTERIA; ECOLOGY; CHLORINATION;
DIVERSITY; PROTOZOA; RNA
AB We investigated the bacterial composition of water samples from two service areas within a drinking water distribution system (DWDS), each associated with a different primary source of water (groundwater, GW; surface water, SW) and different treatment process. Community analysis based on 16S rRNA gene clone libraries indicated that Actinobacteria (Mycobacterium spp.) and alpha-Proteobacteria represented nearly 43 and 38% of the total sequences, respectively. Sequences closely related to Legionella, Pseudomonas, and Vibrio spp. were also identified. In spite of the high number of sequences (71%) shared in both areas, multivariable analysis revealed significant differences between the GW and SW areas. While the dominant phylotypes where not significantly contributing in the ordination of samples, the populations associated with the core of phylotypes (1-10% in each sample) significantly contributed to the differences between both service areas. Diversity indices indicate that the microbial community inhabiting the SW area is more diverse and contains more distantly related species coexisting with local assemblages as compared with the GW area. The bacterial community structure of SW and GW service areas were dissimilar, suggesting that their respective source water and/or water quality parameters shaped by the treatment processes may contribute to the differences in community structure observed.
C1 [Gomez-Alvarez, Vicente; Revetta, Randy P.; Domingo, Jorge W. Santo] US EPA, Cincinnati, OH 45268 USA.
[Humrighouse, Ben W.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH USA.
[Humrighouse, Ben W.] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Domingo, JWS (reprint author), US EPA, Cincinnati, OH 45268 USA.
EM santodomingo.jorge@epa.gov
FU US Environmental Protection Agency
FX This work was funded by a Traineeship Award from the US Environmental
Protection Agency to BWH. Special thanks to Jeff Swertfeger from the
Greater Cincinnati Water Work (GCWW) for helping in the logistics of the
water collection, to the Greater Cincinnati Water Work personnel for
helping in the water collection and Margaret Kupferle and Daniel Oerther
for revising initial drafts of this manuscript. The opinions expressed
in this paper are those of the authors, and do not necessarily reflect
the official positions and policies of the US Environmental Protection
Agency. Any mention of product or trade names does not constitute
recommendation for use by the US Environmental Protection Agency.
NR 37
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1477-8920
J9 J WATER HEALTH
JI J. Water Health
PY 2015
VL 13
IS 1
BP 140
EP 151
DI 10.2166/wh.2014.057
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
Microbiology; Water Resources
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Microbiology; Water Resources
GA CJ0QY
UT WOS:000355183800014
PM 25719474
ER
PT J
AU Rahman, L
Shah, A
Lunsford, SK
Han, C
Nadagouda, MN
Sahle-Demessie, E
Qureshi, R
Khan, MS
Kraatz, HB
Dionysiou, DD
AF Rahman, Latif-ur
Shah, Afzal
Lunsford, Suzanne Kay
Han, Changseok
Nadagouda, Mallikarjuna N.
Sahle-Demessie, Endalkachew
Qureshi, Rumana
Khan, Muhammad Saleem
Kraatz, Heinz-Bernhard
Dionysiou, Dionysios. D.
TI Monitoring of 2-butanone using a Ag-Cu bimetallic alloy nanoscale
electrochemical sensor
SO RSC ADVANCES
LA English
DT Article
ID AU-AG; DNA HYBRIDIZATION; NANOPARTICLES; OXIDATION
AB Spherical shaped silver-copper alloy nanoparticles of 10-15 nm size were synthesized by an aqueous polymer solution method. The synthesized nanoscale Ag-Cu alloy was characterized by UV-Visible spectroscopy, X-ray diffraction spectroscopy, transmission electron microscopy (TEM), high resolution TEM, and energy dispersive spectroscopy. The XRD pattern showed high crystallinity and phase formation of the nanoparticles. The bimetallic alloy nanoparticles were coated over a well-polished glassy carbon electrode and the designed sensor was applied for the detection of a highly carcinogenic carbonyl compound, 2-butanone. Electrochemical studies revealed that PEI used as a capping agent also enhances the sensing of the modified electrode for the recognition of 2-butanone. The sensor developed from Ag-Cu (1 : 1) alloy nanoparticles showed the best sensing properties for the detection of 2-butanone as evidenced by electrochemical impedance spectroscopy and a 0.1 mu M detection limit.
C1 [Rahman, Latif-ur; Shah, Afzal; Qureshi, Rumana] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
[Rahman, Latif-ur; Han, Changseok; Dionysiou, Dionysios. D.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
[Kraatz, Heinz-Bernhard] Univ Toronto, Dept Phys & Environm Sci, Toronto, ON M1C 1A4, Canada.
[Lunsford, Suzanne Kay] Wright State Univ, Dept Chem, Dayton, OH 45435 USA.
[Han, Changseok; Nadagouda, Mallikarjuna N.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Water Qual Management Branch, Cincinnati, OH 45268 USA.
[Sahle-Demessie, Endalkachew] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
[Khan, Muhammad Saleem] Univ Peshawar, Natl Ctr Excellence Phys Chem, Khyber Pakhtunkhwa, Pakistan.
RP Shah, A (reprint author), Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
EM afzal.shah@utoronto.ca; dionysios.d.dionysiou@uc.edu
RI Shah, Afzal/J-2242-2015;
OI Kraatz, Bernie/0000-0002-7149-0110
FU Chemistry Department of Quaid-i-Azam University, Islamabad, Pakistan;
Department of Physical and Environmental Sciences, University of
Toronto, Canada; Department of Biomedical, Chemical and Environmental
Engineering (DBCEE), University of Cincinnati, Cincinnati, Ohio, USA;
Higher Education Commission of Pakistan
FX This work was jointly supported by the Chemistry Department of
Quaid-i-Azam University, Islamabad, Pakistan, Department of Physical and
Environmental Sciences, University of Toronto, Canada and Department of
Biomedical, Chemical and Environmental Engineering (DBCEE), University
of Cincinnati, Cincinnati, Ohio, USA. The financial support of Higher
Education Commission of Pakistan is also acknowledged.
NR 32
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U2 17
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2015
VL 5
IS 55
BP 44427
EP 44434
DI 10.1039/c5ra03633j
PG 8
WC Chemistry, Multidisciplinary
SC Chemistry
GA CI7SM
UT WOS:000354964900063
ER
PT S
AU Brown-Peterson, NJ
Brewton, RA
Griffitt, RJ
Fulford, RS
AF Brown-Peterson, Nancy J.
Brewton, Rachel A.
Griffitt, Robert J.
Fulford, Richard S.
BE Alford, JB
Peterson, MS
Green, CC
TI Impacts of the Deepwater Horizon Oil Spill on the Reproductive Biology
of Spotted Seatrout (Cynoscion nebulosus)
SO IMPACTS OF OIL SPILL DISASTERS ON MARINE HABITATS AND FISHERIES IN NORTH
AMERICA
SE CRC Marine Biology Series
LA English
DT Article; Book Chapter
ID GULF-OF-MEXICO; LOUISIANA SALT MARSHES; FISH; ESTUARIES; GROWTH
C1 [Brown-Peterson, Nancy J.; Griffitt, Robert J.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA.
[Brewton, Rachel A.] Texas A&M Univ Corpus Christi, Harte Res Inst Gulf Mexico Studies, Corpus Christi, TX USA.
[Fulford, Richard S.] US EPA, Ecosyst Assessment Branch, Gulf Breeze, FL USA.
RP Brown-Peterson, NJ (reprint author), Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA.
NR 27
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U1 2
U2 7
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
SN 2154-7769
BN 978-1-4665-5721-5; 978-1-4665-5720-8
J9 CRC MAR BIOL SER
JI CRC Mar. Biol. Ser.
PY 2015
BP 237
EP 252
PG 16
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA BC7CH
UT WOS:000354736900013
ER
PT S
AU Fulford, RS
Griffit, RJ
Brown-Peterson, NJ
Perry, H
Sanchez-Rubio, G
AF Fulford, Richard S.
Griffit, Robert J.
Brown-Peterson, Nancy J.
Perry, Harriet
Sanchez-Rubio, Guillermo
BE Alford, JB
Peterson, MS
Green, CC
TI Impacts of the Deepwater Horizon Oil Spill on Blue Crab, Callinectes
sapidus, Larval Settlement in Mississippi
SO IMPACTS OF OIL SPILL DISASTERS ON MARINE HABITATS AND FISHERIES IN NORTH
AMERICA
SE CRC Marine Biology Series
LA English
DT Article; Book Chapter
ID PRINCE-WILLIAM-SOUND; GULF-OF-MEXICO; CHESAPEAKE BAY; ALASKA; ABUNDANCE;
USA; VARIABILITY; RECRUITMENT; ENVIRONMENT; DISPERSION
C1 [Fulford, Richard S.] US EPA, Ecosyst Assessment Branch, Gulf Breeze, FL 32561 USA.
[Griffit, Robert J.; Brown-Peterson, Nancy J.; Perry, Harriet] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS USA.
[Sanchez-Rubio, Guillermo] Ctr Fisheries Res & Dev, Gulf Coast Res Lab, Ocean Springs, MS USA.
RP Fulford, RS (reprint author), US EPA, Ecosyst Assessment Branch, Gulf Breeze, FL 32561 USA.
NR 35
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U1 1
U2 7
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
SN 2154-7769
BN 978-1-4665-5721-5; 978-1-4665-5720-8
J9 CRC MAR BIOL SER
JI CRC Mar. Biol. Ser.
PY 2015
BP 253
EP 267
PG 15
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA BC7CH
UT WOS:000354736900014
ER
PT J
AU Duckworth, K
Spencer, M
Bates, C
Miller, ME
Almquist, C
Grimaila, M
Magnuson, M
Willison, S
Phillips, R
Racz, L
AF Duckworth, Kelsey
Spencer, Michael
Bates, Christopher
Miller, Michael E.
Almquist, Catherine
Grimaila, Michael
Magnuson, Matthew
Willison, Stuart
Phillips, Rebecca
Racz, LeeAnn
TI Advanced oxidation degradation kinetics as a function of ultraviolet LED
duty cycle
SO WATER SCIENCE AND TECHNOLOGY
LA English
DT Article
DE hydrogen peroxide; light emitting diode; methylene blue; ultraviolet
ID LIGHT EMITTING DIODES; AQUEOUS-SOLUTION; UV; EFFICIENCY; ILLUMINATION;
PHENOL
AB Ultraviolet (UV) light emitting diodes (LEDs) may be a viable option as a UV light source for advanced oxidation processes (AOPs) utilizing photocatalysts or oxidizing agents such as hydrogen peroxide. The effect of UV-LED duty cycle, expressed as the percentage of time the LED is powered, was investigated in an AOP with hydrogen peroxide, using methylene blue (MB) to assess contaminant degradation. The UV-LED AOP degraded the MB at all duty cycles. However, adsorption of MB onto the LED emitting surface caused a linear decline in reactor performance over time. With regard to the effect of duty cycle, the observed rate constant of MB degradation, after being adjusted to account for the duty cycle, was greater for 5 and 10% duty cycles than higher duty cycles, providing a value approximately 160% higher at 5% duty cycle than continuous operation. This increase in adjusted rate constant at low duty cycles, as well as contaminant fouling of the LED surface, may impact design and operational considerations for pulsed UV-LED AOP systems.
C1 [Duckworth, Kelsey; Spencer, Michael; Bates, Christopher; Miller, Michael E.; Grimaila, Michael; Racz, LeeAnn] Air Force Inst Technol, Dept Syst Engn & Management, Wright Patterson AFB, OH 45433 USA.
[Almquist, Catherine] Miami Univ, Chem Paper & Biomed Engn Dept, Oxford, OH 45056 USA.
[Magnuson, Matthew; Willison, Stuart] US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, Cincinnati, OH 45268 USA.
[Phillips, Rebecca] US EPA, Oak Ridge Inst Sci & Educ, Cincinnati, OH 45268 USA.
RP Miller, ME (reprint author), Air Force Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA.
EM michael.miller@afit.edu
FU US Environmental Protection Agency through Office of Research and
Development [92370201]; appointment to the Internship/Research
Participation Program at the National Homeland Security Research Center,
Water Infrastructure Protection Division, US Environmental Protection
Agency
FX The US Environmental Protection Agency through its Office of Research
and Development partially funded and collaborated in the research
described here under Interagency Agreement 92370201. It has been
subjected to the Agency's review and approved for publication. Approval
does not signify that the contents necessarily reflect the views of the
Agency. Mention of trade names, products, or services does not convey
official EPA approval, endorsement, or recommendation. This project was
supported in part by an appointment to the Internship/Research
Participation Program at the National Homeland Security Research Center,
Water Infrastructure Protection Division, US Environmental Protection
Agency, administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the US Department of
Energy and EPA. The authors would like to acknowledge the support of
Sarah Fyda, Nate Godby and Robert Scott for collecting a portion of the
experimental data.
NR 19
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0273-1223
EI 1996-9732
J9 WATER SCI TECHNOL
JI Water Sci. Technol.
PY 2015
VL 71
IS 9
BP 1375
EP 1381
DI 10.2166/wst.2015.108
PG 7
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA CI4NF
UT WOS:000354726000014
PM 25945855
ER
PT J
AU McAlary, T
Groenevelt, H
Disher, S
Arnold, J
Seethapathy, S
Sacco, P
Crump, D
Schumacher, B
Hayes, H
Johnson, P
Gorecki, T
AF McAlary, Todd
Groenevelt, Hester
Disher, Stephen
Arnold, Jason
Seethapathy, Suresh
Sacco, Paolo
Crump, Derrick
Schumacher, Brian
Hayes, Heidi
Johnson, Paul
Gorecki, Tadeusz
TI Passive sampling for volatile organic compounds in indoor air-controlled
laboratory comparison of four sampler types
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID DIFFUSIVE SAMPLER; THERMAL-DESORPTION; VAPOR INTRUSION;
ENVIRONMENTAL-ANALYSIS; AMBIENT AIR; NEW-YORK; EXPOSURE; SOLVENT;
DEVICE; VOCS
AB This article describes laboratory testing of four passive diffusive samplers for assessing indoor air concentrations of volatile organic compounds (VOCs), including SKC Ultra II, Radiello (R), Waterloo Membrane Sampler (WMS) and Automated Thermal Desorption (ATD) tubes with two different sorbents (Tenax TA and Carbopack B). The testing included 10 VOCs (including chlorinated ethenes, ethanes, and methanes, aromatic and aliphatic hydrocarbons), spanning a range of properties and including some compounds expected to pose challenges (naphthalene, methyl ethyl ketone). Tests were conducted at different temperatures (17 to 30 degrees C), relative humidities (30 to 90% RH), face velocities (0.014 to 0.41 ms(-1)), concentrations (1 to 100 parts per billion by volume [ppb(v)]) and sampling durations (1 to 7 days). The results show that all of the passive samplers provided data that met the success criteria (relative percent difference [RPD] <= 45% of active sample concentrations and coefficient of variation [COV] <= 30%) in the majority of cases, but some compounds were problematic for some samplers. The passive sampler uptake rates depend to varying degrees on the sampler, sorbent, target compounds and environmental conditions, so field calibration is advantageous for the highest levels of data quality.
C1 [McAlary, Todd; Groenevelt, Hester] Geosyntec Consultants Inc, Guelph, ON N1G 5G3, Canada.
[Disher, Stephen; Arnold, Jason; Hayes, Heidi] Eurofins Air Tox Inc, Air Tox Ltd, Folsom, CA USA.
[McAlary, Todd; Seethapathy, Suresh; Gorecki, Tadeusz] Univ Waterloo, Waterloo, ON N2L 3G1, Canada.
[Sacco, Paolo] Fdn Salvatore Maugeri, Padua, Italy.
[Crump, Derrick] Cranfield Univ, Cranfield MK43 0AL, Beds, England.
[Schumacher, Brian] US EPA, Las Vegas, NV 89193 USA.
[Johnson, Paul] Arizona State Univ, Tempe, AZ USA.
RP McAlary, T (reprint author), Geosyntec Consultants Inc, 130 Res Lane,2, Guelph, ON N1G 5G3, Canada.
EM tmcalary@geosyntec.com
OI Gorecki, Tadeusz/0000-0001-7727-7516
FU Environmental Security Technology Certification Program (ESTCP)
FX Funding was provided by the Environmental Security Technology
Certification Program (ESTCP). Dr Samuel Brock of the Air Force Civil
Engineering Center (AFCEC) was the Department of Defense (DoD) Liaison
and Andrea Leeson of ESTCP was the Contracting Officer's Representative.
The experimental design was developed with the assistance of Brian
Schumacher and John Nocerino of EPA Research Labs in Las Vegas. We also
gratefully acknowledge Catarina Boaretto of the Fondazione Salitore
Maugeri for GC/MS analysis of the Radiello samplers. The study team
included individuals with interests in the various passive samplers (as
described in the ESI dagger), but the study design, results and
interpretation were reviewed by all coauthors and mutually considered to
provide a fair and unbiased comparison.
NR 78
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U2 28
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 5
BP 896
EP 905
DI 10.1039/c4em00560k
PG 10
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CI0FM
UT WOS:000354412100001
PM 25861049
ER
PT J
AU Schenck, K
Rosenblum, L
Ramakrishnan, B
Carson, J
Macke, D
Nietch, C
AF Schenck, Kathleen
Rosenblum, Laura
Ramakrishnan, Balaji
Carson, John, Jr.
Macke, Dana
Nietch, Christopher
TI Correlation of trace contaminants to wastewater management practices in
small watersheds
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID SURFACE WATERS; ANTIBIOTIC SULFAMETHOXAZOLE; SWEETENER SUCRALOSE;
ORGANIC-COMPOUNDS; SEWAGE-TREATMENT; TREATMENT-PLANT; DRINKING-WATER;
SEPTIC SYSTEM; PHARMACEUTICALS; FATE
AB Ten low-order streams draining headwater catchments within the East Fork Little Miami Watershed were evaluated throughout one year for the presence of six steroidal hormones, the antibiotic sulfamethoxazole, the antimicrobials triclosan and triclocarban, and the artificial sweetener sucralose. The wastewater management practices in the catchments included septic systems, sanitary sewers, a combination of both, and a parkland with no treatment systems. The concentrations and detection frequencies of sucralose showed a significant positive correlation with the septic density in each catchment. A similar relationship was found for sulfamethoxazole. Both sucralose and sulfamethoxazole are hydrophilic and unlikely to be removed effectively by sorption during septic treatment. The concentrations and detection frequencies of the antimicrobials were also positively correlated with septic density. The presence of the antimicrobials in the streams indicates that although they are hydrophobic, removal during septic treatment was incomplete. The target analytes that correlated with septic density were also detected in stream samples collected below a wastewater treatment plant located within the same watershed. The steroidal hormone estrone was the most frequently detected analyte at all sites. However, the estrone concentrations and detection frequencies did not correlate with the septic density due to multiple non-point sources.
C1 [Schenck, Kathleen; Macke, Dana; Nietch, Christopher] US EPA, Cincinnati, OH 45268 USA.
[Rosenblum, Laura; Ramakrishnan, Balaji] CB&I Fed Serv, Cincinnati, OH 45268 USA.
[Carson, John, Jr.] CB&I Fed Serv LLC, Findlay, OH 45840 USA.
RP Schenck, K (reprint author), US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM schenck.kathleen@epa.gov
FU U.S. Environmental Protection Agency
FX We thank the Clermont County Office of Environmental Quality for access
to geographic information system septic and sewer data. The U.S.
Environmental Protection Agency, through its Office of Research and
Development, funded and managed the research described herein. It has
been subjected to the Agency's peer and administrative review and has
been approved for external publication. Any opinions expressed in this
paper are those of the author(s) and do not necessarily reflect the
official positions and policies of the U.S. EPA. Any mention of trade
names or commercial products does not constitute endorsement or
recommendation for use.
NR 51
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U1 5
U2 20
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 5
BP 956
EP 964
DI 10.1039/c4em00583j
PG 9
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CI0FM
UT WOS:000354412100008
PM 25881834
ER
PT J
AU Martins, I
Sanches, B
Kaufmann, PR
Hughes, RM
Santos, GB
Molozzi, J
Callisto, M
AF Martins, Isabela
Sanches, Barbara
Kaufmann, Philip Robert
Hughes, Robert M.
Santos, Gilmar Bastos
Molozzi, Joseline
Callisto, Marcos
TI Ecological assessment of a southeastern Brazil reservoir
SO BIOTA NEOTROPICA
LA English
DT Article
DE reservoirs; water quality; bioindicators; physical habitat;
environmental quality
ID BENTHIC MACROINVERTEBRATES; COMMUNITY STRUCTURE; PHYSICAL HABITAT; FISH
ASSEMBLAGES; MINAS-GERAIS; RIVER-BASIN; DIVERSITY; PATTERNS; STREAM;
LAKES
AB Reservoirs are artificial ecosystems with multiple functions having direct and indirect benefits to humans; however, they also cause ecological changes and influence the composition and structure of aquatic biota. Our objectives were to: (1) assess the environmental condition of Nova Ponte Reservoir, Minas Gerais state, southeastern Brazil; and (2) determine how the aquatic biota respond to disturbances. A total of 40 sites in the littoral zone of the reservoir were sampled to characterize physical and chemical habitat, land use, and benthic macroinvertebrate and fish assemblages. The predominant type of land cover near the reservoir was natural vegetation. A total of 29 fish species and 39 macroinvertebrate taxa were collected, including eight alien species. Most sites had intermediate levels of human disturbance, however, high levels of degradation were associated with high proportions of alien species. Disturbances at multiple scales may alter natural patterns and processes, leading to environmental changes and damaging biological communities. Our results reinforce the importance of assessing reservoir ecological conditions at several scales. The study of land use, littoral zone physical habitat characteristics, water quality, and assemblage structure set the ground for proposing actions to rehabilitate and conserve aquatic ecosystems.
C1 [Martins, Isabela; Callisto, Marcos] Univ Fed Minas Gerais, Dept Biol Geral, Belo Horizonte, MG, Brazil.
[Sanches, Barbara; Santos, Gilmar Bastos] Pontificia Univ Catolica Minas Gerais, Programa Posgrad Zool Vertebrados, Belo Horizonte, MG, Brazil.
[Kaufmann, Philip Robert] US EPA, Western Ecol Div, Corvallis, OR USA.
[Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97331 USA.
[Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Molozzi, Joseline] Univ Estadual Paraiba, Dept Biol Geral, Campina Grande, PB, Brazil.
RP Callisto, M (reprint author), Univ Fed Minas Gerais, Dept Biol Geral, Belo Horizonte, MG, Brazil.
EM mcallisto13@gmail.com
RI Molozzi, Joseline/M-3951-2014; Callisto, Marcos/O-4930-2015
OI Callisto, Marcos/0000-0003-2341-4700
FU P&DANEEL (Projeto de Pesquisa e Desenvolvimento da Agencia Nacional de
Energia Eletrica) [GT-487]; CEMIG(Companhia Energetica de Minas Gerais)
- Programa Peixe Vivo; CAPES (Coordenacao de Aperfeicoamento de Pessoal
de Nivel Superior); CNPq (Conselho Nacional de Desenvolvimento
Cientifico e Tecnologico); FAPEMIG (Fundacao de Amparo a Pesquisa do
estado de Minas Gerais); PROGRAD/UFMG (Pro-Reitoria de Graduacao da
Universidade Federal de Minas Gerais); CNPq [302960/2011-2]; Minas
Gerais researcher grant FAPEMIG [PPM-00077/13]
FX The authors acknowledge P&DANEEL (GT-487) (Projeto de Pesquisa e
Desenvolvimento da Agencia Nacional de Energia Eletrica) and
CEMIG(Companhia Energetica de Minas Gerais) - Programa Peixe Vivo for
funding the project, CAPES (Coordenacao de Aperfeicoamento de Pessoal de
Nivel Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e
Tecnologico), FAPEMIG (Fundacao de Amparo a Pesquisa do estado de Minas
Gerais) and PROGRAD/UFMG (Pro-Reitoria de Graduacao da Universidade
Federal de Minas Gerais) for financial support. Special thanks to
colleagues from the Laboratorio de Ecologia de Bentos - UFMG. MC was
awarded research productivity grant CNPq No. 302960/2011-2) and Minas
Gerais researcher grant FAPEMIG PPM-00077/13. Reviews by Bianca Terra
and 2 anonymous referees improved the manuscript. This manuscript was
subjected to review by the National Health and Environmental Effects
Research Laboratory's Western Ecology Division and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency.
NR 78
TC 0
Z9 0
U1 2
U2 36
PU REVISTA BIOTA NEOTROPICA
PI CAMPINAS
PA AV. DR. ROMEU TORTIMA, 388 - BARAO GERALDO, CEP 13084-520, CAMPINAS, SP,
BRAZIL
SN 1676-0603
J9 BIOTA NEOTROP
JI Biota Neotrop.
PY 2015
VL 15
IS 1
DI 10.1590/1676-06032015006114
PG 10
WC Biodiversity Conservation
SC Biodiversity & Conservation
GA CH5EQ
UT WOS:000354058300007
ER
PT J
AU Wong, DC
Yang, CE
Fu, JS
Wong, K
Gao, Y
AF Wong, D. C.
Yang, C. E.
Fu, J. S.
Wong, K.
Gao, Y.
TI An approach to enhance pnetCDF performance in environmental modeling
applications
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID SYSTEM; EMISSION; OZONE
AB Data intensive simulations are often limited by their I/O (input/output) performance, and "novel" techniques need to be developed in order to overcome this limitation. The software package pnetCDF (parallel network Common Data Form), which works with parallel file systems, was developed to address this issue by providing parallel I/O capability. This study examines the performance of an application-level data aggregation approach which performs data aggregation along either row or column dimension of MPI (Message Passing Interface) processes on a spatially decomposed domain, and then applies the pnetCDF parallel I/O paradigm. The test was done with three different domain sizes which represent small, moderately large, and large data domains, using a small-scale Community Multiscale Air Quality model (CMAQ) mock-up code. The examination includes comparing I/O performance with traditional serial I/O technique, straight application of pnetCDF, and the data aggregation along row and column dimension before applying pnetCDF. After the comparison, "optimal" I/O configurations of this application-level data aggregation approach were quantified. Data aggregation along the row dimension (pnetCDFcr) works better than along the column dimension (pnetCDFcc) although it may perform slightly worse than the straight pnetCDF method with a small number of processors. When the number of processors becomes larger, pnetCDFcr outperforms pnetCDF significantly. If the number of processors keeps increasing, pnetCDF reaches a point where the performance is even worse than the serial I/O technique. This new technique has also been tested for a real application where it performs two times better than the straight pnetCDF paradigm.
C1 [Wong, D. C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Yang, C. E.; Fu, J. S.; Wong, K.; Gao, Y.] Univ Tennessee, Knoxville, TN USA.
RP Wong, DC (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM wong.david-c@epa.gov
OI Yang, Cheng-En/0000-0002-4069-4997
FU Office of Science of the US Department of Energy as part of the Regional
and Global Climate Modeling Program; DOE [DE-AC05-76RL01830]; National
Institute for Computational Sciences (NICS) [TG-ATM110009, UT-TENN0006]
FX Yang Gao was partly supported by the Office of Science of the US
Department of Energy as part of the Regional and Global Climate Modeling
Program. The Pacific Northwest National Laboratory is operated for DOE
by the Battelle Memorial Institute (DE-AC05-76RL01830). The Kraken is a
supercomputing facility through National Science Foundation TeraGrid
resources provided by the National Institute for Computational Sciences
(NICS) under grant numbers TG-ATM110009 and UT-TENN0006.
NR 17
TC 0
Z9 0
U1 0
U2 2
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 4
BP 1033
EP 1046
DI 10.5194/gmd-8-1033-2015
PG 14
WC Geosciences, Multidisciplinary
SC Geology
GA CH2FT
UT WOS:000353841800005
ER
PT J
AU Mallard, MS
Nolte, CG
Spero, TL
Bullock, OR
Alapaty, K
Herwehe, JA
Gula, J
Bowden, JH
AF Mallard, M. S.
Nolte, C. G.
Spero, T. L.
Bullock, O. R.
Alapaty, K.
Herwehe, J. A.
Gula, J.
Bowden, J. H.
TI Technical challenges and solutions in representing lakes when using WRF
in downscaling applications
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID REGIONAL CLIMATE MODEL; LAURENTIAN GREAT-LAKES; EFFECT SNOWFALL; ICE
COVER; SALT-LAKE; SIMULATION; SENSITIVITY; SYSTEM; IMPLEMENTATION;
PRECIPITATION
AB The Weather Research and Forecasting (WRF) model is commonly used to make high-resolution future projections of regional climate by downscaling global climate model (GCM) outputs. Because the GCM fields are typically at a much coarser spatial resolution than the target regional downscaled fields, lakes are often poorly resolved in the driving global fields, if they are resolved at all. In such an application, using WRF's default interpolation methods can result in unrealistic lake temperatures and ice cover at inland water points. Prior studies have shown that lake temperatures and ice cover impact the simulation of other surface variables, such as air temperatures and precipitation, two fields that are often used in regional climate applications to understand the impacts of climate change on human health and the environment. Here, alternative methods for setting lake surface variables in WRF for downscaling simulations are presented and contrasted.
C1 [Mallard, M. S.; Nolte, C. G.; Spero, T. L.; Bullock, O. R.; Alapaty, K.; Herwehe, J. A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Gula, J.] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA.
[Mallard, M. S.; Bowden, J. H.] Univ N Carolina, Inst Environm, Chapel Hill, NC 27514 USA.
RP Mallard, MS (reprint author), Univ N Carolina, Inst Environm, Chapel Hill, NC 27514 USA.
EM mmallard@email.unc.edu
RI Nolte, Christopher/H-4345-2012; Gula, Jonathan/J-9925-2012;
OI Nolte, Christopher/0000-0001-5224-9965; Gula,
Jonathan/0000-0002-0876-9557; Spero, Tanya/0000-0002-1600-0422
FU National Science Foundation
FX The lead author was supported by an appointment to the Research
Participation Program at the US Environmental Protection Agency (EPA)
Office of Research and Development, administered by the Oak Ridge
Institute for Science and Education (ORISE). The WRF model is made
available by NCAR, funded by the National Science Foundation. Great
Lakes ice cover data were obtained from GLERL
(http://www.glerl.noaa.gov/data/pgs/glice/glice.html). This research has
been subjected to the US EPA's administrative review and approved for
publication. The views expressed and the contents are solely the
responsibility of the authors and do not necessarily represent the
official views of the US EPA.
NR 55
TC 4
Z9 4
U1 0
U2 7
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 4
BP 1085
EP 1096
DI 10.5194/gmd-8-1085-2015
PG 12
WC Geosciences, Multidisciplinary
SC Geology
GA CH2FT
UT WOS:000353841800008
ER
PT J
AU Mage, DT
AF Mage, David T.
TI Comment on Schwartz, J.; Dockery, DW; Neas, ML 1996. Is daily mortality
associated specifically with fine particles?; J. Air Waste Manage.
Assoc. 46: 927-939
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Letter
ID PARTICULATE MATTER; HUMAN EXPOSURE; POLLUTION
C1 [Mage, David T.] World Hlth Org, San Francisco, CA USA.
[Mage, David T.] US EPA, San Francisco, CA USA.
NR 18
TC 0
Z9 0
U1 1
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 5
BP 511
EP 513
DI 10.1080/10962247.2015.1029812
PG 3
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CH5AU
UT WOS:000354047100001
PM 25947308
ER
PT J
AU Jones, RR
Hogrefe, C
Fitzgerald, EF
Hwang, SA
Ozkaynak, H
Garcia, VC
Lin, S
AF Jones, Rena R.
Hogrefe, Christian
Fitzgerald, Edward F.
Hwang, Syni-An
Oezkaynak, Haluk
Garcia, Valerie C.
Lin, Shao
TI Respiratory hospitalizations in association with fine PM and its
components in New York State
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID EMERGENCY-DEPARTMENT VISITS; PARTICULATE AIR-POLLUTION; SHORT-TERM
ASSOCIATIONS; CASE-CROSSOVER; CARDIORESPIRATORY DISEASES; ADMISSIONS;
PM2.5; PARTICLES; ASTHMA; MODEL
AB Despite observed geographic and temporal variation in particulate matter (PM)-related health morbidities, only a small number of epidemiologic studies have evaluated the relation between PM2.5 chemical constituents and respiratory disease. Most assessments are limited by inadequate spatial and temporal resolution of ambient PM measurements and/or by their approaches to examine the role of specific PM components on health outcomes. In a case-crossover analysis using daily average ambient PM2.5 total mass and species estimates derived from the Community Multiscale Air Quality (CMAQ) model and available observations, we examined the association between the chemical components of PM (including elemental and organic carbon, sulfate, nitrate, ammonium, and other remaining) and respiratory hospitalizations in New York State. We evaluated relationships between levels (low, medium, high) of PM constituent mass fractions, and assessed modification of the PM2.5-hospitalization association via models stratified by mass fractions of both primary and secondary PM components. In our results, average daily PM2.5 concentrations in New York State were generally lower than the 24-hr average National Ambient Air Quality Standard (NAAQS). Year-round analyses showed statistically significant positive associations between respiratory hospitalizations and PM2.5 total mass, sulfate, nitrate, and ammonium concentrations at multiple exposure lags (0.5-2.0% per interquartile range [IQR] increase). Primarily in the summer months, the greatest associations with respiratory hospitalizations were observed per IQR increase in the secondary species sulfate and ammonium concentrations at lags of 1-4 days (1.0-2.0%). Although there were subtle differences in associations observed between mass fraction tertiles, there was no strong evidence to support modification of the PM2.5-respiratory disease association by a particular constituent. We conclude that ambient concentrations of PM2.5 and secondary aerosols including sulfate, ammonium, and nitrate were positively associated with respiratory hospitalizations, although patterns varied by season. Exposure to specific fine PM constituents is a plausible risk factor for respiratory hospitalization in New York State.Implications: The association between ambient concentrations of PM2.5 components has been evaluated in only a small number of epidemiologic studies with refined spatial and temporal scale data. In New York State, fine PM and several of its constituents, including sulfate, ammonium, and nitrate, were positively associated with respiratory hospitalizations. Results suggest that PM species relationships and their influence on respiratory endpoints are complex and season dependent. Additional work is needed to better understand the relative toxicity of PM species, and to further explore the role of co-pollutant relationships and exposure prediction error on observed PM-respiratory disease associations.
C1 [Jones, Rena R.; Hwang, Syni-An; Lin, Shao] New York State Dept Hlth, Ctr Environm Hlth, Albany, NY USA.
[Jones, Rena R.; Fitzgerald, Edward F.; Hwang, Syni-An; Lin, Shao] SUNY Albany, Sch Publ Hlth, Rensselaer, NY USA.
[Hogrefe, Christian; Oezkaynak, Haluk; Garcia, Valerie C.] US EPA, Raleigh, NC USA.
RP Jones, RR (reprint author), NCI, Occupat & Environm Epidemiol Branch, 6906 Med Ctr Dr Room 6E124, Rockville, MD 20850 USA.
EM rena.jones@nih.gov
OI Lin, Shao/0000-0002-5535-7504
NR 36
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Z9 6
U1 1
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 5
BP 559
EP 569
DI 10.1080/10962247.2014.1001500
PG 11
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CH5AU
UT WOS:000354047100007
PM 25947314
ER
PT J
AU Fann, N
Nolte, CG
Dolwick, P
Spero, TL
Brown, AC
Phillips, S
Anenberg, S
AF Fann, Neal
Nolte, Christopher G.
Dolwick, Patrick
Spero, Tanya L.
Brown, Amanda Curry
Phillips, Sharon
Anenberg, Susan
TI The geographic distribution and economic value of climate change-related
ozone health impacts in the United States in 2030
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID CMAQ MODELING SYSTEM; AIR-POLLUTION; AMBIENT OZONE; MORTALITY RISKS; US
CITIES; TEMPERATURE; METAANALYSIS; ASSOCIATION; COMMUNITIES; METEOROLOGY
AB In this United States-focused analysis we use outputs from two general circulation models (GCMs) driven by different greenhouse gas forcing scenarios as inputs to regional climate and chemical transport models to investigate potential changes in near-term U.S. air quality due to climate change. We conduct multiyear simulations to account for interannual variability and characterize the near-term influence of a changing climate on tropospheric ozone-related health impacts near the year 2030, which is a policy-relevant time frame that is subject to fewer uncertainties than other approaches employed in the literature. We adopt a 2030 emissions inventory that accounts for fully implementing anthropogenic emissions controls required by federal, state, and/or local policies, which is projected to strongly influence future ozone levels. We quantify a comprehensive suite of ozone-related mortality and morbidity impacts including emergency department visits, hospital admissions, acute respiratory symptoms, and lost school days, and estimate the economic value of these impacts. Both GCMs project average daily maximum temperature to increase by 1-4 degrees C and 1-5 ppb increases in daily 8-hr maximum ozone at 2030, though each climate scenario produces ozone levels that vary greatly over space and time. We estimate tens to thousands of additional ozone-related premature deaths and illnesses per year for these two scenarios and calculate an economic burden of these health outcomes of hundreds of millions to tens of billions of U.S. dollars (2010$).Implications:Near-term changes to the climate have the potential to greatly affect ground-level ozone. Using a 2030 emission inventory with regional climate fields downscaled from two general circulation models, we project mean temperature increases of 1 to 4 degrees C and climate-driven mean daily 8-hr maximum ozone increases of 1-5 ppb, though each climate scenario produces ozone levels that vary significantly over space and time. These increased ozone levels are estimated to result in tens to thousands of ozone-related premature deaths and illnesses per year and an economic burden of hundreds of millions to tens of billions of U.S. dollars (2010$).
C1 [Fann, Neal; Dolwick, Patrick; Brown, Amanda Curry; Phillips, Sharon] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Nolte, Christopher G.; Spero, Tanya L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Anenberg, Susan] US Chem Safety & Hazard Invest Board, Washington, DC USA.
RP Fann, N (reprint author), US EPA, Off Air Qual Planning & Stand, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM fann.neal@epa.gov
RI Nolte, Christopher/H-4345-2012
OI Nolte, Christopher/0000-0001-5224-9965
NR 49
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Z9 12
U1 2
U2 26
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 5
BP 570
EP 580
DI 10.1080/10962247.2014.996270
PG 11
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CH5AU
UT WOS:000354047100008
PM 25947315
ER
PT J
AU Sorg, TJ
Wang, LL
Chen, ASC
AF Sorg, Thomas J.
Wang, Lili
Chen, Abraham S. C.
TI The costs of small drinking water systems removing arsenic from
groundwater
SO JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA
LA English
DT Article
DE arsenic; drinking water; technology demonstration; treatment cost
AB The US Environmental Protection Agency (EPA) conducted an Arsenic Demonstration Program whereby the Agency purchased, installed, and evaluated the performance and cost of 50 small water arsenic removal treatment systems in the USA. A major goal of the program was to collect high-quality cost data (capital and operational and maintenance (O&M)) from the long-term operation (1-4 years) of these systems. The technologies consisted of adsorptive media (AM), iron removal (IR), coagulation/filtration (C/F), ion exchange (IX), reverse osmosis, and point-of-use devices, which reduced the arsenic to less than the EPA maximum contaminant level of 10 mu g/L. This paper presents the capital and O&M cost of 48 treatment systems ranging in size from 10 to 770 gal/min (gpm) (382,915 L/min). The capital cost of the systems ranged from $477 to $6,171 per gpm ($126-$1,632 per L/min) of design flow and the O&M cost from $0.07 to $22.88 per 1,000 gal ($0.02-$6.05 per 1,000 L) of treated water. AM had a lower capital, but a higher O&M cost than IR, C/F, and IX. The media replacement cost for the AM systems averaged 80% of the O&M cost and was the main cause of the higher O&M cost of the AM systems.
C1 [Sorg, Thomas J.] US EPA, Cincinnati, OH 45268 USA.
[Wang, Lili] US EPA, Washington, DC 20460 USA.
[Chen, Abraham S. C.] ALSA Tech LLC, Powell, OH 43065 USA.
RP Sorg, TJ (reprint author), US EPA, Cincinnati, OH 45268 USA.
EM sorg.thomas@epa.gov
FU US Environmental Protection Agency, through its Office of Research and
Development
FX The authors wish to thank the Battelle project team for coordinating the
performance evaluation studies, data handling, and analyses efforts. The
authors also acknowledge the system operators for their data collection
efforts. The US Environmental Protection Agency, through its Office of
Research and Development, funded, managed, and collaborated in the
research described herein. This paper has been subjected to the Agency's
administrative review and has been approved for external publication.
Any opinions expressed in this paper are those of the author(s) and do
not necessarily reflect the views of the Agency, therefore, no official
endorsement should be inferred. Any mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
NR 10
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Z9 2
U1 2
U2 12
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0003-7214
EI 1365-2087
J9 J WATER SUPPLY RES T
JI J. Water Supply Res Technol.-Aqua
PY 2015
VL 64
IS 3
BP 219
EP 234
DI 10.2166/aqua.2014.044
PG 16
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA CH8JD
UT WOS:000354281700001
ER
PT J
AU Das, KP
Grey, BE
Rosen, MB
Wood, CR
Tatum-Gibbs, KR
Zehr, RD
Strynar, MJ
Lindstrom, AB
Lau, C
AF Das, Kaberi P.
Grey, Brian E.
Rosen, Mitchell B.
Wood, Carmen R.
Tatum-Gibbs, Katoria R.
Zehr, R. Daniel
Strynar, Mark J.
Lindstrom, Andrew B.
Lau, Christopher
TI Developmental toxicity of perfluorononanoic acid in mice
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Perfluorononanoic acid; CD-1 mice; Developmental toxicity; Gene
expression
ID ACTIVATED RECEPTOR-ALPHA; PERFLUOROOCTANE SULFONATE PFOS; ATTENTION
DEFICIT/HYPERACTIVITY DISORDER; EXPOSED MOUSE FETUSES; HUMAN SEMEN
QUALITY; IN-UTERO EXPOSURE; PERFLUORINATED CHEMICALS; PERFLUOROALKYL
ACIDS; PPAR-ALPHA; POLYFLUOROALKYL CHEMICALS
AB Perfluorononanoic acid (PFNA) is a ubiquitous and persistent environmental contaminant. Although its levels in the environment and in humans are lower than those of perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA), a steady trend of increases in the general population in recent years has drawn considerable interest and concern. Previous studies with PFOS and PFOA have indicated developmental toxicity in laboratory rodent models. The current study extends the evaluation of these adverse outcomes to PFNA in mice. PFNA was given to timed-pregnant CD-I mice by oral gavage daily on gestational day 1-17 at 1, 3, 5 or 10 mg/kg; controls received water vehicle. Dams given 10 mg/kg PFNA could not carry their pregnancy successfully and effects of this dose group were not followed. Similar to PFOS and PFOA, PFNA at 5 mg/kg or lower doses produced hepatomegaly in the pregnant dams, but did not affect the number of implantations, fetal viability, or fetal weight. Mouse pups were born alive and postnatal survival in the I and 3 mg/kg PFNA groups was not different from that in controls. In contrast, although most of the pups were also born alive in the 5 mg/kg PFNA group, 80% of these neonates died in the first 10 days of life. The pattern of PFNA-induced neonatal death differed somewhat from those elicited by PFOS or PFOA. A majority of the PFNA-exposed pups survived a few days longer after birth than those exposed to PFOS or PFOA, which typically died within the first 2 days of postnatal life. Surviving neonates exposed to PFNA exhibited dose-dependent delays in eye opening and onset of puberty. In addition, increased liver weight seen in PFNA-exposed offspring persisted into adulthood and was likely related to the persistence of the chemical in the tissue. Evaluation of gene expression in fetal and neonatal livers revealed robust activation of peroxisome proliferator-activated receptor-alpha (PPAR alpha) target genes by PFNA that resembled the responses of PFOA. Our results indicate that developmental toxicity of PFNA in mice is comparable to that of PFOS and PFOA, and that these adverse effects are likely common to perfluoroalkyl acids that persist in the body. Published by Elsevier Inc.
C1 [Das, Kaberi P.; Grey, Brian E.; Wood, Carmen R.; Tatum-Gibbs, Katoria R.; Lau, Christopher] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
[Rosen, Mitchell B.] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Zehr, R. Daniel] US EPA, Res Core Unit, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Strynar, Mark J.; Lindstrom, Andrew B.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Lau, C (reprint author), US EPA, Mail Drop 8105-04, Res Triangle Pk, NC 27711 USA.
EM lau.christopher@epa.gov
FU U.S. Environmental Protection Agency
FX The information in this document has been funded by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 85
TC 6
Z9 6
U1 2
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JAN
PY 2015
VL 51
BP 133
EP 144
DI 10.1016/j.reprotox.2014.12.012
PG 12
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA CH6NH
UT WOS:000354152800016
PM 25543169
ER
PT J
AU Bouhifd, M
Andersen, ME
Baghdikian, C
Boekelheide, K
Crofton, KM
Fornace, AJ
Kleensang, A
Li, HH
Livi, C
Maertens, A
McMullen, PD
Rosenberg, M
Thomas, R
Vantangoli, M
Yager, JD
Zhao, L
Hartung, T
AF Bouhifd, Mounir
Andersen, Melvin E.
Baghdikian, Christina
Boekelheide, Kim
Crofton, Kevin M.
Fornace, Albert J., Jr.
Kleensang, Andre
Li, Henghong
Livi, Carolina
Maertens, Alexandra
McMullen, Patrick D.
Rosenberg, Michael
Thomas, Russell
Vantangoli, Marguerite
Yager, James D.
Zhao, Liang
Hartung, Thomas
TI The Human Toxome Project
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Article
DE regulatory toxicology; safety sciences; transcriptomics; metabolomics;
alternative methods
ID EVIDENCE-BASED TOXICOLOGY; GREEN FLUORESCENT PROTEIN;
ESTROGEN-RECEPTOR-ALPHA; CELL-CULTURE PRACTICE; BREAST-CANCER CELLS;
RISK-ASSESSMENT; BISPHENOL-A; 21(ST) CENTURY; REGULATORY USE; DNA-DAMAGE
AB The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies.
C1 [Bouhifd, Mounir; Kleensang, Andre; Maertens, Alexandra; Zhao, Liang; Hartung, Thomas] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD 21205 USA.
[Andersen, Melvin E.; McMullen, Patrick D.] Hamner Inst, Res Triangle Pk, NC USA.
[Baghdikian, Christina; Crofton, Kevin M.; Thomas, Russell] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Boekelheide, Kim; Vantangoli, Marguerite] Brown Univ, Pathol & Lab Med, Providence, RI 02912 USA.
[Fornace, Albert J., Jr.; Li, Henghong] Georgetown Univ, Med Ctr, Washington, DC 20007 USA.
[Livi, Carolina; Rosenberg, Michael] Agilent Inc, Santa Clara, CA USA.
[Yager, James D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
[Hartung, Thomas] Univ Konstanz, Ctr Alternat Anim Testing Europe, Constance, Germany.
RP Hartung, T (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, 615 N Wolfe St,W7032, Baltimore, MD 21205 USA.
EM thartung@jhsph.edu
RI Crofton, Kevin/J-4798-2015; Zhao, Liang/I-4777-2015;
OI Crofton, Kevin/0000-0003-1749-9971; Zhao, Liang/0000-0002-2126-6778;
Fornace, Albert/0000-0001-9695-085X; Thomas,
Russell/0000-0002-2340-0301; Kleensang, Andre/0000-0002-4564-7399
FU NIH Transformation Research Grant, "Mapping the Human Toxome by Systems
Toxicsology" [RO1 ES 020750]; Food and Drug Administration Grant
"DNTox-21c Identification of Pathways of Developmental Neurotoxicity for
High Throughput Testing by Metabolomies" [U01 FD 004230]
FX The employment affiliations of the authors of this paper are as shown on
the cover page. Ten of the authors are affiliated with universities that
have traditional roles of teaching, research and service. Two of the
authors are associated with the U.S. Environmental Protection Agency.
Two of the authors are associated with a non-profit institution, The
Hamner Institute, which has an interest in advancing the science of
toxicology and risk assessment. And two of the authors are employees of
Agilent Technologies, Inc., a for-profit company that provides advanced
bio-analytical equipment and measurement services to a wide range of
clients. The individual authors were compensated by their respective
employers. In some cases, funding was provided by an NIH Transformation
Research Grant, "Mapping the Human Toxome by Systems Toxicsology" (RO1
ES 020750) to Johns Hopkins Bloomberg School of Public Health (PI Thomas
Hartung) and Food and Drug Administration Grant "DNTox-21c
Identification of Pathways of Developmental Neurotoxicity for High
Throughput Testing by Metabolomies" (U01 FD 004230) to Johns Hopkins
Bloomberg School of Public Health (PI Thomas Hartung). The analyses,
interpretations and conclusions presented in this paper are the
professional work product of the authors and may not necessarily
represent the views of their employers.
NR 102
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Z9 20
U1 3
U2 13
PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
PI HEILDEBERG
PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY
SN 1868-596X
EI 1868-8551
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2015
VL 32
IS 2
BP 112
EP 124
DI 10.14573/altex.1502091
PG 13
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CG9UZ
UT WOS:000353666900004
PM 25742299
ER
PT J
AU Sangani, RG
Ghio, AJ
Parker, JE
AF Sangani, Rahul G.
Ghio, Andrew J.
Parker, John E.
TI Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis
SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
LA English
DT Letter
C1 [Sangani, Rahul G.; Parker, John E.] W Virginia Univ, Dept Pulm & Crit Care Med, Morgantown, WV 26505 USA.
[Ghio, Andrew J.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Sangani, RG (reprint author), W Virginia Univ, Dept Pulm & Crit Care Med, Robert C Byrd Hlth Sci Ctr, 1 Med Ctr Dr, Morgantown, WV 26505 USA.
EM rgsangani@hsc.wvu.edu
NR 6
TC 0
Z9 1
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2005
J9 INT J CHRONIC OBSTR
JI Int. J. Chronic Obstr. Pulm. Dis.
PY 2015
VL 10
BP 869
EP 870
DI 10.2147/COPD.S83564
PG 2
WC Respiratory System
SC Respiratory System
GA CH2XD
UT WOS:000353887500001
PM 25999705
ER
PT J
AU Harper, M
Butler, C
Berry, D
Wroble, J
AF Harper, Martin
Butler, Corey
Berry, David
Wroble, Julie
TI Where Occupation and Environment Overlap: US Forest Service Worker
Exposure to Libby Amphibole Fibers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
LA English
DT Article
ID MONTANA
AB The National Institute for Occupational Safety and Health (NIOSH) conducted an evaluation of exposures to asbestiform amphibole, known as Libby Amphibole (LA), to personnel from the US Department of Agriculture-Forest Service (USFS) working in the Kootenai National Forest near a former vermiculite mine close to Libby, Montana. LA is associated with vermiculite that was obtained from this mine; mining and processing over many years have resulted in the spread of LA into the surrounding Kootenai Forest where it has been found in tree bark, soil, and forest floor litter. As a result of this and other contamination, Libby and surrounding areas have been designated a "Superfund" site by the US Environmental Protection Agency (EPA). This article describes the application of EPA methods for assessing cancer risks to NIOSH sampling results. Phase-contrast microscopy for airborne asbestos fiber evaluation was found to be less useful than transmission electron microscopy in the presence of interfering organic (plant) fibers. NIOSH Method 7402 was extended by examination of larger areas of the filter, but fiber counts remained low. There are differences between counting rules in NIOSH 7402 and the ISO method used by EPA but these are minor in the context of the uncertainty in concentration estimates from the low counts. Estimates for cancer risk are generally compatible with those previously estimated by the EPA. However, there are limitations to extrapolating these findings of low risk throughout the entire area and to tasks that were not evaluated.
C1 [Harper, Martin] NIOSH, Hlth Effects Lab Div, Exposure Assessment Branch, Morgantown, WV 26505 USA.
[Butler, Corey] NIOSH, Western States Off, Denver, CO USA.
[Berry, David] US EPA, Denver, CO USA.
[Wroble, Julie] US EPA, Seattle, WA USA.
RP Harper, M (reprint author), NIOSH, Hlth Effects Lab Div, Exposure Assessment Branch, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM zzg7@cdc.gov
FU Intramural CDC HHS [CC999999]
NR 14
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U1 1
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1545-9624
EI 1545-9632
J9 J OCCUP ENVIRON HYG
JI J. Occup. Environ. Hyg.
PY 2015
VL 12
IS 5
BP D47
EP D53
DI 10.1080/15459624.2014.989362
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA CG8UP
UT WOS:000353590000001
PM 25715191
ER
PT J
AU Lewandowski, M
Jaoui, M
Offenberg, JH
Krug, JD
Kleindienst, TE
AF Lewandowski, M.
Jaoui, M.
Offenberg, J. H.
Krug, J. D.
Kleindienst, T. E.
TI Atmospheric oxidation of isoprene and 1,3-butadiene: influence of
aerosol acidity and relative humidity on secondary organic aerosol
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID ENVIRONMENTAL TOBACCO-SMOKE; HIGH-NOX CONDITIONS; OCCUPATIONAL
EXPOSURES; BUTADIENE; PHOTOOXIDATION; MODEL; EMISSIONS; EPOXIDE; CARBON;
ORGANOSULFATES
AB The effects of acidic seed aerosols on the formation of secondary organic aerosol (SOA) have been examined in a number of previous studies, several of which have observed strong linear correlations between the aerosol acidity (measured as nmol H+ m(-3) air sample volume) and the percent change in secondary organic carbon (SOC). The measurements have used several precursor compounds representative of different classes of biogenic hydrocarbons including isoprene, monoterpenes, and sesquiterpenes. To date, isoprene has displayed the most pronounced increase in SOC, although few measurements have been conducted with anthropogenic hydrocarbons. In the present study, we examine several aspects of the effect of aerosol acidity on the secondary organic carbon formation from the photooxidation of 1,3-butadiene, and extend the previous analysis of isoprene. The photooxidation products measured in the absence and presence of acidic sulfate aerosols were generated either through photochemical oxidation of SO2 or by nebulizing mixtures of ammonium sulfate and sulfuric acid into a 14.5 m(3) smog chamber system. The results showed that, like isoprene and beta-caryophyllene, 1,3-butadiene SOC yields linearly correlate with increasing acidic sulfate aerosol. The observed acid sensitivity of 0.11% SOC increase per nmol m(-3) increase in H+ was approximately a factor of 3 less than that measured for isoprene. The results also showed that the aerosol yield decreased with increasing humidity for both isoprene and 1,3-butadiene, although to different degrees. Increasing the absolute humidity from 2 to 12 gm(-3) reduced the 1,3-butadiene yield by 45% and the isoprene yield by 85 %.
C1 [Lewandowski, M.; Offenberg, J. H.; Krug, J. D.; Kleindienst, T. E.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Jaoui, M.] Alion Sci & Technol Inc, Res Triangle Pk, NC 27709 USA.
RP Lewandowski, M (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM lewandowski.michael@epa.gov
RI Offenberg, John/C-3787-2009
OI Offenberg, John/0000-0002-0213-4024
FU US Environmental Protection Agency through Office of Research and
Development [EP-D-10-070]
FX The US Environmental Protection Agency through its Office of Research
and Development funded and collaborated in the research described here
under contract EP-D-10-070 to Alion Science and Technology. It has been
subject to agency review and approved for publication. Mention of trade
names or commercial products does not constitute an endorsement or
recommendation for use.
NR 39
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U1 8
U2 51
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 7
BP 3773
EP 3783
DI 10.5194/acp-15-3773-2015
PG 11
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CG0LF
UT WOS:000352957400009
ER
PT J
AU Yu, L
Fennel, K
Laurent, A
Murrell, MC
Lehrter, JC
AF Yu, L.
Fennel, K.
Laurent, A.
Murrell, M. C.
Lehrter, J. C.
TI Numerical analysis of the primary processes controlling oxygen dynamics
on the Louisiana shelf
SO BIOGEOSCIENCES
LA English
DT Article
ID GULF-OF-MEXICO; MISSISSIPPI RIVER PLUME; EUTROPHIC COASTAL ECOSYSTEM;
CONTINENTAL-SHELF; CHESAPEAKE BAY; SKILL ASSESSMENT; SUMMER HYPOXIA;
WATER COLUMN; MODEL; VARIABILITY
AB The Louisiana shelf, in the northern Gulf of Mexico, receives large amounts of freshwater and nutrients from the Mississippi-Atchafalaya river system. These river inputs contribute to widespread bottom-water hypoxia every summer. In this study, we use a physical-biogeochemical model that explicitly simulates oxygen sources and sinks on the Louisiana shelf to identify the key mechanisms controlling hypoxia development. First, we validate the model simulation against observed dissolved oxygen concentrations, primary production, water column respiration, and sediment oxygen consumption. In the model simulation, heterotrophy is prevalent in shelf waters throughout the year, except near the mouths of the Mississippi and Atchafalaya rivers, where primary production exceeds respiratory oxygen consumption during June and July. During this time, efflux of oxygen to the atmosphere, driven by photosynthesis and surface warming, becomes a significant oxygen sink. A substantial fraction of primary production occurs below the pycnocline in summer. We investigate whether this primary production below the pycnocline is mitigating the development of hypoxic conditions with the help of a sensitivity experiment where we disable biological processes in the water column (i.e., primary production and water column respiration). With this experiment we show that below-pycnocline primary production reduces the spatial extent of hypoxic bottom waters only slightly. Our results suggest that the combination of physical processes (advection and vertical diffusion) and sediment oxygen consumption largely determine the spatial extent and dynamics of hypoxia on the Louisiana shelf.
C1 [Yu, L.; Fennel, K.; Laurent, A.] Dalhousie Univ, Dept Oceanog, Halifax, NS, Canada.
[Murrell, M. C.; Lehrter, J. C.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Yu, L (reprint author), Dalhousie Univ, Dept Oceanog, Halifax, NS, Canada.
EM liuqian.yu@dal.ca
RI Fennel, Katja/A-7470-2009;
OI Fennel, Katja/0000-0003-3170-2331; Laurent, Arnaud/0000-0002-8545-9309
FU NOAA CSCOR grants [NA06N0S4780198]; US IOOS Coastal Ocean Modeling
Testbed
FX This work was supported through NOAA CSCOR grants NA06N0S4780198 and the
US IOOS Coastal Ocean Modeling Testbed. NOAA NGOMEX publication no. 202.
NR 58
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U1 1
U2 13
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1726-4170
EI 1726-4189
J9 BIOGEOSCIENCES
JI Biogeosciences
PY 2015
VL 12
IS 7
BP 2063
EP 2076
DI 10.5194/bg-12-2063-2015
PG 14
WC Ecology; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA CG0LP
UT WOS:000352958400001
ER
PT J
AU Druschke, CG
Hychka, KC
AF Druschke, Caroline Gottschalk
Hychka, Kristen C.
TI Manager perspectives on communication and public engagement in
ecological restoration project success
SO ECOLOGY AND SOCIETY
LA English
DT Article
DE adaptive comanagement; adaptive management; communication; discourse
analysis; natural resource management; public engagement; public
participation; restoration; river; stakeholder engagement; water
ID RIVER RESTORATION; PARTICIPATION; SCIENTISTS; SYSTEMS; TIME
AB We look to a particular social-ecological system, the restoration community in Rhode Island, USA and the rivers, wetlands, marshes, and estuaries they work to protect, to draw connections between communication, community involvement, and ecological restoration project success. Offering real-world examples drawn from interviews with 27 local, state, federal, and nonprofit restoration managers, we synthesize the mechanisms that managers found effective to argue that the communication employed by resource managers in each phase of the restoration process, in prioritization, implementation, and monitoring, and for garnering broad-based support, shapes the quality of public engagement in natural resources management, which, in turn, can impact the stakeholder, learning, and ecological success of restoration projects. Despite the possible trade-offs and conflicts between social and ecological outcomes, we suggest that managers need to consider their desired social-ecological outcomes and work from the outset to deliberately design mechanisms for communication and public engagement that weave community stakeholders into all phases of restoration projects in sustained and consequential ways.
C1 [Druschke, Caroline Gottschalk] Univ Rhode Isl, Kingston, RI 02881 USA.
[Hychka, Kristen C.] US EPA, Atlantic Ecol Div, Washington, DC USA.
RP Druschke, CG (reprint author), Univ Rhode Isl, Kingston, RI 02881 USA.
NR 36
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U1 11
U2 36
PU RESILIENCE ALLIANCE
PI WOLFVILLE
PA ACADIA UNIV, BIOLOGY DEPT, WOLFVILLE, NS B0P 1X0, CANADA
SN 1708-3087
J9 ECOL SOC
JI Ecol. Soc.
PY 2015
VL 20
IS 1
AR 58
DI 10.5751/ES-07451-200158
PG 9
WC Ecology; Environmental Studies
SC Environmental Sciences & Ecology
GA CG4XW
UT WOS:000353293900067
ER
PT J
AU Schaeffer, BA
Conmy, RN
Duffy, AE
Aukamp, J
Yates, DF
Craven, G
AF Schaeffer, Blake A.
Conmy, Robyn N.
Duffy, Allyn E.
Aukamp, Jessica
Yates, Diane F.
Craven, George
TI Northern Gulf of Mexico estuarine coloured dissolved organic matter
derived from MODIS data
SO INTERNATIONAL JOURNAL OF REMOTE SENSING
LA English
DT Article
ID WATER-QUALITY INDICATORS; OCEAN COLOR; COASTAL WATERS;
OPTICAL-PROPERTIES; CLYDE SEA; TAMPA-BAY; VARIABILITY; SEAWIFS; FLORIDA;
CARBON
AB Coloured dissolved organic matter (CDOM) is relevant for water quality management and may become an important measure to complement future water quality assessment programmes. An approach to derive CDOM using the Moderate Resolution Imaging Spectroradiometer (MODIS) was developed that may be more accessible to water quality managers by selecting an off-the-shelf software and algorithm with standard atmospheric correction. This study focused on demonstrating the transferability of a remote-sensing reflectance (R-rs) band ratio algorithm, R-rs(667)/R-rs(488), previously developed to derive CDOM absorption (a(g(lambda))) at multiple MODIS wavebands in open ocean and coastal waters to the United States northern Gulf of Mexico estuaries. In situ calibration regressions at 412, 443, 469, and 488 nm had coefficients of determination (R-2) of 0.76, 0.71, 0.69, and 0.57, respectively. Waveband calibrations at 531, 547, and 555 nm were below R-2 = 0.50, and therefore were not considered further. MODIS R-rs, from the standard atmospheric correction, followed nearly identical spectral shapes to the in situ HyperSAS R-rs, but were on average 0.002 + 0.0004 sr(-1) less. A satellite to in situ validation match-up window of <= 1 hour was selected with an R-2 = 0.82 and root mean square error (RMSE = 1.79) at 412 nm. An in situ water quality mooring demonstrated that the overall response and range of MODIS a(g(412)) were similar, with relative mean error from -32% to 42%. The advantage to managers was synoptic coverage across multiple estuaries and the ability to provide estimates of derived water quality parameters between the water quality assessment programme sample collection periods, which could offer more holistic assessment.
C1 [Schaeffer, Blake A.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Conmy, Robyn N.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
[Duffy, Allyn E.; Aukamp, Jessica; Yates, Diane F.; Craven, George] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Gulf Breeze, FL USA.
RP Schaeffer, BA (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM schaeffer.blake@epa.gov
FU US Environmental Protection Agency; NASA [NNH08ZDA001N-DECISIONS]
FX The information in this document has been funded in part by the US
Environmental Protection Agency and NASA Grant # NNH08ZDA001N-DECISIONS.
NR 53
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U1 2
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0143-1161
EI 1366-5901
J9 INT J REMOTE SENS
JI Int. J. Remote Sens.
PY 2015
VL 36
IS 8
BP 2219
EP 2237
DI 10.1080/01431161.2015.1035408
PG 19
WC Remote Sensing; Imaging Science & Photographic Technology
SC Remote Sensing; Imaging Science & Photographic Technology
GA CG8RG
UT WOS:000353577600013
ER
PT J
AU Oczkowski, A
Thornber, CS
Markham, EE
Rossi, R
Ziegler, A
Rinehart, S
AF Oczkowski, Autumn
Thornber, Carol S.
Markham, Erin E.
Rossi, Ryann
Ziegler, Amanda
Rinehart, Shelby
TI Testing sample stability using four storage methods and the macroalgae
Ulva and Gracilaria
SO LIMNOLOGY AND OCEANOGRAPHY-METHODS
LA English
DT Article
ID ANTHROPOGENIC NITROGEN
AB Concern over the relative importance of different sample preparation and storage techniques frequently used in stable isotope analysis of particulate nitrogen (delta N-15) and carbon (delta C-13) prompted an experiment to determine how important such factors were to measured values in marine organisms. We stored the marine macroalgae Ulva and Gracilaria in four different ways and analyzed replicates every three months over the course of a year to assess treatment effects on stability. Treatments consisted of algae dried at 65 degrees C, ground to a powder, and stored in a desiccator until analysis; algae left in a drying oven or in a freezer and processed (dried and ground) just prior to analysis, as well as some dried, ground samples kept out in the lab and reanalyzed quarterly for 12 months. Concurrently, to assess the ecological range in isotope values over the course of a year, samples were freshly collected from the same location and analyzed along with the other treatments at each time step. Neither storage technique nor time had an impact on either delta N-15 or delta C-13 values or the %N and %C of the algae tissues. There were clear and consistent differences between species and some large seasonal differences in the freshly collected samples. The interspecies differences and seasonal ranges of values underscore the stability associated with method and duration of sample storage.
C1 [Oczkowski, Autumn; Markham, Erin E.; Rossi, Ryann] US EPA, Grad Sch Oceanog, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Thornber, Carol S.; Ziegler, Amanda; Rinehart, Shelby] Univ Rhode Isl, Dept Biol Sci, Kingston, RI 02881 USA.
RP Oczkowski, A (reprint author), US EPA, Grad Sch Oceanog, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM Oczkowski.Autumn@epa.gov
FU University of Rhode Island; National Science Foundation EPSCoR
Cooperative Agreement [EPS-1004057]; State of Rhode Island; U.S.
Environmental Protection Agency
FX Thank you to R. McKinney for assistance with sample analysis, and to J.
Carey, R. Johnson, and M. Pelletier for providing useful edits of this
manuscript. Partial funding was provided by the University of Rhode
Island through an undergraduate research grant to A. Ziegler. This
material is based, in part, upon work supported in part by the National
Science Foundation EPSCoR Cooperative Agreement #EPS-1004057 and the
State of Rhode Island. This is ORD Tracking Number ORD-008193 of the
Atlantic Ecology Division, National Health and Environmental Effects
Research Laboratory, Office of Research and Development, U.S.
Environmental Protection Agency. Although the research described in this
article has been funded in part by the U.S. Environmental Protection
Agency, it has not been subjected to Agency review. Therefore, it does
not necessarily reflect the views of the Agency.
NR 10
TC 0
Z9 0
U1 3
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1541-5856
J9 LIMNOL OCEANOGR-METH
JI Limnol. Oceanogr. Meth.
PD JAN
PY 2015
VL 13
IS 1
BP 9
EP 14
DI 10.1002/lom3.10002
PG 6
WC Limnology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA CG8KH
UT WOS:000353555800002
ER
PT J
AU Trebitz, AS
Hoffman, JC
AF Trebitz, Anett S.
Hoffman, Joel C.
TI Coastal Wetland Support of Great Lakes Fisheries: Progress from Concept
to Quantification
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID FRESH-WATER ECOSYSTEMS; ESSENTIAL FISH HABITAT; YELLOW PERCH; LARVAL
FISHES; ENVIRONMENTAL INDICATORS; SAMPLING DESIGN; LARGEMOUTH BASS;
FORAGE FISH; LAND-USE; MICHIGAN
AB Fishery support is recognized as a valuable ecosystem service provided by aquatic systems, but it is harder to quantify than to describe conceptually. In this paper, we combine data on fish inhabiting Great Lakes coastal wetlands (GLCWs) with information on commercial and recreational harvest and the piscivore forage base to develop quantitative understanding of the multiple species involved in direct and indirect fishery support of this complex fishery. We then examine patterns of species co-occurrence and life history and relationships to GLCW conditions in order to identify fishery support metrics useful in aggregating species patterns and evaluating management outcomes. Our criteria for wetland prevalence (>= 10% occurrence) and fishery importance (>= 1% of recreational or commercial harvest in one or more of the Great Lakes or having a major forage fish role) yielded 21 wetland-using, fishery-relevant species representing multiple taxonomic groups and life history attributes. Wetland-using species are estimated to make up half the biomass and 60% of the dollar value of the fish landed commercially and similar to 80% of the fish numbers harvested recreationally. All of the GLCWs studied supported species of interest to recreational and commercial fishers but with widely varying composition. A few key habitat characteristics (e.g., vegetation structure) are broadly predictive of the types of sport and panfish present, with more degraded GLCWs generally supporting abundant but lower-value taxa (rough-fish species) and less degraded GLCWs supporting fewer but higher-value taxa (sport and panfish species). No single taxonomic or functional metric seems adequate to capture the diversity of fishery-relevant species supported by GLCWs; fishery support needs to be understood and managed in a multimetric context.
C1 [Trebitz, Anett S.; Hoffman, Joel C.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Trebitz, AS (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM trebitz.anett@epa.gov
NR 123
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U1 5
U2 29
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0002-8487
EI 1548-8659
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PY 2015
VL 144
IS 2
BP 352
EP 372
DI 10.1080/00028487.2014.982257
PG 21
WC Fisheries
SC Fisheries
GA CF7HE
UT WOS:000352726200013
ER
PT J
AU Heenan, J
Slater, LD
Ntarlagiannis, D
Atekwana, EA
Fathepure, BZ
Dalvi, S
Ross, C
Werkema, DD
Atekwana, EA
AF Heenan, Jeffrey
Slater, Lee D.
Ntarlagiannis, Dimitrios
Atekwana, Estella A.
Fathepure, Babu Z.
Dalvi, Sonal
Ross, Cameron
Werkema, Dale D.
Atekwana, Eliot A.
TI Electrical resistivity imaging for long-term autonomous monitoring of
hydrocarbon degradation: Lessons from the Deepwater Horizon oil spill
SO GEOPHYSICS
LA English
DT Article
ID ATTENUATION ANALYSIS; PHENOL HYDROXYLASE; DC RESISTIVITY; TOMOGRAPHY;
SEDIMENTS; BACTERIA; BIODEGRADATION; SIGNATURES; INVERSION; TRANSPORT
AB Conceptual models for the geophysical responses associated with hydrocarbon degradation suggest that the long-term evolution of an oil plume will result in a more conductive anomaly than the initial contamination. In response to the Deepwater Horizon (DH) oil spill into the Gulf of Mexico in 2010, an autonomous resistivity monitoring system was deployed on Grand Terre, Louisiana, in an attempt to monitor natural degradation processes in hydrocarbon-impacted beach sediments of this island. A 48-electrode surface array with a 0.5-m spacing was installed to obtain twice-daily images of the resistivity structure of the shallow subsurface impacted by oil. Over the course of approximately 18 months, we observed a progressive decrease in the resistivity of the DH spill-impacted region. Detailed analysis of pixel/point resistivity variation within the imaged area showed that long-term decreases in resistivity were largely associated with the DH-impacted sediments. A microbial diversity survey revealed the presence of hydrocarbon-degrading organisms throughout the test site. However, hydrocarbon degradation activity was much higher in the DH-impacted locations compared to nonimpacted locations, suggesting the presence of active hydrocarbon degraders, supporting biodegradation processes. The results of this long-term monitoring experiment suggested that resistivity might be used to noninvasively monitor the long-term degradation of crude oil spills.
C1 [Heenan, Jeffrey; Slater, Lee D.; Ntarlagiannis, Dimitrios] Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA.
[Atekwana, Estella A.; Ross, Cameron; Atekwana, Eliot A.] Oklahoma State Univ, Boone Pickens Sch Geol, Stillwater, OK 74078 USA.
[Fathepure, Babu Z.; Dalvi, Sonal] Oklahoma State Univ, Microbiol & Mol Genet, Stillwater, OK 74078 USA.
[Werkema, Dale D.] US EPA, Las Vegas, NV 89193 USA.
RP Heenan, J (reprint author), Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA.
EM jheenan@pegasus.rutgers.edu; lslater@rutgers.edu; dimntar@rutgers.edu;
estella.atekwana@okstate.edu; babu.fathepure@okstate.edu;
sonal.dalvi@okstate.edu; camersr@ostatemail.okstate.edu;
werkema.d@epamail.epa.gov; eliot.atekwana@okstate.edu
OI atekwana, eliot/0000-0002-4934-650X
FU United States Environmental Protection Agency National Exposure Research
Laboratory, Office of Research and Development Student Services
[RFQ-RT-11-00103]; National Science Foundation [OCE-1049301]; American
Chemical Society, Petroleum Research Fund [49823-ND8]; Chevron Energy
Corporation
FX This work was supported by the United States Environmental Protection
Agency National Exposure Research Laboratory, Office of Research and
Development Student Services Contract RFQ-RT-11-00103 to J. Heenan,
National Science Foundation RAPID Award, OCE-1049301, American Chemical
Society, Petroleum Research Fund, grant no. 49823-ND8, and the Chevron
Energy Corporation.
NR 43
TC 3
Z9 3
U1 2
U2 7
PU SOC EXPLORATION GEOPHYSICISTS
PI TULSA
PA 8801 S YALE ST, TULSA, OK 74137 USA
SN 0016-8033
EI 1942-2156
J9 GEOPHYSICS
JI Geophysics
PD JAN-FEB
PY 2015
VL 80
IS 1
BP B1
EP B11
DI 10.1190/GEO2013-0468.1
PG 11
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA CE8PN
UT WOS:000352105900005
ER
PT J
AU Gantt, B
Johnson, MS
Crippa, M
Prevot, ASH
Meskhidze, N
AF Gantt, B.
Johnson, M. S.
Crippa, M.
Prevot, A. S. H.
Meskhidze, N.
TI Implementing marine organic aerosols into the GEOS-Chem model
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID SEA-SPRAY AEROSOL; SOURCE APPORTIONMENT; GLOBAL DISTRIBUTION; MATTER
ENRICHMENT; DRY DEPOSITION; ARCTIC-OCEAN; EMISSIONS; ISOPRENE;
PARAMETERIZATION; PARTICLES
AB Marine-sourced organic aerosols (MOAs) have been shown to play an important role in tropospheric chemistry by impacting surface mass, cloud condensation nuclei, and ice nuclei concentrations over remote marine and coastal regions. In this work, an online marine primary organic aerosol emission parameterization, designed to be used for both global and regional models, was implemented into the GEOS-Chem (Global Earth Observing System Chemistry) model. The implemented emission scheme improved the large underprediction of organic aerosol concentrations in clean marine regions (normalized mean bias decreases from -79% when using the default settings to -12% when marine organic aerosols are added). Model predictions were also in good agreement (correlation coefficient of 0.62 and normalized mean bias of -36%) with hourly surface concentrations of MOAs observed during the summertime at an inland site near Paris, France. Our study shows that MOAs have weaker coastal-to-inland concentration gradients than sea-salt aerosols, leading to several inland European cities having > 10% of their surface submicron organic aerosol mass concentration with a marine source. The addition of MOA tracers to GEOS-Chem enabled us to identify the regions with large contributions of freshly emitted or aged aerosol having distinct physicochemical properties, potentially indicating optimal locations for future field studies.
C1 [Gantt, B.; Meskhidze, N.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Johnson, M. S.] NASA, Ames Res Ctr, Div Earth Sci, Moffett Field, CA 94035 USA.
[Crippa, M.; Prevot, A. S. H.] Paul Scherrer Inst, Lab Atmospher Chem, Villigen, Switzerland.
RP Gantt, B (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM bdgantt@gmail.com
RI Prevot, Andre/C-6677-2008; Chem, GEOS/C-5595-2014
OI Prevot, Andre/0000-0002-9243-8194;
FU Office of Science (BER), US Department of Energy [DEFG02-08ER64508];
National Science Foundation [ATM-0826117]; National Aeronautics & Space
Administration (NASA) [NNX11AG72G]; European Community [212520]; Office
of Research and Development, US EPA
FX This research was supported by the Office of Science (BER), US
Department of Energy grant no. DEFG02-08ER64508, National Science
Foundation grant no. ATM-0826117, and National Aeronautics & Space
Administration (NASA) through grant no. NNX11AG72G. The measurements in
Paris were conducted in the MEGAPOLI project, mainly financially
supported by the European Community's Framework Program FP/2007-2011
under grant agreement no. 212520. The authors would like to thank Daniel
Jacob and the Harvard University Atmospheric Chemistry Modeling Group
for providing the base GEOS-Chem model used during our research.
Resources supporting this work were provided by the NASA High-End
Computing (HEC) Program through the NASA Advanced Supercomputing (NAS)
Division at NASA Ames Research Center. B. Gantt is supported by an
appointment to the Research Participation Program at the Office of
Research and Development, US EPA, administered by ORISE.
NR 62
TC 0
Z9 0
U1 6
U2 26
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 3
BP 619
EP 629
DI 10.5194/gmd-8-619-2015
PG 11
WC Geosciences, Multidisciplinary
SC Geology
GA CE9JM
UT WOS:000352160200010
ER
PT J
AU Duan, WL
He, B
Takara, K
Luo, PP
Nover, D
Hu, MC
AF Duan, W. L.
He, B.
Takara, K.
Luo, P. P.
Nover, D.
Hu, M. C.
TI Modeling suspended sediment sources and transport in the Ishikari River
basin, Japan, using SPARROW
SO HYDROLOGY AND EARTH SYSTEM SCIENCES
LA English
DT Article
ID SPATIALLY REFERENCED REGRESSION; GULF-OF-MEXICO; LAND-USE;
WATER-QUALITY; SOIL-EROSION; NITROGEN DELIVERY; PHOSPHORUS; IMPACT;
CHANNEL; RUNOFF
AB It is important to understand the mechanisms that control the fate and transport of suspended sediment (SS) in rivers, because high suspended sediment loads have significant impacts on riverine hydroecology. In this study, the SPARROW (SPAtially Referenced Regression on Watershed Attributes) watershed model was applied to estimate the sources and transport of SS in surface waters of the Ishikari River basin (14 330 km(2)), the largest watershed in Hokkaido, Japan. The final developed SPARROW model has four source variables (developing lands, forest lands, agricultural lands, and stream channels), three landscape delivery variables (slope, soil permeability, and precipitation), two in-stream loss coefficients, including small streams (streams with drainage area < 200 km(2)) and large streams, and reservoir attenuation. The model was calibrated using measurements of SS from 31 monitoring sites of mixed spatial data on topography, soils and stream hydrography. Calibration results explain approximately 96% (R-2) of the spatial variability in the natural logarithm mean annual SS flux (kg yr(-1)) and display relatively small prediction errors at the 31 monitoring stations. Results show that developing land is associated with the largest sediment yield at around 1006 kg km(-2) yr(-1), followed by agricultural land (234 kg km(-2) yr(-1)). Estimation of incremental yields shows that 35% comes from agricultural lands, 23% from forested lands, 23% from developing lands, and 19% from stream channels. The results of this study improve our understanding of sediment production and transportation in the Ishikari River basin in general, which will benefit both the scientific and management communities in safeguarding water resources.
C1 [Duan, W. L.; He, B.] Chinese Acad Sci, Nanjing Inst Geog & Limnol, Key Lab Watershed Geog Sci, Nanjing 210008, Jiangsu, Peoples R China.
[Duan, W. L.; Takara, K.; Hu, M. C.] Kyoto Univ, Disaster Prevent Res Inst, Kyoto, Japan.
[Luo, P. P.] Zhejiang Univ, Coll Civil Engn & Architecture, Inst Hydraul Struct Engn & Water Environm, Hangzhou 310003, Zhejiang, Peoples R China.
[Luo, P. P.] United Nations Univ, Inst Adv Study Sustainabil, Shibuya Ku, Tokyo, Japan.
[Nover, D.] US EPA, Global Change Res Grp, Washington, DC 20010 USA.
RP Duan, WL (reprint author), Chinese Acad Sci, Nanjing Inst Geog & Limnol, Key Lab Watershed Geog Sci, Nanjing 210008, Jiangsu, Peoples R China.
EM duan.scut.cn@gmail.com; hebin@niglas.ac.cn; luoping198121@gmail.com
FU National Natural Science Foundation of China [41471460]; "One Hundred
Talents Program" of Chinese Academy of Sciences; Kyoto University
Sustainability/Survivability Science for a Resilient Society Adaptable
to Extreme Weather Conditions Global COE program; Global Center for
Education and Research on Human Security Engineering for Asian
Megacities; Postdoctoral fellowship of Japan Society for the Promotion
of Science [P12055]; JSPS KAKENHI [24.02055]; JSPS (KAKENHI Wakate B)
[90569724]; China Scholarship Council (CSC)
FX This study is sponsored by National Natural Science Foundation of China
(No. 41471460) and "One Hundred Talents Program" of Chinese Academy of
Sciences, the Kyoto University Sustainability/Survivability Science for
a Resilient Society Adaptable to Extreme Weather Conditions Global COE
program and the Global Center for Education and Research on Human
Security Engineering for Asian Megacities, the Postdoctoral fellowship
of Japan Society for the Promotion of Science (P12055), JSPS KAKENHI
grant number 24.02055 and the JSPS Grant-in-Aid for Young Scientists (B)
(KAKENHI Wakate B, 90569724). We also wish to acknowledge Anne B. Hoos
and John W. Brakebill of the US Geological Survey for their help with
the use of the SPARROW model. The first author would like to thank the
China Scholarship Council (CSC) for his PhD scholarships.
NR 45
TC 4
Z9 4
U1 4
U2 19
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1027-5606
EI 1607-7938
J9 HYDROL EARTH SYST SC
JI Hydrol. Earth Syst. Sci.
PY 2015
VL 19
IS 3
BP 1293
EP 1306
DI 10.5194/hess-19-1293-2015
PG 14
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA CE9JQ
UT WOS:000352160600012
ER
PT J
AU Holeck, KT
Rudstam, LG
Watkins, JM
Luckey, FJ
Lantry, JR
Lantry, BF
Trometer, ES
Koops, MA
Johnson, TB
AF Holeck, K. T.
Rudstam, L. G.
Watkins, J. M.
Luckey, F. J.
Lantry, J. R.
Lantry, B. F.
Trometer, E. S.
Koops, M. A.
Johnson, T. B.
TI Lake Ontario water quality during the 2003 and 2008 intensive field
years and comparison with long-term trends
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE oligotrophication; phosphorus; silica; chlorophyll a; Secchi disc
transparency; trophic state
ID LAURENTIAN GREAT-LAKES; TOTAL PHOSPHORUS; CHLOROPHYLL-A; TROPHIC STATE;
FOOD-WEB; PHYTOPLANKTON; ZOOPLANKTON; NEARSHORE; EUTROPHICATION;
ENRICHMENT
AB Phosphorus loading declined between the 1970s and the 1990s, leading to oligotrophication of the offshore waters of Lake Ontario during that time period. Using lake-wide data from the intensive field years of 2003 and 2008 and from available long-term data sets on several trophic state indicators (total phosphorus [TP], soluble reactive silica [SRSi], chlorophyll a and Secchi disc transparency [SDT]), we tested the hypothesis that oligotrophication of the offshore waters of Lake Ontario has continued in the 2000s. Significant differences between 2003 and 2008 include higher spring (April) TP, SRSi, and SDT in 2008, lower summer (July-August) SDT in 2008, higher summer chlorophyll a in 2008, and lower fall (September) TP, SRSi, and chlorophyll a in 2008. The decline in SRSi from spring to summer was greater in 2008 than in 2003. Change point and regression analyses on the long-term data revealed no trend in spring TP since 1996, in summer chlorophyll a since 1994, in spring SDT since 1998, in spring SRSi or SRSi decline from spring to summer since 1999, or in summer SDT since 2001. Neither the comparison of the 2003 and 2008 surveys nor the analysis of the long-term data supported our hypothesis of continued oligotrophication of the offshore of Lake Ontario in the 2000s.
C1 [Holeck, K. T.; Rudstam, L. G.; Watkins, J. M.] Cornell Univ, Dept Nat Resources, Cornell Biol Field Stn, Bridgeport, NY 13030 USA.
[Luckey, F. J.] US EPA, New York, NY 10007 USA.
[Lantry, J. R.] New York State Dept Environm Conservat, Lake Ontario Fisheries Res Unit, Cape Vincent Fisheries Res Stn, Cape Vincent, NY 13618 USA.
[Lantry, B. F.] US Geol Survey, Great Lakes Sci Ctr, Lake Ontario Biol Stn, Oswego, NY 13126 USA.
[Trometer, E. S.] US Fish & Wildlife Serv, Lower Great Lakes Off, Basom, NY 14013 USA.
[Koops, M. A.] Fisheries & Oceans Canada, Great Lakes Lab Fisheries & Aquat Sci, Burlington, ON L7R 4A6, Canada.
[Johnson, T. B.] Ontario Minist Nat Resources, Glenora Fisheries Stn, Picton, ON K0K 2T0, Canada.
RP Holeck, KT (reprint author), Cornell Univ, Dept Nat Resources, Cornell Biol Field Stn, 900 Shackelton Pt Rd, Bridgeport, NY 13030 USA.
EM kth1@cornell.edu
RI Koops, Marten/A-4534-2010
OI Koops, Marten/0000-0002-3676-7946
FU EPA [97220700-0]; International Joint Commission
FX This work was funded by EPA Grant 97220700-0 to Cornell University as
part of the Great Lakes Restoration Initiative and a grant from the
International Joint Commission. Further support is provided by the
agencies collaborating in the lower trophic level assessments of Lake
Ontario (EPA GNLPO and Region 2, NYSDEC, USGS, USFWS, DFO, EC, OMNR).
NR 44
TC 7
Z9 7
U1 7
U2 24
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1463-4988
EI 1539-4077
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2015
VL 18
IS 1
BP 7
EP 17
DI 10.1080/14634988.2015.1000787
PG 11
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA CE3AI
UT WOS:000351695400003
ER
PT J
AU Rudstam, LG
Holeck, KT
Bowen, KL
Watkins, JM
Weidel, BC
Luckey, FJ
AF Rudstam, L. G.
Holeck, K. T.
Bowen, K. L.
Watkins, J. M.
Weidel, B. C.
Luckey, F. J.
TI Lake Ontario zooplankton in 2003 and 2008: Community changes and
vertical redistribution
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE calanoids; cyclopoids; bosminids; daphniids; Bythotrephes
ID LAURENTIAN GREAT-LAKES; LOWER FOOD-WEB; CLADOCERAN
BYTHOTREPHES-LONGIMANUS; ALEWIFE ALOSA-PSEUDOHARENGUS; WATER
SURVEILLANCE PROGRAM; SMELT OSMERUS-MORDAX; CERCOPAGIS-PENGOI; RAINBOW
SMELT; PREDATORY CLADOCERAN; CRUSTACEAN ZOOPLANKTON
AB Lake-wide zooplankton surveys are critical for documenting and understanding food web responses to ecosystem change. Surveys in 2003 and 2008 during the binational intensive field year in Lake Ontario found that offshore epilimnetic crustacean zooplankton declined by a factor of 12 (density) and factor of 5 (biomass) in the summer with smaller declines in the fall. These declines coincided with an increase in abundance of Bythotrephes and are likely the result of direct predation by, or behavioral responses to this invasive invertebrate predator. Whole water column zooplankton density also declined from 2003 to 2008 in the summer and fall (factor of 4), but biomass only declined in the fall (factor of 2). The decline in biomass was less than the decline in density because the average size of individual zooplankton increased. This was due to changes in the zooplankton community composition from a cyclopoid/bosminid dominated community in 2003 to a calanoid dominated community in 2008. The increase in calanoid copepods was primarily due to the larger species Limnocalanus macrurus and Leptodiaptomus sicilis. These cold water species were found in and below the thermocline associated with a deep chlorophyll layer. In 2008, most of the zooplankton biomass resided in or below the thermocline during the day. Increased importance of copepods in deeper, colder water may favor Cisco and Rainbow Smelt over Alewife because these species are better adapted to cold temperatures than Alewife.
C1 [Rudstam, L. G.; Holeck, K. T.; Watkins, J. M.] Cornell Univ, Dept Nat Resources, Ithaca, NY 14853 USA.
[Rudstam, L. G.; Holeck, K. T.; Watkins, J. M.] Cornell Univ, Cornell Biol Field Stn, Ithaca, NY USA.
[Bowen, K. L.] Dept Fisheries & Oceans Canada, Burlington, ON, Canada.
[Weidel, B. C.] USGS Great Lakes Lab, Lake Ontario Biol Stn, Oswego, NY USA.
[Luckey, F. J.] US EPA, New York, NY USA.
RP Rudstam, LG (reprint author), Cornell Univ, Dept Nat Resources, Fernow Hall, Ithaca, NY 14853 USA.
EM lgr1@cornell.edu
FU EPA [97220700-0]; International Joint Commission
FX This work was funded by EPA Grant 97220700-0 to Cornell University as
part of the Great Lakes Restoration Initiative with supplemental funding
from the International Joint Commission. Further support was provided by
the agencies collaborating in the lower trophic level assessments of
Lake Ontario (EPA GNLPO and Region 2, NYSDEC, USGS, USFWS, DFO, EC,
OMNR). The opinions presented herein are those of the authors and do not
necessarily represent the position of EPA or USGS. This is contribution
number 1863 of the USGS Great Lakes Science Center.
NR 84
TC 6
Z9 6
U1 6
U2 34
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1463-4988
EI 1539-4077
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2015
VL 18
IS 1
BP 43
EP 62
DI 10.1080/14634988.2014.965121
PG 20
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA CE3AI
UT WOS:000351695400006
ER
PT J
AU Xing, J
Mathur, R
Pleim, J
Hogrefe, C
Gan, CM
Wong, DC
Wei, C
Gilliam, R
Pouliot, G
AF Xing, J.
Mathur, R.
Pleim, J.
Hogrefe, C.
Gan, C-M.
Wong, D. C.
Wei, C.
Gilliam, R.
Pouliot, G.
TI Observations and modeling of air quality trends over 1990-2010 across
the Northern Hemisphere: China, the United States and Europe
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID MESOSCALE METEOROLOGICAL MODEL; BLACK CARBON CONCENTRATIONS; ATMOSPHERIC
BOUNDARY-LAYER; LINE OZONE CONCENTRATIONS; FINE PARTICULATE MATTER;
NONLOCAL CLOSURE-MODEL; LAND-SURFACE MODEL; LONG-TERM CHANGES; PART I;
PERFORMANCE EVALUATION
AB Trends in air quality across the Northern Hemisphere over a 21-year period (1990-2010) were simulated using the Community Multiscale Air Quality (CMAQ) multiscale chemical transport model driven by meteorology from Weather Research and Forecasting (WRF) simulations and internally consistent historical emission inventories obtained from EDGAR. Thorough comparison with several ground observation networks mostly over Europe and North America was conducted to evaluate the model performance as well as the ability of CMAQ to reproduce the observed trends in air quality over the past 2 decades in three regions: eastern China, the continental United States and Europe.
The model successfully reproduced the observed decreasing trends in SO2, NO2, 8 h O-3 maxima, SO42- and elemental carbon (EC) in the US and Europe. However, the model fails to reproduce the decreasing trends in NO3- in the US, potentially pointing to uncertainties of NH3 emissions. The model failed to capture the 6-year trends of SO2 and NO2 in CN-API (China - Air Pollution Index) from 2005 to 2010, but reproduced the observed pattern of O-3 trends shown in three World Data Centre for Greenhouse Gases (WDCGG) sites over eastern Asia. Due to the coarse spatial resolution employed in these calculations, predicted SO2 and NO2 concentrations are underestimated relative to all urban networks, i.e., US-AQS (US - ir Quality System; normalized mean bias (NMB) D 38% and 48 %), EU-AIRBASE (European Air quality data Base; NMB D 18 and 54 %) and CN-API (NMB D 36 and 68 %). Conversely, at the rural network EU-EMEP (European Monitoring and Evaluation Programme), SO2 is overestimated (NMB from 4 to 150 %) while NO2 is simulated well (NMB within +/- 15 %) in all seasons. Correlations between simulated and observed O-3 wintertime daily 8 h maxima (DM8) are poor compared to other seasons for all networks. Better correlation between simulated and observed SO42- was found compared to that for SO2. Underestimation of summer SO42- in the US may be associated with the uncertainty in precipitation and associated wet scavenging representation in the model. The model exhibits worse performance for NO3- predictions, particularly in summer, due to high uncertainties in the gas/particle partitioning of NO3- as well as seasonal variations of NH3 emissions. There are high correlations (R > 0.5) between observed and simulated EC, although the model underestimates the EC concentration by 65% due to the coarse grid resolution as well as uncertainties in the PM speciation profile associated with EC emissions.
The almost linear response seen in the trajectory of modeled O-3 changes in eastern China over the past 2 decades suggests that control strategies that focus on combined control of NOx and volatile organic compound (VOC) emissions with a ratio of 0.46 may provide the most effective means for O-3 reductions for the region devoid of nonlinear response potentially associated with NOx or VOC limitation resulting from alternate strategies. The response of O-3 is more sensitive to changes in NOx emissions in the eastern US because the relative abundance of biogenic VOC emissions tends to reduce the effectiveness of VOC controls. Increasing NH3 levels offset the relative effectiveness of NOx controls in reducing the relative fraction of aerosol NO3- formed from declining NOx emissions in the eastern US, while the control effectiveness was assured by the simultaneous control of NH3 emission in Europe.
C1 [Xing, J.; Mathur, R.; Pleim, J.; Hogrefe, C.; Gan, C-M.; Wong, D. C.; Wei, C.; Gilliam, R.; Pouliot, G.] US EPA, Durham, NC 27711 USA.
[Wei, C.] Max Planck Inst Chem, Multiphase Chem Dept, D-55128 Mainz, Germany.
RP Xing, J (reprint author), US EPA, Durham, NC 27711 USA.
EM xing.jia@epa.gov
RI wei, chao/E-4379-2011; Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
FU US Department of Energy [DE-SC000378]; US EPA [RW-89-9233260 1];
National Research Council
FX Although this work has been reviewed and approved for publication by the
US Environmental Protection Agency (EPA), it does not reflect the views
and policies of the agency. This work was supported in part by an
inter-agency agreement between the US Department of Energy project (IA
no. DE-SC000378) and the US EPA (IA no. RW-89-9233260 1). This research
was performed while Jia Xing held a National Research Council Research
Associateship Award at the US EPA. The authors gratefully acknowledge
the free availability and use of data sets associated with the EDGAR,
SMOKE, GEIA, CASTNET, IMPROVE, AQS, EMEP, AIRBASE, WDCGG and China API
initiatives.
NR 80
TC 28
Z9 28
U1 20
U2 104
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 5
BP 2723
EP 2747
DI 10.5194/acp-15-2723-2015
PG 25
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CD6KL
UT WOS:000351197900003
ER
PT J
AU Mukerjee, S
Smith, L
Brantley, H
Stallings, C
Neas, L
Kimbrough, S
Williams, R
AF Mukerjee, Shaibal
Smith, Luther
Brantley, Halley
Stallings, Casson
Neas, Lucas
Kimbrough, Sue
Williams, Ronald
TI Comparison of modeled traffic exposure zones using on-road air pollution
measurements
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Article
DE Air pollution; geographic information system (GIS); mobile monitor;
traffic
ID NEAR-ROAD; RESIDENTIAL PROXIMITY; ULTRAFINE PARTICLES; MAJOR HIGHWAY;
QUALITY; ASTHMA; OUTCOMES; IMPACTS; TRENDS
AB Modeled traffic data were used to develop traffic exposure zones (TEZs) such as traffic delay, high volume, and transit routes in the Research Triangle area of North Carolina (USA). On-road air pollution measurements of nitrogen dioxide (NO2), carbon monoxide (CO), carbon dioxide (CO2), black carbon (BC), coarse (PM2.5-10), fine (PM2.5) particulate matter and ultrafine particles (UFPs) were made on routes that encountered these TEZs. Results indicated overall greater traffic pollutant levels in high volume and delay road sections than bus routes or areas of higher signal light density. The combination of delineating roadways into TEZs with highly time resolved on-road measurements demonstrated how pollutant levels can vary within roadways.
C1 [Mukerjee, Shaibal; Williams, Ronald] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Smith, Luther; Stallings, Casson] Alion Sci & Technol, Durham, NC USA.
[Brantley, Halley; Kimbrough, Sue] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Brantley, Halley] Student Serv Contractor, Res Triangle Pk, NC USA.
[Neas, Lucas] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Mukerjee, S (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM mukerjee.shaibal@epa.gov
OI Kimbrough, Evelyn Sue/0000-0002-7246-0255
FU U.S. Environmental Protection Agency through its Office of Research and
Development [EP-D-10-070]
FX We thank the Institute for Transportation Research and Education at
North Carolina State University for providing modeled traffic counts and
Parikh Deshmukh of ARCADIS for field measurements. We also thank Gayle
Hagler, Carry Croghan, Jason Weinstein, and Eben Thoma of EPA/ORD for
analysis and reviewing the paper. The U.S. Environmental Protection
Agency through its Office of Research and Development funded and managed
the research described here under contract EP-D-10-070 to Alion. The
paper has been subjected to Agency review and approved for publication.
Mention of trade names or commercial products does not constitute an
endorsement or recommendation for use.
NR 24
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PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD JAN
PY 2015
VL 6
IS 1
BP 82
EP 87
DI 10.5094/APR.2015.010
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CE1AJ
UT WOS:000351543300010
ER
PT J
AU Jahne, MA
Rogers, SW
Ramler, IP
Holder, E
Hayes, G
AF Jahne, Michael A.
Rogers, Shane W.
Ramler, Ivan P.
Holder, Edith
Hayes, Gina
TI Hierarchal clustering yields insight into multidrug-resistant bacteria
isolated from a cattle feedlot wastewater treatment system
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Antibiotic resistance; Hierarchal clustering; Animal feeding operations;
Fecal indicator bacteria; Wastewater; Vancomycin
ID ANIMAL FEEDING OPERATIONS; GRAM-POSITIVE BACTERIA; ANTIMICROBIAL
RESISTANCE; ESCHERICHIA-COLI; VANCOMYCIN RESISTANCE;
ANTIBIOTIC-RESISTANCE; ENTEROCOCCUS-FAECALIS; SURFACE-WATER; HUMAN
HEALTH; GENE
AB Forty-two percent of Escherichia coli and 58 % of Enterococcus spp. isolated from cattle feedlot runoff and associated infiltration basin and constructed wetland treatment system were resistant to at least one antibiotic of clinical importance; a high level of multidrug resistance (22 % of E. coli and 37 % of Enterococcus spp.) was observed. Hierarchical clustering revealed a closely associated resistance cluster among drug-resistant E. coli isolates that included cephalosporins (ceftiofur, cefoxitin, and ceftriaxone), aminoglycosides (gentamycin, kanamycin, and amikacin), and quinolone nalidixic acid; antibiotics from these classes were used at the study site, and cross-resistance may be associated with transferrable multiple-resistance elements. For Enterococcus spp., co-resistance among vancomycin, linezolid, and daptomycin was common; these antibiotics are reserved for complicated clinical infections and have not been approved for animal use. Vancomycin resistance (n=49) only occurred when isolates were resistant to linezolid, daptomycin, and all four of the MLSB (macrolide-lincosamide-streptogramin B) antibiotics tested (tylosin, erythromycin, lincomycin, and quinipristin/dalfopristin). This suggests that developing co-resistance to MLSB antibiotics along with cyclic lipopeptides and oxazolidinones may result in resistance to vancomycin as well. Effects of the treatment system on antibiotic resistance were pronounced during periods of no rainfall and low flow (long residence time). Increased hydraulic loading (short residence time) under the influence of rain caused antibiotic-resistant bacteria to be flushed through the treatment system. This presents concern for environmental discharge of multidrug-resistant organisms relevant to public health.
C1 [Jahne, Michael A.] Clarkson Univ, Inst Sustainable Environm, Potsdam, NY 13699 USA.
[Rogers, Shane W.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45212 USA.
[Ramler, Ivan P.] St Lawrence Univ, Dept Math Comp Sci & Stat, Canton, NY 13617 USA.
[Holder, Edith] Pegasus Tech Serv, Cincinnati, OH 45219 USA.
[Hayes, Gina] Miami Univ, Inst Environm & Sustainabil, Oxford, OH 45056 USA.
RP Rogers, SW (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45212 USA.
EM srogers@clarkson.edu
FU National Research Initiative of the USDA Cooperative State Research,
Education, and Extension Service [2007-35102-18614]; U.S. Environmental
Protection Agency through its Office of Research and Development;
National Science Foundation [0959713]
FX This project was supported by the National Research Initiative of the
USDA Cooperative State Research, Education, and Extension Service, grant
number 2007-35102-18614. The U.S. Environmental Protection Agency,
through its Office of Research and Development, also funded and
collaborated in the research described herein. Any opinions expressed in
this paper are those of the authors and do not necessarily reflect the
official positions and policies of the USEPA. Any mention of trade names
or commercial products does not constitute endorsement or recommendation
for use. This material is based, in part, upon work supported by the
National Science Foundation under Grant No. 0959713. The authors thank
Dr. Robert Burns of Iowa State University for installation, calibration,
and maintenance of the sampling equipment and collection and shipment of
manure and water samples. The authors also thank the landowner who
graciously allowed access and collection of samples at the study site.
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
EI 1573-2959
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JAN
PY 2015
VL 187
IS 1
AR 4168
DI 10.1007/s10661-014-4168-9
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CE0XU
UT WOS:000351535000001
PM 25504186
ER
PT J
AU Davis, AY
Ottmar, R
Liu, YQ
Goodrick, S
Achtemeier, G
Gullett, B
Aurell, J
Stevens, W
Greenwald, R
Hu, YT
Russell, A
Hiers, JK
Odman, MT
AF Davis, Aika Y.
Ottmar, Roger
Liu, Yongqiang
Goodrick, Scott
Achtemeier, Gary
Gullett, Brian
Aurell, Johanna
Stevens, William
Greenwald, Roby
Hu, Yongtao
Russell, Armistead
Hiers, J. Kevin
Odman, M. Talat
TI Fire emission uncertainties and their effect on smoke dispersion
predictions: a case study at Eglin Air Force Base, Florida, USA
SO INTERNATIONAL JOURNAL OF WILDLAND FIRE
LA English
DT Article
ID BIOMASS BURNING EMISSIONS; UNITED-STATES; PRESCRIBED BURNS; PLUME-RISE;
CARBON; URBAN; MODEL; SIMULATION; ATMOSPHERE; PARTICLES
AB Prescribed burning is practiced to benefit ecosystems but the resulting emissions can adversely affect air quality. A better understanding of the uncertainties in emission estimates and how these uncertainties affect smoke predictions is critical for model-based decision making. This study examined uncertainties associated with estimating fire emissions and how they affected smoke concentrations downwind from a prescribed burn that was conducted at Eglin Air Force Base in Florida, US. Estimated variables used in the modelled emission calculation were compared with field measurements. Fuel loadings, fuel consumption and emission factors were simulated using Photo Series, Consume, and previously published values. A plume dispersion model was used to study the effect of uncertainty in emissions on ground concentration prediction. The fire emission models predicted fuel loading, fuel consumption and emission factor within 15% of measurements. Approximately 18% uncertainty in field measurements of PM2.5 emissions and 36% uncertainty attributed to variability in emission estimating models resulted respectively in 20% and 42% ground level PM2.5 concentration uncertainties in dispersion modelling using Daysmoke. Uncertainty in input emissions influences the concentrations predicted by the smoke dispersion model to the same degree as does the model's inherent uncertainty due to turbulence.
C1 [Davis, Aika Y.; Hu, Yongtao; Russell, Armistead; Odman, M. Talat] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Ottmar, Roger] US Forest Serv, USDA, Pacific NW Res Stn, Pacific Wildland Fire Sci Lab, Seattle, WA 98103 USA.
[Liu, Yongqiang; Goodrick, Scott; Achtemeier, Gary] US Forest Serv, USDA, Southern Res Stn, Forestry Sci Lab, Athens, GA 30602 USA.
[Gullett, Brian; Aurell, Johanna] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Stevens, William] Kentucky Christian Univ, Grayson, KY 41143 USA.
[Greenwald, Roby] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Hiers, J. Kevin] Univ South, Environm Stewardship & Sustainabil, Sewanee, TN 37383 USA.
RP Odman, MT (reprint author), Georgia Inst Technol, Sch Civil & Environm Engn, 790 Atlantic Dr, Atlanta, GA 30332 USA.
EM talat.odman@ce.gatech.edu
RI Hu, Yongtao/H-7543-2016
OI Hu, Yongtao/0000-0002-5161-0592
FU Joint Fire Science Program [JFSP 081604, JFSP 081606]; Strategic
Environmental Research and Development Program [SERDP RC-1647]; NASA Air
Quality Applied Science Team [NNX11AI55G]; US EPA Science to Achieve
Results Program [RD83521701]
FX This study was made possible with support from the Joint Fire Science
Program (JFSP 081604 and JFSP 081606), the Strategic Environmental
Research and Development Program (SERDP RC-1647) and NASA Air Quality
Applied Science Team (NNX11AI55G). This publication was made possible
also by the US EPA Science to Achieve Results Program (RD83521701). Its
contents are solely the responsibility of the grantee and do not
necessarily represent the official views of the US EPA. Further, US EPA
does not endorse the purchase of any commercial products or services
mentioned in the publication. Special thanks are due to those who
participated in Rx-CADRE at Eglin AFB and helped gathering burn
information and data, especially Brett Williams from Jackson Guard,
Eglin AFB Fire Management, and Boris Galvis and Fernando Garcia-Menendez
from Georgia Institute of Technology. We also acknowledge David Combs
and Ken Forbus from USDA Forest Service for conduction ceilometer
measurements, as well as Chris Pressley, Bill Mitchell and Bill Squier
of EPA and Rob Gribble of ISSI Inc. for conducting aerostat
measurements.
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PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
3168, AUSTRALIA
SN 1049-8001
EI 1448-5516
J9 INT J WILDLAND FIRE
JI Int. J. Wildland Fire
PY 2015
VL 24
IS 2
BP 276
EP 285
DI 10.1071/WF13071
PG 10
WC Forestry
SC Forestry
GA CD9TX
UT WOS:000351442500014
ER
PT J
AU Moore, C
AF Moore, Chris
TI Welfare Estimates of Avoided Ocean Acidification in the US Mollusk
Market
SO JOURNAL OF AGRICULTURAL AND RESOURCE ECONOMICS
LA English
DT Article
DE compensating surplus; equivalent surplus; inverse demand system; ocean
acidification
ID INVERSE DEMAND SYSTEMS; DISTANCE FUNCTION; FISH; CO2
AB Ocean acidification has the potential to adversely affect a number of valuable marine ecosystem services by making it more difficult, and eventually impossible, for many marine organisms to form shells and skeletons. Reef-forming corals, commercially valuable shellfish, and primary producers that form the base of the marine food web are among the affected organisms. Despite the range and magnitude of likely impacts, very few economic analyses of ocean acidification's consequences have been conducted. This paper adds to the emerging body of literature by taking a distance function approach to estimating the benefits of avoided ocean acidification in the U.S. mollusk market. A nonlinear inverse almost ideal demand system estimates the utility parameters needed to calculate the exact consumer welfare measures compensating and equivalent surplus for two hypothetical policies that would reduce global greenhouse gas emissions relative to a business-as-usual scenario.
C1 US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Moore, C (reprint author), US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
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PU WESTERN AGRICULTURAL ECONOMICS ASSOC
PI LOGAN
PA C/O DEEVON BAILEY, UTAH STATE UNIV, ECONOMICS DEPT, 3535 OLD MAIN HILL,
LOGAN, UT 84322-3530 USA
SN 1068-5502
J9 J AGR RESOUR ECON
JI J. Agric. Resour. Econ.
PD JAN
PY 2015
VL 40
IS 1
BP 50
EP 62
PG 13
WC Agricultural Economics & Policy; Economics
SC Agriculture; Business & Economics
GA CE0EP
UT WOS:000351477600005
ER
PT J
AU Milovancev, M
Hauck, M
Keller, C
Stranahan, LW
Mansoor, A
Malarkey, DE
AF Milovancev, M.
Hauck, M.
Keller, C.
Stranahan, L. W.
Mansoor, A.
Malarkey, D. E.
TI Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of
Human Non-rhabdomyosarcoma Soft Tissue Sarcomas
SO JOURNAL OF COMPARATIVE PATHOLOGY
LA English
DT Article
DE comparative pathology; dog; man; soft tissue sarcoma
ID DRUG DEVELOPMENT; DOGS; TUMORS; TARGETS; BIOLOGY
AB Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour specimens by board-certified veterinary and medical pathologists, both blinded to the other's interpretations. Comparison between the veterinary and human diagnoses revealed a generally consistent pattern of interpretation with few notable variations. Most tumours (13/32) were judged to display similar histomorphological appearance to human low-grade spindle cell sarcomas, appearing non-distinctive and morphologically of a fibroblastic/myofibroblastic type. Five canine cases resembled human liposarcoma, but with atypical desmin-positive epithelioid cells present. Five canine cases resembled human spindle cell sarcoma with myxoid features and two additional cases resembled human myxofibrosarcoma. Seven canine cases were noted to resemble human undifferentiated sarcoma. Findings in the present study demonstrate that canine STSs display histological and immunohistochemical features similar to their human equivalents. Because of these cross-species similarities, a particular opportunity exists to understand the biology and treatment of human STS by potentially including dogs as clinical models. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Milovancev, M.] Oregon State Univ, Dept Clin Sci, Corvallis, OR 97331 USA.
[Hauck, M.; Stranahan, L. W.] N Carolina State Univ, Dept Clin Sci, Raleigh, NC 27695 USA.
[Keller, C.] Oregon Hlth & Sci Univ, Dept Pediat, Pape Family Pediat Res Inst, Pediat Canc Biol Program, Portland, OR 97201 USA.
[Mansoor, A.] Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA.
[Malarkey, D. E.] Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, Res Triangle Pk, NC USA.
[Keller, C.] Childrens Canc Therapy Dev Inst, Ft Collins, CO 80524 USA.
RP Milovancev, M (reprint author), Oregon State Univ, Dept Clin Sci, Corvallis, OR 97331 USA.
EM milan.milovancev@oregonstate.edu
OI Milovancev, Milan/0000-0002-0556-4409
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9975
EI 1532-3129
J9 J COMP PATHOL
JI J. Comp. Pathol.
PD JAN
PY 2015
VL 152
IS 1
BP 22
EP 27
DI 10.1016/j.jcpa.2014.09.005
PG 6
WC Pathology; Veterinary Sciences
SC Pathology; Veterinary Sciences
GA CD2OX
UT WOS:000350920000004
PM 25435513
ER
PT J
AU Selvakumar, A
Matthews, JC
Condit, W
Sterling, R
AF Selvakumar, Ariamalar
Matthews, John C.
Condit, Wendy
Sterling, Ray
TI Innovative research program on the renewal of aging water infrastructure
systems
SO JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA
LA English
DT Article
DE decision support; pipe rehabilitation; quality assurance/quality
control; trenchless technology; wastewater pipe; water pipe
ID REHABILITATION; SEWER; MAINS
AB The needs associated with the aging water infrastructure are immense and have been estimated at more than $1 trillion over the next 20 years for water and wastewater utilities. To meet this growing need, utilities require the use of innovative technologies and procedures for managing their systems. To help meet their needs, the U.S. Environmental Protection Agency initiated a research program to assist utilities in the renewal of water distribution and wastewater collection systems and this paper summarizes that program. This paper addresses the state-of-the-art review of current and emerging renewal technologies available for water distribution and wastewater collection systems. This paper also discusses the results of other program components which are intended to aid in the use of the renewal methods. This included: a cured-in-place pipe retrospective study of liners in use for more than 25 years; a field demonstration program of innovative water rehabilitation methods; a review of quality assurance and quality control measures for trenchless technologies; and current decision-making models and methodologies available to support rehabilitation versus replacement decisions.
C1 [Selvakumar, Ariamalar] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Water Supply & Water Resources Div,Urban Watershe, Edison, NJ 08837 USA.
[Matthews, John C.] Battelle Mem Inst, Baton Rouge, LA 70808 USA.
[Condit, Wendy] Battelle Mem Inst, Columbus, OH 43201 USA.
[Sterling, Ray] Louisiana Tech Univ, Ruston, LA 71272 USA.
RP Selvakumar, A (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Water Supply & Water Resources Div,Urban Watershe, 2890 Woodbridge Ave,MS-104, Edison, NJ 08837 USA.
EM selvakumar.ariamalar@epa.gov
OI Sterling, Raymond/0000-0003-0587-9459
FU U.S. EPA, through its Office of Research and Development
FX The U.S. EPA, through its Office of Research and Development, funded and
managed, or partially funded and collaborated in, the research described
herein. It has been subjected to the Agency's peer and administrative
review and has been approved for external publication. Any opinions
expressed in this paper are those of the authors and do not necessarily
reflect the views of the Agency, therefore, no official endorsement
should be inferred. Any mention of trade names or commercial products
does not constitute endorsement or recommendation for use.
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PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0003-7214
EI 1365-2087
J9 J WATER SUPPLY RES T
JI J. Water Supply Res Technol.-Aqua
PY 2015
VL 64
IS 2
BP 117
EP 129
DI 10.2166/aqua.2014.103
PG 13
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA CC3XA
UT WOS:000350283300001
ER
PT J
AU Puchalski, MA
Rogers, CM
Baumgardner, R
Mishoe, KP
Price, G
Smith, MJ
Watkins, N
Lehmann, CM
AF Puchalski, Melissa A.
Rogers, Christopher M.
Baumgardner, Ralph
Mishoe, Kevin P.
Price, Garry
Smith, Michael J.
Watkins, Nealson
Lehmann, Christopher M.
TI A statistical comparison of active and passive ammonia measurements
collected at Clean Air Status and Trends Network (CASTNET) sites
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID UNITED-STATES; ATMOSPHERIC AMMONIA; AMBIENT AMMONIA; DRY DEPOSITION;
SULFUR-DIOXIDE; NITROGEN; MODEL; NH3; VEGETATION; EMISSIONS
AB Atmospheric concentrations of ammonia (NH3) are not well characterized in the United States due to the sparse number of monitors, the relatively short lifetime of NH3 in the atmosphere, and the difficulty in measuring non-point source emissions such as fertilized agricultural land. In this study, we compare measured weekly concentrations of NH3 collected by two denuder systems with a bi-weekly passive NH3 sampler used by the National Atmospheric Deposition Program's (NADP) Ammonia Monitoring Network (AMoN). The purpose of the study was to verify the passive samplers used by AMoN and characterize any uncertainties introduced when using a bi-weekly versus weekly sampling time period. The study was conducted for 1 year at five remote Clean Air Status and Trends Network (CASTNET) sites. Measured ambient NH3 concentrations ranged from 0.03 mu g NH3 m(-3) to 4.64 mu g NH3 m(-3) in upstate New York and northwest Texas, respectively, while dry deposition estimates ranged from 0.003 kg N ha(-1) wk(-1) to 0.47 kg N ha(-1) wk(-1). Results showed that the bi-weekly passive samplers performed well compared to annular denuder systems (ADS) deployed at each of the five CASTNET sites, while the MetOne Super SASS Mini-Parallel Plate Denuder System (MPPD) was biased low when compared to the ADS. The mean relative percent difference (MRPD) between the ADS and MPPD and the ADS and AMoN sampler was -38% and -9%, respectively. Precision of the ADS and MPPD was 5% and 13%, respectively, while the precision of the passive samplers was 5%. The results of this study demonstrate that the NH3 concentrations measured by AMoN are comparable to the ADS and may be used to supplement the high-time resolution measurements to gain information on spatial gradients of NH3, long-term trends and seasonal variations in NH3 concentrations.
C1 [Puchalski, Melissa A.] US EPA, Off Air Programs, Washington, DC 20460 USA.
[Rogers, Christopher M.; Mishoe, Kevin P.; Price, Garry; Smith, Michael J.] AMEC Environm & Infrastruct Inc, Newberry, FL 32669 USA.
[Baumgardner, Ralph] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[Watkins, Nealson] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27709 USA.
[Lehmann, Christopher M.] Illinois State Water Survey, Cent Analyt Lab, Natl Atmospher Deposit Program, Champaign, IL 61820 USA.
RP Puchalski, MA (reprint author), US EPA, Off Air Programs, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM Puchalski.Melissa@epa.gov
FU U.S. Environmental Protection Agency through Office of Air Programs
[EP-W-09-028]; U.S. Environmental Protection Agency through Office of
Air Quality Planning and Standards [EP-W-09-028]; U.S. Environmental
Protection Agency through Office of Research and Development under EPA
[EP-W-09-028]
FX This work was funded by the U.S. Environmental Protection Agency through
its Office of Air Programs, Office of Air Quality Planning and
Standards, and Office of Research and Development under EPA contract
EP-W-09-028. This document has been reviewed in accordance with U.S.
Environmental Protection Agency policy and approved for publication.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
NR 44
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U1 0
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 2
BP 358
EP 369
DI 10.1039/c4em00531g
PG 12
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CB5WM
UT WOS:000349698500011
PM 25574663
ER
PT J
AU Kulkarni, S
Sobhani, N
Miller-Schulze, JP
Shafer, MM
Schauer, JJ
Solomon, PA
Saide, PE
Spak, SN
Cheng, YF
van der Gon, HACD
Lu, Z
Streets, DG
Janssens-Maenhout, G
Wiedinmyer, C
Lantz, J
Artamonova, M
Chen, B
Imashev, S
Sverdlik, L
Deminter, JT
Adhikary, B
D'Allura, A
Wei, C
Carmichael, GR
AF Kulkarni, S.
Sobhani, N.
Miller-Schulze, J. P.
Shafer, M. M.
Schauer, J. J.
Solomon, P. A.
Saide, P. E.
Spak, S. N.
Cheng, Y. F.
van der Gon, H. A. C. Denier
Lu, Z.
Streets, D. G.
Janssens-Maenhout, G.
Wiedinmyer, C.
Lantz, J.
Artamonova, M.
Chen, B.
Imashev, S.
Sverdlik, L.
Deminter, J. T.
Adhikary, B.
D'Allura, A.
Wei, C.
Carmichael, G. R.
TI Source sector and region contributions to BC and PM2.5 in Central Asia
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID TERM CLIMATE-CHANGE; AIR-QUALITY; CARBONACEOUS AEROSOL; HUMAN HEALTH;
PLUME RISE; EMISSIONS; MODEL; DISTRIBUTIONS; TRANSPORT; INCLUSION
AB Particulate matter (PM) mass concentrations, seasonal cycles, source sector, and source region contributions in Central Asia (CA) are analyzed for the period April 2008-July 2009 using the Sulfur Transport and dEposition Model (STEM) chemical transport model and modeled meteorology from the Weather Research and Forecasting (WRF) model. Predicted aerosol optical depth (AOD) values (annual mean value similar to 0.2) in CA vary seasonally, with lowest values in the winter. Surface PM2.5 concentrations (annual mean value similar to 10 mu g m(3)) also exhibit a seasonal cycle, with peak values and largest variability in the spring/summer, and lowest values and variability in the winter (hourly values from 2 to 90 mu g m(3)). Surface concentrations of black carbon (BC) (mean value similar to 0.1 mu g m(-3)) show peak values in the winter. The simulated values are compared to surface measurements of AOD as well as PM2.5, PM10, BC, and organic carbon (OC) mass concentrations at two regional sites in Kyrgyzstan (Lidar Station Teplokluchenka (LST) and Bishkek). The predicted values of AOD and PM mass concentrations and their seasonal cycles are fairly well captured. The carbonaceous aerosols are underpredicted in winter, and analysis suggests that the winter heating emissions are underestimated in the current inventory.
Dust, from sources within and outside CA, is a significant component of the PM mass and drives the seasonal cycles of PM and AOD. On an annual basis, the power and industrial sectors are found to be the most important contributors to the anthropogenic portion of PM2.5. Residential combustion and transportation are shown to be the most important sectors for BC. Biomass burning within and outside the region also contributes to elevated PM and BC concentrations. The analysis of the transport pathways and the variations in particulate matter mass and composition in CA demonstrates that this region is strategically located to characterize regional and intercontinental transport of pollutants. Aerosols at these sites are shown to reflect dust, biomass burning, and anthropogenic sources from Europe; South, East, and Central Asia; and Russia depending on the time period.
Simulations for a reference 2030 emission scenario based on pollution abatement measures already committed to in current legislation show that PM2.5 and BC concentrations in the region increase, with BC growing more than PM2.5 on a relative basis. This suggests that both the health impacts and the climate warming associated with these particles may increase over the next decades unless additional control measures are taken. The importance of observations in CA to help characterize the changes that are rapidly taking place in the region are discussed.
C1 [Kulkarni, S.; Sobhani, N.; Saide, P. E.; Spak, S. N.; Cheng, Y. F.; Adhikary, B.; Wei, C.; Carmichael, G. R.] Univ Iowa, Ctr Global & Reg Environm Res, Iowa City, IA 52242 USA.
[Sobhani, N.; Carmichael, G. R.] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA.
[Miller-Schulze, J. P.; Shafer, M. M.; Schauer, J. J.; Deminter, J. T.] Wisconsin State Lab Hyg, Madison, WI 53718 USA.
[Miller-Schulze, J. P.; Shafer, M. M.; Schauer, J. J.] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI 53706 USA.
[Solomon, P. A.] US EPA, Off Res & Dev, Las Vegas, NV 89193 USA.
[Spak, S. N.; Lu, Z.] Univ Iowa, Publ Policy Ctr, Iowa City, IA 52242 USA.
[van der Gon, H. A. C. Denier] TNO, NL-3584 CB Utrecht, Netherlands.
[Streets, D. G.] Argonne Natl Lab, Decis & Informat Sci Div, Argonne, IL 60439 USA.
[Janssens-Maenhout, G.] European Commiss, Joint Res Ctr, IES, I-21027 Ispra, Italy.
[Wiedinmyer, C.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Lantz, J.] US EPA, Off Radiat & Indoor Air, Las Vegas, NV 89193 USA.
[Artamonova, M.] Russian Acad Sci, Inst Atmospher Phys, Moscow 109017, Russia.
[Chen, B.; Imashev, S.; Sverdlik, L.] Kyrgyz Russian Slav Univ, Bishkek 720000, Kyrgyzstan.
[D'Allura, A.] ARIANET, I-20128 Milan, Italy.
RP Sobhani, N (reprint author), Univ Iowa, Ctr Global & Reg Environm Res, Iowa City, IA 52242 USA.
EM negin-sobhani@uiowa.edu; gcarmich@engineering.uiowa.edu
RI Spak, Scott/B-7331-2008; wei, chao/E-4379-2011; Imashev,
Sanjar/I-7667-2016; Cheng, Yafang/F-9362-2010
OI Spak, Scott/0000-0002-8545-1411; Imashev, Sanjar/0000-0003-3293-3764;
Cheng, Yafang/0000-0003-4912-9879
FU US Environmental Protection Agency through its Office of Research and
Development; International Science & Technology Center (ISTC) [3715];
EPA [RD-83503701-0]; NASA [NNX08AH56G]; NSF [1049140]; NCRR
[UL1RR024979]; Fulbright-CONICYT [15093810]
FX The US Environmental Protection Agency through its Office of Research
and Development funded this study and collaborated in the research
described here as a component of the International Science & Technology
Center (ISTC) project no. 3715 (Transcontinental Transport of Air
Pollution from Central Asia to the US). The University of Iowa
activities were also supported in part by the following grants: EPA
(RD-83503701-0), NASA (NNX08AH56G), NSF (1049140), NCRR (UL1RR024979),
and Fulbright-CONICYT (15093810). The contents of this study are solely
the responsibility of the authors and do not necessarily represent the
official views of the funding institutions. This manuscript has been
subjected to US EPA review and approved for publication. We thank all
the PIs and their staff for establishing and maintaining the AERONET
sites that have been used in this study. We would also like to
acknowledge the Network Center for EANET and the EMEP Chemical
Coordinating Centre for the PM10 measurements used in this
study.
NR 39
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Z9 4
U1 3
U2 39
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 4
BP 1683
EP 1705
DI 10.5194/acp-15-1683-2015
PG 23
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CB7IP
UT WOS:000349800500008
ER
PT J
AU Almand-Hunter, BB
Walker, JT
Masson, NP
Hafford, L
Hannigan, MP
AF Almand-Hunter, B. B.
Walker, J. T.
Masson, N. P.
Hafford, L.
Hannigan, M. P.
TI Development and validation of inexpensive, automated, dynamic flux
chambers
SO ATMOSPHERIC MEASUREMENT TECHNIQUES
LA English
DT Article
ID GASEOUS DRY DEPOSITION; NITRIC-OXIDE EMISSION; NITROGEN-DIOXIDE NO2;
AIR-QUALITY MODELS; GAS-EXCHANGE; MANAGEMENT STRATEGIES; REACTIVE
NITROGEN; OZONE FLUX; SURFACE; SOIL
AB We developed and validated an automated, inexpensive, and continuous multiple-species gas-flux monitoring system that can provide data for a variety of relevant atmospheric pollutants, including O-3, CO2, and NOx. Validation consisted of conducting concurrent gas-phase dry-deposition experiments, using both dynamic flux chambers and an eddy-covariance system, in a grassy clearing in the Duke Forest (Chapel Hill, NC). Experiments were carried out in June and September under a variety of meteorological conditions. Ozone-deposition measurements from the two methods matched very well (4-10% difference in mean flux rate) when the leaf-area index (LAI) inside the chambers was representative of the average LAI in the field. The dynamic flux chambers can be considered an accurate measurement system under these conditions.
C1 [Almand-Hunter, B. B.; Masson, N. P.; Hafford, L.; Hannigan, M. P.] Univ Colorado, Dept Mech Engn, Boulder, CO 80303 USA.
[Walker, J. T.] US EPA, Air Pollut Prevent & Control Div, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Almand-Hunter, BB (reprint author), Univ Colorado, Dept Mech Engn, 427 UCB, Boulder, CO 80303 USA.
EM berkeley.almand@colorado.edu
FU Electric Power Research Institute (EPRI)
FX We are grateful for the opportunity to do this work, which was funded by
the Electric Power Research Institute (EPRI). We would like to thank
Corey Miller for his help building the flux chambers. We would like to
thank Peter Hamlington, Nick Clements, Bill Mitchell, and Andrew
Turnipseed for helpful discussions. This project would not have been
possible without equipment borrowed from Christine Wiedinmyer and John
Ortega, at the National Center for Atmospheric Research, as well as
Joanna Gordon and Ashley Collier. Ricardo Piedrahita and Nick Masson's
sensor work is the basis for the inexpensive sensor portion of this
project.
NR 55
TC 3
Z9 3
U1 4
U2 12
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1867-1381
EI 1867-8548
J9 ATMOS MEAS TECH
JI Atmos. Meas. Tech.
PY 2015
VL 8
IS 1
BP 267
EP 280
DI 10.5194/amt-8-267-2015
PG 14
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CA5WD
UT WOS:000348977600018
ER
PT J
AU Perez, CM
Hazari, MS
Farraj, AK
AF Perez, Christina M.
Hazari, Mehdi S.
Farraj, Aimen K.
TI Role of Autonomic Reflex Arcs in Cardiovascular Responses to Air
Pollution Exposure
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE C fibers; RARs; SARs; Baroreceptors; Carotid body; Air pollution
ID HEART-RATE-VARIABILITY; SPONTANEOUSLY HYPERTENSIVE-RATS; RESPIRATORY
SINUS ARRHYTHMIA; RAPIDLY ADAPTING RECEPTORS; INFANT-DEATH-SYNDROME;
BAROREFLEX SENSITIVITY; PARTICULATE MATTER; BLOOD-PRESSURE;
CAROTID-BODY; MYOCARDIAL-INFARCTION
AB The body responds to environmental stressors by triggering autonomic reflexes in the pulmonary receptors, baroreceptors, and chemoreceptors to maintain homeostasis. Numerous studies have shown that exposure to various gases and airborne particles can alter the functional outcome of these reflexes, particularly with respect to the cardiovascular system. Modulation of autonomic neural input to the heart and vasculature following direct activation of sensory nerves in the respiratory system, elicitation of oxidative stress and inflammation, or through other mechanisms is one of the primary ways that exposure to air pollution affects normal cardiovascular function. Any homeostatic process that utilizes the autonomic nervous system to regulate organ function might be affected. Thus, air pollution and other inhaled environmental irritants have the potential to alter both local airway function and baro- and chemoreflex responses, which modulate autonomic control of blood pressure and detect concentrations of key gases in the body. While each of these reflex pathways causes distinct responses, the systems are heavily integrated and communicate through overlapping regions of the brainstem to cause global effects. This short review summarizes the function of major pulmonary sensory receptors, baroreceptors, and carotid body chemoreceptors and discusses the impacts of air pollution exposure on these systems.
C1 [Perez, Christina M.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
[Hazari, Mehdi S.; Farraj, Aimen K.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA.
RP Perez, CM (reprint author), Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
EM clamb@email.unc.edu
FU NIEHS NIH HHS [T32 ES007126]
NR 104
TC 6
Z9 6
U1 1
U2 10
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD JAN
PY 2015
VL 15
IS 1
BP 69
EP 78
DI 10.1007/s12012-014-9272-0
PG 10
WC Cardiac & Cardiovascular Systems; Toxicology
SC Cardiovascular System & Cardiology; Toxicology
GA CB1UA
UT WOS:000349412300008
PM 25123706
ER
PT J
AU Baig, RBN
Vaddula, BR
Nadagouda, MN
Varma, RS
AF Baig, R. B. Nasir
Vaddula, Buchi Reddy
Nadagouda, Mallikarjuna N.
Varma, Rajender S.
TI The copper-nicotinamide complex: sustainable applications in coupling
and cycloaddition reactions
SO GREEN CHEMISTRY
LA English
DT Article
ID RECYCLABLE HETEROGENEOUS CATALYST; ARYL HALIDES; SUPPORTED COPPER;
NICKEL-CATALYST; BOND FORMATION; C-N; POTENT; CHEMISTRY; PALLADIUM;
CHITOSAN
AB The crystalline copper(II)-nicotinamide complex, synthesized via simple mixing of copper chloride and nicotinamide solution at room temperature, catalyzes the C-S, C-N bond forming and cycloaddition reactions under a variety of sustainable reaction conditions.
C1 [Baig, R. B. Nasir; Vaddula, Buchi Reddy; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Nadagouda, Mallikarjuna N.] US EPA, WQMB, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Baig, RBN (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA.
EM nadagouda.mallikarjuna@epa.gov; Varma.Rajender@epa.gov
FU appointment to the Research Participation Program for the U.S.
Environmental Protection Agency, Office of Research and Development
FX R. B. Nasir Baig and B. R. Vaddula were supported in part by an
appointment to the Research Participation Program for the U.S.
Environmental Protection Agency, Office of Research and Development,
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and the EPA.
NR 37
TC 4
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U1 2
U2 12
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PY 2015
VL 17
IS 2
BP 1243
EP 1248
DI 10.1039/c4gc02047b
PG 6
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA CB0KQ
UT WOS:000349315200067
ER
PT J
AU Wood, JP
Clayton, MJ
McArthur, T
Serre, SD
Mickelsen, L
Touati, A
AF Wood, Joseph P.
Clayton, Mathew J.
McArthur, Timothy
Serre, Shannon D.
Mickelsen, Leroy
Touati, Abderrahmane
TI Capture of methyl bromide emissions with activated carbon following the
fumigation of a small building contaminated with a Bacillus anthracis
spore simulant
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID ADSORPTION
AB A wide-area Bacillus anthracis spore contamination incident will present immense challenges related to decontamination capacity. For this reason, fumigation with methyl bromide (MeBr) has been proposed as a potential remediation option. Although a few bench-scale laboratory studies have been conducted to evaluate activated carbon for the capture of MeBr, these studies were conducted at conditions replicating commodity fumigation using relatively low MeBr concentrations, temperatures, and/or relative humidity (RH) levels. The more rigorous MeBr fumigation requirements to fully inactivate B. anthracis spores are much more of a challenge for an activated carbon system (ACS) to capture MeBr, and warrant their own investigation. Further, while the aforementioned studies have shown activated carbon to be a possible option for the capture of MeBr in gas streams, these tests were conducted at laboratory bench scale, and thus lack operational perspective and data. Thus, we present for the first time the results of a full-scale study to evaluate an ACS employed for the capture of MeBr at conditions that would be used for decontaminating a building structure contaminated with B. anthracis spores. Airflow rate, temperature, RH, and MeBr levels were measured within the ACS during its operation. Despite the relatively high humidity, temperature, and MeBr levels, the MeBr capture efficiency of the ACS was demonstrated to be more than 99%. The concentration of MeBr exhausted from the structure was reduced from 41,000 to 136 ppmv in 3.5 hr, corresponding to an overall atmospheric emission rate of less than 2 kg. The practical adsorption rate of the ACS was determined to be 4.83 kg MeBr/100 kg carbon. The information and data presented here will facilitate future use of this technology when fumigating with MeBr.
C1 [Wood, Joseph P.; Serre, Shannon D.; Mickelsen, Leroy] US EPA, Res Triangle Pk, NC 27711 USA.
[Clayton, Mathew J.; McArthur, Timothy; Touati, Abderrahmane] ARCADIS US Inc, Durham, NC USA.
RP Wood, JP (reprint author), US EPA, 109 TW Alexander Dr,MC E343-06, Res Triangle Pk, NC 27711 USA.
EM wood.joe@epa.gov
OI Wood, Joseph/0000-0001-6316-9418
FU U.S. Environmental Protection Agency, through its Office of Research and
Development's National Homeland Security Research Center [EP-C-09-027];
ARCADIS US, Inc.
FX The U.S. Environmental Protection Agency, through its Office of Research
and Development's National Homeland Security Research Center, funded and
directed this work through contract EP-C-09-027 with ARCADIS US, Inc.
NR 14
TC 2
Z9 2
U1 2
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PY 2015
VL 65
IS 2
BP 145
EP 153
DI 10.1080/10962247.2014.980017
PG 9
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CA2KP
UT WOS:000348737800004
PM 25947050
ER
PT J
AU Gocht, T
Berggren, E
Ahr, HJ
Cotgreave, I
Cronin, MTD
Daston, G
Hardy, B
Heinzle, E
Hescheler, J
Knight, DJ
Mahony, C
Peschanski, M
Schwarz, M
Thomas, RS
Verfaillie, C
White, A
Whelan, M
AF Gocht, Tilman
Berggren, Elisabet
Ahr, Hans Juergen
Cotgreave, Ian
Cronin, Mark T. D.
Daston, George
Hardy, Barry
Heinzle, Elmar
Hescheler, Juergen
Knight, Derek J.
Mahony, Catherine
Peschanski, Marc
Schwarz, Michael
Thomas, Russell S.
Verfaillie, Catherine
White, Andrew
Whelan, Maurice
TI The SEURAT-1 Approach towards Animal Free Human Safety Assessment
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Article
DE alternatives to animal testing; integrated testing strategy;
mode-of-action theory; proof-of-concept case studies; safety assessment
ID INTEGRATED TESTING STRATEGIES; ALTERNATIVE NONANIMAL METHODS; ADVERSE
OUTCOME PATHWAYS; STRESS-RESPONSE PATHWAYS; RISK-ASSESSMENT;
READ-ACROSS; IN-VITRO; TOXICITY; TOXICOLOGY; FRAMEWORK
AB SEURAT-1 is a European public-private research consortium that is working towards animal-free testing of chemical compounds and the highest level of consumer protection. A research strategy was formulated based on the guiding principle to adopt a toxicological mode-of-action framework to describe how any substance may adversely affect human health. The proof of the initiative will be in demonstrating the applicability of the concepts on which SEURAT-1 is built on three levels: (i) Theoretical prototypes for adverse outcome pathways are formulated based on knowledge already available in the scientific literature on investigating the toxicological modes-of-action leading to adverse outcomes (addressing mainly liver toxicity); (ii) adverse outcome pathway descriptions are used as a guide for the formulation of case studies to further elucidate the theoretical model and to develop integrated testing strategies for the prediction of certain toxicological effects (i.e., those related to the adverse outcome pathway descriptions); (iii) further case studies target the application of knowledge gained within SEURAT-1 in the context of safety assessment. The ultimate goal would be to perform ab initio predictions based on a complete understanding of toxicological mechanisms. In the near-term, it is more realistic that data from innovative testing methods will support read-across arguments. Both scenarios are addressed with case studies for improved safety assessment. A conceptual framework for a rational integrated assessment strategy emerged from designing the case studies and is discussed in the context of international developments focusing on alternative approaches for evaluating chemicals using the new 21st century tools for toxicity testing.
C1 [Gocht, Tilman; Schwarz, Michael] Univ Tubingen, Univ Hosp, Inst Expt & Clin Pharmacol & Toxicol, D-72074 Tubingen, Germany.
[Berggren, Elisabet; Whelan, Maurice] IHCP, JRC, European Commiss, Ispra, Italy.
[Berggren, Elisabet; Whelan, Maurice] EU Reference Lab Alternat Anim Testing EURL ECVAM, Ispra, Italy.
[Ahr, Hans Juergen] Bayer AG, Dept Mol & Genet Toxicol, Wuppertal, Germany.
[Cotgreave, Ian] Swedish Toxicol Sci, Res Ctr Swetox, Sodertalje, Sweden.
[Cotgreave, Ian] Karolinska Inst, Inst Environm Med, Solna, Sweden.
[Cronin, Mark T. D.] Liverpool John Moores Univ, Sch Pharm & Chem, Liverpool L3 3AF, Merseyside, England.
[Daston, George] Procter & Gamble, Product Safety & Regulatory Affairs, Cincinnati, OH USA.
[Hardy, Barry] Douglas Connect, Zeiningen, Switzerland.
[Heinzle, Elmar] Univ Saarland, Saarbrucken, Germany.
[Hescheler, Juergen] Univ Hosp Cologne, Inst Neurophysiol, Cologne, Germany.
[Knight, Derek J.] European Chem Agcy, Helsinki, Finland.
[Mahony, Catherine] Procter & Gamble, Cent Product Safety Dept, London, England.
[Peschanski, Marc] I STEM AFM, INSERM UEVE 861, Evry, France.
[Thomas, Russell S.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Verfaillie, Catherine] Katholieke Univ Leuven, Interdept Stem Cell Inst, Leuven, Belgium.
[White, Andrew] Unilever, Safety & Environm Assurance Ctr, Bedford, England.
RP Gocht, T (reprint author), Univ Tubingen, Univ Hosp, Inst Expt & Clin Pharmacol & Toxicol, Wilhelmstr 56, D-72074 Tubingen, Germany.
EM tilman.gocht@uni-tuebingen.de
OI Thomas, Russell/0000-0002-2340-0301; Gocht, Tilma/0000-0002-2491-2050
FU European Community's Seventh Framework Programme (FP7) (project acronym
"COACH") [267044]; Cosmetics Europe; Open Access Publishing Fund of
Tubingen University
FX This research work has received funding from the European Community's
Seventh Framework Programme (FP7/2007-2013) under grant agreement no
267044 (project acronym "COACH"), and has received financing from
Cosmetics Europe. We acknowledge support by the Open Access Publishing
Fund of Tubingen University.
NR 57
TC 8
Z9 8
U1 2
U2 12
PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
PI HEILDEBERG
PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY
SN 1868-596X
EI 1868-8551
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2015
VL 32
IS 1
BP 9
EP 24
PG 16
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CA5QM
UT WOS:000348962900003
PM 25372315
ER
PT J
AU Leet, JK
Sassman, S
Amberg, JJ
Olmstead, AW
Lee, LS
Ankley, GT
Sepulveda, MS
AF Leet, Jessica K.
Sassman, Stephen
Amberg, Jon J.
Olmstead, Allen W.
Lee, Linda S.
Ankley, Gerald T.
Sepulveda, Maria S.
TI Environmental hormones and their impacts on sex differentiation in
fathead minnows
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Estrogens; Androgens; Atrazine; Animal feeding operations; Pimephales
promelas
ID ANIMAL FEEDING OPERATIONS; EARLY-LIFE-STAGES; PIMEPHALES-PROMELAS;
REPRODUCTIVE ENDOCRINOLOGY; RELEVANT CONCENTRATIONS; ESTROGENIC
CHEMICALS; STEROIDAL ESTROGENS; GENE-EXPRESSION; RAINBOW-TROUT; FISH
AB Runoff from lands fertilized with animal manure from concentrated animal feeding operations (CAFOs) is a source of hormones to surface water. In this study we tested the hypothesis that larval fathead minnows exposed to sex steroids singly or in a "typical" CAFO mixture during sex differentiation would respond with changes in the expression of a set of target genes, leading to gonadal abnormalities later in life. In the first experiment, a static daily-renewal system was used to expose larvae during the period of 10-20 days post-hatch (dph) to either 5 ng/L 17 beta-trenbolone (17 beta-TRB) or 5 ng/L 17 alpha-ethinylestradiol (EE2). In a second experiment, fish were exposed from 0 to 45 dph in a flow-through system to a CAFO mixture composed of steroids and degradates (2-16 ng/L), atrazine and degradates (15-250 ng/L), and nitrate (3-11 mg/L). In the single hormone experiment, expression of genes involved in steroidogenesis (cyp19a, cyp17, and star) was decreased in females. In contrast, no differences in gene expression were observed in fish exposed to the CAFO mixture. However, the majority (84%) of treated males had testes containing an ovarian cavity, indicative of feminization, compared to 0% in the control males. Overall, our results show that: (1) changes in gene expression after single hormone exposures are sex-specific, with females more responsive than males; and (2) phenotypic alterations in testicular development can be elicited by a simulated "CAFO" mixture when fathead minnows are exposed during the first 45 days of development. More research is needed to further discern the complex response of fish to steroid mixtures, especially those associated with runoff from land-applied CAFO waste. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Leet, Jessica K.; Sepulveda, Maria S.] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA.
[Sassman, Stephen; Lee, Linda S.] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA.
[Amberg, Jon J.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA.
[Olmstead, Allen W.] Bayer Crop Sci, Environm Toxicol & Risk Assessment, Res Triangle Pk, NC 27709 USA.
[Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Sepulveda, MS (reprint author), 195 Marsteller St, W Lafayette, IN 47907 USA.
EM jleet@mailbox.sc.edu; sassman@purdue.edu; Islee@purdue.edu;
jamberg@usgs.gov; allen.olmstead@bayer.com; ankley.gerald@epa.gov;
mssepulv@purdue.edu
RI Sepulveda, Maria/P-3598-2014
FU USEPA STAR [RD833417]; assistantship from the Department of Forestry and
Natural Resources, Purdue University
FX Funding was provided by USEPA STAR (RD833417). The lead author (JKL) was
supported by an assistantship from the Department of Forestry and
Natural Resources, Purdue University. We thank Bob Rode for his help in
various aspects of these studies.
NR 34
TC 7
Z9 7
U1 10
U2 53
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
EI 1879-1514
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD JAN
PY 2015
VL 158
BP 98
EP 107
DI 10.1016/j.aquatox.2014.10.022
PG 10
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA CA4PZ
UT WOS:000348888400011
PM 25671225
ER
PT J
AU Aluru, N
Karchner, SI
Franks, DG
Nacci, D
Champlin, D
Hahn, ME
AF Aluru, Neelakanteswar
Karchner, Sibel I.
Franks, Diana G.
Nacci, Diane
Champlin, Denise
Hahn, Mark E.
TI Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in
Atlantic killifish (Fundulus heteroclitus)
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Non-model organisms; Gene knock-outs; Mummichog; Adaptation; Zinc finger
nucleases; CRISPR-Cas9
ID ZINC-FINGER NUCLEASES; TAL EFFECTOR NUCLEASES; XENOPUS-TROPICALIS;
IN-VIVO; ENVIRONMENTAL CONTAMINANTS; CIONA-INTESTINALIS; EFFICIENT;
GENOME; DISRUPTION; ZEBRAFISH
AB Understanding molecular mechanisms of toxicity is facilitated by experimental manipulations, such as disruption of function by gene targeting, that are especially challenging in non-standard model species with limited genomic resources. While loss-of-function approaches have included gene knock-down using morpholino-modified oligonucleotides and random mutagenesis using mutagens or retroviruses, more recent approaches include targeted mutagenesis using zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology. These latter methods provide more accessible opportunities to explore gene function in non-traditional model species. To facilitate evaluation of toxic mechanisms for important categories of aryl hydrocarbon pollutants, whose actions are known to be receptor mediated, we used ZFN and CRISPR-Cas9 approaches to generate aryl hydrocarbon receptor 2a (AHR2a) and AHR2b gene mutations in Atlantic killifish (Fundulus heteroclitus) embryos. This killifish is a particularly valuable non-traditional model, with multiple paralogs of AHR whose functions are not well characterized. In addition, some populations of this species have evolved resistance to toxicants such as halogenated aromatic hydrocarbons. AHR-null killifish will be valuable for characterizing the role of the individual AHR paralogs in evolved resistance, as well as in normal development. We first used five-finger ZFNs targeting exons 1 and 3 of AHR2a. Subsequently, CRISPR-Cas9 guide RNAs were designed to target regions in exon 2 and 3 of AHR2a and AHR2b. We successfully induced frameshift mutations in AHR2a exon 3 with ZFN and CRISPR-Cas9 guide RNAs, with mutation frequencies of 10% and 16%, respectively. In AHR2b, mutations were induced using CRISPR-Cas9 guide RNAs targeting sites in both exon 2 (17%) and exon 3 (63%). We screened AHR2b exon 2 CRISPR-Cas9-injected embryos for off-target effects in AHR paralogs. No mutations were observed in closely related AHR genes (AHR1a, AHR1b,AHR2a, AHRR) in the CRISPR-Cas9-injected embryos. Overall, our results demonstrate that targeted genome-editing methods are efficient in inducing mutations at specific loci in embryos of a non-traditional model species, without detectable off-target effects in paralogous genes. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Aluru, Neelakanteswar; Karchner, Sibel I.; Franks, Diana G.; Hahn, Mark E.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA.
[Aluru, Neelakanteswar; Karchner, Sibel I.; Franks, Diana G.; Hahn, Mark E.] Boston Univ, Sch Publ Hlth, Superfund Res Program, Boston, MA USA.
[Nacci, Diane; Champlin, Denise] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA.
RP Aluru, N (reprint author), Woods Hole Oceanog Inst, Dept Biol, Redfield Bldg,MS 32,45 Water St, Woods Hole, MA 02543 USA.
EM nalurn@whoi.edu
OI Hahn, Mark/0000-0003-4358-2082
FU National Institute of Environmental Health Sciences (NIEHS) (Superfund
Research Program at Boston University) [P42ES007381]; Andrew W. Mellon
Foundation Award for Innovative Research; National Science Foundation
[DEB-1120512, DEB-1265282, DEB-1120013, DEB-1120263, DEB-1120333,
DEB-1120398]
FX This work was supported by National Institute of Environmental Health
Sciences (NIEHS) grant P42ES007381 (Superfund Research Program at Boston
University) and by an Andrew W. Mellon Foundation Award for Innovative
Research to MEH. Design of guide RNAs and primers was aided by reference
to a preliminary draft of the F. heteroclitus genome sequence, which was
supported by funding from the National Science Foundation (collaborative
research grants DEB-1120512, DEB-1265282, DEB-1120013, DEB-1120263,
DEB-1120333, DEB-1120398). We also acknowledge the help provided by Ms.
Kathryn Crawford in fish collection and embryo rearing.
NR 93
TC 7
Z9 7
U1 1
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
EI 1879-1514
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD JAN
PY 2015
VL 158
BP 192
EP 201
DI 10.1016/j.aquatox.2014.11.016
PG 10
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA CA4PZ
UT WOS:000348888400021
PM 25481785
ER
PT J
AU Kwok, RHF
Baker, KR
Napelenok, SL
Tonnesen, GS
AF Kwok, R. H. F.
Baker, K. R.
Napelenok, S. L.
Tonnesen, G. S.
TI Photochemical grid model implementation and application of VOC, NOx, and
O-3 source apportionment
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID VOLATILE ORGANIC-COMPOUNDS; RADICAL PROPAGATION EFFICIENCY; SURFACE
OZONE CONCENTRATIONS; AIR-QUALITY MODELS; UNITED-STATES; SOURCE
IDENTIFICATION; EMISSION INVENTORY; NITROGEN-OXIDES; NORTH-AMERICA;
SENSITIVITY
AB For the purposes of developing optimal emissions control strategies, efficient approaches are needed to identify the major sources or groups of sources that contribute to elevated ozone (O-3) concentrations. Source-based apportionment techniques implemented in photochemical grid models track sources through the physical and chemical processes important to the formation and transport of air pollutants. Photochemical model source apportionment has been used to track source impacts of specific sources, groups of sources (sectors), sources in specific geographic areas, and stratospheric and lateral boundary inflow on O-3. The implementation and application of a source apportionment technique for O-3 and its precursors, nitrogen oxides (NOx) and volatile organic compounds (VOCs), for the Community Multiscale Air Quality (CMAQ) model are described here. The Integrated Source Apportionment Method (ISAM) O-3 approach is a hybrid of source apportionment and source sensitivity in that O-3 production is attributed to precursor sources based on O-3 formation regime (e.g., for a NOx-sensitive regime, O-3 is apportioned to participating NOx emissions). This implementation is illustrated by tracking multiple emissions source sectors and lateral boundary inflow. NOx, VOC, and O-3 attribution to tracked sectors in the application are consistent with spatial and temporal patterns of precursor emissions. The O-3 ISAM implementation is further evaluated through comparisons of apportioned ambient concentrations and deposition amounts with those derived from brute force zero-out scenarios, with correlation coefficients ranging between 0.58 and 0.99 depending on specific combination of target species and tracked precursor emissions. Low correlation coefficients occur for chemical regimes that have strong nonlinearity in O-3 sensitivity, which demonstrates different functionalities between source apportionment and zero-out approaches, where appropriate use depends on whether source attribution or source sensitivity is desired.
C1 [Kwok, R. H. F.; Baker, K. R.; Napelenok, S. L.] US EPA, Res Triangle Pk, NC 27711 USA.
[Tonnesen, G. S.] US EPA, Denver, CO 80202 USA.
RP Napelenok, SL (reprint author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM napelenok.sergey@epa.gov
NR 67
TC 10
Z9 10
U1 9
U2 53
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 1
BP 99
EP 114
DI 10.5194/gmd-8-99-2015
PG 16
WC Geosciences, Multidisciplinary
SC Geology
GA CA5WK
UT WOS:000348978400007
ER
PT J
AU Zhao, B
Wang, SX
Xing, J
Fu, K
Fu, JS
Jang, C
Zhu, Y
Dong, XY
Gao, Y
Wu, WJ
Wang, JD
Hao, JM
AF Zhao, B.
Wang, S. X.
Xing, J.
Fu, K.
Fu, J. S.
Jang, C.
Zhu, Y.
Dong, X. Y.
Gao, Y.
Wu, W. J.
Wang, J. D.
Hao, J. M.
TI Assessing the nonlinear response of fine particles to precursor
emissions: development and application of an extended response surface
modeling technique v1.0
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID ADJOINT SENSITIVITY-ANALYSIS; YANGTZE-RIVER DELTA; AIR-QUALITY MODELS;
PHOTOCHEMICAL MODELS; INORGANIC AEROSOLS; CONTROL STRATEGIES; OZONE
CONTROL; HIGH-ORDER; CHINA; POLLUTION
AB An innovative extended response surface modeling technique (ERSM v1.0) is developed to characterize the nonlinear response of fine particles (PM2.5) to large and simultaneous changes of multiple precursor emissions from multiple regions and sectors. The ERSM technique is developed based on the conventional response surface modeling (RSM) technique; it first quantifies the relationship between PM2.5 concentrations and the emissions of gaseous precursors from each single region using the conventional RSM technique, and then assesses the effects of inter-regional transport of PM2.5 and its gaseous precursors on PM2.5 concentrations in the target region. We apply this novel technique with a widely used regional chemical transport model (CTM) over the Yangtze River delta (YRD) region of China, and evaluate the response of PM2.5 and its inorganic components to the emissions of 36 pollutant-region-sector combinations. The predicted PM2.5 concentrations agree well with independent CTM simulations; the correlation coefficients are larger than 0.98 and 0.99, and the mean normalized errors (MNEs) are less than 1 and 2% for January and August, respectively. It is also demonstrated that the ERSM technique could reproduce fairly well the response of PM2.5 to continuous changes of precursor emission levels between zero and 150 %. Employing this new technique, we identify the major sources contributing to PM2.5 and its inorganic components in the YRD region. The nonlinearity in the response of PM2.5 to emission changes is characterized and the underlying chemical processes are illustrated.
C1 [Zhao, B.; Wang, S. X.; Fu, K.; Wu, W. J.; Wang, J. D.; Hao, J. M.] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Wang, S. X.; Hao, J. M.] State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China.
[Xing, J.; Jang, C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Fu, J. S.; Dong, X. Y.; Gao, Y.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Zhu, Y.] S China Univ Technol, Sch Environm Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China.
[Gao, Y.] Pacific NW Natl Lab, Atmospher Sci & Global Change Div, Richland, WA 99352 USA.
RP Wang, SX (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
EM shxwang@tsinghua.edu.cn
RI xing, jia/O-1784-2014; wang, shuxiao/H-5990-2011
OI wang, shuxiao/0000-0001-9727-1963
FU National Natural Science Foundation of China [21221004]; Strategic
Priority Research Program of the Chinese Academy of Sciences
[XBD05020300]; MEP's Special Funds for Research on Public Welfares
[201409002, 201309009]; Collaborative Innovation Center for Regional
Environmental Quality of Tsinghua University
FX This work was sponsored by National Natural Science Foundation of China
(21221004), Strategic Priority Research Program of the Chinese Academy
of Sciences (XBD05020300), and MEP's Special Funds for Research on
Public Welfares (201409002, 201309009). The authors also appreciate the
support from Collaborative Innovation Center for Regional Environmental
Quality of Tsinghua University. Our work was completed on the Explorer
100 cluster system of Tsinghua National Laboratory for Information
Science and Technology.
NR 38
TC 8
Z9 8
U1 2
U2 28
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
EI 1991-9603
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2015
VL 8
IS 1
BP 115
EP 128
DI 10.5194/gmd-8-115-2015
PG 14
WC Geosciences, Multidisciplinary
SC Geology
GA CA5WK
UT WOS:000348978400008
ER
PT J
AU Fischer, BM
Voynow, JA
Ghio, AJ
AF Fischer, Bernard M.
Voynow, Judith A.
Ghio, Andrew J.
TI COPD: balancing oxidants and antioxidants
SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
LA English
DT Review
DE cigarette smoking; mucins; gene regulation; Chinese herbs; acupuncture;
dietary antioxidants
ID OBSTRUCTIVE PULMONARY-DISEASE; RANDOMIZED CONTROLLED-TRIAL; NUTRITION
EXAMINATION SURVEY; INCREASED OXIDATIVE STRESS; EXHALED BREATH
CONDENSATE; SMALL-AIRWAY OBSTRUCTION; GENOME-WIDE ASSOCIATION; GOBLET
CELL METAPLASIA; RETINOL EFFICACY TRIAL; 3RD NATIONAL-HEALTH
AB Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses in the world. The disease encompasses emphysema, chronic bronchitis, and small airway obstruction and can be caused by environmental exposures, primarily cigarette smoking. Since only a small subset of smokers develop COPD, it is believed that host factors interact with the environment to increase the propensity to develop disease. The major pathogenic factors causing disease include infection and inflammation, protease and antiprotease imbalance, and oxidative stress overwhelming antioxidant defenses. In this review, we will discuss the major environmental and host sources for oxidative stress; discuss how oxidative stress regulates chronic bronchitis; review the latest information on genetic predisposition to COPD, specifically focusing on oxidant/antioxidant imbalance; and review future antioxidant therapeutic options for COPD. The complexity of COPD will necessitate a multi-target therapeutic approach. It is likely that antioxidant supplementation and dietary antioxidants will have a place in these future combination therapies.
C1 [Fischer, Bernard M.] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA.
[Voynow, Judith A.] Virginia Commonwealth Univ, Childrens Hosp Richmond, Dept Pediat, Richmond, VA USA.
[Ghio, Andrew J.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Fischer, BM (reprint author), Duke Univ, Med Ctr, Dept Pediat, Box 103201, Durham, NC 27710 USA.
EM bernie.fischer@duke.edu
NR 169
TC 6
Z9 6
U1 2
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2005
J9 INT J CHRONIC OBSTR
JI Int. J. Chronic Obstr. Pulm. Dis.
PY 2015
VL 10
DI 10.2147/COPD.S42414
PG 16
WC Respiratory System
SC Respiratory System
GA CA2JN
UT WOS:000348734800001
ER
PT J
AU Zhu, Y
Lao, YW
Jang, C
Lin, CJ
Xing, J
Wang, SX
Fu, JS
Deng, S
Xie, JP
Long, SC
AF Zhu, Yun
Lao, Yanwen
Jang, Carey
Lin, Chen-Jen
Xing, Jia
Wang, Shuxiao
Fu, Joshua S.
Deng, Shuang
Xie, Junping
Long, Shicheng
TI Development and case study of a science-based software platform to
support policy making on air quality
SO JOURNAL OF ENVIRONMENTAL SCIENCES
LA English
DT Article
DE Air quality; Policy making; Response surface modeling; Emission control
scenarios; Data visualization
ID CHINA; SYSTEM; MODEL; IMPACT
AB This article describes the development and implementations of a novel software platform that supports real-time, science-based policy making on air quality through a user-friendly interface. The software, RSM-VAT, uses a response surface modeling (RSM) methodology and serves as a visualization and analysis tool (VAT) for three-dimensional air quality data obtained by atmospheric models. The software features a number of powerful and intuitive data visualization functions for illustrating the complex nonlinear relationship between emission reductions and air quality benefits. The case study of contiguous U.S. demonstrates that the enhanced RSM-VAT is capable of reproducing the air quality model results with Normalized Mean Bias <2% and assisting in air quality policy making in near real time. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
C1 [Zhu, Yun; Lin, Chen-Jen] S China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou 510006, Guangdong, Peoples R China.
[Zhu, Yun; Xing, Jia; Wang, Shuxiao] Tsinghua Univ, Sch Environm, State Environm Protect Key Lab Sources & Control, Beijing 100084, Peoples R China.
[Lao, Yanwen; Xie, Junping; Long, Shicheng] S China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangzhou 510006, Guangdong, Peoples R China.
[Jang, Carey] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Lin, Chen-Jen] Lamar Univ, Dept Civil Engn, Beaumont, TX 77710 USA.
[Fu, Joshua S.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Deng, Shuang] Chinese Res Inst Environm Sci, Beijing 100012, Peoples R China.
RP Zhu, Y (reprint author), S China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou 510006, Guangdong, Peoples R China.
EM zhuyun@scut.edu.cn
RI xing, jia/O-1784-2014; wang, shuxiao/H-5990-2011; Lin,
Che-Jen/K-1808-2013
OI wang, shuxiao/0000-0001-9727-1963; Lin, Che-Jen/0000-0001-5990-3093
FU U.S. Environmental Protection Agency [GS-10F-0205T]; Guangdong
Provincial Key Laboratory of Atmospheric Environment and Pollution
Control [h2xjD612004III]; State Environmental Protection Key Laboratory
of Sources and Control of Air Pollution Complex [SCAPC201308]; project
of Atmospheric Haze Collaboration Control Technology Design from Chinese
Academy of Sciences [XDB05030400]
FX Financial and data support for this work is provided by the U.S.
Environmental Protection Agency (No. GS-10F-0205T). This work is also
partly supported by the funding of Guangdong Provincial Key Laboratory
of Atmospheric Environment and Pollution Control (No. h2xjD612004III),
the funding of State Environmental Protection Key Laboratory of Sources
and Control of Air Pollution Complex (No. SCAPC201308), and the project
of Atmospheric Haze Collaboration Control Technology Design (No.
XDB05030400) from Chinese Academy of Sciences.
NR 21
TC 3
Z9 4
U1 3
U2 11
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1001-0742
EI 1878-7320
J9 J ENVIRON SCI-CHINA
JI J. Environ. Sci.
PD JAN 1
PY 2015
VL 27
BP 97
EP 107
DI 10.1016/j.jes.2014.08.016
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CA3SC
UT WOS:000348825400012
PM 25597667
ER
PT J
AU Tatum-Gibbs, KR
Mckee, JM
Higuchi, M
Bushnell, PJ
AF Tatum-Gibbs, K. R.
Mckee, J. M.
Higuchi, M.
Bushnell, P. J.
TI Effects of toluene, acrolein and vinyl chloride on motor activity of
Drosophila melanogaster
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Article
DE Toxicity screening; Volatile organic compounds; Fruit fly; Sex
difference; Narcosis
ID VOLATILE ORGANIC-COMPOUNDS; GENOME-WIDE ASSOCIATION; GENETIC REFERENCE
PANEL; ODOR-GUIDED BEHAVIOR; LOCOMOTOR-ACTIVITY; NATURAL VARIATION;
OLFACTORY BEHAVIOR; ARCHITECTURE; COMMUNICATION; INHALATION
AB The data generated by current high-throughput assays for chemical toxicity require information to link effects at molecular targets to adverse outcomes in whole animals. In addition, more efficient methods for testing volatile chemicals are needed. Here we begin to address these issues by determining the utility of measuring behavioral responses of Drosophila melanogaster to airborne volatile organic compounds (VOCs) as a potential model system for discovering adverse outcome pathways and as a method to test for toxicity. In these experiments, we measured motor activity in male and female flies to determine concentration-effect functions for three VOCs that differ in their mode of action: toluene, a narcotic; acrolein, an irritant; and vinyl chloride, a hepatocarcinogen. These experiments were conducted in Flyland, an outbred population of flies derived from 40 lines of the Drosophila Genetics Reference Panel (DGRP) (Mackay et al., 2012), in preparation for subsequent experiments with individual lines of the DGRP. Systematic, concentration-related changes in activity were observed with toluene, but not with acrolein; high concentrations of vinyl chloride reduced activity by a small amount. Despite higher activity levels in males than in females under control conditions, the sexes were equally sensitive to toluene. Transient increases in activity at the onset and offset of exposure to toluene and vinyl chloride suggested that the flies detected changes in air quality at concentrations that did not persistently suppress activity. The effects and potency of toluene are consistent with those observed in rodents. The lack of clear concentration-related changes in response to acrolein and vinyl chloride shows limitations of this method is for screening toxicity attributed to VOCs. This abstract does not reflect U.S. EPA policy. Published by Elsevier Inc.
C1 [Tatum-Gibbs, K. R.] Oak Ridge Inst Sci Educ, Oak Ridge, TN USA.
[Mckee, J. M.; Higuchi, M.; Bushnell, P. J.] US EPA, Natl Hlth & Environm Effects Res Lab, RTP, Res Triangle Pk, NC 27711 USA.
RP Bushnell, PJ (reprint author), US EPA, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab, MD B105-04, Res Triangle Pk, NC 27711 USA.
EM Bushnell.philip@epa.gov
NR 49
TC 1
Z9 2
U1 1
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
EI 1872-9738
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JAN-FEB
PY 2015
VL 47
BP 114
EP 124
DI 10.1016/j.ntt.2014.11.008
PG 11
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA CA5NL
UT WOS:000348955000013
PM 25445728
ER
PT J
AU Morgan, M
Jones, P
Sobus, J
AF Morgan, Marsha
Jones, Paul
Sobus, Jon
TI Short-Term Variability and Predictors of Urinary Pentachlorophenol
Levels in Ohio Preschool Children
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE biomarkers; urine; children; determinants; phenol; home; daycare center
ID PERSISTENT ORGANIC POLLUTANTS; INDOOR AIR; DAY-CARE; AGGREGATE
EXPOSURES; PESTICIDES; DUST; ENVIRONMENT; POPULATION; RESIDUES; DIAZINON
AB Pentachlorophenol (PCP) is a persistent and ubiquitous environmental contaminant. No published data exist on the temporal variability or important predictors of urinary PCP concentrations in young children. In this further analysis of study data, we have examined the associations between selected sociodemographic or lifestyle factors and urinary PCP concentrations in 115 preschool children over a 48-h period and assessed the 48-hour variability of urinary PCP levels in a subset of 15 children. Monitoring was performed at 115 homes and 16 daycares in Ohio (USA) in 2001. Questionnaires/diaries and spot urine samples were collected from each child. The median urinary PCP level was 0.8 ng/mL (range < 0.2-23.8 ng/mL). The intraclass correlation coefficient for urinary PCP was 0.42, which indicates fairly low reliability for a single sample over a 48-h period. In a multiple regression model, age of home and ln(creatinine levels) were significant predictors and sampling season, time spent outside, and pet ownership were marginally significant predictors of ln(urinary PCP levels), collectively explaining 29% of the variability of PCP in urine. To adequately assess short-term exposures of children to PCP, several spot urine measurements are likely needed as well as information regarding residence age, seasonality, time spent outdoors, and pet ownership.
C1 [Morgan, Marsha; Jones, Paul; Sobus, Jon] US EPA, Res Triangle Pk, NC 27711 USA.
RP Morgan, M (reprint author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM morgan.marsha@epa.gov; jones.paul-a@epa.gov; sobus.jon@epa.gov
FU United States Environmental Protection Agency through Office of Research
and Development [68-D-99-011]
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here
under Contract #68-D-99-011 to Battelle. It has been subjected to Agency
review and approved for publication.
NR 36
TC 1
Z9 1
U1 1
U2 10
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2015
VL 12
IS 1
BP 800
EP 815
DI 10.3390/ijerph120100800
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AZ7MP
UT WOS:000348403300047
PM 25594782
ER
PT J
AU Sickles, JE
Shadwick, DS
AF Sickles, J. E., II
Shadwick, D. S.
TI Air quality and atmospheric deposition in the eastern US: 20 years of
change
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID DRY DEPOSITION; UNITED-STATES; TRENDS-NETWORK; PARTICULATE SULFATE;
NITROGEN DEPOSITION; MULTILAYER MODEL; AEROSOL NITRATE; SULFUR;
EMISSIONS; FORESTS
AB Data collected in the eastern US between 1990 and 2009 at 34 paired dry and wet monitoring sites are examined. A goal is to evaluate the air quality impacts occurring between 1990 and 2009 that are associated with concurrent legislatively mandated changes in emissions. Four 5-year periods, 1990-1994 (P1), 1995-1999 (P2), 2000-2004 (P3), and 2005-2009 (P4) are considered, with a primary focus on P1-to-P4 changes. Results suggest that legislatively mandated air pollution mitigation strategies have been successful in improving air quality and reducing atmospheric deposition in the eastern US.
Respective P1-to-P4 reductions of estimated sulfur dioxide (SO2) and nitrogen oxides (NOx) emissions in the eastern US are 50 and 42 %. Corresponding behavior of the following metrics associated with these emissions reductions is examined: monitored atmospheric concentrations of SO2, aerosol sulfate (SO4), and oxidized sulfur (S); dry, wet, and total deposition of S; monitored atmospheric concentrations of nitric acid (HNO3), aerosol nitrate (NO3), and their sum, oxidized nitrogen (OxN); dry, wet, and total deposition of OxN; monitored atmospheric concentration of aerosol ammonium (NH4); dry, wet, and total deposition of NH4; summed monitored atmospheric concentration of oxidized and reduced nitrogen (N); dry, wet, and total deposition of N; wet deposition of hydrogen ion (H+); monitored atmospheric concentration of ozone (O-3); dry deposition of O-3; and the summed monitored atmospheric concentration of aerosol NO3, SO4, and NH4 (Clean Air Status and Trends Network particulate matter - CASTNET PM). Other metrics (e.g., ratios of dry to total deposition) are also considered.
Selected period-to-period changes of air quality and deposition metrics at site, regional, and seasonal scales are discussed. As an example, despite P1-to-P3 reductions in estimated emissions of both SO2 and NOx, aerosol NO3 concentration increased in the east, with widespread wintertime numerical increases in both aerosol NO3 concentration and CASTNET PM. However, a reversal of this behavior is associated with continuing P3-to-P4 reductions of SO2 and NOx emissions. Thus, additional P3-to-P4 reductions of these emissions, especially NOx, appear to have made progress in altering the chemical regime of the wintertime eastern US atmosphere so that future emissions reductions and their resulting reductions in aerosol concentrations may no longer be accompanied by sub-linear changes (or actual increases) in CASTNET PM.
C1 [Sickles, J. E., II] US EPA, Landscape Characterizat Branch, Div Environm Sci, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Shadwick, D. S.] Comp Sci Corp, Durham, NC 27713 USA.
RP Sickles, JE (reprint author), US EPA, Landscape Characterizat Branch, Div Environm Sci, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM sickles.joseph@epa.gov
FU US EPA through its Office of Research and Development [GS-35F-4381G,
BPA0775, 1521, TDD 2-5]
FX The US EPA, through its Office of Research and Development, funded and
partially performed the research described here under contract
GS-35F-4381G, BPA0775, Task Order 1521, TDD 2-5, to CSC Corporation.
This manuscript has been subjected to Agency review and approved for
publication.
NR 41
TC 7
Z9 9
U1 5
U2 61
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2015
VL 15
IS 1
BP 173
EP 197
DI 10.5194/acp-15-173-2015
PG 25
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AZ0TQ
UT WOS:000347958200011
ER
PT J
AU Bal-Price, A
Crofton, KM
Sachana, M
Shafer, TJ
Behl, M
Forsby, A
Hargreaves, A
Landesmann, B
Lein, PJ
Louisse, J
Monnet-Tschudi, F
Paini, A
Rolaki, A
Schrattenholz, A
Sunol, C
van Thriel, C
Whelan, M
Fritsche, E
AF Bal-Price, Anna
Crofton, Kevin M.
Sachana, Magdalini
Shafer, Timothy J.
Behl, Mamta
Forsby, Anna
Hargreaves, Alan
Landesmann, Brigitte
Lein, Pamela J.
Louisse, Jochem
Monnet-Tschudi, Florianne
Paini, Alicia
Rolaki, Alexandra
Schrattenholz, Andre
Sunol, Cristina
van Thriel, Christoph
Whelan, Maurice
Fritsche, Ellen
TI Putative adverse outcome pathways relevant to neurotoxicity
SO CRITICAL REVIEWS IN TOXICOLOGY
LA English
DT Review
DE adverse outcome pathway; in vitro testing; key events; molecular
initiating event; pathways of neurotoxicity; predictive toxicology
ID POSTOPERATIVE COGNITIVE DYSFUNCTION; ESTROGEN-RECEPTOR BINDING;
DEVELOPMENTAL NEUROTOXICITY; RISK-ASSESSMENT; NERVOUS-SYSTEM;
ALTERNATIVE METHODS; MAGNETIC-RESONANCE; MATURE HIPPOCAMPUS; PROGENITOR
CELLS; ANIMAL-MODELS
AB The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs). The AOP starts with an molecular initiating event (MIE) in which a chemical interacts with a biological target(s), followed by a sequential series of KEs, which are cellular, anatomical, and/or functional changes in biological processes, that ultimately result in an AO manifest in individual organisms and populations. It has been developed as a tool for a knowledge-based safety assessment that relies on understanding mechanisms of toxicity, rather than simply observing its adverse outcome. A large number of cellular and molecular processes are known to be crucial to proper development and function of the central (CNS) and peripheral nervous systems (PNS). However, there are relatively few examples of well-documented pathways that include causally linked MIEs and KEs that result in adverse outcomes in the CNS or PNS. As a first step in applying the AOP framework to adverse health outcomes associated with exposure to exogenous neurotoxic substances, the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) organized a workshop (March 2013, Ispra, Italy) to identify potential AOPs relevant to neurotoxic and developmental neurotoxic outcomes. Although the AOPs outlined during the workshop are not fully described, they could serve as a basis for further, more detailed AOP development and evaluation that could be useful to support human health risk assessment in a variety of ways.
C1 [Bal-Price, Anna; Sachana, Magdalini; Landesmann, Brigitte; Louisse, Jochem; Paini, Alicia; Rolaki, Alexandra; Whelan, Maurice] European Commiss Joint Res Ctr, Inst Hlth & Consumer Protect, Ispra, Italy.
[Crofton, Kevin M.; Shafer, Timothy J.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA.
[Behl, Mamta] Natl Inst Environm Hlth Sci, Div Natl Toxicol Program, Res Triangle Pk, NC USA.
[Forsby, Anna] Stockholm Univ, Arrhenius Labs NaturalSci, Dept Neurochem, S-10691 Stockholm, Sweden.
[Forsby, Anna] Swedish Toxicol Sci Res Ctr, Swetox, Sodertalje, Sweden.
[Hargreaves, Alan] Nottingham Trent Univ, Nottingham, England.
[Lein, Pamela J.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
[Monnet-Tschudi, Florianne] Univ Lausanne, Dept Physiol, Lausanne, Switzerland.
[Monnet-Tschudi, Florianne] Univ Lausanne, SCAHT, Lausanne, Switzerland.
[Schrattenholz, Andre] ProteoSys AG, Mainz, Germany.
[Sunol, Cristina] CIBERESP, IDIBAPS, IIBB CSIC, Inst Invest Biomed Barcelona, Barcelona, Spain.
[van Thriel, Christoph] IfADo Leibniz Res Ctr Working Environm & Human Fa, Dortmund, Germany.
[Fritsche, Ellen] IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany.
RP Bal-Price, A (reprint author), Commiss European Communities, Joint Res Ctr, Inst Hlth & Consumer Protect, Syst Toxicol Unit,EURL ECVAM, TP 580,Via Fermi 1, I-21026 Ispra, VA, Italy.
EM anna.price@jrc.ec.europa
RI Crofton, Kevin/J-4798-2015;
OI Crofton, Kevin/0000-0003-1749-9971; Forsby, Anna/0000-0001-6298-201X;
Cristina, Sunol/0000-0001-9367-8483; Hargreaves,
Alan/0000-0001-9754-5477
FU European Commission
FX The employment affiliation of the authors is shown on the cover page.
The authors have sole responsibility for the writing and content of this
paper. The contributing authors were participants of the workshop
organized by the EURL ECVAM. The external workshop participants were
invited on the basis of a survey performed by EURL ECVAM neurotoxicity
experts of the latest literature to identify those with specific
expertise in the relevant research fields. The workshop organization was
financially supported by the European Commission, including the cost of
travelling and per diem of all invited external experts. The strategy
for preparing the report, the literature selected for review, the
conclusions drawn and the recommendations made are exclusively the
collective scientific output of the workshop participants and do not
necessarily represent the views of the participants' employers.
NR 66
TC 13
Z9 13
U1 5
U2 34
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1040-8444
EI 1547-6898
J9 CRIT REV TOXICOL
JI Crit. Rev. Toxicol.
PD JAN
PY 2015
VL 45
IS 1
BP 83
EP 91
DI 10.3109/10408444.2014.981331
PG 9
WC Toxicology
SC Toxicology
GA AZ4NN
UT WOS:000348199100005
PM 25605028
ER
PT J
AU Nixon, SW
Oczkowski, AJ
Pilson, MEQ
Fields, L
Oviatt, CA
Hunt, CW
AF Nixon, Scott W.
Oczkowski, Autumn J.
Pilson, Michael E. Q.
Fields, Lindsey
Oviatt, Candace A.
Hunt, Christopher W.
TI On the Response of pH to Inorganic Nutrient Enrichment in Well-Mixed
Coastal Marine Waters
SO ESTUARIES AND COASTS
LA English
DT Article
DE Coastal acidification; pH; Nutrient enrichment; Eutrophication;
Mesocosms; Narragansett Bay
ID ORGANIC-CARBON BALANCE; OCEAN ACIDIFICATION; NARRAGANSETT BAY; ECOSYSTEM
METABOLISM; EUTROPHICATION; PHYTOPLANKTON; CO2; SALINITY; GROWTH;
ESTUARINE
AB Recent concerns about declining pH in the surface ocean in response to anthropogenic increases of carbon dioxide (CO2) in the atmosphere have raised the question of how this declining baseline of oceanic pH might interact with the much larger diel and seasonal variations of pH in coastal marine ecosystems. Nutrient enrichment, which can amplify both production and respiration, has the potential to reduce or exacerbate the impacts of ocean acidification in coastal waters. Here, we present results from a multi-year experiment in which replicate phytoplankton-based mesocosms with a 5-m deep well-mixed water column (salinity = 27-31) and intact benthic community were exposed to a gradient in daily inorganic nitrogen (N), phosphorous (P), and silica (Si) addition. We show that the response of water column pH to nutrient enrichment was the greatest during the autotrophic winter-spring period, and there was no significant decline in pH across treatments during the heterotrophic summer-fall period. We believe that the differences in response lie in the seasonal cycles of production and respiration, where spring production peaks are large and discrete, and respiration is more temperature-driven but occurs diffusely throughout the year. The observed basification associated with enhanced nutrient inputs may have consequences for phytoplankton community structure, some species of submersed aquatic vegetation, cycling of Si, and perhaps other ecological processes.
C1 [Nixon, Scott W.; Pilson, Michael E. Q.; Fields, Lindsey; Oviatt, Candace A.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
[Oczkowski, Autumn J.] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Hunt, Christopher W.] Univ New Hampshire, Ocean Proc Anal Lab, Durham, NH 03824 USA.
RP Oczkowski, AJ (reprint author), US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM oczkowski.autumn@epa.gov
OI Hunt, Christopher/0000-0001-8061-4560
FU Environmental Protection Agency Centers Program [807795-02, 810265-01];
NSF [12010, OCE851447]; US Environmental Protection Agency
FX The observations described in this manuscript were discovered by S.
Nixon. He began writing the text of the manuscript and, after his
untimely death, his coauthors completed the manuscript and published it
posthumously in his honor. We would like to thank the scientists and
technicians who worked on the MERL mesocosm experiments, and upon whose
careful measurements, this manuscript is based. We are grateful to Alana
Hanson for some statistical support. The MERL nutrient addition
experiment was supported by the Environmental Protection Agency Centers
Program, Cooperative Agreements 807795-02 and 810265-01. Support for
this work was also partially provided by the NSF Awards 12010 and
OCE851447. This is ORD tracking number ORD-003895 of the Atlantic
Ecology Division, National Health and Environmental Effects Research
Laboratory, Office of Research and Development, US Environmental
Protection Agency. Although the research described in this article has
been funded in part by the US Environmental Protection Agency, it has
not been subjected to Agency review. Therefore, it does not necessarily
reflect the views of the Agency.
NR 63
TC 3
Z9 3
U1 3
U2 40
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
IS 1
BP 232
EP 241
DI 10.1007/s12237-014-9805-6
PG 10
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AY6MM
UT WOS:000347680300019
ER
PT J
AU Russell, M
Greening, H
AF Russell, Marc
Greening, Holly
TI Estimating Benefits in a Recovering Estuary: Tampa Bay, Florida
SO ESTUARIES AND COASTS
LA English
DT Article
DE Ecosystem goods; Tampa Bay; Estuarine valuation; Habitat restoration;
Water quality
ID MANGROVE SEDIMENTS; INORGANIC NITROGEN; ECOSYSTEM SERVICES;
WATER-QUALITY; DENITRIFICATION; SEAGRASS; EUTROPHICATION; FLUXES;
CARBON; REDUCTIONS
AB Restoration and preservation of riparian forests and coastal marshes provides nutrient removal and other biochemical and physical functions which may preclude, reduce, or delay the need for additional water treatment, while also protecting human health. We examined the ecosystem goods and related potential cost savings for the Tampa Bay community from seagrass expansion (more than 3,100 ha since 1990), coastal marsh, and mangrove restoration/recovery (more than 600 ha since 1990), and habitat that has been maintained or preserved. Habitats in and around Tampa Bay provide nutrient reductions equivalent to just over US$22 million per year in avoided wastewater treatment plant costs. Future accrual of value associated with maintaining the ecosystem good of usable clean water could rapidly increase to as high as similar to US$ 3 billion per year, when one takes into account the additional costs of water treatment and storm water diversion infrastructure that is likely as the region's population continues to grow. There is additional value accrual close to a quarter million dollars per year based on avoided social costs to the global community due to greenhouse gases sequestered by bay habitats. Most human beneficiaries associated with the maintenance of usable clean water in Tampa Bay are part of the surrounding regional community. The large current and future cost savings for the community surrounding Tampa Bay and additional benefits for the global community speak to the value of maintaining a healthy bay through past and continued restoration and preservation efforts.
C1 [Russell, Marc] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32563 USA.
[Greening, Holly] Tampa Bay Estuary Program, Petersburg, FL 33701 USA.
RP Russell, M (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32563 USA.
EM Russell.Marc@epamail.epa.gov
NR 52
TC 1
Z9 1
U1 9
U2 69
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
SU 1
BP S9
EP S18
DI 10.1007/s12237-013-9662-8
PG 10
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AZ0TE
UT WOS:000347956700002
ER
PT J
AU Teisl, MF
McCoy, S
Marrinan, S
Noblet, CL
Johnson, T
Wibberly, M
Roper, R
Klein, S
AF Teisl, Mario F.
McCoy, Shannon
Marrinan, Sarah
Noblet, Caroline L.
Johnson, Teresa
Wibberly, Megan
Roper, Robert
Klein, Sharon
TI Will Offshore Energy Face "Fair Winds and Following Seas"?:
Understanding the Factors Influencing Offshore Wind Acceptance
SO ESTUARIES AND COASTS
LA English
DT Article
DE Offshore wind power; Public acceptance
ID PUBLIC ACCEPTANCE; POWER PROJECTS; ATTITUDES; TURBINES; FARMS
AB Most offshore energy studies have focused on measuring or explaining people's perceptions of, and reactions to, specific installations. However, there are two different types of acceptance: one surrounds the siting of projects while the other surrounds a more general acceptance of offshore energy. Understanding what drives this second type of acceptance is important as governments have implemented new financial incentives and policies to support renewable energy development; however, citizens and government officials may be increasingly opposed to some of these support mechanisms. Our paper fills a void in the literature by using regression approaches to better understand how people's evaluations of the benefits and costs of offshore wind impact their level of general acceptance for offshore wind, while controlling for other factors (e.g., demographics). This analysis should help policy makers, and individuals attempting to educate the general public about renewable energy, to better understand the important factors influencing people's support or opposition to offshore wind energy initiatives.
C1 [Teisl, Mario F.; Noblet, Caroline L.; Klein, Sharon] Univ Maine, Sch Econ, Orono, ME 04469 USA.
[McCoy, Shannon] Univ Maine, Dept Psychol, Orono, ME 04469 USA.
[Marrinan, Sarah] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
[Johnson, Teresa] Univ Maine, Sch Marine Sci, Orono, ME 04469 USA.
[Wibberly, Megan] Isl Inst, Rockland, ME 04841 USA.
[Roper, Robert] Univ Maine Augusta, Business Adm, Augusta, ME 04330 USA.
RP Teisl, MF (reprint author), Univ Maine, Sch Econ, Orono, ME 04469 USA.
EM teisl@maine.edu
OI teisl, mario/0000-0002-2021-9208
FU Maine Sustainability Solutions Initiative; National Science Foundation
[EPS-0904155]; Maine Agriculture and Forest Experiment Station
FX Funding was provided by the Maine Sustainability Solutions Initiative,
the National Science Foundation Grant EPS-0904155 to Maine EPSCoR at the
University of Maine, and the Maine Agriculture and Forest Experiment
Station.
NR 41
TC 2
Z9 2
U1 2
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
SU 1
BP S279
EP S286
DI 10.1007/s12237-014-9777-6
PG 8
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AZ0TE
UT WOS:000347956700023
ER
PT J
AU Yoskowitz, D
Russell, M
AF Yoskowitz, David
Russell, Marc
TI Human Dimensions of Our Estuaries and Coasts
SO ESTUARIES AND COASTS
LA English
DT Editorial Material
ID ECOLOGICAL RESILIENCE
C1 [Yoskowitz, David] Texas A&M Univ Corpus Christi, Harte Res Inst, Corpus Christi, TX 78412 USA.
[Russell, Marc] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Yoskowitz, D (reprint author), Texas A&M Univ Corpus Christi, Harte Res Inst, 6300 Ocean Dr, Corpus Christi, TX 78412 USA.
EM david.yoskowitz@tamucc.edu
NR 20
TC 3
Z9 3
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD JAN
PY 2015
VL 38
SU 1
BP S1
EP S8
DI 10.1007/s12237-014-9926-y
PG 8
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AZ0TE
UT WOS:000347956700001
ER
PT J
AU Briskin, J
AF Briskin, Jeanne
TI Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking
Water Resources
SO GROUNDWATER
LA English
DT Editorial Material
C1 US EPA, Off Water, Engn & Anal Div, Washington, DC 20460 USA.
RP Briskin, J (reprint author), US EPA, Off Water, Engn & Anal Div, 1200 Penn Ave,NW, Washington, DC 20460 USA.
EM Briskin.Jeanne@epa.gov
NR 0
TC 1
Z9 1
U1 1
U2 25
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0017-467X
EI 1745-6584
J9 GROUNDWATER
JI Groundwater
PD JAN-FEB
PY 2015
VL 53
IS 1
BP 19
EP 21
PG 3
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA AZ1EA
UT WOS:000347981800006
PM 25713827
ER
PT J
AU Brown, JS
AF Brown, James S.
TI Nitrogen dioxide exposure and airway responsiveness in individuals with
asthma
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Air pollution; airway responsiveness; asthma; nitrogen dioxide
ID EMERGENCY-DEPARTMENT VISITS; SHORT-TERM EXPOSURE; INHALED ALLERGEN;
BRONCHIAL RESPONSIVENESS; AMBIENT LEVEL; PROVOKED BRONCHOCONSTRICTION;
PULMONARY-FUNCTION; DEEP INSPIRATION; CASE-CROSSOVER; METHACHOLINE
AB Controlled human exposure studies evaluating the effect of inhaled nitrogen dioxide (NO2) on the inherent responsiveness of the airways to challenge by broncho-constricting agents have had mixed results. In general, existing meta-analyses show statistically significant effects of NO2 on the airway responsiveness of individuals with asthma. However, no meta-analysis has provided a comprehensive assessment of the clinical relevance of changes in airway responsiveness, the potential for methodological biases in the original papers, and the distribution of responses. This paper provides analyses showing that a statistically significant fraction (i.e. 70% of individuals with asthma exposed to NO2 at rest) experience increases in airway responsiveness following 30-min exposures to NO2 in the range of 200 to 300 ppb and following 60-min exposures to 100 ppb. The distribution of changes in airway responsiveness is log-normally distributed with a median change of 0.75 (provocative dose following NO2 divided by provocative dose following filtered air exposure) and geometric standard deviation of 1.88. About a quarter of the exposed individuals experience a clinically relevant reduction in their provocative dose due to NO2 relative to air exposure. The fraction experiencing an increase in responsiveness was statistically significant and robust to exclusion of individual studies. Results showed minimal change in airway responsiveness for individuals exposed to NO2 during exercise.
C1 US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Brown, JS (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, B243-01, Res Triangle Pk, NC 27711 USA.
EM Brown.James@epa.gov
NR 66
TC 2
Z9 2
U1 3
U2 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JAN
PY 2015
VL 27
IS 1
BP 1
EP 14
DI 10.3109/08958378.2014.979960
PG 14
WC Toxicology
SC Toxicology
GA AZ3QN
UT WOS:000348141900001
PM 25431034
ER
PT J
AU Perez, CM
Hazari, MS
Ledbetter, AD
Haykal-Coates, N
Carll, AP
Cascio, WE
Winsett, DW
Costa, DL
Farraj, AK
AF Perez, Christina M.
Hazari, Mehdi S.
Ledbetter, Allen D.
Haykal-Coates, Najwa
Carll, Alex P.
Cascio, Wayne E.
Winsett, Darrell W.
Costa, Daniel L.
Farraj, Aimen K.
TI Acrolein inhalation alters arterial blood gases and triggers carotid
body-mediated cardiovascular responses in hypertensive rats
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Acrolein; blood pressure; carotid body; pO(2); spontaneously
hypertensive rat
ID OBSTRUCTIVE PULMONARY-DISEASE; HEART-RATE-VARIABILITY;
INFANT-DEATH-SYNDROME; AIR-POLLUTION; OXYGEN-SATURATION; EXPOSURE;
SMOKE; HYPOXIA; STRESS; BODIES
AB Context: Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen and carbon dioxide levels, and elicits downstream changes in autonomic control and cardiac function.
Objective: We hypothesized that exposure to acrolein, an unsaturated aldehyde and mucosal irritant found in cigarette smoke and diesel exhaust, would activate the carotid body chemoreceptor response and lead to secondary cardiovascular responses in rats.
Materials and methods: Spontaneously hypertensive (SH) rats were exposed once for 3 h to 3 ppm acrolein gas or filtered air in whole body plethysmograph chambers. To determine if the carotid body mediated acrolein-induced cardiovascular responses, rats were pretreated with an inhibitor of cystathionine gamma-lyase (CSE), an enzyme essential for carotid body signal transduction.
Results: Acrolein exposure induced several cardiovascular effects. Systolic, diastolic and mean arterial blood pressure increased during exposure, while cardiac contractility decreased 1 day after exposure. The cardiovascular effects were associated with decreases in pO(2), breathing frequency and expiratory time, and increases in sympathetic tone during exposure followed by parasympathetic dominance after exposure. The CSE inhibitor prevented the cardiovascular effects of acrolein exposure.
Discussion and conclusion: Pretreatment with the CSE inhibitor prevented the cardiovascular effects of acrolein, suggesting that the cardiovascular responses with acrolein may be mediated by carotid body-triggered changes in autonomic tone. (This abstract does not reflect EPA policy.)
C1 [Perez, Christina M.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Hazari, Mehdi S.; Ledbetter, Allen D.; Cascio, Wayne E.; Winsett, Darrell W.; Farraj, Aimen K.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA.
[Haykal-Coates, Najwa] US EPA, Biostatt & Bioinformat Res Core Unit, NHEERL, Res Triangle Pk, NC 27711 USA.
[Carll, Alex P.] Univ N Carolina, Chapel Hill, NC USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Perez, CM (reprint author), US EPA, Environm Publ Hlth Div, B143-01, Res Triangle Pk, NC 27711 USA.
EM clamb@email.unc.edu
OI Carll, Alex/0000-0003-1832-3070
FU EPA/UNC Toxicology Training Agreement [CR-83515201-0]
FX This work was supported by the EPA/UNC Toxicology Training Agreement
[CR-83515201-0 to C.M.P. and A.P.C.]. The funding sources had no
involvement in this work, and all authors report no declaration of
interest.
NR 37
TC 3
Z9 3
U1 0
U2 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JAN
PY 2015
VL 27
IS 1
BP 54
EP 63
DI 10.3109/08958378.2014.984881
PG 10
WC Toxicology
SC Toxicology
GA AZ3QN
UT WOS:000348141900004
PM 25600140
ER
PT J
AU Ge, Y
Bruno, M
Wallace, K
Leavitt, S
Andrews, D
Spassova, MA
Xi, MY
Roy, A
Haykal-Coates, N
Lefew, W
Swank, A
Winnik, WM
Chen, C
Woodard, J
Farraj, A
Teichman, KY
Ross, JA
AF Ge, Yue
Bruno, Maribel
Wallace, Kathleen
Leavitt, Sharon
Andrews, Debora
Spassova, Maria A.
Xi, Mingyu
Roy, Anindya
Haykal-Coates, Najwa
Lefew, William
Swank, Adam
Winnik, Witold M.
Chen, Chao
Woodard, Jonne
Farraj, Aimen
Teichman, Kevin Y.
Ross, Jeffrey A.
TI Systematic Proteomic Approach to Characterize the Impacts of Chemical
Interactions on Protein and Cytotoxicity Responses to Metal Mixture
Exposures
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE chemical interactions; dose response; mixture toxicity; chemical
mixtures; risk assessment; proteomics; cytotoxicity; metals; systems
biology
ID TOXICITY; CELLS; NICKEL
AB Chemical interactions have posed a big challenge in toxicity characterization and human health risk assessment of environmental mixtures. To characterize the impacts of chemical interactions on protein and cytotoxicity responses to environmental mixtures, we established a systems biology approach integrating proteomics, bioinformatics, statistics, and computational toxicology to measure expression or phosphorylation levels of 21 critical toxicity pathway regulators and 445 downstream proteins in human BEAS-2B cells treated with 4 concentrations of nickel, 2 concentrations each of cadmium and chromium, as well as 12 defined binary and 8 defined ternary mixtures of these metals in vitro. Multivariate statistical analysis and mathematical modeling of the metal-mediated proteomic response patterns showed a high correlation between changes in protein expression or phosphorylation and cellular toxic responses to both individual metals and metal mixtures. Of the identified correlated proteins, only a small set of proteins including HIF-1 alpha is likely to be responsible for selective cytotoxic responses to different metals and metals mixtures. Furthermore, support vector machine learning was utilized to computationally predict protein responses to uncharacterized metal mixtures using experimentally generated protein response profiles corresponding to known metal mixtures. This study provides a novel proteomic approach for characterization and prediction of toxicities of metal and other chemical mixtures.
C1 [Ge, Yue; Bruno, Maribel; Wallace, Kathleen; Leavitt, Sharon; Andrews, Debora; Haykal-Coates, Najwa; Lefew, William; Swank, Adam; Winnik, Witold M.; Woodard, Jonne; Farraj, Aimen; Ross, Jeffrey A.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA.
[Spassova, Maria A.; Chen, Chao] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Teichman, Kevin Y.] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Xi, Mingyu; Roy, Anindya] Univ Maryland, Dept Stat, College Pk, MD 20742 USA.
RP Ge, Y (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM ge.yue@epa.gov
OI Ross, Jeffrey/0000-0002-7002-4548
FU Pathfinder Innovation Project (PIP) from Office of Research and
Development ORD), U.S. Environmental Protection Agency
FX This research was supported by the Pathfinder Innovation Project (PIP)
from Office of Research and Development ORD), U.S. Environmental
Protection Agency. We acknowledge all of the support provided by Peter
Preuss and the innovation team, ORD. We also thank Drs. Andrew
Kligerman, Julian Preston, and Mehdi Hazari for their very helpful
comments on this manuscript and Alan Tennant for his assistance on the
apoptosis imaging. The information in this document has been funded
wholly by the U.S. Environmental Protection Agency. It has been
subjected to review by the National Health and Environmental Effects
Research Laboratory and approved for publication. Approval does not
signify that the contents reflect the views of the Agency nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 20
TC 4
Z9 4
U1 0
U2 12
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD JAN
PY 2015
VL 14
IS 1
BP 183
EP 192
PG 10
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA AY3UA
UT WOS:000347506600016
PM 25285964
ER
PT J
AU Kapoor, V
Pitkanen, T
Ryu, H
Elk, M
Wendell, D
Domingo, JWS
AF Kapoor, Vikram
Pitkaenen, Tarja
Ryu, Hodon
Elk, Michael
Wendell, David
Domingo, Jorge W. Santo
TI Distribution of Human-Specific Bacteroidales and Fecal Indicator
Bacteria in an Urban Watershed Impacted by Sewage Pollution, Determined
Using RNA-and DNA-Based Quantitative PCR Assays
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID 16S RIBOSOMAL-RNA; MICROBIAL SOURCE TRACKING; ESCHERICHIA-COLI;
CONTAMINATION; IDENTIFICATION; POPULATIONS; COMMUNITY; QPCR;
ENVIRONMENTS; ENTEROCOCCUS
AB The identification of fecal pollution sources is commonly carried out using DNA-based methods. However, there is evidence that DNA can be associated with dead cells or present as "naked DNA" in the environment. Furthermore, it has been shown that rRNA-targeted reverse transcription-quantitative PCR (RT-qPCR) assays can be more sensitive than rRNA gene-based qPCR assays since metabolically active cells usually contain higher numbers of ribosomes than quiescent cells. To this end, we compared the detection frequency of host-specific markers and fecal bacteria using RNA-based RT-qPCR and DNA-based qPCR methods for water samples collected in sites impacted by combined sewer overflows. As a group, fecal bacteria were more frequently detected in most sites using RNA-based methods. Specifically, 8, 87, and 85% of the samples positive for general enterococci, Enterococcus faecalis, and Enterococcus faecium markers, respectively, were detected using RT-qPCR, but not with the qPCR assay counterpart. On average, two human-specific Bacteroidales markers were not detected when using DNA in 12% of the samples, while they were positive for all samples when using RNA (cDNA) as the template. Moreover, signal intensity was up to three orders of magnitude higher in RT-qPCR assays than in qPCR assays. The human-specific Bacteroidales markers exhibited moderate correlation with conventional fecal indicators using RT-qPCR results, suggesting the persistence of nonhuman sources of fecal pollution or the presence of false-positive signals. In general, the results from this study suggest that RNA-based assays can increase the detection sensitivity of fecal bacteria in urban watersheds impacted with human fecal sources.
C1 [Kapoor, Vikram; Ryu, Hodon; Elk, Michael] Pegasus Tech Serv Inc, Cincinnati, OH USA.
[Kapoor, Vikram; Wendell, David] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Cincinnati, OH USA.
[Pitkaenen, Tarja] Natl Inst Hlth & Welf, Water & Hlth Unit, Kuopio, Finland.
[Pitkaenen, Tarja; Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Domingo, JWS (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM wendeldw@uc.edu; santodomingo.jorge@epa.gov
RI Pitkanen, Tarja/D-1657-2014
OI Pitkanen, Tarja/0000-0002-7591-9148
FU University Research Council fellowship at University of Cincinnati; Osk.
Huttunen Foundation; National Research Council; Metropolitan Sewer
District of Greater Cincinnati (Cincinnati, OH); U.S. Environmental
Protection Agency, through its Office of Research and Development;
Finnish Cultural Foundation; University of Eastern Finland
FX V.K. was funded by a University Research Council fellowship at
University of Cincinnati. T.P. was supported by research grants from the
Osk. Huttunen Foundation, the Finnish Cultural Foundation, and the
University of Eastern Finland. H.R. was the recipient of a National
Research Council fellowship. This research was in part funded by
Metropolitan Sewer District of Greater Cincinnati (Cincinnati, OH). The
U.S. Environmental Protection Agency, through its Office of Research and
Development, provided funds and collaborated in the research described
here.
NR 57
TC 8
Z9 8
U1 2
U2 25
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JAN
PY 2015
VL 81
IS 1
BP 91
EP 99
DI 10.1128/AEM.02446-14
PG 9
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AY1TZ
UT WOS:000347376200011
PM 25326295
ER
PT J
AU Chu, DA
Ferrare, R
Szykman, J
Lewis, J
Scarino, A
Hains, J
Burton, S
Chen, G
Tsai, T
Hostetler, C
Hair, J
Holben, B
Crawford, J
AF Chu, D. Allen
Ferrare, Richard
Szykman, James
Lewis, Jasper
Scarino, Amy
Hains, Jennifer
Burton, Sharon
Chen, Gao
Tsai, Tzuchin
Hostetler, Chris
Hair, Johnathan
Holben, Brent
Crawford, James
TI Regional characteristics of the relationship between columnar AOD and
surface PM2.5: Application of lidar aerosol extinction profiles over
Baltimore-Washington Corridor during DISCOVER-AQ
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE DISCOVER-AQ; Baltimore-Washington Corridor; HSRL; MPLNET; DRAGON;
AERONET; MODIS; ADD; Aerosol mixing layer; Haze layer height; PM2.5
ID BOUNDARY-LAYER DEPTH; OPTICAL DEPTH; AIR-QUALITY; PARTICULATE; MODIS;
POLLUTION; URBAN; LAND; VALIDATION; THICKNESS
AB The first field campaign of DISCOVER-AQ (Deriving Information on Surface conditions from COlumn and VERtically resolved observations relevant to Air Quality) took place in July 2011 over Baltimore-Washington Corridor (BWC). A suite of airborne remote sensing and in-situ sensors was deployed along with ground networks for mapping vertical and horizontal distribution of aerosols. Previous researches were based on a single lidar station because of the lack of regional coverage. This study uses the unique airborne HSRL (High Spectral Resolution Lidar) data to baseline PM2.5 (particulate matter of aerodynamic diameter less than 2.5 mu m) estimates and applies to regional air quality with satellite AOD (Aerosol Optical Depth) retrievals over BWC (similar to 6500 km(2)). The linear approximation takes into account aerosols aloft above AML (Aerosol Mixing Layer) by normalizing AOD with haze layer height (i.e., AOD/HLH). The estimated PM2.5 mass concentrations by HSRL AOD/FILH are shown within 2 RMSE (Root Mean Square Error similar to 9.6 mu g/m(3)) with correlation similar to 0.88 with the observed over BWC. Similar statistics are shown when applying HLH data from a single location over the distance of 100 km. In other words, a single lidar is feasible to cover the range of 100 km with expected uncertainties. The employment of MPLNET-AERONET (MicroPulse Lidar NETwork - AErosol RObotic NETwork) measurements at NASA GSFC produces similar statistics of PM2.5 estimates as those derived by HSRL. The synergy of active and passive remote sensing aerosol measurements provides the foundation for satellite application of air quality on a daily basis. For the optimal range of 10 km, the MODIS-estimated PM2.5 values are found satisfactory at 27 (out of 36) sunphotometer locations with mean RMSE of 1.6-3.3 mu g/m(3) relative to PM2.5 estimated by sunphotometers. The remaining 6 of 8 marginal sites are found in the coastal zone, for which associated large RMSE values similar to 4.5-7.8 mu g/m(3) are most likely due to overestimated AOD because of water-contaminated pixels. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Chu, D. Allen; Lewis, Jasper] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA.
[Chu, D. Allen; Lewis, Jasper; Holben, Brent] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Ferrare, Richard; Szykman, James; Scarino, Amy; Burton, Sharon; Chen, Gao; Hostetler, Chris; Hair, Johnathan; Crawford, James] NASA, Langley Res Ctr, Sci Directorate, Hampton, VA 23665 USA.
[Szykman, James] US EPA, Res Triangle Pk, NC 27711 USA.
[Hains, Jennifer] Maryland Dept Environm, Baltimore, MD 21224 USA.
[Tsai, Tzuchin] Univ Maryland, College Pk, MD 20742 USA.
[Tsai, Tzuchin] Natl Taiwan Univ, Taipei 10764, Taiwan.
RP Chu, DA (reprint author), NASA, Goddard Space Flight Ctr, JCET UMBC, Greenbelt, MD 20771 USA.
EM allen.chu@nasa.gov
RI Xiongfei, Zhao/G-7690-2015
FU NASA DISCOVER-AQ [NNX10AR41G]; NASA Air Now [NNX11A176G]
FX We would like to thank HSRL and LARGE teams for acquiring and processing
measurements during DISCOVER-AQ field campaign in July 2011 as well as
AERONET/DRAGON and MPLNET teams for processing sunphotometer and
micro-pulse lidar data. Thanks especially go to Maryland Department of
Environment for providing hourly PM2.5 and meteorological
measurements. We would also like to thank MODIS aerosol team and MODAP
for processing MODIS AOD retrievals. The development of the methodology
and the analysis of multiple-sensor data products are performed under
the NASA grants DISCOVER-AQ (NNX10AR41G) and Air Now (NNX11A176G). The
views, opinions, and findings contained in this article are those of the
authors and should not be construed as official U.S. Environmental
Protection Agency, National Aeronautics and Space Administration, or
U.S. Government position, policy, or decision
NR 39
TC 10
Z9 10
U1 6
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JAN
PY 2015
VL 101
BP 338
EP 349
DI 10.1016/j.atmosenv.2014.11.034
PG 12
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AZ1SB
UT WOS:000348017000034
ER
PT J
AU Zhao, HB
Peddada, SD
Cui, XP
AF Zhao, Haibing
Peddada, Shyamal D.
Cui, Xinping
TI Mixed directional false discovery rate control in multiple pairwise
comparisons using weighted p-values
SO BIOMETRICAL JOURNAL
LA English
DT Article; Proceedings Paper
CT 8th International Conference on Multiple Comparison Procedures (MCP2013)
CY JUL 08-11, 2013
CL Univ Southampton, Southampton, UNITED KINGDOM
HO Univ Southampton
DE Benjamini Hochberg procedure; Microarray; Mixed directional false
discovery rate; Multiple pairwise comparison; Weighted p-value
ID LIVER-CANCER; ACETAMINOPHEN; PROPORTION; LANDSCAPE; TUMORS; NULL
AB In many applications, researchers are interested in making q pairwise comparisons among k test groups on the basis of m outcome variables. Often, m is very large. For example, such situations arise in gene expression microarray studies involving several experimental groups. Researchers are often not only interested in identifying differentially expressed genes between a given pair of experimental groups, but are also interested in making directional inferences such as whether a gene is up-or downregulated in one treatment group relative to another. In such situations, in addition to the usual errors such as false positive (Type I error) and false negative (Type II error), one may commit directional error (Type III error). For example, in a dose response microarray study, a gene may be declared to be upregulated in the high dose group compared to the low dose group when it is not. In this paper, we introduce a mixed directional false discovery rate (mdFDR) controlling procedure using weighted p-values to select positives in different directions. The weights are defined as the inverse of two times the proportion of either positive or negative discoveries. The proposed procedure has been proved mathematically to control the mdFDR at level a and to have a larger power (which is defined as the expected proportion of nontrue null hypotheses) than the GSP10 procedure proposed by Guo et al. (2010). Simulation studies and real data analysis are also conducted to show the outperformance of the proposed procedure than the GSP10 procedure.
C1 [Zhao, Haibing] Shanghai Univ Finance & Econ, Sch Stat & Management, Shanghai 200433, Peoples R China.
[Peddada, Shyamal D.] Natl Inst Environm Hlth Sci, Biostat Branch, Res Triangle Pk, NC 27709 USA.
[Cui, Xinping] Univ Calif Riverside, Dept Stat, Ctr Plant Cell Biol, Riverside, CA 92521 USA.
RP Cui, XP (reprint author), Univ Calif Riverside, Dept Stat, Ctr Plant Cell Biol, Riverside, CA 92521 USA.
EM xinping.cui@ucr.edu
FU National Natural Science Foundation of China (NSFC) [11101255];
University of California AES-CE RSAP grant [A01869]; NIH, National
Institute of Environmental Health Sciences [Z01 ES101744-04]
FX The research of H.Z. was supported by a grant from the National Natural
Science Foundation of China (NSFC) [No. 11101255]. The research of XC
was supported, in part, by University of California AES-CE RSAP grant
[A01869]. The research of SDP was supported, in part, by the Intramural
Research Program of the NIH, National Institute of Environmental Health
Sciences [Z01 ES101744-04].
NR 30
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0323-3847
EI 1521-4036
J9 BIOMETRICAL J
JI Biom. J.
PD JAN
PY 2015
VL 57
IS 1
SI SI
BP 144
EP 158
DI 10.1002/bimj.201300242
PG 15
WC Mathematical & Computational Biology; Statistics & Probability
SC Mathematical & Computational Biology; Mathematics
GA AY4GO
UT WOS:000347536500011
PM 25410394
ER
PT J
AU Shumchenia, EJ
Pelletier, MC
Cicchetti, G
Davies, S
Pesch, CE
Deacutis, CF
Pryor, M
AF Shumchenia, Emily J.
Pelletier, Marguerite C.
Cicchetti, Giancarlo
Davies, Susan
Pesch, Carol E.
Deacutis, Christopher F.
Pryor, Margherita
TI A Biological Condition Gradient Model for Historical Assessment of
Estuarine Habitat Structure
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Biological condition gradient; Biological assessment; Biological
indicators; Habitat; Resource-based management; Stressors
ID BASE-LINE SYNDROME; NARRAGANSETT BAY; RHODE-ISLAND; MARINE ECOSYSTEMS;
COASTAL; MANAGEMENT; FRAMEWORK; IMPACTS; TEMPERATURE; NUTRIENTS
AB Coastal ecosystems are affected by ever-increasing natural and human pressures. Because the physical, chemical, and biological characteristics unique to estuarine ecosystems control the ways that biological resources respond to ecosystem stressors, we present a flexible and adaptable biological assessment method for estuaries. The biological condition gradient (BCG) is a scientific framework of biological response to increasing anthropogenic stress that is comprehensive and ecosystem based and evaluates environmental conditions and the status of ecosystem services in order to identify, communicate, and prioritize management action. Using existing data, we constructed the first estuarine BCG framework that examines changes in habitat structure through time. Working in a New England (U.S.) estuary with a long history of human influence, we developed an approach to define a reference level, which we described as a "minimally disturbed" range of conditions for the ecosystem, anchored by observations before 1850 AD. Like many estuaries in the U.S., the relative importance of environmental stressors changed over time, but even qualitative descriptions of the biological indicators' status provided useful information for defining condition levels. This BCG demonstrated that stressors rarely acted alone and that declines in one biological indicator influenced the declines of others. By documenting the biological responses to cumulative stressors, the BCG inherently suggests an ecosystem-based approach to management. Additionally, the BCG process initiates thinking over long time scales and can be used to inspire scientists, managers, and the public toward environmental action.
C1 [Shumchenia, Emily J.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett Bay, RI 02882 USA.
[Pelletier, Marguerite C.; Cicchetti, Giancarlo; Pesch, Carol E.] US EPA, Atlantic Ecol Div, Off Res & Dev, Narragansett Bay, RI 02882 USA.
[Davies, Susan] Maine Dept Environm Protect, Augusta, ME 04333 USA.
[Deacutis, Christopher F.] Rhode Isl Dept Environm Management, Div Fish & Wildlife, Jamestown, RI 02835 USA.
[Pryor, Margherita] US EPA, Off Water, Boston, MA 02109 USA.
RP Shumchenia, EJ (reprint author), E&C Enviroscape LLC, Ashaway, RI 02804 USA.
EM emily.shumchenia@gmail.com
FU U.S. EPA Office of Water and Region 1; U.S. EPA
FX This work was funded by the U.S. EPA Office of Water and Region 1.
Although this research was funded by the U.S. EPA, the views expressed
here do not necessarily represent those of the Agency. The authors wish
to thank the participants of both BCG workshops held in Narragansett, RI
and the numerous groups and individuals who have contributed data
regarding the ecology of Narragansett Bay. The ideas and efforts of
these individuals created a foundation for the estuarine BCG framework
and case study. We would also like to thank P. Bradley, R. McKinney, S.
Ayvasian, John Paul, and two anonymous reviewers for thoughtful review
of this manuscript. This is EPA contribution # ORD-003233.
NR 66
TC 1
Z9 1
U1 3
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD JAN
PY 2015
VL 55
IS 1
BP 143
EP 158
DI 10.1007/s00267-014-0401-0
PG 16
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AY7BG
UT WOS:000347715600012
PM 25387456
ER
PT J
AU Rhodes, ER
Boczek, LA
Ware, MW
McKay, M
Hoelle, JM
Schoen, M
Villegas, EN
AF Rhodes, Eric R.
Boczek, Laura A.
Ware, Michael W.
McKay, Mary
Hoelle, Jill M.
Schoen, Mary
Villegas, Eric N.
TI Determining Pathogen and Indicator Levels in Class B Municipal Organic
Residuals Used for Land Application
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID MICROBIAL RISK-ASSESSMENT; CRYPTOSPORIDIUM-PARVUM OOCYSTS; WASTE-WATER
TREATMENT; DRINKING-WATER; SEWAGE-SLUDGE; IMMUNOMAGNETIC SEPARATION;
TREATMENT PLANTS; BIOSOLIDS; GIARDIA; CYSTS
AB Biosolids are nutrient-rich organic residuals that are currently used to amend soils for food production. Treatment requirements to inactivate pathogens for production of Class A biosolids are energy intensive. One less energy intensive alternative is to treat biosolids to Class B standards, but it could result in higher pathogen loads. Quantitative microbial risk assessments models have been developed on land application of Class B biosolids but contain many uncertainties because of limited data on specific pathogen densities and the use of fecal indicator organisms as accurate surrogates of pathogen loads. To address this gap, a 12-mo study of the levels and relationships between Cryptosporidium, Giardia, and human adenovirus (HAdV) with fecal coliform, somatic, and F-RNA coliphage levels in Class B biosolids from nine wastewater treatment plants throughout the United States was conducted. Results revealed that fecal coliform, somatic, and F-RNA coliphage densities were consistent throughout the year. More important, results revealed that HAdV ((x) over bar = 2.5 x 10(3) genome copies dry g(-1)) and Giardia ((x) over bar = 4.14 x 103 cysts dry g(-1)) were in all biosolids samples regardless of treatment processes, location, or season. Cryptosporidium oocysts were also detected (38% positive; range: 0-1.9 x 103 oocysts dry g(-1)), albeit sporadically. Positive correlations among three fecal indicator organisms and HAdV, but not protozoa, were also observed. Overall, this study reveals that high concentrations of enteric pathogens (e.g., Cryptosporidium, Giardia, and HAdV) are present in biosolids throughout the United States. Microbial densities found can further assist management and policymakers in establishing more accurate risk assessment models associated with land application of Class B biosolids.
C1 [Rhodes, Eric R.; Ware, Michael W.; McKay, Mary; Schoen, Mary; Villegas, Eric N.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Boczek, Laura A.; Hoelle, Jill M.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Villegas, EN (reprint author), US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM villegas.eric@epa.gov
RI Villegas, Eric/A-7373-2015
OI Villegas, Eric/0000-0002-8059-8588
FU U.S. Environmental Protection Agency through its Office of Research and
Development
FX We would like to thank all the POTWs that participated in the study and
Chandler Stevens for technical assistance. We also acknowledge Ron
Hermann and Carolyn Acheson for their scientific discussions. We would
like to thank Asja Korajkic and Mark Meckes for critical review of the
manuscript. The U.S. Environmental Protection Agency through its Office
of Research and Development funded and managed the research described
here. It has been subjected to the Agency's administrative review and
approved for publication. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. Author
contributions: ERR, LAB, MS, and ENV conceived and designed the
experiments; ERR, LAB, MWW, MM, JMH, ENV performed the experiments
and/or collected field samples; ERR, LAB, MWW, MS, and ENV, analyzed the
data; ERR, LAB, MWW, MS, and ENV wrote the paper.
NR 36
TC 3
Z9 3
U1 2
U2 18
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
EI 1537-2537
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD JAN-FEB
PY 2015
VL 44
IS 1
BP 265
EP 274
DI 10.2134/jeq2014.04.0142
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AY8YH
UT WOS:000347836100029
PM 25602342
ER
PT J
AU Rosenbaum, PF
Crawford, JA
Hunt, A
Vesper, SJ
Abraham, JL
AF Rosenbaum, P. F.
Crawford, J. A.
Hunt, A.
Vesper, S. J.
Abraham, J. L.
TI Environmental Relative Moldiness Index and Associations with Home
Characteristics and Infant Wheeze
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
LA English
DT Article
DE ERMI; infants; mold; wheeze
ID QUANTITATIVE PCR ANALYSIS; ASTHMATIC-CHILDREN; 1ST YEAR; COHORT; FUNGI;
MOLD; PREDICTOR; SYRACUSE; EXPOSURE; RISK
AB Possible relationships between mold contamination, as described by the Environmental Relative Moldiness Index (ERMI), home characteristics, and the development of wheeze in the first year of life were evaluated among a cohort of urban infants (n = 103) in Syracuse, New York. Pregnant women with a history of asthma were recruited in 2001-2002 for the "Assessment of Urban Dwellings for Indoor Toxics" (AUDIT) study. When the infants were approximately 3 months of age, a home inspection was carried out and indoor environmental samples collected, including vacuumed house dust. ERMI levels in the Syracuse cohort homes were higher than the U.S. average, with an overall mean of 11.4. ERMI levels were significantly higher in homes with visible water problems (p = 0.023) and visiblemold (p = 0.023). ERMI levels in apartments were significantly lower than the values measured in houses (p = 0.0003). While infants experiencing wheeze (38%) tended to live in homes with higher ERMI values than those without wheeze (ERMI values of 12.3 and 10.9, respectively), the differences did not reach statistical significance. A subset analysis limited to infants with living room samples who remained in the same home during the study (n = 25) was suggestive of an association between higher ERMI values and wheeze (p = 0.10). In summary, the ERMI is a standardized metric which allows for comparison of moldiness levels in homes across studies and regions in the United States. ERMI levels in Syracuse homes were skewed to the high end of the national scale. Higher ERMI levels were indicators of water problems, mold, and type of housing.
C1 [Rosenbaum, P. F.] SUNY Upstate Med Univ, Dept Publ Hlth & Prevent Med, Syracuse, NY 13210 USA.
[Crawford, J. A.] SUNY Coll Environm Sci & Forestry, Grad Program Environm Sci, Syracuse, NY 13210 USA.
[Hunt, A.] Univ Texas Arlington, Dept Earth & Environm Sci, Arlington, TX 76019 USA.
[Vesper, S. J.] US EPA, Cincinnati, OH 45268 USA.
[Abraham, J. L.] SUNY Upstate Med Univ, Dept Pathol, Syracuse, NY 13210 USA.
RP Rosenbaum, PF (reprint author), SUNY Upstate Med Univ, Dept Publ Hlth & Prevent Med, 750 East Adams St, Syracuse, NY 13210 USA.
EM rosenbap@upstate.edu
FU Environmental Protection Agency [GR828605-01-0]; NYSTAR; Department of
Pathology, SUNY Upstate Medical University, Syracuse, New York
FX Funding for the original AUDIT study was from the Environmental
Protection Agency, Grant # GR828605-01-0. Other sources of funding were
NYSTAR and the Department of Pathology, SUNY Upstate Medical University,
Syracuse, New York.
NR 29
TC 2
Z9 2
U1 1
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1545-9624
EI 1545-9632
J9 J OCCUP ENVIRON HYG
JI J. Occup. Environ. Hyg.
PD JAN
PY 2015
VL 12
IS 1
BP 29
EP 36
DI 10.1080/15459624.2014.933958
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AZ1ZJ
UT WOS:000348033600004
PM 25068535
ER
PT J
AU Wahman, DG
Speitel, GE
AF Wahman, David G.
Speitel, Gerald E., Jr.
TI Hydroxylamine addition impact to Nitrosomonas europaea activity in the
presence of monochloramine
SO WATER RESEARCH
LA English
DT Article
DE Hydroxylamine; Monochloramine; Drinking water; Nitrification;
Nitrosornonas europaea
ID MONOAZIDE QUANTITATIVE PCR; LIVE/DEAD BACLIGHT METHODS; DRINKING-WATER
CONDITIONS; DISINFECTION KINETICS; CHLORAMINE; NITRIFICATION;
INACTIVATION; OXIDATION
AB In drinking water, monochloramine may promote ammonia-oxidizing bacteria (AOB) growth because of concurrent ammonia presence. AOB use (i) ammonia monooxygenase for biological ammonia oxidation to hydroxylamine and (ii) hydroxylamine oxidoreductase for biological hydroxylamine oxidation to nitrite. In addition, monochloramine and hydroxylamine abiotically react, providing AOB a potential benefit by removing the disinfectant (monochloramine) and releasing growth substrate (ammonia). Alternatively and because biological hydroxylamine oxidation supplies the electrons (reductant) required for biological ammonia oxidation, the monochloramine/hydroxylamine abiotic reaction represents a possible inactivation mechanism by consuming hydroxylamine and inhibiting reductant generation. To investigate the abiotic monochloramine and hydroxylamine reaction's impact on AOB activity, the current study used batch experiments with Nitrosomonas europaea (AOB pure culture), ammonia, monochloramine, and hydroxylamine addition. To decipher whether hydroxylamine addition benefitted N. europaea activity by (i) removing monochloramine and releasing free ammonia or (ii) providing an additional effect (possibly the aforementioned reductant source), a previously developed cometabolism model was coupled with an abiotic monochloramine and hydroxylamine model for data interpretation. N. europaea maintained ammonia oxidizing activity when hydroxylamine was added before complete ammonia oxidation cessation. The impact could not be accounted for by monochloramine removal and free ammonia release alone and was concentration dependent for both monochloramine and hydroxylamine. In addition, a preferential negative impact occurred for ammonia versus hydroxylamine oxidation. These results suggest an additional benefit of exogenous hydroxylamine addition beyond monochloramine removal and free ammonia release, possibly providing reductant generation. Published by Elsevier Ltd.
C1 [Wahman, David G.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Speitel, Gerald E., Jr.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA.
RP Wahman, DG (reprint author), US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM wahman.david@epa.gov
NR 31
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U1 2
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD JAN 1
PY 2015
VL 68
BP 719
EP 730
DI 10.1016/j.watres.2014.10.054
PG 12
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AY7RO
UT WOS:000347756900065
PM 25462776
ER
PT J
AU King, KE
Clarke, PJ
AF King, Katherine E.
Clarke, Philippa J.
TI A Disadvantaged Advantage in Walkability: Findings From Socioeconomic
and Geographical Analysis of National Built Environment Data in the
United States
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE built environment; census tracts; health disparities; sociodemographic
factors; urban form; walkability
ID PHYSICAL-ACTIVITY; AIR-POLLUTION; LAND-USE; PUBLIC-HEALTH; NEIGHBORHOOD
CHARACTERISTICS; URBAN FORM; DISPARITIES; POPULATIONS; INTERVENTIONS;
AVAILABILITY
AB Urban form-the structure of the built environment-can influence physical activity, yet little is known about how walkable design differs according to neighborhood sociodemographic composition. We studied how walkable urban form varies by neighborhood sociodemographic composition, region, and urbanicity across the United States. Using linear regression models and 2000-2001 US Census data, we investigated the relationship between 5 neighborhood census characteristics (income, education, racial/ethnic composition, age distribution, and sex) and 5 walkability indicators in almost 65,000 census tracts in 48 states and the District of Columbia. Data on the built environment were obtained from the RAND Corporation's (Santa Monica, California) Center for Population Health and Health Disparities (median block length, street segment, and node density) and the US Geological Survey's National Land Cover Database (proportion open space and proportion highly developed). Disadvantaged neighborhoods and those with more educated residents were more walkable (i.e., shorter block length, greater street node density, more developed land use, and higher density of street segments). However, tracts with a higher proportion of children and older adults were less walkable (fewer street nodes and lower density of street segments), after adjustment for region and level of urbanicity. Research and policy on the walkability-health link should give nuanced attention to the gap between persons living in walkable areas and those for whom walkability has the most to offer.
C1 [King, Katherine E.] US EPA, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA.
RP King, KE (reprint author), US EPA, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM kk183@duke.edu
FU Research Participation Program of the Environmental Protection Agency
(Office of Research and Development); Eunice Kennedy Shriver National
Institute of Child Health and Human Development [R24 HD041028]
FX This work was supported in part by an appointment to the Research
Participation Program of the Environmental Protection Agency (Office of
Research and Development), administered by the Oak Ridge Institute for
Science and Education (Oak Ridge, Tennessee) through an interagency
agreement between the US Department of Energy and the Environmental
Protection Agency.; We appreciate the use of the services and facilities
of the Population Studies Center at the University of Michigan (Ann
Arbor, Michigan), which is supported by Center Grant R24 HD041028 from
the Eunice Kennedy Shriver National Institute of Child Health and Human
Development.
NR 89
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U1 8
U2 39
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2015
VL 181
IS 1
BP 17
EP 25
DI 10.1093/aje/kwu310
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AY2JF
UT WOS:000347414700002
PM 25414159
ER
PT J
AU King, KE
AF King, Katherine E.
TI Dr. King Responds to "History of Place, Life Course, and Health
Inequalities"
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Editorial Material
C1 US EPA, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA.
RP King, KE (reprint author), US EPA, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM kk183@duke.edu
NR 2
TC 1
Z9 1
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2015
VL 181
IS 1
BP 30
EP 31
DI 10.1093/aje/kwu315
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AY2JF
UT WOS:000347414700004
PM 25414160
ER
PT J
AU Buse, HY
Lu, JR
Ashbolt, NJ
AF Buse, Helen Y.
Lu, Jingrang
Ashbolt, Nicholas J.
TI Exposure to Synthetic Gray Water Inhibits Amoeba Encystation and Alters
Expression of Legionella pneumophila Virulence Genes
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID FREE-LIVING AMEBAS; ON-SITE TREATMENT; ACANTHAMOEBA-CASTELLANII;
GREYWATER REUSE; HARTMANNELLA-VERMIFORMIS; RESISTING BACTERIA; DOMESTIC
GREYWATER; MICROBIAL QUALITY; ESCHERICHIA-COLI; SECRETION SYSTEM
AB Water conservation efforts have focused on gray water (GW) usage, especially for applications that do not require potable water quality. However, there is a need to better understand environmental pathogens and their free-living amoeba (FLA) hosts within GW, given their growth potential in stored gray water. Using synthetic gray water (sGW) we examined three strains of the waterbased pathogen Legionella pneumophila and its FLA hosts Acanthamoeba polyphaga, A. castellanii, and Vermamoeba vermiformis. Exposure to sGW for 72 h resulted in significant inhibition (P < 0.0001) of amoebal encystation versus control-treated cells, with the following percentages of cysts in sGW versus controls: A. polyphaga (0.6 versus 6%), A. castellanii (2 versus 62%), and V. vermiformis (1 versus 92%), suggesting sGW induced maintenance of the actively feeding trophozoite form. During sGW exposure, L. pneumophila culturability decreased as early as 5 h (1.3 to 2.9 log(10) CFU, P < 0.001) compared to controls (Delta 0 to 0.1 log(10) CFU) with flow cytometric analysis revealing immediate changes in membrane permeability. Furthermore, reverse transcription-quantitative PCR was performed on total RNA isolated from L. pneumophila cells at 0 to 48 h after sGW incubation, and genes associated with virulence (gacA, lirR, csrA, pla, and sidF), the type IV secretion system (lvrB and lvrE), and metabolism (ccmF and lolA) were all shown to be differentially expressed. These results suggest that conditions within GW may promote interactions between water-based pathogens and FLA hosts, through amoebal encystment inhibition and alteration of bacterial gene expression, thus warranting further exploration into FLA and L. pneumophila behavior in GW systems.
C1 [Buse, Helen Y.] Dynamac Corp, Cincinnati, OH USA.
[Lu, Jingrang; Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Buse, HY (reprint author), Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
EM buse.helen@epa.gov
NR 62
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U1 4
U2 18
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JAN
PY 2015
VL 81
IS 2
BP 630
EP 639
DI 10.1128/AEM.03394-14
PG 10
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AY1UL
UT WOS:000347377500019
PM 25381242
ER
PT J
AU Attene-Ramos, MS
Huang, RL
Michael, S
Witt, KL
Richard, A
Tice, RR
Simeonov, A
Austin, CP
Xia, MH
AF Attene-Ramos, Matias S.
Huang, Ruili
Michael, Sam
Witt, Kristine L.
Richard, Ann
Tice, Raymond R.
Simeonov, Anton
Austin, Christopher P.
Xia, Menghang
TI Profiling of the Tox21 Chemical Collection for Mitochondrial Function to
Identify Compounds that Acutely Decrease Mitochondrial Membrane
Potential
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID CYTOCHROME-C RELEASE; OXIDATIVE-PHOSPHORYLATION; ENVIRONMENTAL
CHEMICALS; LEUKEMIA-CELLS; DYSFUNCTION; MECHANISM; TOXICITY; APOPTOSIS;
BRYOSTATIN-1; CYTOTOXICITY
AB BACKGROUND: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases.
OBJECTIVES: We sought to identify individual chemicals and general structural features associated with changes in mitochondrial membrane potential (MMP). Methods: We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (similar to 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells.
RESULTS: Approximately 11% of the compounds (913 unique compounds) decreased MMP after 1 hr of treatment without affecting cell viability (ATP content). In addition, 309 compounds decreased MMP over a concentration range that also produced measurable cyto-toxicity [half maximal inhibitory concentration (IC50) in MMP assay/IC50 in viability assay <= 3; p < 0.05]. More than 11% of the structural clusters that constitute the Tox21 library (76 of 651 clusters) were significantly enriched for compounds that decreased the MMP.
CONCLUSIONS: Our multiplexed qHTS approach allowed us to generate a robust and reliable data set to evaluate the ability of thousands of drugs and environmental compounds to decrease MMP. The use of structure-based clustering analysis allowed us to identify molecular features that are likely responsible for the observed activity.
C1 [Attene-Ramos, Matias S.; Huang, Ruili; Michael, Sam; Simeonov, Anton; Austin, Christopher P.; Xia, Menghang] NIH, Natl Ctr Advancing Translat Sci, US Dept HHS, Bethesda, MD 20892 USA.
[Witt, Kristine L.; Tice, Raymond R.] NIEHS, Div Natl Toxicol Program, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
[Richard, Ann] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Xia, MH (reprint author), NIH, Natl Ctr Advancing Translat Sci, 9800 Med Ctr Dr, Bethesda, MD 20892 USA.
EM mxia@mail.nih.gov
FU National Institute of Environmental Health Sciences (NIEHS)/Division of
the National Toxicology Program [IAG Y2-ES-7020-01]
FX This work was supported through interagency agreement IAG Y2-ES-7020-01
from the National Institute of Environmental Health Sciences
(NIEHS)/Division of the National Toxicology Program to the National
Center for Advancing Translational Sciences, NIH.
NR 45
TC 13
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U1 5
U2 21
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JAN
PY 2015
VL 123
IS 1
BP 49
EP 56
DI 10.1289/ehp.1408642
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AY1YF
UT WOS:000347385000013
PM 25302578
ER
PT J
AU Zhang, XS
Izaurralde, RC
Manowitz, DH
Sahajpal, R
West, TO
Thomson, AM
Xu, M
Zhao, K
LeDuc, SD
Williams, JR
AF Zhang, Xuesong
Izaurralde, Roberto C.
Manowitz, David H.
Sahajpal, Ritvik
West, Tristram O.
Thomson, Allison M.
Xu, Min
Zhao, Kaiguang
LeDuc, Stephen D.
Williams, Jimmy R.
TI Regional scale cropland carbon budgets: Evaluating a geospatial
agricultural modeling system using inventory data
SO ENVIRONMENTAL MODELLING & SOFTWARE
LA English
DT Article
DE Agriculture; Carbon; Climate change; EPIC; Geospatial modeling; Parallel
computing
ID CLIMATE-CHANGE IMPACTS; ORGANIC-CARBON; INTEGRATED ASSESSMENT; SOIL
CARBON; LONG-TERM; CONTERMINOUS USA; UNITED-STATES; RIVER-BASIN;
LAND-USE; DYNAMICS
AB Accurate quantification and clear understanding of regional scale cropland carbon (C) cycling is critical for designing effective policies and management practices that can contribute toward stabilizing atmospheric CO2 concentrations. However, extrapolating site-scale observations to regional scales represents a major challenge confronting the agricultural modeling community. This study introduces a novel geospatial agricultural modeling system (GAMS) exploring the integration of the mechanistic Environmental Policy Integrated Climate model, spatially-resolved data, surveyed management data, and supercomputing functions for cropland C budgets estimates. This modeling system creates spatially-explicit modeling units at a spatial resolution consistent with remotely-sensed crop identification and assigns cropping systems to each of them by geo-referencing surveyed crop management information at the county or state level. A parallel computing algorithm was also developed to facilitate the computationally intensive model runs and output post-processing and visualization. We evaluated GAMS against National Agricultural Statistics Service (NASS) reported crop yields and inventory estimated county-scale cropland C budgets averaged over 2000-2008. We observed good overall agreement, with spatial correlation of 0.89, 0.90, 0.41, and 0.87, for crop yields, Net Primary Production (NPP), Soil Organic C (SOC) change, and Net Ecosystem Exchange (NEE), respectively. However, we also detected notable differences in the magnitude of NPP and NEE, as well as in the spatial pattern of SOC change. By performing crop-specific annual comparisons, we discuss possible explanations for the discrepancies between GAMS and the inventory method, such as data requirements, representation of agroecosystem processes, completeness and accuracy of crop management data, and accuracy of crop area representation. Based on these analyses, we further discuss strategies to improve GAMS by updating input data and by designing more efficient parallel computing capability to quantitatively assess errors associated with the simulation of C budget components. The modularized design of the GAMS makes it flexible to be updated and adapted for different agricultural models so long as they require similar input data, and to be linked with socio-economic models to understand the effectiveness and implications of diverse C management practices and policies. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Zhang, Xuesong; Manowitz, David H.; West, Tristram O.; Thomson, Allison M.] Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA.
[Zhang, Xuesong; Manowitz, David H.; West, Tristram O.; Thomson, Allison M.] Univ Maryland, College Pk, MD 20740 USA.
[Izaurralde, Roberto C.; Sahajpal, Ritvik] Univ Maryland, Dept Geog Sci, College Pk, MD 20740 USA.
[Xu, Min] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA.
[Zhao, Kaiguang] Ohio State Univ, Sch Environm & Nat Resources, Ohio Agr Res & Dev Ctr, Wooster, OH 44691 USA.
[LeDuc, Stephen D.] US EPA, Natl Ctr Environm Assessment, Arlington, VA 22202 USA.
[Izaurralde, Roberto C.; Williams, Jimmy R.] Texas A&M AgriLife Res & Extens Ctr, Temple, TX 76502 USA.
RP Zhang, XS (reprint author), Pacific NW Natl Lab, Joint Global Change Res Inst, College Pk, MD 20740 USA.
EM xuesong.zhang@pnnl.gov
RI zhang, xuesong/B-7907-2009; Zhao, Kaiguang/D-1172-2010;
OI Xu, Min/0000-0003-3443-0300
FU DOE Great Lakes Bioenergy Research Center (DOE BER Office of Science)
[DE-FC02-07ER64494, KP1601050, DOE EERE OBP 20469-19145]; NASA, North
American Carbon Program [NNH12AU03I]; New Investigator Program (NIP)
[NNH13ZDA001N]
FX We sincerely appreciate the valuable comments provided by the three
anonymous reviewers, which have greatly improved the quality of this
manuscript. This work was partially funded by the DOE Great Lakes
Bioenergy Research Center (DOE BER Office of Science DE-FC02-07ER64494,
DOE BER Office of Science KP1601050, DOE EERE OBP 20469-19145), and NASA
as part of the North American Carbon Program (NNH12AU03I) and the New
Investigator Program (NIP) (NNH13ZDA001N). The views expressed here are
those of the authors and do not necessarily represent the views or
policies of the U.S. Environmental Protection Agency.
NR 78
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U1 2
U2 38
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1364-8152
EI 1873-6726
J9 ENVIRON MODELL SOFTW
JI Environ. Modell. Softw.
PD JAN
PY 2015
VL 63
BP 199
EP 216
DI 10.1016/j.envsoft.2014.10.005
PG 18
WC Computer Science, Interdisciplinary Applications; Engineering,
Environmental; Environmental Sciences
SC Computer Science; Engineering; Environmental Sciences & Ecology
GA AY1OT
UT WOS:000347362900016
ER
PT J
AU Sengupta, D
Mukherjee, R
Sikdar, SK
AF Sengupta, Debalina
Mukherjee, Rajib
Sikdar, Subhas K.
TI Environmental Sustainability of Countries Using the UN MDG Indicators by
Multivariate Statistical Methods
SO ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY
LA English
DT Article
DE Aggregate Index Method; Euclidean Distance Method; Partial Least Squares
Variable Importance in Projection; United Nations Millennium Development
Goals; sustainability; sustainability indicators
AB The objective of the article is to show that indicator aggregation coupled with the use of a multivariate statistical analysis applied to the environmental sustainability indicator data of the UN Millennium Goals (MDG) can allow important inferences to be made. Goal 7 of the UN MDG aims to assess environmental sustainability by ten indicators, the dominant among them being emissions of carbon dioxide equivalent. The data is available over a period of 20 years. We used an aggregate index method to combine the various indicator values into a single index, and studied the trends of countries over the years. We have also compared among two arbitrarily chosen groups of OECD and non-OECD countries, and shown how these countries have performed among themselves and as a combined group over the time period. Using the multivariate statistical method of Partial Least Squares Variable Importance in Projection (PLS-VIP), we showed how to find the key indicators from the larger set and their relative importance over the years. Important results from our research include ranking of countries according to their overall environmental performance in a particular group. The PLS-VIP method showed that certain indicators have shifted in their importance in influencing their overall environmental performance, while others have remained relatively insignificant over the 20-year period. 2014 American Institute of Chemical Engineers Environ Prog, 2014 (c) 2014 American Institute of Chemical Engineers Environ Prog, 34: 198-206, 2015
C1 [Sengupta, Debalina; Mukherjee, Rajib; Sikdar, Subhas K.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Sikdar, SK (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM sikdar.subhas@epa.gov
FU EPA Office of Research and Development; Office of Research and
Development, National Risk Management Research Laboratory, U.S.
Environmental Protection Agency
FX The work presented here was funded by the EPA Office of Research and
Development. This project was supported in part by an appointment to the
Research Participation Program at the Office of Research and
Development, National Risk Management Research Laboratory, U.S.
Environmental Protection Agency, administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and EPA. The supplementary information
provided with this paper contains an excel spreadsheet where a reader
can access the data used to generate the figures in this paper. The
Matlab (R) code used to generate the data is available upon request from
the authors.
NR 16
TC 6
Z9 6
U1 1
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1944-7442
EI 1944-7450
J9 ENVIRON PROG SUSTAIN
JI Environ. Prog. Sustain. Energy
PD JAN
PY 2015
VL 34
IS 1
BP 198
EP 206
DI 10.1002/ep.11963
PG 9
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Engineering, Chemical; Engineering, Industrial; Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA AY1CP
UT WOS:000347331300025
ER
PT J
AU Lockey, JE
Redlich, CA
Streicher, R
Pfahles-Hutchens, A
Hakkinen, PJ
Ellison, GL
Harber, P
Utell, M
Holland, J
Comai, A
White, M
AF Lockey, James E.
Redlich, Carrie A.
Streicher, Robert
Pfahles-Hutchens, Andrea
Hakkinen, Pertti (Bert) J.
Ellison, Gary L.
Harber, Philip
Utell, Mark
Holland, John
Comai, Andrew
White, Marc
TI Isocyanates and Human Health Multistakeholder Information Needs and
Research Priorities
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID METHYLENE DIPHENYL DIISOCYANATE; COLLISION REPAIR INDUSTRY; OCCUPATIONAL
ASTHMA; TOLUENE DIISOCYANATE; EXPOSURE LIMITS; SKIN EXPOSURE;
POLYURETHANE; SURVEILLANCE
AB Objectives: To outline the knowledge gaps and research priorities identified by a broad base of stakeholders involved in the planning and participation of an international conference and research agenda workshop on isocyanates and human health held in Potomac, Maryland, in April 2013. Methods: A multimodal iterative approach was used for data collection including preconference surveys, review of a 2001 consensus conference on isocyanates, oral and poster presentations, focused break-out sessions, panel discussions, and postconference research agenda workshop. Results: Participants included representatives of consumer and worker health, health professionals, regulatory agencies, academic and industry scientists, labor, and trade associations. Conclusions: Recommendations were summarized regarding knowledge gaps and research priorities in the following areas: worker and consumer exposures; toxicology, animal models, and biomarkers; human cancer risk; environmental exposure and monitoring; and respiratory epidemiology and disease, and occupational health surveillance.
C1 [Lockey, James E.] Univ Cincinnati, Div Occupat & Environm Med, Dept Environm Hlth, Pulm Div,Dept Internal Med,Coll Med, Cincinnati, OH 45267 USA.
[Redlich, Carrie A.] Yale Univ, Sch Med, Yale Occupat & Environm Med, New Haven, CT USA.
[Streicher, Robert] NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
[Pfahles-Hutchens, Andrea] US EPA, Risk Assessment Div, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA.
[Hakkinen, Pertti (Bert) J.] NIH, Off Clin Toxicol, Specialized Informat Serv, Natl Lib Med, Bethesda, MD 20892 USA.
[Ellison, Gary L.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Harber, Philip] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA.
[Utell, Mark] Univ Rochester, Med Ctr, Rochester, NY 14627 USA.
[Holland, John] Holland Associates, Palo Alto, CA USA.
[Comai, Andrew] UAW Hlth & Safety, Int Union, Detroit, MI USA.
[White, Marc] Univ British Columbia, Dept Family Practice, Vancouver, BC V5Z 1M9, Canada.
[White, Marc] Canadian Inst Relief Pain & Disabil, Vancouver, BC, Canada.
RP Lockey, JE (reprint author), Univ Cincinnati, Coll Med, Div Occupat & Environm Med, Dept Environm Hlth, 3223 Eden Ave, Cincinnati, OH 45267 USA.
EM lockeyje@ucmail.uc.edu
RI White, Marc/N-8404-2015; Hakkinen, Pertti/G-4803-2016;
OI Hakkinen, Pertti/0000-0002-8295-9738; White, Marc/0000-0001-7623-1268
FU National Institutes of Health, National Cancer Institute; Canadian
Institutes for Health Research-Institute of Cancer Research; University
of Cincinnati College of Medicine
FX National Institutes of Health, National Cancer Institute; Canadian
Institutes for Health Research-Institute of Cancer Research; and
University of Cincinnati College of Medicine.
NR 30
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U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JAN
PY 2015
VL 57
IS 1
BP 44
EP 51
DI 10.1097/JOM.0000000000000278
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AY3IP
UT WOS:000347477900010
PM 25563538
ER
PT J
AU Daston, G
Knight, DJ
Schwarz, M
Gocht, T
Thomas, RS
Mahony, C
Whelan, M
AF Daston, George
Knight, Derek J.
Schwarz, Michael
Gocht, Tilman
Thomas, Russell S.
Mahony, Catherine
Whelan, Maurice
TI SEURAT: Safety Evaluation Ultimately Replacing Animal
Testing-Recommendations for future research in the field of predictive
toxicology
SO ARCHIVES OF TOXICOLOGY
LA English
DT Article
DE Critical biological targets; Adverse outcome pathways; Safety
assessment; Read-across; Ab initio prediction
ID HEALTH-RISK ASSESSMENT; TOXCAST PROGRAM; FRAMEWORK; CHEMICALS; UPDATE;
READ
AB The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained in SEURAT-1 and appreciating international advancement in both basic and regulatory science, we reflect here on how SEURAT should evolve and propose that further research and development should be directed along two complementary and interconnecting work streams. The first work stream would focus on developing new 'paradigm' approaches for regulatory science. The goal here is the identification of 'critical biological targets' relevant for toxicity and to test their suitability to be used as anchors for predicting toxicity. The second work stream would focus on integration and application of new approach methods for hazard (and risk) assessment within the current regulatory 'paradigm', aiming for acceptance of animal-free testing strategies by regulatory authorities (i.e. translating scientific achievements into regulation). Components for both work streams are discussed and may provide a structure for a future research programme in the field of predictive toxicology.
C1 [Daston, George] Procter & Gamble Co, Cent Prod Safety Dept, Mason, OH 45040 USA.
[Knight, Derek J.] European Chem Agcy, Helsinki 00121, Finland.
[Schwarz, Michael; Gocht, Tilman] Univ Tubingen, Dept Toxicol, Inst Expt & Clin Pharmacol & Toxicol, D-72074 Tubingen, Germany.
[Thomas, Russell S.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Mahony, Catherine] Procter & Gamble Tech Ctr Ltd, Egham TW20 9NW, Surrey, England.
[Whelan, Maurice] Commiss European Communities, Joint Res Ctr, IHCP, I-21027 Ispra, VA, Italy.
RP Schwarz, M (reprint author), Univ Tubingen, Dept Toxicol, Inst Expt & Clin Pharmacol & Toxicol, Wilhelmstr 56, D-72074 Tubingen, Germany.
EM Michael.schwarz@uni-tuebingen.de
OI Gocht, Tilma/0000-0002-2491-2050
FU European Community [267044]; Cosmetics Europe
FX This work has received funding from the European Community's Seventh
Framework Programme (FP7/2007-2013) under grant agreement no 267044
(project acronym 'COACH') and has received financing from Cosmetics
Europe.
NR 22
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PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD JAN
PY 2015
VL 89
IS 1
BP 15
EP 23
DI 10.1007/s00204-014-1421-5
PG 9
WC Toxicology
SC Toxicology
GA AY0KZ
UT WOS:000347286700003
PM 25433540
ER
PT J
AU Lorber, M
Eaglesham, GE
Hobson, P
Toms, LML
Mueller, JF
Thompson, JS
AF Lorber, M.
Eaglesham, G. E.
Hobson, P.
Toms, L. -M. L.
Mueller, J. F.
Thompson, J. S.
TI The effect of ongoing blood loss on human serum concentrations of
perfluorinated acids
SO CHEMOSPHERE
LA English
DT Article
DE PFOS; PFOA; Menstruation; Elimination; Blood loss; PK model
ID PERFLUOROOCTANE SULFONATE; WOMEN; POPULATION; AMERICANS; EXPOSURE
AB Perfluorinated alkyl acids (PFAAs) have been detected in serum at low concentrations in background populations. Higher concentrations haven been observed in adult males compared to females, with a possible explanation that menstruation offers females an additional elimination route. In this study, we examined the significance of blood loss as an elimination route of PFAAs. Pooled serum samples were collected from individuals undergoing a medical procedure involving ongoing blood withdrawal called venesection, Concentrations from male venesection patients were approximately 40% lower than males in the general population for perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). A simple pharmacokinetic model was used to test the hypothesis that blood loss could explain why adult males have higher concentrations of PFAAs than females, and why males undergoing venesections had lower concentrations compared to males in the general population. The model application generally supported these hypotheses showing that venesection might reduce blood serum concentrations by 37% (PFOA) and 53% (PFOS) compared to the observed difference of 44% and 37%. Menstruation was modeled to show a 22% reduction in PFOA serum concentrations compared to a 24% difference in concentrations between males and females in the background population. Uncertainties in the modeling and the data are identified and discussed. Published by Elsevier Ltd.
C1 [Lorber, M.] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Eaglesham, G. E.] Queensland Hlth & Forens Sci Serv, Special Serv Organ Grp, Coopers Plains, Qld 4108, Australia.
[Hobson, P.] Sullivan Niccolaides Pathol, Indooroopilly, Qld 4068, Australia.
[Toms, L. -M. L.] Queensland Univ Technol, Sch Clin Sci, Brisbane, Qld 4001, Australia.
[Toms, L. -M. L.] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia.
[Mueller, J. F.; Thompson, J. S.] Univ Queensland, Natl Res Ctr Environm Toxicol Entox, Coopers Plains, Qld 4108, Australia.
RP Lorber, M (reprint author), US EPA, Off Res & Dev, 1200 Penn Ave, Washington, DC 20460 USA.
EM lorber.matthew@epa.gov
RI Mueller, Jochen/C-6241-2008; Toms, Leisa-Maree/C-9530-2009;
OI Toms, Leisa-Maree/0000-0002-1444-1638; Mueller,
Jochen/0000-0002-0000-1973
FU Australian Research Council (ARC) Future Fellowship [FF120100546]; ARC
Discovery Early Career Researcher Award [DE120100161]; Queensland Health
FX J.F. Mueller is funded by Australian Research Council (ARC) Future
Fellowship (FF120100546). L.-M.L. Toms is funded by an ARC Discovery
Early Career Researcher Award (DE120100161). The National Research
Centre for Environmental Toxicology is co-funded by Queensland Health.
The authors are grateful for the statistical support provided by John
Fox of the United States Environmental Protection Agency.
NR 23
TC 9
Z9 9
U1 3
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2015
VL 118
BP 170
EP 177
DI 10.1016/j.chemosphere.2014.07.093
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AX5GC
UT WOS:000346953700024
PM 25180653
ER
PT J
AU Tumburu, L
Andersen, CP
Rygiewicz, PT
Reichman, JR
AF Tumburu, Laxminath
Andersen, Christian P.
Rygiewicz, Paul T.
Reichman, Jay R.
TI PHENOTYPIC AND GENOMIC RESPONSES TO TITANIUM DIOXIDE AND CERIUM OXIDE
NANOPARTICLES IN ARABIDOPSIS GERMINANTS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Arabidopsis thaliana germinants; Transcriptional responses; Development;
Nano-ceria; Nano-titania
ID THALIANA GENE-EXPRESSION; ENGINEERED NANOPARTICLES; CEO2 NANOPARTICLES;
SEED-GERMINATION; DNA-DAMAGE; PLANTS; TOXICITY; STRESS; TIO2; ZNO
AB The effects of exposure to nanoparticles of titanium dioxide (nano-titanium) and cerium oxide (nano-cerium) on gene expression and growth in Arabidopsis thaliana germinants were studied by using microarrays and quantitative real-time polymerase chain reaction (qPCR), and by evaluating germinant phenotypic plasticity. Exposure to 12 d of either nano-titania or nano-ceria altered the regulation of 204 and 142 genes, respectively. Genes induced by the nanoparticles mainly include ontology groups annotated as stimuli responsive, including both abiotic (oxidative stress, salt stress, water transport) and biotic (respiratory burst as a defense against pathogens) stimuli. Further analysis of the differentially expressed genes indicates that both nanoparticles affected a range of metabolic processes (deoxyribonucleic acid [DNA] metabolism, hormone metabolism, tetrapyrrole synthesis, and photosynthesis). Individual exposures to the nanoparticles increased percentages of seeds with emergent radicles, early development of hypocotyls and cotyledons, and those with fully grown leaves. Although there were distinct differences between the nanoparticles in their affect on molecular mechanisms attributable to enhancing germinant growth, both particles altered similar suites of genes related to various pathways and processes related to enhanced growth. Environ Toxicol Chem 2015;34:70-83. Published 2014 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
C1 [Tumburu, Laxminath] Western Ecol Div, Natl Res Council, Natl Hlth & Environm Effects Res Lab, US Environm Protect Agcy, Corvallis, OR USA.
[Andersen, Christian P.; Rygiewicz, Paul T.; Reichman, Jay R.] Western Ecol Div, Natl Hlth & Environm Effects Res Lab, US Environm Protect Agcy, Corvallis, OR USA.
RP Tumburu, L (reprint author), Western Ecol Div, Natl Res Council, Natl Hlth & Environm Effects Res Lab, US Environm Protect Agcy, Corvallis, OR 97333 USA.
EM lax.tumburu@nih.gov
FU US Environmental Protection Agency, Western Ecology Division Laboratory
FX We thank J. Betts for preparing the nanoparticle suspensions and
determining suspension characteristics and L. Pokhrel for helping us
obtain the TEM images and physical diameters of the ENPs. We also thank
the Genomic Research Core, National Health and Environmental Effects
Research Laboratory (NHEERL), US Environmental Protection Agency, for
processing the microarrays. The present study was performed while L.
Tumburu held a National Research Council Research Associateship Award at
the US Environmental Protection Agency, Western Ecology Division
Laboratory.
NR 48
TC 7
Z9 7
U1 5
U2 50
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2015
VL 34
IS 1
BP 70
EP 83
DI 10.1002/etc.2756
PG 14
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AX2QT
UT WOS:000346789800010
PM 25242526
ER
PT J
AU Johnson, BR
Weaver, PC
Nietch, CT
Lazorchak, JM
Struewing, KA
Funk, DH
AF Johnson, Brent R.
Weaver, Paul C.
Nietch, Christopher T.
Lazorchak, James M.
Struewing, Katherine A.
Funk, David H.
TI ELEVATED MAJOR ION CONCENTRATIONS INHIBIT LARVAL MAYFLY GROWTH AND
DEVELOPMENT
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Centroptilum; Conductivity; Neocloeon; Total dissolved solids; Toxicity
ID FRESH-WATER INVERTEBRATES; CENTROPTILUM-TRIANGULIFER; COAL-MINE;
TOXICITY; STREAM; EPHEMEROPTERA; BIOASSAYS; RESPONSES; SALINITY;
EXPOSURE
AB Anthropogenic disturbances, including those from developing energy resources, can alter stream chemistry significantly by elevating total dissolved solids. Field studies have indicated that mayflies (Order Ephemeroptera) are particularly sensitive to high total dissolved solids. In the present study, the authors measured 20-d growth and survivorship of larval Neocloeon triangulifer exposed to a gradient of brine salt (mixed NaCl and CaCl2) concentrations. Daily growth rates were reduced significantly in all salt concentrations above the control (363 mu Scm(-1)) and larvae in treatments with specific conductance >812 mu Scm(-1) were in comparatively earlier developmental stages (instars) at the end of the experiment. Survivorship declined significantly when specific conductance was >1513 mu Scm(-1) and the calculated 20-d 50% lethal concentration was 2866 mu Scm(-1). The present study's results provide strong experimental evidence that elevated ion concentrations similar to those observed in developing energy resources, such as oil and gas drilling or coal mining, can adversely affect sensitive aquatic insect species. Environ Toxicol Chem 2015;34:167-172. (c) 2014 SETAC
C1 [Johnson, Brent R.; Lazorchak, James M.] Natl Exposure Res Lab, United States Environm Protect Agcy, Cincinnati, OH USA.
[Weaver, Paul C.; Struewing, Katherine A.] McConnell Grp, Cincinnati, OH USA.
[Nietch, Christopher T.] Natl Risk Management Lab, United States Environm Protect Agcy, Cincinnati, OH USA.
[Funk, David H.] Stroud Water Res Ctr, Avondale, PA USA.
RP Johnson, BR (reprint author), Natl Exposure Res Lab, United States Environm Protect Agcy, Cincinnati, OH 45268 USA.
EM johnson.brent@epa.gov
OI Lazorchak, James/0000-0002-7354-7571
NR 38
TC 6
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U1 8
U2 28
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2015
VL 34
IS 1
BP 167
EP 172
DI 10.1002/etc.2777
PG 6
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AX2QT
UT WOS:000346789800021
PM 25307284
ER
PT J
AU Sanchez-Huerta, K
Pacheco-Rosado, J
Gilbert, ME
AF Sanchez-Huerta, K.
Pacheco-Rosado, J.
Gilbert, M. E.
TI Adult Onset-Hypothyroidism: Alterations in Hippocampal Field Potentials
in the Dentate Gyrus are Largely Associated with Anaesthesia-Induced
Hypothermia
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE thyroid; propylthiouracil; adult onset hypothryoidism; hippocampus;
synaptic transmission; hypothermia
ID LONG-TERM POTENTIATION; IMPAIRS SYNAPTIC-TRANSMISSION; THYROID-HORMONE
INSUFFICIENCY; BRAIN TEMPERATURE; RAT HIPPOCAMPUS; PROPYLTHIOURACIL;
PLASTICITY; PATHWAY; LTP; CA1
AB Thyroid hormone (TH) is essential for a number of physiological processes and is particularly critical during nervous system development. The hippocampus is strongly implicated in cognition and is sensitive to developmental hypothyroidism. The impact of TH insufficiency in the foetus and neonate on hippocampal synaptic function has been fairly well characterised. Although adult onset hypothyroidism has also been associated with impairments in cognitive function, studies of hippocampal synaptic function with late onset hypothyroidism have yielded inconsistent results. In the present study, we report hypothyroidism induced by the synthesis inhibitor propylthiouracil (10p.p.m., 0.001%, minimum of 4weeks), resulted in marginal alterations in excitatory postsynaptic potential (EPSP) and population spike (PS) amplitude in the dentate gyrus measured in vivo. No effects were seen in tests of short-term plasticity, and a minor enhancement of long-term potentiation of the EPSP slope was observed. The most robust synaptic alteration evident in hypothyroid animals was an increase in synaptic response latency, which was paralleled by a failure to maintain normal body temperature under anaesthesia, despite warming on a heating pad. Latency shifts could be reversed in hypothyroid animals by increasing the external heat source and, conversely, synaptic delays could be induced in control animals by removing the heat source, with a consequent drop in body and brain temperature. Thermoregulation is TH- dependent, and anaesthesia necessary for surgical procedures posed a thermoregulatory challenge that was differentially met in control and hypothyroid animals. Minor increases in field potential EPSP slope, decreases in PS amplitudes and increased latencies are consistent with previous reports of hypothermia in naive control rats. We conclude that failures in thyroid-dependent temperature regulation rather than direct action of TH in synaptic physiology are responsible for the observed effects. These findings stand in contrast to the synaptic impairments observed in adult offspring following developmental TH insufficiency, and emphasise the need to control for the potential unintended consequences of hypothermia in the interpretation of hypothyroid-induced changes in physiological systems, most notably synaptic transmission.
C1 [Sanchez-Huerta, K.; Pacheco-Rosado, J.] IPN, Dept Fisiol Mauricio Russek, Escuela Nacl Ciencias Biol, Mexico City 07738, DF, Mexico.
[Gilbert, M. E.] US EPA, Tox Assessment Div, Neurotoxicol Branch, Res Triangle Pk, NC 27711 USA.
[Sanchez-Huerta, K.; Pacheco-Rosado, J.] Natl Inst Pediat, Lab Neurochem, Mexico City, DF, Mexico.
RP Gilbert, ME (reprint author), US EPA, Tox Assessment Div MD B105 05, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM gilbert.mary@epa.gov
NR 42
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U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD JAN
PY 2015
VL 27
IS 1
BP 8
EP 19
DI 10.1111/jne.12229
PG 12
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AX1XC
UT WOS:000346735900002
PM 25327136
ER
PT J
AU Ogg, C
AF Ogg, Clayton
TI Compliance programs' feasibility for reducing worldwide loss of forests
and other ecosystems
SO JOURNAL OF SOIL AND WATER CONSERVATION
LA English
DT Editorial Material
C1 [Ogg, Clayton] USDA, Washington, DC USA.
[Ogg, Clayton] US EPA, Washington, DC USA.
NR 22
TC 0
Z9 0
U1 0
U2 0
PU SOIL WATER CONSERVATION SOC
PI ANKENY
PA 945 SW ANKENY RD, ANKENY, IA 50023-9723 USA
SN 0022-4561
EI 1941-3300
J9 J SOIL WATER CONSERV
JI J. Soil Water Conserv.
PD JAN-FEB
PY 2015
VL 70
IS 1
BP 19A
EP 22A
DI 10.2489/jswc.70.1.19A
PG 4
WC Ecology; Soil Science; Water Resources
SC Environmental Sciences & Ecology; Agriculture; Water Resources
GA AX8UI
UT WOS:000347183400003
ER
PT J
AU Korner-Nievergelt, F
Behr, O
Brinkmann, R
Etterson, MA
Huso, MMP
Dalthorp, D
Korner-Nievergelt, P
Roth, T
Niermann, I
AF Korner-Nievergelt, Fraenzi
Behr, Oliver
Brinkmann, Robert
Etterson, Matthew A.
Huso, Manuela M. P.
Dalthorp, Dan
Korner-Nievergelt, Pius
Roth, Tobias
Niermann, Ivo
TI Mortality estimation from carcass searches using the R-package carcass -
a tutorial
SO WILDLIFE BIOLOGY
LA English
DT Article
ID WIND FARMS; BAT FATALITY; BIRD; MODELS; PERSISTENCE; HYPOTHESES;
SURVIVAL; AREAS
AB This article is a tutorial for the R-package carcass. It starts with a short overview of common methods used to estimate mortality based on carcass searches. Then, it guides step by step through a simple example. First, the proportion of animals that fall into the search area is estimated. Second, carcass persistence time is estimated based on experimental data. Third, searcher efficiency is estimated. Fourth, these three estimated parameters are combined to obtain the probability that an animal killed is found by an observer. Finally, this probability is used together with the observed number of carcasses found to obtain an estimate for the total number of killed animals together with a credible interval.
C1 [Korner-Nievergelt, Fraenzi; Korner-Nievergelt, Pius] Oikostat GmbH, CH-6218 Ettiswil, Switzerland.
[Korner-Nievergelt, Fraenzi; Korner-Nievergelt, Pius] Swiss Ornithol Inst, Sempach, Switzerland.
[Behr, Oliver] Univ Erlangen Nurnberg, Chair Sensor Technol, DE-91054 Erlangen, Germany.
[Brinkmann, Robert] FrInaT, Freiburg Inst Appl Anim Ecol, DE-79106 Freiburg, Germany.
[Etterson, Matthew A.] US EPA, Duluth, MN 55804 USA.
[Huso, Manuela M. P.; Dalthorp, Dan] US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, Corvallis, OR 97331 USA.
[Roth, Tobias] Hintermann & Weber AG, CH-4153 Reinach, Switzerland.
[Niermann, Ivo] Leibniz Univ Hannover, Inst Environm Planning, DE-30419 Hannover, Germany.
RP Korner-Nievergelt, F (reprint author), Oikostat GmbH, Ausserdorf 43, CH-6218 Ettiswil, Switzerland.
EM fraenzi.korner@oikostat.ch
NR 34
TC 6
Z9 6
U1 5
U2 20
PU WILDLIFE BIOLOGY
PI RONDE
PA C/O JAN BERTELSEN, GRENAAVEJ 14, KALO, DK-8410 RONDE, DENMARK
SN 0909-6396
EI 1903-220X
J9 WILDLIFE BIOL
JI Wildlife Biol.
PD JAN
PY 2015
VL 21
IS 1
BP 30
EP 43
DI 10.2981/wlb.00094
PG 14
WC Ecology; Zoology
SC Environmental Sciences & Ecology; Zoology
GA AY2DK
UT WOS:000347398500004
ER
PT J
AU Wu, XM
Bennett, DH
Calafat, AM
Kato, K
Strynar, M
Andersen, E
Moran, RE
Tancredi, DJ
Tulve, NS
Hertz-Picciotto, I
AF Wu, Xiangmei (May)
Bennett, Deborah H.
Calafat, Antonia M.
Kato, Kayoko
Strynar, Mark
Andersen, Erik
Moran, Rebecca E.
Tancredi, Daniel J.
Tulve, Nicolle S.
Hertz-Picciotto, Irva
TI Serum concentrations of perfluorinated compounds (PFC) among selected
populations of children and Adults in California
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Perfluorinated compounds; Serum; Children; Within-family correlation;
Temporal variation
ID NATIONAL BIRTH COHORT; IN-HOUSE DUST; PERFLUOROOCTANE SULFONATE;
POLYFLUOROALKYL COMPOUNDS; POLYFLUORINATED COMPOUNDS; PERFLUOROALKYL
ACIDS; DIETARY EXPOSURE; INDOOR AIR; HALF-LIFE; CHEMICALS
AB Perfluorinated compounds (PFCs) have been widely used in industrial applications and consumer products. Their persistent nature and potential health impacts are of concern. Given the high cost of collecting serum samples, this study is to understand whether we can quantify PFC serum concentrations using factors extracted from questionnaire responses and indirect measurements, and whether a single serum measurement can be used to classify an individual's exposure over a one-year period. The study population included three demographic groups: young children (2-8 years old) (N=67), parents of young children (< 55 years old) (N=90), and older adults ( > 55 years old) (N=59). PFC serum concentrations, house dust concentrations, and questionnaires were collected. The geometric mean of perfluorooctane sulfonic acid (PFOS) was highest for the older adults. In contrast, the geometric mean of perfluorooctanoic acid (PFOA) was highest for children. Serum concentrations of the parent and the child from the same family were moderately correlated (Spearman correlation (r)=0.26-0.79, p <0.05), indicating common sources within a family. For adults, age, having occupational exposure or having used fire extinguisher, frequencies of consuming butter/margarine, pork, canned meat entres, tuna and white fish, freshwater fish, and whether they ate microwave popcorn were significantly positively associated with serum concentrations of individual PFCs. For children, residential dust concentrations, frequency of wearing waterproof clothes, frequency of having canned fish, hotdogs, chicken nuggets, French fries, and chips, and whether they ate microwave popcorn were significant positive predictors of individual PFC serum concentrations. In addition, the serum concentrations collected in a subset of young children (N=20) and the parents (N=42) one year later were strongly correlated (r=0.68-0.98, p <0.001) with the levels measured at the first visits, but showed a decreasing trend. Children had moderate correlation (r=0.43) between serum and dust concentrations. of PFOS, indicating indoor sources contribute to exposure. In conclusion, besides food intake, occupational exposure, consumer product use, and exposure to residential dust contribute to PFC exposure. The downward temporal trend of serum concentrations reflects the reduction of PFCs use in recent years while the year-to-year correlation indicates that a single serum measurement could be an estimate of exposure relative to the population for a one-year period in epidemiology studies. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Wu, Xiangmei (May); Bennett, Deborah H.; Moran, Rebecca E.; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Calafat, Antonia M.; Kato, Kayoko] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Strynar, Mark; Andersen, Erik] US EPA, Human Exposure & Atmospher Sci Div, Methods Dev & Applicat Branch, Durham, NC 27711 USA.
[Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA.
[Tulve, Nicolle S.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
RP Wu, XM (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, One Shields Ave,MS1C, Davis, CA 95616 USA.
EM xmwu@phs.ucdavis.edu; dhbennett@ucdavis.edu; aic7@cdc.gov; ktk2@cdc.gov;
Strynar.Mark@epa.gov; andersen.erik@epa.gov; rmoran@ucdavis.edu;
djtancredi@ucdavis.edu; Tulve.Nicolle@epa.gov; ihp@ucdavis.edu
RI Tancredi, Daniel/O-3381-2013
OI Tancredi, Daniel/0000-0002-3884-7907
FU U.S. Environmental Protection Agency (US EPA) [RD-83154001]; Autism
Speaks
FX This research was funded by a Science to Achieve Results (STAR) grant
#RD-83154001 from the U.S. Environmental Protection Agency (US EPA).
Environmental sample analysis was conducted by the U.S. EPA's Office of
Research and Development's National Exposure Research Laboratory, and
blood sample analysis was conducted by the Centers for Disease Control
and Prevention Laboratory (CDC). Data analysis was conducted with
funding from Autism Speaks.
NR 64
TC 16
Z9 16
U1 4
U2 56
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2015
VL 136
BP 264
EP 273
DI 10.1016/j.envres.2014.09.026
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX2DY
UT WOS:000346755000033
PM 25460645
ER
PT J
AU Yeh, HC
Lin, YS
Kuo, CC
Weidemann, D
Weaver, V
Fadrowski, J
Neu, A
Navas-Acien, A
AF Yeh, Hung-Chieh
Lin, Yu-Sheng
Kuo, Chin-Chi
Weidemann, Darcy
Weaver, Virginia
Fadrowski, Jeffrey
Neu, Alicia
Navas-Acien, Ana
TI Urine osmolality in the US population: Implications for environmental
biomonitoring
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Urine osmolality; Urine creatinine; Biomonitoring; Urine adequacy; Urine
dilution
ID PROTEIN-OSMOLALITY; ALBUMIN EXCRETION; CREATININE; CHILDREN; DISEASE;
VALIDITY; GUIDE; RATIO
AB Background: For many environmental chemicals, concentrations in spot urine samples are considered valid surrogates of exposure and internal dose. To correct for urine dilution, spot urine concentrations are commonly adjusted for urinary creatinine. There are, however, several concerns about the use of urine creatinine. While urine osmolality is an attractive alternative; its characteristics and determinants in the general population remain unknown. Our objective was to describe the determinants of urine osmolality and to contrast the difference between osmolality and creatinine in urine.
Methods: From the National Health and Nutrition Examination Survey (NHANES) (2009-2010), 10,769 participants aged 16 years or older with measured urine osmolality and creatinine were used in the analysis. Very dilute and very concentrated urine was defined as urine creatinine lower than 0.3 g/l and higher than 3 g/l, respectively. Linear and logistic regression analyses were performed to investigate the associations of interest.
Results: Urine osmolality and creatinine were highly correlated (Pearson correlation coefficient=0.75) and their respective median values were 648 mOsm/kg and 1.07 g/l. The prevalence of very dilute and very concentrated urine samples was 8.1% and 3.1%, respectively. Factors associated in the same direction with both urine osmolality and urine creatinine included age, sex, race, body mass index (BMI), hypertension, water intake, and blood osmolality. The magnitude of associations expressed as percent change was significantly stronger with creatinine than osmolality. Compared to urine creatinine, urine osmolality did not vary by diabetes status but was affected by daily total protein intake. Participants with chronic kidney disease (CKD) had significantly higher urine creatinine concentrations but lower urine osmolality. Both very dilute and concentrated urine were associated with a diverse array of socio-demographic, medical conditions, and dietary factors. For instance, females were approximately 3.3 times more likely to have urine over-dilution than male [the adjusted odds ratios (95% CI)=3.27 (2.10-5.10)].
Conclusion: Although the determinants of urine osmolality were generally similar to those of urine creatinine, the relative influence of socio-demographic and medical conditions was less on urine osmolality than on urine creatinine. Protocols for spot urine sample collection could recommend avoiding excessive and insufficient water intake before urine sampling to improve urine adequacy. The feasibility of adopting urine osmolality adjustment and water intake recommendations before providing spot urine samples for environmental biomonitoring merits further investigation. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Yeh, Hung-Chieh; Kuo, Chin-Chi] China Med Univ, China Med Univ Hosp, Kidney Inst, Taichung, Taiwan.
[Yeh, Hung-Chieh; Kuo, Chin-Chi] China Med Univ, China Med Univ Hosp, Dept Internal Med, Div Nephrol, Taichung, Taiwan.
[Yeh, Hung-Chieh; Kuo, Chin-Chi] China Med Univ, Coll Med, Taichung, Taiwan.
[Lin, Yu-Sheng] Univ N Texas, Hlth Sci Ctr, Dept Environm & Occupat Hlth, Ft Worth, TX USA.
[Kuo, Chin-Chi; Weidemann, Darcy; Fadrowski, Jeffrey; Navas-Acien, Ana] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Kuo, Chin-Chi; Weaver, Virginia; Navas-Acien, Ana] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA.
[Kuo, Chin-Chi; Weaver, Virginia; Navas-Acien, Ana] Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
[Weidemann, Darcy; Fadrowski, Jeffrey; Neu, Alicia] Johns Hopkins Med Inst, Dept Pediat, Div Nephrol, Baltimore, MD 21205 USA.
RP Kuo, CC (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
FU NIDDK NIH HHS [P30 DK079637]
NR 31
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U1 1
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2015
VL 136
BP 482
EP 490
DI 10.1016/j.envres.2014.09.009
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX2DY
UT WOS:000346755000058
PM 25460670
ER
PT J
AU Bateson, TF
Kopylev, L
AF Bateson, Thomas F.
Kopylev, Leonid
TI Influence of exposure assessment and parameterization on exposure
response. Aspects of epidemiologic cohort analysis using the Libby
Amphibole asbestos worker cohort
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE asbestos; exposure assessment; exposure modeling; Libby MT; lung cancer;
vermiculite
ID GUIDE RISK-ASSESSMENT; VERMICULITE MINERS; LUNG-CANCER; OCCUPATIONAL
EXPOSURES; TREMOLITE ACTINOLITE; MATHEMATICAL MODEL; POTENCY FACTORS;
FIBER BURDEN; MORTALITY; QUALITY
AB Recent meta-analyses of occupational epidemiology studies identified two important exposure data quality factors in predicting summary effect measures for asbestos-associated lung cancer mortality risk: sufficiency of job history data and percent coverage of work history by measured exposures. The objective was to evaluate different exposure parameterizations suggested in the asbestos literature using the Libby, MT asbestos worker cohort and to evaluate influences of exposure measurement error caused by historically estimated exposure data on lung cancer risks. Focusing on workers hired after 1959, when job histories were well-known and occupational exposures were predominantly based on measured exposures (85% coverage), we found that cumulative exposure alone, and with allowance of exponential decay, fit lung cancer mortality data similarly. Residence-time-weighted metrics did not fit well. Compared with previous analyses based on the whole cohort of Libby workers hired after 1935, when job histories were less well-known and exposures less frequently measured (47% coverage), our analyses based on higher quality exposure data yielded an effect size as much as 3.6 times higher. Future occupational cohort studies should continue to refine retrospective exposure assessment methods, consider multiple exposure metrics, and explore new methods of maintaining statistical power while minimizing exposure measurement error.
C1 [Bateson, Thomas F.; Kopylev, Leonid] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Bateson, TF (reprint author), US EPA, Natl Ctr Environm Assessment, 1200 Penn Ave NW,Mailcode 8623P, Washington, DC 20460 USA.
EM bateson.thomas@epa.gov
FU National Center for Environmental Assessment, US Environmental
Protection Agency
FX We are grateful to Patricia Sullivan of the National Institute for
Occupational Safety and Health, Danielle DeVoney of the US EPA's Office
of Solid Waste and Emergency Response and anonymous reviewers. No direct
funding for this work was received from any source; general support for
this work was provided by the National Center for Environmental
Assessment, US Environmental Protection Agency.
NR 34
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U1 1
U2 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JAN-FEB
PY 2015
VL 25
IS 1
BP 12
EP 17
DI 10.1038/jes.2014.3
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AW7GB
UT WOS:000346431500003
PM 24496219
ER
PT J
AU Davis, MJ
Janke, R
AF Davis, Michael J.
Janke, Robert
TI Influence of Network Model Detail on Estimated Health Effects of
Drinking Water Contamination Events
SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT
LA English
DT Article
DE Water distribution systems; Simulation; Water quality; Drinking water;
Public health
ID DISTRIBUTION-SYSTEMS
AB Network model detail can influence the accuracy of results from analyses of water distribution systems. Previous work has shown the limitations of skeletonized network models when considering water quality and hydraulic effects. Loss of model detail is potentially less important for aggregated effects such as the systemwide health effects associated with a contamination event, but has received limited attention. The influence of model detail on such effects is examined here by comparing results obtained for contamination events using three large network models and several skeletonized versions of the models. Loss of model detail decreases the accuracy of estimated aggregated adverse effects related to contamination events. It has the potential to have a large negative influence on the results of consequence assessments and the design of contamination warning systems. However, the adverse influence on analysis results can be minimized by restricting attention to high percentile effects (i.e.,95th percentile or higher).
C1 [Davis, Michael J.] Argonne Natl Lab, Div Environm Sci, Argonne, IL 60439 USA.
[Janke, Robert] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Davis, MJ (reprint author), Argonne Natl Lab, Div Environm Sci, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM mike_davis@anl.gov; janke.robert@epa.gov
FU U.S. Environmental Protection Agency's (EPA's) Office of Research and
Development; EPA under U.S. Department of Energy [DE-AC02-06CH11357]
FX The U.S. Environmental Protection Agency's (EPA's) Office of Research
and Development funded, managed, and participated in the research
described here under an interagency agreement. The views expressed in
this paper are those of the authors and do not necessarily reflect the
views or policies of EPA. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. Work at
Argonne National Laboratory was sponsored by the EPA under an
interagency agreement through U.S. Department of Energy Contract
DE-AC02-06CH11357.
NR 23
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U1 0
U2 4
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9496
EI 1943-5452
J9 J WATER RES PLAN MAN
JI J. Water Resour. Plan. Manage.-ASCE
PD JAN
PY 2015
VL 141
IS 1
AR UNSP 04014044
DI 10.1061/(ASCE)WR.1943-5452.0000436
PG 9
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA AW5WX
UT WOS:000346342800003
ER
PT J
AU Weber, MA
Ringold, PL
AF Weber, Matthew A.
Ringold, Paul L.
TI Priority river metrics for residents of an urbanized arid watershed
SO LANDSCAPE AND URBAN PLANNING
LA English
DT Article
DE Qualitative research; Focus groups; Depth interviews; Final ecosystem
services; Urban ecosystem services; River monitoring
ID SENSITIVE TOPICS; DECISION-MAKERS; DESERT CITY; RESTORATION;
PERCEPTIONS; INDICATORS; CORRIDORS; QUALITY; VALUES
AB In river and stream assessment and management, a persistent question is isolating appropriate indicators of resource condition. We employ qualitative research techniques to identify features of rivers and streams important to the general public in an urbanized arid watershed of the southwestern US, based on interview and focus group data. After detailed analysis of transcriptions, findings were member-checked with new study participants and further revised. Theme frequencies are reported to provide an indication of participants' informational priorities. Recurrent ecological themes were Water, Vegetation, and Fish and Wildlife; recurrent human themes were Garbage and Graffiti, Odor, Infrastructure, Other People, and Noise. Themes are further described along with illustrative quotes from participants. We interpret participant input into actionable metrics which could serve to track resource condition. Results are compared to previous research and current monitoring practice. The findings are particularly relevant for scientists and managers interested in the perspectives on rivers and streams held by residents of urbanized watersheds in arid landscapes. Published by Elsevier B.V.
C1 [Weber, Matthew A.; Ringold, Paul L.] US EPA, Off Res & Dev, Western Ecol Div, Corvallis, OR 97333 USA.
RP Weber, MA (reprint author), US EPA, Off Res & Dev, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA.
EM weber.matthew@epa.gov; ringold.paul@epa.gov
NR 50
TC 2
Z9 2
U1 5
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-2046
EI 1872-6062
J9 LANDSCAPE URBAN PLAN
JI Landsc. Urban Plan.
PD JAN
PY 2015
VL 133
BP 37
EP 52
DI 10.1016/j.landurbplan.2014.09.006
PG 16
WC Ecology; Environmental Studies; Geography; Geography, Physical; Urban
Studies
SC Environmental Sciences & Ecology; Geography; Physical Geography; Urban
Studies
GA AW8WQ
UT WOS:000346540600004
ER
PT J
AU Henderson, J
Rodgers, C
Jones, R
Smith, J
Strzepek, K
Martinich, J
AF Henderson, James
Rodgers, Charles
Jones, Russell
Smith, Joel
Strzepek, Kenneth
Martinich, Jeremy
TI Economic impacts of climate change on water resources in the coterminous
United States
SO MITIGATION AND ADAPTATION STRATEGIES FOR GLOBAL CHANGE
LA English
DT Article
DE Climate change; Impacts; Economic analysis; Mitigation policy; Water
demand; Water resources; Adaptation
ID CALIFORNIA; MANAGEMENT; RESPONSES; DROUGHT; MODEL
AB A national-scale simulation-optimization model was created to generate estimates of economic impacts associated with changes in water supply and demand as influenced by climate change. Water balances were modeled for the 99 assessment sub-regions, and are presented for 18 water resource regions in the United States. Benefit functions are developed for irrigated agriculture, municipal and domestic water use, commercial and industrial water use, and hydroelectric power generation. Environmental flows below minimal levels required for environmental needs are assessed a penalty. As a demonstration of concept for the model, future climate is projected using a climate model ensemble for two greenhouse gas (GHG) emissions scenarios: a business-as-usual (BAU) scenario in which no new GHG controls are implemented, and an exemplary mitigation policy (POL) scenario in which future GHG emissions are mitigated. Damages are projected to grow less during the 21st century under the POL scenario than the BAU scenario. The largest impacts from climate change are projected to be on non-consumptive uses (e.g., environmental flows and hydropower) and relatively lower-valued consumptive uses (e.g., agriculture), as water is reallocated during reduced water availability conditions to supply domestic, commercial, and industrial uses with higher marginal values. Lower GHG concentrations associated with a mitigation policy will result in a smaller rise in temperature and thus less extensive damage to some water resource uses. However, hydropower, environmental flow penalty, and agriculture were shown to be sensitive to the change in runoff as well.
C1 [Henderson, James; Jones, Russell; Smith, Joel] Stratus Consulting Inc, Boulder, CO 80306 USA.
[Rodgers, Charles] Asian Dev Bank, Mandaluyong City, Philippines.
[Strzepek, Kenneth] MIT, Cambridge, MA 02139 USA.
[Martinich, Jeremy] US EPA, Climate Change Div, Washington, DC 20460 USA.
RP Henderson, J (reprint author), Stratus Consulting Inc, POB 4059, Boulder, CO 80306 USA.
EM jhenderson@stratusconsulting.com
FU U.S. Environmental Protection Agency's (EPA's) Office of Atmospheric
Programs [EP-W-07-072]
FX We gratefully acknowledge the financial support of the U.S.
Environmental Protection Agency's (EPA's) Office of Atmospheric Programs
(Contract #EP-W-07-072).
NR 43
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Z9 3
U1 2
U2 54
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1381-2386
EI 1573-1596
J9 MITIG ADAPT STRAT GL
JI Mitig. Adapt. Strateg. Glob. Chang.
PD JAN
PY 2015
VL 20
IS 1
BP 135
EP 157
DI 10.1007/s11027-013-9483-x
PG 23
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AW6WK
UT WOS:000346406000007
ER
PT J
AU Erickson, DJ
Sulzberger, B
Zepp, RG
Austin, AT
AF Erickson, David J., III
Sulzberger, Barbara
Zepp, Richard G.
Austin, Amy T.
TI Effects of stratospheric ozone depletion, solar UV radiation, and
climate change on biogeochemical cycling: interactions and feedbacks
SO PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
LA English
DT Review
ID DISSOLVED ORGANIC-MATTER; PLANT LITTER DECOMPOSITION; CARBON-DIOXIDE
UPTAKE; ARCTIC SEA-ICE; MARINE-PHYTOPLANKTON; OCEAN ACIDIFICATION;
GREENHOUSE GASES; ATMOSPHERIC CO2; TIPPING POINTS; SURFACE WATERS
AB Climate change modulates the effects of solar UV radiation on biogeochemical cycles in terrestrial and aquatic ecosystems, particularly for carbon cycling, resulting in UV-mediated positive or negative feedbacks on climate. Possible positive feedbacks discussed in this assessment include: (i) enhanced UV-induced mineralisation of above ground litter due to aridification; (ii) enhanced UV-induced mineralisation of photoreactive dissolved organic matter (DOM) in aquatic ecosystems due to changes in continental runoff and ice melting; (iii) reduced efficiency of the biological pump due to UV-induced bleaching of coloured dissolved organic matter (CDOM) in stratified aquatic ecosystems, where CDOM protects phytoplankton from the damaging solar UV-B radiation. Mineralisation of organic matter results in the production and release of CO2, whereas the biological pump is the main biological process for CO2 removal by aquatic ecosystems. This paper also assesses the interactive effects of solar UV radiation and climate change on the biogeochemical cycling of aerosols and trace gases other than CO2, as well as of chemical and biological contaminants. Interacting effects of solar UV radiation and climate change on biogeochemical cycles are particularly pronounced at terrestrial-aquatic interfaces.
C1 [Erickson, David J., III] Oak Ridge Natl Lab, Comp Earth Sci Grp, Div Math & Comp Sci, Oak Ridge, TN 37831 USA.
[Sulzberger, Barbara] Eawag Swiss Fed Inst Aquat Sci & Technol, CH-8600 Dubendorf, Switzerland.
[Zepp, Richard G.] US EPA, Athens, GA 30605 USA.
[Austin, Amy T.] Univ Buenos Aires, Inst Invest Fisiol & Ecol Vinculadas Agr IFEVA, Buenos Aires, DF, Argentina.
[Austin, Amy T.] Univ Buenos Aires, CONICET, Buenos Aires, DF, Argentina.
RP Erickson, DJ (reprint author), Oak Ridge Natl Lab, Comp Earth Sci Grp, Div Math & Comp Sci, POB 2008,MS 6016, Oak Ridge, TN 37831 USA.
EM d.j.erickson@tds.net
OI Austin, Amy/0000-0002-7468-5861
FU U.S. Global Change Research Program; Oak Ridge National Laboratory;
Office of Science of the U.S. Department of Energy [DE-AC05-00OR22725];
Eawag: Swiss Federal Institute of Aquatic Science and Technology;
National Exposure Research Laboratory, Ecosystems Research Division,
U.S. Environmental Protection Agency; National Agency of Science and
Technology of Argentina (ANPCyT)
FX D. E. was supported by the U.S. Global Change Research Program and by
the Oak Ridge National Laboratory, which is supported by the Office of
Science of the U.S. Department of Energy under Contract Number
DE-AC05-00OR22725. B. S. was supported by Eawag: Swiss Federal Institute
of Aquatic Science and Technology. R. Z. was supported by the National
Exposure Research Laboratory, Ecosystems Research Division, U.S.
Environmental Protection Agency, and A. A. was supported by grants from
the National Agency of Science and Technology of Argentina (ANPCyT).
NR 251
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U1 12
U2 93
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1474-905X
EI 1474-9092
J9 PHOTOCH PHOTOBIO SCI
JI Photochem. Photobiol. Sci.
PY 2015
VL 14
IS 1
BP 127
EP 148
DI 10.1039/c4pp90036g
PG 22
WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Physical
SC Biochemistry & Molecular Biology; Biophysics; Chemistry
GA AW9HC
UT WOS:000346567000008
PM 25380348
ER
PT J
AU Ghimire, SR
Johnston, JM
AF Ghimire, Santosh R.
Johnston, John M.
BE Karvazy, K
Webster, VL
TI Traditional Knowledge of Rainwater Harvesting Compared to Five Modern
Case Studies
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
ID CLIMATE-CHANGE; WATER; SYSTEM; NEPAL
AB The water-energy-food nexus is receiving increased attention worldwide due to climate change and rising population. According to a projection of the United Nations, the global population is expected to increase by a factor of 1.3 by 2050- from 7.2 billion to 9.6-billion with corresponding demands for energy and food. Climate in the future is predicted to be warmer, with more frequent and intense rainfall as well as decreased rainfall reliability for agriculture in water-stressed regions. Rainwater harvesting (RWH) has been used to meet water demands for millennia. The historical context of RWH is still meaningful today and provides a more informed use of RWH as a climate change adaptation strategy. Our objective is to trace the development of RWH by comparing long-term use of hitis (water-spouts) in Nepal to five modern case studies from the U.S. in NY, FL, TX, IL, and CA.
C1 [Ghimire, Santosh R.] US EPA, ORISE, Off Res & Dev Ecosyst Res Div, Postdoctoral Res Participant, 960 Coll Stn Rd, Athens, GA 30605 USA.
[Johnston, John M.] US EPA, Off Res & Dev, Ecosyst Res Div, Athens, GA 30605 USA.
RP Ghimire, SR (reprint author), US EPA, ORISE, Off Res & Dev Ecosyst Res Div, Postdoctoral Res Participant, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM Ghimire.Santosh@epa.gov; Johnston.JohnM@epa.gov
NR 51
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Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 182
EP 193
PG 12
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300017
ER
PT J
AU Shilling, F
Khan, A
Juricich, R
Fong, V
Hodge, D
AF Shilling, Fraser
Khan, Abdul
Juricich, Rich
Fong, Vance
Hodge, Don
BE Karvazy, K
Webster, VL
TI Water Sustainability Indicators for California Water Management
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
AB The Department of Water Resources (DWR) recognizes the importance of long-term sustainability of the state's water systems. As part of the California Water Plan Update 2013, DWR collaboratively developed an analytical framework to quantify water resources sustainability indicators for California. The California Water Sustainability Indicators Framework brings together water sustainability indicators that will inform us about water system conditions and their relationships to ecosystems, social systems, and economic systems. The framework is a comprehensive system for measuring and reporting water sustainability at watershed, regional, and state scales, relative to quantified sustainability targets. An online tool was developed to contain an encyclopedia of over 1,800 sustainability indicators, as well as the results of the use of a select set of indicators at watershed, regional, and state scales as part of Water Plan Update 2013. The Framework is intended to support reporting of indicators to a wide array of water and environmental stakeholders, the public, and decision makers to build knowledge and to enhance adaptive decision making and policy change.
C1 [Shilling, Fraser] Univ Calif Davis, Environm Sci & Policy, Davis, CA 95616 USA.
[Khan, Abdul; Juricich, Rich] CA Dept Water Resources, Sacramento, CA 94236 USA.
[Fong, Vance] US EPA, Environm Indicator Program, San Francisco, CA 94105 USA.
[Hodge, Don] US EPA Reg, Agr Program, San Francisco, CA 94105 USA.
RP Shilling, F (reprint author), Univ Calif Davis, Environm Sci & Policy, Davis, CA 95616 USA.
EM fmshilling@ucdavis.edu; abdul.khan@water.ca.gov;
rich.juricich@water.ca.gov; Fong.Vance@EPA.Gov; hodge.don@epa.gov
NR 4
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 2341
EP 2349
PG 9
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300230
ER
PT J
AU Sherman, LS
Blum, JD
Dvonch, JT
Gratz, LE
Landis, MS
AF Sherman, Laura S.
Blum, Joel D.
Dvonch, J. Timothy
Gratz, Lynne E.
Landis, Matthew S.
TI The use of Pb, Sr, and Hg isotopes in Great Lakes precipitation as a
tool for pollution source attribution
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Heavy metals; Stable isotopes; Source attribution; Multivariate
statistical receptor modeling; Wet deposition
ID MERCURY WET DEPOSITION; FIRED POWER-PLANTS; MASS-INDEPENDENT
FRACTIONATION; NORTHEASTERN UNITED-STATES; ATMOSPHERIC HEAVY-METALS;
CHICAGO/GARY URBAN AREA; MONTANE FOREST SOILS; STRONTIUM ISOTOPES; LEAD
ISOTOPES; WEATHERING RATES
AB The anthropogenic emission and subsequent deposition of heavy metals including mercury (Hg) and lead (Pb) present human health and environmental concerns. Although it is known that local and regional sources of these metals contribute to deposition in the Great Lakes region, it is difficult to trace emissions from point sources to ithpacted sites. Recent studies suggest that metal isotope ratios may be useful for distinguishing between and tracing source emissions. We measured Pb, strontium (Sr), and Hg isotope ratios in daily precipitation samples that were collected at seven sites across the Great Lakes region between 2003 and 2007. Lead isotope ratios ((207)pb/(206)pb = 0.8062 to 0.8554) suggest that Pb deposition was influenced by coal combustion and processing of Mississippi Valley-Type Pb ore deposits. Regional differences in Sr isotope ratios (Sr-87/Sr-86 = 0.70859 to 0.71155) are likely related to coal fly ash and soil dust. Mercury isotope ratios (delta Hg-202 = -1.13 to 0.13%.) also varied among the sites, likely due to regional differences in coal isotopic composition, and fractionation occurring within industrial facilities and in the atmosphere. These data represent the first combined characterization of Pb, Sr, and Hg isotope ratios in precipitation collected across the Great Lakes region. We demonstrate the utility of multiple metal isotope ratios in parallel with traditional trace element multivariate statistical modeling to enable more complete pollution source attribution. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Sherman, Laura S.; Blum, Joel D.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA.
[Dvonch, J. Timothy] Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA.
[Gratz, Lynne E.] Univ Washington, Bothell, WA 98011 USA.
[Landis, Matthew S.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
RP Sherman, LS (reprint author), Univ Michigan, Dept Earth & Environm Sci, 1100 N Univ Ave, Ann Arbor, MI 48109 USA.
EM lsaylors@umich.edu
RI Landis, Matthew/P-5149-2014; Dvonch, Joseph/K-3632-2013
OI Landis, Matthew/0000-0002-8742-496X;
FU University of Michigan Water Center of the Graham Sustainability
Institute; University of Michigan [EPD05005]; Fred A. and Barbara M. Erb
Family Foundation; EPA through its Office of Research and Development
[R-82971601]
FX This work was supported in part by the University of Michigan Water
Center of the Graham Sustainability Institute, which receives funds from
the Fred A. and Barbara M. Erb Family Foundation and the University of
Michigan. The EPA through its Office of Research and Development
partially funded and participated in this research through cooperative
agreement R-82971601 and contract EPD05005 with the University of
Michigan. The views expressed in this manuscript are those of the
authors and do not necessarily reflect the views or policies of the EPA.
It has been subjected to Agency review and approved for publication.
Mention of trade names or commercial products does not constitute an
endorsement or recommendation for use. The authors are grateful to Jamie
Gleason, Marcus Johnson, and Ted Huston for analytical assistance as
well as Jim Barres, Frank Marsik, Emily White, Ali Kamal, Naima Hall,
and Bian Liu for their dedicated efforts in data collection and
interpretation. We also thank four anonymous reviewers for comments that
improved this manuscript. Finally, this research would not have been
possible without the oversight, vision, and commitment of the late Jerry
Keeler.
NR 130
TC 15
Z9 19
U1 11
U2 124
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD JAN 1
PY 2015
VL 502
BP 362
EP 374
DI 10.1016/j.scitotenv.2014.09.034
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU6RZ
UT WOS:000345730800039
PM 25265397
ER
PT J
AU Jauss, V
Johnson, M
Krull, E
Daub, M
Lehmann, J
AF Jauss, Verena
Johnson, Mark
Krull, Evelyn
Daub, Markus
Lehmann, Johannes
TI Pyrogenic carbon controls across a soil catena in the Pacific Northwest
SO CATENA
LA English
DT Article
DE Climate change; Fire; Pyrogenic carbon; Soil development; Soil organic
matter
ID SCOTS PINE FORESTS; BLACK CARBON; ORGANIC-CARBON; FIRE REGIMES; CLIMATE;
VEGETATION; OXIDATION; MOBILITY; CHARCOAL
AB Since turnover times of pyrogenic carbon (PyC) are substantially slower than those of other organic carbon input to soil, it is considered an important constituent of the global C cycle acting as a C sink. In the Pacific Northwest vegetation fires regularly produce PyC, but its accumulation in soils is poorly quantified. Using mid-infrared spectroscopy (MIR) and partial least-squares (PLS) analysis in conjunction with ultraviolet photo-oxidation followed by nuclear magnetic resonance spectroscopy (UV-NMR) techniques, PyC contents were quantified for samples from soil profiles along a vegetation gradient. Sample locations included different forest types as well as sites under agricultural use. While PyC was most prevalent in the first 0.2 m with 7-24% of total soil organic C (SOC), it could be found in the subsoil of all locations. However, PyC concentrations did not change consistently with soil depth. Stock sizes were lowest at the Turkey Farm (0.71 kg m(-2); 10% of SOC) and Organic Growers Farm (1.14 kg m(-2); 8% of SOC) sites, presumably due to the pervasive combustion of grass and cereals. Among the forested sites, lower stocks were observed at sites with higher mean annual temperature (MAT) and lower mean annual precipitation (MAP) such as Metolius (1.71 kg m(-2); 15% of SOC) and Juniper (1.89 kg m(-2); 26% of SOC). In contrast, the highest PyC stocks were found under cooler and moister conditions at Cascade Head dominated by Douglas Fir (Pseudotsuga menziesii (Mirb.)) (5.66 kg m(-2); 16% of SOC) and Soapgrass Mountain (4.80 kg m(-2); 15% of SOC). PyC was only moderately related to non-PyC SOC, which comprises plant residues, their decomposition products and soil biota (r(2) = 0.61 and 0.44 for SOC with and without PyC, respectively), suggesting largely independent processes influencing production and disappearance. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Jauss, Verena; Lehmann, Johannes] Cornell Univ, Dept Crop & Soil Sci, Ithaca, NY 14853 USA.
[Johnson, Mark] Environm Protect Agcy, Western Ecol Div, Corvallis, OR 97333 USA.
[Krull, Evelyn] CSIRO Land & Water, Glen Osmond, SA 5064, Australia.
[Daub, Markus] Univ Stuttgart, Inst Anal Dynam & Modelling, D-70569 Stuttgart, Germany.
[Lehmann, Johannes] Cornell Univ, Atkinson Ctr Sustainable Future, Ithaca, NY 14853 USA.
RP Lehmann, J (reprint author), Cornell Univ, 909 Bradfield Hall, Ithaca, NY 14853 USA.
EM CL273@cornell.edu
FU NASA-USDA [2008-35615-18961]; Department of Crop and Soil Sciences at
Cornell University
FX Funding through NASA-USDA award No. 2008-35615-18961 and the Department
of Crop and Soil Sciences at Cornell University is gratefully
acknowledged. For help with fieldwork we would like to thank Sarah Hash
(Department of Crop and Soil Science, Oregon State University). Many
thanks to L.R. Spouncer and Jon Sanderman for help with MIR analyses and
data processing. We thank the anonymous referees for their constructive
comments.
NR 38
TC 5
Z9 5
U1 1
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0341-8162
EI 1872-6887
J9 CATENA
JI Catena
PD JAN
PY 2015
VL 124
BP 53
EP 59
DI 10.1016/j.catena.2014.09.001
PG 7
WC Geosciences, Multidisciplinary; Soil Science; Water Resources
SC Geology; Agriculture; Water Resources
GA AU3WJ
UT WOS:000345541200006
ER
PT J
AU Williams, WC
Copeland, C
Boykin, E
Quell, SJ
Lehmann, DM
AF Williams, W. C.
Copeland, C.
Boykin, E.
Quell, S. J.
Lehmann, D. M.
TI Development and utilization of an ex vivo bromodeoxyuridine local lymph
node assay protocol for assessing potential chemical sensitizers
SO JOURNAL OF APPLIED TOXICOLOGY
LA English
DT Article
DE Local lymph node assay; 5-bromo-2-deoxyuridine (BrdU); skin
sensitization; ex vivo; platinum
ID INTER-LABORATORY VALIDATION; ISOTOPIC END-POINT; ICCVAM EVALUATION;
MAXIMIZATION TEST; PLATINUM; POTENCY; ALLERGENS; PERFORMANCE; BRDU; LLNA
AB The murine local lymph node assay (LLNA) is widely used to identify chemicals that may cause allergic contact dermatitis. Exposure to a dermal sensitizer results in proliferation of local lymph node T cells, which has traditionally been measured by in vivo incorporation of [H-3]methyl thymidine. A more recent non-isotopic variation of the assay utilizes bromodeoxyuridine (BrdU) incorporation in vivo. To further improve the utility of this assay, we developed an ex vivo BrdU labeling procedure eliminating the need for in vivo injections. The results of this assay correctly identified a strong sensitizer (i.e., trimellitic anhydride) as well as weak/moderate sensitizers (i.e., eugenol, cinnamaldehyde and hexylcinnaminic aldehyde). As anticipated, neither non-sensitizers isopropanol and lactic acid nor the false negative chemical nickel II sulfate hexahydrate induced a positive threshold response in the assay. The results of this assay are in close agreement with those of the in vivo LLNA:BrdU-enzyme-linked immunosorbent assay labeling procedure. We also used the ex vivo BrdU LLNA procedure to evaluate ammonium hexachloroplatinate, ammonium tetrachloroplatinate and cis-diamminedichloroplatinum(II) and the assay correctly identified them as sensitizers based on the calculation of EC2 values. We conclude that this ex vivo BrdU labeling method offers predictive capacity comparable to previously established LLNA protocols while eliminating animal injections and the use of radioisotope. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
The murine local lymph node assay (LLNA) is widely used to identify chemicals that may cause allergic contact dermatitis. We developed an ex vivo BrdU-labeling procedure eliminating the need for in vivo injections. The ex vivo BrdU LLNA accurately predicted the sensitization potential of known sensitizers and non-sensitizers. This ex vivo BrdU labeling method offers predictive capacity comparable to previously established LLNA protocols while eliminating animal injections and the use of radioisotope.
C1 [Williams, W. C.; Copeland, C.; Boykin, E.; Lehmann, D. M.] US EPA, NHEERL, EPHD, Cardiopulm & Immunotoxicol Branch, Res Triangle Pk, NC 27711 USA.
RP Lehmann, DM (reprint author), US EPA, NHEERL, EPHD, Cardiopulm & Immunotoxicol Branch, Mail Drop B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM lehmann.david@epa.gov
NR 44
TC 2
Z9 2
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0260-437X
EI 1099-1263
J9 J APPL TOXICOL
JI J. Appl. Toxicol.
PD JAN
PY 2015
VL 35
IS 1
BP 29
EP 40
DI 10.1002/jat.2983
PG 12
WC Toxicology
SC Toxicology
GA AU4GD
UT WOS:000345567300004
PM 24532485
ER
PT J
AU Thai, SF
Wallace, KA
Jones, CP
Ren, HZ
Prasad, RY
Ward, WO
Kohan, MJ
Blackman, CF
AF Thai, Sheau-Fung
Wallace, Kathleen A.
Jones, Carlton P.
Ren, Hongzu
Prasad, Raju Y.
Ward, William O.
Kohan, Michael J.
Blackman, Carl F.
TI Signaling Pathways and MicroRNA Changes in Nano-TiO2 Treated Human Lung
Epithelial (BEAS-2B) Cells
SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
LA English
DT Article
DE Nanomaterial; Nano-Titanium Dioxide; mRNA Expression Profiling;
Signaling Pathways; MicroRNA Profiling; IPA MicroRNA Target Filter
Analysis
ID TITANIUM-DIOXIDE NANOPARTICLES; GROWTH-FACTOR; CANCER CELLS; MIR-17-92
CLUSTER; OXIDATIVE STRESS; THROMBOSPONDIN-1 EXPRESSION;
PROGNOSTIC-SIGNIFICANCE; CLINICAL-SIGNIFICANCE; PROGENITOR CELLS;
DNA-DAMAGE
AB The effect of titanium dioxide nanoparticles (nano-TiO2 Degussa p25) treatment of human lung epithelial cells (BEAS-2B) was examined by analyzing changes in messenger [mRNA] and microRNA [miRNA]. BEAS-2B cells were treated with 0, 3, 10, 30 or 100 mu g/ml nano-TiO2 for 1 day (for mRNA analysis) or 3 days (for miRNA analysis). Differentially expressed mRNA and miRNA were analyzed using Affymetrix microarrays and Affymetrix miRNA microarrays, respectively. Although, the tested doses were not cytotoxic, there were alterations in both mRNA and miRNA expression. The expression of mRNA/miRNA changes were examined in MetaCore (GeneGo) and IPA (Ingenuity Pathway Analysis) to delineate associated canonical/signaling pathways. Canonical/signaling pathways altered by nano-TiO2 treatments included: cell cycle regulation, apoptosis, calcium signaling, translation, NRF2 mediated oxidative response, IGF1 signaling, RAS signaling, PI3K/AKT signaling, cytoskeleton remodeling, cell adhesion, BMP signaling, and inflammatory response. Many of the genes in these pathways are known to be regulated by the miRNAs whose expressions were altered by the nano-TiO2 treatment. The miRNA 17-92 cluster and let-7 miRNA family that are involved in lung cancer formation were altered by nano-TiO2 treatment. The miR-17-92 cluster, an oncogenic microRNA cluster, is induced while the tumor suppressor microRNA, let-7 family, is suppressed. The changes of let-7/KRAS signaling pathway was observed in all the doses treated. The observed changes in miRNA expression introduces an additional mechanistic dimension that supports the significance of the observed mRNA expression changes, and demonstrated that the nano-TiO2 in vitro treatment in human lung cells can cause diverse but coordinated pathway alterations associated with changes in in vivo response to tumorigenes.
C1 [Thai, Sheau-Fung; Wallace, Kathleen A.; Jones, Carlton P.; Ren, Hongzu; Prasad, Raju Y.; Ward, William O.; Kohan, Michael J.; Blackman, Carl F.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Thai, SF (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,MD B105-3, Res Triangle Pk, NC 27711 USA.
OI Blackman, Carl/0000-0003-3267-5224
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 102
TC 3
Z9 3
U1 7
U2 38
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1533-4880
EI 1533-4899
J9 J NANOSCI NANOTECHNO
JI J. Nanosci. Nanotechnol.
PD JAN
PY 2015
VL 15
IS 1
BP 492
EP 503
DI 10.1166/jnn.2015.9202
PG 12
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AT6NA
UT WOS:000345054000089
PM 26328389
ER
PT J
AU Pauer, JJ
DePetro, PA
Anstead, AM
Lehrter, JC
AF Pauer, James J.
DePetro, Phillip A.
Anstead, Amy M.
Lehrter, John C.
TI Application of a one-dimensional model to explore the drivers and
lability of carbon in the northern Gulf of Mexico
SO ECOLOGICAL MODELLING
LA English
DT Article
DE Modeling; Nutrients; Hypoxia; Dissolved organic carbon; Light
limitation; Gulf of Mexico
ID DISSOLVED ORGANIC-MATTER; MISSISSIPPI RIVER PLUME; LOUISIANA
CONTINENTAL-SHELF; PHYTOPLANKTON PRODUCTION; COASTAL WATERS; FOOD-WEB;
HYPOXIA; NITROGEN; GROWTH; REGION
AB A one-dimensional water quality model, Gulf of Mexico Dissolved Oxygen Model (GoMDOM-1D), was developed to simulate phytoplankton, carbon, nitrogen and phosphorus in the northern Gulf of Mexico. The model was calibrated and corroborated against a comprehensive set of field observations and process measurements. Model results fit measured nutrients and phytoplankton concentrations well, but the model was unable to sustain dissolved organic carbon and water-column respiration at measured levels. The decline in modeled dissolved organic carbon (DOC) and respiration supports the notion that autochthonous production of DOC was insufficient to offset the respiratory demand from bacterial processes for the most of the Louisiana continental shelf. Transport of carbon from high production areas close to the Mississippi and Atchafalaya River plumes likely supplied a part of the respiratory demand of the water column. Modeling results showed that DOC in the study area on the Louisiana shelf was very labile with the highest lability during the month of June, and decreased lability in April. Primary production at the study sites was mainly nitrogen limited, although phosphorus limitation was found in the surface layers for the areas most impacted by the Mississippi River plume. The model also provided insights into the interplay between nutrients and light in regulating phytoplankton production, which is important when predicting the location and extent of hypoxia in the Gulf of Mexico. Published by Elsevier B.V.
C1 [Pauer, James J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div,Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[DePetro, Phillip A.] ICF Int, Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[Lehrter, John C.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Pauer, JJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div,Large Lakes Res Stn, 9311 Groh Rd, Grosse Ile, MI 48138 USA.
EM pauer.james@epa.gov
NR 60
TC 2
Z9 2
U1 2
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
EI 1872-7026
J9 ECOL MODEL
JI Ecol. Model.
PD DEC 24
PY 2014
VL 294
BP 59
EP 70
DI 10.1016/j.ecolmodel.2014.09.007
PG 12
WC Ecology
SC Environmental Sciences & Ecology
GA AU8BG
UT WOS:000345821100007
ER
PT J
AU McConnell, ER
Bell, SM
Cote, I
Wang, RL
Perkins, EJ
Garcia-Reyero, N
Gong, P
Burgoon, LD
AF McConnell, Emma R.
Bell, Shannon M.
Cote, Ila
Wang, Rong-Lin
Perkins, Edward J.
Garcia-Reyero, Natalia
Gong, Ping
Burgoon, Lyle D.
TI Systematic Omics Analysis Review (SOAR) Tool to Support Risk Assessment
SO PLOS ONE
LA English
DT Review
ID GENE-EXPRESSION; CIGARETTE-SMOKE; DIESEL EXHAUST; TRANSCRIPTOME; TCDD;
MICROARRAY; EXPOSURE; CELLS
AB Environmental health risk assessors are challenged to understand and incorporate new data streams as the field of toxicology continues to adopt new molecular and systems biology technologies. Systematic screening reviews can help risk assessors and assessment teams determine which studies to consider for inclusion in a human health assessment. A tool for systematic reviews should be standardized and transparent in order to consistently determine which studies meet minimum quality criteria prior to performing in-depth analyses of the data. The Systematic Omics Analysis Review (SOAR) tool is focused on assisting risk assessment support teams in performing systematic reviews of transcriptomic studies. SOAR is a spreadsheet tool of 35 objective questions developed by domain experts, focused on transcriptomic microarray studies, and including four main topics: test system, test substance, experimental design, and microarray data. The tool will be used as a guide to identify studies that meet basic published quality criteria, such as those defined by the Minimum Information About a Microarray Experiment standard and the Toxicological Data Reliability Assessment Tool. Seven scientists were recruited to test the tool by using it to independently rate 15 published manuscripts that study chemical exposures with microarrays. Using their feedback, questions were weighted based on importance of the information and a suitability cutoff was set for each of the four topic sections. The final validation resulted in 100% agreement between the users on four separate manuscripts, showing that the SOAR tool may be used to facilitate the standardized and transparent screening of microarray literature for environmental human health risk assessment.
C1 [McConnell, Emma R.; Bell, Shannon M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA.
[Cote, Ila] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Arlington, VA USA.
[Wang, Rong-Lin] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH USA.
[Perkins, Edward J.] US Army, Corps Engineers, Dept Army, Dept Def, Vicksburg, MS 39180 USA.
[Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem & Biochem, Jackson, MS USA.
[Gong, Ping] SpecPro Inc, Vicksburg, MS USA.
[Burgoon, Lyle D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Burgoon, LD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Burgoon.Lyle@epa.gov
OI Burgoon, Lyle/0000-0003-4977-5352
FU US EPA's Human Health Risk Assessment Program; SpecPro, Inc
FX This work was funded by the US EPA's Human Health Risk Assessment
Program. The funders had no role in study design, or data collection and
analysis. EPA management cleared the manuscript for publication, which
included helpful suggestions that improved the overall quality of the
manuscript, consistent with the US EPA Scientific Integrity Policy.
Co-author Ping Gong is employed by SpecPro, Inc. SpecPro, Inc provided
support in the form of salary for author PG, but did not have any
additional role in the study design, data collection and analysis,
decision to publish, or preparation of the manuscript. The specific role
of this author is articulated in the 'author contributions' section.
NR 29
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U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 22
PY 2014
VL 9
IS 12
AR UNSP e110379
DI 10.1371/journal.pone.0110379
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA3ZY
UT WOS:000348845100002
PM 25531884
ER
PT J
AU Brantley, HL
Thoma, ED
Squier, WC
Guven, BB
Lyon, D
AF Brantley, Halley L.
Thoma, Eben D.
Squier, William C.
Guven, Birnur B.
Lyon, David
TI Assessment of Methane Emissions from Oil and Gas Production Pads using
Mobile Measurements
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID NATURAL-GAS
AB A new mobile methane emissions inspection approach, Other Test Method (OTM) 33A, was used to quantify short-term emission rates from 210 oil and gas production pads during eight two-week field studies in Texas, Colorado, and Wyoming from 2010 to 2013. Emission rates were log-normally distributed with geometric means and 95% confidence intervals (CIs) of 0.33 (0.23, 0.48), 0.14 (0.11, 0.19), and 0.59 (0.47, 0.74) g/s in the Barnett, Denver-Julesburg, and Pinedale basins, respectively. This study focused on sites with emission rates above 0.01 g/s and included short-term (i.e., condensate tank flashing) and maintenance-related emissions. The results fell within the upper ranges of the distributions observed in recent onsite direct measurement studies. Considering data across all basins, a multivariate linear regression was used to assess the relationship of methane emissions to well age, gas production, and hydrocarbon liquids (oil or condensate) production. Methane emissions were positively correlated with gas production, but only approximately 10% of the variation in emission rates was explained by variation in production levels. The weak correlation between emission and production rates may indicate that maintenance-related stochastic variables and design of production and control equipment are factors determining emissions.
C1 [Brantley, Halley L.; Thoma, Eben D.; Squier, William C.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Guven, Birnur B.] Houston Adv Res Ctr, The Woodlands, TX 77381 USA.
[Lyon, David] Environm Def Fund, Austin, TX 78701 USA.
RP Thoma, ED (reprint author), US EPA, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM thoma.eben@epa.gov
FU U.S. EPA ORD's Air, Climate, and Energy (ACE); Regional Applied Research
Effort (RARE) programs; Fiona and Stan Druckenmiller, Heising-Simons
Foundation; Bill and Susan Oberndorf, Betsy and Sam Reeves, Robertson
Foundation; Alfred P. Sloan Foundation; TomKat Charitable Trust; Walton
Family Foundation
FX We thank Shahrooz Amin and Mark Modrak with ARCADIS, Inc., for field and
data analysis support for this project. We would like to thank EPA
colleagues Bill Mitchell, Adam Eisele, Mike Miller, Jason DeWees, Robin
Segall, and Ken Garing and his team for ongoing support in development
of OTM 33. Special thanks to Eric Crosson, Chris Rella, and Tracy Tsai
with Picarro for ongoing collaboration on mobile measurements. Primary
funding for this effort was provided by U.S. EPA ORD's Air, Climate, and
Energy (ACE) and Regional Applied Research Effort (RARE) programs.
Funding for the Environmental Defense Fund's methane research series,
including this work, is provided for by Fiona and Stan Druckenmiller,
Heising-Simons Foundation, Bill and Susan Oberndorf, Betsy and Sam
Reeves, Robertson Foundation, Alfred P. Sloan Foundation, TomKat
Charitable Trust, and the Walton Family Foundation. The views expressed
in this article are those of the authors and do not necessarily
represent the views or policies of the U.S. Environmental Protection
Agency.
NR 23
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U1 3
U2 21
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 16
PY 2014
VL 48
IS 24
BP 14508
EP 14515
DI 10.1021/es503070q
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AX1CO
UT WOS:000346686100054
PM 25375308
ER
PT J
AU George, IJ
Hays, MD
Snow, R
Faircloth, J
George, BJ
Long, T
Baldauf, RW
AF George, Ingrid J.
Hays, Michael D.
Snow, Richard
Faircloth, James
George, Barbara J.
Long, Thomas
Baldauf, Richard W.
TI Cold Temperature and Biodiesel Fuel Effects on Speciated Emissions of
Volatile Organic Compounds from Diesel Trucks
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID UNREGULATED EMISSIONS; POLLUTANT EMISSIONS; DRIVING CYCLES; HYDROCARBON
EMISSIONS; PASSENGER CAR; BLENDS; VEHICLE; CARBONYL; PARTICULATE;
GASOLINE
AB Speciated volatile organic compounds (VOCs) were measured in diesel exhaust from three heavy-duty trucks equipped with modern aftertreatment technologies. Emissions testing was conducted on a chassis dynamometer at two ambient temperatures (-7 and 22 degrees C) operating on two fuels (ultra low sulfur diesel and 20% soy biodiesel blend) over three driving cycles: cold start, warm start and heavy-duty urban dynamometer driving cycle. VOCs were measured separately for each drive cycle. Carbonyls such as formaldehyde and acetaldehyde dominated VOC emissions, making up similar to 72% of the sum of the speciated VOC emissions (Sigma VOCs) overall. Biodiesel use led to minor reductions in aromatics and variable changes in carbonyls. Cold temperature and cold start conditions caused dramatic enhancements in VOC emissions, mostly carbonyls, compared to the warmer temperature and other drive cycles, respectively. Different 2007+ aftertreatment technologies involving catalyst regeneration led to significant modifications of VOC emissions that were compound-specific and highly dependent on test conditions. A comparison of this work with emission rates from different diesel engines under various test conditions showed that these newer technologies resulted in lower emission rates of aromatic compounds. However, emissions of other toxic partial combustion products such as carbonyls were not reduced in the modern diesel vehicles tested.
C1 [George, Ingrid J.; Hays, Michael D.; Snow, Richard; Faircloth, James; Long, Thomas; Baldauf, Richard W.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[George, Barbara J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Hays, MD (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM hays.michael@epa.gov
RI Hays, Michael/E-6801-2013
OI Hays, Michael/0000-0002-4029-8660
NR 46
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U1 3
U2 31
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 16
PY 2014
VL 48
IS 24
BP 14782
EP 14789
DI 10.1021/es502949a
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AX1CO
UT WOS:000346686100086
PM 25393130
ER
PT J
AU Hubbell, B
Greenbaum, D
AF Hubbell, Bryan
Greenbaum, Daniel
TI Counterpoint: Moving From Potential-Outcomes Thinking to Doing-Changing
Research Planning to Enable Successful Health Outcomes Research
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE accountability; air pollution; health outcomes; regulations
AB The potential-outcomes framework is an appealing new approach that imposes a degree of formal conceptual modeling beyond traditional epidemiologic methods for assessing associations between air pollution and health. However, it introduces a number of additional factors to consider when selecting intervention and especially control conditions that call for forward-thinking research designs. We propose that researchers seeking to implement the potential-outcomes framework consider the use of prospective designs that provide more opportunities to establish well-defined intervention and control populations and determine causal relationships between air quality and health. In implementing these prospective research designs, collaboration between researchers and those who implement the interventions can improve the understanding of how a planned intervention actually occurs, thereby improving the characterization of emissions and air quality responses to the intervention. By looking ahead, epidemiologists can take advantage of upcoming regulatory interventions to design successful health outcomes research programs.
C1 [Hubbell, Bryan] US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Greenbaum, Daniel] Hlth Effects Inst, Boston, MA USA.
RP Hubbell, B (reprint author), US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, MD 504-02, Res Triangle Pk, NC 27711 USA.
EM hubbell.bryan@epa.gov
NR 8
TC 1
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U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD DEC 15
PY 2014
VL 180
IS 12
BP 1141
EP 1144
DI 10.1093/aje/kwu266
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AW6ZN
UT WOS:000346414300002
PM 25399413
ER
PT J
AU Goltz, MN
Huang, JQ
AF Goltz, Mark N.
Huang, Junqi
TI Reply to comment on "Validation of two innovative methods to measure
contaminant mass flux in groundwater" by Goltz et al. (2009)
SO JOURNAL OF CONTAMINANT HYDROLOGY
LA English
DT Editorial Material
DE Groundwater flow; Pump test; Modeling
C1 [Goltz, Mark N.] US Air Force, Inst Technol, ENV, Wright Patterson AFB, OH 45433 USA.
[Huang, Junqi] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74821 USA.
RP Goltz, MN (reprint author), US Air Force, Inst Technol, ENV, 2950 Hobson Way,Bldg 640, Wright Patterson AFB, OH 45433 USA.
EM mark.goltz@afit.edu; huang.junqi@epa.gov
NR 3
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-7722
EI 1873-6009
J9 J CONTAM HYDROL
JI J. Contam. Hydrol.
PD DEC 15
PY 2014
VL 171
BP 83
EP 84
DI 10.1016/j.jconhyd.2014.10.014
PG 2
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA AW6RO
UT WOS:000346396400009
PM 25453250
ER
PT J
AU Ziegler, AD
Sidle, RC
Phang, VXH
Wood, SH
Tantasirin, C
AF Ziegler, Alan D.
Sidle, R. C.
Phang, Valerie X. H.
Wood, Spencer H.
Tantasirin, Chatchai
TI Bedload transport in SE Asian streams-Uncertainties and implications for
reservoir management
SO GEOMORPHOLOGY
LA English
DT Review
DE Bedload-to-sediment ratio; Sediment yield; Road impacts; Mass wasting;
Dam building; Agriculture intensification
ID GRAVEL-BED STREAM; HELLEY-SMITH SAMPLERS; HORTON OVERLAND-FLOW; NORTHERN
THAILAND; SEDIMENT TRANSPORT; EXPERIMENTAL REMOVAL; PENINSULAR MALAYSIA;
MOUNTAIN STREAMS; SOUTHEAST-ASIA; LOAD TRANSPORT
AB This paper reviews the current state of knowledge regarding bedload transport in SE Asian streams and presents the results from a case study on bedload transport in a mountain stream in northern Thailand. Together, the review and new data help contextualize the paucity of work done in the region in the face of a rapid increase in development and reservoir building throughout SE Asia. Data from both the reviewed studies and the case study indicate that bedload transport in many SE Asian streams (e.g. catchment areas < 100 km(2)) is often much higher than is commonly assumed for tropical streams (i.e., about 10% of the total sediment load). Estimated annual bedload proportion was 18% of the total annual sediment load in the 74-km(2) Mae Sa Catchment in northern Thailand. Bedload transport rates ranged from 0.001 to 1.1 kg s(-1); and measured total suspended solid (TSS) rates ranged from 0.01 to 39 kg s(-1), equivalent to TSS concentrations of 20 to 14,000 mg I-1 (associated with flows ranging from 0.4 to 30 m(3) s(-1)). Event and annual loads of bedload and TSS were determined from rating curves based on automated measurements of discharge and turbidity (for TSS only). When taking uncertainty into account, the estimated range for the bedload proportion of total sediment load was 9-25% (equivalent to a yield of 81-279 Mg km(-2)y(-1)). The corresponding TSS yield estimate ranged from 649 to 1037 Mg km(-2); and the total sediment load is an estimated 730-1313 Mg km(-2)y(-1). The proportion of bedload was lower than that reported in some other Asia streams, probably due to the occurrence of extended periods with high TSS that dampened the bedload signal, which was sand-dominated during the low-energy events that were sampled. Nevertheless, the bedload rate was generally higher than for most SE Asian locations, likely due to the occurrence of several road-related landslides the previous year. Although we were not able to measure bedload transport for high energy flows (discharges > 4.5 m(3) s(-1)), we believe our upper estimates for bedload variables (25% of the total sediment load; and a yield of 279 Mg Km(-2) y(-1)) provide reasonable upper bounds. Finally, the bulk of bedload transport is episodic in nature, with a higher proportion moved during high energy tropical storms that occur late in the monsoon rainy season, as well as in response to both natural and anthropogenic landscape disturbances. The possibility that bedload proportion could exceed 20-40% for rivers and streams of various sizes reinforces the need for accurate estimates of both bedload and suspended solid loads prior to building dams in the region. Past examples of reservoir closure following rapid infilling possibly stem from underestimating sediment loads, particularly the bedload component, and failing to factor in the very high sediment loads associated with large storm events. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ziegler, Alan D.; Phang, Valerie X. H.] Natl Univ Singapore, Dept Geog, Singapore 117568, Singapore.
[Sidle, R. C.] US EPA, Ecosyst Res Div, Athens, GA USA.
[Wood, Spencer H.] Boise State Univ, Dept Geol Sci, Boise, ID 83725 USA.
[Tantasirin, Chatchai] Kasetsart Univ, Fac Forestry, Dept Conservat, Bangkok, Thailand.
RP Ziegler, AD (reprint author), Natl Univ Singapore, Dept Geog, 1 Arts Link, Singapore 117568, Singapore.
EM geoadz@nus.edu.sg
FU APN [ARCP2006-07NMY, ARCP2007-01CMY]; SARCS [95/01/CW-005]; NASA
[IDS/0365-0079]; NSF [EAR-0000546]
FX This work was supported in part by grants from the following agencies
APN (ARCP2006-07NMY, ARCP2007-01CMY), SARCS (95/01/CW-005), NASA
(IDS/0365-0079), NSF (EAR-0000546). Special thanks is given to our
colleagues Jefferson M Fox, Thomas W. Giambelluca, and Mike A Nullet,
who were instrumental in the establishment of monitoring network at Mae
Sa. We also thank R.J. Wasson for comments on the manuscript. This
document has been reviewed in accordance with the U.S. Environmental
Protection Agency policy and approved for publication. Mention of trade
names or commercial products does not constitute an endorsement or
recommendation for use.
NR 141
TC 6
Z9 6
U1 3
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-555X
EI 1872-695X
J9 GEOMORPHOLOGY
JI Geomorphology
PD DEC 15
PY 2014
VL 227
SI SI
BP 31
EP 48
DI 10.1016/j.geomorph.2014.01.015
PG 18
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA AR5KP
UT WOS:000343624000004
ER
PT J
AU Jagai, JS
Smith, GS
Schmid, JE
Wade, TJ
AF Jagai, Jyotsna S.
Smith, Genee S.
Schmid, Judith E.
Wade, Timothy J.
TI Trends in gastroenteritis-associated mortality in the United States,
1985-2005: variations by ICD-9 and ICD-10 codes
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Gastroenteritis; Mortality; Intestinal infections
ID INCREASING ANTIBIOTIC-RESISTANCE; CLOSTRIDIUM-DIFFICILE; DISEASES;
DEATHS; AGENTS; CARE
AB Background: Trends in gastroenteritis-associated mortality are changing over time with development of antibiotic resistant strains of certain pathogens, improved diagnostic methods, and changing healthcare. In 1999, ICD-10 coding was introduced for mortality records which can also affect trends. We assess trends in gastroenteritis-associated mortality and changes associated with coding.
Methods: Trends in gastroenteritis-associated mortality rates in the United States were examined using the National Center for Health Statistics Multiple Cause-of-Death Mortality databases for 1985-2005. All deaths with the underlying cause or any contributing cause included gastroenteritis were included. Cases were selected based on ICD9 (pre-1999) and ICD10 (1999-2005) codes and all analyses were stratified by ICD usage. Annual trends in age adjusted mortality rates were assessed using linear regression spline analysis. Relative risks and 95% confidence intervals (CIs) were calculated using Poisson regression adjusted for age group, sex, race, and region.
Results: There were a total of 190,674 deaths related to gastroenteritis in the U.S. from 1985-2005 with an average of 9,080 per year. During this time the percent of deaths related to gastroenteritis more than tripled, increasing from 0.25% to 0.80% of all deaths. Though the time periods varied in length, we demonstrate a significant increase in slope from a 0.0054% annual increase during the period 1985-1998, when ICD-9 coding was used, to a 0.0550% annual increase during 1999-2005, when ICD-10 coding was used. For both time periods, the oldest age group (75+ years) demonstrated the highest risk of death due to gastroenteritis. Additionally, males demonstrated higher risk than females and blacks were at higher risk than whites for death due to gastroenteritis.
Conclusions: This analysis demonstrates the public health burden of gastroenteritis-associated mortality in the United States and changes in trends due to change from ICD-9 to ICD-10 coding. The overall rate of gastroenteritis-associated mortality has more than tripled over the 21-year period from 1985 to 2005 and the primary burden of deaths due to gastroenteritis is in the elderly population.
C1 [Jagai, Jyotsna S.] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL 60625 USA.
[Smith, Genee S.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Schmid, Judith E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Cores Unit, Res Triangle Pk, NC 27711 USA.
[Jagai, Jyotsna S.; Wade, Timothy J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div,Epidemiol Branch, Res Triangle Pk, NC 27711 USA.
RP Jagai, JS (reprint author), Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL 60625 USA.
EM jjagai2@uic.edu
NR 25
TC 2
Z9 2
U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD DEC 10
PY 2014
VL 14
AR 211
DI 10.1186/s12876-014-0211-0
PG 8
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AX2AF
UT WOS:000346744800002
PM 25492520
ER
PT J
AU Baig, RBN
Varma, RS
AF Baig, R. B. Nasir
Varma, Rajender S.
TI Magnetic Silica-Supported Palladium Catalyst: Synthesis of Allyl Aryl
Ethers in Water
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID RECYCLABLE CATALYST; ORGANIC-SYNTHESIS; EFFICIENT; ALCOHOLS;
ETHERIFICATION; NANOPARTICLES; ARYLATION; COMPLEX
AB A simple and benign procedure for the synthesis of aryl allyl ethers has been developed using phenols, allyl acetates, and magnetically recyclable silica-supported palladium catalyst in water; the performance of the reaction in air and easy separation of the catalyst using an external magnet are sustainable attributes of the reaction.
C1 [Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@.epa.gov
FU Postgraduate Research Program at the National Risk Management Research
Laboratory
FX R.B.N.B. was supported by the Postgraduate Research Program at the
National Risk Management Research Laboratory, administered by the Oak
Ridge Institute for Science and Education, through an interagency
agreement between the U.S. Department of Energy and the U.S.
Environmental Protection Agency.
NR 38
TC 12
Z9 12
U1 3
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD DEC 10
PY 2014
VL 53
IS 49
BP 18625
EP 18629
DI 10.1021/ie501081q
PG 5
WC Engineering, Chemical
SC Engineering
GA AW5NR
UT WOS:000346322200004
ER
PT J
AU Wang, RL
Bencic, DC
Garcia-Reyero, N
Perkins, EJ
Villeneuve, DL
Ankley, GT
Biales, AD
AF Wang, Rong-Lin
Bencic, David C.
Garcia-Reyero, Natalia
Perkins, Edward J.
Villeneuve, Daniel L.
Ankley, Gerald T.
Biales, Adam D.
TI Natural Variation in Fish Transcriptomes: Comparative Analysis of the
Fathead Minnow (Pimephales promelas) and Zebrafish (Danio rerio)
SO PLOS ONE
LA English
DT Article
ID GENE-EXPRESSION SIGNATURES; NOISE; CONSEQUENCES; MECHANISMS; PLATFORMS;
MOLECULES; EVOLUTION; VARIANCE; PROFILES; PATTERNS
AB Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid the assessment and interpretation of subtle transcriptomic effects from treatment conditions of interest, better characterization and understanding are needed for natural variation in gene expression among fish individuals from lab cultures. Leveraging the transcriptomics data from a number of our toxicogenomics studies conducted over the years, we conducted a meta-analysis of nearly 600 microarrays generated from the ovary tissue of untreated, reproductively mature fathead minnow and zebrafish samples. As expected, there was considerable batch-to-batch transcriptomic variation; this "batch-effect'' appeared to differentially impact subsets of fish transcriptomes in a nonsystematic way. Temporally more closely spaced batches tended to share a greater transcriptomic similarity among one another. The overall level of within-batch variation was quite low in fish ovary tissue, making it a suitable system for studying chemical stressors with subtle biological effects. The observed differences in the within-batch variability of gene expression, at the levels of both individual genes and pathways, were probably both technical and biological. This suggests that biological interpretation and prioritization of genes and pathways targeted by experimental conditions should take into account both their intrinsic variability and the size of induced transcriptional changes. There was significant conservation of both the genomes and transcriptomes between fathead minnow and zebrafish. The high degree of conservation offers promising opportunities in not only studying fish molecular responses to environmental stressors by a comparative biology approach, but also effective sharing of a large amount of existing public transcriptomics data for developing toxicogenomics applications.
C1 [Wang, Rong-Lin; Bencic, David C.; Biales, Adam D.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Perkins, Edward J.] US Army Corps Engn, US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Wang, Rong-Lin; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA.
RP Wang, RL (reprint author), US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
EM wang.rong-lin@epa.gov
FU U.S. EPA; U.S. Army [BAA 11-4838]
FX Funding was provided by U.S. EPA and U.S. Army (grant BAA 11-4838). The
manuscript has been approved for publication by U.S. EPA and U.S. Army
Corps Chief of Engineers. The funders had no role in study design, data
collection and analysis, or preparation of the manuscript.
NR 56
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U1 3
U2 27
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 10
PY 2014
VL 9
IS 12
AR e114178
DI 10.1371/journal.pone.0114178
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AW9YP
UT WOS:000346611400034
PM 25493933
ER
PT J
AU Tufts, JAM
Meyer, KM
Calfee, MW
Lee, SD
AF Tufts, Jenia A. M.
Meyer, Kathryn M.
Calfee, Michael Worth
Lee, Sang Don
TI Composite Sampling of a Bacillus anthracis Surrogate with Cellulose
Sponge Surface Samplers from a Nonporous Surface
SO PLOS ONE
LA English
DT Article
ID FOODBORNE PATHOGENS; STAINLESS-STEEL; SPORES; SURVIVAL
AB A series of experiments was conducted to explore the utility of composite-based collection of surface samples for the detection of a Bacillus anthracis surrogate using cellulose sponge samplers on a nonporous stainless steel surface. Two composite-based collection approaches were evaluated over a surface area of 3716 cm(2) (four separate 929 cm(2) areas), larger than the 645 cm(2) prescribed by the standard Centers for Disease Control (CDC) and Prevention cellulose sponge sampling protocol for use on nonporous surfaces. The CDC method was also compared to a modified protocol where only one surface of the sponge sampler was used for each of the four areas composited. Differences in collection efficiency compared to positive controls and the potential for contaminant transfer for each protocol were assessed. The impact of the loss of wetting buffer from the sponge sampler onto additional surface areas sampled was evaluated. Statistical tests of the results using ANOVA indicate that the collection of composite samples using the modified sampling protocol is comparable to the collection of composite samples using the standard CDC protocol (p = 0.261). Most of the surface-bound spores are collected on the first sampling pass, suggesting that multiple passes with the sponge sampler over the same surface may be unnecessary. The effect of moisture loss from the sponge sampler on collection efficiency was not significant (p = 0.720) for both methods. Contaminant transfer occurs with both sampling protocols, but the magnitude of transfer is significantly greater when using the standard protocol than when the modified protocol is used (p<0.001). The results of this study suggest that composite surface sampling, by either method presented here, could successfully be used to increase the surface area sampled per sponge sampler, resulting in reduced sampling times in the field and decreased laboratory processing cost and turn-around times.
C1 [Tufts, Jenia A. M.; Meyer, Kathryn M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA.
[Tufts, Jenia A. M.; Meyer, Kathryn M.; Calfee, Michael Worth; Lee, Sang Don] US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Calfee, MW (reprint author), US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM calfee.worth@epa.gov
FU US EPA through an Interagency Agreement; US Department of Energy's ORISE
program; US EPA; ORISE
FX This work was funded by the US EPA through an Interagency Agreement with
the US Department of Energy's ORISE program. Authors MWC and SDL
received salary funds from the US EPA; JAT and KM received fellowship
stipends through ORISE.
NR 15
TC 3
Z9 3
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 3
PY 2014
VL 9
IS 12
AR e114082
DI 10.1371/journal.pone.0114082
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA7WS
UT WOS:000349128700068
PM 25470365
ER
PT J
AU Wang, HH
Ho, KT
Scheckel, KG
Wu, FC
Cantwell, MG
Katz, DR
Horowitz, DB
Boothman, WS
Burgess, RM
AF Wang, Huanhua
Ho, Kay T.
Scheckel, Kirk G.
Wu, Fengchang
Cantwell, Mark G.
Katz, David R.
Horowitz, Doranne Borsay
Boothman, Warren S.
Burgess, Robert M.
TI Toxicity, Bioaccumulation, and Biotransformation of Silver Nanoparticles
in Marine Organisms
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ACID-VOLATILE SULFIDE; ENVIRONMENTAL TRANSFORMATIONS; ENGINEERED
NANOMATERIALS; NEREIS-DIVERSICOLOR; SEDIMENTS; POLYCHAETE; IMPACT;
BIOAVAILABILITY; FATE; AGGREGATION
AB The toxicity, bioaccumulation, and biotransformation of citrate and polyvinylpyrrolidone (PVP) coated silver nanoparticles (NPs) (AgNP-citrate and AgNP-PVP) in marine organisms via marine sediment exposure was investigated. Results from 7-d sediment toxicity tests indicate that AgNP-citrate and AgNP-PVP did not exhibit toxicity to the amphipod (Ampelisca abdita) and mysid (Americamysis bahia) at <= 75 mg/kg dry wt. A 28-d bioaccumulation study showed that Ag was significantly accumulated in the marine polychaete Nereis virens (N. virens) in the AgNP-citrate, AgNP-PVP and a conventional salt (AgNO3) treatments. Synchrotron X-ray absorption spectroscopy (XAS) results showed the distribution of Ag species in marine sediments amended with AgNP-citrate, AgNP-PVP, and AgNO3 was AgCl (50-65%) > Ag2S (32-42%) > Ag metal (Ag-0) (3-11%). In N virens, AgCl (25-59%) and Ag2S (10-31%) generally decreased and, Ag metal (32-44%) increased, relative to the sediments. The patterns of speciation in the worm were different depending upon the coating of the AgNP and both types of AgNPs were different than the AgNO3 salt. These results show that the AgNP surface capping agents influenced Ag uptake, biotransformation, and/or excretion. To our knowledge, this is the first demonstration of the bioaccumulation and speciation of AgNPs in a marine organism (N. virens).
C1 [Wang, Huanhua; Ho, Kay T.; Cantwell, Mark G.; Katz, David R.; Horowitz, Doranne Borsay; Boothman, Warren S.; Burgess, Robert M.] US EPA, ORD, NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Wang, Huanhua; Wu, Fengchang] Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China.
[Scheckel, Kirk G.] US EPA, ORD, NRMRL, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA.
RP Ho, KT (reprint author), US EPA, ORD, NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
EM ho.kay@epa.gov; wufengchang@vip.skleg.cn
RI ID, MRCAT/G-7586-2011;
OI Scheckel, Kirk/0000-0001-9326-9241
FU U.S. EPA as a National Research Council postdoctoral research associate;
DOE Office of Science by Argonne National Laboratory
[DE-AC02-06CH11357]; US Department of Energy - Basic Energy Sciences;
NSERC; University of Washington; Canadian Light Source; Advanced Photon
Source; U.S. DOE [DE-AC02-06CH11357]
FX H. Wang was supported by the U.S. EPA as a National Research Council
postdoctoral research associate. The authors wish to thank Drs. Todd
Luxton, Walter Berry, and Shibin Li of the USEPA for their insightful
reviews of this manuscript. This research used resources of the Advanced
Photon Source, a U.S. Department of Energy (DOE) Office of Science User
Facility operated for the DOE Office of Science by Argonne National
Laboratory under Contract No. DE-AC02-06CH11357. Sector 20 facilities at
the Advanced Photon Source, and research at these facilities, are
supported by the US Department of Energy - Basic Energy Sciences, a
Major Resources Support grant from NSERC, the University of Washington,
the Canadian Light Source, and the Advanced Photon Source. Use of the
Advanced Photon Source, an Office of Science User Facility operated for
the U.S. Department of Energy Office of Science by Argonne National
Laboratory, was supported by the U.S. DOE under Contract No.
DE-AC02-06CH11357. The authors wish to thank Dr. Dale L. Brewe and Dr.
Robert Gordon for assistance in X-ray absorption spectroscopy and X-ray
fluorescence mapping at beamline 20-ID-B,C of PNC/XSD facilities. This
research has been subject to U.S. EPA peer review; however, it does not
necessarily reflect the views of the Agency. Mention of trade names of
commercial products and companies does not constitute endorsement or
recommendation for use. This is ORD # 007579.
NR 30
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U1 10
U2 94
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 2
PY 2014
VL 48
IS 23
BP 13711
EP 13717
DI 10.1021/es502976y
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AU7TN
UT WOS:000345803800019
PM 25369427
ER
PT J
AU Whitehouse, PJ
Sykes, K
George, DR
AF Whitehouse, Peter J.
Sykes, Kathy
George, Daniel R.
TI Ecological Change and Aging: A Need to Think Deeply and Act Quickly
SO INTERNATIONAL JOURNAL OF AGING & HUMAN DEVELOPMENT
LA English
DT Editorial Material
C1 [Whitehouse, Peter J.] Case Western Reserve Univ, Shaker Hts, OH 44122 USA.
[Sykes, Kathy] US EPA, Washington, DC 20460 USA.
[George, Daniel R.] Penn State Coll Med, Hershey, PA USA.
RP Whitehouse, PJ (reprint author), Case Western Reserve Univ, 2895 Carlton Rd, Shaker Hts, OH 44122 USA.
EM peter.whitehouse@case.edu
NR 4
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-4150
EI 1541-3535
J9 INT J AGING HUM DEV
JI Int. J. Aging Human Dev.
PD DEC
PY 2014
VL 80
IS 1
SI SI
BP 3
EP 9
DI 10.1177/0091415015591106
PG 7
WC Gerontology; Psychology, Developmental
SC Geriatrics & Gerontology; Psychology
GA CP2QR
UT WOS:000359722600001
PM 26215295
ER
PT J
AU Goh, V
Yap, HM
Gutierrez, RA
Ng, LC
Vesper, SS
AF Goh, V
Yap, H. M.
Gutierrez, R. A.
Ng, L. C.
Vesper, S. S.
TI DNA-Based Analyses of Molds in Singapore Public Buildings Results in a
Proposed Singapore Environmental Relative Moldiness Index
SO TROPICAL BIOMEDICINE
LA English
DT Article
ID ASPERGILLUS
AB Dust samples (n=75) were collected from shopping malls, hotels and libraries in Singapore and then analyzed using Mold Specific Quantitative Polymerase Chain Reaction (MSQPCR) for the 36 molds that make up the Environmental Relative Moldiness Index (ERMI). Most of these molds (23/36) occur at similar rates in Singapore and the United States. A Singapore Environmental Relative Moldiness Index (SERMI) is proposed which might be divided into low (<18), medium (18 to 28) and high (>28) mold burden categories but more samples will help to refine these categories.
C1 [Goh, V; Yap, H. M.; Gutierrez, R. A.; Ng, L. C.] Natl Environm Agcy, Environm Hlth Inst, Singapore 138667, Singapore.
[Vesper, S. S.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Ng, LC (reprint author), Natl Environm Agcy, Environm Hlth Inst, 11 Biopolis Way,06-05-08 Helios Block, Singapore 138667, Singapore.
EM ng_lee_ching@nea.gov.sg
FU Ministry of Environment and Water Resources (MEWR), Environmental
Innovation Funds [EIF 038]
FX This research was supported by the Ministry of Environment and Water
Resources (MEWR), Environmental Innovation Funds (EIF 038). We would
like to thank the shopping malls, libraries and hotels, which have
kindly agreed to participate in this study. The National Environment
Agency of Singapore would also like to express their heartfelt thanks to
Dr Stephen Vesper, Environmental Protection Agency, United States, for
his dedicated collaboration and guidance in the project.
NR 15
TC 1
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U1 2
U2 2
PU MALAYSIAN SOC PARASITOLOGY TROPICAL MEDICINE
PI KUALA LUMPUR
PA C/O INST MEDICAL REEARCH, JALAN PAHANG, KUALA LUMPUR, 50588, MALAYSIA
SN 0127-5720
J9 TROP BIOMED
JI Trop. Biomed.
PD DEC
PY 2014
VL 31
IS 4
BP 663
EP 669
PG 7
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA CB6CJ
UT WOS:000349714200010
PM 25776591
ER
PT J
AU Varma, RS
AF Varma, Rajender S.
TI Greener and Sustainable Chemistry
SO APPLIED SCIENCES-BASEL
LA English
DT Editorial Material
ID ASSISTED ORGANIC-SYNTHESIS; BENIGN REACTION MEDIA; SUPPORTED REAGENTS;
MICROWAVE; NANOPARTICLES; CATALYSTS
C1 US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA.
EM varma.rajender@epa.gov
NR 25
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U1 3
U2 27
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD DEC
PY 2014
VL 4
IS 4
BP 493
EP 497
DI 10.3390/app4040493
PG 5
WC Chemistry, Multidisciplinary; Materials Science, Multidisciplinary;
Physics, Applied
SC Chemistry; Materials Science; Physics
GA CA3ZP
UT WOS:000348844200002
ER
PT J
AU Villeneuve, DL
Crump, D
Garcia-Reyero, N
Hecker, M
Hutchinson, TH
LaLone, CA
Landesmann, B
Lettieri, T
Munn, S
Nepelska, M
Ottinger, MA
Vergauwen, L
Whelan, M
AF Villeneuve, Daniel L.
Crump, Doug
Garcia-Reyero, Natalia
Hecker, Markus
Hutchinson, Thomas H.
LaLone, Carlie A.
Landesmann, Brigitte
Lettieri, Teresa
Munn, Sharon
Nepelska, Malgorzata
Ottinger, Mary Ann
Vergauwen, Lucia
Whelan, Maurice
TI Adverse Outcome Pathway (AOP) Development I: Strategies and Principles
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE adverse outcome pathway; regulatory toxicology; predictive toxicology;
extrapolation; knowledgebase
ID DISRUPTING CHEMICALS; CONCEPTUAL-FRAMEWORK; RISK-ASSESSMENT; IPCS
FRAMEWORK; MODE; IDENTIFICATION; PRIORITIZATION; RELEVANCE; HUMANS
AB An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to improve regulatory decision-making through greater integration and more meaningful use of mechanistic data. However, for the scientific community to collectively develop a useful AOP knowledgebase that encompasses toxicological contexts of concern to human health and ecological risk assessment, it is critical that AOPs be developed in accordance with a consistent set of core principles. Based on the experiences and scientific discourse among a group of AOP practitioners, we propose a set of five fundamental principles that guide AOP development: (1) AOPs are not chemical specific; (2) AOPs are modular and composed of reusable components-notably key events (KEs) and key event relationships (KERs); (3) an individual AOP, composed of a single sequence of KEs and KERs, is a pragmatic unit of AOP development and evaluation; (4) networks composed of multiple AOPs that share common KEs and KERs are likely to be the functional unit of prediction for most real-world scenarios; and (5) AOPs are living documents that will evolve over time as new knowledge is generated. The goal of the present article was to introduce some strategies for AOP development and detail the rationale behind these 5 key principles. Consideration of these principles addresses many of the current uncertainties regarding the AOP framework and its application and is intended to foster greater consistency in AOP development.
C1 [Villeneuve, Daniel L.; LaLone, Carlie A.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA.
[Crump, Doug] Environm Canada, Ecotoxicol & Wildlife Hlth Div, Ottawa, ON K1A 0H3, Canada.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA.
[Hecker, Markus] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5B3, Canada.
[Hecker, Markus] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada.
[Hutchinson, Thomas H.] Univ Plymouth, Sch Biol Sci, Plymouth PL4 8AA, Devon, England.
[LaLone, Carlie A.] Univ Minnesota, Water Resources Ctr, St Paul, MN 55108 USA.
[Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Whelan, Maurice] Commiss European Communities, Joint Res Ctr, I-21027 Ispra, Italy.
[Ottinger, Mary Ann] Univ Houston, Dept Biol & Biochem, Houston, TX 77004 USA.
[Vergauwen, Lucia] Univ Antwerp, Dept Vet Sci, Zebrafishlab, B-2610 Antwerp, Belgium.
RP Villeneuve, DL (reprint author), US EPA, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM villeneuve.dan@epa.gov
OI Vergauwen, Lucia/0000-0002-6534-7473
NR 25
TC 47
Z9 49
U1 10
U2 74
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 312
EP 320
DI 10.1093/toxsci/kfu199
PG 9
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800001
PM 25466378
ER
PT J
AU Villeneuve, DL
Crump, D
Garcia-Reyero, N
Hecker, M
Hutchinson, TH
LaLone, CA
Landesmann, B
Lettieri, T
Munn, S
Nepelska, M
Ottinger, MA
Vergauwen, L
Whelan, M
AF Villeneuve, Daniel L.
Crump, Doug
Garcia-Reyero, Natalia
Hecker, Markus
Hutchinson, Thomas H.
LaLone, Carlie A.
Landesmann, Brigitte
Lettieri, Teresa
Munn, Sharon
Nepelska, Malgorzata
Ottinger, Mary Ann
Vergauwen, Lucia
Whelan, Maurice
TI Adverse Outcome Pathway Development II: Best Practices
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE adverse outcome pathway; regulatory toxicology; predictive toxicology;
extrapolation; knowledgebase
ID GROWTH PROMOTER 17-BETA-TRENBOLONE; ENDOCRINE DISRUPTION;
RISK-ASSESSMENT; IPCS FRAMEWORK; TOXICITY; CONSERVATION; TARGETS; MODE;
21ST-CENTURY; REACTIVITY
AB Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through development of internationally harmonized guidance and principles. The goal of this article was to outline the information content desired for formal AOP description and some rules of thumb and best practices intended to facilitate reuse and connectivity of elements of an AOP description in a knowledgebase and network context. For example, key events (KEs) are measurements of change in biological state that are indicative of progression of a perturbation toward a specified adverse outcome. Best practices for KE description suggest that each KE should be defined as an independent measurement made at a particular level of biological organization. The concept of "functional equivalence" can help guide both decisions about how many KEs to include in an AOP and the specificity with which they are defined. Likewise, in describing both KEs and evidence that supports a causal linkage or statistical association between them (ie, a key event relationship; KER), best practice is to build from and contribute to existing KE or KER descriptions in the AOP knowledgebase rather than creating redundant descriptions. The best practices proposed address many of the challenges and uncertainties related to AOP development and help promote a consistent and reliable, yet flexible approach.
C1 [Villeneuve, Daniel L.; LaLone, Carlie A.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA.
[Crump, Doug] Environm Canada, Ecotoxicol & Wildlife Hlth Div, Ottawa, ON K1A 0H3, Canada.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA.
[Hecker, Markus] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5B3, Canada.
[Hecker, Markus] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada.
[Hutchinson, Thomas H.] Univ Plymouth, Sch Biol Sci, Plymouth PL4 8AA, Devon, England.
[LaLone, Carlie A.] Univ Minnesota, Water Resources Ctr, St Paul, MN 55108 USA.
[Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Whelan, Maurice] Commiss European Communities, Joint Res Ctr, I-21027 Ispra, Italy.
[Ottinger, Mary Ann] Univ Houston, Dept Biol & Biochem, Houston, TX 77004 USA.
[Vergauwen, Lucia] Univ Antwerp, Dept Vet Sci, Zebrafishlab, B-2610 Antwerp, Belgium.
RP Villeneuve, DL (reprint author), US EPA, Mid Continent Ecol Div, 201 Congdon Blvd, Duluth, MN 55804 USA.
EM villeneuve.dan@epa.gov
OI Vergauwen, Lucia/0000-0002-6534-7473
NR 27
TC 38
Z9 39
U1 6
U2 43
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 321
EP 330
DI 10.1093/toxsci/kfu200
PG 10
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800002
PM 25466379
ER
PT J
AU Snow, SJ
McGee, J
Miller, DB
Bass, V
Schladweiler, MC
Thomas, RF
Krantz, T
King, C
Ledbetter, AD
Richards, J
Weinstein, JP
Conner, T
Willis, R
Linak, WP
Nash, D
Wood, CE
Elmore, SA
Morrison, JP
Johnson, CL
Gilmour, MI
Kodavanti, UP
AF Snow, Samantha J.
McGee, John
Miller, Desinia B.
Bass, Virginia
Schladweiler, Mette C.
Thomas, Ronald F.
Krantz, Todd
King, Charly
Ledbetter, Allen D.
Richards, Judy
Weinstein, Jason P.
Conner, Teri
Willis, Robert
Linak, William P.
Nash, David
Wood, Charles E.
Elmore, Susan A.
Morrison, James P.
Johnson, Crystal L.
Gilmour, Matthew Ian
Kodavanti, Urmila P.
TI Inhaled Diesel Emissions Generated with Cerium Oxide Nanoparticle Fuel
Additive Induce Adverse Pulmonary and Systemic Effects
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE diesel exhaust; cerium oxide; cardiopulmonary; nanoparticle
ID SPRAGUE-DAWLEY RATS; OXIDATIVE STRESS; EXHAUST INHALATION; INTRATRACHEAL
INSTILLATION; PARTICULATE MATTER; PERIPHERAL-BLOOD; IMMUNE-RESPONSES;
EXPOSURE; PARTICLES; CELLS
AB Diesel exhaust (DE) exposure induces adverse cardiopulmonary effects. Cerium oxide nanoparticles added to diesel fuel (DECe) increases fuel burning efficiency but leads to altered emission characteristics and potentially altered health effects. Here, we evaluated whether DECe results in greater adverse pulmonary effects compared with DE. Male Sprague Dawley rats were exposed to filtered air, DE, or DECe for 5 h/day for 2 days. N-acetyl glucosaminidase activity was increased in bronchial alveolar lavage fluid (BALF) of rats exposed to DECe but not DE. There were also marginal but insignificant increases in several other lung injury biomarkers in both exposure groups (DECe>DE for all). To further characterize DECe toxicity, rats in a second study were exposed to filtered air or DECe for 5 h/day for 2 days or 4 weeks. Tissue analysis indicated a concentration-and time-dependent accumulation of lung and liver cerium followed by a delayed clearance. The gas-phase and high concentration of DECe increased lung inflammation at the 2-day time point, indicating that gas-phase components, in addition to particles, contribute to pulmonary toxicity. This effect was reduced at 4 weeks except for a sustained increase in BALF gamma-glutamyl transferase activity. Histopathology and transmission electron microscopy revealed increased alveolar septa thickness due to edema and increased numbers of pigmented macrophages after DECe exposure. Collectively, these findings indicate that DECe induces more adverse pulmonary effects on a mass basis than DE. In addition, lung accumulation of cerium, systemic translocation to the liver, and delayed clearance are added concerns to existing health effects of DECe.
C1 [Snow, Samantha J.; Miller, Desinia B.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
[Snow, Samantha J.; McGee, John; Schladweiler, Mette C.; Thomas, Ronald F.; Krantz, Todd; King, Charly; Ledbetter, Allen D.; Richards, Judy; Gilmour, Matthew Ian; Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA.
[Bass, Virginia] Univ N Carolina, Gillings Sch Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Weinstein, Jason P.; Conner, Teri; Willis, Robert] US EPA, Environm Characterizat & Apportionment Branch, NERL, Res Triangle Pk, NC 27711 USA.
[Linak, William P.; Nash, David] US EPA, Air Pollut Prevent & Control Div, NRMRL, Res Triangle Pk, NC 27711 USA.
[Nash, David] Arcadis US Inc, Durham, NC 27713 USA.
[Wood, Charles E.] US EPA, Integrated Syst Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA.
[Elmore, Susan A.] Natl Inst Environm Hlth Sci, Natl Toxicol Program Div, Res Triangle Pk, NC 27711 USA.
[Morrison, James P.; Johnson, Crystal L.] Pathol Associates Inc, Charles River Labs, Durham, NC 27703 USA.
RP Snow, SJ (reprint author), US EPA, Environm Publ Hlth Div, NHEERL, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM snow.samantha@epa.gov
OI Bass, Virginia/0000-0001-6219-2448; Snow, Samantha/0000-0003-1812-8582
FU U.S. Environmental Protection Agency/University of North Carolina
Toxicology [CR835152010]; U.S. Environmental Protection Agency Senior
Environmental Employment Program; Division of the National Toxicology
Program of the National Institutes of Health
FX This work was supported by the U.S. Environmental Protection
Agency/University of North Carolina Toxicology Training Agreement
CR835152010 to S.J.S.; U.S. Environmental Protection Agency Senior
Environmental Employment Program to R.F.T.; and the Division of the
National Toxicology Program of the National Institutes of Health.
NR 66
TC 7
Z9 8
U1 2
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 403
EP 417
DI 10.1093/toxsci/kfu187
PG 15
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800010
PM 25239632
ER
PT J
AU Dishaw, LV
Hunter, DL
Padnos, B
Padilla, S
Stapleton, HM
AF Dishaw, Laura V.
Hunter, Deborah L.
Padnos, Beth
Padilla, Stephanie
Stapleton, Heather M.
TI Developmental Exposure to Organophosphate Flame Retardants Elicits Overt
Toxicity and Alters Behavior in Early Life Stage Zebrafish (Danio rerio)
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE flame retardant; organophosphate; TDCPP; zebrafish; development;
neurotoxicity
ID LARVAL ZEBRAFISH; HORMONE-LEVELS; HOUSE-DUST; IN-VIVO; TDCPP;
CHLORPYRIFOS; NEUROTOXICITY; METABOLITES; PHOSPHATE;
ACETYLCHOLINESTERASE
AB Organophosphate flame retardants (OPFRs) are common replacements for the phased-out polybrominated diphenyl ethers (PBDEs) and have been detected at high concentrations in environmental samples. OPFRs are structurally similar to organophosphate pesticides and may adversely affect the developing nervous system. This study evaluated the overt toxicity, uptake, and neurobehavioral effects of tris (1,3-dichloro-2-propyl) phosphate (TDCPP), tris (2-chloroethyl) phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCPP), and tris (2,3-dibromopropyl) phosphate (TDBPP) in early life stage zebrafish. Chlorpyrifos was used as a positive control. For overt toxicity and neurobehavioral assessments, zebrafish were exposed from 0 to 5 days postfertilization (dpf). Hatching, death, or malformations were evaluated daily. Teratogenic effects were scored by visual examination on 6 dpf. To evaluate uptake and metabolism, zebrafish were exposed to 1 mu M of each organophosphate (OP) flame retardant and collected on 1 and 5 dpf to monitor accumulation. Larval swimming activity was measured in 6 dpf larvae to evaluate neurobehavioral effects of exposures below the acute toxicity threshold. TDBPP elicited the greatest toxicity at >1 mu M. TDCPP and chlorpyrifos were overtly toxic at concentrations >= 10 mu M, TCEP, and TCPP were not overtly toxic at the doses tested. Tissue concentrations increased with increasing hydrophobicity of the parent chemical after 24h exposures. TDCPP and TDBPP and their respective metabolites were detected in embryos on 5 dpf. For all chemicals tested, developmental exposures that were not overtly toxic significantly altered larval swimming activity. These data indicate that OPFRs adversely affect development of early life stage zebrafish.
C1 [Dishaw, Laura V.; Stapleton, Heather M.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA.
[Hunter, Deborah L.; Padnos, Beth; Padilla, Stephanie] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Stapleton, HM (reprint author), Duke Univ, Nicholas Sch Environm, Box 90328,LSRC A220, Durham, NC 27708 USA.
EM heather.stapleton@duke.edu
FU National Institute of Environmental Health Sciences [R01 ES016099]; US
Environmental Protection Agency STAR Fellowship [FP 91728801]
FX This study was supported by the National Institute of Environmental
Health Sciences [R01 ES016099] and the US Environmental Protection
Agency STAR Fellowship [FP 91728801].
NR 43
TC 24
Z9 25
U1 17
U2 127
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2014
VL 142
IS 2
BP 445
EP 454
DI 10.1093/toxsci/kfu194
PG 10
WC Toxicology
SC Toxicology
GA AY5MZ
UT WOS:000347617800014
PM 25239634
ER
PT J
AU Wu, WD
Muller, R
Berhane, K
Fruin, S
Liu, FF
Jaspers, I
Diaz-Sanchez, D
Peden, DB
McConnell, R
AF Wu, Weidong
Muller, Robin
Berhane, Kiros
Fruin, Scott
Liu, Feifei
Jaspers, Ilona
Diaz-Sanchez, David
Peden, David B.
McConnell, Rob
TI Inflammatory Response of Monocytes to Ambient Particles Varies by
Highway Proximity
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE traffic-related air pollution; oxidative stress; inflammation; exposure
assessment; epidemiology
ID AIRBORNE PARTICULATE MATTER; OXIDATIVE STRESS; AIR-POLLUTION;
CHEMICAL-COMPOSITION; HOSPITAL ADMISSIONS; EPITHELIAL-CELLS; DAILY
MORTALITY; DIFFERENT SITES; LUNG INJURY; UTAH VALLEY
AB Epidemiological studies have demonstrated associations of chronic respiratory disease with near-roadway pollutant exposure, effects that were independent of those of regional air pollutants. However, there has been limited study of the potential mechanisms for near roadway effects. Therefore, we examined the in vitro effect of respirable particulate matter (PM) collected adjacent to a major Los Angeles freeway and at an urban background location. PM was collected on filters during two consecutive 15-day periods. Oxidative stress and inflammatory response (intracellular reactive oxygen species [ROS], IL-1 beta, IL-6, IL-8, and TNF-alpha) to PM aqueous extract was assessed in THP-1 cells, a model for evaluating monocyte/macrophage lineage cell responses. The near-roadway PM induced statistically significantly higher levels of IL-6, IL-8, and TNF-alpha (P < 0.01) and a near significant increase in IL-1 beta (P = 0.06) but did not induce ROS activity (P = 0.17). The contrast between urban background and near-roadway PM-induced inflammatory cytokines was similar in magnitude to that corresponding to temporal differences between the two collection periods. PM-induced proinflammatory protein expression was attenuated by antioxidant pretreatment, and PM stimulation enhanced the activity of protein kinases, including extracellular signal-regulated kinase and c-Jun N-terminal kinase. Pretreatment of THP-1 cells with kinase inhibitors reduced PM-induced proinflammatory mediator expression. The proinflammatory response was also reduced by pretreatment with polymyxin B, suggesting a role for endotoxin. However, the patterns of PM-induced protein kinase response and the attenuation of inflammatory responses by antioxidant or polymyxin B pretreatment did not vary between near-roadway and urban background locations. We conclude that near-roadway PM produced greater inflammatory response than urban background PM, a finding consistent with emerging epidemiologic findings, but these differences were not explained by PM endotoxin content or by MAPK pathways. Nevertheless, THP-1 cells may be a model for the development of biologically relevant metrics of long-term spatial variation in exposure for study of chronic disease.
C1 [Wu, Weidong] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Henan Province, Peoples R China.
[Wu, Weidong; Muller, Robin; Jaspers, Ilona; Peden, David B.] Univ N Carolina, Sch Med, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA.
[Berhane, Kiros; Fruin, Scott; Liu, Feifei; McConnell, Rob] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA.
[Diaz-Sanchez, David] US EPA, Off Res & Dev, Washington, DC 20460 USA.
RP McConnell, R (reprint author), Univ So Calif, Keck Sch Med, 2001 N Soto St, Los Angeles, CA 90089 USA.
EM rmcconne@usc.edu
FU National Institutes of Health [P30ES007048, P01ES011627, P01ES022845,
R01 ES016535, T32 ES007126, K25ES019224, U19AI077437]; Environmental
Protection Agency [CR 83346301, RD83544101, R831845]; Hastings
Foundation
FX This work was supported by National Institutes of Health grants
P30ES007048, P01ES011627, P01ES022845, R01 ES016535, T32 ES007126,
K25ES019224, and U19AI077437; by Environmental Protection Agency grants
CR 83346301, RD83544101, and R831845; and by the Hastings Foundation.
NR 43
TC 8
Z9 8
U1 1
U2 13
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD DEC
PY 2014
VL 51
IS 6
BP 802
EP 809
DI 10.1165/rcmb.2013-0265OC
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA AY2KS
UT WOS:000347419700009
PM 24895888
ER
PT J
AU Martinu, T
Gowdy, KM
Nugent, JL
Sun, J
Kinnier, CV
Nelson, ME
Lyes, MA
Kelly, FL
Foster, WM
Gunn, MD
Palmer, SM
AF Martinu, Tereza
Gowdy, Kymberly M.
Nugent, Julia L.
Sun, Jesse
Kinnier, Christine V.
Nelson, Margaret E.
Lyes, Matthew A.
Kelly, Francine L.
Foster, W. Michael
Gunn, Michael D.
Palmer, Scott M.
TI Role of C-C Motif Ligand 2 and C-C Motif Receptor 2 in Murine Pulmonary
Graft-versus-Host Disease after Lipopolysaccharide Inhalations
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE graft-versus-host disease; lipopolysaccharide; dendritic cells; C-C
motif ligand 2; C-C motif receptor 2
ID CHEMOATTRACTANT PROTEIN-1 MCP-1; IDIOPATHIC PNEUMONIA SYNDROME;
STEM-CELL TRANSPLANTATION; INNATE IMMUNE ACTIVATION; DENDRITIC CELLS;
LUNG INJURY; AIRWAY HYPERRESPONSIVENESS; INHALED LIPOPOLYSACCHARIDE;
CHEMOKINE RECEPTOR-2; CCR2(-/-) MICE
AB Environmental exposures are a potential trigger of chronic pulmonary graft-versus-host disease (pGVHD) after successful recovery from hematopoietic cell transplant (HCT). We hypothesized that inhalations of LPS, a prototypic environmental stimulus, trigger pGVHD via increased pulmonary recruitment of donor-derived antigen-presenting cells (APCs) through the C-C motif ligand 2 (CCL2)-C-C motif receptor 2 (CCR2) chemokine axis. B10.BR(H2(k)) and C57BL/6(H2(b)) mice underwent allogeneic (Allo) or syngeneic (Syn) HCT with wild-type (WT) C57BL/6, CCL2(-/-), or CCR2(-/-) donors. After 4 weeks, recipient mice received daily inhaled LPS for 5 days and were killed at multiple time points. Allo mice exposed to repeated inhaled LPS developed prominent lymphocytic bronchiolitis, similar to human pGVHD. The increase in pulmonary T cells in Allo mice after LPS exposures was accompanied by increased CCL2, CCR2, and Type-1 T-helper cytokines as well as by monocytes and monocytederived dendritic cells (moDCs) compared with Syn and nontransplanted controls. Using CCL2(-/-) donors leads to a significant decrease in lungDCs but to only mildly reduced CD4 T cells. Using CCR2(-/-) donors significantly reduces lung DCs and moDCs but does not change T cells. CCL2 or CCR2 deficiency does not alter pGVHD pathology but increases airway hyperreactivity and IL-5 or IL-13 cytokines. Our results show that hematopoietic donor- derived CCL2 and CCR2 regulate recruitment of APCs to the Allo lung after LPS exposure. Although they do not alter pathologic pGVHD, their absence is associated with increased airway hyperreactivity and IL-5 and IL-13 cytokines. These results suggest that the APC changes that result from CCL2-CCR2 blockade may have unexpected effects on T cell differentiation and physiologic outcomes in HCT.
C1 [Martinu, Tereza; Nelson, Margaret E.; Lyes, Matthew A.; Kelly, Francine L.; Foster, W. Michael; Gunn, Michael D.; Palmer, Scott M.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Palmer, Scott M.] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27710 USA.
[Gowdy, Kymberly M.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Nugent, Julia L.; Sun, Jesse] Univ N Carolina, Sch Med, Chapel Hill, NC USA.
[Kinnier, Christine V.] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA.
RP Martinu, T (reprint author), Duke Univ, Med Ctr, DUMC Box 3221, Durham, NC 27710 USA.
EM tereza.martinu@duke.edu
FU National Institutes of Health [S10RR019145]
FX The authors thank Mr. Robert F. Beasley for help with lung DC isolation.
Flow cytometric sorting was performed in the Duke Human Vaccine
Institute Research Flow Cytometry Shared Resource Facility (Durham, NC)
supported by National Institutes of Health grant S10RR019145.
NR 36
TC 1
Z9 1
U1 0
U2 3
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD DEC
PY 2014
VL 51
IS 6
BP 810
EP 821
DI 10.1165/rcmb.2013-0451OC
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA AY2KS
UT WOS:000347419700010
PM 24921973
ER
PT J
AU Filer, D
Patisaul, HB
Schug, T
Reif, D
Thayer, K
AF Filer, Dayne
Patisaul, Heather B.
Schug, Thaddeus
Reif, David
Thayer, Kristina
TI Test driving ToxCast: endocrine profiling for 1858 chemicals included in
phase II
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Article
ID PROTECTION
AB Identifying chemicals, beyond those already implicated, to test for potential endocrine disruption is a challenge and high throughput approaches have emerged as a potential tool for this type of screening. This review focused the Environmental Protection Agency's (EPA) ToxCast (TM) high throughput in vitro screening (HTS) program. Utility for identifying compounds was assessed and reviewed by using it to run the recently expanded chemical library (from 309 compounds to 1858) through the ToxPi (TM) prioritization scheme for endocrine disruption. The analysis included metabolic and neuroendocrine targets. This investigative approach simultaneously assessed the utility of ToxCast, and helped identify novel chemicals which may have endocrine activity. Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
C1 [Filer, Dayne] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[Patisaul, Heather B.] N Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, Raleigh, NC 27695 USA.
[Schug, Thaddeus] NIEHS, Div Extramural Res, NIH, Dept Hlth & Human Serv, Morrisville, NC 27560 USA.
[Reif, David] N Carolina State Univ, Bioinformat Res Ctr, Dept Biol Sci, Raleigh, NC 27695 USA.
[Thayer, Kristina] NIEHS, Off Hlth Assessment & Translat, Div Natl Toxicol Program, NIH,Dept Hlth & Human Serv, Morrisville, NC 27560 USA.
RP Thayer, K (reprint author), NIEHS, Off Hlth Assessment & Translat, Div Natl Toxicol Program, NIH,Dept Hlth & Human Serv, 530 Davis Dr,Room 2150 Mail Drop K2-04, Morrisville, NC 27560 USA.
EM thayer@niehs.nih.gov
OI Reif, David/0000-0001-7815-6767
FU Intramural NIH HHS [ZIA ES103226-01]
NR 16
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Z9 13
U1 2
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2014
VL 19
BP 145
EP 152
DI 10.1016/j.coph.2014.09.021
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AY3UO
UT WOS:000347508000023
PM 25460227
ER
PT J
AU Zhang, Q
Bhattacharya, S
Conolly, RB
Clewell, HJ
Kaminski, NE
Andersen, ME
AF Zhang, Qiang
Bhattacharya, Sudin
Conolly, Rory B.
Clewell, Harvey J., III
Kaminski, Norbert E.
Andersen, Melvin E.
TI Molecular Signaling Network Motifs Provide a Mechanistic Basis for
Cellular Threshold Responses
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID ENVIRONMENTAL CONTAMINANT 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN;
TRANSCRIPTION FACTOR NFAT1; ROBUST PERFECT ADAPTATION; INTEGRAL
FEEDBACK-CONTROL; LOW-DOSE EXTRAPOLATION; HEAT-SHOCK FACTOR;
RISK-ASSESSMENT; GENE-EXPRESSION; CHEMICAL CARCINOGENESIS; BIOCHEMICAL
SYSTEMS
AB Background: Increasingly, there is a move toward using in vitro toxicity testing to assess human health risk due to chemical exposure. As with in vivo toxicity testing, an important question for in vitro results is whether there are thresholds for adverse cellular responses. Empirical evaluations may show consistency with thresholds, but the main evidence has to come from mechanistic considerations.
Objectives: Cellular response behaviors depend on the molecular pathway and circuitry in the cell and the manner in which chemicals perturb these circuits. Understanding circuit structures that are inherently capable of resisting small perturbations and producing threshold responses is an important step towards mechanistically interpreting in vitro testing data.
Methods: Here we have examined dose-response characteristics for several biochemical network motifs. These network motifs are basic building blocks of molecular circuits underpinning a variety of cellular functions, including adaptation, homeostasis, proliferation, differentiation, and apoptosis. For each motif, we present biological examples and models to illustrate how thresholds arise from specific network structures.
Discussion and Conclusion: Integral feedback, feedforward, and transcritical bifurcation motifs can generate thresholds. Other motifs (e. g., proportional feedback and ultrasensitivity) produce responses where the slope in the low-dose region is small and stays close to the baseline. Feedforward control may lead to nonmonotonic or hormetic responses. We conclude that network motifs provide a basis for understanding thresholds for cellular responses. Computational pathway modeling of these motifs and their combinations occurring in molecular signaling networks will be a key element in new risk assessment approaches based on in vitro cellular assays.
C1 [Zhang, Qiang; Bhattacharya, Sudin; Clewell, Harvey J., III; Andersen, Melvin E.] Hamner Inst Hlth Sci, Inst Chem Safety Sci, Res Triangle Pk, NC 27709 USA.
[Conolly, Rory B.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Durham, NC USA.
[Kaminski, Norbert E.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
[Kaminski, Norbert E.] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA.
RP Zhang, Q (reprint author), Hamner Inst Hlth Sci, Ctr Dose Response Modeling, Inst Chem Safety Sci, 6 Davis Dr, Res Triangle Pk, NC 27709 USA.
EM qzhang@thehamner.org
FU National Institute of Environmental Health Sciences (NIEHS) [P42ES04911]
FX The National Institute of Environmental Health Sciences (NIEHS)
Superfund Research Program at Michigan State University (P42ES04911)
provided support for the Computational Core at The Hamner Institutes to
model research results from the program itself and also to generate
better mechanistic understanding of the behavior of basic network motifs
involved in generating and maintaining biological functions in cellular
systems. [Short courses of computational systems biology pathway
modeling have been developed by the Computational Core; course
materials, including lectures, modeling tutorials, and computational
models are available online (http://www. thehamner.
org/about-the-hamner/education-training/ dose-response-modeling).] Key
sponsors of computational systems biology pathway modeling of the Hamner
programs over the past decade include the ExxonMobil Foundation, Dow
Chemical Foundation, Unilever, Dow Corning Chemical Corporation, and the
American Chemistry Council Long-Range Research Initiative.
NR 104
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Z9 18
U1 3
U2 28
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD DEC
PY 2014
VL 122
IS 12
BP 1261
EP 1270
DI 10.1289/ehp.1408244
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AY1YC
UT WOS:000347384600011
PM 25117432
ER
PT J
AU Quiros-Alcala, L
Mehta, S
Eskenazi, B
AF Quiros-Alcala, Lesliam
Mehta, Suril
Eskenazi, Brenda
TI Pyrethroid Pesticide Exposure and Parental Report of Learning Disability
and Attention Deficit/Hyperactivity Disorder in US Children: NHANES
1999-2002
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID URINARY METABOLITES; PERMETHRIN EXPOSURE; INSECTICIDES; RATS;
DELTAMETHRIN; MICE; NEUROTOXICITY; CYPERMETHRIN; ASSOCIATION; POPULATION
AB BACKGROUND: Use of pyrethroid insecticides has increased dramatically over the past decade; however, data on their potential health effects, particularly on children, are limited.
OBJECTIVE: We examined the cross-sectional association between postnatal pyrethroid exposure and parental report of learning disability (LD) and attention deficit/hyperactivity disorder (ADHD) in children 6-15 years of age.
METHODS: Using logistic regression, we estimated associations of urinary metabolites of pyrethroid insecticides with parent-reported LD, ADHD, and both LD and ADHD in 1,659-1,680 children participating in the National Health and Nutrition Examination Survey (1999-2002).
RESULTS: The prevalence rates of parent-reported LD, ADHD, and both LD and ADHD were 12.7%, 10.0%, and 5.4%, respectively. Metabolite detection frequencies for 3-PBA [3-phenoxybenzoic acid], cis-DCCA [cis-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid], and trans-DCCA [trans-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid] were 77.1%, 35.6%, and 33.9%, respectively. The geometric mean 3-PBA concentration was 0.32 mu g/L (median = 0.31 mu g/L; interquartile rage = 0.10-0.89 mu g/L). cis- and trans-DCCA 75th-percentile concentrations were 0.21 mu g/L and 0.68 mu g/L, respectively. Log(10)-transformed 3-PBA concentrations were associated with adjusted odds ratios (ORs) of 1.18 (95% CI: 0.92, 1.51) for parent-reported LD, 1.16 (95% CI: 0.85, 1.58) for ADHD, and 1.45 (95% CI: 0.92, 2.27) for both LD and ADHD. Adjusted ORs remained nonsignificant and decreased after controlling for creatinine and other environmental chemicals previously linked to altered neurodevelopment. Similarly, no significant associations were observed for cis-and trans-DCCA.
CONCLUSIONS: Postnatal pyrethroid exposure was not associated with parental report of LD and/or ADHD. Given the widespread and increasing use of pyrethroids, future research should evaluate exposures at current levels, particularly during critical windows of brain development.
C1 [Quiros-Alcala, Lesliam; Eskenazi, Brenda] Univ Calif Berkeley, Sch Publ Hlth, CERCH, Berkeley, CA 94706 USA.
[Mehta, Suril] US EPA, Offc Childrens Hlth Protect, Washington, DC 20460 USA.
RP Quiros-Alcala, L (reprint author), Univ Calif Berkeley, Sch Publ Hlth, CERCH, 1995 Univ Ave,Suite 265, Berkeley, CA 94706 USA.
EM lquiros@berkeley.edu
RI Quiros-Alcala, Lesliam /Q-4928-2016
OI Quiros-Alcala, Lesliam /0000-0002-6600-7227
FU Science Innovation Fund from the Passport Foundation; National Institute
of Environmental Health Sciences [PO1ES009605]; U.S. EPA [RD83451301]
FX The National Health and Nutrition Examination Survey was conducted by
the National Center for Health Statistics, and the data analysis for
this research was funded by a Science Innovation Fund from the Passport
Foundation. Additional funding was received from the National Institute
of Environmental Health Sciences (PO1ES009605) and the U.S. EPA
(RD83451301).
NR 51
TC 12
Z9 12
U1 7
U2 25
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD DEC
PY 2014
VL 122
IS 12
BP 1336
EP 1342
DI 10.1289/ehp.1308031
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AY1YC
UT WOS:000347384600023
PM 25192380
ER
PT J
AU Rossmann, R
Pfeiffer, EL
Filkins, JC
AF Rossmann, Ronald
Pfeiffer, Erika L.
Filkins, John C.
TI Lake Michigan sediment lead storage and history of loads
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Lake Michigan; Lead; Loads; Storage
ID GREEN BAY; MERCURY; DEPOSITION; RECORD; FLUXES; POLLUTION; METALS;
CORES; CADMIUM; POLLUTANTS
AB Dated sediment box cores collected in 1994-1996 from 52 locations in Lake Michigan were analyzed to assess storage, trends, and loading history of lead. The results of this study provide information of historic lead loads to the lake for a time period (pre-1960) for which no reliable lead measurements exist. The information can be utilized by those wishing to model lead and to access lead loading trends. Anthropogenic lead storage in the lake's sediments totaled 143,000 t as of 1994. Storage of acid-extractable total (anthropogenic + background) lead totaled 171,000 t between 1850 and 1994. The date of 1850 is the time at which lead loads increased above background loads (219 t/y) to the lake. Anthropogenic loads peaked between 1959 and 1962 at 2440 t/y and were 1170 t/y between 1994 and 1995, illustrating that at the time of collection in 1994, loads were decreasing from previous highs. The load in 1994 to 1995 was equivalent to the load during the time frame of 1922 to 1925. Largest lead loads were to southeastern Lake Michigan in a region downwind of Chicago, illustrating the impact of large populated areas utilizing coal and gasoline on lead loads to the lake. Loading trends were impacted by coal and gasoline consumption, increased industrial activity during World War II, the Clean Air Act of 1970, and the phase-out of leaded gasoline. (C) 2014 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved.
C1 [Rossmann, Ronald] Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[Pfeiffer, Erika L.] Z Tech Corp, ICF Co, Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[Filkins, John C.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Large Lakes, Midcontinent Ecol Div,Large Lakes & Rivers Foreca, Grosse Ile, MI 48138 USA.
RP Rossmann, R (reprint author), Large Lakes Res Stn, 9311 Groh Rd, Grosse Ile, MI 48138 USA.
EM ronaldrossmann@hotmail.com
NR 63
TC 0
Z9 0
U1 1
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD DEC
PY 2014
VL 40
IS 4
BP 851
EP 858
DI 10.1016/j.jglr.2014.08.008
PG 8
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AY0FX
UT WOS:000347274000004
ER
PT J
AU Chorley, B
Ward, W
Simmons, SO
Vallanat, B
Veronesi, B
AF Chorley, Brian
Ward, William
Simmons, Steven O.
Vallanat, Beena
Veronesi, Bellina
TI The cellular and genomic response of rat dopaminergic neurons (N27) to
coated nanosilver
SO NEUROTOXICOLOGY
LA English
DT Article
DE Nanotoxicity; Nanosilver; "Capping"; Surface coating;
Polyvinylpyrrolidone
ID SILVER NANOPARTICLES; PARKINSONS-DISEASE; OXIDATIVE STRESS; IN-VITRO;
PROTEOLYTIC ACTIVATION; BRAIN MICROGLIA; CULTURE MODEL; PARTICLE-SIZE;
BV2 MICROGLIA; NANO-SILVER
AB This study examined if nanosilver (nanoAg) of different sizes and coatings were differentially toxic to oxidative stress-sensitive neurons. N27 rat dopaminergic neurons were exposed (0.5-5 ppm) to a set of nanoAg of different sizes (10 nm, 75 nm) and coatings (PVP, citrate) and their physicochemical, cellular and genomic response measured. Both coatings retained their manufactured sizes in culture media, however, the zeta potentials of both sizes of PVP-coated nanoAg were significantly less electronegative than those of their citrate-coated counterparts. Markers of oxidative stress, measured at 0.5-5 ppm exposure concentrations, indicated that caspase 3/7 activity and glutathione levels were significantly increased by both sizes of PVP-coated nanoAg and by the 75 nm citrate-coated nanoAg. Both sizes of PVP-coated nanoAg also increased intra-neuronal nitrite levels and activated ARE/NRF2, a reporter gene for the oxidative stress-protection pathway. Global gene expression on N27 neurons, exposed to 0.5 ppm for 8 h, indicated a dominant effect by PVP-coated nanoAg over citrate. The 75 nm PVP-coated material altered 196 genes that were loosely associated with mitochondrial dysfunction. In contrast, the 10 nm PVP-coated nanoAg altered 82 genes that were strongly associated with NRF2 oxidative stress pathways. Less that 20% of the affected genes were shared by both sizes of PVP-coated nanoAg. These cellular and genomic findings suggest that PVP-coated nanoAg is more bioactive than citrate-coated nanoAg.. Although both sizes of PVP-coated nanoAg altered the genomic expression of N27 neurons along oxidative stress pathways, exposure to the 75 nm nanoAg favored pathways associated with mitochondrial dysfunction, whereas the 10 nm PVP-coated nanoAg affected NRF2 neuronal protective pathways. Published by Elsevier Inc.
C1 [Chorley, Brian; Simmons, Steven O.; Veronesi, Bellina] Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Ward, William; Vallanat, Beena] US EPA, Res Genom Core, Res Triangle Pk, NC 27711 USA.
RP Veronesi, B (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, B105-06, Res Triangle Pk, NC 27711 USA.
EM veronesi.bellina@epa.gov
OI Simmons, Steven/0000-0001-9079-1069
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the view of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 86
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Z9 1
U1 4
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
EI 1872-9711
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD DEC
PY 2014
VL 45
BP 12
EP 21
DI 10.1016/j.neuro.2014.08.010
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA AX5GQ
UT WOS:000346955100002
PM 25194297
ER
PT J
AU Lantz, SR
Mack, CM
Wallace, K
Key, EF
Shafer, TJ
Casida, JE
AF Lantz, Stephen R.
Mack, Cina M.
Wallace, Kathleen
Key, Ellen F.
Shafer, Timothy J.
Casida, John E.
TI Glufosinate binds N-methyl-D-aspartate receptors and increases neuronal
network activity in vitro
SO NEUROTOXICOLOGY
LA English
DT Article
DE Glufosinate; Neurotoxicity; N-Methyl-D-aspartate receptor;
N-Acetylglufosinate
ID GAMMA-SUBSTITUTED PHOSPHINOTHRICINS; COLI GLUTAMINE-SYNTHETASE;
HERBICIDE-RESISTANT CROPS; AMINO-ACID TRANSPORTERS; H-3 CGP-39653
BINDING; RAT-BRAIN; ESCHERICHIA-COLI; MEDIATED EXCITOTOXICITY;
MICROELECTRODE ARRAYS; SEVERE NEUROTOXICITY
AB Glufosinate (GLF) at high levels in mammals causes convulsions and amnesia through a mechanism that is not completely understood. The structural similarity of GLF to glutamate (GLU) implicates the glutamatergic system as a target for GLF neurotoxicity. The current work examined in vitro GLF interaction with N-methyl-D-aspartate subtype GLU receptors (NMDARs) and GLT-1 transporters via [H-3]CGP 39653 binding experiments and [H-3]GLU uptake assays, respectively. GLF effects on neuronal network activity were assessed using microelectrode array (MEA) recordings in primary cultures of cortical neurons. GLF and its primary metabolite N-acetylglufosinate (NAcGLF) bind to the NMDAR; the IC50 value for GLF was 668 mu M and for NAcGLF was about 100 mu M. Concentrations of GLF greater than 1000 mu M were needed to decrease,GLU uptake through GLT-1. In MEA recordings from networks of rat primary cortical neurons, the concentration-responses for NMDA, GLF and NAcGLF on network mean firing rates (MFR) were biphasic, increasing at lower concentrations and decreasing below control levels at higher concentrations. Increases in MFR occurred between 3-10 mu M NMDA (290% control, maximum), 100-300 mu M NAcGLF (190% control, maximum) and 10-1000 mu M GLF (340% control, maximum). The NMDAR antagonist MK801 attenuated both NMDA and GLF increases in MFR. The GLF concentration required to alter GLU transport through GLT-1 is not likely to be attained in vivo, and therefore not relevant to the neurotoxic mode of action. However, toxicokinetic data from reports of intentional human poisonings indicate that GLF concentrations in the CNS after acute exposure could reach levels high enough to lead to effects mediated via NMDARs. Furthermore, the newly characterized action of NAcGLF at the NMDAR suggests that both the parent compound and metabolite could contribute to neurotoxicity via this pathway. Published by Elsevier Inc.
C1 [Lantz, Stephen R.; Key, Ellen F.; Casida, John E.] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Environm Chem & Toxicol Lab, Berkeley, CA 94720 USA.
[Mack, Cina M.; Wallace, Kathleen; Shafer, Timothy J.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Lantz, SR (reprint author), US Fish & Wildlife Serv, Marquette Biol Stn, 3090 Wright St, Marquette, MI 49855 USA.
EM stephen_lantz@fws.gov
OI Shafer, Timothy/0000-0002-8069-9987
FU STAR Fellowship Assistance - U.S. Environmental Protection Agency (EPA)
[FP917139]; UC Berkeley Sponsored Project for Undergraduate Research
(SPUR) Grant
FX S.R.L. was funded by STAR Fellowship Assistance Agreement number
FP917139 awarded by the U.S. Environmental Protection Agency (EPA).
E.F.K. was funded by a UC Berkeley Sponsored Project for Undergraduate
Research (SPUR) Grant. This document has been reviewed by the U.S. EPA's
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
The findings and conclusions in this article are those of the authors
and do not necessarily represent the views of the U.S. Fish and Wildlife
Service.
NR 71
TC 6
Z9 6
U1 4
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
EI 1872-9711
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD DEC
PY 2014
VL 45
BP 38
EP 47
DI 10.1016/j.neuro.2014.09.003
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA AX5GQ
UT WOS:000346955100005
PM 25268653
ER
PT J
AU Reich, BJ
Chang, HH
Foley, KM
AF Reich, Brian J.
Chang, Howard H.
Foley, Kristen M.
TI A Spectral Method for Spatial Downscaling
SO BIOMETRICS
LA English
DT Article
DE Computer model output; Data fusion; Kriging; Multiscale analysis
ID AIR-POLLUTION; NUMERICAL-MODELS; OUTPUT; OZONE; SENSITIVITY; COMPONENT
AB Complex computer models play a crucial role in air quality research. These models are used to evaluate potential regulatory impacts of emission control strategies and to estimate air quality in areas without monitoring data. For both of these purposes, it is important to calibrate model output with monitoring data to adjust for model biases and improve spatial prediction. In this article, we propose a new spectral method to study and exploit complex relationships between model output and monitoring data. Spectral methods allow us to estimate the relationship between model output and monitoring data separately at different spatial scales, and to use model output for prediction only at the appropriate scales. The proposed method is computationally efficient and can be implemented using standard software. We apply the method to compare Community Multiscale Air Quality (CMAQ) model output with ozone measurements in the United States in July 2005. We find that CMAQ captures large-scale spatial trends, but has low correlation with the monitoring data at small spatial scales.
C1 [Reich, Brian J.] N Carolina State Univ, Raleigh, NC 27695 USA.
[Chang, Howard H.] Emory Univ, Atlanta, GA 30322 USA.
[Foley, Kristen M.] US EPA, Washington, DC 20460 USA.
RP Reich, BJ (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA.
EM bjreich@ncsu.edu
FU USEPA [R835228, R834799]; NSF [1107046]; NIH [R01ES014843, R01ES019897,
R21ES022795-01A1]; United States Environmental Protection Agency through
its Office of Research and Development
FX The authors thank James Hodges (University of Minnesota) and Joseph
Guinness (North Carolina State University) for fruitful discussions
about this work. This study was partially supported by USEPA grants
R835228 and R834799, NSF grant 1107046, and NIH grants R01ES014843,
R01ES019897, and R21ES022795-01A1. Its contents are solely the
responsibility of the grantee and do not necessarily represent the
official views of the USEPA. Further, USEPA does not endorse the
purchase of any commercial products or services mentioned in the
publication. The United States Environmental Protection Agency through
its Office of Research and Development partially funded and collaborated
in the research described here. It has been subjected to Agency review
and approved for publication.
NR 44
TC 3
Z9 3
U1 1
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0006-341X
EI 1541-0420
J9 BIOMETRICS
JI Biometrics
PD DEC
PY 2014
VL 70
IS 4
BP 932
EP 942
DI 10.1111/biom.12196
PG 11
WC Biology; Mathematical & Computational Biology; Statistics & Probability
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
Biology; Mathematics
GA AX3GF
UT WOS:000346827500017
PM 24965037
ER
PT J
AU Daston, GP
Beyer, BK
Carney, EW
Chapin, RE
Friedman, JM
Piersma, AH
Rogers, JM
Scialli, AR
AF Daston, George P.
Beyer, Bruce K.
Carney, Edward W.
Chapin, Robert E.
Friedman, Jan M.
Piersma, Aldert H.
Rogers, John M.
Scialli, Anthony R.
TI Exposure-Based Validation List for Developmental Toxicity Screening
Assays
SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE in vitro methods; validation; developmental toxicity
ID TRANS-RETINOIC ACID; SPRAGUE-DAWLEY RATS; ETHYLENE-GLYCOL; PREGNANT
RATS; NONLINEAR PHARMACOKINETICS; PRENATAL TOXICITY; EMBRYOTOXICITY;
ARTESUNATE; SACCHARIN; KINETICS
AB Validation of alternative assays requires comparison of the responses to toxicants in the alternative assay with in vivo responses. Chemicals have been classified as positive or negative in vivo, despite the fact that developmental toxicity is conditional on magnitude of exposure. We developed a list of positive and negative developmental exposures, with exposure defined by toxicokinetic data, specifically maternal plasma C-max. We selected a series of 20 chemicals that caused developmental toxicity and for which there were appropriate toxicokinetic data. Where possible, we used the same chemical for both positive and negative exposures, the positive being the C-max at a dose level that produced significant teratogenicity or embryolethality, the negative being the C-max at a dose level not causing developmental toxicity. It was not possible to find toxicokinetic data at the no-effect level for all positive compounds, and the negative exposure list contains C-max values for some compounds that do not have developmental toxicity up to the highest dose level tested. This exposure-based reference list represents a fundamentally different approach to the evaluation of alternative tests and is proposed as a step toward application of alternative tests in quantitative risk assessment (C) 2014 Wiley Periodicals, Inc.
C1 [Daston, George P.] Procter & Gamble, Cincinnati, OH USA.
[Beyer, Bruce K.] Sanofi US Inc, Dept Disposit Safety & Anim Res Preclin Safety, Bridgewater, NJ USA.
[Carney, Edward W.] Dow Chem Co USA, Midland, MI 48674 USA.
[Chapin, Robert E.] Pfizer Worldwide R&D, Groton, CT USA.
[Friedman, Jan M.] Univ British Columbia, Dept Med Genet, Child & Family Res Inst, Vancouver, BC V5Z 1M9, Canada.
[Piersma, Aldert H.] RIVM, Utrecht, Netherlands.
[Piersma, Aldert H.] Univ Utrecht, IRAS, Utrecht, Netherlands.
[Rogers, John M.] US EPA, Tox Assessment Div, NHEERL, ORD, Res Triangle Pk, NC 27711 USA.
[Scialli, Anthony R.] Reprod Toxicol Ctr, Washington, DC USA.
[Scialli, Anthony R.] George Washington Univ, Sch Med, Washington, DC USA.
RP Scialli, AR (reprint author), Reprod Toxicol Ctr, 2737 Devonshire Pl NW 120, Washington, DC 20008 USA.
EM reprotox@reprotox.org
OI Friedman, Jan/0000-0002-7482-9570
FU HESI DART Technical Committee
FX Grant sponsor: HESI DART Technical Committee.
NR 52
TC 8
Z9 8
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-9733
EI 1542-9741
J9 BIRTH DEFECTS RES B
JI Birth Defects Res. Part B-Dev. Reprod. Toxicol.
PD DEC
PY 2014
VL 101
IS 6
BP 423
EP 428
DI 10.1002/bdrb.21132
PG 6
WC Oncology; Genetics & Heredity; Toxicology
SC Oncology; Genetics & Heredity; Toxicology
GA AX1KF
UT WOS:000346705300003
PM 25475026
ER
PT J
AU Snyder, M
Arunachalam, S
Isakov, V
Talgo, K
Naess, B
Valencia, A
Omary, M
Davis, N
Cook, R
Hanna, A
AF Snyder, Michelle
Arunachalam, Saravanan
Isakov, Vlad
Talgo, Kevin
Naess, Brian
Valencia, Alejandro
Omary, Mohammad
Davis, Neil
Cook, Rich
Hanna, Adel
TI Creating Locally-Resolved Mobile-Source Emissions Inputs for Air Quality
Modeling in Support of an Exposure Study in Detroit, Michigan, USA
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE dispersion models; mobile-source emissions; uncertainties in emissions;
R-LINE; human exposure; NEXUS
ID NEAR-ROAD EXPOSURES; DISPERSION MODEL; POLLUTANTS; NEXUS
AB This work describes a methodology for modeling the impact of traffic-generated air pollutants in an urban area. This methodology presented here utilizes road network geometry, traffic volume, temporal allocation factors, fleet mixes, and emission factors to provide critical modeling inputs. These inputs, assembled from a variety of sources, are combined with meteorological inputs to generate link-based emissions for use in dispersion modeling to estimate pollutant concentration levels due to traffic. A case study implementing this methodology for a large health study is presented, including a sensitivity analysis of the modeling results reinforcing the importance of model inputs and identify those having greater relative impact, such as fleet mix. In addition, an example use of local measurements of fleet activity to supplement model inputs is described, and its impacts to the model outputs are discussed. We conclude that with detailed model inputs supported by local traffic measurements and meteorology, it is possible to capture the spatial and temporal patterns needed to accurately estimate exposure from traffic-related pollutants.
C1 [Snyder, Michelle; Arunachalam, Saravanan; Talgo, Kevin; Naess, Brian; Valencia, Alejandro; Omary, Mohammad; Davis, Neil; Hanna, Adel] Univ N Carolina, Inst Environm, Chapel Hill, NC 27517 USA.
[Isakov, Vlad] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Cook, Rich] US EPA, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA.
RP Snyder, M (reprint author), Univ N Carolina, Inst Environm, 100 Europa Dr,Suite 490, Chapel Hill, NC 27517 USA.
EM michellesnyder@unc.edu; sarav@email.unc.edu; isakov.vlad@epa.gov;
talgo@email.unc.edu; naess@unc.edu; valenal@email.unc.edu;
omary@email.unc.edu; Neda@dtu.dk; cook.rich@epa.gov;
ahanna@email.unc.edu
OI Davis, Neil/0000-0001-5886-247X
FU U.S. Environmental Protection Agency [EP-D-07-102, EP-W-09-023]
FX The authors would like to thank Stuart Batterman and his team at the
University of Michigan for their collaboration and efforts in NEXUS. We
would also like to thank Bok Haeng Baek of the UNC's Institute for the
Environment for assistance with the NEI's temporal profiles, the
Southeast Michigan Council of Government (SEMCOG) for providing the TDM
outputs, and the Michigan DOT for providing the PTR data used in the
sensitivity analyses. The U.S. Environmental Protection Agency, through
its Office of Research and Development, partially funded and
collaborated in the research described here under Contract Nos.
EP-D-07-102 and EP-W-09-023 to the University of North Carolina at
Chapel Hill. This paper has been subjected to Agency review and approved
for publication. Approval does not signify that the contents reflect the
views of the Agency nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 17
TC 3
Z9 3
U1 2
U2 5
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2014
VL 11
IS 12
BP 12739
EP 12766
DI 10.3390/ijerph111212739
PG 28
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AX2TJ
UT WOS:000346797100043
PM 25501000
ER
PT J
AU Lane, CR
Liu, HX
Autrey, BC
Anenkhonov, OA
Chepinoga, VV
Wu, QS
AF Lane, Charles R.
Liu, Hongxing
Autrey, Bradley C.
Anenkhonov, Oleg A.
Chepinoga, Victor V.
Wu, Qiusheng
TI Improved Wetland Classification Using Eight-Band High Resolution
Satellite Imagery and a Hybrid Approach
SO REMOTE SENSING
LA English
DT Article
DE Selenga River delta; Lake Baikal; coastal band; NIR2 band; NDVI;
grey-level co-occurrence matrix; image texture; Worldview-2
ID THEMATIC MAPPER IMAGERY; SUBPIXEL CLASSIFICATION; MAPPING WETLANDS;
UNITED-STATES; ETM+ IMAGERY; TM IMAGERY; WORLDVIEW-2; VEGETATION; TREES;
AREA
AB Although remote sensing technology has long been used in wetland inventory and monitoring, the accuracy and detail level of wetland maps derived with moderate resolution imagery and traditional techniques have been limited and often unsatisfactory. We explored and evaluated the utility of a newly launched high-resolution, eight-band satellite system (Worldview-2; WV2) for identifying and classifying freshwater deltaic wetland vegetation and aquatic habitats in the Selenga River Delta of Lake Baikal, Russia, using a hybrid approach and a novel application of Indicator Species Analysis (ISA). We achieved an overall classification accuracy of 86.5% (Kappa coefficient: 0.85) for 22 classes of aquatic and wetland habitats and found that additional metrics, such as the Normalized Difference Vegetation Index and image texture, were valuable for improving the overall classification accuracy and particularly for discriminating among certain habitat classes. Our analysis demonstrated that including WV2's four spectral bands from parts of the spectrum less commonly used in remote sensing analyses, along with the more traditional bandwidths, contributed to the increase in the overall classification accuracy by similar to 4% overall, but with considerable increases in our ability to discriminate certain communities. The coastal band improved differentiating open water and aquatic (i.e., vegetated) habitats, and the yellow, red-edge, and near-infrared 2 bands improved discrimination among different vegetated aquatic and terrestrial habitats. The use of ISA provided statistical rigor in developing associations between spectral classes and field-based data. Our analyses demonstrated the utility of a hybrid approach and the benefit of additional bands and metrics in providing the first spatially explicit mapping of a large and heterogeneous wetland system.
C1 [Lane, Charles R.; Autrey, Bradley C.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Liu, Hongxing; Wu, Qiusheng] US EPA, Dynamac Corp, Cincinnati, OH 45268 USA.
[Liu, Hongxing; Wu, Qiusheng] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA.
[Anenkhonov, Oleg A.] Russian Acad Sci, Inst Gen & Expt Biol, Siberian Branch, Ulan Ude 670047, Russia.
[Chepinoga, Victor V.] Irkutsk State Univ, Dept Bot & Genet, Irkutsk 664003, Russia.
[Chepinoga, Victor V.] Russian Acad Sci, Inst Geog, Siberian Branch, Irkutsk 664003, Russia.
RP Lane, CR (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM Lane.Charles@epa.gov; Liu.Hongxing@epa.gov; Autrey.Brad@epa.gov;
Anen@yandex.ru; victor.chepinoga@gmail.com; Wu.Qiusheng@epa.gov
RI Wu, Qiusheng/C-7976-2016; Anenkhonov, Oleg/J-8690-2016
OI Wu, Qiusheng/0000-0001-5437-4073; Anenkhonov, Oleg/0000-0001-8633-7154
FU U.S. Environmental Protection Agency Office of Research and Development
[EP-D-06-096]; U.S. Department of State, Biochemical Redirect Program;
International Science and Technology Center, Moscow, Russia
FX The U.S. Environmental Protection Agency Office of Research and
Development partially funded and collaborated in the research described
here under contract number EP-D-06-096 to Dynamac Corporation. The
research conducted herein was also partially funded by the U.S.
Department of State, Biochemical Redirect Program with support from the
International Science and Technology Center, Moscow, Russia. We
appreciate the technical review and feedback provided by John Lin, U.S.
EPA, and the programmatic support of Doug Steele, U.S. EPA. This paper
has been reviewed in accordance with the U.S. Environmental Protection
Agency's peer and administrative review policies and approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. Statements in this
publication reflect the authors' professional views and opinions and
should not be construed to represent any determination or policy of the
U.S. Environmental Protection Agency.
NR 68
TC 9
Z9 10
U1 7
U2 42
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-4292
J9 REMOTE SENS-BASEL
JI Remote Sens.
PD DEC
PY 2014
VL 6
IS 12
BP 12187
EP 12216
DI 10.3390/rs61212187
PG 30
WC Remote Sensing
SC Remote Sensing
GA AX2ST
UT WOS:000346795300024
ER
PT J
AU Eudy, AM
Vines, AI
Dooley, MA
Cooper, GS
Parks, CG
AF Eudy, A. M.
Vines, A. I.
Dooley, M. A.
Cooper, G. S.
Parks, C. G.
TI Elevated C-reactive protein and self-reported disease activity in
systemic lupus erythematosus
SO LUPUS
LA English
DT Article
DE Systemic lupus erythematosus; C-reactive protein; flares; socioeconomic
factors
ID ERYTHROCYTE SEDIMENTATION-RATE; SOUTHEASTERN UNITED-STATES;
RHEUMATOID-ARTHRITIS; ACTIVITY QUESTIONNAIRE; SOCIOECONOMIC-STATUS;
REVISED CRITERIA; HEALTH; DAMAGE; VALIDATION; AMERICAN
AB C-reactive protein (CRP), a biomarker of inflammation, has been associated with increased disease activity in rheumatoid arthritis. However, the association in systemic lupus erythematosus (SLE) remains unclear. We examined the association of CRP with self-reported disease activity in the Carolina Lupus Study and described differences by sociodemographic characteristics. The study included baseline and three-year follow-up data on 107 African-American and 69 Caucasian SLE patients enrolled at a median 13 months since diagnosis. Models estimated prevalence differences in the association of baseline CRP with self-reported flares, adjusting for age, sex, race and education. Active disease or flare was reported by 59% at baseline and 58% at follow-up. Higher CRP (> 10 mu g/ml vs. <3 mu g/ml) was associated with a 17% (95% confidence interval (CI): -20, 53%) higher prevalence of flare at baseline and a 26% (95% CI: -9, 62%) higher prevalence of flare at follow-up. These CRP-flare associations were notably stronger in patients with lower education at baseline and in African-Americans at follow-up. These findings suggest that CRP may be a useful marker in studies of SLE health disparities.
C1 [Eudy, A. M.; Vines, A. I.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA.
[Dooley, M. A.] Univ N Carolina, Chapel Hill, NC 27599 USA.
[Cooper, G. S.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Parks, C. G.] NIEHS, Epidemiol Branch, NIH, DHHS, Durham, NC USA.
RP Eudy, AM (reprint author), Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Campus Box 7435, Chapel Hill, NC 27599 USA.
EM aeudy@email.unc.edu
OI Eudy, Amanda/0000-0002-3107-5545; Parks, Christine/0000-0002-5734-3456
FU Intramural Research Program of the NIEHS; National Center for Minority
Health and Health Disparities of the NIH
FX This work was supported by the Intramural Research Program of the NIEHS
and the National Center for Minority Health and Health Disparities of
the NIH.
NR 36
TC 3
Z9 3
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0961-2033
EI 1477-0962
J9 LUPUS
JI Lupus
PD DEC
PY 2014
VL 23
IS 14
BP 1460
EP 1467
DI 10.1177/0961203314543915
PG 8
WC Rheumatology
SC Rheumatology
GA AW3HK
UT WOS:000346177000003
PM 25057037
ER
PT J
AU Schaa, KL
Anderson, G
Alt-White, AC
Kasper, CE
Boyd, AM
AF Schaa, Kendra L.
Anderson, Gwen
Alt-White, Anna C.
Kasper, Christine E.
Boyd, Andrea M.
TI Genomics education for Veterans Affairs nurses
SO GENETICS IN MEDICINE
LA English
DT Letter
C1 [Anderson, Gwen; Alt-White, Anna C.; Kasper, Christine E.] Off Nursing Serv, Dept Vet Affairs, Washington, DC USA.
[Boyd, Andrea M.] Wm Jennings Bryan Dorn VA Med Ctr, Dept Vet Affairs, Columbia, SC USA.
RP Schaa, KL (reprint author), US EPA, Off Res & Dev, Dept Vet Affairs, Washington, DC 20460 USA.
EM Kendra.schaa@va.gov
OI Schaa, Kendra/0000-0002-4460-5357; Anderson, Gwen/0000-0003-2046-3152
NR 3
TC 1
Z9 1
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1098-3600
EI 1530-0366
J9 GENET MED
JI Genet. Med.
PD DEC
PY 2014
VL 16
IS 12
BP 984
EP 985
DI 10.1038/gim.2014.142
PG 2
WC Genetics & Heredity
SC Genetics & Heredity
GA AW1HN
UT WOS:000346040900019
PM 25469615
ER
PT J
AU Baker, KR
Hawkins, A
Kelly, JT
AF Baker, Kirk R.
Hawkins, Andy
Kelly, James T.
TI Photochemical grid model performance with varying horizontal grid
resolution and sub-grid plume treatment for the Martins Creek nearfield
SO2 study
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE CAMx; Dispersion; Air quality modeling; Grid resolution; Sub-grid plume;
Martins Creek
ID MESOSCALE METEOROLOGICAL MODEL; ATMOSPHERIC BOUNDARY-LAYER; NONLOCAL
CLOSURE-MODEL; LAND-SURFACE MODEL; PART II; DISPERSION MODEL;
POWER-PLANT; SCALE; TRANSPORT; SCHEME
AB Near source modeling is needed to assess primary and secondary pollutant impacts from single sources and single source complexes. Source receptor relationships need to be resolved from tens of meters to tens of kilometers. Dispersion models are typically applied for near-source primary pollutant impacts but lack complex photochemistry. Photochemical models provide a realistic chemical environment but are typically applied using grid cell sizes that may be larger than the distance between sources and receptors. It is important to understand the impacts of grid resolution and sub-grid plume treatments on photochemical modeling of near-source primary pollution gradients. Here, the CAMx photochemical grid model is applied using multiple grid resolutions and sub-grid plume treatment for SO2 and compared with a receptor mesonet largely impacted by nearby sources approximately 3-17 km away in a complex terrain environment. Measurements are compared with model estimates of SO2 at 4- and 1-km resolution, both with and without sub-grid plume treatment and inclusion of finer two-way grid nests. Annual average estimated SO2 mixing ratios are highest nearest the sources and decrease as distance from the sources increase. In general, CAMx estimates of SO2 do not compare well with the near-source observations when paired in space and time. Given the proximity of these sources and receptors, accuracy in wind vector estimation is critical for applications that pair pollutant predictions and observations in time and space. In typical permit applications, predictions and observations are not paired in time and space and the entire distributions of each are directly compared. Using this approach, model estimates using 1-km grid resolution best match the distribution of observations and are most comparable to similar studies that used dispersion and Lagrangian modeling systems. Model-estimated SO2 increases as grid cell size decreases from 4 km to 250 m. However, it is notable that the 1-km model estimates using 1-km meteorological model input are higher than the 1-km model simulation that used interpolated 4-km meteorology. The inclusion of sub-grid plume treatment did not improve model skill in predicting SO2 in time and space and generally acts to keep emitted mass aloft. Published by Elsevier Ltd.
C1 [Baker, Kirk R.; Kelly, James T.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Hawkins, Andy] US EPA, Lenexa, KS 66219 USA.
RP Baker, KR (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM baker.kirk@epa.gov
RI Kelly, James/F-8135-2010
OI Kelly, James/0000-0001-6574-5714
NR 36
TC 2
Z9 3
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 99
BP 148
EP 158
DI 10.1016/j.atmosenv.2014.09.064
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU7TS
UT WOS:000345804400017
ER
PT J
AU Jing, P
Lu, ZF
Xing, J
Streets, DG
Tan, Q
O'Brien, T
Kamberos, J
AF Jing, Ping
Lu, Zifeng
Xing, Jia
Streets, David G.
Tan, Qian
O'Brien, Timothy
Kamberos, Joseph
TI Response of the summertime ground-level ozone trend in the Chicago area
to emission controls and temperature changes, 2005-2013
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Ozone trend; Temperature dependence of ozone; NOx and VOC emission
control; Chicago
ID UNITED-STATES; MONITORING INSTRUMENT; NOX EMISSIONS; URBAN AREAS;
POWER-PLANTS; MEXICO-CITY; METEOROLOGY; RETRIEVALS; STRATEGIES;
INDUSTRIAL
AB Despite strenuous efforts to reduce the emissions of ozone precursors such as nitrogen oxides (NOx), concentrations of ground-level ozone (O-3) still often exceed the National Ambient Air Quality Standard in U.S. cities in summertime, including Chicago. Furthermore, studies have projected a future increase in O-3 formation due to global climate change. This study examines the response of summertime O-3 to emission controls and temperature change in the Chicago area from 2005 to 2013 by employing observations of O-3, O-3 precursors, and meteorological variables. We find that meteorology explains about 53% of the O-3 variance in Chicago. O-3 mixing ratios over Chicago are found to show no clear decline over the 2005-2013 period. The summertime ground-level O-3 trend consists of a decrease of 0.08 ppb/year between 2005 and 2009 and an increase of 1.49 ppb/year between 2009 and 2013. Emissions of NOx and concentrations of NO2 have been decreasing steadily from 2005 to 2013 in the Chicago area. Concentrations of volatile organic compounds (VOCs) in Chicago, however, have more than doubled since 2009, even though emission inventories suggest that VOC emissions have decreased. We believe that O-3 production in Chicago became more sensitive to VOCs starting in 2008/2009 and may have switched from being NOx-limited to VOC-limited. The warmer climate since 2008 has also contributed to the increasing ozone trend in the Chicago area. Increased attention should be paid to improving the quantification of VOC sources, enhancing the monitoring of reactive VOC concentrations, and designing VOC mitigation measures. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Jing, Ping; Kamberos, Joseph] Loyola Univ, Inst Environm Sustainabil, Chicago, IL 60660 USA.
[Lu, Zifeng; Streets, David G.] Argonne Natl Lab, Decis & Informat Sci Div, Argonne, IL 60439 USA.
[Xing, Jia] US EPA, Res Triangle Pk, NC 27711 USA.
[Tan, Qian] NASA, Goddard Earth Sci Technol & Res GESTAR Studies &, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[O'Brien, Timothy] Loyola Univ, Dept Math & Stat, Chicago, IL 60660 USA.
RP Jing, P (reprint author), Loyola Univ, Inst Environm Sustainabil, Chicago, IL 60660 USA.
EM pjing@luc.edu
RI xing, jia/O-1784-2014
FU Loyola University Chicago Summer Research Stipends
FX This work was funded by the Loyola University Chicago Summer Research
Stipends. We thank Gao Chen from NASA's Langley Research Center for
helpful comments.
NR 37
TC 5
Z9 5
U1 7
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 99
BP 630
EP 640
DI 10.1016/j.atmosenv.2014.10.035
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU7TS
UT WOS:000345804400066
ER
PT J
AU Wall, EH
Hewitt, SC
Case, LK
Lin, CY
Korach, KS
Teuscher, C
AF Wall, Emma H.
Hewitt, Sylvia C.
Case, Laure K.
Lin, Chin-Yo
Korach, Kenneth S.
Teuscher, Cory
TI The role of genetics in estrogen responses: a critical piece of an
intricate puzzle
SO FASEB JOURNAL
LA English
DT Review
DE genotype; reproductive tissue
ID MAMMARY-GLAND DEVELOPMENT; ESTRADIOL-REGULATED RESPONSES; QUANTITATIVE
TRAIT LOCI; BREAST-CANCER CELLS; X ACI INTERCROSS; RECEPTOR-ALPHA;
FEMALE MICE; IN-VIVO; OPPOSITE-SEX; BISPHENOL-A
AB The estrogens are female sex hormones that are involved in a variety of physiological processes, including reproductive development and function, wound healing, and bone growth. They are mainly known for their roles in reproductive tissues-specifically, 17 beta-estradiol (E-2), the primary estrogen, which is secreted by the ovaries and induces cellular proliferation and growth of the uterus and mammary glands. In addition to the role of estrogens in promoting tissue growth and development during normal physiological states, they have a well-established role in determining susceptibility to disease, particularly cancer, in reproductive tissues. The responsiveness of various tissues to estrogen is genetically controlled, with marked quantitative variation observed across multiple species, including humans. This variation presents both researchers and clinicians with a veritable physiological puzzle, the pieces of which-many of them unknown-are complex and difficult to fit together. Although genetics is known to play a major role in determining sensitivity to estrogens, there are other factors, including parent of origin and the maternal environment, that are intimately linked to heritable phenotypes but do not represent genotype, per se. The objectives of this review article were to summarize the current knowledge of the role of genotype, and uterine and neonatal environments, in phenotypic variation in the response to estrogens; to discuss recent findings and the potential mechanisms involved; and to highlight exciting research opportunities for the future.
C1 [Wall, Emma H.; Case, Laure K.; Teuscher, Cory] Univ Vermont, Dept Med & Pathol, Burlington, VT 05405 USA.
[Hewitt, Sylvia C.; Korach, Kenneth S.] US Natl Inst Hlth, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Lin, Chin-Yo] Univ Houston, Ctr Nucl Receptors & Cell Signaling, Houston, TX USA.
RP Teuscher, C (reprint author), Univ Vermont, C331 Given Med Bldg, Burlington, VT 05405 USA.
EM c.teuscher@uvm.edu
OI Korach, Kenneth/0000-0002-7765-418X
FU Intramural Research Program of the U.S. National Institutes of Health,
National Institute of Environmental Health Sciences grant [Z01ES70065]
FX This research was supported, in part, by the Intramural Research Program
of the U.S. National Institutes of Health, National Institute of
Environmental Health Sciences grant Z01ES70065.
NR 137
TC 4
Z9 4
U1 0
U2 7
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD DEC
PY 2014
VL 28
IS 12
BP 5042
EP 5054
DI 10.1096/fj.14-260307
PG 13
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA AU9EN
UT WOS:000345894500003
PM 25212221
ER
PT J
AU Harrison, MD
Miller, AJ
Groffman, PM
Mayer, PM
Kaushal, SS
AF Harrison, Melanie D.
Miller, Andrew J.
Groffman, Peter M.
Mayer, Paul M.
Kaushal, Sujay S.
TI HYDROLOGIC CONTROLS ON NITROGEN AND PHOSPHOROUS DYNAMICS IN RELICT OXBOW
WETLANDS ADJACENT TO AN URBAN RESTORED STREAM
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE denitrification; hydrology; nitrogen; phosphorus; stream restoration;
wetlands; urban
ID UPPER KLAMATH LAKE; NUTRIENT RETENTION; CONSTRUCTED WETLANDS; CHESAPEAKE
BAY; RESTORATION WETLAND; SUBSURFACE DRAINAGE; RIVERINE WETLANDS;
MISSISSIPPI RIVER; DEGRADED URBAN; DENITRIFICATION
AB Although wetlands are known to be sinks for nitrogen (N) and phosphorus (P), their function in urban watersheds remains unclear. We analyzed water and nitrate (NO3-) and phosphate (PO43-) dynamics during precipitation events in two oxbow wetlands that were created during geomorphic stream restoration in Baltimore County, Maryland that varied in the nature and extent of connectivity to the adjacent stream. Oxbow 1 (Ox1) received 1.6-4.2% and Oxbow 2 (Ox2) received 4.2-7.4% of cumulative streamflow during storm events from subsurface seepage (Ox1) and surface flow (Ox2). The retention time of incoming stormwater ranged from 0.2 to 6.7days in Ox1 and 1.8 to 4.3days in Ox2. Retention rates in the wetlands ranged from 0.25 to 2.74gN/m(2)/day in Ox1 and 0.29 to 1.94gN/m(2)/day in Ox2. Percent retention of the NO3--N load that entered the wetlands during the storm events ranged from 64 to 87% and 23 to 26%, in Ox1 and Ox2, respectively. During all four storm events, Ox1 and Ox2 were a small net source of dissolved PO43- to the adjacent stream (i.e., more P exited than entered the wetland), releasing P at a rate of 0.23-20.83mgP/m(2)/day and 3.43-24.84mgP/m(2)/day, respectively. N and P removal efficiency of the oxbows were regulated by hydrologic connectivity, hydraulic loading, and retention time. Incidental oxbow wetlands have potential to receive urban stream and storm flow and to be significant N sinks, but they may be sources of P in urban watersheds.
C1 [Harrison, Melanie D.] Univ Maryland Baltimore Cty, Dept Marine Estuarine & Environm Sci, Baltimore, MD 21250 USA.
[Miller, Andrew J.] Univ Maryland Baltimore Cty, Dept Geog & Environm Syst, Baltimore, MD 21250 USA.
[Groffman, Peter M.] Cary Inst Ecosyst Studies, Millbrook, NY 12454 USA.
[Mayer, Paul M.] US EPA, Ecol Effects Branch, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Kaushal, Sujay S.] Univ Maryland, Dept Geol, College Pk, MD 20740 USA.
[Kaushal, Sujay S.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA.
RP Harrison, MD (reprint author), NOAA, Southwest Reg Protected Resources Div, 777 Sonoma Ave, Santa Rosa, CA 95404 USA.
EM melanie.harrison@noaa.gov
OI Mayer, Paul/0000-0002-8550-1386
FU U.S. Environmental Protection Agency [CR829676]; U.S. National Science
Foundation (NSF) Long-Term Ecological Research program [DEB-0423476];
NSF Integrative Graduate Education and Research Traineeship Program
[0549469]; Maryland Sea Grant [SA7528085-U]; NSF Division of Biological
Infrastructure [DBI 06-40300]; NOAA Educational Partnership Graduate
Science Program (GSP)
FX This research was supported by grants from the U.S. Environmental
Protection Agency (CR829676), the U.S. National Science Foundation (NSF)
Long-Term Ecological Research program (DEB-0423476), the NSF Integrative
Graduate Education and Research Traineeship Program (0549469), Maryland
Sea Grant (SA7528085-U), the NSF Division of Biological Infrastructure
(DBI 06-40300), and the NOAA Educational Partnership Graduate Science
Program (GSP). We thank Dan Dillon, Dave Lewis, Lisa Martel, Daniel
Jones, Gwendolyn Sivirichi, Melissa Grese, Tamara Newcomer, Emma Noonan,
Yvette Williams, and Charlene Gavette for assistance with field and
laboratory work, and Christopher Swan for thoughtful comments and review
of the manuscript. This manuscript has been subjected to USEPA review,
but does not necessarily reflect the views of any of the funding
agencies, and no official endorsement should be inferred.
NR 79
TC 6
Z9 6
U1 10
U2 55
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1365
EP 1382
DI 10.1111/jawr.12193
PG 18
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900001
ER
PT J
AU Greathouse, EA
Compton, JE
Van Sickle, J
AF Greathouse, Effie A.
Compton, Jana E.
Van Sickle, John
TI LINKING LANDSCAPE CHARACTERISTICS AND HIGH STREAM NITROGEN IN THE OREGON
COAST RANGE: RED ALDER COMPLICATES USE OF NUTRIENT CRITERIA
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE Pacific Northwest; biogeochemistry; nutrients; rivers; streams; forests;
environmental regulations
ID CONTERMINOUS UNITED-STATES; WATER-QUALITY; PACIFIC-NORTHWEST; LAND-USE;
FORESTED WATERSHEDS; DIATOM ASSEMBLAGES; TILLAMOOK BAY; YAQUINA BAY;
DATA SETS; INDICATORS
AB Red alder (Alnus rubra), a nitrogen(N)-fixing deciduous broadleaf tree, can strongly influence N concentrations in western Oregon and Washington. We compiled a database of stream N and GIS-derived landscape characteristics in order to examine geographic variation in N across the Oregon Coast Range. Basal area of alder, expressed as a percent of watershed area, accounted for 37% and 38% of the variation in summer nitrate and total N (TN) concentrations, respectively. Relationships between alder and nitrate were strongest in winter when streamflow and landscape connections are highest. Distance to the coast and latitude, potential surrogates for sea salt inputs, and watershed area were also related to nitrate concentrations in an all-subsets regression analysis, which accounted for 46% of the variation in summer nitrate concentrations. The model with the lowest Akaike's Information Criterion did not include developed or agricultural land cover, probably because few watersheds in our database had substantial levels of these land cover classes. Our results provide evidence, at a regional scale, that background sources and processes cause many Coast Range streams to exceed proposed nutrient criteria, and that the prevalence of a single tree species (N-fixing red alder) exerts a dominant control over stream N concentrations across this region.
C1 [Greathouse, Effie A.; Compton, Jana E.; Van Sickle, John] US EPA, Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
RP Greathouse, EA (reprint author), Oregon State Univ, Dept Forest Ecosyst & Soc, 321 Richardson Hall, Corvallis, OR 97331 USA.
EM effieg@gmail.com
FU U.S. Environmental Protection Agency (USEPA)
FX Thanks to Patti Haggerty and Tad Larsen for essential assistance with
GIS analyses. Many individuals generously shared data and provided
assistance in understanding databases and dataset coding, including:
Alan Herlihy, Robbins Church, Kathy Motter, Rachael Gruen (USEPA data);
Sigrid Schwind, Allen Hamel, Richard Myzak, Steve Mrazik, Leslie
Merrick, Aaron Borisenko, Raeann Haynes, Chris Redman (OR DEQ data);
Linda Ashkenas, Sherri Johnson, Kirsten Gallo (Trask Watershed study and
USFS data); Diana Walker, Paul Measeles, Janet Ohmann (GIS layers). This
work was funded by the U.S. Environmental Protection Agency (USEPA) and
approved for publication after USEPA review. Approval does not signify
that the contents reflect the views of the agency, and the mention of
trade names or commercial products does not imply endorsement.
NR 84
TC 0
Z9 0
U1 2
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1383
EP 1400
DI 10.1111/jawr.12194
PG 18
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900002
ER
PT J
AU Jiang, Y
Frankenberger, JR
Sui, YH
Bowling, LC
AF Jiang, Yan
Frankenberger, Jane R.
Sui, Yinghui
Bowling, Laura C.
TI ESTIMATION OF NONPOINT SOURCE NITRATE CONCENTRATIONS IN INDIANA RIVERS
BASED ON AGRICULTURAL DRAINAGE IN THE WATERSHED
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE agricultural nitrate; nonpoint source; tile drainage; regression model
ID GULF-OF-MEXICO; MISSISSIPPI RIVER; UNITED-STATES; SAMPLING FREQUENCY;
SUBSURFACE DRAINS; NITROGEN LOADS; NUTRIENT LOADS; HYPOXIA; BASIN;
UNCERTAINTIES
AB Subsurface tile-drained agricultural fields are known to be important contributors to nitrate in surface water in the Midwest, but the effect of these fields on nitrate at the watershed scale is difficult to quantify. Data for 25 watersheds monitored by the Indiana Department of Environmental Management and located near a U.S. Geological Survey stream gage were used to investigate the relationship between flow-weighted mean concentration (FWMC) of nitrate-N and the subsurface tile-drained area (DA) of the watershed. The tile DA was estimated from soil drainage class, land use, and slope. Nitrate loads from point sources were estimated based on reported flows of major permitted facilities with mean nitrate-N concentrations from published sources. Linear regression models exhibited a statistically significant relationship between annual/monthly nonpoint source (NPS) nitrate-N and DA percentage. The annual model explained 71% of the variation in FWMC of nitrate-N. The annual and monthly models were tested in 10 additional watersheds, most with absolute errors within 1mg/l in the predicted FWMC. These models can be used to estimate NPS nitrate for unmonitored watersheds in similar areas, especially for drained agricultural areas where model performance was strongest, and to predict the nitrate reduction when various tile drainage management techniques are employed.
C1 [Jiang, Yan] US EPA, Las Vegas, NV 89118 USA.
[Frankenberger, Jane R.] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47904 USA.
[Sui, Yinghui] Purdue Univ, Dept Earth Atmospher & Planetary Sci, W Lafayette, IN 47904 USA.
[Bowling, Laura C.] Purdue Univ, Dept Agron, W Lafayette, IN 47904 USA.
RP Jiang, Y (reprint author), US EPA, 944 Harmon Ave, Las Vegas, NV 89118 USA.
EM enaj1125@gmail.com
RI Bowling, Laura/B-6963-2013
OI Bowling, Laura/0000-0002-1439-3154
NR 55
TC 3
Z9 3
U1 1
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1501
EP 1514
DI 10.1111/jawr.12216
PG 14
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900011
ER
PT J
AU Jessup, BK
Kaufmann, PR
John, F
Guevara, LS
Joseph, S
AF Jessup, Benjamin K.
Kaufmann, Philip R.
John, Forrest
Guevara, Lynette S.
Joseph, Seva
TI BEDDED SEDIMENT CONDITIONS AND MACROINVERTEBRATE RESPONSES IN NEW MEXICO
STREAMS: A FIRST STEP IN ESTABLISHING SEDIMENT CRITERIA
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE environmental impacts; Relative Bed Stability; channel morphology;
sediment; invertebrates
ID WATER-QUALITY CRITERIA; MOUNTAIN STREAMS; FINE SEDIMENT; UNITED-STATES;
BIOTIC INDEX; THRESHOLDS; REGRESSION; STABILITY; ROUGHNESS
AB Excess fine sediments in streambeds are among the most pervasive causes of degradation in streams of the United States. Simple criteria for acceptable streambed fines are elusive because streambed fines and biotic tolerances vary widely in the absence of human disturbances. In response to the need for sediment benchmarks that are protective of minimum aquatic life uses under the Clean Water Act, we undertook a case study using surveys of sediment, physical habitat, and macroinvertebrates from New Mexico streams. Our approach uses weight of evidence to develop suggested benchmarks for protective levels of surficial bedded sediments <0.06mm (silt and finer) and <2.0mm (sand and finer). We grouped streams into three ecoregions that were expected to produce similar naturally occurring streambed textures and patterns of response to human disturbances. Within ecoregions, we employed stressor response models to estimate fine sediment percentages and bed stability that are tolerated by resident macroinvertebrates. We then compared individual stream sediment data with distributions among least-disturbed reference sites to determine deviation from natural conditions, accounting for natural variability across ecoregion, gradient, and drainage area. This approach for developing benchmark values could be applied more widely to provide a solid basis for developing bedded sediment criteria and other protective management strategies in other regions.
C1 [Jessup, Benjamin K.] Tetra Tech Inc, Ctr Ecol Sci, Montpelier, VT 05602 USA.
[Kaufmann, Philip R.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab ORD, Corvallis, OR 97333 USA.
[John, Forrest] US EPA, Dallas, TX 75202 USA.
[Guevara, Lynette S.; Joseph, Seva] Surface Water Qual Bur, New Mexico Environm Dept, Santa Fe, NM 87505 USA.
RP Jessup, BK (reprint author), Tetra Tech Inc, Ctr Ecol Sci, 73 Main St,Suite 38, Montpelier, VT 05602 USA.
EM benjamin.jessup@tetratech.com
FU U.S. Environmental Protection Agency [EP-C-08-004]
FX Funding for this project was provided by the U.S. Environmental
Protection Agency through contract EP-C-08-004 to Tetra Tech, Inc. Field
survey data were provided by the U.S. Environmental Protection Agency
Wadeable Streams Assessment and Western Environmental Monitoring and
Assessment Programs. James Hogan of the New Mexico Environment
Department provided insightful suggestions and interpretations
throughout the analyses. Angel Kosfisher of EPA Region 6 conducted GIS
analyses. Erik Leppo of Tetra Tech helped in data management and
analysis. Revisions suggested by Bob Ozretich, John Faustini, Lil
Herger, and Larry Willis improved the manuscript, as did the comments
provided by the associate editor and two anonymous reviewers. This paper
was subjected to peer and administrative review at the National Health
and Environmental Effects Research Laboratory's Western Ecology Division
and approved for publication. Approval does not signify that the
contents reflect the views of the USEPA, nor does mention of trade names
or commercial products constitute endorsement or recommendation for use.
NR 45
TC 1
Z9 1
U1 1
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD DEC
PY 2014
VL 50
IS 6
BP 1558
EP 1574
DI 10.1111/jawr.12224
PG 17
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA AU7IJ
UT WOS:000345773900015
ER
PT J
AU Tollefsen, KE
Scholz, S
Cronin, MT
Edwards, SW
de Knecht, J
Crofton, K
Garcia-Reyero, N
Hartung, T
Worth, A
Patlewicz, G
AF Tollefsen, Knut Erik
Scholz, Stefan
Cronin, Mark T.
Edwards, Stephen W.
de Knecht, Joop
Crofton, Kevin
Garcia-Reyero, Natalia
Hartung, Thomas
Worth, Andrew
Patlewicz, Grace
TI Applying Adverse Outcome Pathways (AOPs) to support Integrated
Approaches to Testing and Assessment (IATA)
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Adverse Outcome Pathway (AOP); Integrated Approaches to Testing and
Assessment (IATA); (Q)SAR; Read-across; High throughput screening (HTS);
High content screening (HCS); Cross species extrapolation
ID SCREENING CONTACT ALLERGENS; ALKYLATED NON-PHENOLICS; IN-VITRO;
RISK-ASSESSMENT; CELL-LINE; SKIN SENSITIZATION; ACETYLCHOLINESTERASE
INHIBITION; DISRUPTING CHEMICALS; CONCEPTUAL-FRAMEWORK; PEPTIDE
REACTIVITY
AB Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and robust decision making demands that regulatory toxicity testing becomes more cost-effective and efficient. One way to realize this goal is by being more strategic in directing testing resources; focusing on chemicals of highest concern, limiting testing to the most probable hazards, or targeting the most vulnerable species. Hypothesis driven Integrated Approaches to Testing and Assessment (IATA) have been proposed as practical solutions to such strategic testing. In parallel, the development of the Adverse Outcome Pathway (AOP) framework, which provides information on the causal links between a molecular initiating event (MIE), intermediate key events (KEs) and an adverse outcome (AO) of regulatory concern, offers the biological context to facilitate development of IATA for regulatory decision making. This manuscript summarizes discussions at the Workshop entitled "Advancing AOPs for Integrated Toxicology and Regulatory Applications" with particular focus on the role AOPs play in informing the development of IATA for different regulatory purposes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Tollefsen, Knut Erik] Norwegian Inst Water Res NIVA, N-0349 Oslo, Norway.
[Scholz, Stefan] UFZ Helmholtz Ctr Environm Res, Dept Bioanalyt Ecotoxicol, D-04318 Leipzig, Germany.
[Cronin, Mark T.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England.
[Edwards, Stephen W.; Crofton, Kevin] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[de Knecht, Joop] Org Econ Cooperat & Dev, Environm Directorate, Environm Hlth & Safety Div, F-75775 Paris 16, France.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Hartung, Thomas] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD 21205 USA.
[Worth, Andrew] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, Syst Toxicol Unit, Ispra, Varese, Italy.
[Patlewicz, Grace] DuPont Haskell Global Ctr Hlth & Environm Sci, Newark, DE 19711 USA.
RP Patlewicz, G (reprint author), DuPont Haskell Global Ctr, Newark, DE 19711 USA.
EM knut.erik.tollefsen@niva.no; stefan.scholz@ufz.de;
M.T.Cronin@ljmu.ac.uk; Edwards.Stephen@epa.gov; Joop.DEKNECHT@oecd.org;
Crofton.Kevin@epa.gov; natalia@icnanotox.org; thartung@jhsph.edu;
Andrew.WORTH@ec.europa.eu; patlewig@hotmail.com
RI Scholz, Stefan/B-7776-2014; Crofton, Kevin/J-4798-2015;
OI Scholz, Stefan/0000-0002-6990-4716; Crofton, Kevin/0000-0003-1749-9971;
Patlewicz, Grace/0000-0003-3863-9689
FU American Chemistry Council (ACC); BioDetection Systems; European Centre
for Ecotoxicology and Toxicology of Chemicals (ECETOC); Environment
Canada; European Commission Directorate General Joint Research Centre;
Human Toxicology Project Consortium; International Life Sciences
Institute - Health and Environmental Science Institute; Research Council
of Norway [221455]; Society for Environmental Toxicology and Chemistry
(SETAC); US Army Engineer Research and Development Center; U.S.
Environmental Protection Agency
FX The content of this paper is the result of an international expert
workshop on Advancing Adverse Outcome Pathways (AOP5) for Integrated
Toxicology and Regulatory Applications. Support for the workshop was
provided by the American Chemistry Council (ACC), BioDetection Systems,
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC),
Environment Canada, European Commission Directorate General Joint
Research Centre, Human Toxicology Project Consortium, International Life
Sciences Institute - Health and Environmental Science Institute, The
Research Council of Norway (Grant No. 221455), Society for Environmental
Toxicology and Chemistry (SETAC), US Army Engineer Research and
Development Center, and the U.S. Environmental Protection Agency. The
authors acknowledge the workshop organizing committee, and all workshop
participants for both plenary and informal discussions that influenced
the content presented here. The views expressed are those of the
authors, and do not necessarily represent the views of the organizations
the authors are affiliated with or the sponsors. Mention of trade names
does not imply endorsement by any of the author organizations or
sponsors.; The participation of Tatiana Netzeva and Alberto Martin
Aparicio from the European Chemicals Agency (ECHA) in the discussions of
the workshop is also acknowledged. The views expressed at the workshop
represented the personal opinion of the experts as individual scientists
and regulatory professionals and do not constitute an official position
of ECHA.; The opinions expressed and arguments employed herein are those
of the authors and do not necessarily reflect the official views of the
OECD or the governments of its member countries.; The information in
this document has been funded wholly (or in part) by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory (NHEERL)
and approved for publication. Approval does not signify that the
contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 113
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Z9 52
U1 11
U2 49
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD DEC
PY 2014
VL 70
IS 3
BP 629
EP 640
DI 10.1016/j.yrtph.2014.09.009
PG 12
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA AU7ZO
UT WOS:000345816900007
PM 25261300
ER
PT J
AU Crump, KS
Bussard, DA
Chen, C
Jinot, J
AF Crump, Kenny S.
Bussard, D. A.
Chen, C.
Jinot, J.
TI The "bottom-up" approach does not necessarily bound low-dose risk
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Letter
C1 [Bussard, D. A.; Chen, C.; Jinot, J.] US EPA, Washington, DC 20460 USA.
RP Crump, KS (reprint author), 2220 S Vienna St, Ruston, LA 71270 USA.
EM KennyCrump@email.com; Bussard.David@epa.gov; chaochen25@comcast.net;
Jinot.Jennifer@epa.gov
NR 2
TC 1
Z9 1
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD DEC
PY 2014
VL 70
IS 3
BP 735
EP 736
DI 10.1016/j.yrtph.2014.10.008
PG 2
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA AU7ZO
UT WOS:000345816900020
PM 25455229
ER
PT J
AU Foley, KM
Napelenok, SL
Jang, C
Phillips, S
Hubbell, BJ
Fulcher, CM
AF Foley, Kristen M.
Napelenok, Sergey L.
Jang, Carey
Phillips, Sharon
Hubbell, Bryan J.
Fulcher, Charles M.
TI Two reduced form air quality modeling techniques for rapidly calculating
pollutant mitigation potential across many sources, locations and
precursor emission types
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE CMAQ-DDM; Response surface model; Emission controls; PM2.5; Ozone
ID SENSITIVITY-ANALYSIS; NONLINEAR RESPONSE; OZONE; EXPOSURE; SYSTEM;
IMPACT; CHINA
AB Due to the computational cost of running regional-scale numerical air quality models, reduced form models (RFM) have been proposed as computationally efficient simulation tools for characterizing the pollutant response to many different types of emission reductions. The U.S. Environmental Protection Agency has developed two types of reduced form models based upon simulations of the Community Multiscale Air Quality (CMAQ) modeling system. One is based on statistical response surface modeling (RSM) techniques using a multidimensional kriging approach to approximate the nonlinear chemical and physical processes. The second approach is based on using sensitivity coefficients estimated with the Decoupled Direct Method in 3 dimensions (CMAQ-DDM-3D) in a Taylor series approximation for the nonlinear response of the pollutant concentrations to changes in emissions from specific sectors and locations. Both types of reduced form models are used to estimate the changes in O-3 and PM2.5 across space associated with emission reductions of NOx and SO2 from power plants and other sectors in the eastern United States. This study provides a direct comparison of the RSM- and DDM-3D-based tools in terms of: computational cost, model performance against brute force runs, and model response to changes in emission inputs. For O-3, the DDM-3D RFM had slightly better performance on average for low to moderate emission cuts compared to the kriging-based RSM, but over-predicted O-3 disbenefits from cuts to mobile source NOx in very urban areas. The RSM approach required more up-front computational cost and produced some spurious O-3 increases in response to reductions in power plant emissions. However the RSM provided more accurate predictions for PM2.5 and for predictions of very large emission cuts (e.g. -60 to -90%). This comparison indicates that there are some important differences in the output of the two approaches that should be taken under consideration when interpreting results for a given application. Published by Elsevier Ltd.
C1 [Foley, Kristen M.; Napelenok, Sergey L.; Jang, Carey; Phillips, Sharon; Hubbell, Bryan J.; Fulcher, Charles M.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Foley, KM (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM foley.kristen@epa.gov
OI Hubbell, Bryan/0000-0002-7963-3438
NR 17
TC 3
Z9 4
U1 3
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 98
BP 283
EP 289
DI 10.1016/j.atmosenv.2014.08.046
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU2WI
UT WOS:000345475000030
ER
PT J
AU Nallathamby, PD
Lewandowski, M
Jaoui, M
Offenberg, JH
Kleindienst, TE
Rubitschun, C
Surratt, JD
Usenko, S
Sheesley, RJ
AF Nallathamby, Punith Dev
Lewandowski, Michael
Jaoui, Mohammed
Offenberg, John H.
Kleindienst, Tadeusz E.
Rubitschun, Caitlin
Surratt, Jason D.
Usenko, Sascha
Sheesley, Rebecca J.
TI Qualitative and quantitative assessment of unresolved complex mixture in
PM2.5 of Bakersfield, CA
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Southern California; Semi-volatile organic carbon; Traffic emissions;
PM2.5
ID SECONDARY ORGANIC AEROSOL; RESOLUTION GAS-CHROMATOGRAPHY; AIR-POLLUTION
SOURCES; N-ALKANES; UNITED-STATES; OIL-SPILL; EMISSIONS; HYDROCARBONS;
CALIFORNIA; SEDIMENTS
AB The 2010 CalNex (California Nexus) field experiment offered an opportunity for detailed characterization of atmospheric particulate carbon composition and sources in Bakersfield, CA. In the current study, the authors describe and employ a new protocol for reporting unresolved complex mixture (UCM) in over 30 daily samples. The Bakersfield, CA site has significant contribution from UCM, 2.9 +/- 2.2% of the daily OC, which makes it an ideal first application. The new protocol reports two UCM peaks for Bakersfield with unique mean vapor pressure, retention time, mass spectra and daily ambient concentration trends. The first UCM peak, UCM-A, was comprised of semi-volatile compounds including alkanes, alkenes, and allcynes, with a mean vapor pressure of 2E-04 Tort and medium to heavy-duty diesel exhaust as a likely source. The second UCM peak, UCM-B, was comprised of linear, branched, and cyclic alkanes, with a mean vapor pressure of 1E-08 Torr. UCM-B had strong similarities to UCM in the NIST Standard Reference Material 1649b (urban dust) and to previously reported, detailed UCM for a representative Bakersfield sample, with possible sources including: motor vehicle exhaust, agricultural activities, and construction activities. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Nallathamby, Punith Dev; Usenko, Sascha; Sheesley, Rebecca J.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA.
[Lewandowski, Michael; Offenberg, John H.; Kleindienst, Tadeusz E.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Jaoui, Mohammed] Alion Sci & Technol, Res Triangle Pk, NC USA.
[Rubitschun, Caitlin; Surratt, Jason D.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC USA.
RP Sheesley, RJ (reprint author), Baylor Univ, Dept Environm Sci, OBP 97266, Waco, TX 76798 USA.
EM rebecca_sheesley@baylor.edu
RI Surratt, Jason/D-3611-2009; Offenberg, John/C-3787-2009; Sheesley,
Rebecca/I-6655-2015; Guenat, Heather/H-6528-2014; Usenko,
Sascha/N-8730-2015;
OI Surratt, Jason/0000-0002-6833-1450; Offenberg, John/0000-0002-0213-4024;
Sheesley, Rebecca/0000-0002-8187-0571
FU U.S. Environmental Protection Agency through its Office of Research and
Development [EP-D-10-070]; Baylor University; University Research
Committee; C. Gus Glasscock, Jr. Endowed Fund for Excellence in
Environmental Sciences
FX The U.S. Environmental Protection Agency through its Office of Research
and Development funded and collaborated in the research described here
under Contract EP-D-10-070 to Alion Science and Technology. The
manuscript has been subjected to external peer review and has been
cleared for publication. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. This study
was supported in part by Baylor University funds including the
University Research Committee and the C. Gus Glasscock, Jr. Endowed Fund
for Excellence in Environmental Sciences.
NR 36
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U1 2
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 98
BP 368
EP 375
DI 10.1016/j.atmosenv.2014.09.006
PG 8
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU2WI
UT WOS:000345475000039
ER
PT J
AU Napelenok, SL
Vedantham, R
Bhave, PV
Pouliot, GA
Kwok, RHF
AF Napelenok, Sergey L.
Vedantham, Ram
Bhave, Prakash V.
Pouliot, George A.
Kwok, Roger H. F.
TI Source-receptor reconciliation of fine-particulate emissions from
residential wood combustion in the southeastern United States
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Particulate matter; Residential wood combustion; Carbon; Air quality
model; Source apportionment
ID CMAQ MODELING SYSTEM; PARTICLE EMISSIONS; AIR-QUALITY; PM2.5;
COMPONENTS; HEALTH; IMPACT; CARBON; SMOKE; MODIS
AB An extensive collection of speciated PM2.5 measurements including organic tracers permitted a detailed examination of the emissions from residential wood combustion (RWC) in the southeastern United States over an entire year (2007). The Community Multiscale Air Quality model-based Integrated Source Apportionment Method (CMAQ-ISAM) was used in combination with the U.S. National Emissions Inventory (NEI) to compute source contributions from ten categories of biomass combustion, including RWC. A novel application of the receptor-based statistical model, Unmix, was used to subdivide the observed concentrations of levoglucosan, a unique tracer of biomass combustion. Using the CMAQ-ISAM and Unmix models together, we find that the emission-based RWC contribution to ambient carbonaceous PM2.5 predicted by the model is approximately a factor of two lower than indicated by observations. Recommendations for improving the temporal allocation of the emissions are proposed and tested to show a potential improvement in model RWC predictions, quantified by approximately 15% less bias. Further improvements in the sector predictions could be achieved with a survey-based analysis of detailed RWC emission patterns. Published by Elsevier Ltd.
C1 [Napelenok, Sergey L.; Vedantham, Ram; Bhave, Prakash V.; Pouliot, George A.; Kwok, Roger H. F.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Napelenok, SL (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM napelenok.sergey@epa.gov
NR 23
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2014
VL 98
BP 454
EP 460
DI 10.1016/j.atmosenv.2014.09.021
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AU2WI
UT WOS:000345475000049
ER
PT J
AU Christensen, K
Sobus, J
Phillips, M
Blessinger, T
Lorber, M
Tan, YM
AF Christensen, Krista
Sobus, Jon
Phillips, Martin
Blessinger, Todd
Lorber, Matthew
Tan, Yu-Mei
TI Changes in epidemiologic associations with different exposure metrics: A
case study of phthalate exposure associations with body mass index and
waist circumference
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Exposure metric; Phthalates; BMI; WC; Bias
ID HUMAN HEALTH-RISKS; DI(2-ETHYLHEXYL)PHTHALATE DEHP; BISPHENOL-A;
ENVIRONMENTAL CONTAMINANTS; URINARY CONCENTRATIONS; LIPID ADJUSTMENT;
METABOLITES; SAMPLES; VARIABILITY; CHILDREN
AB The use of human biomonitoring data to characterize exposure to environmental contaminants in epidemiology studies has expanded greatly in recent years. Substantial variability in effect measures may arise when using different exposure metrics for a given contaminant, and it is often not clear which metric is the best surrogate for the 'causal' or 'true' exposure. Here we evaluated variability and potential bias in epidemiologic associations resulting from the use of different phthalate exposure metrics in the 2009-2010 National Health and Nutrition Examination Survey (NHANES). We examined associations between urinary phthalate metabolites and the outcomes of body mass index (BMI) and waist circumference (WC). We examined each of the following NHANES-derived exposure metrics for metabolites of individual phthalates: molar excretion rate (nmol/min), molar amount (nmol), molar concentration (nmol/mL, with and without additional model adjustment for creatinine), creatinine corrected molar concentration (nmol/g creatinine), and reconstructed daily phthalate intake (nmol/kg/day). In order to investigate potential biasing effect of each metric, we first assumed that daily intake of the parent phthalate is the causal exposure. We then constructed a simulated population based on the 2009-2010 NHANES, and randomly assigned each individual a di-2-ethylhexyl phthalate (DEHP) intake dose based on a published distribution, but independent of any other factor. Accordingly, all associations between these randomly assigned intake doses and individuals' BMI and WC should be null. Next, demographic data in the NHANES were incorporated into a pharmacokinetic model to predict urinary molar excretions of five DEHP metabolites based on the randomly assigned DEHP intake. The predicted molar excretions were then used to calculate the same exposure metrics listed above. Three exposure metrics (randomly generated intake, excretion rate, urine concentration) showed no significant associations with BMI, which supports the null hypothesis stated above. In contrast, metrics adjusted for creatinine showed a significant negative correlation, and reconstructed daily intake showed a significant positive correlation, indicating the introduction of bias away from the true (i.e., null) association. Interestingly, trends in the simulation analysis were similar to those seen in the observed NHANES data. Our findings show that, at least in this example case, the choice of exposure metric can introduce significant bias of varying magnitude and direction into the calculation of epidemiologic associations. Published by Elsevier Ltd.
C1 [Christensen, Krista; Blessinger, Todd; Lorber, Matthew] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Sobus, Jon; Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Phillips, Martin] US EPA, Natl Exposure Res Lab, Off Res & Dev, Duluth, MN USA.
RP Christensen, K (reprint author), Bur Environm & Occupat Hlth, Wisconsin Div Publ Hlth, 1 W Wilson St,Rm 150, Madison, WI 53701 USA.
OI Phillips, Martin/0000-0002-6282-529X
NR 42
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 66
EP 76
DI 10.1016/j.envint.2014.07.010
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700008
PM 25090576
ER
PT J
AU Jhun, I
Fann, N
Zanobetti, A
Hubbell, B
AF Jhun, Iny
Fann, Neal
Zanobetti, Antonella
Hubbell, Bryan
TI Effect modification of ozone-related mortality risks by temperature in
97 US cities
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Ozone; Temperature; Mortality; Effect modification; Air conditioning
ID AIR-POLLUTION; NATIONAL MORBIDITY; PARTICULATE MATTER; TIME-SERIES;
NMMAPS DATA; COMMUNITIES; METAANALYSIS; POLLUTANTS; EXPOSURE; MODIFY
AB Many time-series studies have characterized the relationship between short-term ozone exposure and adverse health outcomes, controlling for temperature as a confounder. Temperature may also modify ozone effects, though this has been largely under-investigated. In this study, we explored whether temperature modifies the effect of short-term ozone exposure on mortality. We used the database developed for the National Morbidity and Mortality Air Pollution Study to estimate ozone mortality risks in 97 US cities in May through September, 1987-2000. We treated temperature as a confounder as well as an effect modifier by estimating risks at low, moderate, and high temperature categories. When temperature was treated as a confounder, a 10-ppb increase in daily 24-h ozone was associated with a 0.47% (95% CI: 0.19%-0.76%) increase in mortality. When we assessed effect modification by temperature, the interaction between ozone and temperature was not statistically significant However, there was a U-shaped pattern in mortality risk, which was greater at the low (<25th percentile) and high (>75th percentile) temperature levels than moderate temperature levels. At the high temperature category, a 10% increase in AC prevalence mitigated mortality risk associated with 10-ppb of ozone exposure by -0.18% (95% CI: -0.35%, -0.02%). Furthermore, ozone mortality risk in the high temperature category increased as we restricted our analyses to hotter days. On days where temperatures exceeded the 75th, 90th, and 95th percentile temperatures, a 10-ppb increase in ozone was associated with a 0.65% (95% CI: 0.20%-1.09%), 0.83% (95% CI: 0.17%-1.48%), and 135% (95% CI: 0.44%-2.27%) increase in mortality, respectively. These results suggested that high temperatures may exacerbate physiological responses to short-term ozone exposure. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Jhun, Iny; Zanobetti, Antonella] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
[Fann, Neal; Hubbell, Bryan] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Jhun, I (reprint author), 401 Pk Dr,Landmark 4 West,Rm 412 J, Boston, MA 02215 USA.
EM iny@mail.harvard.edu
OI Fann, Neal/0000-0002-6724-8575; Hubbell, Bryan/0000-0002-7963-3438
FU EPA's National Network for Environmental Management Studies fellowship;
Harvard School of Public Health scholarship
FX This work was made possible by the EPA's National Network for
Environmental Management Studies fellowship and the Harvard School of
Public Health scholarship. We thank the journal reviewers for their
suggestions on the AC prevalence analyses.
NR 29
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 128
EP 134
DI 10.1016/j.envint.2014.07.009
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700015
PM 25113626
ER
PT J
AU LaKind, JS
Sobus, JR
Goodman, M
Barr, DB
Furst, P
Albertini, RJ
Arbuckle, TE
Schoeters, G
Tan, YM
Teeguarden, J
Tornero-Velez, R
Weisel, CP
AF LaKind, Judy S.
Sobus, Jon R.
Goodman, Michael
Barr, Dana Boyd
Fuerst, Peter
Albertini, Richard J.
Arbuckle, Tye E.
Schoeters, Greet
Tan, Yu-Mei
Teeguarden, Justin
Tornero-Velez, Rogelio
Weisel, Clifford P.
TI A proposal for assessing study quality: Biomonitoring, Environmental
Epidemiology, and Short-lived Chemicals (BEES-C) instrument
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE BEES-C; Biomonitoring; Ubiquitous chemicals; Short physiologic
half-life; Evaluation instrument; Environmental epidemiology
ID NUTRITION EXAMINATION SURVEY; 24-H URINE SAMPLES; BISPHENOL-A;
NONDIFFERENTIAL MISCLASSIFICATION; TEMPORAL VARIABILITY; UNITED-STATES;
MOLECULAR EPIDEMIOLOGY; PYRETHROID METABOLITES; HYPOTHESIS GENERATION;
PHTHALATE METABOLITES
AB The quality of exposure assessment is a major determinant of the overall quality of any environmental epidemiology study. The use of biomonitoring as a tool for assessing exposure to ubiquitous chemicals with short physiologic half-lives began relatively recently. These chemicals present several challenges, including their presence in analytical laboratories and sampling equipment, difficulty in establishing temporal order in cross-sectional studies, short- and long-term variability in exposures and biomarker concentrations, and a paucity of information on the number of measurements required for proper exposure classification. To date, the scientific community has not developed a set of systematic guidelines for designing, implementing and interpreting studies of short-lived chemicals that use biomonitoring as,the exposure metric or for evaluating the quality of this type of research for WOE assessments or for peer review of grants or publications. We describe key issues that affect epidemiology studies using biomonitoring data on short-lived chemicals and propose a systematic instrument - the Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument - for evaluating the quality of research proposals and studies that incorporate biomonitoring data on short-lived chemicals. Quality criteria for three areas considered fundamental to the evaluation of epidemiology studies that include biological measurements of short-lived chemicals are described: 1) biomarker selection and measurement, 2) study design and execution, and 3) general epidemiological study design considerations. We recognize that the development of an evaluative tool such as BEES-C is neither simple nor non-controversial. We hope and anticipate that the instrument will initiate further discussion/debate on this topic. (C) 2014 The Authors. Published by Elsevier Ltd.
C1 [LaKind, Judy S.] LaKind Associates LLC, Catonsville, MD 21228 USA.
[LaKind, Judy S.] Univ Maryland, Dept Epidemiol & Publ Hlth, Sch Med, College Pk, MD USA.
[LaKind, Judy S.] Penn State Univ, Dept Pediat, Coll Med, Milton S Hershey Med Ctr, University Pk, PA 16802 USA.
[Sobus, Jon R.; Tan, Yu-Mei; Tornero-Velez, Rogelio] US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA.
[Goodman, Michael] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
[Barr, Dana Boyd] Emory Univ, Rollins Sch Publ Hlth, Dept Environm & Occupat Hlth, Atlanta, GA 30322 USA.
[Fuerst, Peter] Munsterland Emscher Lippe CVUA MEL, Chem & Vet Analyt Inst, D-48151 Munster, Germany.
[Albertini, Richard J.] Univ Vermont, Coll Med, Underhill Ctr, VT 05490 USA.
[Arbuckle, Tye E.] Hlth Canada, Populat Studies Div, Hlth Environm & Consumer Safety Branch, Ottawa, ON K1A 0K9, Canada.
[Schoeters, Greet] VITO, Environm Risk & Hlth Unit, B-2400 Mol, Belgium.
[Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium.
[Teeguarden, Justin] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Weisel, Clifford P.] UMDNJ, Environm & Occupat Hlth Sci Inst, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA.
RP LaKind, JS (reprint author), LaKind Associates LLC, 106 Oakdale Ave, Catonsville, MD 21228 USA.
EM lakindassoc@gmail.com; Sobus.Jon@epa.gov; mgoodm2@emory.edu;
dbbarr@emory.edu; Peter.Fuerst@cvua-mel.de; Ralbert315@aol.com;
Tye.Arbuckle@hc-sc.gc.ca; greet.schoeters@vito.be; Tan.Cecilia@epa.gov;
jt@pnnl.gov; Tornero-Velez.Rogelio@epa.gov; weisel@eohsi.rutgers.edu
OI Teeguarden, Justin/0000-0003-3817-4391
FU Polycarbonate/BPA Global Group of the American Chemistry Council (ACC)
FX The Workshop was sponsored by Polycarbonate/BPA Global Group of the
American Chemistry Council (ACC). ACC was not involved in the design,
management, or development of the Workshop or in the preparation or
approval of the manuscript Workshop participants or their affiliated
organizations received an honorarium (except JSL, ES, GS, JS, JT, Y-MT,
RT-V, TA) and travel support (except TA, Y-MT, DB, ES). JSL received
support for Workshop development and facilitation; JSL consults to
governmental and private sectors. MG regularly serves as a consultant
for the government and for the private sector. No other competing
interests are declared.
NR 122
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U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 195
EP 207
DI 10.1016/j.envint.2014.07.011
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700023
PM 25137624
ER
PT J
AU Xue, JP
Zartarian, V
Tornero-Velez, R
Tulve, NS
AF Xue, Jianping
Zartarian, Valerie
Tornero-Velez, Rogelio
Tulve, Nicolle S.
TI EPA's SHEDS-multimedia model: Children's cumulative pyrethroid exposure
estimates and evaluation against NHANES biomarker data
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE SHEDS-Multimedia; Pyrethroids; Cumulative; Exposure; Dose; Model
ID PRESCHOOL-CHILDREN; DERMAL ABSORPTION; INSECTICIDES; PERMETHRIN;
CYPERMETHRIN; METABOLITES; POPULATION; PESTICIDES; PLAYSETS; DIETARY
AB The U.S. EPA's SHEDS-Multimedia model was applied to enhance the understanding of children's exposures and doses to multiple pyrethroid pesticides, including major contributing chemicals and pathways. This paper presents combined dietary and residential exposure estimates and cumulative doses for seven commonly used pyrethroids, and comparisons of model evaluation results with NHANES biomarker data for 3-PBA and DCCA metabolites. Model input distributions were fit to publicly available pesticide usage survey data, NHANES, and other studies, then SHEDS-Multimedia was applied to estimate total pyrethroid exposures and doses for 35 year olds for one year variability simulations. For dose estimations we used a pharmacokinetic model and two approaches for simulating dermal absorption. SHEDS-Multimedia predictions compared well to NHANES biomarker data: ratios of 3-PBA observed data to SHEDS-Multimedia modeled results were 0.88, 0.51, 0.54 and 1.02 for mean, median, 95th, and 99th percentiles, respectively; for DCCA, the ratios were 0.82, 0.53, 0.56, and 0.94. Modeled time-averaged cumulative absorbed dose of the seven pyrethroids was 3.1 nmol/day (versus 8.4 nmol/day for adults) in the general population (residential pyrethroid use and non-use homes) and 6.7 nmol/day (versus 10.5 nmol/day for adults) in the simulated residential pyrethroid use population. For the general population, contributions to modeled cumulative dose by chemical were permethrin (60%), cypermethrin (22%), and cyfluthrin (16%); for residential use homes, contributions were cypermethrin (49%), permethrin (29%), and cyfiuthrin (17%). The primary exposure route for 3-5 year olds in the simulated residential use population was non-dietary ingestion exposure; whereas for the simulated general population, dietary exposure was the primary exposure route. Below the 95th percentile, the major exposure pathway was dietary for the general population; non-dietary ingestion was the major pathway starting below the 70th percentile for the residential use population. The new dermal absorption methodology considering surface loading had some impact, but did not change the order of key pathways. Published by Elsevier Ltd.
C1 [Xue, Jianping; Zartarian, Valerie; Tornero-Velez, Rogelio; Tulve, Nicolle S.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA.
RP Xue, JP (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM xue.jianping@epa.gov
FU United States Environmental Protection Agency, through its Office of
Research and Development
FX The United States Environmental Protection Agency, through its Office of
Research and Development, funded and managed the research described
here. It has been subjected to agency administrative review and approved
for publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 30
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U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2014
VL 73
BP 304
EP 311
DI 10.1016/j.envint.2014.08.008
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU3WE
UT WOS:000345540700035
PM 25192887
ER
PT J
AU Meyer, KM
Tufts, JA
Calfee, MW
Oudejans, L
AF Meyer, K. M.
Tufts, J. A.
Calfee, M. W.
Oudejans, L.
TI Efficacy of sporicidal wipes for inactivation of a Bacillus anthracis
surrogate
SO JOURNAL OF APPLIED MICROBIOLOGY
LA English
DT Article
DE anthrax; Bacillus anthracis; Bacillus atrophaeus; biological agent;
decontamination; sporicidal wipe
ID CLOSTRIDIUM-DIFFICILE SPORES; MICROBICIDAL ACTIVITIES; ENVIRONMENTAL
SURFACES; DISINFECTION METHODS; LABORATORY-SCALE; DECONTAMINATION;
CONTAMINATION
AB AimsTo evaluate five commercially available sporicidal wipes and two disinfecting wipes for their ability to inactivate Bacillus atrophaeus spores deposited onto various material surfaces.
Methods and ResultsDecontamination efficacy of the wipes was initially tested on glass Petri dishes (150mm diameter). Following exposure for a specified time of contact, survival of the spores was assessed by quantification of the remaining viable spores, both on the coupon surface and on the towelette itself, with efficacy quantified in terms of mean log reduction. Based on these data, five wipes were down-selected for evaluation on a larger scale, using 36x36cm coupons of five different material types.
ConclusionsResults suggest that sodium hypochlorite-based sporicidal wipes were most effective, having completely inactivated the Bacillus spores on the glass Petri dish and several materials. Additionally, results demonstrate that the manufacturer-prescribed contact times for Clostridium difficile achieved a 6 log(10) reduction of B.atrophaeus spores. Moreover, commercially available disinfecting wipes were not able to kill Bacillus spores as evaluated.
Significance and Impact of the StudyThese data show the potential of sporicidal wipes for decontamination of small, contained areas of biological contamination and may help on-scene coordinators develop remediation plans following a biological terrorism event.
C1 [Meyer, K. M.; Tufts, J. A.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA.
[Calfee, M. W.; Oudejans, L.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA.
RP Oudejans, L (reprint author), US EPA, MD E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM oudejans.lukas@epa.gov
OI Calfee, Michael/0000-0001-6544-329X
FU U.S. Department of Energy; EPA
FX This research was supported in part by an appointment to the Research
Participation Program for the U.S. Environmental Protection Agency,
Office of Research and Development, administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and EPA. The authors gratefully
acknowledge the critical reviews by Shannon Serre (EPA's Office of
Research and Development on detail with EPA's Office of Emergency
Management) and Frank Schaefer (EPA's Office of Research and
Development). This manuscript has been subject to an administrative
review; the views expressed here are those of the authors and do not
reflect the view or policies of the Agency. No official endorsement
should be inferred, as the EPA does not endorse the purchase or sale of
any commercial products or services.
NR 40
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U1 1
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1364-5072
EI 1365-2672
J9 J APPL MICROBIOL
JI J. Appl. Microbiol.
PD DEC
PY 2014
VL 117
IS 6
BP 1634
EP 1644
DI 10.1111/jam.12648
PG 11
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AU3JZ
UT WOS:000345510300010
PM 25220421
ER
PT J
AU Omernik, JM
Griffith, GE
AF Omernik, James M.
Griffith, Glenn E.
TI Ecoregions of the Conterminous United States: Evolution of a
Hierarchical Spatial Framework
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Ecoregions; Spatial frameworks; Ecosystem management; Regionalization;
United States; North America
ID LAND-COVER CHANGE; WATER-QUALITY MANAGEMENT; ECOLOGICAL REGIONS;
ECOSYSTEM MANAGEMENT; GREAT-PLAINS; USA; ECOREGIONALIZATION;
CLASSIFICATION; PERSPECTIVES; DELINEATION
AB A map of ecological regions of the conterminous United States, first published in 1987, has been greatly refined and expanded into a hierarchical spatial framework in response to user needs, particularly by state resource management agencies. In collaboration with scientists and resource managers from numerous agencies and institutions in the United States, Mexico, and Canada, the framework has been expanded to cover North America, and the original ecoregions (now termed Level III) have been refined, subdivided, and aggregated to identify coarser as well as more detailed spatial units. The most generalized units (Level I) define 10 ecoregions in the conterminous U.S., while the finest-scale units (Level IV) identify 967 ecoregions. In this paper, we explain the logic underpinning the approach, discuss the evolution of the regional mapping process, and provide examples of how the ecoregions were distinguished at each hierarchical level. The variety of applications of the ecoregion framework illustrates its utility in resource assessment and management.
C1 [Omernik, James M.; Griffith, Glenn E.] US EPA, US Geol Survey, Corvallis, OR 97333 USA.
RP Griffith, GE (reprint author), US EPA, US Geol Survey, 200 SW 35th St, Corvallis, OR 97333 USA.
EM omernik.james@epa.gov; ggriffith@usgs.gov
NR 112
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U1 6
U2 52
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD DEC
PY 2014
VL 54
IS 6
BP 1249
EP 1266
DI 10.1007/s00267-014-0364-1
PG 18
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AT7EN
UT WOS:000345099900002
PM 25223620
ER
PT J
AU Clark, BW
Bone, AJ
Di Giulio, RT
AF Clark, Bryan W.
Bone, A. J.
Di Giulio, R. T.
TI Resistance to teratogenesis by F1 and F2 embryos of PAH-adapted Fundulus
heteroclitus is strongly inherited despite reduced recalcitrance of the
AHR pathway
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Fundulus heteroclitus; Aryl hydrocarbon pathway; Polycyclic aromatic
hydrocarbons; Pollution adaptation; Cardiac teratogenesis
ID POLYCYCLIC AROMATIC-HYDROCARBONS; CREOSOTE-CONTAMINATED SITE;
DEVELOPMENTAL TOXICITY; ATLANTIC KILLIFISH; ELIZABETH RIVER; ALTERED
EXPRESSION; RECEPTOR AGONISTS; SUPERFUND SITE; IN-VITRO; FISH
AB Atlantic killifish (Fundulus heteroclitus) inhabiting the Atlantic Wood Superfund site on the Elizabeth River (Portsmouth, VA, USA) are exposed to a complex mixture of polycyclic aromatic hydrocarbons (PAHs) from former creosote operations, but are resistant to the acute toxicity and cardiac teratogenesis caused by PAHs. The resistance is associated with a dramatic recalcitrance to induction of cytochrome P450 (CYP1) metabolism enzymes following exposure to aryl hydrocarbon receptor (AHR) agonists, along with an elevated antioxidant response and increased expression of several other xenobiotic metabolism and excretion enzymes. However, the heritability of the resistance in the absence of chemical stressors has been inconsistently demonstrated. Understanding the heritability of this resistance will help clarify the nature of population-level responses to chronic exposure to PAH mixtures and aid in identifying the important mechanistic components of resistance to aryl hydrocarbons. We compared the response of Atlantic Wood F1 and F2 embryos to benzo[k]fluoranthene (BkF), benzo[a]pyrene (BaP), 3,3',4,4',5-pentachlorobiphenyl (PCB-126), and a mixture of BkF and fluoranthene (Fl) to that of F1 embryos of reference site killifish. Resistance to cardiac teratogenesis and induction of CYP mRNA expression and CYP activity was determined. We found that both Atlantic Wood F1 and F2 embryos were highly resistance to cardiac teratogenesis. However, the resistance by Atlantic Wood F2 embryos to induction of CYP mRNA expression and enzyme activity was intermediate between that of Atlantic Wood F1 embryos and reference embryos. These results suggest that resistance to cardiac teratogenesis in Atlantic Wood fish is conferred by multiple factors, not all of which appear to be fully genetically heritable.
C1 [Clark, Bryan W.; Bone, A. J.; Di Giulio, R. T.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA.
RP Clark, BW (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
EM bwclark8@gmail.com
OI Bone, Audrey/0000-0002-8853-0553
FU National Institute of Environmental Health [P42ES10356]; Duke University
Integrated Toxicology Program [T32ES007031]
FX We thank Dr. Cole Matson, Dr. Lauren Wills, Dr. Dawoon Jung, Dr. Lindsey
Garner, and Daniel Brown for their assistance with fish collection and
exposure. This work was supported by the National Institute of
Environmental Health supported Superfund Research Program (P42ES10356)
and Duke University Integrated Toxicology Program (T32ES007031).
NR 46
TC 7
Z9 7
U1 2
U2 25
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD DEC
PY 2014
VL 21
IS 24
BP 13898
EP 13908
DI 10.1007/s11356-013-2446-7
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AU0LN
UT WOS:000345314500018
PM 24374617
ER
PT J
AU Yuan, LL
Pollard, AI
AF Yuan, Lester L.
Pollard, Amina I.
TI Classifying lakes to improve precision of nutrient-chlorophyll
relationships
SO FRESHWATER SCIENCE
LA English
DT Article
DE stressor-response; nutrients; chlorophyll; classification
ID CONTERMINOUS UNITED-STATES; MODEL SEARCH; FRESH-WATER; PHOSPHORUS;
EUTROPHICATION; CLASSIFICATION; ECOSYSTEMS; NITROGEN; TREES; TEMPERATURE
AB Accurate and precise estimates of relationships between stressors and environmental responses can inform management decisions most usefully when models can be easily interpreted. Here, we describe an approach for classifying lakes and reservoirs that can improve estimates of the relationships between total P (TP) and chlorophyll a (chl a) concentration, while preserving a model that can be readily interpreted by environmental managers and stakeholders. We selected classification variables statistically with a classification and regression tree in which relationships between TP and chl a were the terminal nodes of the tree. We developed a set of classification trees from bootstrapped replicates of the calibration data to explore a broader range of possible trees. We chose a final tree based on its predictive performance with a validation data set. The total N:TP mass ratio was the classification variable selected most frequently from a broad array of biological, chemical, and physical candidate classification variables. Relationships between TP and chl a in the resulting lake classes provided predictions that were substantially more accurate than predictions computed using nutrient ecoregions based on aggregations of Omernik Level III ecoregions, but predictions from a random forest model that averaged an ensemble of trees were even more accurate. Thus, the classification approach presented here sacrifices a small amount of predictive accuracy to retain a tree structure that is readily interpretable.
C1 [Yuan, Lester L.; Pollard, Amina I.] US EPA, Off Water, Washington, DC 20460 USA.
RP Yuan, LL (reprint author), US EPA, Off Water, 1200 Penn Ave,Mail Code 4304T, Washington, DC 20460 USA.
EM yuan.lester@epa.gov; pollard.amina@epa.gov
NR 54
TC 4
Z9 4
U1 4
U2 37
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 2161-9549
EI 2161-9565
J9 FRESHW SCI
JI Freshw. Sci.
PD DEC
PY 2014
VL 33
IS 4
BP 1184
EP 1194
DI 10.1086/678465
PG 11
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AT4PH
UT WOS:000344922000016
ER
PT J
AU Mackie, JA
Wostenberg, D
Doan, M
Craig, SF
Darling, JA
AF Mackie, Joshua A.
Wostenberg, Darren
Doan, Michael
Craig, Sean F.
Darling, John A.
TI High-throughput Illumina sequencing and microsatellite design in
Watersipora (Bryozoa), a complex of invasive species
SO CONSERVATION GENETICS RESOURCES
LA English
DT Article
DE De novo sequencing; Non-indigenous species; Marine fouling organism
AB The bryozoan genus Watersipora includes rapidly invading species that are becoming common globally. We used paired-end Illumina sequencing to identify thousands of potentially amplifiable microsatellite loci, enabling researchers to track patterns of the invasive spread, and to facilitate ecological and evolutionary question setting. We describe variability of nine loci within recently introduced populations of two Watersipora species in California.
C1 [Mackie, Joshua A.; Wostenberg, Darren] San Jose State Univ, San Jose, CA 95192 USA.
[Doan, Michael] ThermoFisher Sci, San Francisco, CA USA.
[Craig, Sean F.] Humboldt State Univ, Arcata, CA 95521 USA.
[Darling, John A.] US EPA, Durham, NC USA.
RP Mackie, JA (reprint author), San Jose State Univ, San Jose, CA 95192 USA.
EM joshuamackie@gmail.com
FU National Science Foundation [DBI-0959894]
FX Leslee Parr (SJSU), Frank Cipriano (San Francisco State University
Genomics/Transcriptomics Analysis Core), Robert Macey (Profile
Genomics), Dustin DeMeo (Profile Genomics, SJSU), Maria Bangal (SJSU),
Cerise Chen (California Academy of Sciences), Reggie Blackwell (HSU),
Jonathan Geller (Moss Landing Marine Laboratory), Steve Lonhart (South
West Fisheries Science Center, NOAA), Alexander Poole (University of
Colorado School of Medicine), Louise McKenzie (University of NSW), and
the Data Intensive Academic Grid (DIAG) support staff (University of
Maryland Institute for Genome Sciences) provided assistance or
resources. Computation was conducted on the National Science Foundation
funded MRI-R2 project #DBI-0959894. Though this study has been subjected
to US EPA administrative review and approved for publication, its
content does not necessarily reflect official Agency policy.
NR 5
TC 1
Z9 1
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1877-7252
EI 1877-7260
J9 CONSERV GENET RESOUR
JI Conserv. Genet. Resour.
PD DEC
PY 2014
VL 6
IS 4
BP 1053
EP 1055
DI 10.1007/s12686-014-0286-5
PG 3
WC Biodiversity Conservation; Genetics & Heredity
SC Biodiversity & Conservation; Genetics & Heredity
GA AS8EC
UT WOS:000344481900063
ER
PT J
AU Gabriel, M
Knightes, C
Dennis, R
Cooter, E
AF Gabriel, Mark
Knightes, Chris
Dennis, Robin
Cooter, Ellen
TI Potential Impact of Clean Air Act Regulations on Nitrogen Fate and
Transport in the Neuse River Basin: a Modeling Investigation Using CMAQ
and SWAT
SO ENVIRONMENTAL MODELING & ASSESSMENT
LA English
DT Article
DE SWAT model; CMAQ model; Clean Air Act; Nitrogen; Watershed
ID NEW-YORK-STATE; NORTHEASTERN USA; UNITED-STATES; EASTERN USA;
FRESH-WATER; PHASE-I; DEPOSITION; ECOSYSTEMS; AMENDMENTS; EMISSIONS
AB There has been extensive analysis of Clean Air Act Amendment (CAAA) regulation impacts to changes in atmospheric nitrogen deposition; however, few studies have focused on watershed nitrogen transfer particularly regarding long-term predictions. In this study, we investigated impacts of CAAA NOx emissions on the fate and transport of nitrogen for two watersheds in the Neuse River Basin. We applied the Soil and Water Assessment Tool (SWAT) using simulated deposition rates from the Community Multiscale Air Quality (CMAQ) model. Two scenarios were investigated: one that considered CAAA emission controls in CMAQ simulation (with) and a second that did not (without). By 2020, results showed a 70 % drop in nitrogen discharge for the Little River watershed and a 50 % drop for the Nahunta watershed from 1990 levels under the with-CAAA scenario. Denitrification and plant nitrogen uptake played important roles in nitrogen discharge from each watershed. Nitrogen watershed response time to a change in atmospheric nitrogen deposition was 4 years for Nahunta and 2 years for Little River. We attribute these differences in nitrogen response time to contrasts in agricultural land use and diversity of crop types. Soybean, hay, and corn land covers had comparatively longer response times to changes in atmospheric deposition. The studied watersheds demonstrate relatively large nitrogen retention: >= 80 % of all delivered nitrogen.
C1 [Gabriel, Mark; Knightes, Chris] US EPA, Natl Exposure Res Lab NERL, Off Res & Dev ORD, Ecosystem Res Div ERD, Athens, GA 30605 USA.
[Dennis, Robin; Cooter, Ellen] US EPA, ORD, NERL, Atmospher Modeling & Anal Div AMAD, Res Triangle Pk, NC 27711 USA.
RP Gabriel, M (reprint author), US EPA, Natl Exposure Res Lab NERL, Off Res & Dev ORD, Ecosystem Res Div ERD, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM marklive02@yahoo.com
NR 39
TC 1
Z9 2
U1 1
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1420-2026
EI 1573-2967
J9 ENVIRON MODEL ASSESS
JI Environ. Model. Assess.
PD DEC
PY 2014
VL 19
IS 6
BP 451
EP 465
DI 10.1007/s10666-014-9410-x
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AT0CI
UT WOS:000344604200001
ER
PT J
AU Pearson, TRH
Brown, S
Sohngen, B
Henman, J
Ohrel, S
AF Pearson, Timothy R. H.
Brown, Sandra
Sohngen, Brent
Henman, Jennifer
Ohrel, Sara
TI Transaction costs for carbon sequestration projects in the tropical
forest sector
SO MITIGATION AND ADAPTATION STRATEGIES FOR GLOBAL CHANGE
LA English
DT Article
DE Climate change; Carbon projects; Forest carbon; Mitigation; Transaction
costs
AB There is general consensus that carbon (C) sequestration projects in forests are a relatively low cost option for mitigating climate change, but most studies on the subject have assumed that transaction costs are negligible. The objectives of the study were to examine transaction costs for forest C sequestration projects and to determine the significance of the costs based on economic analyses. Here we examine four case studies of active C sequestration projects being implemented in tropical countries and developed for the C market. The results from the case studies were then used with a dynamic forest and land use economic model to investigate how transaction costs affect the efficiency and cost of forest C projects globally. In the case studies transaction costs ranged from 0.38 to 27 million US dollars ($0.09 to $7.71/t CO2) or 0.3 to 270 % of anticipated income depending principally on the price of C and project size. The three largest cost categories were insurance (under the voluntary market; 41-89 % of total costs), monitoring (3-42 %) and regulatory approval (8-50 %). The global analysis indicated that most existing estimates of marginal costs of C sequestration are underestimated by up to 30 % because transaction costs were not included.
C1 [Pearson, Timothy R. H.; Brown, Sandra] Winrock Int Livestock Res & Training Ctr, Arlington, VA 22202 USA.
[Sohngen, Brent] Ohio State Univ, Columbus, OH USA.
[Henman, Jennifer] Climate Adapt Ltd, London, England.
[Ohrel, Sara] US EPA, Washington, DC 20460 USA.
RP Pearson, TRH (reprint author), Winrock Int Livestock Res & Training Ctr, 2121 Crystal Dr,Suite 500, Arlington, VA 22202 USA.
EM tpearson@winrock.org
FU U.S. Environmental Protection Agency
FX This paper was prepared with funding from the U.S. Environmental
Protection Agency. The opinions expressed in the report, however, are
the authors' and do not reflect, necessarily, the views of the EPA. We
express our great thanks to U.S. EPA Work Assignment Managers and to
Heidi Ries of Stratus Consulting, Inc. We also acknowledge the
assistance and generous provision of data from the anonymous case study
projects.
NR 15
TC 3
Z9 5
U1 1
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1381-2386
EI 1573-1596
J9 MITIG ADAPT STRAT GL
JI Mitig. Adapt. Strateg. Glob. Chang.
PD DEC
PY 2014
VL 19
IS 8
BP 1209
EP 1222
DI 10.1007/s11027-013-9469-8
PG 14
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AT2YQ
UT WOS:000344801000006
ER
PT J
AU Soller, JA
Schoen, ME
Varghese, A
Ichida, AM
Boehm, AB
Eftim, S
Ashbolt, NJ
Ravenscroft, JE
AF Soller, Jeffrey A.
Schoen, Mary E.
Varghese, Arun
Ichida, Audrey M.
Boehm, Alexandria B.
Eftim, Sorina
Ashbolt, Nicholas J.
Ravenscroft, John E.
TI Human health risk implications of multiple sources of faecal indicator
bacteria in a recreational waterbody
SO WATER RESEARCH
LA English
DT Article
DE Recreational water; Quantitative microbial risk assessment; Microbial
source apportionment; Faecal contamination
ID 16S RIBOSOMAL-RNA; RAPIDLY MEASURED INDICATORS; DOSE-RESPONSE;
GASTROINTESTINAL ILLNESS; CAMPYLOBACTER-JEJUNI; UNITED-STATES; MARINE
WATER; QUALITY; EXPOSURE; MARKERS
AB We simulate the influence of multiple sources of enterococci (ENT) as faecal indicator bacteria (FIB) in recreational water bodies on potential human health risk by considering waters impacted by human and animal sources, human and non-pathogenic sources, and animal and non-pathogenic sources. We illustrate that risks vary with the proportion of culturable ENT in water bodies derived from these sources and estimate corresponding ENT densities that yield the same level of health protection that the recreational water quality criteria in the United States seeks (benchmark risk). The benchmark risk is based on epidemiological studies conducted in water bodies predominantly impacted by human faecal sources. The key result is that the risks from mixed sources are driven predominantly by the proportion of the contamination source with the greatest ability to cause human infection (potency), not necessarily the greatest source(s) of FIB. Predicted risks from exposures to mixtures comprised of approximately 30% ENT from human sources were up to 50% lower than the risks expected from purely human sources when contamination is recent and ENT levels are at the current water quality criteria levels (35 CPU 100 mL(-1)). For human/non-pathogenic, human/gull, human/pig, and human/chicken faecal mixtures with relatively low human contribution, the predicted culturable enterococci densities that correspond to the benchmark risk are substantially greater than the current water quality criteria values. These findings are important because they highlight the potential applicability of site specific water quality criteria for waters that are predominantly un-impacted by human sources. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Soller, Jeffrey A.; Schoen, Mary E.] Soller Environm LLC, Berkeley, CA 94703 USA.
[Varghese, Arun; Ichida, Audrey M.; Eftim, Sorina] ICF Int LLC, Fairfax, VA 22031 USA.
[Boehm, Alexandria B.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
[Ashbolt, Nicholas J.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Ravenscroft, John E.] US EPA, Off Water, Off Sci & Technol, Washington, DC 20460 USA.
RP Soller, JA (reprint author), Soller Environm LLC, 3022 King St, Berkeley, CA 94703 USA.
EM jsoller@sollerenvironmental.com
OI Ravenscroft, John/0000-0002-8834-7310
FU U.S. EPA Office of Water, Office of Science and Technology
FX The research described in this article was funded by the U.S. EPA Office
of Water, Office of Science and Technology. This work has been subject
to formal Agency review, but does not necessarily reflect the views of
the Agency, and no official endorsement should be inferred. We are
grateful to Tim Bartrand for conducting the literature review for animal
sources, Martha Embrey, Elizabeth Doyle, and Betsy Behl for providing
invaluable review and technical edit of our draft manuscript, and Orin
Shanks for insightful comments.
NR 70
TC 18
Z9 18
U1 7
U2 43
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD DEC 1
PY 2014
VL 66
BP 254
EP 264
DI 10.1016/j.watres.2014.08.026
PG 11
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AT3GI
UT WOS:000344823500024
PM 25222329
ER
PT J
AU Procter, AC
Ellis, JC
Fay, PA
Polley, HW
Jackson, RB
AF Procter, Andrew C.
Ellis, J. Christopher
Fay, Philip A.
Polley, H. Wayne
Jackson, Robert B.
TI Fungal Community Responses to Past and Future Atmospheric CO2 Differ by
Soil Type
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID ARBUSCULAR MYCORRHIZAL FUNGI; CARBON-DIOXIDE; FOREST SOILS; ELEVATED
CO2; GRASSLAND PRODUCTIVITY; TALLGRASS PRAIRIE; DIVERSITY; PLANT;
NITROGEN; ECOSYSTEM
AB Soils sequester and release substantial atmospheric carbon, but the contribution of fungal communities to soil carbon balance under rising CO2 is not well understood. Soil properties likely mediate these fungal responses but are rarely explored in CO2 experiments. We studied soil fungal communities in a grassland ecosystem exposed to a preindustrial-to-future CO2 gradient ( 250 to 500 ppm) in a black clay soil and a sandy loam soil. Sanger sequencing and pyrosequencing of the rRNA gene cluster revealed that fungal community composition and its response to CO2 differed significantly between soils. Fungal species richness and relative abundance of Chytridiomycota ( chytrids) increased linearly with CO2 in the black clay ( P < 0.04, R-2 > 0.7), whereas the relative abundance of Glomeromycota ( arbuscular mycorrhizal fungi) increased linearly with elevated CO2 in the sandy loam ( P = 0.02, R-2 = 0.63). Across both soils, decomposition rate was positively correlated with chytrid relative abundance ( r = 0.57) and, in the black clay soil, fungal species richness. Decomposition rate was more strongly correlated with microbial biomass ( r = 0.88) than with fungal variables. Increased labile carbon availability with elevated CO2 may explain the greater fungal species richness and Chytridiomycota abundance in the black clay soil, whereas increased phosphorus limitation may explain the increase in Glomeromycota at elevated O-2 in the sandy loam. Our results demonstrate that soil type plays a key role in soil fungal responses to rising atmospheric CO2.
C1 [Procter, Andrew C.; Ellis, J. Christopher; Jackson, Robert B.] Duke Univ, Dept Biol, Durham, NC USA.
[Fay, Philip A.; Polley, H. Wayne] ARS, Grassland Soil & Water Res Lab, USDA, Temple, TX USA.
[Jackson, Robert B.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA.
[Jackson, Robert B.] Stanford Univ, Sch Earth Sci, Stanford, CA 94305 USA.
RP Procter, AC (reprint author), US EPA, Res Triangle Pk, NC 27711 USA.
EM acprocter@gmail.com
OI Fay, Philip/0000-0002-8291-6316
FU U. S. Department of Energy (Program in Ecosystem Research) [ER64242]; U.
S. Department of Agriculture; Sigma Xi; National Science Foundation
FX This project was supported by funding from the U. S. Department of
Energy (Program in Ecosystem Research no. ER64242), the U. S. Department
of Agriculture, Sigma Xi, and the National Science Foundation.
NR 71
TC 8
Z9 8
U1 3
U2 50
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD DEC
PY 2014
VL 80
IS 23
BP 7364
EP 7377
DI 10.1128/AEM.02083-14
PG 14
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AS3FW
UT WOS:000344163700027
PM 25239904
ER
PT J
AU Johansson, E
Reponen, T
Meller, J
Vesper, S
Yadav, J
AF Johansson, Elisabet
Reponen, Tiina
Meller, Jarek
Vesper, Stephen
Yadav, Jagjit
TI Association of Streptomyces community composition determined by
PCR-denaturing gradient gel electrophoresis with indoor mold status
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Streptomyces; Denaturing gradient gel electrophoresis; House dust; Mold;
Decision trees
ID DAMAGED BUILDING-MATERIALS; RELATIVE MOLDINESS INDEX;
STACHYBOTRYS-CHARTARUM; QUANTITATIVE PCR; HOUSE-DUST; CALIFORNICUS;
HOMES; EXPOSURE; ASTHMA; AIR
AB Both Streptomyces species and mold species have previously been isolated from moisture-damaged building materials; however, an association between these two groups of microorganisms in indoor environments is not clear. In this study, we used a culture-independent method, PCR-denaturing gradient gel electrophoresis (PCR-DGGE), to investigate the composition of the Streptomyces community in house dust. Twenty-three dust samples each from two sets of homes categorized as high-mold and low-mold based on mold-specific quantitative PCR analysis were used in the study. Taxonomic identification of prominent bands was performed by cloning and sequencing. Associations between DGGE amplicon band intensities and home mold status were assessed using univariate analyses as well as multivariate recursive partitioning (decision trees) to test the predictive value of combinations of bands intensities. In the final classification tree, a combination of two bands was significantly associated with mold status of the home (p = 0.001). The sequence corresponding to one of the bands in the final decision tree matched a group of Streptomyces species that included Streptomyces coelicolor and Streptomyces sampsonii, both of which have been isolated from moisture-damaged buildings previously. The closest match for the majority of sequences corresponding to a second band consisted of a group of Streptomyces species that included Streptomyces hygroscopicus, an important producer of antibiotics and immunosuppressors. Taken together, the study showed that DGGE can be a useful tool for identifying bacterial species that may be more prevalent in mold-damaged buildings.
C1 [Johansson, Elisabet; Reponen, Tiina; Meller, Jarek; Yadav, Jagjit] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA.
[Vesper, Stephen] US EPA, Cincinnati, OH 45268 USA.
RP Johansson, E (reprint author), Cincinnati Childrens Hosp, Dept Pediat, 3333 Burnet Ave,ML 7037, Cincinnati, OH 45229 USA.
EM Hanna.Johansson@cchmc.org
FU National Institute for Occupational Safety and Health Pilot Research
Project Training Program of the University of Cincinnati Education and
Research Center [T42/OH008432-05]; National Institute of Environmental
Health Sciences [ES10957, ES11170]; US Department of Housing and Urban
Development [OHLHH0162-07]
FX This study was partially supported by National Institute for
Occupational Safety and Health Pilot Research Project Training Program
of the University of Cincinnati Education and Research Center Grant
#T42/OH008432-05. Additional funding came from the National Institute of
Environmental Health Sciences grants ES10957 and ES11170. The home
assessment was supported by the US Department of Housing and Urban
Development grant #OHLHH0162-07. The authors would like to thank Dr
Renuka Na and Dr Suman Pradhan for advice and assistance with the DGGE
method.
NR 35
TC 1
Z9 1
U1 0
U2 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
EI 1573-2959
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD DEC
PY 2014
VL 186
IS 12
BP 8773
EP 8783
DI 10.1007/s10661-014-4071-4
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AS6BF
UT WOS:000344349200052
PM 25331035
ER
PT J
AU Seifert-Monson, LR
Hill, BH
Kolka, RK
Jicha, TM
Lehto, LL
Elonen, CM
AF Seifert-Monson, L. R.
Hill, B. H.
Kolka, R. K.
Jicha, T. M.
Lehto, L. L.
Elonen, C. M.
TI Effects of sulfate deposition on pore water dissolved organic carbon,
nutrients, and microbial enzyme activities in a northern peatland
SO SOIL BIOLOGY & BIOCHEMISTRY
LA English
DT Article
DE Atmospheric deposition; Dissolved organic carbon; Peatland; Phosphorus;
Microbial enzyme activity
ID RIVERINE BACTERIOPLANKTON; SURFACE WATERS; CLIMATE-CHANGE; SOILS;
EXPORT; EUTROPHICATION; STOICHIOMETRY; DECOMPOSITION; SUBSTANCES;
ECOSYSTEMS
AB Export of dissolved organic carbon from lakes and streams has increased throughout Europe and North America over the past several decades. One possible cause is altered deposition chemistry; specifically, decreasing sulfate inputs leading to changes in ionic strength and dissolved organic carbon solubility. To further investigate the relationship between deposition chemistry and dissolved organic carbon export in peatlands, a field experiment was conducted to compare the pore water chemistry and peat microbial enzyme activity of mesocosms receiving sulfate amendments to mesocosms receiving no additions. To consider how peatlands respond during recovery from increased inputs of sulfate, samples were also analyzed from an area of the same peatland that was previously amended with sulfate. Current additions of sulfate decreased dissolved organic carbon concentration and increased dissolved organic carbon aromaticity. Total dissolved phosphorus decreased in response to current sulfate amendments but was elevated in the area of the peatland recovering from sulfate amendment. The total dissolved phosphorus increase, which was reflected in microbial enzyme activity, may have shifted the system from P limitation to N limitation. This shift could have important consequences for ecosystem processes related to plant and microbial communities. It also suggests that the recovery from previous sulfate amendments may take longer than may be expected. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Seifert-Monson, L. R.] Univ Minnesota, Integrated Biosci Grad Program, Duluth, MN 55812 USA.
[Hill, B. H.; Jicha, T. M.; Lehto, L. L.; Elonen, C. M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55894 USA.
[Kolka, R. K.] US Forest Serv, No Res Stn, Ctr Res Ecosyst Change, Grand Rapids, MN 55744 USA.
RP Seifert-Monson, LR (reprint author), 1411 North Rd, Duluth, MN 55811 USA.
EM seif0073@d.umn.edu
FU University of Minnesota-U.S. Environmental Protection Agency Cooperative
training partnership [CR83492801]
FX The authors would like to thank researchers at the Northern Research
Station of the USDA Forest service, including Deacon Kyllander, Carrie
Dorrance and Dr. Stephen Sebestyen, who provided general assistance,
watershed data, and information on trends of dissolved organic matter
export. Thanks to Dr. John Pastor and Dr. Josef Werne for advice on
study design and previous versions of this manuscript. This research was
funded through the University of Minnesota-U.S. Environmental Protection
Agency Cooperative training partnership (CR83492801).
NR 39
TC 3
Z9 3
U1 4
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0038-0717
J9 SOIL BIOL BIOCHEM
JI Soil Biol. Biochem.
PD DEC
PY 2014
VL 79
BP 91
EP 99
DI 10.1016/j.soilbio.2014.09.007
PG 9
WC Soil Science
SC Agriculture
GA AS7HX
UT WOS:000344428600012
ER
PT J
AU Garcia-Alonso, M
Hendley, P
Bigler, F
Mayeregger, E
Parker, R
Rubinstein, C
Satorre, E
Solari, F
McLean, M
AF Garcia-Alonso, Monica
Hendley, Paul
Bigler, Franz
Mayeregger, Edgar
Parker, Ronald
Rubinstein, Clara
Satorre, Emilio
Solari, Fernando
McLean, Morven A.
TI Transportability of confined field trial data for environmental risk
assessment of genetically engineered plants: a conceptual framework
SO TRANSGENIC RESEARCH
LA English
DT Article
DE Genetically engineered plant; Confined field trial; Regulatory
framework; Transportability; Agro-climatic zone
ID TRANSGENIC CROPS; YIELD; MANAGEMENT; WORLD
AB It is commonly held that confined field trials (CFTs) used to evaluate the potential adverse environmental impacts of a genetically engineered (GE) plant should be conducted in each country where cultivation is intended, even when relevant and potentially sufficient data are already available from studies conducted elsewhere. The acceptance of data generated in CFTs "out of country" can only be realized in practice if the agro-climatic zone where a CFT is conducted is demonstrably representative of the agro-climatic zones in those geographies to which the data will be transported. In an attempt to elaborate this idea, a multi-disciplinary Working Group of scientists collaborated to develop a conceptual framework and associated process that can be used by the regulated and regulatory communities to support transportability of CFT data for environmental risk assessment (ERA). As proposed here, application of the conceptual framework provides a scientifically defensible process for evaluating if existing CFT data from remote sites are relevant and/or sufficient for local ERAs. Additionally, it promotes a strategic approach to identifying CFT site locations so that field data will be transportable from one regulatory jurisdiction to another. Application of the framework and process should be particularly beneficial to public sector product developers and small enterprises that develop innovative GE events but cannot afford to replicate redundant CFTs, and to regulatory authorities seeking to improve the deployment of limited institutional resources.
C1 [Garcia-Alonso, Monica] Estel Consult Ltd, Binfield RG42 4HG, Berks, England.
[Hendley, Paul] Phasera Ltd, Bracknell RG12 2JJ, Berks, England.
[Bigler, Franz] Agroscope Reckenholz Tanikon, CH-8046 Zurich, Switzerland.
[Mayeregger, Edgar] Minist Agr, Unidad Gest Riesgo, Asuncion, Paraguay.
[Parker, Ronald] US EPA, Off Pesticide Programs, Environm Fate & Effects Div, Arlington, VA 22202 USA.
[Rubinstein, Clara] ILSI Argentina, Buenos Aires, DF, Argentina.
[Satorre, Emilio] Univ Buenos Aires, Fac Agron & Vet, Catedra Cerealicultura, IFEVA, Buenos Aires, DF, Argentina.
[Solari, Fernando] Monsanto Argentina SAIC, Estn Expt Fontezuela, Buenos Aires, DF, Argentina.
[McLean, Morven A.] ILSI Res Fdn, Ctr Environm Risk Assessment, Washington, DC 20005 USA.
RP McLean, M (reprint author), ILSI Res Fdn, Ctr Environm Risk Assessment, 1156 Fifteenth St NW,Suite 200, Washington, DC 20005 USA.
EM mmclean@ilsi.org
FU United States Department of Agriculture Emerging Markets Program
FX Funding in support of this project was provided by the United States
Department of Agriculture Emerging Markets Program Grant 2010-2040.
NR 64
TC 6
Z9 6
U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-8819
EI 1573-9368
J9 TRANSGENIC RES
JI Transgenic Res.
PD DEC
PY 2014
VL 23
IS 6
BP 1025
EP 1041
DI 10.1007/s11248-014-9785-0
PG 17
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA AS3EH
UT WOS:000344158800011
PM 24733670
ER
PT J
AU Conmy, RN
AF Conmy, Robyn N.
TI Robyn N. Conmy
SO OCEANOGRAPHY
LA English
DT Biographical-Item
C1 [Conmy, Robyn N.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Conmy, RN (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM conmy.robyn@epa.gov
NR 1
TC 0
Z9 0
U1 0
U2 0
PU OCEANOGRAPHY SOC
PI ROCKVILLE
PA P.O. BOX 1931, ROCKVILLE, MD USA
SN 1042-8275
J9 OCEANOGRAPHY
JI Oceanography
PD DEC
PY 2014
VL 27
IS 4
SU S
BP 87
EP 87
PG 1
WC Oceanography
SC Oceanography
GA V44BO
UT WOS:000209724700048
ER
PT J
AU Bradman, A
Castorina, R
Gaspar, F
Nishioka, M
Colon, M
Weathers, W
Egeghy, PP
Maddalena, R
Williams, J
Jenkins, PL
McKone, TE
AF Bradman, Asa
Castorina, Rosemary
Gaspar, Fraser
Nishioka, Marcia
Colon, Maribel
Weathers, Walter
Egeghy, Peter P.
Maddalena, Randy
Williams, Jeffery
Jenkins, Peggy L.
McKone, Thomas E.
TI Flame retardant exposures in California early childhood education
environments
SO CHEMOSPHERE
LA English
DT Article
DE Child care; Children; Exposure; Flame retardant; PBDEs
ID POLYBROMINATED DIPHENYL ETHERS; IN-HOUSE DUST; SERUM CONCENTRATIONS;
HORMONE DISRUPTION; THYROID-HORMONE; PHASE-OUT; PBDES; ASSOCIATIONS;
PRODUCTS; SAMPLES
AB Infants and young children spend as much as 50 h per week in child care and preschool. Although approximately 13 million children, or 65% of all U.S. children, spend some time each day in early childhood education (ECE) facilities, little information is available about environmental exposures in these environments. We measured flame retardants in air and dust collected from 40 California ECE facilities between May 2010 and May 2011. Low levels of six polybrominated diphenyl ether (PBDE) congeners and four non-PBDE flame retardants were present in air, including two constituents of Firemaster 550 and two tris phosphate compounds [tris (2-chloroethyl) phosphate (TCEP) and tris (1,3-dichloroisopropyl) phosphate (TDCIPP)]. Tris phosphate, Firemaster 550 and PBDE compounds were detected in 100% of the dust samples. BDE47, BDE99, and BDE209 comprised the majority of the PBDE mass measured in dust. The median concentrations of TCEP (319 ng g(-1)) and TDCIPP (2265 ng g(-1)) were similar to or higher than any PBDE congener. Levels of TCEP and TDCIPP in dust were significantly higher in facilities with napping equipment made out of foam (Mann Whitney p-values < 0.05). Child BDE99 dose estimates exceeded the RID in one facility for children < 3 years old. In 51% of facilities, TDCIPP dose estimates for children < 6 years old exceeded age-specific "No Significant Risk Levels (NSRLs)" based on California Proposition 65 guidelines for carcinogens. Given the overriding interest in providing safe and healthy environments for young children, additional research is needed to identify strategies to reduce indoor sources of flame retardant chemicals. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Bradman, Asa; Castorina, Rosemary; Gaspar, Fraser; McKone, Thomas E.] Univ Calif Berkeley, Sch Publ Hlth, Ctr Environm Res & Childrens Hlth, Berkeley, CA 94704 USA.
[Nishioka, Marcia] Battelle Mem Inst, Columbus, OH 43201 USA.
[Colon, Maribel; Weathers, Walter; Egeghy, Peter P.] US EPA, Res Triangle Pk, NC 27711 USA.
[Maddalena, Randy; McKone, Thomas E.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
[Williams, Jeffery; Jenkins, Peggy L.] Calif Air Resources Board, Sacramento, CA USA.
RP Bradman, A (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Ctr Environm Res & Childrens Hlth, 1995 Univ Ave,Suite 265, Berkeley, CA 94704 USA.
EM abradman@berkeley.edu
OI Gaspar, Fraser/0000-0002-0782-5721
FU California Air Resources Board (ARB) [08-305]
FX This research was funded by the California Air Resources Board (ARB
Contract No. 08-305). This work does not necessarily reflect the opinion
or official policy of the ARB. Although this work was reviewed by U.S.
EPA and approved for publication, it does not necessarily reflect the
opinion or official policy of the U.S. EPA. Co-author Walter Weathers
has recently retired from the U.S. EPA.
NR 44
TC 18
Z9 18
U1 4
U2 61
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD DEC
PY 2014
VL 116
SI SI
BP 61
EP 66
DI 10.1016/j.chemosphere.2014.02.072
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5KH
UT WOS:000343623200010
PM 24835158
ER
PT J
AU Davis, EL
AF Davis, Eva L.
TI Discussion of Paper
SO GROUND WATER MONITORING AND REMEDIATION
LA English
DT Editorial Material
C1 US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74821 USA.
RP Davis, EL (reprint author), US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, POB 1198, Ada, OK 74821 USA.
EM Davis.Eva@epa.gov
NR 7
TC 0
Z9 0
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-3629
EI 1745-6592
J9 GROUND WATER MONIT R
JI Ground Water Monit. Remediat.
PD WIN
PY 2014
VL 34
IS 1
BP 27
EP 28
DI 10.1111/gwmr.12043
PG 2
WC Water Resources
SC Water Resources
GA AB2IU
UT WOS:000331617200017
ER
PT J
AU Loperfido, JV
Noe, GB
Jarnagin, ST
Hogan, DM
AF Loperfido, J. V.
Noe, Gregory B.
Jarnagin, S. Taylor
Hogan, Dianna M.
TI Effects of distributed and centralized stormwater best management
practices and land cover on urban stream hydrology at the catchment
scale
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Stormwater best management practices; Low impact development;
Distributed treatment systems; Urban hydrology; Land cover; Chesapeake
Bay
ID LOW IMPACT DEVELOPMENT; WATER MANAGEMENT; INFILTRATION; BASEFLOW;
RUNOFF; PERFORMANCE
AB Urban stormwater runoff remains an important issue that causes local and regional-scale water quantity and quality issues. Stormwater best management practices (BMPs) have been widely used to mitigate runoff issues, traditionally in a centralized manner; however, problems associated with urban hydrology have remained. An emerging trend is implementation of BMPs in a distributed manner (multi-BMP treatment trains located on the landscape and integrated with urban design), but little catchment-scale performance of these systems have been reported to date. Here, stream hydrologic data (March, 2011September, 2012) are evaluated in four catchments located in the Chesapeake Bay watershed: one utilizing distributed stormwater BMPs, two utilizing centralized stormwater BMPs, and a forested catchment serving as a reference. Among urban catchments with similar land cover, geology and BMP design standards (i.e. 100-year event), but contrasting placement of stormwater BMPs, distributed BMPs resulted in: significantly greater estimated baseflow, a higher minimum precipitation threshold for stream response and maximum discharge increases, better maximum discharge control for small precipitation events, and reduced runoff volume during an extreme (1000-year) precipitation event compared to centralized BMPs. For all catchments, greater forest land cover and less impervious cover appeared to be more important drivers than stormwater BMP spatial pattern, and caused lower total, stormflow, and baseflow runoff volume; lower maximum discharge during typical precipitation events; and lower runoff volume during an extreme precipitation event. Analysis of hydrologic field data in this study suggests that both the spatial distribution of stormwater BMPs and land cover are important for management of urban stormwater runoff. In particular, catchment-wide application of distributed BMPs improved stream hydrology compared to centralized BMPs, but not enough to fully replicate forested catchment stream hydrology. Integrated planning of stormwater management, protected riparian buffers and forest land cover with suburban development in the distributed-BMP catchment enabled multi-purpose use of land that provided esthetic value and green-space, community gathering points, and wildlife habitat in addition to hydrologic stormwater treatment. Published by Elsevier B.V.
C1 [Loperfido, J. V.; Hogan, Dianna M.] US Geol Survey, Eastern Geog Sci Ctr, Reston, VA 20192 USA.
[Noe, Gregory B.] US Geol Survey, Natl Res Program, Reston, VA 20192 USA.
[Jarnagin, S. Taylor] US Environm Protect Agcy, ORD NERL ESD, Landscape Ecol Branch, Res Triangle Pk, NC 27711 USA.
RP Loperfido, JV (reprint author), US Geol Survey, Eastern Geog Sci Ctr, 521 Natl Ctr, Reston, VA 20192 USA.
EM jloperfido@usgs.gov; gnoe@usgs.gov; jarnagin.taylor@epa.gov;
dhogan@usgs.gov
OI Noe, Gregory/0000-0002-6661-2646
FU U.S. Geological Survey (USGS); United States Environmental Protection
Agency [DW14921533, DW14921811, DW14922385]; Montgomery County
Department of Environmental Protection; Fairfax County, VA
FX This work was supported by the following U.S. Geological Survey (USGS)
Programs: Mendenhall Research Fellowship Program, Land Change Science,
Chesapeake Priority Ecosystem Studies, and the National Research
Program. The authors appreciate contributions from Keith Van Ness
(Montgomery County Department of Environmental Protection); Annette
Hall, Daniel K. Jones, and Brianna Hammond (USGS Eastern Geographic
Science Center); John Jastram and Ken Hyer (USGS Virginia Water Science
Center); Ed Doheny and Matt Baker (USGS Maryland-DelawareD.C. Water
Science Center); Barry Croke for hydrologic discussions; and reviews
from Bill Selbig, T.A. Endreny, and anonymous reviewers. The United
States Environmental Protection Agency through its Office of Research
and Development collaborated in the research described here. The
manuscript has been subjected to Agency review and approved for
publication. The streamflow data referenced in this document have been
funded in part by the United States Environmental Protection Agency
under assistance agreements DW14921533, DW14921811, and DW14922385 to
the U.S. Geological Survey, Montgomery County Department of
Environmental Protection, and Fairfax County, VA.
NR 45
TC 24
Z9 25
U1 20
U2 92
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
SI SI
BP 2584
EP 2595
DI 10.1016/j.jhydrol.2014.07.007
PN C
PG 12
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5ED
UT WOS:000347595000019
ER
PT J
AU Jiang, Y
Frankenberger, JR
Bowling, LC
Sun, ZN
AF Jiang, Yan
Frankenberger, Jane R.
Bowling, Laura C.
Sun, Zhaonan
TI Quantification of uncertainty in estimated nitrate-N loads in
agricultural watersheds
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Nitrate-N load; Measurement uncertainty; Load calculation uncertainty;
Error propagation
ID ARTIFICIALLY DRAINED CATCHMENTS; LAURENTIAN GREAT-LAKES; RIVER
DISCHARGE; NUTRIENT INPUTS; RATING CURVE; QUALITY DATA; PHOSPHORUS;
NITROGEN; ALGORITHMS; STRATEGIES
AB Estimation of annual nutrient loads is critical for many applications in water quality management; however, measurement errors and infrequent monitoring could raise considerable uncertainty in the load estimations. The objectives of this study were to quantify the overall uncertainty in annual nitrate-N load estimates. Nitrate was selected as the study object because of the high loads common in Midwestern streams, and its important influence on hypoxia in the Gulf of Mexico. A standard error propagation method was used to quantify the uncertainty from both measurement and load calculation processes to evaluate the accumulative effect. The measurement uncertainty was assessed based on standard information; the load calculation uncertainty was evaluated through numerical simulation. The study found that uncertainty in annual nitrate-N load estimates for a 30-day sampling frequency, expressed as coefficient of variation (CV), was 14-34%. This included measurement (flow and concentration) uncertainty of 12% and load calculation uncertainty of 7-32%. These results can be used to evaluate different uncertainty sources, estimate uncertainty for similar watersheds, and design sampling programs balancing cost and accuracy. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Jiang, Yan] US EPA, Las Vegas, NV 89119 USA.
[Frankenberger, Jane R.] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA.
[Bowling, Laura C.] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA.
[Sun, Zhaonan] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA.
RP Jiang, Y (reprint author), US EPA, 944 Harmon Ave, Las Vegas, NV 89119 USA.
EM enaj1125@gmail.com
RI Bowling, Laura/B-6963-2013
OI Bowling, Laura/0000-0002-1439-3154
NR 54
TC 5
Z9 5
U1 1
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 106
EP 116
DI 10.1016/j.jhydrol.2014.06.027
PN A
PG 11
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5BY
UT WOS:000347589500009
ER
PT J
AU Hathaway, JM
Brown, RA
Fu, JS
Hunt, WF
AF Hathaway, J. M.
Brown, R. A.
Fu, J. S.
Hunt, W. F.
TI Bioretention function under climate change scenarios in North Carolina,
USA
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Bioretention; Biofilter; Hydrology; Climate change; Water balance;
DRAINMOD
ID PRECIPITATION EXTREMES; POLLUTANT REMOVAL; IMPACTS; PERFORMANCE;
DRAINAGE; STORMWATER; HYDROLOGY; WATER; MITIGATION; SYSTEMS
AB The effect of climate change on stormwater controls is largely unknown. Evaluating such effects is important for understanding how well resiliency can be built into urban watersheds by implementing these systems. Bioretention areas with varied media depths, in situ soil types, drainage configurations, and surface infiltration capabilities have previously been monitored, modelled, and calibrated using the continuous simulation model, DRAINMOD. In this study, data from downscaled climate projections for 2055 through 2058 were utilized in these models to evaluate changes in system hydrologic function under two climate change scenarios (RCP 4.5 and 8.5). The results were compared to those generated using a "Base" scenario of observed data from 2001 to 2004. The results showed a modest change in the overall water balance of the system. In particular, the frequency and magnitude of overflow from the systems substantially increased under the climate change scenarios. As this represents an increase in the amount of uncontrolled, untreated runoff from the contributing watersheds, it is of particular concern. Further modelling showed that between 9.0 and 31.0 cm of additional storage would be required under the climate change scenarios to restrict annual overflow to that of the base scenario. Bioretention surface storage volume and infiltration rate appeared important in determining a system's ability to cope with increased yearly rainfall and higher rainfall magnitudes. As climate change effects vary based on location, similar studies should be performed in other locations to determine localized effects on stormwater controls. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Hathaway, J. M.; Fu, J. S.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Brown, R. A.] US EPA, Edison, NJ USA.
[Hunt, W. F.] N Carolina State Univ, Dept Biol & Agr Engn, Raleigh, NC 27695 USA.
RP Hathaway, JM (reprint author), Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
EM hathaway@utk.edu
NR 33
TC 5
Z9 5
U1 8
U2 52
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 503
EP 511
DI 10.1016/j.jhydrol.2014.07.037
PN A
PG 9
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5BY
UT WOS:000347589500041
ER
PT J
AU Guber, AK
Pachepsky, YA
Yakirevich, AM
Shelton, DR
Whelan, G
Goodrich, DC
Unkrich, CL
AF Guber, A. K.
Pachepsky, Y. A.
Yakirevich, A. M.
Shelton, D. R.
Whelan, G.
Goodrich, D. C.
Unkrich, C. L.
TI Modeling runoff and microbial overland transport with KINEROS2/STWIR
model: Accuracy and uncertainty as affected by source of infiltration
parameters
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Bacteria; Runoff; Uncertainty; Modeling; Infiltration parameters
ID SOIL-WATER RETENTION; ARTIFICIAL NEURAL-NETWORK; VEGETATIVE FILTER
STRIPS; HYDRAULIC CONDUCTIVITY; PEDOTRANSFER FUNCTIONS; COLIFORM
BACTERIA; BROOKS-COREY; BULK-DENSITY; FLOW; SCALE
AB Infiltration is important to modeling the overland transport of microorganisms in environmental waters. In watershed- and hillslope scale-models, infiltration is commonly described by simple equations relating infiltration rate to soil saturated conductivity and by empirical parameters defining changes in infiltration rate with soil water content. For the microbial transport model KINEROS2/STWIR used in this study, infiltration in unsaturated soil is accounted for by a net capillary drive parameter, G, in the Parlange equation. Scarce experimental data and multiple approaches for estimating parameter G introduce uncertainty, reducing reliability of overland water flow and microbial transport models. Our objectives were to evaluate reliability and robustness of three methods to estimate parameter G and associated accuracy and uncertainty in predicting runoff and fecal coliform (FC) transport. These methods include (i) KINEROS2 fitting to the experimental cumulative runoff data; (ii) estimating solely on soil texture; and (iii) estimating by individual pedotransfer functions (PTFs) and an ensemble of PTFs from basic soil properties. Results show that the most accurate prediction was obtained when the G parameter was fitted to the cumulative runoff. The KINEROS2-recommended parameter slightly overestimated the calibrated value of parameter G and yielded less accurate predictions of runoff, FC concentrations and total FC. The PTFs-estimated parameters systematically deviated from calibrated G values that caused high uncertainty in the KINEROS2/STWIR predictions. Averaging PTF estimates considerably improved model accuracy, reducing the uncertainty of runoff and FC concentration predictions. Overall, ensemble-based PTF estimation of the capillary drive can be efficient for simulations of runoff and bacteria overland transport when a single effective value is used across the study area. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Guber, A. K.] Michigan State Univ, Dept Plant Soil & Microbial Sci, E Lansing, MI 48824 USA.
[Pachepsky, Y. A.; Shelton, D. R.] USDA ARS, Environm Microbial & Food Safety Lab, Beltsville, MD 20705 USA.
[Yakirevich, A. M.] Ben Gurion Univ Negev, Zuckerberg Inst Water Res, J Blaustein Inst Desert Res, IL-84990 Sede Boqer, Israel.
[Whelan, G.] US EPA, Athens, GA 30605 USA.
[Goodrich, D. C.; Unkrich, C. L.] USDA ARS, Southwest Watershed Res Ctr, Tucson, AZ 85719 USA.
RP Guber, AK (reprint author), Michigan State Univ, Dept Plant Soil & Microbial Sci, 1066 Bogue St,Room 584D, E Lansing, MI 48824 USA.
EM Akguber@msu.edu; yakov.pachepsky@ars.usda.gov; alexy@bgu.ac.il;
whelan.gene@epa.gov; dave.goodrich@ars.usda.gov
OI Pachepsky, Yakov/0000-0003-0232-6090
NR 72
TC 4
Z9 5
U1 0
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 644
EP 655
DI 10.1016/j.jhydrol.2014.08.005
PN A
PG 12
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AY5BY
UT WOS:000347589500053
ER
PT J
AU Wang, DJ
Su, CM
Zhang, W
Hao, XZ
Cang, L
Wang, YJ
Zhou, DM
AF Wang, Dengjun
Su, Chunming
Zhang, Wei
Hao, Xiuzhen
Cang, Long
Wang, Yujun
Zhou, Dongmei
TI Laboratory assessment of the mobility of water-dispersed engineered
nanoparticles in a red soil (Ultisol)
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Engineered nanoparticle; Red soil; Ultisol; Transport; Modeling; Porous
media
ID HETEROGENEOUS POROUS-MEDIA; LABELED HYDROXYAPATITE NANOPARTICLES;
STABILIZED SILVER NANOPARTICLES; WALLED CARBON NANOTUBES; COLLOID
TRANSPORT; NATURAL SOILS; FULLERENE NANOPARTICLES; FACILITATED
TRANSPORT; PREFERENTIAL FLOW; SURFACE-CHARGE
AB Soils are major sinks of engineered nanoparticles (ENPs) as results of land applications of sewage sludge, accidental spills, or deliberate applications of ENPs (e.g., nano-pesticides). In this study, the transport behaviors of four widely used ENPs (i.e., titanium dioxide [TiO2], buckminsterfullerene [C-60], single-walled carbon nanotube [SWNT], and elemental silver [Ag-0]) were investigated in water-saturated columns packed with either a quartz sand, a red soil (Ultisol), or sand/soil mixtures with soil mass fraction (lambda) from 0% to 100% at slightly acidic solution pH (4.0-5.0). The mobility of tested ENPs decreased significantly with increasing lambda, which was attributed to increased surface area and/or retention sites imparted by iron oxides, clay minerals, and organic matter in the red soil. Breakthrough curves of all ENPs exhibited blocking effects (decreasing deposition rate over time) and were well-described using an unfavorable and favorable, two-site kinetic attachment model accounting for random sequential adsorption on the favorable site. Modeled maximum retention capacity and first-order attachment rate coefficient on the favorable site both increased linearly with increasing lambda, suggesting that transport parameters of ENPs in natural soils may be accurately extrapolated from transport parameters in the sand/soil mixtures. In addition, the mobility of three negatively charged ENPs (C-60, SWNT, and Ag-0 NPs) was reversely correlated with their average hydrodynamic diameters, highlighting that the average hydrodynamic diameter of negatively charged ENPs is the dominant physicochemical characteristics controlling their mobility in the Ultisol. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Wang, Dengjun; Hao, Xiuzhen; Cang, Long; Wang, Yujun; Zhou, Dongmei] Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Peoples R China.
[Su, Chunming] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Off Res & Dev, Ada, OK 74820 USA.
[Zhang, Wei] Michigan State Univ, Dept Plant Soil & Microbial Sci, Environm Sci & Policy Program, E Lansing, MI 48824 USA.
[Wang, Dengjun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
RP Zhou, DM (reprint author), Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Peoples R China.
EM dmzhou@issas.ac.cn
RI Wang, Yujun/C-6962-2013; Cang, Long/D-1155-2015;
OI Wang, Yujun/0000-0002-0921-0122; Zhang, Wei/0000-0002-2937-1732
FU National Basic Research and Development Program of China [2013CB934303];
National Natural Science Foundation of China [41125007]; USDA National
Institute of Food and Agriculture Hatch Program [MICL02248]
FX This research was supported by National Basic Research and Development
Program of China (2013CB934303), National Natural Science Foundation of
China (41125007), and USDA National Institute of Food and Agriculture
Hatch Program (MICL02248). This paper does not necessarily reflect the
views of USEPA, USDA and other funding agencies, and no official
endorsement should be inferred. The authors thank Dr. Xinhua Peng at our
Institute for assistance with measurements of the BET specific surface
area and pore size of the red soil. Comments and suggestions from two
anonymous reviewers and Editors (Dr. Laurent Charlet and Dr. Eddy
Yongping Zeng) helped us improve an earlier version of this paper.
NR 78
TC 9
Z9 10
U1 9
U2 106
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 1677
EP 1687
DI 10.1016/j.jhydrol.2014.09.053
PN B
PG 11
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AX6FH
UT WOS:000347018100036
ER
PT J
AU Ziegler, AD
Benner, SG
Tantasirin, C
Wood, SH
Sutherland, RA
Sidle, RC
Jachowski, N
Nullet, MA
Xi, LX
Snidvongs, A
Giambelluca, TW
Fox, JM
AF Ziegler, Alan D.
Benner, Shawn G.
Tantasirin, Chatchai
Wood, Spencer H.
Sutherland, Ross A.
Sidle, Roy C.
Jachowski, Nicholas
Nullet, Mike A.
Xi, Lu Xi
Snidvongs, Anond
Giambelluca, Thomas W.
Fox, Jefferson M.
TI Turbidity-based sediment monitoring in northern Thailand: Hysteresis,
variability, and uncertainty
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Soil erosion in the tropics; Stream sediment dynamics; Catchment
management; Southeast Asia; Landslides
ID MAINLAND SOUTHEAST-ASIA; TOTAL SUSPENDED-SOLIDS; HORTON OVERLAND-FLOW;
RIVER-BASIN; LAND-USE; UPLAND CATCHMENTS; WATER MANAGEMENT; MOUNTAIN
ROADS; RATING CURVES; SOURCE AREAS
AB Annual total suspended solid (TSS) loads in the Mae Sa Catchment in northern Thailand, determined with an automated, turbidity-based monitoring approach, were approximately 62,000, 33,000, and 14,000 Mg during the three years of observation. These loads were equivalent to basin yields of 839 (603-1170), 445 (217-462), and 192 (108-222) Mg km(-2) for the 74.16-km(2) catchment during 2006, 2007, and 2008, respectively. The yearly uncertainty ranges indicate our loads may be underestimated by 38-43% or overestimated by 28-33%. In determining the annual loads, discharge (Q) and turbidity (T) values were compared against 333 hand-sampled total suspended solid concentrations (TSS) measured during 18 runoff events and other flow conditions across the three-year period. Annual rainfall varied from 1632 to 1934 mm; and catchment runoff coefficients (annual runoff/annual rainfall) ranged from 0.25 to 0.41. Measured TSS ranged from 8 to 15,900 mg l(-1); the low value was associated with dry-season base flow; the latter, a wet-season storm. Storm size and location played an important role in producing clockwise, anticlockwise, and complex hysteresis in the Q-TSS relationship. Turbidity alone was a good estimator for turbidity ranges of roughly 10-2800 NTU (or concentrations approximately 25-4000 mg l(-1)). However, owing to hysteresis and high sediment concentrations that surpass the detection limits of the turbidity sensor during many annual storms, TSS was estimated best using a complex multiple regression equation based on high/low ranges of turbidity and Q as independent variables. Turbidity was not a good predictor of TSS fractions >2000 mu m. Hysteresis in the monthly Q-TSS relationship was generally clockwise over the course of the monsoon season, but infrequent large dry-season storms disrupted the pattern in some years. The large decrease in annual loads during the study was believed to be related to depletion of fine sediment delivered to the stream by several landslides occurring the year prior to the study. The study indicated the importance of monitoring Q and turbidity at fine resolutions (e.g., sub-hourly) to capture the TSS dynamics and to make accurate load estimations in this flashy headwater stream where hysteresis in the Q-TSS signature varied at several time scales. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ziegler, Alan D.; Jachowski, Nicholas; Xi, Lu Xi] Natl Univ Singapore, Dept Geog, Singapore 117568, Singapore.
[Benner, Shawn G.; Wood, Spencer H.] Boise State Univ, Dept Geosci, Boise, ID 83725 USA.
[Tantasirin, Chatchai] Kasetsart Univ, Dept Conservat, Bangkok, Thailand.
[Sutherland, Ross A.; Nullet, Mike A.; Giambelluca, Thomas W.] Univ Hawaii Manoa, Dept Geog, Honolulu, HI 96822 USA.
[Sidle, Roy C.] US EPA, Athens, GA USA.
[Snidvongs, Anond] START Thailand, Bangkok, Thailand.
[Snidvongs, Anond] Chulalongkorn Univ, Bangkok, Thailand.
[Giambelluca, Thomas W.] Nagoya Univ, Hydrospher Atmospher Res Ctr, Nagoya, Aichi 4648601, Japan.
[Fox, Jefferson M.] East West Ctr, Honolulu, HI USA.
RP Ziegler, AD (reprint author), Natl Univ Singapore, Dept Geog, 1 Arts Link Kent Ridge,AS02-04021, Singapore 117568, Singapore.
EM geoadz@nus.edu.sg
RI Benner, Shawn/A-2557-2012;
OI Benner, Shawn/0000-0003-4024-5777; Giambelluca,
Thomas/0000-0002-6798-3780
FU SARCS [95/01/CW-005]; APN [ARCP2006-06NMY, ARCP2007-01CMY]; NASA
[NNG04GH59G]; NUS [R-109-000-092-133, R-109-000-134-112]
FX This project was supported by SARCS grant 95/01/CW-005; APN grants
ARCP2006-06NMY, ARCP2007-01CMY & ARCP2007-01CMY; NASA grant NNG04GH59G,
and NUS grants R-109-000-092-133 and R-109-000-134-112. A special thanks
is given to Ms. Wimonmat Nuipakdee (Department of National Park,
Wildlife and Plants Conservation, Thailand) for providing access to the
research site. This document has been reviewed in accordance with U.S.
Environmental Protection Agency policy and approved for publication.
Mention of trade names or commercial products does not constitute an
endorsement or recommendation for use.
NR 106
TC 8
Z9 8
U1 5
U2 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD NOV 27
PY 2014
VL 519
BP 2020
EP 2039
DI 10.1016/j.jhydrol.2014.09.010
PN B
PG 20
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AX6FH
UT WOS:000347018100065
ER
PT J
AU Hand, JL
Schichtel, BA
Malm, WC
Pitchford, M
Frank, NH
AF Hand, J. L.
Schichtel, B. A.
Malm, W. C.
Pitchford, M.
Frank, N. H.
TI Spatial and seasonal patterns in urban influence on regional
concentrations of speciated aerosols across the United States
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID FINE PARTICULATE MATTER; LONG-TERM NETWORKS; NEW-YORK-CITY;
ORGANIC-CARBON; CHEMICAL-COMPOSITION; AIR-QUALITY; SAMPLING ARTIFACTS;
TRENDS NETWORK; PM2.5 EPISODES; PART 1
AB Monthly, seasonal, and annual mean estimates of urban influence on regional concentrations of major aerosol species were computed using speciated aerosol data from the rural IMPROVE network (Interagency Monitoring of Protected Visual Environments) and the United States Environmental Protection Agency's urban Chemical Speciation Network for the 2008 through 2011 period. Aggregated for sites across the continental United States, the annual mean and one standard error in urban excess (defined as the ratio of urban to nearby rural concentrations) was highest for elemental carbon (3.3 +/- 0.2), followed by ammonium nitrate (2.5 +/- 0.2), particulate organic matter (1.78 +/- 0.08), and ammonium sulfate (1.23 +/- 0.03). The seasonal variability in urban excess was significant for carbonaceous aerosols and ammonium nitrate in the West, in contrast to the low seasonal variability in the urban influence of ammonium sulfate. Generally for all species, higher excess values in the West were associated with localized urban sources while in the East excess was more regional in extent. In addition, higher excess values in the western United States in winter were likely influenced not only by differences in sources but also by combined meteorological and topographic effects. This work has implications for understanding the spatial heterogeneity of major aerosol species near the interface of urban and rural regions and therefore for designing appropriate air quality management strategies. In addition, the spatial patterns in speciated mass concentrations provide constraints for regional and global models.
C1 [Hand, J. L.; Malm, W. C.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
[Schichtel, B. A.] Natl Pk Serv, Air Resources Div, Lakewood, CO USA.
[Pitchford, M.] Univ Nevada, Desert Res Inst, Div Atmospher Sci, Reno, NV 89506 USA.
[Frank, N. H.] US EPA, Air Qual Assessment Div, Res Triangle Pk, NC 27711 USA.
RP Hand, JL (reprint author), Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
EM jlhand@colostate.edu
FU U.S. Environmental Protection Agency; National Park Service
[H2370094000]
FX IMPROVE and CSN data are available for download
(http://vista.cira.colostate.edu/improve and
http://views.cira.colostate.edu/fed, respectively). Derived results are
available from the authors. IMPROVE is a collaborative association of
state, tribal, and federal agencies, and international partners. The
U.S. Environmental Protection Agency is the primary funding source, with
contracting and research support from the National Park Service. The Air
Quality Group at the University of California, Davis, is the central
analytical laboratory, with ion analysis provided by Research Triangle
Institute and carbon analysis provided by Desert Research Institute.
This work was funded by the National Park Service under contract
H2370094000. The assumptions, findings, conclusions, judgments, and
views presented herein are those of the authors and should not be
interpreted as necessarily representing the National Park Service
policies.
NR 67
TC 4
Z9 4
U1 5
U2 26
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD NOV 27
PY 2014
VL 119
IS 22
BP 12832
EP 12849
DI 10.1002/2014JD022328
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AW5YA
UT WOS:000346345600024
ER
PT J
AU Kim, YH
Boykin, E
Stevens, T
Lavrich, K
Gilmour, MI
AF Kim, Yong Ho
Boykin, Elizabeth
Stevens, Tina
Lavrich, Katelyn
Gilmour, M. Ian
TI Comparative lung toxicity of engineered nanomaterials utilizing in
vitro, ex vivo and in vivo approaches
SO JOURNAL OF NANOBIOTECHNOLOGY
LA English
DT Article
DE Engineered nanomaterials; Lung toxicity; Alternative toxicity testing
ID CERIUM OXIDE NANOPARTICLES; TITANIUM-DIOXIDE; INTRATRACHEAL
INSTILLATION; PULMONARY INFLAMMATION; HAZARD IDENTIFICATION; PARTICULATE
MATTER; OXIDATIVE STRESS; ZINC-OXIDE; DOSIMETRY; EXPOSURE
AB Background: Although engineered nanomaterials (ENM) are currently regulated either in the context of a new chemical, or as a new use of an existing chemical, hazard assessment is still to a large extent reliant on information from historical toxicity studies of the parent compound, and may not take into account special properties related to the small size and high surface area of ENM. While it is important to properly screen and predict the potential toxicity of ENM, there is also concern that current toxicity tests will require even heavier use of experimental animals, and reliable alternatives should be developed and validated. Here we assessed the comparative respiratory toxicity of ENM in three different methods which employed in vivo, in vitro and ex vivo toxicity testing approaches.
Methods: Toxicity of five ENM (SiO2 (10), CeO2 (23), CeO2 (88), TiO2 (10), and TiO2 (200); parentheses indicate average ENM diameter in nm) were tested in this study. CD-1 mice were exposed to the ENM by oropharyngeal aspiration at a dose of 100 mu g. Mouse lung tissue slices and alveolar macrophages were also exposed to the ENM at concentrations of 22-132 and 3.1-100 mu g/mL, respectively. Biomarkers of lung injury and inflammation were assessed at 4 and/or 24 hr post-exposure.
Results: Small-sized ENM (SiO2 (10), CeO2 (23), but not TiO2 (10)) significantly elicited pro-inflammatory responses in mice (in vivo), suggesting that the observed toxicity in the lungs was dependent on size and chemical composition. Similarly, SiO2 (10) and/or CeO2 (23) were also more toxic in the lung tissue slices (ex vivo) and alveolar macrophages (in vitro) compared to other ENM. A similar pattern of inflammatory response (e. g., interleukin-6) was observed in both ex vivo and in vitro when a dose metric based on cell surface area (mu g/cm(2)), but not culture medium volume (mu g/mL) was employed.
Conclusion: Exposure to ENM induced acute lung inflammatory effects in a size- and chemical composition-dependent manner. The cell culture and lung slice techniques provided similar profiles of effect and help bridge the gap in our understanding of in vivo, ex vivo, and in vitro toxicity outcomes.
C1 [Kim, Yong Ho; Lavrich, Katelyn] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Boykin, Elizabeth; Gilmour, M. Ian] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Stevens, Tina] US EPA, Res Triangle Pk Div, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Gilmour, MI (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM gilmour.ian@epa.gov
FU EPA-UNC Toxicology Training Agreement [CR-83515201-0]; Curriculum in
Toxicology, University of North Carolina at Chapel Hill
FX We thank Debora Andrews, Judy Richards, and Richard Jaskot for technical
assistance in toxicologic analyses and Drs. Kevin Dreher and James Samet
for their review of this manuscript. The project was supported by grant
from the EPA-UNC Toxicology Training Agreement (CR-83515201-0), with the
Curriculum in Toxicology, University of North Carolina at Chapel Hill.
This paper has been reviewed by the National Health and Environmental
Effects Research Laboratory, U.S. Environmental Protection Agency, and
approved for publication. Approval does not signify that contents
necessarily reflect the views and polices of Agency, nor does the
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 48
TC 5
Z9 5
U1 1
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1477-3155
J9 J NANOBIOTECHNOL
JI J. Nanobiotechnol.
PD NOV 26
PY 2014
VL 12
AR 47
DI 10.1186/s12951-014-0047-3
PG 12
WC Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology
SC Biotechnology & Applied Microbiology; Science & Technology - Other
Topics
GA AW7HK
UT WOS:000346435100001
PM 25424549
ER
PT J
AU Arnold, KE
Brown, AR
Ankley, GT
Sumpter, JP
AF Arnold, Kathryn E.
Brown, A. Ross
Ankley, Gerald T.
Sumpter, John P.
TI Medicating the environment: assessing risks of pharmaceuticals to
wildlife and ecosystems
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Editorial Material
DE pharmaceuticals; ecotoxicology; sewage; population ecology;
contaminants; environmental risk assessment
ID PERSONAL CARE PRODUCTS; RELEVANT CONCENTRATIONS; PIMEPHALES-PROMELAS;
FATHEAD MINNOWS; GYPS VULTURES; FISH; EXPOSURE; ANTIDEPRESSANTS;
DICLOFENAC; FLUOXETINE
AB Global pharmaceutical consumption is rising with the growing and ageing human population and more intensive food production. Recent studies have revealed pharmaceutical residues in a wide range of ecosystems and organisms. Environmental concentrations are often low, but pharmaceuticals typically are designed to have biological effects at low doses, acting on physiological systems that can be evolutionarily conserved across taxa. This Theme Issue introduces the latest research investigating the risks of environmentally relevant concentrations of pharmaceuticals to vertebrate wildlife. We take a holistic, global view of environmental exposure to pharmaceuticals encompassing terrestrial, freshwater and marine ecosystems in high- and low-income countries. Based on both field and laboratory data, the evidence for and relevance of changes to physiology and behaviour, in addition to mortality and reproductive effects, are examined in terms of the population- and community-level consequences of pharmaceutical exposure on wildlife. Studies on uptake, trophic transfer and indirect effects of pharmaceuticals acting via food webs are presented. Given the logistical and ethical complexities of research in this area, several papers focus on techniques for prioritizing which compounds are most likely to harm wildlife and how modelling approaches can make predictions about the bioavailability, metabolism and toxicity of pharmaceuticals in non-target species. This Theme Issue aims to help clarify the uncertainties, highlight opportunities and inform ongoing scientific and policy debates on the impacts of pharmaceuticals in the environment.
C1 [Arnold, Kathryn E.] Univ York, Dept Environm, York YO10 5DD, N Yorkshire, England.
[Brown, A. Ross] AstraZeneca Safety, Hlth & Environm, Brixham Environm Lab, Brixham, Devon, England.
[Brown, A. Ross] Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England.
[Ankley, Gerald T.] US EPA, Duluth, MN 55804 USA.
[Sumpter, John P.] Brunel Univ, Inst Environm, Uxbridge UB8 3PH, Middx, England.
RP Arnold, KE (reprint author), Univ York, Dept Environm, York YO10 5DD, N Yorkshire, England.
EM kathryn.arnold@york.ac.uk
RI PRAZERES, KELLY/O-7715-2015; Arnold, Kathryn/F-8683-2016
OI Arnold, Kathryn/0000-0002-6485-6065
NR 92
TC 32
Z9 32
U1 23
U2 182
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD NOV 19
PY 2014
VL 369
IS 1656
AR 20130569
DI 10.1098/rstb.2013.0569
PG 11
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AQ8VK
UT WOS:000343114500001
ER
PT J
AU LaLone, CA
Berninger, JP
Villeneuve, DL
Ankley, GT
AF LaLone, Carlie A.
Berninger, Jason P.
Villeneuve, Daniel L.
Ankley, Gerald T.
TI Leveraging existing data for prioritization of the ecological risks of
human and veterinary pharmaceuticals to aquatic organisms
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Review
DE pharmacokinetics; SeqAPASS; adverse outcome pathway; read-across;
molecular target conservation
ID MINNOW PIMEPHALES-PROMELAS; MEDAKA ORYZIAS-LATIPES; DOPAMINE-RECEPTOR
ANTAGONIST; TERM REPRODUCTION ASSAY; MALE FATHEAD MINNOWS; EARLY-LIFE
STAGES; JAPANESE MEDAKA; OREOCHROMIS-NILOTICUS; CURRENT PERSPECTIVES;
GENE-EXPRESSION
AB Medicinal innovation has led to the discovery and use of thousands of human and veterinary drugs. With this comes the potential for unintended effects on non-target organisms exposed to pharmaceuticals inevitably entering the environment. The impracticality of generating whole-organism chronic toxicity data representative of all species in the environment has necessitated prioritization of drugs for focused empirical testing as well as field monitoring. Current prioritization strategies typically emphasize likelihood for exposure (i.e. predicted/measured environmental concentrations), while incorporating only rather limited consideration of potential effects of the drug to non-target organisms. However, substantial mammalian pharmacokinetic and mechanism/mode of action (MOA) data are produced during drug development to understand drug target specificity and efficacy for intended consumers. An integrated prioritization strategy for assessing risks of human and veterinary drugs would leverage available pharmacokinetic and toxicokinetic data for evaluation of the potential for adverse effects to non-target organisms. In this reiview, we demonstrate the utility of read-across approaches to leverage mammalian absorption, distribution, metabolism and elimination data; analyse cross-species molecular target conservation and translate therapeutic MOA to an adverse outcome pathway(s) relevant to aquatic organisms as a means to inform prioritization of drugs for focused toxicity testing and environmental monitoring.
C1 [LaLone, Carlie A.] Univ Minnesota, Coll Food Agr & Nat Resource Sci, Water Resources Ctr, St Paul, MN 55108 USA.
[LaLone, Carlie A.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Berninger, Jason P.] CNR, Duluth, MN 55804 USA.
RP LaLone, CA (reprint author), Univ Minnesota, Coll Food Agr & Nat Resource Sci, Water Resources Ctr, 1985 Buford Ave, St Paul, MN 55108 USA.
EM lalone.carlie@epa.gov
RI Berninger, Jason/O-2401-2016
OI Berninger, Jason/0000-0003-3045-7899
NR 92
TC 11
Z9 11
U1 4
U2 38
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD NOV 19
PY 2014
VL 369
IS 1656
AR 20140022
DI 10.1098/rstb.2014.0022
PG 10
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA AQ8VK
UT WOS:000343114500017
ER
PT J
AU Phillips, MB
Yoon, MY
Young, B
Tan, YM
AF Phillips, Martin B.
Yoon, Miyoung
Young, Bruce
Tan, Yu-Mei
TI Analysis of biomarker utility using a PBPK/PD model for carbaryl
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE carbaryl; PBPK; biomarkers; biomarkers of exposure; biomarkers of
effect; computational toxicology
ID EXPOSURE ASSESSMENT; BIOMONITORING DATA; SUPPORT EXPOSURE; SENSITIVITY;
PESTICIDES; HUMANS
AB There are many types of biomarkers; the two common ones are biomarkers of exposure and biomarkers of effect. The utility of a biomarker for estimating exposures or predicting risks depends on the strength of the correlation between biomarker concentrations and exposure/effects. In the current study, a combined exposure and physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model of carbaryl was used to demonstrate the use of computational modeling for providing insight into the selection of biomarkers for different purposes. The Cumulative and Aggregate Risk Evaluation System (CARES) was used to generate exposure profiles, including magnitude and timing, for use as inputs to the PBPK/PD model. The PBPK/PD model was then used to predict blood concentrations of carbaryl and urine concentrations of its principal metabolite, 1-naphthol (1-N), as biomarkers of exposure. The PBPK/PD model also predicted acetylcholinesterase (AChE) inhibition in red blood cells (RBC) as a biomarker of effect. The correlations of these simulated biomarker concentrations with intake doses or brain AChE inhibition (as a surrogate of effects) were analyzed using a linear regression model. Results showed that 1-N in urine is a better biomarker of exposure than carbaryl in blood, and that 1-N in urine is correlated with the dose averaged over the last 2 days of the simulation. They also showed that RBC AChE inhibition is an appropriate biomarker of effect. This computational approach can be applied to a wide variety of chemicals to facilitate quantitative analysis of biomarker utility.
C1 [Phillips, Martin B.] US EPA, Natl Exposure Res Lab, Duluth, MN USA.
[Yoon, Miyoung] Hamner Inst Hlth Sci, Inst Chem Safety Sci, Res Triangle Pk, NC USA.
[Young, Bruce] Bayer CropSci, Res Triangle Pk, NC USA.
[Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Tan, YM (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr,Mail Code E205-01, Res Triangle Pk, NC 27711 USA.
EM tan.cecilia@epa.gov
OI Phillips, Martin/0000-0002-6282-529X; Yoon, Miyoung/0000-0002-3653-3488
FU Oak Ridge Institute for Science and Education (ORISE)
FX Dr. Martin Phillips was funded by a post-doctoral fellowship through the
Oak Ridge Institute for Science and Education (ORISE).
NR 28
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Z9 2
U1 1
U2 7
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 18
PY 2014
VL 5
AR 246
DI 10.3389/fphar.2014.00246
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AX8IJ
UT WOS:000347153000001
PM 25477820
ER
PT J
AU Landis, MS
Ryan, JV
ter Schure, AFH
Laudal, D
AF Landis, Matthew S.
Ryan, Jeffrey V.
ter Schure, Arnout F. H.
Laudal, Dennis
TI Behavior of Mercury Emissions from a Commercial Coal-Fired Power Plant:
The Relationship between Stack Speciation and Near-Field Plume
Measurements
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID REACTIVE GASEOUS MERCURY; PHOTOLYTIC REDUCTION; ATMOSPHERIC MERCURY; WET
DEPOSITION; EASTERN OHIO; AMBIENT AIR; HG(II); OXIDATION; AEROSOLS
AB The reduction of divalent gaseous mercury (Hg-II) to elemental gaseous mercury (Hg-0) in a commercial coal-fired power plant (CFPP) exhaust plume was investigated by simultaneous measurement in-stack and in-plume as part of a collaborative study among the U.S. EPA, EPRI, EERC, and Southern Company. In-stack continuous emission monitoring data were used to establish the CFPP's real-time mercury speciation and plume dilution tracer species (SO2, NOX) emission rates, and an airship was utilized as an airborne sampling platform to maintain static position with respect to the exhaust plume centerline for semicontinuous measurement of target species. Varying levels of Hg-II concentration (2.39-3.90 mu g m(-3)) and percent abundance (similar to 87-99%) in flue gas and in-plume reduction were observed. The existence and magnitude of Hg-II reduction to Hg-0 (0-55%) observed varied with respect to the types and relative amounts of coals combusted, suggesting that exhaust plume reduction occurring downwind of the CFPP is influenced by coal chemical composition and characteristics.
C1 [Landis, Matthew S.; Ryan, Jeffrey V.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[ter Schure, Arnout F. H.] Elect Power Res Inst, Palo Alto, CA 94304 USA.
[Laudal, Dennis] Univ N Dakota, Energy & Environm Res Ctr, Grand Forks, ND 58202 USA.
RP Landis, MS (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
EM landis.matthew@epa.gov
RI Landis, Matthew/P-5149-2014
OI Landis, Matthew/0000-0002-8742-496X
FU United States Environmental Protection Agency through Office of Research
and Development through Advanced Monitoring Initiative
FX The United States Environmental Protection Agency through its Office of
Research and Development funded this research partially through an
Advanced Monitoring Initiative Grant. It has been subjected to Agency
review and approved for publication. Mention of trade names or
commercial products do not constitute an endorsement or recommendation
for use. We thank John Jansen and Justin Walters (Southern Company), and
Dwain Waters (Gulf Power) in particular for access to the Crist Plant
and collaboration with the project; Airship Management Services (AMS)
and Integrated Systems Solutions Incorporated (ISSI) for airship
operations and logistical support; Ed Brown (EPA) for Hg measurement
support; Mike Wheeler (Alion) and Chris Winterrowd (ARCADIS) for
instrument calibration support; and Jane Caffery (University of West
Florida) for providing laboratory space and hosting our Sodar system. We
also thank Eric Edgerton from Atmospheric Research and Analysis, and
Leonard Levin from EPRI for their contributions to this project.
NR 32
TC 12
Z9 13
U1 6
U2 48
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 18
PY 2014
VL 48
IS 22
BP 13540
EP 13548
DI 10.1021/es500783t
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AT9RC
UT WOS:000345262900062
PM 25325168
ER
PT J
AU Cui, YX
Palii, SS
Innes, CL
Paules, RS
AF Cui, Yuxia
Palii, Stela S.
Innes, Cynthia L.
Paules, Richard S.
TI Depletion of ATR selectively sensitizes ATM-deficient human mammary
epithelial cells to ionizing radiation and DNA-damaging agents
SO CELL CYCLE
LA English
DT Article
DE ATM and Rad3-related (ATR); DNA damage response; G(2); M checkpoint;
ionizing radiation; synthetic lethality
ID EARLY EMBRYONIC LETHALITY; CANCER-CELLS; TARGETING ATR;
ATAXIA-TELANGIECTASIA; INDUCED AUTOPHAGY; G(2) CHECKPOINT; TUMOR-CELLS;
INHIBITION; APOPTOSIS; RESISTANCE
AB DNA damage response (DDR) to double strand breaks is coordinated by 3 phosphatidylinositol 3-kinase-related kinase (PIKK) family members: the ataxia-telangiectasia mutated kinase (ATM), the ATM and Rad3-related (ATR) kinase and the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). ATM and ATR are central players in activating cell cycle checkpoints and function as an active barrier against genome instability and tumorigenesis in replicating cells. Loss of ATM function is frequently reported in various types of tumors, thus placing more reliance on ATR for checkpoint arrest and cell survival following DNA damage. To investigate the role of ATR in the G(2)/M checkpoint regulation in response to ionizing radiation (IR), particularly when ATM is deficient, cell lines deficient of ATM, ATR, or both were generated using a doxycycline-inducible lentiviral system. Our data suggests that while depletion of ATR or ATM alone in wild-type human mammary epithelial cell cultures (HME-CCs) has little effect on radiosensitivity or IR-induced G2/M checkpoint arrest, depletion of ATR in ATM-deficient cells causes synthetic lethality following IR, which correlates with severe G(2)/M checkpoint attenuation. ATR depletion also inhibits IR-induced autophagy, regardless of the ATM status, and enhances IR-induced apoptosis particularly when ATM is deficient. Collectively, our results clearly demonstrate that ATR function is required for the IR-induced G(2)/M checkpoint activation and subsequent survival of cells with ATM deficiency. The synthetic lethal interaction between ATM and ATR in response to IR supports ATR as a therapeutic target for improved anti-cancer regimens, especially in tumors with a dysfunctional ATM pathway.
C1 [Cui, Yuxia; Palii, Stela S.; Innes, Cynthia L.; Paules, Richard S.] Natl Inst Hlth Res, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Paules, RS (reprint author), Natl Inst Hlth Res, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
EM paules@niehs.nih.gov
FU NIH, National Institute of Environmental Health Sciences [Z01ES021157]
FX This research was supported by the Intramural Research Program of the
NIH, National Institute of Environmental Health Sciences (Z01ES021157).
NR 43
TC 2
Z9 2
U1 0
U2 3
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1538-4101
EI 1551-4005
J9 CELL CYCLE
JI Cell Cycle
PD NOV 15
PY 2014
VL 13
IS 22
BP 3541
EP 3550
DI 10.4161/15384101.2014.960729
PG 10
WC Cell Biology
SC Cell Biology
GA AZ6KM
UT WOS:000348328800013
PM 25483091
ER
PT J
AU Cantrell, SA
Molina, M
Lodge, DJ
Rivera-Figueroa, FJ
Ortiz-Hernandez, ML
Marchetti, AA
Cyterski, MJ
Perez-Jimenez, JR
AF Cantrell, Sharon A.
Molina, Marirosa
Lodge, D. Jean
Rivera-Figueroa, Francisco J.
Ortiz-Hernandez, Maria L.
Marchetti, Albany A.
Cyterski, Mike J.
Perez-Jimenez, Jose R.
TI Effects of a simulated hurricane disturbance on forest floor microbial
communities
SO FOREST ECOLOGY AND MANAGEMENT
LA English
DT Article
DE Soil and leaf litter microbial communities; Canopy opening; Debris
addition; Green leaves; Senesced leaves; Spatiotemporal variations
ID PUERTO-RICO; TROPICAL FORESTS; CLIMATE-CHANGE; WET FOREST; SOIL;
DIVERSITY; BIOMASS; DECOMPOSITION; STABILITY; RESPONSES
AB Forest floor microbial communities play a critical role in the processes of decomposition and nutrient cycling. The impact of cultivation, contamination, fire, and land management on soil microbial communities have been studied but there are few studies of microbial responses to the effects of tropical storms. The Canopy Trimming Experiment was executed in the Luquillo Experimental Forest of Puerto Rico to decouple two prominent effects of a hurricane-canopy opening and debris deposition on the forest floor-on forest biota and processes. We studied the independent and interactive hurricane effects of canopy openness and debris deposition on the relative abundance and diversity of microorganisms in soil and leaf litter using ester link fatty acids methyl esters (EL-FAME) analysis, and terminal restriction fragment length polymorphism (TRFLP) profile. Non-metric multi-dimensional scaling analysis of soil FAME showed soil microbial community composition was significantly different between pre- and post-hurricane periods including in the unmanipulated plots and among blocks, but there was no significant separation among treatments. This shows that there are strong spatiotemporal dynamics in the structure of soil microbial communities which masked hurricane effects (canopy opening and deposition of green debris). The degree of difference among treatments decreased with time in soil which suggests that our study may have started too late after the manipulations and therefore missed the effects of canopy opening and debris addition. This reflects the resilience of the soil microbial communities. The richness of soil bacterial TRF's however, showed a significant positive response to added debris. Neither fungal nor bacterial NMDS clusters for leaf microbial communities showed significant grouping by treatment, time or litter cohorts. Significant differences were observed through time for fungal diversity in green leaves and for both bacterial and fungal diversity in senesced leaves. Senesced leaves microbial succession apparently stopped when both the canopy and debris were removed, and there was a suggestive trimming by time interaction which reflects the susceptibility of the leaf litter microbial community. Our findings contribute to the understanding of how microbial community structures can be affected by hurricane disturbances and forestry management practices that remove canopy and debris from the forest floor, and shows the need to analyze the microbial community immediately after the disturbance. Short-term changes in microbial communities due to forest disturbances can have significant implications for litter decomposition, soil organic matter accumulation, nutrient cycling, and food web dynamics in tropical forests. All of these factors should be taken into consideration when selecting the appropriate forest management practice. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Cantrell, Sharon A.; Rivera-Figueroa, Francisco J.; Ortiz-Hernandez, Maria L.; Perez-Jimenez, Jose R.] Univ Turabo, Dept Biol, Gurabo, PR 00778 USA.
[Molina, Marirosa; Cyterski, Mike J.] US EPA, ORD, Athens, GA 30605 USA.
[Lodge, D. Jean] USDA, Ctr Forest Mycol Res, Forest Serv, No Res Stn, Luquillo, PR 00773 USA.
[Marchetti, Albany A.] Univ Estadual Norte Fluminense, Campos Dos Goytacazes, Brazil.
RP Cantrell, SA (reprint author), Univ Turabo, Sch Sci & Technol, Dept Biol, POB 3030, Gurabo, PR 00778 USA.
EM scantrel@suagm.edu; molina.marirosa@epa.gov; djlodge@caribe.net;
frivera@suagm.edu; albanymarchetti@yahoo.com.br; ut_jperezjm@suagm.edu
FU U.S. National Science Foundation [DEB-0218039, DEB-0620910]; University
of Puerto Rico; International Institute of Tropical Forestry, USDA
Forest Service
FX This research was funded by grants DEB-0218039 and DEB-0620910 from the
U.S. National Science Foundation to the Institute for Tropical Ecosystem
Studies, University of Puerto Rico, and the International Institute of
Tropical Forestry, USDA Forest Service, as part of the Luquillo
Long-Term Ecological Research Program. We also thank A. Shiels and
anonymous reviewers for the pre-review and suggestions. Our sincere
gratitude goes to Dr. Michael Willig and Dr. Steve Presely for the help
with the statistical analysis using the program R. This paper has been
reviewed in accordance with the USEPA and USDA-Forest Service's peer and
administrative review policies and approved for publication. Mention of
trade-names or commercial products does not constitute endorsement or
recommendation for use by USEPA or USDA. This paper was prepared by US
Government employees and is thus in the public domain and not subject to
copyright.
NR 53
TC 6
Z9 6
U1 3
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1127
EI 1872-7042
J9 FOREST ECOL MANAG
JI For. Ecol. Manage.
PD NOV 15
PY 2014
VL 332
BP 22
EP 31
DI 10.1016/j.foreco.2014.07.010
PG 10
WC Forestry
SC Forestry
GA AY5EK
UT WOS:000347595700003
ER
PT J
AU Stahl, LL
Snyder, BD
Olsen, AR
Kincaid, TM
Wathen, JB
McCarty, HB
AF Stahl, Leanne L.
Snyder, Blame D.
Olsen, Anthony R.
Kincaid, Thomas M.
Wathen, John B.
McCarty, Harry B.
TI Perfluorinated compounds in fish from US urban rivers and the Great
Lakes
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Fish tissue; Perfluorinated compounds; Urban rivers; Great Lakes;
Probabilistic survey
ID PERFLUOROALKYL CONTAMINANTS; POLYFLUOROALKYL SUBSTANCES; PERFLUOROOCTANE
SULFONATE; ORGANIC-COMPOUNDS; HUMAN BLOOD; SERUM; ACIDS; TROUT; CHAIN;
PFOA
AB Perfluorinated compounds (PFCs) have recently received scientific and regulatory attention due to their broad environmental distribution, persistence, bioaccumulative potential, and toxicity. Studies suggest that fish consumption may be a source of human exposure to perfluorooctane sulfonate (PFOS) or long-chain perfluorocarboxylic acids. Most PFC fish tissue literature focuses on marine fish and waters outside of the United States (U.S.). To broaden assessments in U.S. fish, a characterization of PFCs in freshwater fish was initiated on a national scale using an unequal probability design during the U.S. Environmental Protection Agency's (EPA's) 2008-2009 National Rivers and Streams Assessment (NRSA) and the Great Lakes Human Health Fish Tissue Study component of the 2010 EPA National Coastal Condition Assessment (NCCA/GL). Fish were collected from randomly selected locations-164 urban river sites and 157 nearshore Great Lake sites. The probability design allowed extrapolation to the sampled population of 17,059 km in urban rivers and a nearshore area of 11,091 km(2) in the Great Lakes. Fillets were analyzed for 13 PFCs using high-performance liquid chromatography tandem mass spectrometry. Results showed that PFOS dominated in frequency of occurrence, followed by three other longer-chain PFCs (perfluorodecanoic acid, perfluoroundecanoic acid, and perfluorododecanoic acid). Maximum PFOS concentrations were 127 and 80 ng/g in urban river samples and Great Lakes samples, respectively. The range of NRSA PFOS detections was similar to literature accounts from targeted riverine fish sampling. NCCA/GL PFOS levels were lower than those reported by other Great Lakes researchers, but generally higher than values in targeted inland lake studies. The probability design allowed development of cumulative distribution functions (CDFs) to quantify PFOS concentrations versus the sampled population, and the application of fish consumption advisory guidance to the CDFs resulted in an estimation of the proportion of urban rivers and the Great Lakes that exceed human health protection thresholds. (C) 2014 Published by Elsevier B.V.
C1 [Stahl, Leanne L.; Wathen, John B.] US EPA, OW Off Sci & Technol, Washington, DC 20460 USA.
[Snyder, Blame D.] Tetra Tech Inc, Ctr Ecol Sci, Owings Mills, MD 21117 USA.
[Olsen, Anthony R.; Kincaid, Thomas M.] ORD Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[McCarty, Harry B.] CSC, Alexandria, VA 22310 USA.
RP Stahl, LL (reprint author), US EPA, OW Off Sci & Technol, 1200 Penn Ave,NW MC 4305, Washington, DC 20460 USA.
EM stahl.leanne@epa.gov; blaine.snyder@tetratech.com; olsen.tony@epa.gov;
kincaid.tom@epa.gov; wathen.john@epa.gov; hmccarty@csc.com
FU U.S. Environmental Protection Agency; EPA [EP-C-04-030, EP-C-06-085,
EP-C-09-019, EP-C-10-060]
FX This study was funded by the U.S. Environmental Protection Agency, and
technical support was provided under EPA Contracts EP-C-04-030,
EP-C-06-085, EP-C-09-019, and EP-C-10-060. The manuscript has been
subjected to review and approved for publication by U.S. EPA's Office of
Research and Development and EPA's Office of Water. Approval does not
signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 65
TC 8
Z9 9
U1 8
U2 88
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 15
PY 2014
VL 499
BP 185
EP 195
DI 10.1016/j.scitotenv.2014.07.126
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5GN
UT WOS:000343613200020
PM 25190044
ER
PT J
AU Wallis, LK
Diamond, SA
Ma, HB
Hoff, DJ
Al-Abed, SR
Li, SB
AF Wallis, Lindsay K.
Diamond, Stephen A.
Ma, Hongbo
Hoff, Dale J.
Al-Abed, Souhail R.
Li, Shibin
TI Chronic TiO2 nanoparticle exposure to a benthic organism, Hyalella
azteca: impact of solar UV radiation and material surface coatings on
toxicity
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Nano-TiO2; Chronic toxicity; Phototoxicity; Hyalella azteca; Growth
ID TITANIUM-DIOXIDE NANOPARTICLES; DAPHNIA-MAGNA; PHOTOTOXICITY;
ENVIRONMENT; SUNSCREENS; NANOMATERIALS; IRRADIATION; NANO-TIO2;
AMPHIPOD; WATER
AB There is limited information on the chronic effects of nanomaterials to benthic organisms, as well as environmental mitigating factors that might influence this toxicity. The present study aimed to fill these data gaps by examining various growth endpoints (weight gain, instantaneous growth rate, and total protein content) for up to a 21 d sediment exposure of TiO2 nanoparticles (nano-TiO2) to a representative benthic species, Hyalella azteca. An uncoated standard, P25, and an Al(OH)(3) coated nano-TiO2 used in commercial products were added to sediment at 20 mg/L or 100 mg/L Under test conditions, UV exposure alone was shown to be a greater cause of toxicity than even these high levels of nano-TiO2 exposure, indicating that different hazards need to be addressed in toxicity testing scenarios. In addition, this study showed the effectiveness of a surface coating on the decreased photoactivity of the material, as the addition of an Al(OH)(3) coating showed a dramatic decrease in reactive oxygen species (ROS) production. However, this reduced photoactivity was found to be partially restored when the coating had been degraded, leading to the need for future toxicity tests which examine the implications of weathering events on particle surface coatings. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Wallis, Lindsay K.; Hoff, Dale J.; Li, Shibin] US EPA, Off Res & Dev, Mid Continent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA.
[Diamond, Stephen A.] Nanosafe Inc, Blacksburg, VA USA.
[Ma, Hongbo] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53211 USA.
[Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Li, SB (reprint author), 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM lishibinepa@gmail.com
NR 41
TC 6
Z9 6
U1 6
U2 51
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 15
PY 2014
VL 499
BP 356
EP 362
DI 10.1016/j.scitotenv.2014.08.068
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5GN
UT WOS:000343613200037
PM 25203828
ER
PT J
AU Yu, SC
Alapaty, K
Mathur, R
Pleim, J
Zhang, YH
Nolte, C
Eder, B
Foley, K
Nagashima, T
AF Yu, Shaocai
Alapaty, Kiran
Mathur, Rohit
Pleim, Jonathan
Zhang, Yuanhang
Nolte, Chris
Eder, Brian
Foley, Kristen
Nagashima, Tatsuya
TI Attribution of the United States "warming hole'': Aerosol indirect
effect and precipitable water vapor
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CLIMATE RESPONSE; ANTHROPOGENIC AEROSOLS; MODEL; 20TH-CENTURY;
TEMPERATURE; SYSTEM; CMIP5; SIMULATIONS; VARIABILITY; RADIATION
AB Aerosols can influence the climate indirectly by acting as cloud condensation nuclei and/or ice nuclei, thereby modifying cloud optical properties. In contrast to the widespread global warming, the central and south central United States display a noteworthy overall cooling trend during the 20th century, with an especially striking cooling trend in summertime daily maximum temperature (T-max) (termed the U.S. "warming hole''). Here we used observations of temperature, shortwave cloud forcing (SWCF), longwave cloud forcing (LWCF), aerosol optical depth and precipitable water vapor as well as global coupled climate models to explore the attribution of the "warming hole''. We find that the observed cooling trend in summer T-max can be attributed mainly to SWCF due to aerosols with offset from the greenhouse effect of precipitable water vapor. A global coupled climate model reveals that the observed "warming hole'' can be produced only when the aerosol fields are simulated with a reasonable degree of accuracy as this is necessary for accurate simulation of SWCF over the region. These results provide compelling evidence of the role of the aerosol indirect effect in cooling regional climate on the Earth. Our results reaffirm that LWCF can warm both winter T-max and T-min.
C1 [Yu, Shaocai] Zhejiang Univ, Coll Environm & Resource Sci, Res Ctr Air Pollut & Hlth, Hangzhou 310058, Zhejiang, Peoples R China.
[Alapaty, Kiran; Mathur, Rohit; Pleim, Jonathan; Nolte, Chris; Eder, Brian; Foley, Kristen] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Zhang, Yuanhang] Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China.
[Nagashima, Tatsuya] Natl Inst Environm Studies, Tsukuba, Ibaraki 3058506, Japan.
RP Yu, SC (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Res Ctr Air Pollut & Hlth, Hangzhou 310058, Zhejiang, Peoples R China.
EM shaocaiyu@zju.edu.cn
RI Zhang, Yuanhang/F-7038-2011; Nolte, Christopher/H-4345-2012; yu,
shaocai/G-7806-2011; yu, shaocai/F-1394-2014; Pleim, Jonathan
Pleim/C-1331-2017
OI Nolte, Christopher/0000-0001-5224-9965; Pleim, Jonathan
Pleim/0000-0001-6190-6082
FU United States Environmental Protection Agency through Office of Research
and Development; Zhejiang 1,000 Talent Plan; Research Center for Air
Pollution and Health in Zhejiang University
FX We thank Prof. Susan Solomon for insightful discussions that led to a
substantial strengthening of the manuscript, Prof. Daniel Rosenfeld and
Dr. Christian Hogrefe for helpful comments. We thank the CERES, GHCNM,
MODIS and WCRP CMIP5 groups for producing the data used in this paper.
The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here.
It has been subjected to Agency's administrative review and approved for
publication. Analyses and visualizations used in this study were
produced with the Giovanni online data system, developed and maintained
by the NASA GES DISC. We also acknowledge the MODIS mission scientists
and associated NASA personnel for the production of the data used in
this research effort. The part of this work is supported by the
"Zhejiang 1,000 Talent Plan'' and Research Center for Air Pollution and
Health in Zhejiang University.
NR 41
TC 18
Z9 18
U1 4
U2 36
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 6
PY 2014
VL 4
AR 6929
DI 10.1038/srep06929
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS5MP
UT WOS:000344315200001
PM 25373416
ER
PT J
AU Ihlaseh-Catalano, SM
Bailey, KA
Cardoso, APF
Ren, HZ
Fry, RC
de Camargo, JLV
Wolf, DC
AF Ihlaseh-Catalano, Shadia M.
Bailey, Kathryn A.
Cardoso, Ana Paula F.
Ren, Hongzu
Fry, Rebecca C.
de Camargo, Joao Lauro V.
Wolf, Douglas C.
TI Dose and temporal effects on gene expression profiles of urothelial
cells from rats exposed to diuron
SO TOXICOLOGY
LA English
DT Article
DE Diuron; Rat urinary bladder; Carcinogenesis; Gene expression profiling;
Microarray analysis; Cell adhesion
ID URINARY-BLADDER CARCINOGENESIS; MALE WISTAR RATS; MODE; RESPONSES;
TOXICITY; CANCER; BETA
AB Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a substituted urea herbicide that at high dietary levels (2500 ppm) induces rat urinary bladder hyperplasia after 20 weeks of exposure and neoplasia after 2 years. The effects on the urothelium after short-term exposure have not been described. The present 7-day study evaluated the dose-dependency of urothelial alterations in the urinary bladder using light microscopy, scanning electron microscopy, and genome-wide transcriptional profiling. Male Wistar rats were fed 0,125, 500, 2500 ppm diuron for 7 days. The urinary bladder and isolated urothelial cells of these animals were processed for microscopic examination and gene expression profiling, respectively. No significant treatment-related morphologic effects were observed. The number of differentially expressed genes (DEGs) in the exposed groups increased with diuron levels. Diuron-altered genes involved in cell-to-cell interactions and tissue organization were identified in all treatment groups. After 7 days of diuron exposure, transcriptional responses were observed in the urothelium in the absence of clear morphologic changes. These morphological findings are different from those observed in a previous study in which 20 weeks of diuron exposure was associated with simple hyperplasia secondary to the persistent cytotoxicity and necrosis associated with continuous cellular regeneration. Comparison of the gene expression profiles of rats exposed to the 2500 ppm carcinogenic diuron dose for 7 days versus 20 weeks revealed few similarities between these two time points at the gene or pathway level. Taken together, these data provide insight into the dose- and temporal-dependent morphological and transcriptional changes associated with diuron exposure that may lead to the development of tumors in the rat urinary bladder. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Ihlaseh-Catalano, Shadia M.; Cardoso, Ana Paula F.; de Camargo, Joao Lauro V.] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Ctr Evaluat Environm Impact Human Hlth TOXICAM, BR-18618000 Botucatu, SP, Brazil.
[Bailey, Kathryn A.; Fry, Rebecca C.] UNC Gillings Sch Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27559 USA.
[Ren, Hongzu; Wolf, Douglas C.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP de Camargo, JLV (reprint author), UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Ctr Evaluat Environm Impact Human Hlth TOXICAM, BR-18618000 Botucatu, SP, Brazil.
EM shadia.catalano@basf.com; katie.bailey@syngenta.com;
anaferragut@fmb.unesp.br; ren.hongzu@epa.gov; rfry@unc.edu;
decam@fmb.unesp.br; USA.Doug.Wolf@syngenta.com
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
[06/60506-1, 08/55644-1, 09/02754-7]; Center for the Evaluation of the
Environmental Impact on Human Health (TOXICAM, Botucatu Medical School,
Univ. Estadual Paulista); U.S. Environmental Protection Agency (U.S.
EPA); National Institute of Environmental Health Sciences (NIEHS) [T32
ES7018]
FX This work was supported by the Fundacao de Amparo a Pesquisa do Estado
de Sao Paulo (FAPESP Grants No. 06/60506-1, 08/55644-1 and 09/02754-7),
Center for the Evaluation of the Environmental Impact on Human Health
(TOXICAM, Botucatu Medical School, Univ. Estadual Paulista), U.S.
Environmental Protection Agency (U.S. EPA), and the National Institute
of Environmental Health Sciences (NIEHS, T32 ES7018).
NR 26
TC 1
Z9 2
U1 3
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD NOV 5
PY 2014
VL 325
BP 21
EP 30
DI 10.1016/j.tox.2014.08.005
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA AR7UO
UT WOS:000343785400003
PM 25152437
ER
PT J
AU Shalamzari, MS
Kahnt, A
Vermeylen, R
Kleindienst, TE
Lewandowski, M
Cuyckens, F
Maenhaut, W
Claeys, M
AF Shalamzari, Mohammad Safi
Kahnt, Ariane
Vermeylen, Reinhilde
Kleindienst, Tadeusz E.
Lewandowski, Michael
Cuyckens, Filip
Maenhaut, Willy
Claeys, Magda
TI Characterization of Polar Organosulfates in Secondary Organic Aerosol
from the Green Leaf Volatile 3-Z-Hexenal
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ATMOSPHERIC AEROSOLS; MASS-SPECTROMETRY; ISOPRENE; PHOTOOXIDATION;
PHOTOLYSIS; KINETICS; DEFENSE
AB Evidence is provided That the green leaf volatiles 3-Z- hexenal serves as a precursor for biogenic secondary organic aersol through the formation of polar organosulfates (Os) with molecular weight (MW) 226. The MW 226 C-6-OSs were Chemically elucidated, along with structurally similar MW 212 C-5-OSs, whose biogenic precursor is likely related to 3-Z-hexenal but still remains unknown. The MW: 226 and 212 OSs have a substantial abundance in ambient fine aerosol from K-puszta, Hungary, which is comparable to that of the isoprene-related MW 216 OSs, known to be formed: through sulfation of C-5-epoxydiols, second-generation gas-phase photooxidation products of isoprene. Using detailed interpretation of negative-ion electrospray ionization mass spectral data, the MW 226, compounds are assigned to isomeric sulfate esters of 3,4-dihydroxyhex-5-enoic acid with the sulfate group located or C-4 position. Two MW 212 compounds present in: ambient fine aerosol are attributed to isomeric sulfate :esters of 2,3-dihydroxypent-4-enoic acid, of which two are sulfated at C-3 and one is sulfated at C-2. The formation of the MW 226 :OSs is tentatively explained through photooxidation of 3-Z-hexenal in, the gas phase, resulting in alkoxy radical, followed by a rearrangement and subsequent sulfation of the epoxy group in the particle phase.
C1 [Shalamzari, Mohammad Safi; Kahnt, Ariane; Vermeylen, Reinhilde; Maenhaut, Willy; Claeys, Magda] Univ Antwerp, Dept Pharmaceut Sci, BE-2610 Antwerp, Belgium.
[Shalamzari, Mohammad Safi; Maenhaut, Willy] Univ Ghent, Dept Analyt Chem, BE-9000 Ghent, Belgium.
[Kleindienst, Tadeusz E.; Lewandowski, Michael] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Cuyckens, Filip] Janssen Res & Dev, Drug Metab & Pharmacokinet, BE-2340 Beerse, Belgium.
RP Claeys, M (reprint author), Univ Antwerp, Dept Pharmaceut Sci, BE-2610 Antwerp, Belgium.
EM magda.claeys@uantwerpen.be
RI Maenhaut, Willy/M-3091-2013;
OI Maenhaut, Willy/0000-0002-4715-4627; Cuyckens, Filip/0000-0003-4956-1418
NR 35
TC 13
Z9 13
U1 6
U2 44
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12671
EP 12678
DI 10.1021/es503226b
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100024
PM 25271849
ER
PT J
AU Isaacs, KK
Glen, WG
Egeghy, P
Goldsmith, MR
Smith, L
Vallero, D
Brooks, R
Grulke, CM
Ozkaynak, H
AF Isaacs, Kristin K.
Glen, W. Graham
Egeghy, Peter
Goldsmith, Michael-Rock
Smith, Luther
Vallero, Daniel
Brooks, Raina
Grulke, Christopher M.
Oezkaynak, Haluk
TI SHEDS-HT: An Integrated Probabilistic Exposure Model for Prioritizing
Exposures to Chemicals with Near-Field and Dietary Sources
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID CHILDRENS RESIDENTIAL EXPOSURE; SEMIVOLATILE ORGANIC-COMPOUNDS; PERSONAL
CARE PRODUCTS; COSMETIC PRODUCTS; CONSUMER PRODUCTS; RISK-ASSESSMENT;
INDOOR ENVIRONMENT; CHLORPYRIFOS; PESTICIDES; CALIFORNIA
AB United States Environmental Protection Agency (USEPA) researchers are developing a strategy for high-throughput (HT) exposure-based prioritization of chemicals under the ExpoCast program. These novel modeling approaches for evaluating chemicals based on their potential for biologically relevant human exposures will inform toxicity testing and prioritization for chemical risk assessment. Based on probabilistic methods and algorithms developed for The Stochastic Human Exposure and Dose Simulation Model for Multimedia, Multipathway Chemicals (SHEDS-MM), a new mechanistic modeling approach has been developed to accommodate high-throughput (HT) assessment of exposure potential. In this SHEDS-HT model, the residential and dietary modules of SHEDS-MM have been operationally modified to reduce the user burden, input data demands and run times of the higher-tier model, while maintaining critical features and inputs that influence exposure. The model has been implemented in R; the modeling framework links chemicals to consumer product categories or food groups (and thus exposure scenarios) to predict HT exposures and intake doess. Initially, SHEDS-HT has been applied to 2507 organic chemicals associated with consumer products and agricultural pesticides. These evaluations employ data from recent USEPA efforts to characterize usage (prevalence, frequency and magnitude), chemical composition, and exposure scenarios for a wide range of consumer products. In modeling indirect exposures from near-field sources SHEDS-HT employs a fugacity-based module to estimate concentrations in indoor environmental media. The concentration estimates, along with relevant exposure factors and human activity data, are then used by the model to rapidly generate probablistic population distributions of near-field indirect exposures via dermal. nondietary ingestion, and inhalation pathways. Pathway-specific estimates of near-field direct exposures from consumer products are also modeled. Population dietary exposures for a variety of chemicals found in foods are combined with the corresponding chemical-specific near-field exposure predictions to produce aggregate population exposure estimates. The estimated intake dose rates (mg/kg/day) for the 2507 chemical case-study spanned 13 orders of magnitude. SHEDS-HT successfully reproduced the pathway-specific exposure results of the higher-tier SHEDS-MM for a case-study pesticide and produced median intake doses significantly correlated (p<0.0001, R-2 = 0.39) with medians inferred using biomonitoring data for 39 chemicals from the National Health and Nutrition Examination Survey (NHANES). Based on the favorable performance of SHEDS-HT with respect to these initial evaluations, we believe this new tool will be useful for HT prediction of chemical exposure potential.
C1 [Isaacs, Kristin K.; Egeghy, Peter; Vallero, Daniel; Oezkaynak, Haluk] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA.
[Glen, W. Graham; Smith, Luther] Alion Sci & Technol, Durham, NC 27713 USA.
[Goldsmith, Michael-Rock] Chem Comp Grp, Montreal, PQ H3A 2R7, Canada.
[Brooks, Raina] US EPA, Res Triangle Pk, NC 27709 USA.
[Grulke, Christopher M.] Lockheed Martin, Res Triangle Pk, NC 27709 USA.
RP Isaacs, KK (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM isaacs.kristin@epa.gov
NR 66
TC 22
Z9 23
U1 3
U2 43
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12750
EP 12759
DI 10.1021/es502513w
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100033
PM 25222184
ER
PT J
AU Wambaugh, JF
Wang, A
Dionisio, KL
Frame, A
Egeghy, P
Judson, R
Setzer, RW
AF Wambaugh, John F.
Wang, Anran
Dionisio, Kathie L.
Frame, Alicia
Egeghy, Peter
Judson, Richard
Setzer, R. Woodrow
TI High Throughput Heuristics for Prioritizing Human Exposure to
Environmental Chemicals
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID RISK-ASSESSMENT; MODELS
AB The risk posed to human health by any of the thousands of untested anthropogenic chemicals in our environment is a function of both the hazard presented by the chemical and the extent of exposure. However, many chemicals lack estimates of exposure intake, limiting the understanding of health risks. We aim to develop a rapid heuristic method to determine potential human exposure to chemicals for application to the thousands of chemicals with little or not exposure data. We used Bayesian methodology to infer ranges of exposure consistent with biomarkers identified in urine samples from the U.S. population by the National Health and Nutrition Examination Survey (NHANES). We performed linear regression on inferred exposure for demographic subsets of NHANES demarked by age, gender, and weight using chemical descriptors and use information from multiple databases and structure-based calculators. Five descriptors are capable of explaining roughly 50% of the variability in geometric means across 106 NHANES chemicals for all the demographic groups, including children aged 6-11. We use these descriptors to estimate human exposure to 7968 chemicals, the majority of which have no other quantitative exposure prediction. For thousands of chemicals with no other information, this approach allows forecasting of average exposure intake of environmental chemicals.
C1 [Wambaugh, John F.; Wang, Anran; Frame, Alicia; Judson, Richard; Setzer, R. Woodrow] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Dionisio, Kathie L.; Egeghy, Peter] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Wang, Anran] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA.
[Wang, Anran; Frame, Alicia] Oak Ridge Inst Sci & Educ Grantee, Oak Ridge, TN 37831 USA.
RP Wambaugh, JF (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Wambaugh.john@epa.gov
OI Judson, Richard/0000-0002-2348-9633; Wambaugh, John/0000-0002-4024-534X
NR 25
TC 21
Z9 22
U1 5
U2 31
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12760
EP 12767
DI 10.1021/es503583j
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100034
PM 25343693
ER
PT J
AU Erdakos, GB
Bhave, PV
Pouliot, GA
Simon, H
Mathur, R
AF Erdakos, Garnet B.
Bhave, Prakash V.
Pouliot, George A.
Simon, Heather
Mathur, Rohit
TI Predicting the Effects of Nanoscale Cerium Additives in Diesel Fuel on
Regional-Scale Air Quality
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID RISK-ASSESSMENT; EMISSIONS; PARTICULATE; PARTICLES; OXIDATION; EXPOSURE;
ENGINES
AB Diesel vehicles are a major source of air pollutant emissions. Fuel additives containing nanoparticulate cerium (nCe) are currently being used in some diesel vehicles to improve fuel efficiency. These fuel additives also reduce fine particulate matter (PM2.5) emissions and alter the emissions of carbon monoxide (CO), nitrogen oxides (NOx), and hydrocarbon (HC) species, including several hazardous air pollutants (HAPs). To predict their net effect on regional air quality, we review the emissions literature and develop a multipollutant inventory for a hypothetical scenario in which nCe additives are used in all on-road and nonroad diesel vehicles. We apply the Community Multiscale Air Quality (CMAQ) model to a domain covering the eastern U.S. for a summer and a whiter period. Model calculations suggest modest decreases of average PM2.5 concentrations and relatively larger decreases in particulate elemental carbon. The nCe additives also have an effect on 8 h maximum ozone in summer. Variable effects on HAPs are predicted. The total U.S. emissions of fine-particulate cerium are estimated to increase 25-fold and result in elevated levels of airborne cerium (up to 22 ng/m(3)), which might adversely impact human health and the environment.
C1 [Erdakos, Garnet B.; Bhave, Prakash V.; Pouliot, George A.; Mathur, Rohit] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Simon, Heather] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Erdakos, GB (reprint author), Sonoma Technol Inc, 1455 N McDowell Blvd,Suite D, Petaluma, CA 94954 USA.
EM gerdakos@sonomatech.com
RI simon, heather/E-4392-2011
OI simon, heather/0000-0001-7254-3360
NR 39
TC 3
Z9 3
U1 1
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 4
PY 2014
VL 48
IS 21
BP 12775
EP 12782
DI 10.1021/es504050g
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AS7QC
UT WOS:000344449100036
PM 25271762
ER
PT J
AU Holman, E
Gray, G
AF Holman, Elizabeth
Gray, George
TI Setting Pesticide Reference Doses: A Retrospective Analysis Examining
Key Data and Choices
SO HUMAN AND ECOLOGICAL RISK ASSESSMENT
LA English
DT Article
DE risk assessment; reference dose; science policy; pesticides
ID SAFETY ASSESSMENT; TOXICITY; RISK; CHEMICALS; HAZARD; US
AB Toxicity tests are widely used to set acceptable levels of chemical exposure. Different organizations have identified a base set of tests specifying a mix of endpoints, durations, and species to be tested. A specific test and endpoint is chosen as the basis for calculation of human health risk values like reference doses (RfDs). This study empirically evaluates the data and choices made in setting acute and chronic RfDs for 352 conventional pesticides. The results suggest that for Acute, Acute-Female Specific, and Chronic RfDs one test is used far more than others. Ninety-six percent of the 116 Acute Female-Specific RfDs relied on a developmental toxicity test and 78% of Chronic RfDs used the chronic bioassay. Tests in rats were used far more often than other species in all RfD calculations. For all types of RfDs a total uncertainty factor of 100 was most common although values as low as 1 and as high as 3000 were seen. These results provide insights not only into the science policy frameworks used, but also into ways toxicity testing and risk assessment may be streamlined and made more efficient.
C1 [Holman, Elizabeth] US EPA, Off Pesticide Programs, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA.
[Holman, Elizabeth; Gray, George] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Environm & Occupat Hlth, Ctr Risk Sci & Publ Hlth, Washington, DC USA.
RP Holman, E (reprint author), US EPA, Off Pesticide Programs, Off Chem Safety & Pollut Prevent, Ariel Rios Bldg,1200 Penn Ave NW,Mail Code 7509P, Washington, DC 20460 USA.
EM Holman.Elizabeth@epamail.epa.gov
NR 36
TC 0
Z9 0
U1 0
U2 31
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1080-7039
EI 1549-7860
J9 HUM ECOL RISK ASSESS
JI Hum. Ecol. Risk Assess.
PD NOV 2
PY 2014
VL 20
IS 6
BP 1550
EP 1564
DI 10.1080/10807039.2013.879017
PG 15
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AE8QO
UT WOS:000334266600009
ER
PT J
AU Gladwell, W
Yost, O
Nelson, S
McCaw, Z
Gilmour, I
Ciencewicki, J
Kleeberger, S
AF Gladwell, Wesley, II
Yost, Oriana
Nelson, Spencer
McCaw, Zachary
Gilmour, Ian
Ciencewicki, Jonathan
Kleeberger, Steven
TI Differential Susceptibility to Diesel Exhaust Extract in Human
Lymphoblastoid Cell Lines
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Meeting Abstract
C1 [Gladwell, Wesley, II; Yost, Oriana; Nelson, Spencer; McCaw, Zachary; Ciencewicki, Jonathan; Kleeberger, Steven] NIEHS, Res Triangle Pk, NC USA.
[Gilmour, Ian] US EPA, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2014
VL 76
SU 1
MA 125
BP S61
EP S61
DI 10.1016/j.freeradbiomed.2014.10.368
PG 1
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CO9WA
UT WOS:000359525800145
ER
PT J
AU Verhein, KC
Nichols, JL
Panduri, V
Gladwell, W
Marzec, J
McCaw, Z
Reeves, N
Malphurs, J
Solomon, G
Wiltshire, T
Burkholder, A
Fargo, D
Bell, D
Van Houten, B
Kleeberger, SR
AF Verhein, Kirsten C.
Nichols, Jennifer L.
Panduri, Vijayalakshmi
Gladwell, Wesley
Marzec, Jacqui
McCaw, Zachary
Reeves, Nicole
Malphurs, Jason
Solomon, Greg
Wiltshire, Tim
Burkholder, Adam
Fargo, David
Bell, Douglas
Van Houten, Bennett
Kleeberger, Steven R.
TI Genetic Determinants of Oxidant-Induced Nuclear and Mitochondrial DNA
Lesions in a Neonatal Inbred Mouse Model of Acute Lung Injury
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Meeting Abstract
C1 [Verhein, Kirsten C.; Panduri, Vijayalakshmi; Gladwell, Wesley; Marzec, Jacqui; McCaw, Zachary; Reeves, Nicole; Malphurs, Jason; Solomon, Greg; Burkholder, Adam; Fargo, David; Bell, Douglas; Kleeberger, Steven R.] NIEHS, Res Triangle Pk, NC USA.
[Nichols, Jennifer L.] US EPA, Washington, DC USA.
[Wiltshire, Tim] Univ North Carolina Chapel Hill, Chapel Hill, NC USA.
[Van Houten, Bennett] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2014
VL 76
SU 1
MA 409
BP S167
EP S168
DI 10.1016/j.freeradbiomed.2014.10.058
PG 2
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CO9WA
UT WOS:000359525800428
ER
PT J
AU Wages, PA
Silbajoris, R
Bromberg, PA
Simmons, SO
Samet, JM
AF Wages, Phillip A.
Silbajoris, Robert
Bromberg, Philip A.
Simmons, Steven O.
Samet, James M.
TI Exploring the Role of H2O2 in Zinc-Induced Cellular Oxidative Effects
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Meeting Abstract
C1 [Wages, Phillip A.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Silbajoris, Robert; Samet, James M.] US EPA, EPHD, NHEERL, Washington, DC USA.
[Bromberg, Philip A.] Univ N Carolina, CEMALB, Chapel Hill, NC USA.
[Simmons, Steven O.] US EPA, ISTD, NHEERL, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2014
VL 76
SU 1
MA 377
BP S153
EP S153
DI 10.1016/j.freeradbiomed.2014.10.573
PG 1
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CO9WA
UT WOS:000359525800396
ER
PT J
AU Doa, M
Lewis, P
Canavan, S
Gonzalez, Y
AF Doa, M.
Lewis, P.
Canavan, S.
Gonzalez, Y.
TI ChemView: Making data on chemicals publicly available
SO PHYTOPATHOLOGY
LA English
DT Meeting Abstract
CT APS-CPS Joint Meeting
CY AUG 09-13, 2014
CL Minneapolis, MN
SP APS, CPS
C1 [Doa, M.; Lewis, P.; Canavan, S.; Gonzalez, Y.] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER PHYTOPATHOLOGICAL SOC
PI ST PAUL
PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA
SN 0031-949X
EI 1943-7684
J9 PHYTOPATHOLOGY
JI Phytopathology
PD NOV
PY 2014
VL 104
IS 11
SU 3
BP 33
EP 33
PG 1
WC Plant Sciences
SC Plant Sciences
GA AW5GG
UT WOS:000346303300188
ER
PT J
AU Browne, P
AF Browne, P.
TI EPA's Endocrine Disruptor Screening Program: Background and evaluation
of Tier 1 results from chemical case studies
SO PHYTOPATHOLOGY
LA English
DT Meeting Abstract
CT APS-CPS Joint Meeting
CY AUG 09-13, 2014
CL Minneapolis, MN
SP APS, CPS
C1 [Browne, P.] US EPA, Off Sci Coordinat & Policy, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER PHYTOPATHOLOGICAL SOC
PI ST PAUL
PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA
SN 0031-949X
EI 1943-7684
J9 PHYTOPATHOLOGY
JI Phytopathology
PD NOV
PY 2014
VL 104
IS 11
SU 3
BP 144
EP 144
PG 1
WC Plant Sciences
SC Plant Sciences
GA AW5GG
UT WOS:000346303301026
ER
PT J
AU Alexis, NE
Carlsten, C
AF Alexis, Neil E.
Carlsten, Chris
TI Interplay of air pollution and asthma immunopathogenesis: A focused
review of diesel exhaust and ozone
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Review
DE Diesel exhaust particles (DEP); Ozone; Innate immune response; Allergic
inflammation; Asthma
ID OBSTRUCTIVE PULMONARY-DISEASE; ANTIOXIDANT N-ACETYLCYSTEINE; DENDRITIC
CELL MATURATION; IN-VIVO; INFLAMMATORY RESPONSE; NEUTROPHIL RESPONSE;
CYTOKINE PRODUCTION; PARTICULATE MATTER; ALLERGIC-ASTHMA; IGE PRODUCTION
AB Controlled human exposure experiments with diesel exhaust particles (DEPs) and ozone serve to illustrate the important role pollutants play in modulating both allergic mechanisms and immune responses to affect the immunopathogenesis of airway diseases such as asthma. For DEP, evidence is stronger for the exacerbation of existing asthma rather than for the development of new disease. To the extent that this enhancement occurs, the augmentation of Th2-type immunity seems to be a common element. For ozone, neutrophilic inflammation, altered immune cell phenotype and function and oxidative stress are all marked responses that likely contribute to underlying immune-inflammatory features of asthma. Evidence is also emerging that unique gene signatures and epigenetic control of immune and inflammatory-based genes are playing important roles in the magnitude of the impact ozone is having on respiratory health. Indeed, the interplay between air pollutants such as DEP and ozone and asthma immunopathogenesis is an ongoing concern in terms of understanding how exposure to these agents can lead to worsening of disease. To this end, asthmatics may be pre-disposed to the deleterious effects of pollutants like ozone, having constitutively modified host defense functions and gene signatures. Although this review has utilized DEP and ozone as example pollutants, more research is needed to better understand the interplay between air pollution in general and asthma immumopathogenesis. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Alexis, Neil E.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Dept Pediat, Chapel Hill, NC 27599 USA.
[Carlsten, Chris] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1M9, Canada.
[Carlsten, Chris] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada.
RP Alexis, NE (reprint author), Univ N Carolina, US EPA, Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM Neil_Alexis@med.unc.edu
NR 62
TC 10
Z9 10
U1 1
U2 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD NOV
PY 2014
VL 23
IS 1
BP 347
EP 355
DI 10.1016/j.intimp.2014.08.009
PG 9
WC Immunology; Pharmacology & Pharmacy
SC Immunology; Pharmacology & Pharmacy
GA AX6FZ
UT WOS:000347019800045
PM 25194677
ER
PT J
AU Mitsch, WJ
Nedrich, SM
Harter, SK
Anderson, C
Nahlik, AM
Bernal, B
AF Mitsch, William J.
Nedrich, Sara M.
Harter, Sarah K.
Anderson, Christopher
Nahlik, Amanda M.
Bernal, Blanca
TI Sedimentation in created freshwater riverine wetlands: 15 years of
succession and contrast of methods
SO ECOLOGICAL ENGINEERING
LA English
DT Article
DE Freshwater marsh; Olentangy River Wetland Research Park; Sedimentation;
Erosion; Bioturbation; Horizon markers
ID SMALL CONSTRUCTED WETLANDS; RAPIDLY SUBSIDING WETLAND; FORESTED WETLAND;
SALT MARSHES; NUTRIENT ACCUMULATION; RIPARIAN WETLANDS; SOIL PARTICLES;
CANAL IMPACTS; UNITED-STATES; SELF-DESIGN
AB This study summarizes five separate sedimentation studies spanning 15 years (years 3-17 following wetland creation in 1994) of two 1 ha experimental flow-through wetlands. Included are methods and analyses of the most recent (2009-2010) comparative study that attempted to quantify both erosion and bioturbation processes. Depending on techniques used, two distinct types of sedimentation rates were estimated-gross and net sedimentation. Gross sedimentation in 2004-2005 (years 11 and 12) using sediment trap bottles was 45 kg m(-2) for 4 months during and after spring flood pulsing conditions in 2004 and 39 kg m(-2) for the same 4 months during and after steady flow conditions in 2005. Annual sediment accretion using feldspar and other horizon markers was 31.7 +/- 4.4 kg m(-2) yr(-1) (4.2 +/- 0.6 cm yr(-1)) in 1996 (year 3 after wetland creation) and 34.4 +/- 4.5 kg m(-2) yr(-1) (5.5 +/- 0.8 cm yr(-1)) in 2009 (year 16 after wetland creation). Net sedimentation using soil cores to estimate accumulation of sediments over antecedent soil horizon layers was 4.7 +/- 0.3 kg m(-2) yr(-1) (0.9 +/- 0.07 cm yr(-1)) in 2004 (year 11) and 6.0 +/- 0.4 kg m(-2) yr(-1) (0.9 +/- 0.06 cm yr(-1)) in 2009 (year 16). Net sedimentation, using estimates of sedimentation and erosion with the sediment erosion table (SET) method in 2009-2010 (years 16-17) was 3.9 +/- 6.1-9.0 kg m(-2) yr(-1) (1.3 +/- 0.8-1.4 cm yr(-1)). Bioturbation by macrofauna significantly decreased sedimentation rates during the 2009 (year 16) study. Spatial patterns, consistent among horizon marker and net sedimentation studies, showed that deep, open-water areas had higher rates of sedimentation than shallow areas with emergent vegetation, and that sedimentation rates were higher when closer to the inflow than at the outflow of these flow-through wetlands. Net sedimentation of these created riverine wetlands ranged from 1.2 cm/yr to 1.4 cm/yr, suggesting that these wetlands will accumulate about 30 cm of sediments in a little more than two decades. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Mitsch, William J.] Florida Gulf Coast Univ, Naples, FL 34112 USA.
[Nedrich, Sara M.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA.
[Harter, Sarah K.] Ohio EPA Southeast Dist Off, Logan, OH 43138 USA.
[Anderson, Christopher] Auburn Univ, Sch Forestry & Wildlife Sci, Auburn, AL 36849 USA.
[Nahlik, Amanda M.] US EPA, Western Ecol Div, Corvallis, OR 97333 USA.
[Bernal, Blanca] Smithsonian Environm Res Ctr, Biogeochem Lab, Edgewater, MD 21037 USA.
RP Mitsch, WJ (reprint author), Florida Gulf Coast Univ, Everglades Wetland Res Pk, Naples, FL 34112 USA.
EM wmitsch@fgcu.edu
OI Mitsch, William/0000-0001-8348-3172
FU Society of Wetland Scientists; OARCD graduate research enhancement;
Payne; SEEDS grants; USDA NRI CSREES [2002-35102-13518]; USEPA from
Cincinnati OH [EM83329801-0]; Gulf of Mexico Program [MX95413108-0];
National Science Foundation [CBET-1033451, CBET-0829026]; Sigma Xi (Ohio
State Chapter)
FX Thanks to the many wetlanders who helped the authors in the four
separate studies summarized here; you are too numerous to mention but
your contributions to wetland science remain important. This research
was supported by several sources including Society of Wetland Scientists
student support, OARCD graduate research enhancement, Payne, and SEEDS
grants, USDA NRI CSREES Grant no. 2002-35102-13518, USEPA
Agreements-EM83329801-0 from Cincinnati OH and MX95413108-0 from Gulf of
Mexico Program, the National Science Foundation (CBET-1033451 and
CBET-0829026), and a Sigma Xi (Ohio State Chapter) Grant-In-Aid of
Research award. Thanks to Anne Mischo for an illustration on a short
time frame.
NR 55
TC 3
Z9 3
U1 4
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-8574
EI 1872-6992
J9 ECOL ENG
JI Ecol. Eng.
PD NOV
PY 2014
VL 72
BP 25
EP 34
DI 10.1016/j.ecoleng.2014.09.116
PG 10
WC Ecology; Engineering, Environmental; Environmental Sciences
SC Environmental Sciences & Ecology; Engineering
GA AW6NY
UT WOS:000346387300003
ER
PT J
AU Stauffer, BA
Goes, JI
Mckee, KT
Gomes, HD
Stabeno, PJ
AF Stauffer, Beth A.
Goes, Joaquim I.
Mckee, Kali T.
Gomes, Helga do Rosario
Stabeno, Phyllis J.
TI Comparison of spring-time phytoplankton community composition in two
cold years from the western Gulf of Alaska into the southeastern Bering
Sea
SO DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY
LA English
DT Article
DE Community composition; Phytoplankton; Climatic changes; Food webs;
Marine ecology
ID NORTH PACIFIC; FOOD WEBS; ECOSYSTEM; SHELF; VARIABILITY; ZOOPLANKTON;
TEMPERATURE; PHAEOCYSTIS; CLIMATE; ICE
AB The Bering Sea is a highly productive ecosystem providing the main oceanographic connection between the North Pacific and Arctic oceans. The atmospheric connection with the Arctic Ocean leads to seasonal sea ice formation in the Bering Sea, the areal extent and timing of retreat of which have important implications for primary productivity and phytoplankton community composition in this region. Hydrographic data from cruises and satellite sea ice and sea surface temperature data in spring 2011 and 2012 suggest classification of these years as relatively warmer and colder years, respectively. Locations in the western Gulf of Alaska (Pavlof Bay), at the north end of an eastern pass through the Aleutian Islands (Unimak Pass), and on the continental shelf of the Bering Sea (M2) were visited in both years. Stratification was apparent on the shelf in 2012, while the water column was comparatively well-mixed at other locations in both years. Phytoplankton biomass was highest in 2011 overall and specifically on the shelf in both years, while minimal biomass was measured within the well-mixed Unimak Pass in 2012. Surface phytoplankton size distributions included substantial contributions of picoplankton (< 3 mu m) in 2011 (21-35%), while micro-(20-200 mu m) and nanoplankton (3-20 mu m) comprised 79% and 95% of biomass in Pavlof Bay and at M2, respectively, in 2012. Analyses of similarity revealed spatial variability in the phytoplankton assemblages within each year (2011: R=0.588, p < 0.004; 2012: R=0.646, p < 0.004). Additionally, between-year variability had a strong and significant effect on differences between assemblages across all locations (R=0.579, p < 0.0003), likely masking differences between sites when years were grouped (R=0.134, p < 0.079). These differences were likely driven by the dominance (up to 75% in Unimak Pass) of the colonial prymnesiophyte Phaeocystis sp. at all sites in 2011, resulting in reduced community diversity, compared to more widespread abundance of large diatoms of the genera Thalassiosira, Thalassiothrix, and Chaetoceros in 2012. The current study shows that within-regime differences in phytoplankton community composition between years can be almost as great as that between locations with vastly different oceanographic settings. High between-and multi-year variability may combine with a potential overall decline in sea ice in the Bering Sea to produce significant changes in the productive base of the food web with potential cascading effects on higher, economically and ecologically important trophic levels. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Stauffer, Beth A.; Goes, Joaquim I.; Mckee, Kali T.; Gomes, Helga do Rosario] Columbia Univ, Dept Biol & Paleo Environm, Lamont Doherty Earth Observ, Palisades, NY 10964 USA.
[Stabeno, Phyllis J.] NOAA, Pacific Marine Environm Lab, Seattle, WA 98115 USA.
RP Stauffer, BA (reprint author), US EPA, 1200 Pennsylvania Ave, Washington, DC 20460 USA.
EM stauffer@ldeo.columbia.edu
FU National Aeronautics and Space Administration [NNX10AP10G, NNX11AP28G];
National Oceanic and Atmospheric Administration; Eco-FOCI project
FX This is BEST-BSIERP publication number 130. This work was supported by
the National Aeronautics and Space Administration (Grants # NNX10AP10G
and NNX11AP28G), and space aboard the R/V Oscar Dyson was generously
provided by the National Oceanic and Atmospheric Administration in
concert with the Eco-FOCI project. The authors thank K. Keebler for
field assistance, J.M. Rose
NR 54
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U1 1
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0967-0645
EI 1879-0100
J9 DEEP-SEA RES PT II
JI Deep-Sea Res. Part II-Top. Stud. Oceanogr.
PD NOV
PY 2014
VL 109
SI SI
BP 57
EP 70
DI 10.1016/j.dsr2.2014.03.007
PG 14
WC Oceanography
SC Oceanography
GA AU7UZ
UT WOS:000345807900006
ER
PT J
AU Milanovich, JR
Hopton, ME
AF Milanovich, Joseph R.
Hopton, Matthew E.
TI Stoichiometry of a semi-aquatic plethodontid salamander: Intraspecific
variation due to location, size and diet
SO INTEGRATIVE ZOOLOGY
LA English
DT Article
DE carbon; Eurycea cirrigera; nitrogen; phosphorus; stream
ID ECOSYSTEM PROCESSES; HEADWATER STREAMS; TROPICAL STREAM;
STABLE-ISOTOPES; MIXING MODELS; NEW-HAMPSHIRE; NUTRIENT; POPULATIONS;
AMPHIBIANS; DYNAMICS
AB Ecological stoichiometry provides a framework to investigate an organism's relationship to nutrient cycles. An organism's stoichiometry is thought to constrain its contribution to nutrient cycles (recycling or storage), and to limit its growth and reproduction. Factors that influence the stoichiometry of a consumer are largely unstudied, but what is known is that consumer stoichiometry is influenced by the elemental requirements of the consumer (e.g. for growth, reproduction and cell maintenance) and the availability of elements. We examined whole-body stoichiometry of larval southern two-lined salamanders (Eurycea cirrigera) and described the influence of location, body size, stoichiometry of diet items, and environmental nutrient supply on whole-body stoichiometry. Mean composition of phosphorous was 2.6%, nitrogen was 11.3%, and carbon was 39.6%, which are similar for other aquatic vertebrate taxa. The most significant predictor of whole-body stoichiometry was the site where the samples were collected, which was significant for each nutrient and nutrient ratio. Body size and stoichiometry of diet items were also predictors of Eurycea cirrigera stoichiometry. Our study suggests that spatial differences in environmental nutrient supply have a stronger influence on consumer whole-body stoichiometry among similar-sized larvae compared to life history traits, such as body size or diet.
C1 [Milanovich, Joseph R.; Hopton, Matthew E.] US EPA, Off Res & Dev, Sustainable Technol Div, Natl Risk Management Res Lab,Sustainable Environm, Cincinnati, OH 45068 USA.
RP Hopton, ME (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div,Clean Proc Branch, 26 W Martin Luther King Dr, Cincinnati, OH 45068 USA.
EM hopton.matthew@epa.gov
OI Hopton, Matt/0000-0001-7962-6820
NR 49
TC 1
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U1 4
U2 22
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1749-4877
EI 1749-4869
J9 INTEGR ZOOL
JI Integr. Zool.
PD NOV
PY 2014
VL 9
IS 5
BP 613
EP 622
DI 10.1111/1749-4877.12114
PG 10
WC Zoology
SC Zoology
GA AU6EG
UT WOS:000345695200007
PM 25236804
ER
PT J
AU Wetmore, BA
Allen, B
Clewell, HJ
Parker, T
Wambaugh, JF
Almond, LM
Sochaski, MA
Thomas, RS
AF Wetmore, Barbara A.
Allen, Brittany
Clewell, Harvey J., III
Parker, Timothy
Wambaugh, John F.
Almond, Lisa M.
Sochaski, Mark A.
Thomas, Russell S.
TI Incorporating Population Variability and Susceptible Subpopulations into
Dosimetry for High-Throughput Toxicity Testing
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE In vitro in vivo extrapolation; population variability; toxicokinetics;
reaction phenotyping; dosimetry; risk assessment
ID STATE PLASMA-CONCENTRATIONS; PHARMACOKINETIC-PHARMACODYNAMIC INTERFACE;
HUMAN LIVER-MICROSOMES; AGE-RELATED-CHANGES; IN-VITRO;
UDP-GLUCURONOSYLTRANSFERASES; RISK-ASSESSMENT; DEVELOPMENTAL EXPRESSION;
ENVIRONMENTAL CHEMICALS; EXTRAPOLATION FACTORS
AB Momentum is growing worldwide to use in vitro high-throughput screening (HTS) to evaluate human health effects of chemicals. However, the integration of dosimetry into HTS assays and incorporation of population variability will be essential before its application in a risk assessment context. Previously, we employed in vitro hepatic metabolic clearance and plasma protein binding data with in vitro in vivo extrapolation (IVIVE) modeling to estimate oral equivalent doses, or daily oral chemical doses required to achieve steady-state blood concentrations (C-ss) equivalent to media concentrations having a defined effect in an in vitro HTS assay. In this study, hepatic clearance rates of selected ToxCast chemicals were measured in vitro for 13 cytochrome P450 and five uridine 5'-diphospho-glucuronysyltransferase isozymes using recombinantly expressed enzymes. The isozyme-specific clearance rates were then incorporated into an IVIVE model that captures known differences in isozyme expression across several life stages and ethnic populations. Comparison of the median C-ss for a healthy population against the median or the upper 95th percentile for more sensitive populations revealed differences of 1.3- to 4.3-fold or 3.1- to 13.1-fold, respectively. Such values may be used to derive chemical-specific human toxicokinetic adjustment factors. The IVIVE model was also used to estimate subpopulation-specific oral equivalent doses that were directly compared with subpopulation-specific exposure estimates. This study successfully combines isozyme and physiologic differences to quantitate subpopulation pharmacokinetic variability. Incorporation of these values with dosimetry and in vitro bioactivities provides a viable approach that could be employed within a high-throughput risk assessment framework.
C1 [Wetmore, Barbara A.; Allen, Brittany; Clewell, Harvey J., III; Parker, Timothy; Sochaski, Mark A.; Thomas, Russell S.] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA.
[Wambaugh, John F.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Almond, Lisa M.] Simcyp Ltd, Blades Enterprise Ctr, Sheffield S2 4SU, S Yorkshire, England.
RP Wetmore, BA (reprint author), Hamner Inst Hlth Sci, 6 Davis Dr,POB 12137, Res Triangle Pk, NC 27709 USA.
EM bwetmore@thehamner.org
OI Thomas, Russell/0000-0002-2340-0301; Wambaugh, John/0000-0002-4024-534X
FU American Chemistry Council's Long-Range Research Initiative; Agilent
Thought Leader Award, Agilent Foundation
FX American Chemistry Council's Long-Range Research Initiative; Agilent
Thought Leader Award, Agilent Foundation.
NR 91
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U1 4
U2 24
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD NOV
PY 2014
VL 142
IS 1
BP 210
EP 224
DI 10.1093/toxsci/kfu169
PG 15
WC Toxicology
SC Toxicology
GA AU8IT
UT WOS:000345840600019
PM 25145659
ER
PT J
AU Breen, MS
Burke, JM
Batterman, SA
Vette, AF
Godwin, C
Croghan, CW
Schultz, BD
Long, TC
AF Breen, Michael S.
Burke, Janet M.
Batterman, Stuart A.
Vette, Alan F.
Godwin, Christopher
Croghan, Carry W.
Schultz, Bradley D.
Long, Thomas C.
TI Modeling Spatial and Temporal Variability of Residential Air Exchange
Rates for the Near-Road Exposures and Effects of Urban Air Pollutants
Study (NEXUS)
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article; Proceedings Paper
CT Conference on Integrated Science and Knowledge Co-Production for
Ecosystems and Human Well-Being
CY MAY 25-31, 2014
CL Villa Vigoni, ITALY
DE air exchange rate modeling; air pollution; health; exposure
ID CENTRAL NORTH-CAROLINA; INFILTRATION; JACKKNIFE; INDOOR; ASSESSMENTS;
BOOTSTRAP; ERROR; PM2.5; TIME
AB Air pollution health studies often use outdoor concentrations as exposure surrogates. Failure to account for variability of residential infiltration of outdoor pollutants can induce exposure errors and lead to bias and incorrect confidence intervals in health effect estimates. The residential air exchange rate (AER), which is the rate of exchange of indoor air with outdoor air, is an important determinant for house-to-house (spatial) and temporal variations of air pollution infiltration. Our goal was to evaluate and apply mechanistic models to predict AERs for 213 homes in the Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS), a cohort study of traffic-related air pollution exposures and respiratory effects in asthmatic children living near major roads in Detroit, Michigan. We used a previously developed model (LBL), which predicts AER from meteorology and questionnaire data on building characteristics related to air leakage, and an extended version of this model (LBLX) that includes natural ventilation from open windows. As a critical and novel aspect of our AER modeling approach, we performed a cross validation, which included both parameter estimation (i.e., model calibration) and model evaluation, based on daily AER measurements from a subset of 24 study homes on five consecutive days during two seasons. The measured AER varied between 0.09 and 3.48 h(-1) with a median of 0.64 h(-1). For the individual model-predicted and measured AER, the median absolute difference was 29% (0.19 h(-1)) for both the LBL and LBLX models. The LBL and LBLX models predicted 59% and 61% of the variance in the AER, respectively. Daily AER predictions for all 213 homes during the three year study (2010-2012) showed considerable house-to-house variations from building leakage differences, and temporal variations from outdoor temperature and wind speed fluctuations. Using this novel approach, NEXUS will be one of the first epidemiology studies to apply calibrated and home-specific AER models, and to include the spatial and temporal variations of AER for over 200 individual homes across multiple years into an exposure assessment in support of improving risk estimates.
C1 [Breen, Michael S.; Burke, Janet M.; Godwin, Christopher; Croghan, Carry W.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Batterman, Stuart A.; Godwin, Christopher] Univ Michigan, Ann Arbor, MI 48109 USA.
[Vette, Alan F.] US EPA, Immediate Off Assistant Administrator, Res Triangle Pk, NC 27711 USA.
[Long, Thomas C.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Breen, MS (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM breen.michael@epa.gov; burke.janet@epa.gov; stuartb@umich.edu;
vette.alan@epa.gov; ccgodwin@umich.edu; croghan.carry@epa.gov;
schultz_brad@yahoo.com; long.tom@epa.gov
FU U.S. Environmental Protection Agency through Office of Research and
Development [R834117, EP-D-10-070]; NIEHS [5-R01-ES014677-02, R01
ES016769-01]
FX The NEXUS study involves a community-based participatory research
partnership, which was conducted with input from several partners,
including the Community Action Against Asthma (CAAA) Steering Committee.
We thank the CAAA its member organizations including the Arab Community
Center for Economic and Social Services, Community Health and Social
Services Center Inc., Detroit Hispanic Development Corporation,
Detroiters Working for Environmental Justice, Friends of Parkside,
Detroit Department of Health and Wellness Promotion, Latino Family
Services, Southwest Detroit Environmental Vision, Warren/Conner
Development Corporation, the University of Michigan School of Medicine,
the University of Michigan School of Public Health, and an independent
community activist. We also thank Thomas Robins and Toby Lewis, and our
field laboratory and data management staff including Leonard Brakefield,
Sonya Grant, Laprisha Berry Vaughn, Graciela Menz, and Irme Cuadros
(University of Michigan). We also thank Gary Norris for his help with
the study design, and Robert Devlin and Michelle Oakes (U.S.
Environmental Protection Agency) for their reviews and helpful
suggestions. The U.S. Environmental Protection Agency through its Office
of Research and Development partially funded the research under
cooperative agreement R834117 (University of Michigan) and contract
EP-D-10-070 (Alion Science and Technology). Although this manuscript was
reviewed by the U.S. Environmental Protection Agency and approved for
publication, it may not necessarily reflect official Agency policy. The
study was conducted as part of NIEHS grants 5-R01-ES014677-02 and R01
ES016769-01. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 38
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U1 2
U2 21
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2014
VL 11
IS 11
BP 11481
EP 11504
DI 10.3390/ijerph111111481
PG 24
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AU3RT
UT WOS:000345532000028
PM 25386953
ER
PT J
AU Oakes, MM
Baxter, LK
Duvall, RM
Madden, M
Xie, MJ
Hannigan, MP
Peel, JL
Pachon, JE
Balachandran, S
Russell, A
Long, TC
AF Oakes, Michelle M.
Baxter, Lisa K.
Duvall, Rachelle M.
Madden, Meagan
Xie, Mingjie
Hannigan, Michael P.
Peel, Jennifer L.
Pachon, Jorge E.
Balachandran, Siv
Russell, Armistead
Long, Thomas C.
TI Comparing Multipollutant Emissions-Based Mobile Source Indicators to
Other Single Pollutant and Multipollutant Indicators in Different Urban
Areas
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE multipollutant; air pollution; exposure metrics; source apportionment;
mobile sources; emissions-based indicators
ID POSITIVE MATRIX FACTORIZATION; SEMIVOLATILE ORGANIC-COMPOUNDS;
AIR-QUALITY MANAGEMENT; SOURCE-APPORTIONMENT; TIME-SERIES; PARTICULATE
MATTER; AMBIENT AIR; PM2.5 CHARACTERIZATION; SPECIATION METHODS;
MEASUREMENT ERROR
AB A variety of single pollutant and multipollutant metrics can be used to represent exposure to traffic pollutant mixtures and evaluate their health effects. Integrated mobile source indicators (IMSIs) that combine air quality concentration and emissions data have recently been developed and evaluated using data from Atlanta, Georgia. IMSIs were found to track trends in traffic-related pollutants and have similar or stronger associations with health outcomes. In the current work, we apply IMSIs for gasoline, diesel and total (gasoline + diesel) vehicles to two other cities (Denver, Colorado and Houston, Texas) with different emissions profiles as well as to a different dataset from Atlanta. We compare spatial and temporal variability of IMSIs to single-pollutant indicators (carbon monoxide (CO), nitrogen oxides (NOx) and elemental carbon (EC)) and multipollutant source apportionment factors produced by Positive Matrix Factorization (PMF). Across cities, PMF-derived and IMSI gasoline metrics were most strongly correlated with CO (r = 0.31-0.98), while multipollutant diesel metrics were most strongly correlated with EC (r = 0.80-0.98). NOx correlations with PMF factors varied across cities (r = 0.29-0.67), while correlations with IMSIs were relatively consistent (r = 0.61-0.94). In general, single-pollutant metrics were more correlated with IMSIs (r = 0.58-0.98) than with PMF-derived factors (r = 0.07-0.99). A spatial analysis indicated that IMSIs were more strongly correlated (r > 0.7) between two sites in each city than single pollutant and PMF factors. These findings provide confidence that IMSIs provide a transferable, simple approach to estimate mobile source air pollution in cities with differing topography and source profiles using readily available data.
C1 [Oakes, Michelle M.; Madden, Meagan; Long, Thomas C.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Oakes, Michelle M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA.
[Baxter, Lisa K.; Duvall, Rachelle M.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA.
[Xie, Mingjie; Hannigan, Michael P.] Univ Colorado, Coll Engn & Appl Sci, Dept Mech Engn, Boulder, CO 80309 USA.
[Xie, Mingjie] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
[Peel, Jennifer L.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
[Pachon, Jorge E.] La Salle Univ, Program Environm Engn, Bogota, CO USA.
[Balachandran, Siv; Russell, Armistead] Georgia Inst Technol, Dept Civil & Environm Engn, Atlanta, GA 30332 USA.
[Balachandran, Siv] Union Concerned Scientists, Washington, DC 20006 USA.
RP Oakes, MM (reprint author), US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
EM mmoakes17@gmail.com; baxter.lisa@epa.gov; duvall.rachelle@epa.gov;
meagankmadden@gmail.com; mingjie.xie@colorado.edu;
hannigan@colorado.edu; jennifer.peel@colostate.edu;
jpachon@unisalle.edu.co; siv@gatech.edu; ted.russell@ce.gatech.edu;
long.tom@epa.gov
FU Research Participation Program in the National Center for Environmental
Assessment, Office of Research and Development, U.S. Environmental
Protection Agency
FX The authors wish to thank Michael Breen, Steven J. Dutton, Jennifer
Richmond-Bryant, Reeder Sams, and John Vandenberg for their helpful
comments in review of this manuscript. The authors also wish to thank
Alison Eyth and Adam Reff at the U.S. Environmental Protection Agency
for their help retrieving mobile source emissions data. MMO was
supported by an appointment to the Research Participation Program in the
National Center for Environmental Assessment, Office of Research and
Development, U.S. Environmental Protection Agency, administered by the
Oak Ridge Institute for Science and Education (ORISE) through an
interagency agreement between the U.S. Department of Energy and
Environmental Protection Agency. Disclaimer: The views expressed are
those of the authors and do not necessarily reflect the views or
policies of the U.S. Environmental Protection Agency.
NR 38
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U1 3
U2 30
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2014
VL 11
IS 11
BP 11727
EP 11752
DI 10.3390/ijerph111111727
PG 26
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA AU3RT
UT WOS:000345532000044
PM 25405595
ER
PT J
AU Brooks, JR
Gibson, JJ
Birks, SJ
Weber, MH
Rodecap, KD
Stoddard, JL
AF Brooks, J. Renee
Gibson, John J.
Birks, S. Jean
Weber, Marc H.
Rodecap, Kent D.
Stoddard, John L.
TI Stable isotope estimates of evaporation : inflow and water residence
time for lakes across the United States as a tool for national lake
water quality assessments
SO LIMNOLOGY AND OCEANOGRAPHY
LA English
DT Article
ID PHYTOPLANKTON FUNCTIONAL-GROUPS; METEORIC PRECIPITATION; SIZE
DISTRIBUTION; NITROGEN REMOVAL; LAND-USE; RESERVOIRS; HYDROGEN; CLIMATE;
BALANCE; CANADA
AB We used water delta H-2 and delta O-18 from ca. 1000 lakes sampled in the 2007 U.S. Environmental Protection Agency's National Lakes Assessment (NLA) to assess two hydrological variables-evaporation as a percentage of inflow (E : I) and water residence time (tau) for summer 2007. Using a population survey design, sampled lakes were distributed across the conterminous U.S., and results were scaled to the inference population (similar to 50,000 U.S. lakes). These hydrologic variables were related to lake nutrients and biological condition to illustrate their usefulness in national water quality monitoring efforts. For 50% of lakes, evaporation was, 25% of inflow, with values ranging up to 113% during the 2007 summer. Residence time was, 0.52 yr for half of the lakes and, 1.12 yr for 75% of lakes. Categorizing lakes by flow regime, 66.1% of lakes were flow-though lakes (60% or more of the water flows through the lake, E : I < 0.4), 33.6% were restricted-basin lakes (40% or more of the lake inflow evaporates, 0.4 < E: I < 1), and < 0.3% were closed basin (all water entering the lake leaves through evaporation, E : I > 1). While climate patterns drove some of the spatial patterns of E : I and tau, variation in lake depth and watershed size (influencing precipitation volume) were also significant drivers. Lake hydrochemistry was strongly correlated to E: I and more weakly related to tau. Lakes in poor biological condition (based on a predictive model of planktonic taxa) were significantly more evaporated than lakes in good biological condition.
C1 [Brooks, J. Renee; Weber, Marc H.; Rodecap, Kent D.; Stoddard, John L.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Gibson, John J.] Alberta Innovates Technol Futures, Victoria, BC, Canada.
[Birks, S. Jean] Alberta Innovates Technol Futures, Calgary, AB, Canada.
RP Brooks, JR (reprint author), US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
EM Brooks.ReneeJ@epa.gov
OI Brooks, Renee/0000-0002-5008-9774; Stoddard, John/0000-0002-2537-6130;
Weber, Marc/0000-0002-9742-4744
FU U.S. EPA
FX This work was supported by the U.S. EPA. This manuscript has been
subjected to the U.S. EPA's peer and administrative review, and it has
been approved for publication as a U.S. EPA document. Mention of trade
names or commercial products does not constitute endorsement or
recommendation for use.
NR 58
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U1 9
U2 44
PU AMER SOC LIMNOLOGY OCEANOGRAPHY
PI WACO
PA 5400 BOSQUE BLVD, STE 680, WACO, TX 76710-4446 USA
SN 0024-3590
EI 1939-5590
J9 LIMNOL OCEANOGR
JI Limnol. Oceanogr.
PD NOV
PY 2014
VL 59
IS 6
BP 2150
EP 2165
DI 10.4319/lo.2014.59.6.2150
PG 16
WC Limnology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA AU2QK
UT WOS:000345462700027
ER
PT J
AU McDonald, CP
Lottig, NR
Stoddard, JL
Herlihy, AT
Lehmann, S
Paulsen, SG
Peck, DV
Pollard, AI
Stevenson, RJ
AF McDonald, Cory P.
Lottig, Noah R.
Stoddard, John L.
Herlihy, Alan T.
Lehmann, Sarah
Paulsen, Steven G.
Peck, David V.
Pollard, Amina I.
Stevenson, R. Jan
TI Comment on Bachmann et al. (2013): A nonrepresentative sample cannot
describe the extent of cultural eutrophication of natural lakes in the
United States
SO LIMNOLOGY AND OCEANOGRAPHY
LA English
DT Article
ID FRESH-WATER; ECOSYSTEMS; PHOSPHORUS
C1 [McDonald, Cory P.] Wisconsin Dept Nat Resources, Madison, WI 53707 USA.
[Lottig, Noah R.] Univ Wisconsin, Trout Lake Res Stn, Boulder Jct, WI USA.
[Stoddard, John L.; Paulsen, Steven G.; Peck, David V.] US EPA, Western Ecol Div, Corvallis, OR USA.
[Herlihy, Alan T.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Lehmann, Sarah; Pollard, Amina I.] US EPA, Off Water, Monitoring Branch, Washington, DC 20460 USA.
[Stevenson, R. Jan] Michigan State Univ, E Lansing, MI 48824 USA.
RP McDonald, CP (reprint author), Wisconsin Dept Nat Resources, Madison, WI 53707 USA.
EM Cory.McDonald@wisconsin.gov
OI Stoddard, John/0000-0002-2537-6130; McDonald, Cory/0000-0002-1208-8471
FU Wisconsin Department of Natural Resources and the National Science
Foundation; North Temperate Lakes Long-Term Ecological Research
(Division of Environmental Biology) [DEB-0822700]; MacroSystems Biology
program (Emerging Frontiers) [EF1065818]
FX We thank the U.S. Environmental Protection Agency for making the
National Lakes Assessment data freely available, and Roger Bachmann for
sharing his working dataset. We acknowledge input provided by Lester
Yuan, Steve Carpenter, Tim Kratz, Patricia Soranno, and Emily Stanley on
early versions of this manuscript. We also thank Roger Bachmann and two
anonymous reviewers for their helpful comments. The information in this
document has been funded in part by the U.S. Environmental Protection
Agency. It has been subjected to review by the National Health and
Environmental Effects Research Laboratory and approved for publication.
This work was also supported by the Wisconsin Department of Natural
Resources and the National Science Foundation, North Temperate Lakes
Long-Term Ecological Research (Division of Environmental Biology,
DEB-0822700) and MacroSystems Biology program (Emerging Frontiers,
EF1065818).
NR 13
TC 2
Z9 2
U1 0
U2 14
PU AMER SOC LIMNOLOGY OCEANOGRAPHY
PI WACO
PA 5400 BOSQUE BLVD, STE 680, WACO, TX 76710-4446 USA
SN 0024-3590
EI 1939-5590
J9 LIMNOL OCEANOGR
JI Limnol. Oceanogr.
PD NOV
PY 2014
VL 59
IS 6
BP 2226
EP 2230
DI 10.4319/lo.2014.59.6.2226
PG 5
WC Limnology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA AU2QK
UT WOS:000345462700032
ER
PT J
AU Wu, QS
Lane, C
Liu, HX
AF Wu, Qiusheng
Lane, Charles
Liu, Hongxing
TI An Effective Method for Detecting Potential Woodland Vernal Pools Using
High-Resolution LiDAR Data and Aerial Imagery
SO REMOTE SENSING
LA English
DT Article
DE geographically isolated wetlands; seasonal wetlands; depression
analysis; Massachusetts
ID GEOGRAPHICALLY ISOLATED WETLANDS; SOUTHERN NEW-ENGLAND; WATER INDEX
NDWI; UNITED-STATES; CONSERVATION; LANDSCAPE; CONNECTIVITY; DEPRESSIONS;
DYNAMICS; MODELS
AB Effective conservation of woodland vernal pools-important components of regional amphibian diversity and ecosystem services-depends on locating and mapping these pools accurately. Current methods for identifying potential vernal pools are primarily based on visual interpretation and digitization of aerial photographs, with variable accuracy and low repeatability. In this paper, we present an effective and efficient method for detecting and mapping potential vernal pools using stochastic depression analysis with additional geospatial analysis. Our method was designed to take advantage of high-resolution light detection and ranging (LiDAR) data, which are becoming increasingly available, though not yet frequently employed in vernal pool studies. We successfully detected more than 2000 potential vernal pools in a similar to 150 km(2) study area in eastern Massachusetts. The accuracy assessment in our study indicated that the commission rates ranged from 2.5% to 6.0%, while the proxy omission rate was 8.2%, rates that are much lower than reported errors of previous vernal pool studies conducted in the northeastern United States. One significant advantage of our semi-automated approach for vernal pool identification is that it may reduce inconsistencies and alleviate repeatability concerns associated with manual photointerpretation methods. Another strength of our strategy is that, in addition to detecting the point-based vernal pool locations for the inventory, the boundaries of vernal pools can be extracted as polygon features to characterize their geometric properties, which are not available in the current statewide vernal pool databases in Massachusetts.
C1 [Wu, Qiusheng] US EPA, Dynamac Corp, Cincinnati, OH 45268 USA.
[Lane, Charles] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Wu, Qiusheng; Liu, Hongxing] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA.
RP Wu, QS (reprint author), US EPA, Dynamac Corp, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Wu.Qiusheng@epa.gov; Lane.Charles@epa.gov; Hongxing.Liu@uc.edu
RI Wu, Qiusheng/C-7976-2016
OI Wu, Qiusheng/0000-0001-5437-4073
NR 59
TC 12
Z9 12
U1 5
U2 24
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-4292
J9 REMOTE SENS-BASEL
JI Remote Sens.
PD NOV
PY 2014
VL 6
IS 11
BP 11444
EP 11467
DI 10.3390/rs61111444
PG 24
WC Remote Sensing
SC Remote Sensing
GA AU3RG
UT WOS:000345530700053
ER
PT J
AU Consoer, DM
Hoffman, AD
Fitzsimmons, PN
Kosian, PA
Nichols, JW
AF Consoer, Daniel M.
Hoffman, Alex D.
Fitzsimmons, Patrick N.
Kosian, Patricia A.
Nichols, John W.
TI Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout
(Oncorhynchus mykiss)
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Perfluoroalkyl acid; Perfluorooctanoate; Rainbow trout; Renal
elimination; Tissue distribution; Membrane transporter
ID ORGANIC ANION TRANSPORTER; CHAIN PERFLUORINATED ACIDS; TANDEM
MASS-SPECTROMETRY; PERFLUOROALKYL ACIDS; RENAL EXCRETION;
P-GLYCOPROTEIN; DEVELOPMENTAL TOXICITY; EFFLUX TRANSPORTERS; TISSUE
DISTRIBUTION; WINTER FLOUNDER
AB Rainbow trout (Oncorhynchus mykiss) confined to respirometer-metabolism chambers were dosed with perfluorooctanoate (PFOA) by intra-arterial (i.a.) injection and sampled to obtain concentration time-course data for plasma, urine, and expired water. The data were then analyzed by compartmental modeling to estimate rates of renal and branchial clearance. Averaged across all animals, the renal clearance rate (1.35 mL/h/kg) was more than ten times greater than the branchial clearance rate (0.12 mL/h/kg). The average whole-body elimination half-life was 12.6 d, which is somewhat longer than values obtained in previous studies with smaller trout. The tissue distribution of PFOA was assessed by collecting tissues at the end of chambered exposures and in a separate tissue time-course experiment. From the time-course study it appeared that an internal steady-state was established within 24 h of i.a. injection. Consistent with previous studies, the rank order of PFOA concentration in tissues at steady state was: plasma > liver> kidney > muscle. In a second set of chambered experiments, fish were exposed to PFOA in water to determine the rate of branchial uptake. Branchial uptake rates were too low to assess directly by measuring PFOA concentrations in inspired and expired water. Uptake rate constants (mean 0.19 L/d/kg; 0.1% uptake efficiency) were therefore estimated by compartmental modeling using plasma concentration time-course data and model parameters derived from the elimination experiments. It is clear from this effort that elimination of PFOA by trout occurs primarily via the renal route. This finding is consistent with numerous studies of mammals and suggests that trout possess membrane transporters that facilitate the movement of PFOA from plasma to urine. Published by Elsevier B.V.
C1 [Consoer, Daniel M.; Hoffman, Alex D.; Fitzsimmons, Patrick N.; Kosian, Patricia A.; Nichols, John W.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Nichols, JW (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM nichols.john@epa.gov
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does the mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 67
TC 5
Z9 6
U1 3
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
EI 1879-1514
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD NOV
PY 2014
VL 156
BP 65
EP 73
DI 10.1016/j.aquatox.2014.07.022
PG 9
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA AT8NO
UT WOS:000345190000008
PM 25150511
ER
PT J
AU Maloney, SK
Fuller, A
Mitchell, D
Gordon, C
Overton, JM
AF Maloney, Shane K.
Fuller, Andrea
Mitchell, Duncan
Gordon, Christopher
Overton, J. Michael
TI Translating Animal Model Research: Does It Matter That Our Rodents Are
Cold?
SO PHYSIOLOGY
LA English
DT Article
ID DIET-INDUCED THERMOGENESIS; BROWN ADIPOSE-TISSUE; AMBIENT-TEMPERATURE;
LABORATORY MICE; NONSHIVERING THERMOGENESIS; HOUSING TEMPERATURE;
CALORIC RESTRICTION; BODY-TEMPERATURE; TRANSGENIC MICE; OLD RATS
AB Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality.
C1 [Maloney, Shane K.; Mitchell, Duncan] Univ Western Australia, Sch Anat Physiol & Human Biol, Crawley, WA, Australia.
[Maloney, Shane K.; Fuller, Andrea; Mitchell, Duncan] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Brain Funct Res Grp, Parktown, South Africa.
[Gordon, Christopher] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
[Overton, J. Michael] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA.
RP Maloney, SK (reprint author), Univ Western Australia, Sch Anat Physiol & Human Biol, Stirling Highway, Crawley, WA, Australia.
OI Fuller, Andrea/0000-0001-6370-8151
NR 66
TC 19
Z9 20
U1 6
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1548-9213
EI 1548-9221
J9 PHYSIOLOGY
JI Physiology
PD NOV 1
PY 2014
VL 29
IS 6
BP 413
EP 420
DI 10.1152/physiol.00029.2014
PG 8
WC Physiology
SC Physiology
GA AT5QB
UT WOS:000344996000006
PM 25362635
ER
PT J
AU Burns, CJ
Wright, M
Pierson, JB
Bateson, TF
Burstyn, I
Goldstein, DA
Klaunig, JE
Luben, TJ
Mihlan, G
Ritter, L
Schnatter, AR
Symons, JM
Yi, KD
AF Burns, Carol J.
Wright, Michael
Pierson, Jennifer B.
Bateson, Thomas F.
Burstyn, Igor
Goldstein, Daniel A.
Klaunig, James E.
Luben, Thomas J.
Mihlan, Gary
Ritter, Leonard
Schnatter, A. Robert
Symons, J. Morel
Yi, Kun Don
TI Evaluating Uncertainty to Strengthen Epidemiologic Data for Use in Human
Health Risk Assessments
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID MATCHED CASE-CONTROL; MEASUREMENT ERROR; SENSITIVITY-ANALYSIS; EXPOSURE
ASSESSMENT; OCCUPATIONAL ASTHMA; BAYESIAN-ANALYSIS; LUNG-CANCER;
MISCLASSIFICATION; FRAMEWORK; BIAS
AB Background: There is a recognized ned to improve the application of epidemiologic data in human health risk assessment especially for understanding and characterizing risks from environmental and occupational exposures. Although there is uncertainty associated with the results of most epidemiologic studies, techniques exist to characterize uncertainty that can be applied to improve weight-of-evidence evaluations and risk characterization efforts.
Methods: This report derives from a Health and Environmental Sciences Institute (HESI) workshop held in Research Triangle Park, North Carolina, to discuss the utility of using epidemiologic data in risk assessments, including the use of advanced analytic methods to address sources of uncertainty. Epidemiologists, toxicologists, and risk assessors from academia, government, and industry convened to discuss uncertainty, exposure assessment, and application of analytic methods to address these challenges.
Synthesis: Several recommendations emerged to help improve the utility of epidemiologic data in risk assessment. For example, improved characterization of uncertainty is needed to allow risk assessors to quantitatively assess potential sources of bias. Data are needed to facilitate this quantitative analysis, and inter-disciplinary approaches will help ensure that sufficient information is collected for a thorough uncertainty evaluation. Advanced analytic methods and tools such as directed acyclic graphs (DAGs) and Bayesian statistical techniques can provide important insights and support interpretation of epidemiologic data.
Conclusions: The discussions and recommendations from this workshop demonstrate that there are practical steps that the scientific community can adopt to strengthen epidemiologic data for decision making.
C1 [Burns, Carol J.] Dow Chem Co USA, Midland, MI 48674 USA.
[Wright, Michael] US EPA, NCEA, Cincinnati, OH USA.
[Pierson, Jennifer B.] ILSI, HESI, Washington, DC USA.
[Bateson, Thomas F.] US EPA, NCEA, Washington, DC 20460 USA.
[Burstyn, Igor] Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA 19104 USA.
[Goldstein, Daniel A.] Monsanto Co, St Louis, MO USA.
[Klaunig, James E.] Indiana Univ, Sch Publ Hlth, Dept Environm Hlth, Bloomington, IN USA.
[Luben, Thomas J.] US EPA, NCEA, Res Triangle Pk, NC USA.
[Mihlan, Gary] Bayer CropSci, Res Triangle Pk, NC USA.
[Ritter, Leonard] Univ Guelph, Sch Environm Sci, Guelph, ON N1G 2W1, Canada.
[Schnatter, A. Robert] ExxonMobil Biomedical Sci Inc, Annandale, NJ USA.
[Symons, J. Morel] EI Pont Nemours & Co, Newark, DC USA.
[Yi, Kun Don] Syngenta Crop Protect LLC, Greensboro, NC USA.
RP Pierson, JB (reprint author), 1156 15th St NW,2nd Floor, Washington, DC 20005 USA.
EM jpierson@hesiglobal.org
FU ILSI-HESI
FX This work was conducted under the auspices of the ILSI-HESI Subcommittee
on Evaluating Causality in Epidemiologic Studies. HESI is a public,
nonprofit foundation whose mission is to engage scientists from
academia, government, and industry to identify and resolve global health
and environmental issues. HESI receives support primarily from its
industry sponsors. Participating organizations from the HESI
Epidemiology Subcommittee included Bayer CropScience, DLW Consulting
Services LLC, The Dow Chemical Company, Drexel University, E. I. du Pont
de Nemours and Company, ExxonMobil Biomedical Sciences Inc., Harvard
School of Public Health, Indiana University, Monsanto, Procter & Gamble
Co., Shell Oil Company, Syngenta Crop Protection LLC, University of
Aarhus, University of Guelph, University of Leicester, NCEA/U.S. EPA,
and Wake Forest University.
NR 64
TC 4
Z9 5
U1 1
U2 11
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2014
VL 122
IS 11
BP 1160
EP 1165
DI 10.1289/ehp.1308062
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AT2IZ
UT WOS:000344759500016
PM 25079138
ER
PT J
AU Vinikoor-Imler, LC
Owens, EO
Nichols, JL
Ross, M
Brown, JS
Sacks, JD
AF Vinikoor-Imler, Lisa C.
Owens, Elizabeth O.
Nichols, Jennifer L.
Ross, Mary
Brown, James S.
Sacks, Jason D.
TI Evaluating Potential Response-Modifying Factors for Associations between
Ozone and Health Outcomes: A Weight-of-Evidence Approach
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID CASE-CROSSOVER ANALYSIS; INDUCED AIRWAY HYPERRESPONSIVENESS; INDUCED
PULMONARY INFLAMMATION; EMERGENCY-DEPARTMENT VISITS; INDUCED LUNG
INFLAMMATION; NITRIC-OXIDE SYNTHASE; TOLL-LIKE RECEPTOR-4; ASTHMATIC
SUBJECTS; MEXICO-CITY; ANTIOXIDANT SUPPLEMENTATION
AB Background: Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O-3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O-3-related health effects.
Objectives: We sought to identify potential response-modifying factors to determine whether specific groups of the population or life stages are at increased or decreased risk of O-3-related health effects using a weight-of-evidence approach.
Methods: Epidemiologic, experimental, and exposure science studies of potential factors that may modify the relationship between O3 and health effects were identified in U. S. Environmental Protection Agency's 2013 Integrated Science Assessment for Ozone and Related Photochemical Oxidants. Scientific evidence from studies that examined factors that may influence risk were integrated across disciplines to evaluate consistency, coherence, and biological plausibility of effects. The factors identified were then classified using a weight-of-evidence approach to conclude whether a specific factor modified the response of a population or life stage, resulting in an increased or decreased risk of O-3-related health effects.
Discussion: We found "adequate" evidence that populations with certain genotypes, preexisting asthma, or reduced intake of certain nutrients, as well as different life stages or outdoor workers, are at increased risk of O-3-related health effects. In addition, we identified other factors (i.e., sex, socioeconomic status, and obesity) for which there was "suggestive" evidence that they may increase the risk of O-3-related health effects.
Conclusions: Using a weight-of-evidence approach, we identified a diverse group of factors that should be considered when characterizing the overall risk of health effects associated with exposures to ambient O-3.
C1 [Vinikoor-Imler, Lisa C.; Owens, Elizabeth O.; Ross, Mary; Brown, James S.; Sacks, Jason D.] US EPA, NCEA, Res Triangle Pk, NC 27711 USA.
[Nichols, Jennifer L.] US EPA, NCEA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Vinikoor-Imler, LC (reprint author), 109 TW Alexander Dr,MD B243-01, Res Triangle Pk, NC 27711 USA.
EM vinikoor-imler.lisa@epa.gov
FU National Center of Environmental Assessment, Office of Research and
Development, U.S. EPA
FX This project was supported in part by the appointment of J.L.N. to the
Research Participation Program at the National Center of Environmental
Assessment, Office of Research and Development, U.S. EPA, administered
by the Oak Ridge Institute for Science and Education through an
interagency agreement between the U.S. Department of Energy
NR 141
TC 8
Z9 8
U1 2
U2 22
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2014
VL 122
IS 11
BP 1166
EP 1176
DI 10.1289/ehp.1307541
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AT2IZ
UT WOS:000344759500017
PM 24927060
ER
PT J
AU Dionisio, KL
Baxter, LK
Chang, HH
AF Dionisio, Kathie L.
Baxter, Lisa K.
Chang, Howard H.
TI An Empirical Assessment of Exposure Measurement Error and Effect
Attenuation in Bipollutant Epidemiologic Models
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID EMERGENCY-DEPARTMENT VISITS; AMBIENT AIR-POLLUTION; TIME-SERIES;
PARTICULATE MATTER; NITROGEN-DIOXIDE; ATLANTA; HEALTH; POLLUTANTS;
OZONE; QUALITY
AB BACKGROUND: Using multipollutant models to understand combined health effects of exposure to multiple pollutants is becoming more common. However, complex relationships between pollutants and differing degrees of exposure error across pollutants can make health effect estimates from multipollutant models difficult to interpret.
OBJECTIVES: We aimed to quantify relationships between multiple pollutants and their associated exposure errors across metrics of exposure and to use empirical values to evaluate potential attenuation of coefficients in epidemiologic models.
METHODS: We used three daily exposure metrics (central-site measurements, air quality model estimates, and population exposure model estimates) for 193 ZIP codes in the Atlanta, Georgia, metropolitan area from 1999 through 2002 for PM2.5 and its components (EC and SO4), as well as O-3, CO, and NOx, to construct three types of exposure error: delta(spatial) (comparing air quality model estimates to central-site measurements), delta(population) (comparing population exposure model estimates to air quality model estimates), and delta(total) (comparing population exposure model estimates to central-site measurements). We compared exposure metrics and exposure errors within and across pollutants and derived attenuation factors (ratio of observed to true coefficient for pollutant of interest) for single- and bipollutant model coefficients.
RESULTS: Pollutant concentrations and their exposure errors were moderately to highly correlated (typically, > 0.5), especially for CO, NOx, and EC (i.e., "local" pollutants); correlations differed across exposure metrics and types of exposure error. Spatial variability was evident, with variance of exposure error for local pollutants ranging from 0.25 to 0.83 for delta(spatial) and delta(total). The attenuation of model coefficients in single-and bipollutant epidemiologic models relative to the true value differed across types of exposure error, pollutants, and space.
CONCLUSIONS: Under a classical exposure-error framework, attenuation may be substantial for local pollutants as a result of delta(spatial) and delta(total) with true coefficients reduced by a factor typically < 0.6 (results varied for delta(population) and regional pollutants).
C1 [Dionisio, Kathie L.; Baxter, Lisa K.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA.
[Chang, Howard H.] Emory Univ, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA.
RP Dionisio, KL (reprint author), US EPA, 109 TW Alexander Dr,Mail Code E205-02, Res Triangle Pk, NC 27709 USA.
EM dionisio.kathie@epa.gov
FU U.S. EPA, through its Office of Research and Development, National
Exposure Research Laboratory [CR-83407301-1]; U.S. EPA Clean Air
Research Center grant; Georgia Institute of Technology [R834799];
National Institutes of Health [1R21ES022795-01A1]
FX The U.S. EPA, through its Office of Research and Development, National
Exposure Research Laboratory, funded and collaborated in the research
described here under cooperative agreement CR-83407301-1 to Emory
University, and by a U.S. EPA Clean Air Research Center grant to Emory
University and the Georgia Institute of Technology (R834799). This work
was also funded by grant 1R21ES022795-01A1 from the National Institutes
of Health.
NR 31
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Z9 6
U1 0
U2 15
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2014
VL 122
IS 11
BP 1216
EP 1224
DI 10.1289/ehp.1307772
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AT2IZ
UT WOS:000344759500023
PM 25003573
ER
PT J
AU Divi, RL
Lindeman, TLE
Shockley, ME
Keshava, C
Weston, A
Poirier, MC
AF Divi, Rao L.
Lindeman, Tracey L. Einem
Shockley, Marie E.
Keshava, Channa
Weston, Ainsley
Poirier, Miriam C.
TI Correlation between CYP1A1 transcript, protein level, enzyme activity
and DNA adduct formation in normal human mammary epithelial cell strains
exposed to benzo[a]pyrene
SO MUTAGENESIS
LA English
DT Article
ID FED COAL-TAR; BREAST-CANCER; DIOL-EPOXIDE; P450 REDUCTASE;
DT-DIAPHORASE; EROD ACTIVITY; RISK; MICE; CYTOCHROME-P450; BIOMARKERS
AB The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and CYP1B1, and other enzymes, to form r7, t8, t9-trihydroxy-c-10-(N (2) -deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]-pyrene (BPdG). Evaluation of RNA expression data, to understand the contribution of different metabolic enzymes to BPdG formation, is typically presented as fold-change observed upon BP exposure, leaving the actual number of RNA transcripts unknown. Here, we have quantified RNA copies/ng cDNA (RNA cpn) for CYP1A1 and CYP1B1, as well as NAD(P)H:quinone oxidoreductase 1 (NQO1), which may reduce formation of BPdG adducts, using primary normal human mammary epithelial cell (NHMEC) strains, and the MCF-7 breast cancer cell line. In unexposed NHMECs, basal RNA cpn values were 58-836 for CYP1A1, 336-5587 for CYP1B1 and 5943-40112 for NQO1. In cells exposed to 4.0 A mu M BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1. There were 3.5 (mean, range 0.2-15.8) BPdG adducts/10(8) nucleotides in the NHMECs (n = 16), and 790 in the MCF-7s. In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not. Western blots of four NHMEC strains, chosen for different levels of BPdG adducts, showed a linear correlation between BPdG and CYP1A1, but not CYP1B1 or NQO1. Ethoxyresorufin-O-deethylase (EROD) activity, which measures CYP1A1 and CYP1B1 together, correlated with BPdG, but NQO1 activity did not. Despite more numerous levels of CYP1B1 and NQO1 RNA cpn in unexposed and BP-exposed NHMECs and MCF-7cells, BPdG formation was only correlated with induction of CYP1A1 RNA cpn. The higher level of BPdG in MCF-7 cells, compared to NHMECs, may have been due to a much increased induction of CYP1A1 and EROD. Overall, BPdG correlation was observed with CYP1A1 protein and CYP1A1/1B1 enzyme activity, but not with CYP1B1 or NQO1 protein, or NQO1 enzyme activity.
C1 [Divi, Rao L.; Lindeman, Tracey L. Einem; Shockley, Marie E.; Poirier, Miriam C.] NCI, Carcinogen DNA Interact Sect, Ctr Canc Res, NIH, Bethesda, MD 20817 USA.
[Keshava, Channa] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Weston, Ainsley] Ctr Dis Control & Prevent, Div Resp Dis Studies, NIOSH, Morgantown, WV 26505 USA.
RP Poirier, MC (reprint author), NCI, Carcinogen DNA Interact Sect, Ctr Canc Res, NIH, Bethesda, MD 20817 USA.
EM poirierm@exchange.nih.gov
FU Intramural NIH HHS
NR 39
TC 4
Z9 4
U1 3
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD NOV
PY 2014
VL 29
IS 6
BP 409
EP 417
DI 10.1093/mutage/geu049
PG 9
WC Genetics & Heredity; Toxicology
SC Genetics & Heredity; Toxicology
GA AT0KI
UT WOS:000344624700003
PM 25245543
ER
PT J
AU Thybaud, V
Van Benthem, J
Delrue, N
Douglas, GR
Lorge, E
Lovell, DP
Moore, MM
Schoeny, R
Singer, T
AF Thybaud, Veronique
Van Benthem, Jan
Delrue, Nathalie
Douglas, George R.
Lorge, Elisabeth
Lovell, David P.
Moore, Martha M.
Schoeny, Rita
Singer, Tim
TI Revision of OECD guidelines for genotoxicity: current status and next
steps
SO MUTAGENESIS
LA English
DT Meeting Abstract
C1 [Thybaud, Veronique] Sanofi, Vitry Sur Seine, France.
[Van Benthem, Jan] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
[Delrue, Nathalie] OECD, Paris, France.
[Douglas, George R.; Singer, Tim] Hlth Canada, Ottawa, ON K1A 0L2, Canada.
[Lorge, Elisabeth] Servier Grp, Orleans, France.
[Lovell, David P.] Univ London, London WC1E 7HU, England.
[Moore, Martha M.] ENVIRON Int Corp, Little Rock, AR USA.
[Schoeny, Rita] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD NOV
PY 2014
VL 29
IS 6
BP 517
EP 517
PG 1
WC Genetics & Heredity; Toxicology
SC Genetics & Heredity; Toxicology
GA AT0KI
UT WOS:000344624700075
ER
PT J
AU Smucker, NJ
Detenbeck, NE
AF Smucker, Nathan J.
Detenbeck, Naomi E.
TI Meta-Analysis of Lost Ecosystem Attributes in Urban Streams and the
Effectiveness of Out-of-Channel Management Practices
SO RESTORATION ECOLOGY
LA English
DT Article
DE algae; biodiversity; ecosystem function; fish; macroinvertebrates;
restoration; stormwater; watershed condition
ID RIVER RESTORATION SUCCESS; LAND-USE; MACROINVERTEBRATE COMMUNITIES;
URBANIZATION; LANDSCAPE; RESPONSES; CATCHMENT; FISH; BIODIVERSITY;
AUSTRALIA
AB Urban development is a leading cause of stream impairment that reduces biodiversity and negatively affects ecosystem processes and habitat. Out-of-stream restoration practices, such as stormwater ponds, created wetlands, and restored riparian vegetation, are increasingly implemented as management strategies to mitigate impacts. However, uncertainty exists regarding how effectively they improve downstream ecosystems because monitoring is uncommon and results are typically reported on a case-by-case basis. We conducted a meta-analysis of literature and used response ratios to quantify how downstream ecosystems change in response to watershed development and to out-of-stream restoration. Biodiversity in unrestored urban streams was 47% less than that in reference streams, and ecological communities, habitat, and rates of nutrient cycling were negatively affected as well. Mean measures of ecosystem attributes in restored streams were significantly greater than, and 156% of, those in unrestored urban streams. Measures of biodiversity in restored streams were 132% of those in unrestored urban streams, and indices of biotic condition, community structure, and nutrient cycling significantly improved. However, ecosystem attributes and biodiversity at restored sites were significantly less than, and only 60% and 45% of, those in reference streams, respectively. Out-of-stream management practices improved ecological conditions in urban streams but still failed to restore reference stream conditions. Despite statistically significant improvements, assessing restoration success remains difficult due to few comparisons to reference sites or to clearly defined targets. These findings can inform future monitoring, management, and development strategies and highlight the need for preventative actions in a watershed context.
C1 [Smucker, Nathan J.; Detenbeck, Naomi E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Smucker, NJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM smucker.nathan@epa.gov
NR 51
TC 16
Z9 16
U1 4
U2 93
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1061-2971
EI 1526-100X
J9 RESTOR ECOL
JI Restor. Ecol.
PD NOV
PY 2014
VL 22
IS 6
BP 741
EP 748
DI 10.1111/rec.12134
PG 8
WC Ecology
SC Environmental Sciences & Ecology
GA AS8DL
UT WOS:000344480300006
ER
PT J
AU Ranson, M
Kousky, C
Ruth, M
Jantarasami, L
Crimmins, A
Tarquinio, L
AF Ranson, Matthew
Kousky, Carolyn
Ruth, Matthias
Jantarasami, Lesley
Crimmins, Allison
Tarquinio, Lisa
TI Tropical and extratropical cyclone damages under climate change
SO CLIMATIC CHANGE
LA English
DT Article
ID FUTURE CLIMATE; STORM LOSSES; SIMULATIONS; IMPACTS; COSTS; FUND; GCM; US
AB This paper provides the first quantitative synthesis of the rapidly growing literature on future tropical and extratropical cyclone damages under climate change. We estimate a probability distribution for the predicted impact of changes in global surface air temperatures on future storm damages, using an ensemble of 478 estimates of the temperature-damage relationship from nineteen studies. Our analysis produces three main empirical results. First, we find strong but not conclusive support for the hypothesis that climate change will cause damages from tropical cyclones and wind storms to increase, with most models predicting higher future storm damages due to climate change. Second, there is substantial variation in projected changes in losses across regions. Potential changes in damages are greatest in the North Atlantic basin, where the multi-model average predicts that a 2.5 A degrees C increase in global surface air temperature would cause hurricane damages to increase by 63 %. The ensemble predictions for Western North Pacific tropical cyclones and European wind storms (extratropical cyclones) are +28 % and +23 %, respectively. Finally, our analysis shows that existing models of storm damages under climate change generate a wide range of predictions, ranging from moderate decreases to very large increases in losses.
C1 [Ranson, Matthew; Tarquinio, Lisa] ABT Associates Inc, Cambridge, MA 02138 USA.
[Kousky, Carolyn] Resources Future Inc, Washington, DC 20036 USA.
[Ruth, Matthias] Northeastern Univ, Boston, MA 02115 USA.
[Jantarasami, Lesley; Crimmins, Allison] US EPA, Climate Change Div, Washington, DC 20460 USA.
RP Ranson, M (reprint author), ABT Associates Inc, 55 Wheeler St, Cambridge, MA 02138 USA.
EM matthew_ranson@abtassoc.com
FU U.S. Environmental Protection Agency's Climate Change Division
[EP-BPA-12-H-0024]
FX The authors wish to acknowledge the financial support of the U.S.
Environmental Protection Agency's Climate Change Division (Contract
EP-BPA-12-H-0024). The views expressed in this document are solely those
of the authors, and do not necessarily reflect those of U.S. EPA or Abt
Associates. The authors thank Eberhard Faust, James Palardy, Marcus
Sarofim, and seminar participants at Abt Associates for helpful
suggestions. Any errors are our own responsibility.
NR 35
TC 3
Z9 3
U1 1
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-0009
EI 1573-1480
J9 CLIMATIC CHANGE
JI Clim. Change
PD NOV
PY 2014
VL 127
IS 2
BP 227
EP 241
DI 10.1007/s10584-014-1255-4
PG 15
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AS6QG
UT WOS:000344387000006
ER
PT J
AU Ankley, GT
Jensen, KM
AF Ankley, Gerald T.
Jensen, Kathleen M.
TI A NOVEL FRAMEWORK FOR INTERPRETATION OF DATA FROM THE FISH SHORT-TERM
REPRODUCTION ASSAY (FSTRA) FOR THE DETECTION OF ENDOCRINE-DISRUPTING
CHEMICALS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Endocrine-disrupting chemicals; Fish; Reproduction; Screening;
Regulation
ID MINNOW PIMEPHALES-PROMELAS; FATHEAD MINNOW; ANDROGEN
17-ALPHA-METHYLTESTOSTERONE; ANTIANDROGEN FLUTAMIDE; SYNTHETIC
PROGESTINS; MECHANISTIC BASIS; RECEPTOR AGONIST; LIFE-CYCLE; INHIBITOR;
VITELLOGENIN
AB The fish short-term reproduction assay (FSTRA) is a key component of the US Environmental Protection Agency's Endocrine Disruptor Screening Program (EDSP), which uses a weight-of-evidence analysis based on data from several assays to identify the potential for chemicals to act as agonists or antagonists of the estrogen or androgen receptors (ER and AR), or inhibitors of steroidogenic enzymes. The FSTRA considers a variety of mechanistic and apical responses in 21-d exposures with the fathead minnow (Pimephales promelas), including plasma steroid and vitellogenin (VTG; egg yolk protein) concentrations, secondary sex characteristics, gonad size and histopathology, and egg production. Although the FSTRA initially was described several years ago, recent data generation associated with implementation of the EDSP highlighted the need for more formal guidance regarding evaluation of information from the assay. The authors describe a framework for interpretation of FSTRA data relative to perturbation of endocrine pathways of concern to the EDSP. The framework considers end points individually and as suites of physiologically related responses relative to pathway identification. Sometimes changes in single end points can be highly diagnostic (e.g., induction of VTG in males by ER agonists, production of male secondary sex characteristics in females by AR agonists); in other instances, however, multiple, related end points are needed to reliably assess pathway perturbation (e.g., AR antagonism, steroid synthesis inhibition). In addition to describing an interpretive framework, the authors demonstrate its practical utility using publicly available FSTRA data for a wide range of known and hypothesized endocrine-disrupting chemicals. Environ Toxicol Chem 2014;33:2529-2540. Published 2014 Wiley Periodicals Inc., on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
C1 [Ankley, Gerald T.; Jensen, Kathleen M.] US EPA, Midcontinent Ecol Div, Off Res & Dev, Duluth, MN 55804 USA.
RP Ankley, GT (reprint author), US EPA, Midcontinent Ecol Div, Off Res & Dev, Duluth, MN 55804 USA.
EM ankley.gerald@epa.gov
NR 72
TC 10
Z9 10
U1 4
U2 37
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD NOV
PY 2014
VL 33
IS 11
BP 2529
EP 2540
DI 10.1002/etc.2708
PG 12
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AS3LB
UT WOS:000344178100021
PM 25098918
ER
PT J
AU Sutula, M
Green, L
Cicchetti, G
Detenbeck, N
Fong, P
AF Sutula, Martha
Green, Lauri
Cicchetti, Giancarlo
Detenbeck, Naomi
Fong, Peggy
TI Thresholds of Adverse Effects of Macroalgal Abundance and Sediment
Organic Matter on Benthic Habitat Quality in Estuarine Intertidal Flats
SO ESTUARIES AND COASTS
LA English
DT Article
DE Macroalgae; Eutrophication; Thresholds; Sediment profile imaging;
Benthic habitat quality; Percent organic carbon; Percent nitrogen
ID LONG-TERM CHANGES; ENTEROMORPHA-INTESTINALIS; NUTRIENT ENRICHMENT;
PROFILE CAMERA; TROPHIC STATUS; IN-SITU; MATS; GROWTH; BAY; CONSEQUENCES
AB Confidence in the use of macroalgae as an indicator of estuarine eutrophication is limited by the lack of quantitative data on the thresholds of its adverse effects on benthic habitat quality. In the present study, we utilized sediment profile imagery (SPI) to identify thresholds of adverse effects of macroalgal biomass, sediment organic carbon (% OC) and sediment nitrogen (% N) concentrations on the apparent Redox Potential Discontinuity (aRPD), the depth that marks the boundary between oxic near-surface sediment and the underlying suboxic or anoxic sediment. At 16 sites in eight California estuaries, SPI, macroalgal biomass, sediment percent fines, % OC, and % N were analyzed at 20 locations along an intertidal transect. Classification and Regression Tree (CART) analysis was used to identify step thresholds associated with a transition from "reference" or natural background levels of macroalgae, defined as that range in which no effect on aRPD was detected. Ranges of 3-15 g dw macroalgae m(-2), 0.4-0.7 % OC and 0.05-0.07 % N were identified as transition zones from reference conditions across these estuaries. Piecewise regression analysis was used to identify exhaustion thresholds, defined as a region along the stress-response curve where severe adverse effects occur; levels of 175 g dw macroalgae m(-2), 1.1 % OC and 0.1 % N were identified as thresholds associated with a shallowing of aRPD to near zero depths. As an indicator of ecosystem condition, shallow aRPD has been related to reduced volume and quality for benthic infauna and alteration in community structure. These effects have been linked to reduced availability of forage for fish, birds and other invertebrates, as well as to undesirable changes in biogeochemical cycling.
C1 [Sutula, Martha] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA.
[Green, Lauri; Fong, Peggy] Univ Calif Los Angeles, Dept Evolutionary Biol & Ecol, Los Angeles, CA 90095 USA.
[Cicchetti, Giancarlo; Detenbeck, Naomi] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Sutula, M (reprint author), Southern Calif Coastal Water Res Project, 3535 Harbor Blvd, Costa Mesa, CA 92626 USA.
EM marthas@sccwrp.org
RI Fong, Patrick S.W./O-7315-2014
OI Fong, Patrick S.W./0000-0002-2017-5698
FU California State Water Resources Control Board [07-110-250-1]
FX Funding for this study was provided through a contract with the
California State Water Resources Control Board (07-110-250-1). This
study would not have been possible without the hard work and dedication
of students and staff from UCLA and SCCWRP, in particular, Courtney
Neumann, who performed all of the digital imaging analysis of the SPI
photographs, and Caitlin Fong, Sarah Bittick and Greg Lyon, who led
field work. The authors also wish to express their gratitude to Becky
Schaffner for assistance with map preparation.
NR 62
TC 7
Z9 7
U1 2
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD NOV
PY 2014
VL 37
IS 6
BP 1532
EP 1548
DI 10.1007/s12237-014-9796-3
PG 17
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AR6WY
UT WOS:000343722700016
ER
PT J
AU Moya, J
Phillips, L
AF Moya, Jacqueline
Phillips, Linda
TI A review of soil and dust ingestion studies for children
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Review
ID MOUTH FREQUENCY DATA; SUPERFUND SITE; YOUNG-CHILDREN; TRACER ELEMENTS;
PREGNANT-WOMEN; MASS-BALANCE; LEAD; PICA; EXPOSURE; METAANALYSIS
AB Soil and dust ingestion by children may be important pathways of exposure to environmental contaminants. Contaminated soil and dust may end up on children's hands and objects, because they play close to the ground. These contaminants can be ingested by children, because they have a tendency to place objects, including their fingers, in their mouths. Assessing exposure through this pathway requires information about the amount of soil and dust ingested by children. Estimates of soil and dust ingestion and information on the prevalence of the behavior have been published in the literature, but research in this area is generally limited. Three methodologies have been used to quantify soil and dust ingestion rates. In this paper, these are referred to as the tracer element method, the biokinetic model comparison method, and the activity pattern method. This paper discusses the information available on the prevalence of soil and dust ingestion behavior, summarizes the three methodologies for quantifying soil and dust ingestion, and discusses their limitations. Soil ingestion data derived from studies that use these methodologies are also summarized. Although they are based on different estimation approaches, the central tendency estimates of soil and dust ingestion derived from the three methodologies are generally comparable.
C1 [Moya, Jacqueline; Phillips, Linda] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Phillips, L (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Mailcode 8623P,1200 Penn Ave NW, Washington, DC 20460 USA.
EM phillips.linda@epa.gov
NR 64
TC 6
Z9 6
U1 2
U2 24
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD NOV-DEC
PY 2014
VL 24
IS 6
BP 545
EP 554
DI 10.1038/jes.2014.17
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AS0IJ
UT WOS:000343960800001
PM 24691008
ER
PT J
AU Breen, MS
Schultz, BD
Sohn, MD
Long, T
Langstaff, J
Williams, R
Isaacs, K
Meng, QY
Stallings, C
Smith, L
AF Breen, Michael S.
Schultz, Bradley D.
Sohn, Michael D.
Long, Thomas
Langstaff, John
Williams, Ronald
Isaacs, Kristin
Meng, Qing Yu
Stallings, Casson
Smith, Luther
TI A review of air exchange rate models for air pollution exposure
assessments
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Review
DE Air exchange rate models; air pollution; exposure assessment; leakage;
natural ventilation; mechanical ventilation
ID PARTICULATE MATTER; UNITED-STATES; INFILTRATION; OUTDOOR; WIND;
TEMPERATURE; BUILDINGS; INDOOR; VENTILATION; POLLUTANTS
AB A critical aspect of air pollution exposure assessments is estimation of the air exchange rate (AER) for various buildings where people spend their time. The AER, which is the rate of exchange of indoor air with outdoor air, is an important determinant for entry of outdoor air pollutants and for removal of indoor-emitted air pollutants. This paper presents an overview and critical analysis of the scientific literature on empirical and physically based AER models for residential and commercial buildings; the models highlighted here are feasible for exposure assessments as extensive inputs are not required. Models are included for the three types of airflows that can occur across building envelopes: leakage, natural ventilation, and mechanical ventilation. Guidance is provided to select the preferable AER model based on available data, desired temporal resolution, types of airflows, and types of buildings included in the exposure assessment. For exposure assessments with some limited building leakage or AER measurements, strategies are described to reduce AER model uncertainty. This review will facilitate the selection of AER models in support of air pollution exposure assessments.
C1 [Breen, Michael S.; Schultz, Bradley D.; Williams, Ronald; Isaacs, Kristin] US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Sohn, Michael D.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Dept Energy Anal & Environm Impacts, Berkeley, CA 94720 USA.
[Long, Thomas] US EPA, Natl Ctr Environm Assessments, Res Triangle Pk, NC 27711 USA.
[Langstaff, John] US EPA, Off Air Qual & Planning Stand, Res Triangle Pk, NC 27711 USA.
[Meng, Qing Yu] UMDNJ Sch Publ Hlth, Dept Environm & Occupat Hlth, Piscataway, NJ USA.
[Stallings, Casson; Smith, Luther] Alion Sci & Technol Inc, Res Triangle Pk, NC USA.
RP Breen, MS (reprint author), US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Exposure Modeling Res Branch,Off Res & Dev, 109 TW Alexander Dr,Mail E205-02, Res Triangle Pk, NC 27711 USA.
EM breen.michael@epa.gov
FU U.S. Department of Energy [DE-AC02-05CH11231]
FX We thank Jennifer Richmond-Bryant and Vito Ilacqua for review comments
and helpful suggestions. Although the manuscript was reviewed by the US
Environmental Protection Agency and approved for publication, it may not
necessarily reflect official Agency policy. Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use. Michael Sohn performed this work under Contract No.
DE-AC02-05CH11231 with the U.S. Department of Energy.
NR 61
TC 9
Z9 9
U1 3
U2 33
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD NOV-DEC
PY 2014
VL 24
IS 6
BP 555
EP 563
DI 10.1038/jes.2013.30
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AS0IJ
UT WOS:000343960800002
PM 23715084
ER
PT J
AU Xue, J
Liu, SV
Zartarian, VG
Geller, AM
Schultz, BD
AF Xue, Jianping
Liu, Shi V.
Zartarian, Valerie G.
Geller, Andrew M.
Schultz, Bradley D.
TI Analysis of NHANES measured blood PCBs in the general US population and
application of SHEDS model to identify key exposure factors
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE PCBs; NHANES; SHEDS; dietary exposure; exposure modeling; biomonitoring
ID POLYCHLORINATED BIPHENYL LEVELS; PERSISTENT ORGANIC POLLUTANTS;
GREAT-LAKES; SERUM CONCENTRATIONS; NONDIABETIC ADULTS; FISH CONSUMPTION;
TEMPORAL TRENDS; CHILDREN; DISEASE; MICHIGAN
AB Studies have shown that the US population continues to be exposed to polychlorinated biphenyls (PCBs), despite their ban more than three decades ago, but the reasons are not fully understood. The objectives of this paper are to characterize patterns of PCBs in blood by age, gender, and ethnicity, and identify major exposure factors. EPA's Stochastic Human Exposure and Dose Simulation (SHEDS)-dietary exposure model was applied, combining fish tissue PCB levels from a NYC Asian Market survey with National Health and Nutrition Examination Survey (NHANES) dietary consumption data, and then linked with blood biomarkers for the same NHANES study subjects. Results reveal that the mean concentration of total PCBs in blood was higher with increasing age; however, for the same age, gender, and ethnicity, the blood PCB concentrations measured in the later NHANES survey were significantly lower than those in the earlier one. The decrease within an age group between the two survey periods lessened with increasing age. Blood PCBs among different ethnicities ranked differently between the older and the younger age groups within each survey. Non-Hispanic Blacks had significantly higher blood PCBs for the >30 year age group. For the 12 to <= 30 year age group, the "Asian, Pacific Islander, Native American or multiracial" group had the highest values, with patterns fairly consistent with fish consumption and modeled PCB exposure patterns. We conclude that for younger people, patterns correspond to reduced environmental contamination over time, and are strongly associated with fish consumption and dietary exposures. Higher PCB concentrations in blood of the older population may partially reflect past exposures to higher environmental PCB concentrations, particularly before the ban.
C1 [Xue, Jianping; Liu, Shi V.; Zartarian, Valerie G.; Geller, Andrew M.; Schultz, Bradley D.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Xue, J (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, NC, 109 TW Alexander Dr,MD E205-02, Res Triangle Pk, NC 27711 USA.
EM Xue.jianping@epa.gov; Liu.Shi@epa.gov
NR 48
TC 7
Z9 7
U1 0
U2 20
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD NOV-DEC
PY 2014
VL 24
IS 6
BP 615
EP 621
DI 10.1038/jes.2013.91
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA AS0IJ
UT WOS:000343960800010
PM 24424407
ER
PT J
AU Varughese, EA
Bennett-Stamper, CL
Wymer, LJ
Yadav, JS
AF Varughese, Eunice A.
Bennett-Stamper, Christina L.
Wymer, Larry J.
Yadav,