FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Liu, J Matulonis, UA AF Liu, Joyce Matulonis, Ursula A. TI New Strategies in Ovarian Cancer: Translating the Molecular Complexity of Ovarian Cancer into Treatment Advances SO CLINICAL CANCER RESEARCH LA English DT Article ID OLAPARIB MAINTENANCE THERAPY; NEGATIVE BREAST-CANCER; FOCAL ADHESION KINASE; PHASE-III TRIAL; OPEN-LABEL; EPITHELIAL OVARIAN; FALLOPIAN-TUBE; PRIMARY PERITONEAL; PARP INHIBITION; DOUBLE-BLIND AB An improved understanding of the genomics of ovarian cancer and the separation of ovarian cancer into histologically and molecularly defined subgroups have affected drug development and clinical trial design in ovarian cancer. Active therapies that have been tested in ovarian cancer include agents that inhibit angiogenesis and poly (ADP-ribose) polymerase inhibitors (PARPi). However, no FDA drug approvals for ovarian cancer have been granted since 2006, and overall survival improvements have been difficult to achieve with new agents. The genomic complexity of ovarian cancer and modest single-agent activity of many biologic agents in this disease have led to testing of biologic agent combinations. In this article, we review recent advances in the understanding of the molecular diversity of ovarian cancer as well as emerging therapeutic strategies such as new agents and biologic combinations that attempt to target multiple aberrant pathways in this cancer. (C)2014 AACR. C1 [Liu, Joyce; Matulonis, Ursula A.] Dana Farber Canc Inst, Dept Med Oncol, Gynecol Oncol Program, Boston, MA 02215 USA. RP Matulonis, UA (reprint author), Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA. EM ursula_matulonis@dfci.harvard.edu FU Ovarian Cancer Research Fund [258783]; Dana Farber Cancer Institute; Department of Defense Ovarian Cancer Award and Translational Project Award [W81XWH-12-1-0573, OC110627]; Ovarian Cancer Research Fund Program Project Grant Award [292970]; Breast Cancer Research Foundation grant FX J. Liu is supported by a Liz Tilberis Early Career Award from the Ovarian Cancer Research Fund (258783) and the Pallotta Investigator Fund from the Dana Farber Cancer Institute. U.A. Matulonis is supported by a Department of Defense Ovarian Cancer Award and Translational Project Award (W81XWH-12-1-0573 Log #OC110627), an Ovarian Cancer Research Fund Program Project Grant Award (292970), and a Breast Cancer Research Foundation 2013/2014 grant. NR 75 TC 23 Z9 23 U1 0 U2 10 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 EI 1557-3265 J9 CLIN CANCER RES JI Clin. Cancer Res. PD OCT 15 PY 2014 VL 20 IS 20 BP 5150 EP 5156 DI 10.1158/1078-0432.CCR-14-1312 PG 7 WC Oncology SC Oncology GA AR9DW UT WOS:000343873100002 PM 25320365 ER PT J AU Chattergoon, NN Louey, S Stork, PJ Giraud, GD Thornburg, KL AF Chattergoon, N. N. Louey, S. Stork, P. J. Giraud, G. D. Thornburg, K. L. TI Unexpected maturation of PI3K and MAPK-ERK signaling in fetal ovine cardiomyocytes SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE fetal heart; cardiomyocyte proliferation; thyroid hormone; MAPK; PI3K ID THYROID-HORMONE RECEPTOR; CELL-CYCLE ACTIVITY; CARDIAC MYOCYTES; DNA-SYNTHESIS; SHEEP FETUS; REGULATED KINASE; RAT MYOCARDIUM; NEONATAL-RAT; CROSS-TALK; C-FOS AB In the first two-thirds of gestation, ovine fetal cardiomyocytes undergo mitosis to increase cardiac mass and accommodate fetal growth. Thereafter, some myocytes continue to proliferate while others mature and terminally differentiate into binucleated cells. At term (145 days gestational age; dGA) about 60% of cardiomyocytes become binucleated and exit the cell cycle under hormonal control. Rising thyroid hormone (T-3) levels near term (135 dGA) inhibit proliferation and stimulate maturation. However, the degree to which intracellular signaling patterns change with age in response to T-3 is unknown. We hypothesized that in vitro activation of ERK, Akt, and p70(S6K) by two regulators of cardiomyocyte cell cycle activity, T-3 and insulin like growth factor-1 (IGF-1), would be similar in cardiomyocytes at gestational ages 100 and 135 dGA. IGF-1 and T-3 each independently stimulated phosphorylation of ERK, Akt, and p70(S6K) in cells at both ages. In the younger myocytes, the phosphorylation of ERK and Akt was reduced in the presence of IGF-1 and T-3. However, the same hormone combination led to a dramatic twofold increase in the phosphorylation of these signaling proteins in the 135 dGA cardiomyocytes-even in cells that were not proliferating. In the older cells, both mono- and binucleated cells were affected. In conclusion, fetal ovine cardiomyocytes undergo profound maturation-related changes in signaling in response to T-3 and IGF-1, but not to either factor alone. Differences in age-related response are likely to be related to milestones in fetal cardiac development as the myocardium prepares for ex utero life. C1 [Chattergoon, N. N.; Louey, S.; Stork, P. J.; Giraud, G. D.; Thornburg, K. L.] Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Ctr Dev Hlth, Portland, OR 97239 USA. [Louey, S.; Giraud, G. D.; Thornburg, K. L.] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97239 USA. [Stork, P. J.] Oregon Hlth & Sci Univ, Vollum Inst Adv Biomed Res, Portland, OR 97239 USA. [Giraud, G. D.] Portland VA Med Ctr, Portland, OR USA. RP Chattergoon, NN (reprint author), Oregon Hlth & Sci Univ, 3303 SW Bond Ave,CH15H, Portland, OR 97239 USA. EM chatterg@ohsu.edu FU National Institutes of Health [P01-HD-34430, R37-NS-045737, R01-HL-102763]; M. Lowell Edwards Endowment; National Heart, Lung, and Blood Institute [T32-HL-094294] FX This study was supported by National Institutes of Health Grants P01-HD-34430, R37-NS-045737, and R01-HL-102763. K. L. Thornburg was supported by the M. Lowell Edwards Endowment. N. N. Chattergoon was supported by National Heart, Lung, and Blood Institute Training Grant T32-HL-094294. NR 50 TC 7 Z9 7 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 EI 1522-1539 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD OCT 15 PY 2014 VL 307 IS 8 BP H1216 EP H1225 DI 10.1152/ajpheart.00833.2013 PG 10 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA AR0EY UT WOS:000343242400014 PM 25128174 ER PT J AU Bauer, KA Perez, KK Forrest, GN Goff, DA AF Bauer, Karri A. Perez, Katherine K. Forrest, Graeme N. Goff, Debra A. TI Review of Rapid Diagnostic Tests Used by Antimicrobial Stewardship Programs SO CLINICAL INFECTIOUS DISEASES LA English DT Review DE antimicrobial stewardship; rapid diagnostic test; outcomes; costs ID IN-SITU HYBRIDIZATION; POLYMERASE-CHAIN-REACTION; BLOOD-STREAM INFECTIONS; STAPHYLOCOCCUS-AUREUS BACTEREMIA; CLOSTRIDIUM-DIFFICILE INFECTION; GRAM-NEGATIVE BACTEREMIA; FLIGHT MASS-SPECTROMETRY; SEPTIC SHOCK; IMPACT; THERAPY AB Rapid microbiologic tests provide opportunities for antimicrobial stewardship programs to improve antimicrobial use and clinical and economic outcomes. Standard techniques for identification of organisms require at least 48-72 hours for final results, compared with rapid diagnostic tests that provide final organism identification within hours of growth. Importantly, rapid microbiologic tests are considered "game changers" and represent a significant advancement in the management of infectious diseases. This review focuses on currently available rapid diagnostic tests and, importantly, the impact of rapid testing in combination with antimicrobial stewardship on patient outcomes. C1 [Bauer, Karri A.; Goff, Debra A.] Ohio State Univ, Wexner Med Ctr, Dept Pharm, Columbus, OH 43210 USA. [Perez, Katherine K.] Houston Methodist Hosp, Dept Pharm, Houston, TX USA. [Perez, Katherine K.] Houston Methodist Hosp, Dept Pathol & Genom Med, Houston, TX USA. [Perez, Katherine K.] Houston Methodist Res Inst, Ctr Outcomes Res, Houston, TX USA. [Forrest, Graeme N.] Portland VA Med Ctr, Div Infect Dis, Portland, OR USA. RP Goff, DA (reprint author), Ohio State Univ, Wexner Med Ctr, Dept Pharm, Doan Hall,410 W 10th Ave,Rm 368, Columbus, OH 43210 USA. EM debbie.goff@osumc.edu FU Cubist Pharmaceuticals FX This article appears as part of a supplement titled "Antimicrobial Stewardship: Patients Over Process," sponsored by Cubist Pharmaceuticals. NR 42 TC 30 Z9 31 U1 2 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2014 VL 59 SU 3 BP S134 EP S145 DI 10.1093/cid/ciu547 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AR2KZ UT WOS:000343415900008 PM 25261540 ER PT J AU Forrest, GN Van Schooneveld, TC Kullar, R Schulz, LT Duong, P Postelnick, M AF Forrest, Graeme N. Van Schooneveld, Trevor C. Kullar, Ravina Schulz, Lucas T. Phu Duong Postelnick, Michael TI Use of Electronic Health Records and Clinical Decision Support Systems for Antimicrobial Stewardship SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE antimicrobial stewardship; clinical decision support system; electronic health record ID ORDER ENTRY SYSTEMS; ACUTE RESPIRATORY-INFECTIONS; RANDOMIZED CONTROLLED-TRIAL; INTENSIVE-CARE-UNIT; ANTIBIOTIC-TREATMENT; MEDICAL-RECORD; IMPACT; PROGRAM; SUSCEPTIBILITY; IMPLEMENTATION AB Electronic health records (EHRs) and clinical decision support systems (CDSSs) have the potential to enhance antimicrobial stewardship. Numerous EHRs and CDSSs are available and have the potential to enable all clinicians and antimicrobial stewardship programs (ASPs) to more efficiently review pharmacy, microbiology, and clinical data. Literature evaluating the impact of EHRs and CDSSs on patient outcomes is lacking, although EHRs with integrated CDSSs have demonstrated improvements in clinical and economic outcomes. Both technologies can be used to enhance existing ASPs and their implementation of core ASP strategies. Resolution of administrative, legal, and technical issues will enhance the acceptance and impact of these systems. EHR systems will increase in value when manufacturers include integrated ASP tools and CDSSs that do not require extensive commitment of information technology resources. Further research is needed to determine the true impact of current systems on ASP and the ultimate goal of improved patient outcomes through optimized antimicrobial use. C1 [Forrest, Graeme N.] Portland VA Med Ctr, Div Infect Dis, Portland, OR 97239 USA. [Van Schooneveld, Trevor C.] Univ Nebraska Med Ctr, Omaha, NE USA. [Kullar, Ravina; Phu Duong] Cubist Pharmaceut, Global Med Affairs, Lexington, MA USA. [Schulz, Lucas T.] Univ Wisconsin Hosp & Clin, Madison, WI 53792 USA. [Postelnick, Michael] NW Mem Hosp, Chicago, IL 60611 USA. RP Forrest, GN (reprint author), Portland VA Med Ctr, Div Infect Dis, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA. EM forrestg@ohsu.edu FU Cubist Pharmaceuticals FX This article appears as part of a supplement titled "Antimicrobial Stewardship: Patients Over Process," sponsored by Cubist Pharmaceuticals. NR 64 TC 15 Z9 15 U1 1 U2 13 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2014 VL 59 SU 3 BP S122 EP S133 DI 10.1093/cid/ciu565 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AR2KZ UT WOS:000343415900007 PM 25261539 ER PT J AU Lo Re, V Tate, JP Lim, JK Fiellin, DA Justice, AC AF Lo Re, Vincent, III Tate, Janet P. Lim, Joseph K. Fiellin, David A. Justice, Amy C. TI High Levels of Alcohol Consumption Increase the Risk of Advanced Hepatic Fibrosis in HIV/Hepatitis C Virus-Coinfected Patients: A Sex-Based Analysis Using Transient Elastography at Enrollment in the HEPAVIH ANRS CO13 Cohort Reply SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Lo Re, Vincent, III] Univ Penn, Philadelphia Vet Affairs Med Ctr, Philadelphia, PA 19104 USA. [Lo Re, Vincent, III] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Tate, Janet P.; Lim, Joseph K.; Justice, Amy C.] Vet Affairs Connecticut Healthcare Syst, West Haven, CT USA. [Tate, Janet P.; Lim, Joseph K.; Fiellin, David A.; Justice, Amy C.] Yale Univ, Sch Med, New Haven, CT USA. [Fiellin, David A.; Justice, Amy C.] Yale Univ, Sch Publ Hlth, Yale Ctr Interdisciplinary Res AIDS, New Haven, CT USA. RP Lo Re, V (reprint author), Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, 836 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM vincentl@mail.med.upenn.edu RI Lo Re, Vincent/N-7817-2015 NR 2 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2014 VL 59 IS 8 DI 10.1093/cid/ciu528 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AR2KG UT WOS:000343413200026 ER PT J AU Wiegman, AF Meier, IB Schupf, N Manly, JJ Guzman, VA Narkhede, A Stern, Y Martinez-Ramirez, S Viswanathan, A Luchsinger, JA Greenberg, SM Mayeux, R Brickman, AM AF Wiegman, Anne F. Meier, Irene B. Schupf, Nicole Manly, Jennifer J. Guzman, Vanessa A. Narkhede, Atul Stern, Yaakov Martinez-Ramirez, Sergi Viswanathan, Anand Luchsinger, Jose A. Greenberg, Steven M. Mayeux, Richard Brickman, Adam M. TI Cerebral microbleeds in a multiethnic elderly community: Demographic and clinical correlates SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article DE Cerebral microbleeds; Small-vessel disease; Multi-ethnic; Vascular risk factors; White matter hyperintensities; Stroke ID VASCULAR RISK-FACTORS; WHITE-MATTER LESIONS; AMYLOID ANGIOPATHY; ALZHEIMERS-DISEASE; BRAIN MICROBLEEDS; INTRACEREBRAL HEMORRHAGE; COGNITIVE FUNCTION; CARIBBEAN HISPANICS; NORTHERN MANHATTAN; AFRICAN-AMERICANS AB Background: Microbleeds, small perivascular collections of hemosiderin manifested radiologically as hypointensities on gradient-echo magnetic resonance imaging (MRI), are important markers of small vessel pathology. Despite their clinical relevance, little is known about their prevalence and demographic correlates, particularly among ethnically diverse older adults. We examined demographic and clinical correlates of regional microbleeds in a multi-ethnic cohort and examined categorization schemes of microbleed distribution and severity. Methods: Between 2005 and 2007, 769 individuals participated in a MRI study as part of the Washington Heights/Inwood Columbia Aging Project. Approximately four years later, 243 out of 339 participants (mean age = 84.50) who returned for a repeat MRI had gradient-echo scans for microbleed assessment and comprised the sample. We examined the association of deep and lobar microbleeds with age, sex, education, vascular factors, cognitive status and markers of small vessel disease. Results: Sixty-seven of the 243 (27%) participants had at least one microbleed. Individuals with microbleeds were more likely to have a history of stroke than individuals without. When categorized as having either no microbleeds, microbleeds in deep regions only, in lobar regions only, and both deep and lobar microbleeds, hypertension, proportion of strokes, and white matter hyperintensity volume (WMH) increased monotonically across the four groups. The number of lobar microbleeds correlated with WMH volume and diastolic blood pressure. Conclusions: Microbleeds in deep and lobar locations are associated with worse outcomes than microbleeds in either location alone, although the presence of lobar microbleeds appears to be more clinically relevant (C) 2014 Elsevier B.V. All rights reserved. C1 [Wiegman, Anne F.; Meier, Irene B.; Schupf, Nicole; Manly, Jennifer J.; Guzman, Vanessa A.; Narkhede, Atul; Stern, Yaakov; Mayeux, Richard; Brickman, Adam M.] Columbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA. [Schupf, Nicole; Manly, Jennifer J.; Stern, Yaakov; Mayeux, Richard; Brickman, Adam M.] Columbia Univ, Coll Phys & Surg, GH Sergievsky Ctr, New York, NY 10032 USA. [Schupf, Nicole; Luchsinger, Jose A.; Mayeux, Richard] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA. [Manly, Jennifer J.; Stern, Yaakov; Mayeux, Richard; Brickman, Adam M.] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA. [Martinez-Ramirez, Sergi; Viswanathan, Anand; Greenberg, Steven M.] Massachusetts Gen Hosp, Ctr Stroke Res, Boston, MA 02114 USA. [Luchsinger, Jose A.] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10032 USA. RP Brickman, AM (reprint author), Columbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, PS Box 16,630 West 168th St, New York, NY 10032 USA. EM amb2139@columbia.edu FU National Institutes of Health [AG034189, AG037212] FX This study was sponsored by grants from the National Institutes of Health (AG034189 and AG037212). NR 56 TC 9 Z9 10 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X EI 1878-5883 J9 J NEUROL SCI JI J. Neurol. Sci. PD OCT 15 PY 2014 VL 345 IS 1-2 BP 125 EP 130 DI 10.1016/j.jns.2014.07.024 PG 6 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AR6JJ UT WOS:000343689600019 PM 25091451 ER PT J AU Robertson, RP Raymond, RH Lee, DS Calle, RA Ghosh, A Savage, PJ Shankar, SS Vassileva, MT Weir, GC Fryburg, DA AF Robertson, R. Paul Raymond, Ralph H. Lee, Douglas S. Calle, Roberto A. Ghosh, Atalanta Savage, Peter J. Shankar, Sudha S. Vassileva, Maria T. Weir, Gordon C. Fryburg, David A. CA Fdn NIH Biomarkers Consortium TI Arginine is preferred to glucagon for stimulation testing of beta-cell function SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM LA English DT Article DE arginine; glucagon; beta-cell function; insulin secretion ID C-PEPTIDE RESPONSE; INTENSIVE INSULIN THERAPY; DOSE-RESPONSE; INTRAVENOUS GLUCAGON; SECRETORY RESERVE; DIABETIC-PATIENTS; GLYCEMIC CONTROL; IN-VIVO; MASS; GLUCOSE AB A key aspect of research into the prevention and treatment of type 2 diabetes is the availability of reproducible clinical research methodology to assess beta-cell function. One commonly used method employs nonglycemic secretagogues like arginine (arg) or glucagon (glgn). This study was designed to quantify the insulin response to arg and glgn and determine test repeatability and tolerability. Obese over-night-fasted subjects with normal glucose tolerance were studied on 4 separate days: twice using arg (5 g iv) and twice with glgn (1 mg iv). Pre- and postinfusion samples for plasma glucose, insulin, and C-peptide were acquired. Arg and glgn challenges were repeated in the last 10 min of a 60-min glucose (900 mg/min) infusion. Insulin and C-peptide secretory responses were estimated under baseline fasting glucose conditions (AIRarg and AIRglgn) and hyperglycemic (AIRargMAX AIRglgnMAX) states. Relative repeatability was estimated by intraclass correlation coefficient (ICC). Twenty-three (12 men and 11 women) subjects were studied (age: 42.4 +/- 8.3 yr; BMI: 31.4 +/- 2.8 kg/m(2)). Geometric means (95% CI) for baseline-adjusted values AIRarg and AIRglgn were 84 (75-95) and 102 (90 -115) mu U/ml, respectively. After the glucose infusion, AIRargMAX and AIRglgnMAX were 395 (335-466) and 483 (355-658) mu U/ml, respectively. ICC values were >0.90 for AIRarg andAIRargMAX. Glucagon ICCs were 0.83, 0.34, and 0.36, respectively, although the exclusion of one outlier increased the latter two values (to 0.84 and 0.86). Both glgn and arg induced mild adverse events that were transient. Glucagon, but not arginine, induced moderate adverse events due to nausea. Taken together, arginine is preferred to glucagon for assessment of beta-cell function. C1 [Robertson, R. Paul] Pacific Northwest Diabet Res Inst, Seattle, WA USA. [Raymond, Ralph H.] R Squared Solut, Skillman, NJ USA. [Lee, Douglas S.; Calle, Roberto A.] Pfizer Inc, Groton, CT 06340 USA. [Ghosh, Atalanta] Janssen Res & Dev, Raritan, NJ USA. [Savage, Peter J.] NIDDK, NIH, Bethesda, MD 20892 USA. [Shankar, Sudha S.] Eli Lilly & Co, Indianapolis, IN 46285 USA. [Vassileva, Maria T.] Fdn Natl Inst Hlth, Bethesda, MD USA. [Weir, Gordon C.] Joslin Diabet Ctr, Boston, MA 02215 USA. [Fryburg, David A.] ROI BioPharma Consulting, East Lyme, CT 06333 USA. RP Fryburg, DA (reprint author), ROI BioPharma Consulting, 14 Alexander Dr, East Lyme, CT 06333 USA. EM dfryburg@roibiopharma.com FU NIH (NIDDK); FDA; Bristol-Meyers; Janssen; Eli Lilly and Co.; Merck; Novartis; Novo Nordisk; Pfizer; Sanofi; Takeda FX The methodological study described in this report was designed and implemented under the auspices of the FNIH Biomarkers Consortium. The Biomarkers Consortium is a public/private partnership that develops, validates, and qualifies biological markers aimed ultimately at improving clinical research and patient care. For this study, the Consortium brought together diabetes experts from leading academic institutions, the Food and Drug Administration, the NIH, the nonprofit sector, and the pharmaceutical industry to develop the project. This project was jointly funded by the NIH (NIDDK) and FDA and the following pharmaceutical companies: Amylin (now Bristol-Meyers), Janssen, Eli Lilly and Co., Merck, Novartis, Novo Nordisk, Pfizer, Sanofi, and Takeda. P800 tubes were generously donated by Becton-Dickinson. NR 40 TC 6 Z9 7 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1849 EI 1522-1555 J9 AM J PHYSIOL-ENDOC M JI Am. J. Physiol.-Endocrinol. Metab. PD OCT 15 PY 2014 VL 307 IS 8 BP E720 EP E727 DI 10.1152/ajpendo.00149.2014 PG 8 WC Endocrinology & Metabolism; Physiology SC Endocrinology & Metabolism; Physiology GA AR0AI UT WOS:000343223700011 PM 25159323 ER PT J AU Ahluwalia, N Shea, BS Tager, AM AF Ahluwalia, Neil Shea, Barry S. Tager, Andrew M. TI New Therapeutic Targets in Idiopathic Pulmonary Fibrosis Aiming to Rein in Runaway Wound-Healing Responses SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE idiopathic pulmonary fibrosis; pathogenesis; investigational treatments ID GROWTH-FACTOR-BETA; PLACEBO-CONTROLLED TRIAL; OBSTRUCTIVE SLEEP-APNEA; SURFACTANT PROTEIN-C; ACID GASTROESOPHAGEAL-REFLUX; ACTIVATES LATENT TGF-BETA-1; BLEOMYCIN HAMSTER MODEL; INDUCED LUNG FIBROSIS; RANDOMIZED-TRIAL; TGF-BETA AB Idiopathic pulmonary fibrosis (IPF) is a devastating disease, with a median survival as short as 3 years from the time of diagnosis and no pharmacological therapies yet approved by the U.S. Food and Drug Administration. To address the great unmet need for effective IPF therapy, a number of new drugs have recently been, or are now being, evaluated in clinical trials. The rationales for most of these therapeutic candidates are based on the current paradigm of IPF pathogenesis, in which recurrent injury to the alveolar epithelium is believed to drive aberrant wound healing responses, resulting in fibrosis rather than repair. Here we discuss drugs in recently completed or currently ongoing phase II and III IPF clinical trials in the context of their putative mechanisms of action and the aberrant repair processes they are believed to target: innate immune activation and polarization, fibroblast accumulation and myofibroblast differentiation, or extracellular matrix deposition and stiffening. Placed in this context, the positive results of recently completed trials of pirfenidone and nintedanib, and results that will come from ongoing trials of other agents, should provide valuable insights into the still-enigmatic pathogenesis of this disease, in addition to providing benefits to patients with IPF. C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Pulm & Crit Care Unit, Boston, MA USA. Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Immunol & Inflammatory Dis, Boston, MA USA. RP Tager, AM (reprint author), Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, 149 13th St,Room 8301, Charlestown, MA 02129 USA. EM amtager@mgh.harvard.edu FU National Institutes of Health/National Heart, Lung, and Blood Institute [T32HL116275, K08HL105656, R01HL095732, R01HL108975]; Nirenberg Center for Advanced Lung Disease; Scleroderma Research Foundation; Boehringer Ingelheim Pharmaceuticals, Inc.; Wendy Morris of Fleishman-Hillard Group, Ltd FX Supported by National Institutes of Health/National Heart, Lung, and Blood Institute grants T32HL116275 (N.A.), K08HL105656 (B.S.S.), R01HL095732, and R01HL108975 (A.M.T.), and a grant from the Nirenberg Center for Advanced Lung Disease and the Scleroderma Research Foundation (A.M.T.). Medical writing assistance, supported financially by Boehringer Ingelheim Pharmaceuticals, Inc., was provided by Wendy Morris of Fleishman-Hillard Group, Ltd during the preparation of this manuscript. NR 145 TC 44 Z9 44 U1 0 U2 17 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD OCT 15 PY 2014 VL 190 IS 8 BP 867 EP 878 DI 10.1164/rccm.201403-0509PP PG 12 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AR1XJ UT WOS:000343377600006 PM 25090037 ER PT J AU Shenton, ME Kubicki, M Makris, N AF Shenton, Martha E. Kubicki, Marek Makris, Nikos TI Understanding Alterations in Brain Connectivity in Attention-Deficit/Hyperactivity Disorder Using Imaging Connectomics COMMENTARY SO BIOLOGICAL PSYCHIATRY LA English DT Editorial Material C1 [Shenton, Martha E.; Kubicki, Marek] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Shenton, Martha E.; Kubicki, Marek; Makris, Nikos] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA. [Shenton, Martha E.] Dept Vet Affairs Boston Healthcare Syst, Brockton Div, Brockton, MA USA. [Makris, Nikos] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Makris, Nikos] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. RP Shenton, ME (reprint author), Psychiat Neuroimaging Lab, 1249 Boylston St, Boston, MA 02215 USA. EM Shenton@bwh.harvard.edu FU NIA NIH HHS [R01AG042512]; NIBIB NIH HHS [R21EB016449]; NIMH NIH HHS [R01 MH074794, R01 MH102377]; NINDS NIH HHS [R21NS079905] NR 8 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD OCT 15 PY 2014 VL 76 IS 8 BP 601 EP 602 DI 10.1016/j.biopsych.2014.08.018 PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA AQ8QL UT WOS:000343094400005 PM 25262232 ER PT J AU Ferdman, J Porcheray, F Gao, BS Moore, C DeVito, J Dougherty, S Thomas, MV Farkash, EA Elias, N Kawai, T Malek, SK Tullius, SG Wong, WC Zorn, E AF Ferdman, Jack Porcheray, Fabrice Gao, Baoshan Moore, Carolina DeVito, Julie Dougherty, Sarah Thomas, Margaret V. Farkash, Evan A. Elias, Nahel Kawai, Tatsuo Malek, Sayeed K. Tullius, Stefan G. Wong, Waichi Zorn, Emmanuel TI Expansion and Somatic Hypermutation of B-cell Clones in Rejected Human Kidney Grafts SO TRANSPLANTATION LA English DT Article DE Infiltrating B cells; Graft rejection; Kidney allografts ID RENAL-ALLOGRAFT REJECTION; TRANSPLANTED HUMAN KIDNEYS; TERTIARY LYMPHOID ORGANS; RITUXIMAB; CLUSTERS; INFLAMMATION; TRANSCRIPTS; NEOGENESIS; SURVIVAL; THERAPY AB Background. B-cell infiltrates are common in rejected kidney allografts, yet their composition is still unclear. The aim of our study was to characterize the clonal composition of B-cell infiltrates of rejected human kidney grafts. Methods. We used a molecular approach to characterize the partial B-cell repertoires of 5 failed human kidney grafts with detectable B-cell infiltrates. A comparison between the intragraft and blood repertoire was also conducted for 1 case. Results. Redundant sequences were observed in both blood and graft, although the level of clonal amplification was significantly higher for the graft. Somatic hypermutations (SHMs) were also more frequent in sequences found in the graft compared to the blood. The rate of nonsilent mutations was significantly higher in complementarity determining regions (CDRs) compared to framework regions in blood sequences as well as in graft sequences found at low frequency. In contrast, this preferential distribution was lost in sequences found at high frequency in the graft, suggesting a lack of affinity maturation in situ. Lastly, follicular dendritic cells were undetectable in CD20(+) infiltrates in all samples examined. Conclusions. We provide here evidence that B-cell clones expand and undergo SHMs in situ. However, the even distribution of nonsilent SHM in high-frequency graft sequences together with the absence of follicular dendritic cells do not support the view that infiltrating B cells are part of functional germinal centers. C1 [Ferdman, Jack; Porcheray, Fabrice; Gao, Baoshan; Moore, Carolina; DeVito, Julie; Dougherty, Sarah; Thomas, Margaret V.; Elias, Nahel; Kawai, Tatsuo; Zorn, Emmanuel] Harvard Univ, Sch Med, Dept Surg, Transplant Ctr,Massachusetts Gen Hosp, Boston, MA 02115 USA. [Gao, Baoshan] Jilin Univ, Hosp 1, Transplant Ctr, Changchun 130023, Peoples R China. [Farkash, Evan A.] Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Malek, Sayeed K.; Tullius, Stefan G.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Transplant Surg, Boston, MA 02115 USA. [Wong, Waichi] Harvard Univ, Sch Med, Dept Med, Renal Unit,Massachusetts Gen Hosp, Boston, MA USA. RP Zorn, E (reprint author), Massachusetts Gen Hosp, Transplant Ctr, Thier 807,55 Fruit St, Boston, MA 02114 USA. EM ezorn@partners.org FU Fahd and Nadia Alireza's Research Fund; Roche Organ Transplantation Research Foundation; National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases [DK083352]; National Institute of Allergy and Infectious Diseases [AI94524] FX This work was supported by the Fahd and Nadia Alireza's Research Fund, the Roche Organ Transplantation Research Foundation, and the National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases (Grant No. DK083352) and National Institute of Allergy and Infectious Diseases (Grant No. AI94524). NR 31 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 EI 1534-6080 J9 TRANSPLANTATION JI Transplantation PD OCT 15 PY 2014 VL 98 IS 7 BP 766 EP 772 DI 10.1097/TP.0000000000000124 PG 7 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA AR1FC UT WOS:000343328900019 PM 24825521 ER PT J AU Prasad, P Fishman, JA AF Prasad, Paritosh Fishman, Jay A. TI Impact and Cost of the Serum Galactomannan Assay at a Tertiary Care Facility SO TRANSPLANTATION LA English DT Article DE Galactomannan; Aspergillosis; Invasive fungal infection ID INVASIVE ASPERGILLOSIS; PULMONARY ASPERGILLOSIS; TRANSPLANT RECIPIENTS; ENZYME-IMMUNOASSAY; DIAGNOSIS; INFECTIONS; EPIDEMIOLOGY; ANTIGENEMIA; AMERICA; DISEASE AB Background. Invasive aspergillosis carries a high mortality with a rising prevalence in immunocompromised hosts. Diagnosis of invasive aspergillosis is challenging and delays in treatment are associated with poor outcomes. The galactomannan assay (GM), a non-culture-based surrogate marker of fungal infection, is widely used in diagnosis. It is unknown whether this assay impacts clinical decision making. We evaluated whether GM testing results in earlier initiation of antifungal therapy and is cost effective. Methods. We carried out a retrospective review of the electronic medical records of all patients undergoing GM at a 907-bed tertiary-care general hospital from July 11, 2011, to June 12, 2012. Records of patients with a positive GM were individually reviewed to determine the timing of the assay result, presence and timing of relevant culture data, whether BAL GM was performed, radiology data consistent with invasive aspergillosis, and the timing of initiation of antifungal therapy. For each case, it was determined whether GM results impacted the decision to initiate antifungal therapy. Results. Forty-six nonduplicate GM samples were positive (>0.5) of 1419 performed. Results were considered to be false positives in 18 cases by care teams. In 21 cases, antifungal therapy was initiated before the assay result based on clinical suspicion, culture data, and/or radiology. The serum GM was performed 164 times at a cost of $21,789 for a single positive result effecting modification of patient care. Conclusion. Serum GM testing at a tertiary-care institution is commonly used but infrequently impacts clinical decision making with major financial burden. C1 [Prasad, Paritosh] Univ Rochester, Med Ctr, Dept Pulm & Crit Care, Rochester, NY 14642 USA. [Prasad, Paritosh] Univ Rochester, Med Ctr, Dept Infect Dis, Rochester, NY 14642 USA. [Fishman, Jay A.] Massachusetts Gen Hosp, Div Infect Dis, Transplant Ctr, Transplant Infect Dis & Immunocompromised Host Pr, Boston, MA 02114 USA. [Fishman, Jay A.] Harvard Univ, Sch Med, Boston, MA USA. RP Prasad, P (reprint author), Univ Rochester, Med Ctr, Dept Pulm & Crit Care, 601 Elmwood Ave,Box 692, Rochester, NY 14642 USA. EM paritosh_prasad@urmc.rochester.edu FU Massachusetts General Hospital Transplant Infectious Disease and Compromised Host Program FX This research was carried out with funding from the Massachusetts General Hospital Transplant Infectious Disease and Compromised Host Program. NR 19 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 EI 1534-6080 J9 TRANSPLANTATION JI Transplantation PD OCT 15 PY 2014 VL 98 IS 7 BP 773 EP 780 DI 10.1097/TP.0000000000000131 PG 8 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA AR1FC UT WOS:000343328900020 PM 24825524 ER PT J AU Yamada, K Tasaki, M Sekijima, M Wilkinson, RA Villani, V Moran, SG Cormack, TA Hanekamp, IM Hawley, RJ Arn, JS Fishman, JA Shimizu, A Sachs, DH AF Yamada, Kazuhiko Tasaki, Masayuki Sekijima, Mitsuhiro Wilkinson, Robert A. Villani, Vincenzo Moran, Shannon G. Cormack, Taylor A. Hanekamp, Isabel M. Hawley, Robert J. Arn, J. Scott Fishman, Jay A. Shimizu, Akira Sachs, David H. TI Porcine Cytomegalovirus Infection Is Associated With Early Rejection of Kidney Grafts in a Pig to Baboon Xenotransplantation Model (vol 98, pg 411, 2014) SO TRANSPLANTATION LA English DT Correction C1 [Yamada, Kazuhiko] Massachusetts Gen Hosp, Organ Transplantat Tolerance & Xenotransplantat L, Transplantat Biol Res Ctr, Boston, MA 02114 USA. RP Yamada, K (reprint author), Massachusetts Gen Hosp, Organ Transplantat Tolerance & Xenotransplantat L, Transplantat Biol Res Ctr, MGH East,Bldg 149-9019,13th St, Boston, MA 02114 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 EI 1534-6080 J9 TRANSPLANTATION JI Transplantation PD OCT 15 PY 2014 VL 98 IS 7 BP E77 EP E77 PG 1 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA AR1FC UT WOS:000343328900006 ER PT J AU Jarvie, JL Whooley, MA Regan, MC Sin, NL Cohen, BE AF Jarvie, Jennifer L. Whooley, Mary A. Regan, Mathilda C. Sin, Nancy L. Cohen, Beth E. TI Effect of Physical Activity Level on Biomarkers of Inflammation and Insulin Resistance Over 5 Years in Outpatients With Coronary Heart Disease (from the Heart and Soul Study) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; CONSTRUCT-VALIDITY; CHOLESTEROL; MEN; FITNESS; COHORT; WOMEN AB Higher levels of physical activity are associated with lower rates of coronary heart disease (CHD). Previous studies have suggested that this is due partly to lower levels of inflammation and insulin resistance. The aim of this study was to determine whether physical activity level was associated with inflammation or insulin resistance during a 5-year period in outpatients with known CHD. A total of 656 participants from the Heart and Soul Study, a prospective cohort study of outpatients with documented CHD, were evaluated. Self-reported physical activity frequency was assessed at baseline and after 5 years of follow-up. Participants were.classified as low versus high activity at each visit, yielding 4 physical activity groups: stable low activity, decreasing activity (high at baseline to low at year 5), increasing activity (low at baseline to high at year 5), and stable high activity. Year 5 markers of inflammation (C-reactive protein [CRP], interleulen-6, and fibrinogen) and insulin resistance (insulin, glucose, and glycated hemoglobin) were compared across the 4 activity groups. After 5 years of follow-up, higher activity was associated with lower mean levels of all biomarkers. In the fully adjusted regression models, CRP, interleukin-6, and glucose remained independently associated with physical activity frequency (log CRP, p for trend across activity groups = 0.03; log interleukin-6, p for trend = 0.01; log glucose, p for trend = 0.003). Subjects with stable high activity typically had the lowest levels of biomarkers. In conclusion, in this novel population of outpatients with known CHD followed for 5 years, higher physical activity frequency was independently associated with lower levels of CRP, interleukin-6, and glucose. (C) 2014 Elsevier Inc. All rights reserved. C1 [Jarvie, Jennifer L.; Whooley, Mary A.; Cohen, Beth E.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Whooley, Mary A.; Regan, Mathilda C.; Cohen, Beth E.] San Francisco VA Med Ctr, Dept Med, San Francisco, CA USA. [Sin, Nancy L.] Penn State Univ, Ctr Hlth Aging, University Pk, PA 16802 USA. RP Cohen, BE (reprint author), Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. EM beth.cohen@ucsf.edu RI Sin, Nancy/M-4164-2014 OI Sin, Nancy/0000-0003-2519-7797 FU National Heart, Lung, and Blood Institute, Bethesda, Maryland [K23 HL 09476]; American Heart Association, Dallas, Texas [12CRP11810021]; National Institute on Aging, Bethesda, Maryland [T32 AG000212]; Department of Veterans Affairs, Washington, District of Columbia; National Heart, Lung, and Blood Institute [R01 HL079235]; American Federation for Aging Research (Paul Beeson Scholars Program), New York, New York; Robert Wood Johnson Foundation (Faculty Scholars Program), Princeton, New Jersey; Ischemia Research and Education Foundation, South San Francisco, California; Nancy Kirwan Heart Research Fund, San Francisco, California FX Dr. Cohen was supported by Grant K23 HL 09476 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland, and Grant 12CRP11810021 from the American Heart Association, Dallas, Texas. Dr.. Sin was supported by Institutional Training Grant T32 AG000212 from the National Institute on Aging, Bethesda, Maryland. The Heart and Soul Study was funded by the Department of Veterans Affairs, Washington, District of Columbia; grant R01 HL079235 from the National Heart, Lung, and Blood Institute; the American Federation for Aging Research (Paul Beeson Scholars Program), New York, New York; the Robert Wood Johnson Foundation (Faculty Scholars Program), Princeton, New Jersey; the Ischemia Research and Education Foundation, South San Francisco, California; and the Nancy Kirwan Heart Research Fund, San Francisco, California. NR 20 TC 7 Z9 8 U1 0 U2 4 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 EI 1879-1913 J9 AM J CARDIOL JI Am. J. Cardiol. PD OCT 15 PY 2014 VL 114 IS 8 BP 1192 EP 1197 DI 10.1016/j.amjcard.2014.07.036 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AQ7TE UT WOS:000343021300010 PM 25173442 ER PT J AU Fatemi, O Yuriditsky, E Tsioufis, C Tsachris, D Morgan, T Basile, J Bigger, T Cushman, W Goff, D Soliman, EZ Thomas, A Papademetriou, V AF Fatemi, Omid Yuriditsky, Eugene Tsioufis, Costas Tsachris, Demetrios Morgan, Timothy Basile, Jan Bigger, Thomas Cushman, William Goff, David Soliman, Elsayed Z. Thomas, Abraham Papademetriou, Vasilios TI Impact of Intensive Glycemic Control on the Incidence of Atrial Fibrillation and Associated Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (from the Action to Control Cardiovascular Risk in Diabetes Study) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID INDEPENDENT RISK; ACCORD TRIAL; HYPOGLYCEMIA; METAANALYSIS; DISEASE; COHORT AB Atrial fibrillation (AF) is prevalent in patients with type 2 diabetes mellitus (DM) and is associated with markers of poor glycemic control; however, the impact of glycemic control on incident AF and outcomes is unknown. The aims of this study were to prospectively evaluate if intensive glycemic control in patients with DM affects incident AF and to evaluate morbidity and mortality in patients with DM and incident AF. A total of 10,082 patients with DM from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) cohort were studied in a randomized, double-blind fashion. Participants were randomized to an intensive therapeutic strategy targeting a glycated hemoglobin level of <6.0% or a standard strategy targeting a glycated hemoglobin level of 7.0% to 7.9%. Incident AF occurred in 159 patients (1.58%) over the follow-up period, at a rate of 5.9 per 1,000 patient-years in the intensive-therapy group and a rate of 6.37 per 1,000 patient-years in the standard-therapy group (p = 0.52). In a multivariate model, predictors of incident AF were age, weight, diastolic blood pressure, heart rate, and heart failure history. Patients with DM and new-onset AF had a hazard ratio of 2.65 for all-cause mortality (95% confidence interval 1.8 to 3.86, p <0.0001), a hazard ratio of 2.1 for myocardial infarction (95% confidence interval 1.33 to 3.31, p = 0.0015), and a hazard ratio of 3.80 for the development of heart failure (95% confidence interval 2.48 to 5.84, p <0.0001). In conclusion, intensive glycemic control did not affect the rate of new-onset AF. Patients with DM and incident AF had an increased risk for morbidity and mortality compared with those without AF. (C) 2014 Elsevier Inc. All rights reserved. C1 [Fatemi, Omid; Yuriditsky, Eugene] Washington Hosp Ctr, Washington, DC 20010 USA. [Fatemi, Omid; Yuriditsky, Eugene; Papademetriou, Vasilios] Georgetown Univ Hosp, Washington, DC 20007 USA. [Fatemi, Omid; Yuriditsky, Eugene; Papademetriou, Vasilios] Washington DC Vet Med Ctr, Washington, DC USA. [Tsioufis, Costas; Tsachris, Demetrios] Univ Athens, Hippokrat Hosp, Athens, Greece. [Morgan, Timothy; Soliman, Elsayed Z.] Wake Forest Baptist Med Ctr, Winston Salem, NC USA. [Basile, Jan] Med Univ S Carolina, Charleston, SC 29425 USA. [Basile, Jan] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Bigger, Thomas] Columbia Univ, Med Ctr, New York, NY USA. [Cushman, William] Univ Tennessee, Hlth Sci Ctr, Memphis, TN USA. [Goff, David] Colorado Sch Publ Hlth, Aurora, CO USA. [Thomas, Abraham] Henry Ford Hlth Syst, Detroit, MI USA. RP Yuriditsky, E (reprint author), Washington Hosp Ctr, Washington, DC 20010 USA. EM eugene.yuriditsky@gmail.com OI Yuriditsky, Eugene/0000-0003-2263-9297; Thomas, Abraham/0000-0002-3941-1195; Papademetriou, Vasilios/0000-0002-2882-2757 FU National Heart, Lung, and Blood Institute, Bethesda, Maryland [Y01 HC001010] FX This study was funded by the National Heart, Lung, and Blood Institute (grant number Y01 HC001010), Bethesda, Maryland (ClinicalTrials.gov identifier NCT00000620). NR 27 TC 20 Z9 20 U1 1 U2 8 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 EI 1879-1913 J9 AM J CARDIOL JI Am. J. Cardiol. PD OCT 15 PY 2014 VL 114 IS 8 BP 1217 EP 1222 DI 10.1016/j.amjcard.2014.07.045 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AQ7TE UT WOS:000343021300015 PM 25159234 ER PT J AU Heist, EK Herre, JM Binkley, PF Van Bakel, AB Porterfield, JG Porterfield, LM Qu, FJ Turkel, M Pavri, BB AF Heist, E. Kevin Herre, John M. Binkley, Philip F. Van Bakel, Adrian B. Porterfield, James G. Porterfield, Linda M. Qu, Fujian Turkel, Melanie Pavri, Behzad B. CA DEFEAT-PE Study Investigators TI Analysis of Different Device-Based Intrathoracic Impedance Vectors for Detection of Heart Failure Events (from the Detect Fluid Early from Intrathoracic Impedance Monitoring Study) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID PREDICTIVE-VALUE; RISK; HOSPITALIZATIONS; DETERIORATION; FEASIBILITY; CONGESTION; SYMPTOMS; UTILITY; TRIAL AB Detect Fluid Early from Intrathoracic Impedance Monitoring (DEFEAT-PE) is a prospective, multicenter study of multiple intrathoracic impedance vectors to detect pulmonary congestion (PC) events. Changes in intrathoracic impedance between the right ventricular (RV) coil and device can (RVcoil -> Can) of implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy ICDs (CRT-Ds) are used clinically for the detection of PC events, but other impedance vectors and algorithms have not been studied prospectively. An initial 75-patient study was used to derive optimal impedance vectors to detect PC events, with 2 vector combinations selected for prospective analysis in DEFEAT-PE (ICD vectors: RVring -> Can + RVcoil -> Can, detection threshold 13 days; CRT-D vectors: left ventricular ring -> Can + RVcoil -> Can, detection threshold 14 days). Impedance changes were considered true positive if detected <30 days before an adjudicated PC event. One hundred sixty-two patients were enrolled (80 with ICDs and 82 with CRT-Ds), all with >= 1 previous PC event. One hundred forty-four patients provided study data, with 214 patient-years of follow-up and 139 PC events. Sensitivity for PC events of the prespecified algorithms was as follows: ICD: sensitivity 32.3%, false-positive rate 1.28 per patient-year; CRT-D: sensitivity 32.4%, false-positive rate 1.66 per patient-year. An alternative algorithm, ultimately approved by the US Food and Drug Administration (RVring -> Can + RVcoil -> Can, detection threshold 14 days), resulted in (for all patients) sensitivity of 21.6% and a false-positive rate of 0.9 per patient-year. The CRT-D thoracic impedance vector algorithm selected in the derivation study was not superior to the ICD algorithm RVring -> Can + RVcoil -> Can when studied prospectively. In conclusion, to achieve an acceptably low false-positive rate, the intrathoracic impedance algorithms studied in DEFEAT-PE resulted in low sensitivity for the prediction of heart failure events. (C) 2014 Elsevier Inc. All rights reserved. C1 [Heist, E. Kevin] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA. [Herre, John M.] Eastern Virginia Med Hosp, Norfolk, VA USA. [Herre, John M.] Sentara Norfolk Gen Hosp, Norfolk, VA USA. [Binkley, Philip F.] Ohio State Univ, Div Cardiovasc Med, Columbus, OH 43210 USA. [Binkley, Philip F.] Ohio State Univ, Davis Heart & Lung Inst, Columbus, OH 43210 USA. [Van Bakel, Adrian B.] Med Univ S Carolina, Charleston, SC 29425 USA. [Porterfield, James G.; Porterfield, Linda M.] Methodist Univ Hosp, Memphis, TN USA. [Qu, Fujian; Turkel, Melanie] St Jude Med, Sylmar, CA USA. [Pavri, Behzad B.] Thomas Jefferson Univ, Sch Med, Philadelphia, PA 19107 USA. RP Heist, EK (reprint author), Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA. EM kheist@partners.org FU Biotronik; Sorin; St. Jude Medical; Medtronic; Boston Scientific FX Dr. Heist is a consultant for and has received a research grant from Biotronik, is a consultant for Boston Scientific, has received a research grant from Sorin, and is a consultant for and has received a research grant from St. Jude Medical., Dr. Herre has received a research grant from St. Jude Medical. Dr. Binkley is a consultant for St. Jude Medical. Dr. Van Bakel has received a research grant from Medtronic as is a consultant for St. Jude Medical. Dr. J.G. Porterfield has received a research grant from St. Jude Medical. Dr. L.M. Porterfield has received a research grant from St. Jude Medical. Dr. Qu is an employee of St. Jude Medical. Ms. Turkel is an employee of St. Jude Medical. Dr. Pavri is a speaker for Biotronik, has received grant support from Boston Scientific, is a speaker for and has received grant support from Medtronic, and is a consultant for St. Jude Medical. NR 20 TC 8 Z9 8 U1 0 U2 2 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 EI 1879-1913 J9 AM J CARDIOL JI Am. J. Cardiol. PD OCT 15 PY 2014 VL 114 IS 8 BP 1249 EP 1256 DI 10.1016/j.amjcard.2014.07.048 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AQ7TE UT WOS:000343021300021 PM 25150135 ER PT J AU George, S Barysauskas, C Serrano, C Oduyebo, T Rauh-Hain, JA Del Carmen, MG Demetri, GD Muto, MG AF George, Suzanne Barysauskas, Constance Serrano, Cesar Oduyebo, Titilope Rauh-Hain, Jose A. Del Carmen, Marcela G. Demetri, George D. Muto, Michael G. TI Retrospective Cohort Study Evaluating the Impact of Intraperitoneal Morcellation on Outcomes of Localized Uterine Leiomyosarcoma SO CANCER LA English DT Article DE uterine leiomyosarcoma; uterine sarcoma; morcellation; hysterectomy; outcomes ID SUPRACERVICAL HYSTERECTOMY; TUMOR MORCELLATION; SURGICAL-PROCEDURE; LEIOMYOMAS; SARCOMAS; PROGNOSIS; SURVIVAL; SURGERY AB BACKGROUND: Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in inadvertently morcellated ULMS with resultant intraperitoneal dissemination of tumor. The objective of this study was to assess the impact of intraperitoneal morcellation on the outcomes of patients with ULMS. METHODS: In this retrospective cohort study, all patients with ULMS who attended the authors' institutions from 2007 to 2012 were reviewed. Demographics and outcomes were compared between those who underwent morcellation or total abdominal hysterectomy (TAH) as their first surgery for uterus-limited ULMS. RESULTS: In total, 58 patients were identified, including 39 who underwent TAH and 19 who underwent intraperitoneal morcellation. Intraperitoneal morcellation was associated with a significantly increased risk of abdominal/pelvic recurrences (P=.001) and with significantly shorter median recurrence-free survival (10.8 months vs 39.6 months; P=.002). A multivariate adjusted model demonstrated a > 3 times increased risk of recurrence associated with morcellation (hazard ratio, 3.18; 95% confidence interval, 1.5-6.8; P=.003). CONCLUSIONS: Intraperitoneal morcellation of presumed leiomyoma worsens the outcomes of women with ULMS. Because there are no reliable preoperative techniques to distinguish ULMS from benign leiomyoma, all efforts to minimize intraperitoneal uterine morcellation should be considered. [ See editorial on pages 000-000, this issue.] (C) 2014 American Cancer Society. C1 [George, Suzanne; Serrano, Cesar; Demetri, George D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Sarcoma & Bone Oncol, Boston, MA 02115 USA. [Barysauskas, Constance] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Oduyebo, Titilope; Muto, Michael G.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Gynecol Oncol,Dept Obstet & Gynecol, Boston, MA 02115 USA. [Oduyebo, Titilope; Rauh-Hain, Jose A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Gynecol Oncol,Vincent Obstet & Gynecol, Boston, MA USA. RP George, S (reprint author), Dana Farber Canc Inst, Ctr Sarcoma & Bone Oncol, 450 Brookline Ave, Boston, MA 02215 USA. EM sgeorge2@partners.org FU Driscoll Family Leiomyosarcoma Fund FX Dr. George was supported by funding from the Driscoll Family Leiomyosarcoma Fund. NR 24 TC 42 Z9 44 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD OCT 15 PY 2014 VL 120 IS 20 BP 3154 EP 3158 DI 10.1002/cncr.28844 PG 5 WC Oncology SC Oncology GA AQ6GQ UT WOS:000342908800011 PM 24923260 ER PT J AU John, DA Kawachi, I Lathan, CS Ayanian, JZ AF John, Dolly A. Kawachi, Ichiro Lathan, Christopher S. Ayanian, John Z. TI Disparities in Perceived Unmet Need for Supportive Services Among Patients With Lung Cancer in the Cancer Care Outcomes Research and Surveillance Consortium SO CANCER LA English DT Article DE lung cancer; patient-centered care; health care disparities; underserved populations; immigrants; supportive care ID COLORECTAL-CANCER; HEALTH-CARE; PATIENTS EXPERIENCES; PSYCHOSOCIAL CARE; UNITED-STATES; QUALITY; POPULATION; NAVIGATION; DIAGNOSIS; SURVIVORS AB BACKGROUND: The authors investigated the prevalence, determinants of, and disparities in any perceived unmet need for 8 supportive services (home nurse, support group, psychological services, social worker, physical/occupational rehabilitation, pain management, spiritual counseling, and smoking cessation) by race/ethnicity and nativity and how it is associated with perceived quality of care among US patients with lung cancer. METHODS: Data from a multiregional, multihealth system representative cohort of 4334 newly diagnosed patients were analyzed. Binomial logistic regression models adjusted for patient clustering. RESULTS: Patients with any perceived unmet need (9% overall) included 7% of white-US-born (USB), 9% of white-foreign-born (FB), 13% of black-USB, 8% of Latino-USB, 24% of Latino-FB, 4% of Asian/Pacific Islander (API)-USB, 14% of API-FB, and 11% of "other" patients (P<.001). Even after controlling for demographic and socioeconomic factors, health system and health care access, and need, black-USB, Latino-FB, and Asian-FB patients were more likely to perceive an unmet need than white-USB patients by 5.1, 10.9, and 5.6 percentage points, respectively (all P<.05). Being younger, female, never married, uninsured, a current smoker, or under surrogate care or having comorbidity, anxiety/depression, or a cost/insurance barrier to getting tests/treatments were associated with any unmet need. Patients with any unmet need were more likely to rate care as less-than-"excellent" by 13 percentage points than patients with no unmet need (P<.001). CONCLUSIONS: Significant disparities in unmet supportive service need by race/ethnicity and nativity highlight immigrants with lung cancer as being particularly underserved. Eliminating disparities in access to needed supportive services is essential for delivering patient-centered, equitable cancer care. (C) 2014 American Cancer Society. C1 [John, Dolly A.; Kawachi, Ichiro] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA. [Lathan, Christopher S.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Ayanian, John Z.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Ayanian, John Z.] Univ Michigan, Inst Healthcare Policy & Innovat, Ann Arbor, MI 48109 USA. [Ayanian, John Z.] Univ Michigan, Sch Med, Div Gen Med, Ann Arbor, MI USA. [Ayanian, John Z.] Univ Michigan, Sch Publ Hlth, Dept Hlth Management & Policy, Ann Arbor, MI 48109 USA. [Ayanian, John Z.] Univ Michigan, Gerald R Ford Sch Publ Policy, Ann Arbor, MI 48109 USA. RP John, DA (reprint author), Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, 665 Huntington Ave, Boston, MA 02115 USA. EM dollyjohn@gmail.com FU W.K. Kellogg Foundation - National Cancer Institute (NCI) [P50CA148596]; pilot grant from the Lung Cancer Disparities Center at Harvard University; NCI [U01CA093344, U01CA093324, U01CA093332, U01CA093348, U01CA093329, U01CA093339, U01CA093326]; Department of Veterans Affairs grant [CRS 02-164] FX Supported by the Kellogg Health Scholar Program funded by the W.K. Kellogg Foundation, grant P50CA148596 funded by the National Cancer Institute (NCI), and a pilot grant from the Lung Cancer Disparities Center at Harvard University. The Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium was supported by grants from the NCI to the Statistical Coordinating Center (Dana-Farber Cancer Institute [U01CA093344]) and the NCI-supported Primary Data Collection and Research Centers (Harvard Medical School/Northern California Cancer Center [U01CA093324], Dana-Farber Cancer Institute/Cancer Research Network [U01CA093332], RAND/University of California at Los Angeles [U01CA093348], University of Alabama at Birmingham [U01CA093329], University of Iowa [U01CA093339], and University of North Carolina [U01CA093326]) and by a Department of Veterans Affairs grant to the Durham VA Medical Center (CRS 02-164). These sources of support had no role in the conception and design of the current study, analysis or decision to publish. NR 56 TC 10 Z9 10 U1 7 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD OCT 15 PY 2014 VL 120 IS 20 BP 3178 EP 3191 DI 10.1002/cncr.28801 PG 14 WC Oncology SC Oncology GA AQ6GQ UT WOS:000342908800014 PM 24985538 ER PT J AU Veenstra, CM Epstein, AJ Liao, KJ Morris, AM Pollack, CE Armstrong, KA AF Veenstra, Christine M. Epstein, Andrew J. Liao, Kaijun Morris, Arden M. Pollack, Craig E. Armstrong, Katrina A. TI The Effect of Care Setting in the Delivery of High-Value Colon Cancer Care SO CANCER LA English DT Article DE colon cancer; academic medical centers; cost analysis; health policy; survival analysis; incremental cost-effectiveness ratio ID METASTATIC COLORECTAL-CANCER; ACADEMIC MEDICAL-CENTERS; PROSTATE-CANCER; HEPATIC RESECTION; SYSTEMIC THERAPY; CLINICAL-TRIALS; HEALTH-CARE; SURVIVAL; RECURRENCE; HOSPITALS AB BACKGROUND: The effect of care setting on value of colon cancer care is unknown. METHODS: A Surveillance, Epidemiology, and End Results (SEER)-Medicare cohort study of 6544 patients aged >= 66 years with stage IV colon cancer (based on the American Joint Committee on Cancer staging system) who were diagnosed between 1996 and 2005 was performed. All patients were followed through December 31, 2007. Using outpatient and carrier claims, patients were assigned to a treating hospital based on the hospital affiliation of the primary oncologist. Hospitals were classified academic or nonacademic using the SEER-Medicare National Cancer Institute Hospital File. RESULTS: Of the 6544 patients, 1605 (25%) received care from providers affiliated with academic medical centers. The unadjusted median cancer-specific survival was 16.0 months at academic medical centers versus 13.9 months at nonacademic medical centers (P<.001). After adjustment, treatment at academic hospitals remained significantly associated with a reduced risk of death from cancer (hazard ratio, 0.87; 95% confidence interval [95% CI], 0.82-0.93 [P<.001]). Adjusted mean 12-month Medicare spending was $8571 higher at academic medical centers (95% CI, $2340-$14,802; P=.007). The adjusted median cost was $1559 higher at academic medical centers; this difference was not found to be statistically significant (95% CI, -$5239 to $2122; P=.41). A small percentage of patients who received very expensive care skewed the difference in mean cost; the only statistically significant difference in adjusted costs in quantile regressions was at the 99.9th percentile of costs (P<.001). CONCLUSIONS: Among Medicare beneficiaries with stage IV colon cancer, treatment by a provider affiliated with an academic medical center was associated with a 2 month improvement in overall survival. Except for patients in the 99.9th percentile of the cost distribution, costs at academic medical centers were not found to be significantly different from those at nonacademic medical centers. (C) 2014 American Cancer Society. C1 [Veenstra, Christine M.] Univ Michigan, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA. [Epstein, Andrew J.] Univ Penn, Perelman Sch Med, Dept Internal Med, Philadelphia, PA 19104 USA. [Liao, Kaijun] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Morris, Arden M.] Univ Michigan, Dept Surg, Ctr Healthcare Outcomes & Policy, Ann Arbor, MI 48109 USA. [Pollack, Craig E.] Johns Hopkins Univ, Sch Med, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Armstrong, Katrina A.] Massachusetts Gen Hosp, Dept Internal Med, Boston, MA 02114 USA. RP Veenstra, CM (reprint author), Univ Michigan, Dept Internal Med, Div Hematol Oncol, North Ingalls Bldg,3A22,300 North Ingalls, Ann Arbor, MI 48109 USA. EM cveenstr@med.umich.edu FU National Cancer Institute at the National Institutes of Health [T32 CA009615-21] FX Supported by the National Cancer Institute at the National Institutes of Health (grant T32 CA009615-21 to Dr. Veenstra). NR 36 TC 4 Z9 4 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD OCT 15 PY 2014 VL 120 IS 20 BP 3237 EP 3244 DI 10.1002/cncr.28874 PG 8 WC Oncology SC Oncology GA AQ6GQ UT WOS:000342908800020 PM 24954628 ER PT J AU Boyle, CA Perrin, JM Moyer, VA AF Boyle, Coleen A. Perrin, James M. Moyer, Virginia A. TI Use of Clinical Preventive Services in Infants, Children, and Adolescents SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material C1 [Boyle, Coleen A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Perrin, James M.] MassGen Hosp Children, Div Gen Pediat, Ctr Child & Adolescent Hlth Res & Policy, Boston, MA USA. [Perrin, James M.] Harvard Univ, Sch Med, Boston, MA USA. [Moyer, Virginia A.] Amer Board Pediat Inc, Chapel Hill, NC USA. RP Boyle, CA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd, Atlanta, GA 30333 USA. FU Intramural CDC HHS [CC999999] NR 7 TC 3 Z9 3 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 15 PY 2014 VL 312 IS 15 BP 1509 EP 1510 DI 10.1001/jama.2014.12890 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AQ7HL UT WOS:000342983200010 PM 25208100 ER PT J AU Neuman, MD Wirtalla, C Werner, RM AF Neuman, Mark D. Wirtalla, Christopher Werner, Rachel M. TI Association Between Skilled Nursing Facility Quality Indicators and Hospital Readmissions SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID POST-ACUTE CARE; OF-CARE; RACIAL DISPARITIES; MEDICAID PAYMENT; HOME RESIDENTS; FOR-PROFIT; DEFICIENCIES; REHOSPITALIZATION; PROGRAM; COST AB IMPORTANCE Hospital readmissions are common, costly, and potentially preventable. Little is known about the association between available skilled nursing facility (SNF) performance measures and the risk of hospital readmission. OBJECTIVE To measure the association between SNF performance measures and hospital readmissions among Medicare beneficiaries receiving postacute care at SNFs in the United States. DESIGN AND PARTICIPANTS Using national Medicare data on fee-for-service Medicare beneficiaries discharged to a SNF after an acute care hospitalization between September 1, 2009, and August 31, 2010, we examined the association between SNF performance on publicly available metrics (SNF staffing intensity, health deficiencies identified through site inspections, and the percentages of SNF patients with delirium, moderate to severe pain, and new or worsening pressure ulcers) and the risk of readmission or death 30 days after discharge to a SNF. Adjusted analyses controlled for patient case mix, SNF facility factors, and the discharging hospital. MAIN OUTCOMES AND MEASURES Readmission to an acute care hospital or death within 30 days of the index hospital discharge. RESULTS Of 1 530 824 patients discharged, 357 752 (23.3%; 99% CI, 23.3%-23.5%) were readmitted or died within 30 days; 72 472 died within 30 days (4.7%; 99% CI, 4.7%-4.8%), and 321 709 were readmitted (21.0%; 99% CI, 20.9%-21.1%). The unadjusted risk of readmission or death was lower at SNFs with better staffing ratings and better facility inspection ratings. [GRAPHICS] Adjustment for patient factors, SNF facility factors, and the discharging hospital attenuated these associations; we observed small differences in the adjusted risk of readmission or death according to SNF facility inspection ratings. Other measures did not predict clinically meaningful differences in the adjusted risk of readmission or death. CONCLUSIONS AND RELEVANCE Among fee-for-service Medicare beneficiaries discharged to a SNF after an acute care hospitalization, available performance measures were not consistently associated with differences in the adjusted risk of readmission or death. Copyright 2014 American Medical Association. All rights reserved. C1 [Neuman, Mark D.] Univ Penn, Dept Anesthesiol & Crit Care, Perelman Sch Med, Philadelphia, PA 19104 USA. [Neuman, Mark D.; Werner, Rachel M.] Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA. [Wirtalla, Christopher; Werner, Rachel M.] Univ Penn, Div Gen Internal Med, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA. [Werner, Rachel M.] Philadelphia VA Med Ctr, Ctr Hlth Equity Res & Promot, Philadelphia, PA USA. RP Neuman, MD (reprint author), Univ Penn, Dept Anesthesiol & Crit Care, Perelman Sch Med, 423 Guardian Dr,1119A Blockley Hall, Philadelphia, PA 19104 USA. EM neumanm@mail.med.upenn.edu FU National Institute on Aging [K08AG043548, R01 AG034182] FX This work was supported by grants from the National Institute on Aging (grant K08AG043548 to Dr Neuman; grant R01 AG034182 to Dr Werner). NR 36 TC 18 Z9 18 U1 3 U2 13 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 15 PY 2014 VL 312 IS 15 BP 1542 EP 1551 DI 10.1001/jama.2014.13513 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AQ7HL UT WOS:000342983200018 PM 25321909 ER PT J AU Rogers, T Milkman, KL Volpp, KG AF Rogers, Todd Milkman, Katherine L. Volpp, Kevin G. TI Commitment Devices to Improve Unhealthy Behaviors Reply SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 [Rogers, Todd] Harvard Univ, Harvard Kennedy Sch, Boston, MA 02115 USA. [Milkman, Katherine L.] Univ Penn, Wharton Sch, Philadelphia, PA 19104 USA. [Volpp, Kevin G.] UPENN Ctr Hlth Incent & Behav Econ, Philadelphia VA Med Ctr, Philadelphia, PA USA. RP Volpp, KG (reprint author), Univ Penn, Philadelphia VA Med Ctr, Perelman Sch Med, 423 Guardian Dr, Philadelphia, PA 19104 USA. EM volpp70@exchange.upenn.edu NR 1 TC 0 Z9 0 U1 1 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 15 PY 2014 VL 312 IS 15 BP 1592 EP 1593 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AQ7HL UT WOS:000342983200031 PM 25321920 ER PT J AU Bera, A Das, F Ghosh-Choudhury, N Kasinath, BS Abboud, HE Choudhury, GG AF Bera, Amit Das, Falguni Ghosh-Choudhury, Nandini Kasinath, Balakuntalam S. Abboud, Hanna E. Choudhury, Goutam Ghosh TI microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKK beta-mTORC1 axis to regulate renal cancer cell invasion SO EXPERIMENTAL CELL RESEARCH LA English DT Article DE Renal carcinoma; miR-21; Akt kinase; mTOR ID NF-KAPPA-B; TUMOR-SUPPRESSOR PDCD4; INITIATION-FACTOR 4A; KIDNEY CANCER; MAMMALIAN TARGET; BREAST-CANCER; TRANSFORMATION SUPPRESSOR; HEPATOCELLULAR-CARCINOMA; PROGRAMMED CELL-DEATH-4; MICRORNA EXPRESSION AB Renal cancer metastasis may result from oncogenic forces that contribute to the primary tumor. We have recently identified microRNA-21 as an oncogenic driver of renal cancer cells. The mechanism by which miR-21 controls renal cancer cell invasion is poorly understood. We show that miR-21 directly downregulates the proapoptotic protein PDCD4 to increase migration and invasion of ACHN and 786-O renal cancer cells as a result of phosphorylation/activation of Akt and IKK beta, which activate NF kappa B-dependent transcription. Constitutively active (CA) Akt or CA IKK beta blocks PDCD4-mediated inhibition and restores renal cancer cell migration and invasion. PDCD4 inhibits mTORC1 activity, which was reversed by CA IKK beta. Moreover, CA mTORC1 restores cell migration and invasion inhibited by PDCD4 and dominant negative IKK beta. Moreover, PDCD4 negatively regulates mTORC2-dependent Akt phosphorylation upstream of this cascade. We show that PDCD4 forms a complex with rictor, an exclusive component of mTORC2, and that this complex formation is reduced in renal cancer cells due to increased miR-21 expression resulting in enhanced phospholylation of Akt. Thus our results identify a previously unrecognized signaling node where high miR-21 levels reduce rictor PDCD4 interaction to increase phosphorylation of Akt and contribute to metastatic fitness of renal cancer cells. (C) 2014 Elsevier Inc. All rights reserved. C1 [Ghosh-Choudhury, Nandini; Kasinath, Balakuntalam S.; Abboud, Hanna E.; Choudhury, Goutam Ghosh] South Texas Vet Hlth Care Syst, Vet Adm Res Serv, San Antonio, TX USA. [Ghosh-Choudhury, Nandini] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Bera, Amit; Das, Falguni; Kasinath, Balakuntalam S.; Abboud, Hanna E.; Choudhury, Goutam Ghosh] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Choudhury, Goutam Ghosh] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX USA. RP Choudhury, GG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. EM choudhuryg@uthscsa.edu FU VA Research Service Merit Review [5101BX000926, 5101BX000150]; NIH [RO1 DK50190]; VA Senior Research Career Scientist Award; VA Research Service grants; Cancer Therapy and Research Center at San Antonio FX The results described in this manuscript are the work supported by VA Research Service Merit Review 5101BX000926 and NIH RO1 DK50190 grants to GGC. GGC is a recipient of VA Senior Research Career Scientist Award. BSI and HEA are supported by NIH and VA Research Service grants (BSI and HEA). NGC is supported by VA Research Service Merit Review 5101BX000150 grant and a pilot grant from Cancer Therapy and Research Center at San Antonio. NR 129 TC 16 Z9 20 U1 2 U2 5 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4827 EI 1090-2422 J9 EXP CELL RES JI Exp. Cell Res. PD OCT 15 PY 2014 VL 328 IS 1 BP 99 EP 117 DI 10.1016/j.yexcr.2014.06.022 PG 19 WC Oncology; Cell Biology SC Oncology; Cell Biology GA AQ1KK UT WOS:000342540100008 PM 25016284 ER PT J AU Hsieh, CL Niemi, EC Wang, SH Lee, CC Bingham, D Zhang, JS Cozen, ML Charo, I Huang, EJ Liu, JL Nakamura, MC AF Hsieh, Christine L. Niemi, Erene C. Wang, Sarah H. Lee, Chih Cheng Bingham, Deborah Zhang, Jiasheng Cozen, Myrna L. Charo, Israel Huang, Eric J. Liu, Jialing Nakamura, Mary C. TI CCR2 Deficiency Impairs Macrophage Infiltration and Improves Cognitive Function after Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE brain injury; CCR2; chemotaxis; inflammation; macrophage ID CHEMOKINE RECEPTOR CCR2; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; SPINAL-CORD-INJURY; NEUROPATHIC PAIN; MOUSE MODEL; HIPPOCAMPAL NEUROGENESIS; MONOCYTE RECRUITMENT; CRANIAL IRRADIATION AB Traumatic brain injury (TBI) provokes inflammatory responses, including a dramatic rise in brain macrophages in the area of injury. The pathway(s) responsible for macrophage infiltration of the traumatically injured brain and the effects of macrophages on functional outcomes are not well understood. C-C-chemokine receptor 2 (CCR2) is known for directing monocytes to inflamed tissues. To assess the role of macrophages and CCR2 in TBI, we determined outcomes in CCR2-deficient (Ccr2(-/-)) mice in a controlled cortical impact model. We quantified brain myeloid cell numbers post-TBI by flow cytometry and found that Ccr2(-/-) mice had greatly reduced macrophage numbers (similar to 80-90% reduction) early post-TBI, compared with wild-type mice. Motor, locomotor, and cognitive outcomes were assessed. Lack of Ccr2 improved locomotor activity with less hyperactivity in open field testing, but did not affect anxiety levels or motor coordination on the rotarod three weeks after TBI. Importantly, Ccr2(-/-) mice demonstrated greater spatial learning and memory, compared with wildtype mice eight weeks after TBI. Although there was no difference in the volume of tissue loss, Ccr2(-/-) mice had significantly increased neuronal density in the CA1-CA3 regions of the hippocampus after TBI, compared with wild-type mice. These data demonstrate that Ccr2 directs the majority of macrophage homing to the brain early after TBI and indicates that Ccr2 may facilitate harmful responses. Lack of Ccr2 improves functional recovery and neuronal survival. These results suggest that therapeutic blockade of CCR2-dependent responses may improve outcomes following TBI. C1 [Hsieh, Christine L.; Niemi, Erene C.; Wang, Sarah H.; Nakamura, Mary C.] San Francisco VA Med Ctr, Immunol Sect, San Francisco, CA 94121 USA. [Lee, Chih Cheng; Bingham, Deborah; Liu, Jialing] San Francisco VA Med Ctr, Dept Neurol Surg, San Francisco, CA 94121 USA. [Zhang, Jiasheng; Huang, Eric J.] San Francisco VA Med Ctr, Pathol Serv, San Francisco, CA 94121 USA. [Cozen, Myrna L.] San Francisco VA Med Ctr, Ctr Liver, San Francisco, CA 94121 USA. [Hsieh, Christine L.; Niemi, Erene C.; Wang, Sarah H.; Cozen, Myrna L.; Charo, Israel; Nakamura, Mary C.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Lee, Chih Cheng; Bingham, Deborah; Liu, Jialing] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA. [Zhang, Jiasheng; Huang, Eric J.] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA. [Charo, Israel] Gladstone Inst Cardiovasc Dis, San Francisco, CA USA. RP Hsieh, CL (reprint author), San Francisco VA Med Ctr, Immunol Sect, 4150 Clement St,111-R Bldg 2,Room 500, San Francisco, CA 94121 USA. EM Christine.Hsieh@ucsf.edu RI Liu, Jialing/A-8627-2012; OI Liu, Jialing/0000-0003-4420-4382; Huang, Eric/0000-0002-5381-3801 FU Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development Career Development Award-2; Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development; Russell/Engelman Center for Arthritis Research FX The authors thank Ruby Gribi of the San Francisco VA Flow Cytometry core, Ivy Hsieh and Sherry Kamiya of the San Francisco VA Cell Imaging core for their dedication and contributions to this project. This material is based upon work supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development Career Development Award-2 to CLH. MCN is supported in part by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development Merit Award and by the Russell/Engelman Center for Arthritis Research. With tremendous gratitude, we acknowledge Dr. William E. Seaman for helpful discussions and an insightful review of this manuscript. NR 80 TC 23 Z9 24 U1 1 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT 15 PY 2014 VL 31 IS 20 BP 1677 EP 1688 DI 10.1089/neu.2013.3252 PG 12 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AP8BF UT WOS:000342302200001 PM 24806994 ER PT J AU Calabrese, JR Fava, M Garibaldi, G Grunze, H Krystal, AD Laughren, T Macfadden, W Marin, R Nierenberg, AA Tohen, M AF Calabrese, Joseph R. Fava, Maurizio Garibaldi, George Grunze, Heinz Krystal, Andrew D. Laughren, Thomas Macfadden, Wayne Marin, Robert Nierenberg, Andrew A. Tohen, Mauricio TI Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Review DE Amotivation; Apathy; Motivational deficits; Mood disorders ID MAJOR-DEPRESSIVE DISORDER; SEROTONIN REUPTAKE INHIBITORS; APATHY EVALUATION SCALE; PARKINSONS-DISEASE; TASK-FORCE; ANTIDEPRESSANT TREATMENT; PSYCHOMETRIC PROPERTIES; QUETIAPINE MONOTHERAPY; DIAGNOSTIC-CRITERIA; INCENTIVE SALIENCE AB Background: There is growing research interest in studying motivational deficits in different neuropsychiatric disorders because these symptoms appear to be more common than originally reported and negatively impact long-term functional outcomes. However, there is considerable ambiguity in the terminology used to describe motivational deficits in the scientific literature. For the purposes of this manuscript, the term "amotivation" will be utilised in the context of mood disorders, since this is considered a more inclusive/appropriate term for this patient population. Other challenges impacting the study of amotivation in mood disorders, include: appropriate patient population selection; managing or controlling for potential confounding factors; the lack of goldstandard diagnostic criteria and assessment scales; and determination of the most appropriate study duration. Methods: This paper summarises the search for a consensus by a group of experts in the optimal approach to studying amotivation in mood disorders. Results: The consensus of this group is that amotivation in mood disorders is a legitimate therapeutic target, given the magnitude of the associated unmet needs, and that proof-of-concept studies should be conducted in order to facilitate subsequent larger investigations. The focus of this manuscript is to consider the study of amotivation, as a residual symptom of major depressive disorder (MDD) or bipolar depression (BD), following adequate treatment with a typical antidepressant or mood stabiliser/ antipsychotic, respectively. Discussion: There is a paucity of data studying amotivation in mood disorders. This manuscript provides general guidance on the most appropriate study design(s) and methodology to assess potential therapeutic options for the management of residual amotivation in mood disorders. (C) 2014 Elsevier By, All rights reserved. C1 [Calabrese, Joseph R.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Sch Med, Bipolar Disorders Res Ctr, Cleveland, OH 44106 USA. [Fava, Maurizio; Nierenberg, Andrew A.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Garibaldi, George; Macfadden, Wayne] F Hoffman La Roche AG, Basel, Switzerland. [Grunze, Heinz] Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. [Krystal, Andrew D.] Duke Univ, Sch Med, Durham, NC USA. [Laughren, Thomas] Laughren Psychopharm Consulting, Rockville, MD USA. [Marin, Robert] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Tohen, Mauricio] Univ New Mexico, Albuquerque, NM 87131 USA. RP Calabrese, JR (reprint author), Case Western Reserve Univ, Univ Hosp Case Med Ctr, Sch Med, Bipolar Disorders Res Ctr, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA. EM Joseph.Calabrese@UHhospitals.org OI Grunze, Heinz/0000-0003-4712-8979 FU Roche FX The authors would like to thank Julie Wilson, Paul Gandhi, Martin Jones and Rachel Danks at Bridge Medical for their assistance with the preparation of this manuscript. Editorial assistance was funded by Roche. NR 71 TC 9 Z9 9 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 EI 1573-2517 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD OCT 15 PY 2014 VL 168 BP 439 EP 451 DI 10.1016/j.jad.2014.06.056 PG 13 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA AO6SZ UT WOS:000341483100058 PM 25113957 ER PT J AU Thunemann, M Schmidt, K de Wit, C Han, XX Jain, RK Fukumura, D Feil, R AF Thunemann, Martin Schmidt, Kjestine de Wit, Cor Han, Xiaoxing Jain, Rakesh K. Fukumura, Dai Feil, Robert TI Correlative intravital imaging of cGMP signals and vasodilation in mice SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE biosensor; cremaster; cyclic GMP; dorsal skinfold chamber; fluorescence resonance energy transfer; intravital imaging; microcirculation; multiphoton microscopy ID RESONANCE ENERGY-TRANSFER; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; DEPENDENT PROTEIN-KINASES; SMOOTH-MUSCLE-CELLS; IN-VIVO; TRANSGENIC MICE; MULTIPHOTON MICROSCOPY; FLUORESCENCE LIFETIME; 2-PHOTON EXCITATION; CARDIAC MYOCYTES AB Cyclic guanosine monophosphate (cGMP) is an important signaling molecule and drug target in the cardiovascular system. It is well known that stimulation of the vascular nitric oxide (NO)-cGMP pathway results in vasodilation. However, the spatiotemporal dynamics of cGMP signals themselves and the cGMP concentrations within specific cardiovascular cell types in health, disease, and during pharmacotherapy with cG MP-elevating drugs are largely unknown. To facilitate the analysis of cGMP signaling in vivo, we have generated transgenic mice that express fluorescence resonance energy transfer (FRET)-based cGMP sensor proteins. Here, we describe two models of intravital FRET/cGMP imaging in the vasculature of cGMP sensor mice: (1) epifluorescence-based ratio imaging in resistance-type vessels of the cremaster muscle and (2) ratio imaging by multiphoton microscopy within the walls of subcutaneous blood vessels accessed through a dorsal skinfold chamber. Both methods allow simultaneous monitoring of NO-induced cGMP transients and vasodilation in living mice. Detailed protocols of all steps necessary to perform and evaluate intravital imaging experiments of the vasculature of anesthetized mice including surgery, imaging, and data evaluation are provided. An image segmentation approach is described to estimate FRET/cGMP changes within moving structures such as the vessel wall during vasodilation. The methods presented herein should be useful to visualize cGMP or other biochemical signals that are detectable with FRET-based biosensors, such as cyclic adenosine monophosphate or Ca2+, and to correlate them with respective vascular responses. With further refinement and combination of transgenic mouse models and intravital imaging technologies, we envision an exciting future, in which we are able to "watch" biochemistry, (patho-)physiology, and pharmacotherapy in the context of a living mammalian organism. C1 [Thunemann, Martin; Feil, Robert] Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany. [Schmidt, Kjestine; de Wit, Cor] Med Univ Lubeck, Inst Physiol, D-23538 Lubeck, Germany. [Han, Xiaoxing; Jain, Rakesh K.; Fukumura, Dai] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA. [Han, Xiaoxing; Jain, Rakesh K.; Fukumura, Dai] Harvard Univ, Sch Med, Boston, MA USA. RP Feil, R (reprint author), Univ Tubingen, Interfak Inst Biochem, Hoppe Seyler Str 4, D-72076 Tubingen, Germany. EM robert.feil@uni-tuebingen.de RI de Wit, Cor/A-5560-2009; Feil, Robert/B-8918-2014 OI de Wit, Cor/0000-0003-4621-0399; Feil, Robert/0000-0002-7335-4841 FU Open Access Publishing Fund of Tubingen University; Deutsche Forschungsgemeinschaft; US Department of Defense Breast Cancer Research Innovator Award [W81XWH-10-1-0016]; US National Cancer Institute [P01-CA080124, R01-CA096915] FX We thank Barbara Birk and Rita Meurer for excellent technical assistance, Julia Kahn for help with DSC implantation, and Lai Wen for providing R26-CAG-cGi500(L2) mice. We want to acknowledge Ralf Jansen for providing imaging equipment, as well as FEI Munich and Visitron for support during establishment of cremaster IVM. The authors would like to thank Lai Wen and Markus Milde for providing unpublished data and reading the manuscript, as well as all members of the Feil laboratory for critical discussion. This work was supported by Open Access Publishing Fund of Tubingen University and the Deutsche Forschungsgemeinschaft (Robert Feil), the US Department of Defense Breast Cancer Research Innovator Award W81XWH-10-1-0016 (Rakesh K. Jam) and US National Cancer Institute grants P01-CA080124 (Rakesh K. Jam and Dai Fukumura) and R01-CA096915 (Dai Fukumura). NR 79 TC 2 Z9 3 U1 0 U2 8 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD OCT 14 PY 2014 VL 5 AR 394 DI 10.3389/fphys.2014.00394 PG 15 WC Physiology SC Physiology GA AX7XG UT WOS:000347124500002 PM 25352809 ER PT J AU Skardelly, M Gaber, K Burdack, S Scheidt, F Schuhmann, MU Hilbig, H Meixensberger, J Boltze, J AF Skardelly, Marco Gaber, Khaled Burdack, Swen Scheidt, Franziska Schuhmann, Martin U. Hilbig, Heidegard Meixensberger, Juergen Boltze, Johannes TI Transient but not permanent benefit of neuronal progenitor cell therapy after traumatic brain injury: potential causes and translational consequences SO FRONTIERS IN CELLULAR NEUROSCIENCE LA English DT Article DE neural progenitor cells; cell therapy; TBI; long-term functional outcome; translational research ID NEURAL STEM-CELLS; IMMUNE PRIVILEGE; NITRIC-OXIDE; TRANSPLANTATION; RATS; NEUROGENESIS; RECOVERY; BARRIER; STROKE; CNS AB Background: Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between local and systemic transplantation is missing so far. Objectives: This study investigated the long-term (12 week) impact of human fetal neuronal progenitor cell (hNPC) transplantation 24 h after severe TB I in rats. Methods: Cells were either transplanted stereotactically (1 x 105) into the putamen or systemically (5 x 105) via the tail vein. Control animals received intravenous transplantation of vehicle solution. Results: An overall functional benefit was observed after systemic, but not local hNPC transplantation by area under the curve analysis (p < 0.01). Surprisingly, this effect vanished during later stages after TBI with all groups exhibiting comparable functional outcomes 84 days after TBI. Investigation of cell-mediated inflammatory processes revealed increasing microglial activation and macrophage presence during these stages, which was statistically significant after systemic cell administration (p < 0.05). Intracerebral hNPC transplantation slightly diminished astrogliosis in perilesional areas (p < 0.01), but did not translate into a permanent functional benefit. No significant effects on angiogenesis were observed among the groups. Conclusion: Our results suggest the careful long-term assessment of cell therapies for TBI, as well as to identify potential long-term detrimental effects of such therapies before moving on to clinical trials. Moreover, immunosuppressive protocols, though widely used, should be rigorously assessed for their applicability in the respective setup. C1 [Skardelly, Marco; Gaber, Khaled; Burdack, Swen; Scheidt, Franziska; Schuhmann, Martin U.; Meixensberger, Juergen] Univ Leipzig, Dept Neurosurg, D-04109 Leipzig, Germany. [Hilbig, Heidegard] Univ Leipzig, Inst Anat, D-04109 Leipzig, Germany. [Boltze, Johannes] Univ Leipzig, Fraunhofer Inst Cell Therapy & Immunol, D-04109 Leipzig, Germany. [Boltze, Johannes] Univ Leipzig, Translat Ctr Regenerat Med, D-04109 Leipzig, Germany. [Boltze, Johannes] Massachusetts Gen Hosp, Stroke & Neurovasc Regulat Lab, Charlestown, MA USA. [Boltze, Johannes] Harvard Univ, Sch Med, Charlestown, MA USA. RP Skardelly, M (reprint author), Univ Tubingen, Dept Neurosurg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany. EM marco.skardelly@med.uni-tuebingen.de FU funds of the Free State of Saxony distributed by the University of Leipzig [1-56]; Deutsche Forschungsgemeinschaft; Open Access Publishing Fund of Tuebingen University FX The authors would like to thank Ingo Roeder for statistical support and Jochen Neuhaus for technical support. This work was supported by funds of the Free State of Saxony distributed by the University of Leipzig (Formel-1-program, 1-56). The authors acknowledge support from Deutsche Forschungsgemeinschaft and Open Access Publishing Fund of Tuebingen University. NR 44 TC 2 Z9 2 U1 1 U2 5 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5102 J9 FRONT CELL NEUROSCI JI Front. Cell. Neurosci. PD OCT 14 PY 2014 VL 8 AR UNSP 318 DI 10.3389/fncel.2014.00318 PG 13 WC Neurosciences SC Neurosciences & Neurology GA AS8WF UT WOS:000344525200003 PM 25352780 ER PT J AU Narayanaswami, P Weiss, M Selcen, D David, W Raynor, E Carter, G Wicklund, M Barohn, RJ Ensrud, E Griggs, RC Gronseth, G Amato, AA AF Narayanaswami, Pushpa Weiss, Michael Selcen, Duygu David, William Raynor, Elizabeth Carter, Gregory Wicklund, Matthew Barohn, Richard J. Ensrud, Erik Griggs, Robert C. Gronseth, Gary Amato, Anthony A. TI Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine SO NEUROLOGY LA English DT Article ID REDUCING BODY MYOPATHY; MUSCULAR-DYSTROPHY; SKELETAL MYOPATHY; DESMIN GENE; PHENOTYPIC SPECTRUM; FHL1 MUTATIONS; DYSTROGLYCAN; EPIDEMIOLOGY; POPULATION; PREVALENCE AB Objective: To review the current evidence and make practice recommendations regarding the diagnosis and treatment of limb-girdle muscular dystrophies (LGMDs). Methods: Systematic review and practice recommendation development using the American Academy of Neurology guideline development process. Results: Most LGMDs are rare, with estimated prevalences ranging from 0.07 per 100,000 to 0.43 per 100,000. The frequency of some muscular dystrophies varies based on the ethnic background of the population studied. Some LGMD subtypes have distinguishing features, including pattern of muscle involvement, cardiac abnormalities, extramuscular involvement, and muscle biopsy findings. The few published therapeutic trials were not designed to establish clinical efficacy of any treatment. Principal recommendations: For patients with suspected muscular dystrophy, clinicians should use a clinical approach to guide genetic diagnosis based on clinical phenotype, inheritance pattern, and associated manifestations (Level B). Clinicians should refer newly diagnosed patients with an LGMD subtype and high risk of cardiac complications for cardiology evaluation even if they are asymptomatic from a cardiac standpoint (Level B). In patients with LGMD with a known high risk of respiratory failure, clinicians should obtain periodic pulmonary function testing (Level B). Clinicians should refer patients with muscular dystrophy to a clinic that has access to multiple specialties designed specifically to care for patients with neuromuscular disorders (Level B). Clinicians should not offer patients with LGMD gene therapy, myoblast transplantation, neutralizing antibody to myostatin, or growth hormone outside of a research study designed to determine efficacy and safety of the treatment (Level R). Detailed results and recommendations are available on the Neurology (R) Web site at Neurology.org. C1 [Narayanaswami, Pushpa; Raynor, Elizabeth] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neurol, Boston, MA 02215 USA. [Weiss, Michael] Univ Washington, Med Ctr, Dept Neurol, Seattle, WA 98195 USA. [Selcen, Duygu] Mayo Clin, Dept Neurol, Rochester, MN USA. [David, William] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Carter, Gregory] St Lukes Rehabil Inst, Spokane, WA USA. [Wicklund, Matthew] Penn State Hershey Med Ctr, Dept Neurol, Hershey, PA USA. [Barohn, Richard J.; Gronseth, Gary] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS USA. [Ensrud, Erik] Boston VA Med Ctr, Neuromuscular Ctr, Boston, MA USA. [Griggs, Robert C.] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14627 USA. [Ensrud, Erik; Amato, Anthony A.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol, Boston, MA 02115 USA. RP Narayanaswami, P (reprint author), Amer Acad Neurol, Washington, DC 20002 USA. EM guidelines@aan.com FU Centers for Disease Control and Prevention [DD10-1012]; American Academy of Neurology FX Funding for this publication was made possible (in part) by grant DD10-1012 from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The remaining funding was provided by the American Academy of Neurology. NR 40 TC 22 Z9 24 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD OCT 14 PY 2014 VL 83 IS 16 BP 1453 EP 1463 PG 11 WC Clinical Neurology SC Neurosciences & Neurology GA AT3RD UT WOS:000344850500015 PM 25313375 ER PT J AU Prat, A Lluch, A Albanell, J Barry, WT Fan, C Chacon, JI Parker, JS Calvo, L Plazaola, A Arcusa, A Segui-Palmer, MA Burgues, O Ribelles, N Rodriguez-Lescure, A Guerrero, A Ruiz-Borrego, M Munarriz, B Lopez, JA Adamo, B Cheang, MCU Li, Y Hu, Z Gulley, ML Vidal, MJ Pitcher, BN Liu, MC Citron, ML Ellis, MJ Mardis, E Vickery, T Hudis, CA Winer, EP Carey, LA Caballero, R Carrasco, E Martin, M Perou, CM Alba, E AF Prat, A. Lluch, A. Albanell, J. Barry, W. T. Fan, C. Chacon, J. I. Parker, J. S. Calvo, L. Plazaola, A. Arcusa, A. Segui-Palmer, M. A. Burgues, O. Ribelles, N. Rodriguez-Lescure, A. Guerrero, A. Ruiz-Borrego, M. Munarriz, B. Lopez, J. A. Adamo, B. Cheang, M. C. U. Li, Y. Hu, Z. Gulley, M. L. Vidal, M. J. Pitcher, B. N. Liu, M. C. Citron, M. L. Ellis, M. J. Mardis, E. Vickery, T. Hudis, C. A. Winer, E. P. Carey, L. A. Caballero, R. Carrasco, E. Martin, M. Perou, C. M. Alba, E. TI Predicting response and survival in chemotherapy-treated triple-negative breast cancer SO BRITISH JOURNAL OF CANCER LA English DT Article DE breast cancer; genomics; subtypes; intrinsic; basal like; chemotherapy; neoadjuvant ID BASAL-LIKE; MOLECULAR CHARACTERIZATION; INTRINSIC SUBTYPES; RANDOMIZED-TRIAL; PROGNOSIS; CYCLOPHOSPHAMIDE; FLUOROURACIL; PACLITAXEL; CLASSIFICATION; SENSITIVITY AB Background: In this study, we evaluated the ability of gene expression profiles to predict chemotherapy response and survival in triple-negative breast cancer (TNBC). Methods: Gene expression and clinical-pathological data were evaluated in five independent cohorts, including three randomised clinical trials for a total of 1055 patients with TNBC, basal-like disease (BLBC) or both. Previously defined intrinsic molecular subtype and a proliferation signature were determined and tested. Each signature was tested using multivariable logistic regression models (for pCR (pathological complete response)) and Cox models (for survival). Within TNBC, interactions between each signature and the basal-like subtype (vs other subtypes) for predicting either pCR or survival were investigated. Results: Within TNBC, all intrinsic subtypes were identified but BLBC predominated (55-81%). Significant associations between genomic signatures and response and survival after chemotherapy were only identified within BLBC and not within TNBC as a whole. In particular, high expression of a previously identified proliferation signature, or low expression of the luminal A signature, was found independently associated with pCR and improved survival following chemotherapy across different cohorts. Significant interaction tests were only obtained between each signature and the BLBC subtype for prediction of chemotherapy response or survival. Conclusions: The proliferation signature predicts response and improved survival after chemotherapy, but only within BLBC. This highlights the clinical implications of TNBC heterogeneity, and suggests that future clinical trials focused on this phenotypic subtype should consider stratifying patients as having BLBC or not. C1 [Prat, A.; Vidal, M. J.] Vall dHebron Inst Oncol, Translat Genom Grp, Barcelona 08035, Spain. [Prat, A.] Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain. [Lluch, A.; Burgues, O.] Hosp Clin Univ Valencia, Dept Med Oncol, Valencia 46010, Spain. [Lluch, A.] Hosp Clin Univ Valencia, Dept Pathol, Valencia 46010, Spain. [Albanell, J.] Hosp Mar, IMIM, Dept Med Oncol, Barcelona 08003, Spain. [Barry, W. T.] Univ Pompeu Fabra, Dept Med Oncol, Barcelona 08002, Spain. [Barry, W. T.] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02215 USA. [Fan, C.; Parker, J. S.; Cheang, M. C. U.; Li, Y.; Hu, Z.; Gulley, M. L.; Carey, L. A.; Perou, C. M.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27519 USA. [Chacon, J. I.] Hosp Virgen de la Salud, Dept Med Oncol, Toledo 45004, OH, Spain. [Parker, J. S.; Perou, C. M.] Univ N Carolina, Dept Genet, Chapel Hill, NC 27519 USA. [Calvo, L.] Complexo Hosp Univ A Coruna, Dept Med Oncol, La Coruna 15002, Spain. [Plazaola, A.] Onkologikoa, Dept Med Oncol, San Sebastian 20014, Spain. [Arcusa, A.] Consorci Sanitari Terrassa, Dept Med Oncol, Barcelona 08225, Spain. [Segui-Palmer, M. A.] Corp Sanitaria Parc Tauli, Dept Med Oncol, Sabadell 08208, Spain. [Ribelles, N.; Alba, E.] Hosp Univ Virgen de la Victoria, Dept Med Oncol, Malaga 29010, Spain. [Ribelles, N.; Alba, E.] Hosp Univ Virgen de la Victoria, Dept Pathol, Malaga 29010, Spain. [Rodriguez-Lescure, A.] Hosp Gen de Elche, Dept Med Oncol, Alicante 03203, Spain. [Guerrero, A.] Inst Valenciano Oncol, Dept Med Oncol, Valencia 46009, Spain. [Ruiz-Borrego, M.] Hosp Univ Virgen del Roci, Dept Med Oncol, Seville 41013, Spain. [Munarriz, B.] Hosp Univ La Fe, Dept Med Oncol, Valencia 46026, Spain. [Lopez, J. A.] Hosp San Camilo, Dept Med Oncol, Madrid 28006, Spain. [Pitcher, B. N.] Duke Univ, Alliance Stat & Data Ctr, Durham, NC 27708 USA. [Liu, M. C.] Mayo Clin, Dept Oncol, Rochester, MN 55905 USA. [Citron, M. L.] ProHEALTH Care Associates LLP, Lake Success, NY 11803 USA. [Ellis, M. J.; Mardis, E.; Vickery, T.] Washington Univ, Dept Oncol, St Louis, MO 63130 USA. [Hudis, C. A.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA. [Winer, E. P.] Dana Farber Canc Inst, Boston, MA 02215 USA. [Caballero, R.; Carrasco, E.] GEICAM Spanish Breast Canc Res Grp, Madrid 28700, Spain. [Martin, M.] Univ Complutense, Fac Med, Hosp Univ Gregorio Maranon, Dept Med Oncol,Inst Invest Sanitaria, Madrid 28007, Spain. [Perou, C. M.] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27519 USA. RP Prat, A (reprint author), Vall dHebron Inst Oncol, Translat Genom Grp, Pg Vall dHebron 119-129, Barcelona 08035, Spain. EM aprat@vhio.net RI Prat, Aleix/P-8561-2014; IBIS, NUEVAS TERAPIA/P-3415-2015; OI Prat, Aleix/0000-0003-2377-540X; Perou, Charles/0000-0001-9827-2247 FU NCI Breast SPORE program [P50-CA58223-09A1]; Breast Cancer Research Foundation; National Cancer Institute (NCI) Strategic Partnering to Evaluate Cancer Signatures [U01 CA114722-01]; Sociedad Espanola de Oncologia Medica; FEDER [RETICC-RD12/0036/0051, RD12/0036/0042, RD12/0036/0076, RD12/0036/0070]; Instituto de Salud Carlos [III-PI13/01718]; Banco Bilbao Vizcaya Argentaria (BBVA) Foundation; Alliance Statistics and Data Center [U10-CA33601]; [RO1-CA138255] FX This work was supported by funds from the NCI Breast SPORE program Grant No. P50-CA58223-09A1 (CMP), by RO1-CA138255 (CMP), by the Breast Cancer Research Foundation (CMP and MJE), National Cancer Institute (NCI) Strategic Partnering to Evaluate Cancer Signatures Grant No. U01 CA114722-01 (MJE), by the Sociedad Espanola de Oncologia Medica (AP), by FEDER (RETICC-RD12/0036/0051, RD12/0036/0042, RD12/0036/0076, RD12/0036/0070), by Instituto de Salud Carlos III-PI13/01718 (AP), by Banco Bilbao Vizcaya Argentaria (BBVA) Foundation (AP) and by the Alliance Statistics and Data Center (U10-CA33601). NR 44 TC 25 Z9 25 U1 2 U2 25 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-0920 EI 1532-1827 J9 BRIT J CANCER JI Br. J. Cancer PD OCT 14 PY 2014 VL 111 IS 8 BP 1532 EP 1541 DI 10.1038/bjc.2014.444 PG 10 WC Oncology SC Oncology GA AR9YE UT WOS:000343932600009 PM 25101563 ER PT J AU Ahern, CH Shih, YCT Dong, W Parmigiani, G Shen, Y AF Ahern, C. H. Shih, Y-C T. Dong, W. Parmigiani, G. Shen, Y. TI Cost-effectiveness of alternative strategies for integrating MRI into breast cancer screening for women at high risk SO BRITISH JOURNAL OF CANCER LA English DT Article DE breast cancer; screening; cost-effectiveness; mammogram; MRI ID BRCA1/2 MUTATION CARRIERS; ADJUVANT CHEMOTHERAPY; STAGE-II; SOCIETY GUIDELINES; FAMILIAL RISK; MAMMOGRAPHY; LIFE; TRASTUZUMAB; POPULATION; PREVENTION AB Background: Magnetic resonance imaging (MRI) is recommended for women at high risk for breast cancer. We evaluated the cost-effectiveness of alternative screening strategies involving MRI. Methods: Using a microsimulation model, we generated life histories under different risk profiles, and assessed the impact of screening on quality-adjusted life-years, and lifetime costs, both discounted at 3%. We compared 12 screening strategies combining annual or biennial MRI with mammography and clinical breast examination (CBE) in intervals of 0.5, 1, or 2 years vs without, and reported incremental cost-effectiveness ratios (ICERs). Results: Based on an ICER threshold of $100 000/QALY, the most cost-effective strategy for women at 25% lifetime risk was to stagger MRI and mammography plus CBE every year from age 30 to 74, yielding ICER $58 400 (compared to biennial MRI alone). At 50% lifetime risk and with 70% reduction in MRI cost, the recommended strategy was to stagger MRI and mammography plus CBE every 6 months (ICER = $84 400). At 75% lifetime risk, the recommended strategy is biennial MRI combined with mammography plus CBE every 6 months (ICER = $62 800). Conclusions: The high costs of MRI and its lower specificity are limiting factors for annual screening schedule of MRI, except for women at sufficiently high risk. C1 [Ahern, C. H.] Baylor Coll Med, Div Biostat, Dept Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA. [Shih, Y-C T.] Univ Chicago, Sect Hosp Med, Dept Med, Chicago, IL 60637 USA. [Dong, W.; Shen, Y.] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA. [Parmigiani, G.] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Parmigiani, G.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. RP Shen, Y (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Biostat, 1515 Holcombe Blvd,Unit 1411, Houston, TX 77030 USA. EM yshen@mdanderson.org FU National Institutes of Health [P30 CA125123, R03HG004055, R21-CA165092, RC1CA145799, 5P30 CA006516-46, R01-CA07466, P30 CA016672] FX This work was supported by the National Institutes of Health (P30 CA125123) to CHA; the National Institutes of Health (R03HG004055, R21-CA165092, and RC1CA145799) to YCS; the National Institutes of Health (5P30 CA006516-46) to GP; and the National Institutes of Health (R01-CA07466, R21-CA165092, and P30 CA016672) to YS. NR 57 TC 7 Z9 7 U1 1 U2 11 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-0920 EI 1532-1827 J9 BRIT J CANCER JI Br. J. Cancer PD OCT 14 PY 2014 VL 111 IS 8 BP 1542 EP 1551 DI 10.1038/bjc.2014.458 PG 10 WC Oncology SC Oncology GA AR9YE UT WOS:000343932600010 PM 25137022 ER PT J AU Baron, SJ Yeh, RW Cohen, DJ AF Baron, Suzanne J. Yeh, Robert W. Cohen, David J. TI The Challenges of Success Maintaining Access to High-Quality Percutaneous Coronary Intervention in the Face of Declining Procedural Volumes SO CIRCULATION LA English DT Editorial Material DE Editorials; cardiac volume; percutaneous coronary intervention; quality of health care ID ACUTE MYOCARDIAL-INFARCTION; SITE CARDIAC-SURGERY; HEART-ASSOCIATION; HOSPITAL VOLUME; OUTCOMES; OPERATOR; DISEASE; PCI; ANGIOGRAPHY; MORTALITY C1 [Baron, Suzanne J.; Cohen, David J.] Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO 64111 USA. [Yeh, Robert W.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. RP Cohen, DJ (reprint author), Univ Missouri, Sch Med, St Lukes Mid Amer Heart Inst, 4401 Wornall Rd, Kansas City, MO 64111 USA. EM dcohen@saint-lukes.org NR 24 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD OCT 14 PY 2014 VL 130 IS 16 BP 1343 EP 1345 DI 10.1161/CIRCULATIONAHA.114.012640 PG 3 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AR9DS UT WOS:000343872700009 PM 25189216 ER PT J AU Maddox, TM Stanislawski, MA O'Donnell, C Plomondon, ME Bradley, SM Ho, PM Tsai, TT Shroff, AR Speiser, B Jesse, RJ Rumsfeld, JS AF Maddox, Thomas M. Stanislawski, Maggie A. O'Donnell, Colin Plomondon, Mary E. Bradley, Steven M. Ho, P. Michael Tsai, Thomas T. Shroff, Adhir R. Speiser, Bernadette Jesse, Robert J. Rumsfeld, John S. TI Patient Access and 1-Year Outcomes of Percutaneous Coronary Intervention Facilities With and Without On-Site Cardiothoracic Surgery Insights From the Veterans Affairs (VA) Clinical Assessment, Reporting, and Tracking (CART) Program SO CIRCULATION LA English DT Article DE angioplasty; registries; stents; surgery ID CARDIOVASCULAR DATA REGISTRY; CARDIAC-SURGERY; RISK; HOSPITALS; PCI; PREDICTION; THERAPY; CENTERS AB Background-The safety of percutaneous coronary intervention (PCI) at medical facilities without on-site cardiothoracic (CT) surgery has been established in clinical trials. However, the comparative effectiveness of this strategy in real-world practice, including impact on patient access and outcomes, is uncertain. The Veterans Affairs (VA) health care system has used this strategy, with strict quality oversight, since 2005, and can provide insight into this question. Methods and Results-Among 24 387 patients receiving PCI at VA facilities between October 2007 and September 2010, 6616 (27.1%) patients underwent PCI at facilities (n=18) without on-site CT surgery. Patient drive time (as a proxy for access), procedural complications, 1-year mortality, myocardial infarction, and rates of subsequent revascularization procedures were compared by facility. Results were stratified by procedural indication (ST-segment-elevation myocardial infarction versus non-ST-segment-elevation myocardial infarction/unstable angina versus elective) and PCI volume. With the inclusion of PCI facilities without on-site CT surgery, median drive time for patients treated at those facilities decreased by 90.8 minutes (P<0.001). Procedural need for emergent coronary artery bypass graft and mortality rates were low and similar between facilities. Adjusted 1-year mortality and myocardial infarction rates were similar between facilities (hazard ratio in PCI facilities without relative to those with on-site CT surgery, 1.02; 95% confidence interval, 0.87-1.2), and not modified by either PCI indication or PCI volume. Subsequent revascularization rates were higher at sites without on-site CT surgery facilities (hazard ratio, 1.21; 95% confidence interval, 1.03-1.42). Conclusions-This study suggests that providing PCI facilities without on-site CT surgery in an integrated health care system with quality oversight improves patient access without compromising procedural or 1-year outcomes. C1 [Maddox, Thomas M.; Stanislawski, Maggie A.; O'Donnell, Colin; Plomondon, Mary E.; Bradley, Steven M.; Ho, P. Michael; Tsai, Thomas T.; Rumsfeld, John S.] VA Eastern Colorado Hlth Care Syst, Denver, CO 80220 USA. [Maddox, Thomas M.; Stanislawski, Maggie A.; O'Donnell, Colin; Plomondon, Mary E.; Ho, P. Michael; Tsai, Thomas T.; Rumsfeld, John S.] Univ Colorado, Sch Med, Denver, CO USA. [Tsai, Thomas T.] Kaiser Permanente Colorado, Denver, CO USA. [Shroff, Adhir R.; Speiser, Bernadette] Jesse Brown VA Med Ctr, Chicago, IL USA. [Jesse, Robert J.] Vet Hlth Adm, US Dept Vet Affairs, Washington, DC USA. RP Maddox, TM (reprint author), VA Eastern Colorado Hlth Care Syst, Cardiol 111B,1055 Clermont St, Denver, CO 80220 USA. EM thomas.maddox@va.gov FU Department of Veterans Affairs Health Services Research and Development career development awards FX Drs Maddox and Bradley are supported by the Department of Veterans Affairs Health Services Research and Development career development awards. The views in this manuscript are the authors' own and do not necessarily reflect those of the US Department of Veterans Affairs. NR 20 TC 4 Z9 4 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD OCT 14 PY 2014 VL 130 IS 16 BP 1383 EP 1391 DI 10.1161/CIRCULATIONAHA.114.009713 PG 9 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AR9DS UT WOS:000343872700014 PM 25189215 ER PT J AU Chaddha, A Kline-Rogers, E Woznicki, EM Brook, R Housholder-Hughes, S Braverman, AC Pitler, L Hirsch, AT Eagle, KA AF Chaddha, Ashish Kline-Rogers, Eva Woznicki, Elise M. Brook, Robert Housholder-Hughes, Susan Braverman, Alan C. Pitler, Linda Hirsch, Alan T. Eagle, Kim A. TI Activity Recommendations for Postaortic Dissection Patients SO CIRCULATION LA English DT Editorial Material ID BLOOD-PRESSURE; EXERCISE C1 [Chaddha, Ashish; Kline-Rogers, Eva; Woznicki, Elise M.; Brook, Robert; Housholder-Hughes, Susan; Eagle, Kim A.] Univ Michigan, Cardiovasc Ctr, Troy, MI 48098 USA. [Braverman, Alan C.] Washington Univ, Cardiovasc Div, St Louis, MO USA. [Pitler, Linda] Massachusetts Gen Hosp, Thorac Aort Ctr, Boston, MA 02114 USA. [Hirsch, Alan T.] Univ Minnesota Physicians Heart Practice, Cardiovasc Div, Minneapolis, MN USA. RP Chaddha, A (reprint author), Univ Michigan, Cardiovasc Ctr, 6665 Crabapple Court, Troy, MI 48098 USA. EM achaddha@med.umich.edu NR 4 TC 3 Z9 3 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD OCT 14 PY 2014 VL 130 IS 16 BP E140 EP E142 DI 10.1161/CIRCULATIONAHA.113.005819 PG 3 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AR9DS UT WOS:000343872700002 PM 25311622 ER PT J AU Herce, ME Elmore, SN Kalanga, N Keck, JW Wroe, EB Phiri, A Mayfield, A Chingoli, F Beste, JA Tengatenga, L Bazile, J Krakauer, EL Rigodon, J AF Herce, Michael E. Elmore, Shekinah N. Kalanga, Noel Keck, James W. Wroe, Emily B. Phiri, Atupere Mayfield, Alishya Chingoli, Felix Beste, Jason A. Tengatenga, Listern Bazile, Junior Krakauer, Eric L. Rigodon, Jonas TI Assessing and Responding to Palliative Care Needs in Rural Sub-Saharan Africa: Results from a Model Intervention and Situation Analysis in Malawi SO PLOS ONE LA English DT Article ID DEVELOPING-COUNTRIES; SYMPTOM EXPERIENCE; EASTERN CAPE; SOUTH-AFRICA; OF-LIFE; HIV; BURDEN; CANCER; HEALTH; UGANDA AB Introduction: Palliative care is rarely accessible in rural sub-Saharan Africa. Partners In Health and the Malawi government established the Neno Palliative Care Program (NPCP) to provide palliative care in rural Neno district. We conducted a situation analysis to evaluate early NPCP outcomes and better understand palliative care needs, knowledge, and preferences. Methods: Employing rapid evaluation methodology, we collected data from 3 sources: 1) chart review of all adult patients from the NPCP's first 9 months; 2) structured interviews with patients and caregivers; 3) semi-structured interviews with key stakeholders. Results: The NPCP enrolled 63 patients in its first 9 months. Frequent diagnoses were cancer (n = 50, 79%) and HIV/AIDS (n = 37 of 61, 61%). Nearly all (n = 31, 84%) patients with HIV/AIDS were on antiretroviral therapy. Providers registered 112 patient encounters, including 22 (20%) home visits. Most (n = 43, 68%) patients had documented pain at baseline, of whom 23 (53%) were treated with morphine. A majority (n = 35, 56%) had >= 1 follow-up encounter. Mean African Palliative Outcome Scale pain score decreased non-significantly between baseline and follow-up (3.0 vs. 2.7, p = 0.5) for patients with baseline pain and complete pain assessment documentation. Providers referred 48 (76%) patients for psychosocial services, including community health worker support, socioeconomic assistance, or both. We interviewed 36 patients referred to the NPCP after the chart review period. Most had cancer (n = 19, 53%) or HIV/AIDS (n = 10, 28%). Patients frequently reported needing income (n = 24, 67%) or food (n = 22, 61%). Stakeholders cited a need to make integrated palliative care widely available. Conclusions: We identified a high prevalence of pain and psychosocial needs among patients with serious chronic illnesses in rural Malawi. Early NPCP results suggest that comprehensive palliative care can be provided in rural Africa by integrating disease-modifying treatment and palliative care, linking hospital, clinic, and home-based services, and providing psychosocial support that includes socioeconomic assistance. C1 [Herce, Michael E.] Univ N Carolina, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27514 USA. [Herce, Michael E.; Kalanga, Noel; Keck, James W.; Wroe, Emily B.; Phiri, Atupere; Beste, Jason A.; Bazile, Junior; Rigodon, Jonas] Abwenzi Pa Za Umoyo, Neno, Malawi. [Herce, Michael E.; Kalanga, Noel; Keck, James W.; Wroe, Emily B.; Phiri, Atupere; Beste, Jason A.; Bazile, Junior; Krakauer, Eric L.; Rigodon, Jonas] Partners Hlth, Boston, MA USA. [Elmore, Shekinah N.; Krakauer, Eric L.] Harvard Univ, Sch Med, Dept Global Hlth & Social Med, Boston, MA USA. [Wroe, Emily B.; Mayfield, Alishya] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Chingoli, Felix; Tengatenga, Listern] Govt Republ Malawi, Minist Hlth, Neno Dist Hosp, Neno Dist Hlth Off, Neno, Malawi. [Krakauer, Eric L.] Massachusetts Gen Hosp, Dept Med, Div Palliat Care, Boston, MA 02114 USA. RP Herce, ME (reprint author), Univ N Carolina, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27514 USA. EM michael_herce@med.unc.edu FU True Colours Trust/Waterloo Coalition [TCT 833]; Diana Princess of Wales Memorial Fund [URN6650/3423]; US National Institutes of Health [T32 AI007001-36, CTSA UL1TR000083] FX The True Colours Trust/Waterloo Coalition and the Diana Princess of Wales Memorial Fund provided generous financial support for key components of the Neno Palliative Care Program. Grant funding from these organizations was provided under awards TCT 833 and URN6650/3423, respectively. Additional information about these organizations may be found at the following URLs: http://www.truecolourstrust.org.uk; http://www.dianaprincessofwalesmemorialfund.org. This work was supported in part by the US National Institutes of Health, grants T32 AI007001-36 (MH) and CTSA UL1TR000083 (MH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 3 Z9 3 U1 3 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 14 PY 2014 VL 9 IS 10 AR e110457 DI 10.1371/journal.pone.0110457 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AR5ZW UT WOS:000343662500115 PM 25313997 ER PT J AU Camus, M Jensen, DM Matthews, JD Ohning, GV Kovacs, TO Jutabha, R Ghassemi, KA Machicado, GA Dulai, GS AF Camus, Marine Jensen, Dennis M. Matthews, Jason D. Ohning, Gordon V. Kovacs, Thomas O. Jutabha, Rome Ghassemi, Kevin A. Machicado, Gustavo A. Dulai, Gareth S. TI Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Epistaxis; Upper gastrointestinal bleeding; End stage liver disease; Cirrhosis; Nasogastric tube; Liver transplantation; Digestive bleeding; Nasal packing; Coagulopathy ID INTENSIVE-CARE-UNIT; CIRRHOTIC-PATIENTS; SURVIVAL; HEMATEMESIS; OUTCOMES; MODEL AB AIM: To describe the prevalence, diagnosis, treatment, and outcomes of end stage liver disease (ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage (UGIH). METHODS: This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011. RESULTS: A total of 1249 patients were registered for severe UGIH in the data basis, 461 (36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen (75%) subjects required posterior nasal packing and 2 (10%) embolization in addition to correction of coagulopathy. Five (25%) patients died in the hospital, 12 (60%) received orthotopic liver transplantation (OLT), and 3 (15%) were discharged without OLT. The mortality rate was 63% in patients without OLT. CONCLUSION: Severe epistaxis in patients with ESLD is (1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH; and (2) associated with a high mortality rate in patients not receiving OLT. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. C1 [Camus, Marine; Jensen, Dennis M.; Ohning, Gordon V.; Kovacs, Thomas O.; Jutabha, Rome; Ghassemi, Kevin A.; Machicado, Gustavo A.; Dulai, Gareth S.] Univ Calif Los Angeles, David Geffen Sch Med, CURE Digest Dis Res Ctr, CURE Hemostasis Res Grp, Los Angeles, CA 90095 USA. [Camus, Marine; Jensen, Dennis M.; Kovacs, Thomas O.; Jutabha, Rome; Ghassemi, Kevin A.; Machicado, Gustavo A.; Dulai, Gareth S.] Univ Calif Los Angeles, Ronald Reagan Med Ctr, Div Digest Dis, Los Angeles, CA 90095 USA. [Camus, Marine] Univ Paris 07, AP HP, Lariboisiere Hosp, Dept Gastroenterol, F-75010 Paris, France. [Jensen, Dennis M.; Ohning, Gordon V.; Kovacs, Thomas O.; Machicado, Gustavo A.; Dulai, Gareth S.] VA Greater Angeles Healthcare Syst, Div Gastroenterol, Los Angeles, CA 90095 USA. [Matthews, Jason D.] Hunterdon Gastrointestinal Associates, Flemington, NJ 08822 USA. RP Camus, M (reprint author), Lariboisiere Hosp, AP HP, Dept Gastroenterol, 2 Rue Ambroise Pare, F-75010 Paris, France. EM marine.camus@gmail.com FU National Institutes of Health [41301]; Veteran Administration Clinical Merit Review Grant; Philippe Foundation Grant FX Supported by National Institutes of Health, No. 41301; Veteran Administration Clinical Merit Review Grant, to Dr Dennis M Jensen; and Philippe Foundation Grant, to Dr. Marine Camus NR 15 TC 0 Z9 0 U1 0 U2 1 PU BAISHIDENG PUBLISHING GROUP INC PI PLEASANTON PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA SN 1007-9327 EI 2219-2840 J9 WORLD J GASTROENTERO JI World J. Gastroenterol. PD OCT 14 PY 2014 VL 20 IS 38 BP 13993 EP 13998 DI 10.3748/wjg.v20.i38.13993 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AR9GU UT WOS:000343882100037 PM 25320538 ER PT J AU Hoffman, JR Kanzaria, HK AF Hoffman, Jerome R. Kanzaria, Hemal K. TI Intolerance of error and culture of blame drive medical excess SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Editorial Material ID DEFENSIVE MEDICINE; CLINICAL-PRACTICE; MALPRACTICE; CARE; HEALTH; PHYSICIANS; REFORM; COSTS; ASSOCIATION; SPECIALTY AB Jerome R Hoffman and Hemal K Kanzaria argue that efforts to reduce overdiagnosis and overtreatment should focus on changing professional and public attitudes towards medical error and uncertainty C1 [Hoffman, Jerome R.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA. [Kanzaria, Hemal K.] Univ Calif Los Angeles, Robert Wood Johnson Fdn Clin Scholars Program, US Dept Vet Affairs, Ctr Emergency Med, Los Angeles, CA 90024 USA. RP Hoffman, JR (reprint author), Univ Calif Los Angeles, Los Angeles, CA 90024 USA. EM jrh@ucla.edu NR 36 TC 17 Z9 17 U1 0 U2 8 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD OCT 14 PY 2014 VL 349 AR g5702 DI 10.1136/bmj.g5702 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AR7NT UT WOS:000343767300001 PM 25315302 ER PT J AU Oberg, AS Bateman, BT AF Oberg, Anna Sara Bateman, Brian T. TI Would recording family history of postpartum haemorrhage make any difference? Reply SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Letter C1 [Oberg, Anna Sara] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Oberg, Anna Sara] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Bateman, Brian T.] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA. [Bateman, Brian T.] Harvard Univ, Sch Med, Boston, MA USA. [Bateman, Brian T.] Brigham & Womens Hosp, Dept Med, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA 02115 USA. RP Oberg, AS (reprint author), Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. EM oberg@hsph.harvard.edu RI Oberg, Anna/M-7469-2014 OI Oberg, Anna/0000-0001-6638-1895 NR 2 TC 0 Z9 0 U1 0 U2 1 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD OCT 14 PY 2014 VL 349 AR g6210 DI 10.1136/bmj.g6210 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AR7NT UT WOS:000343767300022 PM 25316117 ER PT J AU Felker, GM Teerlink, JR Butler, J Hernandez, AF Miller, AB Cotter, G Davison, BA Filippatos, G Greenberg, BH Ponikowski, P Voors, AA Hua, TA Severin, TM Unemori, E Metra, M AF Felker, G. Michael Teerlink, John R. Butler, Javed Hernandez, Adrian F. Miller, Alan B. Cotter, Gad Davison, Beth A. Filippatos, Gerasimos Greenberg, Barry H. Ponikowski, Piotr Voors, Adriaan A. Hua, Tsushung A. Severin, Thomas M. Unemori, Elaine Metra, Marco TI Effect of Serelaxin on Mode of Death in Acute Heart Failure Results From the RELAX-AHF Study SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article DE cause of death; heart failure; relaxin; sudden cardiac death ID LEFT-VENTRICULAR DYSFUNCTION; MYOCARDIAL-INFARCTION; TRIAL; RISK; OUTCOMES AB BACKGROUND Little is known about mode of death after acute heart failure (AHF) hospitalization. In the RELAX-AHF (Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure) study, serelaxin, the recombinant form of human relaxin-2, reduced post-discharge mortality at 180 days in selected patients with AHF. OBJECTIVES The goal of this study was to assess the effect of serelaxin on specific modes of death in patients with AHF. METHODS The RELAX-AHF study randomized 1,161 patients with AHF to 48 h of therapy with intravenous serelaxin or placebo. Patients were followed for vital status through 180 days. A blinded clinical events committee reviewed all deaths and adjudicated a cause of death on the basis of pre-specified criteria. Cox proportional hazard models were used to assess the effect of serelaxin on each mode of death, on the basis of pre-specified groupings of mode of death. RESULTS There were 107 deaths (9.3%): 37 (35%) due to HF, 25 (23%) due to sudden death, 15 (14%) due to other cardiovascular (CV) causes, 19 (18%) due to non-CV causes, and 11 (10%) classified as unknown. The treatment effect of serelaxin was most pronounced on other CV deaths (hazard ratio [HR]: 0.29; 95% CI: 0.12 to 0.73; p = 0.005) and sudden death (HR: 0.46; 95% CI: 0.20 to 1.07; p = 0.065). There was no apparent impact of serelaxin treatment on HF deaths or non-CV deaths. CONCLUSIONS In the RELAX-AHF study, the effects of serelaxin on mortality were primarily driven by reduction in mortality from other CV causes and sudden death, without apparent impact on HF deaths. (Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure [RELAX-AHF]; C1 [Felker, G. Michael; Hernandez, Adrian F.] Duke Univ, Sch Med, Div Cardiol, Durham, NC USA. [Felker, G. Michael; Hernandez, Adrian F.] Duke Univ, Med Ctr, Duke Heart Ctr, Durham, NC 27710 USA. [Teerlink, John R.] Univ Calif San Francisco, Div Cardiol, San Francisco, CA USA. [Teerlink, John R.] San Francisco VA Med Ctr, San Francisco, CA USA. [Butler, Javed] Emory Univ, Div Cardiol, Atlanta, GA 30322 USA. [Miller, Alan B.] Univ Florida, Div Cardiol, Jacksonville, FL USA. [Cotter, Gad; Davison, Beth A.] Momentum Res Inc, Durham, NC USA. [Filippatos, Gerasimos] Athens Univ Hosp, Dept Cardiol, Attikon, Greece. [Greenberg, Barry H.] Univ Calif San Diego, Div Cardiol, San Diego, CA 92103 USA. [Ponikowski, Piotr] Med Univ, Clin Mil Hosp, Dept Cardiol, Wroclaw, Poland. [Voors, Adriaan A.] Univ Groningen, Univ Med Ctr Groningen, Ek, Dept Cardiol, Groningen, Netherlands. [Hua, Tsushung A.] Novartis Pharmaceut, E Hanover, NJ USA. [Severin, Thomas M.] Novartis Pharma AG, Basel, Switzerland. [Unemori, Elaine] Corthera Inc, San Carlos, CA USA. [Metra, Marco] Univ Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Brescia, Italy. RP Felker, GM (reprint author), Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA. EM michael.felker@duke.edu RI Lainscak, Mitja/F-3237-2015; Ponikowski, Piotr/O-6454-2015; Hernandez, Adrian F./A-7818-2016 OI Ponikowski, Piotr/0000-0002-3391-7064; Davison, Beth/0000-0003-2374-6449; Hernandez, Adrian F./0000-0003-3387-9616 FU Novartis; Amgen; Bayer; BG Medicine; CardioCell; Celladon; Gambro; GE Healthcare; Medtronic; Ono Pharmaceutical; Takeda; Trevena; Zensun; St. Jude Medical; BioControl; Pfizer; Respicardia; Merck; NovaCardia; Sorbent Therapeutics; Corthera; ChanRx; Cardio3; Servier Laboratories FX Drs. Felker and Teerlink have received consulting fees and research grants from Novartis. Dr. Butler has received consulting fees from Novartis, Amgen, Bayer, BG Medicine, CardioCell, Celladon, Gambro, GE Healthcare, Medtronic, Ono Pharmaceutical, Takeda, Trevena, and Zensun. Drs. Hernandez, Filippatos, Greenberg, Ponikowski, and Voors have received consulting fees from Novartis. Dr. Miller has received consulting fees from Novartis, St. Jude Medical, BioControl, Pfizer, Bayer, Respicardia, and Celladon. Drs. Cotter and Davison are employees of Momentum Research, which provided consulting and trial management services to Novartis and received research funding from Merck, NovaCardia, Sorbent Therapeutics, Trevena, Corthera, Novartis, ChanRx, Amgen, and Cardio3. Drs. Hua and Severin are employees of Novartis Pharma AG. Dr. Unemori is a former employee of Corthera, Inc. (a Novartis company). Dr. Metra has received consulting fees from Novartis, Bayer, and Servier Laboratories. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. NR 21 TC 18 Z9 19 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 EI 1558-3597 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD OCT 14 PY 2014 VL 64 IS 15 BP 1591 EP 1598 DI 10.1016/j.jacc.2014.05.071 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AR3EK UT WOS:000343470400009 PM 25301463 ER PT J AU Augustyn, A Borromeo, M Wang, T Fujimoto, J Shao, C Dospoy, PD Lee, V Tan, C Sullivan, JP Larsen, JE Girard, L Behrens, C Wistuba, II Xie, Y Cobb, MH Gazdar, AF Johnson, JE Minna, JD AF Augustyn, Alexander Borromeo, Mark Wang, Tao Fujimoto, Junya Shao, Chunli Dospoy, Patrick D. Lee, Victoria Tan, Christopher Sullivan, James P. Larsen, Jill E. Girard, Luc Behrens, Carmen Wistuba, Ignacio I. Xie, Yang Cobb, Melanie H. Gazdar, Adi F. Johnson, Jane E. Minna, John D. TI ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE ASCL1 transcriptome; target discovery; personalized therapy ID ACHAETE-SCUTE HOMOLOG-1; SMALL-CELL; EPITHELIAL-CELLS; GENE; CARCINOMAS; INHIBITOR; SURVIVAL; ADENOCARCINOMA; CLASSIFICATION; BCL-2 AB Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for approximately 40,000 new lung cancer cases per year in the United States. No targeted therapy exists for these tumors. We determined that achaetescute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the survival of a majority of lung cancers (both SCLC and NSCLC) with neuroendocrine features. By combining whole-genome microarray expression analysis performed on lung cancer cell lines with ChIP-Seq data designed to identify conserved transcriptional targets of ASCL1, we discovered an ASCL1 target 72-gene expression signature that (i) identifies neuroendocrine differentiation in NSCLC cell lines, (ii) is predictive of poor prognosis in resected NSCLC specimens from three datasets, and (iii) represents novel "druggable" targets. Among these druggable targets is B-cell CLL/lymphoma 2, which when pharmacologically inhibited stops ASCL1-dependent tumor growth in vitro and in vivo and represents a proof-of-principle ASCL1 downstream target gene. Analysis of downstream targets of ASCL1 represents an important advance in the development of targeted therapy for the neuroendocrine class of lung cancers, providing a significant step forward in the understanding and therapeutic targeting of the molecular vulnerabilities of neuroendocrine lung cancer. C1 [Augustyn, Alexander; Shao, Chunli; Dospoy, Patrick D.; Lee, Victoria; Tan, Christopher; Girard, Luc; Gazdar, Adi F.; Minna, John D.] Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75235 USA. [Augustyn, Alexander; Wang, Tao; Shao, Chunli; Dospoy, Patrick D.; Girard, Luc; Xie, Yang; Cobb, Melanie H.; Gazdar, Adi F.; Minna, John D.] Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75235 USA. [Borromeo, Mark; Johnson, Jane E.] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75235 USA. [Wang, Tao; Xie, Yang] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75235 USA. [Girard, Luc; Cobb, Melanie H.; Johnson, Jane E.; Minna, John D.] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75235 USA. [Gazdar, Adi F.] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75235 USA. [Minna, John D.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75235 USA. [Fujimoto, Junya; Behrens, Carmen; Wistuba, Ignacio I.] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA. [Fujimoto, Junya; Behrens, Carmen; Wistuba, Ignacio I.] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA. [Sullivan, James P.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Larsen, Jill E.] QIMR Berghofer Med Res Inst, Oncogen Lab, Brisbane, Qld 4006, Australia. RP Minna, JD (reprint author), Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75235 USA. EM john.minna@utsouthwestern.edu RI Larsen, Jill/G-3787-2010; Wang, Tao/K-3518-2016; OI Larsen, Jill/0000-0001-7806-3931; Cobb, Melanie/0000-0003-0833-5473 FU National Cancer Institute Specialized Program of Research Excellence in Lung Cancer [P50CA70907]; National Cancer Institute [CTD2N CA176284]; Cancer Prevention and Research Institute of Texas [RP110708, RP110383]; University of Texas Southwestern Medical Center Medical Scientist Training Program; Ruth L. Kirschstein National Research Service Award [F30: 1F30CA168264] FX We thank all of the members of the J.D.M. laboratory for critical discussions and experimental support. This work was supported by National Cancer Institute Specialized Program of Research Excellence in Lung Cancer Grant P50CA70907, National Cancer Institute Grant CTD2N CA176284, and Cancer Prevention and Research Institute of Texas Grants RP110708 (to J.D.M., I.I.W., Y.X., and L.G.) and RP110383 (to J.E.J. and M.H.C.). A.A. is supported by the University of Texas Southwestern Medical Center Medical Scientist Training Program and by a Ruth L. Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows (F30: 1F30CA168264). NR 38 TC 33 Z9 34 U1 1 U2 9 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 14 PY 2014 VL 111 IS 41 BP 14788 EP 14793 DI 10.1073/pnas.1410419111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ6KW UT WOS:000342922000047 PM 25267614 ER PT J AU Balbas, MD Burgess, MR Murali, R Wongvipat, J Skaggs, BJ Mundel, P Weins, A Sawyers, CL AF Balbas, Minna D. Burgess, Michael R. Murali, Rajmohan Wongvipat, John Skaggs, Brian J. Mundel, Peter Weins, Astrid Sawyers, Charles L. TI MAGI-2 scaffold protein is critical for kidney barrier function SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE MAGI-2/S-SCAM; glomerulosclerosis ID D-ASPARTATE RECEPTORS; PDZ-DOMAIN; GLOMERULAR-DISEASE; NEPHROTIC SYNDROME; TUMOR-SUPPRESSOR; GUANYLATE KINASE; CELL POLARITY; MEMBRANE; NEPHRIN; PODOCYTES AB MAGUK Inverted 2 (MAGI-2) is a PTEN-interacting scaffold protein implicated in cancer on the basis of rare, recurrent genomic translocations and deletions in various tumors. In the renal glomerulus, MAGI-2 is exclusively expressed in podocytes, specialized cells forming part of the glomerular filter, where it interacts with the slit diaphragm protein nephrin. To further explore MAGI-2 function, we generated Magi-2-KO mice through homologous recombination by targeting an exon common to all three alternative splice variants. Magi-2 null mice presented with progressive proteinuria as early as 2 wk postnatally, which coincided with loss of nephrin expression in the glomeruli. Magi-2-null kidneys revealed diffuse podocyte foot process effacement and focal podocyte hypertrophy by 3 wk of age, as well as progressive podocyte loss. By 5.5 wk, coinciding with a near-complete loss of podocytes, Magi-2-nullmice developed diffuse glomerular extracapillary epithelial cell proliferations, and died of renal failure by 3 mo of age. As confirmed by immunohistochemical analysis, the proliferative cell populations in glomerular lesions were exclusively composed of activated parietal epithelial cells (PECs). Our results reveal that MAGI-2 is required for the integrity of the kidney filter and podocyte survival. Moreover, we demonstrate that PECs can be activated to form glomerular lesions resembling a noninflammatory glomerulopathy with extensive extracapillary proliferation, sometimes resembling crescents, following rapid and severe podocyte loss. C1 [Balbas, Minna D.; Wongvipat, John; Sawyers, Charles L.] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA. [Murali, Rajmohan] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. [Murali, Rajmohan] Mem Sloan Kettering Canc Ctr, Marie Josee & Henry R Kravis Ctr Mol Oncol, New York, NY 10021 USA. [Sawyers, Charles L.] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA. [Burgess, Michael R.] Univ Calif San Francisco, Dept Med, Div Hematol & Oncol, San Francisco, CA 94143 USA. [Skaggs, Brian J.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA. [Mundel, Peter] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Boston, MA 02114 USA. [Weins, Astrid] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02114 USA. RP Sawyers, CL (reprint author), Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA. EM sawyersc@mskcc.org RI Sawyers, Charles/G-5327-2016; Murali, Rajmohan/A-7960-2008 OI Murali, Rajmohan/0000-0001-6988-4295 FU American Cancer Society Hillcrest Committee [PF-14-146-01-LIB]; National Institutes of Health (NIH) Mentored Clinical Scientist Career Development Award [K08 DK0933783]; NIH [DK057683, DK062472, DK091218] FX We thank Dr. Marilyn Farquhar for helpful discussions during the early phases of this work; the molecular cytology core facility and colony management group at Memorial Sloan-Kettering Cancer Center for technical support; Celine Chiu for assistance with transmission electron microscopy; Drs. Hong Wu and Meisheng Jiang and the University of California, Los Angeles, transgenic facility and ES cell core for technical assistance; and Terri Woo at the Brigham and Women's Hospital renal pathology laboratory for expert technical assistance. M.R.B. is supported by Postdoctoral Fellowship PF-14-146-01-LIB from the American Cancer Society Hillcrest Committee. This work was supported by National Institutes of Health (NIH) Mentored Clinical Scientist Career Development Award K08 DK0933783 (to A.W.) and NIH Grants DK057683, DK062472, and DK091218 (to P.M.). NR 40 TC 6 Z9 6 U1 1 U2 4 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 14 PY 2014 VL 111 IS 41 BP 14876 EP 14881 DI 10.1073/pnas.1417297111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ6KW UT WOS:000342922000062 PM 25271328 ER PT J AU Fox, MD Buckner, RL Liu, HS Chakravarty, MM Lozano, AM Pascual-Leone, A AF Fox, Michael D. Buckner, Randy L. Liu, Hesheng Chakravarty, M. Mallar Lozano, Andres M. Pascual-Leone, Alvaro TI Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE human connectome project; neurosurgery; TMS; tDCS; clinical application ID TRANSCRANIAL MAGNETIC STIMULATION; INTRINSIC FUNCTIONAL CONNECTIVITY; DORSOLATERAL PREFRONTAL CORTEX; TREATMENT-RESISTANT DEPRESSION; OBSESSIVE-COMPULSIVE DISORDER; MINIMALLY CONSCIOUS STATE; GLOBAL SIGNAL REGRESSION; HUMAN CONNECTOME PROJECT; DEEP-BRAIN; PARKINSONS-DISEASE AB Brain stimulation, a therapy increasingly used for neurological and psychiatric disease, traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and noninvasive approaches, such as transcranial magnetic stimulation. The relationship between these approaches is unknown, therapeutic mechanisms remain unclear, and the ideal stimulation site for a given technique is often ambiguous, limiting optimization of the stimulation and its application in further disorders. In this article, we identify diseases treated with both types of stimulation, list the stimulation sites thought to be most effective in each disease, and test the hypothesis that these sites are different nodes within the same brain network as defined by resting-state functional-connectivity MRI. Sites where DBS was effective were functionally connected to sites where noninvasive brain stimulation was effective across diseases including depression, Parkinson's disease, obsessive-compulsive disorder, essential tremor, addiction, pain, minimally conscious states, and Alzheimer's disease. A lack of functional connectivity identified sites where stimulation was ineffective, and the sign of the correlation related to whether excitatory or inhibitory noninvasive stimulation was found clinically effective. These results suggest that resting-state functional connectivity may be useful for translating therapy between stimulation modalities, optimizing treatment, and identifying new stimulation targets. More broadly, this work supports a network perspective toward understanding and treating neuropsychiatric disease, highlighting the therapeutic potential of targeted brain network modulation. C1 [Fox, Michael D.; Pascual-Leone, Alvaro] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat,Dept N, Boston, MA 02215 USA. [Fox, Michael D.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Fox, Michael D.; Buckner, Randy L.; Liu, Hesheng] Harvard Univ, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02129 USA. [Buckner, Randy L.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Buckner, Randy L.] Harvard Univ, Ctr Brain Sci, Dept Psychol, Cambridge, MA 02138 USA. [Chakravarty, M. Mallar] Douglas Mental Hlth Inst, Cerebral Imaging Ctr, Verdun, PQ H4H 1R3, Canada. [Chakravarty, M. Mallar] McGill Univ, Dept Psychiat, Montreal, PQ H3A 2B4, Canada. [Chakravarty, M. Mallar] McGill Univ, Dept Biomed Engn, Montreal, PQ H3A 2B4, Canada. [Lozano, Andres M.] Toronto Western Hosp, Dept Surg, Div Neurosurg, Toronto, ON M5T 2S8, Canada. [Lozano, Andres M.] Univ Toronto, Krembil Neurosci Ctr, Toronto, ON M5T 2S8, Canada. RP Fox, MD (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat,Dept N, Boston, MA 02215 USA. EM foxmdphd@gmail.com FU National Institutes of Health [K23NS083741, R01HD069776, R01NS073601, R21MH099196, R21NS082870, R21NS085491, R21HD07616]; American Academy of Neurology/American Brain Foundation [UL1 RR025758]; Harvard Clinical and Translational Science Center/Harvard Catalyst; Michael J. Fox Foundation; Sidney R. Baer Foundation; National Football League Players Association FX We thank Andreas Horn for supplying the group-level diffusion MRI data, Danhong Wang for assistance with data processing, Giulio Ruffini for helpful discussions regarding multifocal tDCS, Thomas Yeo for algorithms used in rs-fcMRI processing, Elisa Wilker for statistical advice, and the Brain Genomics Superstruct Project for contributing data. Work on this study was supported in part by National Institutes of Health Grants K23NS083741, R01HD069776, R01NS073601, R21MH099196, R21NS082870, R21NS085491, and R21HD07616; by Grant UL1 RR025758 from the American Academy of Neurology/American Brain Foundation; by Harvard Clinical and Translational Science Center/Harvard Catalyst; and by the Michael J. Fox Foundation, the Sidney R. Baer Foundation, and the National Football League Players Association. NR 202 TC 65 Z9 65 U1 16 U2 55 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 14 PY 2014 VL 111 IS 41 BP E4367 EP E4375 DI 10.1073/pnas.1405003111 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ6KW UT WOS:000342922000015 PM 25267639 ER PT J AU Lee, S Truesdell, SS Bukhari, SIA Lee, JH LeTonqueze, O Vasudevan, S AF Lee, Sooncheol Truesdell, Samuel S. Bukhari, Syed I. A. Lee, Ju Huck LeTonqueze, Olivier Vasudevan, Shobha TI Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE embryonic stem cells; early serum starvation; eIF2 alpha phosphorylation ID EUKARYOTIC TRANSLATION INITIATION; VESICULAR STOMATITIS-VIRUS; GENE-EXPRESSION; XENOPUS-OOCYTES; 40S RIBOSOME; SUBUNITS; PHOSPHORYLATION; MECHANISMS; COMPLEX; GROWTH AB Proliferation arrest and distinct developmental stages alter and decrease general translation yet maintain ongoing translation. The factors that support translation in these conditions remain to be characterized. We investigated an altered translation factor in three cell states considered to have reduced general translation: immature Xenopus laevis oocytes, mouse ES cells, and the transition state of proliferating mammalian cells to quiescence (G0) upon growth- factor deprivation. Our data reveal a transient increase of eukaryotic translation initiation factor 5B (eIF5B), the eukaryotic ortholog of bacterial initiation factor IF2, in these conditions. eIF5B promotes 60S ribosome subunit joining and pre- 40S subunit proofreading. eIF5B has also been shown to promote the translation of viral and stress- related mRNAs and can contribute indirectly to supporting or stabilizing initiator methionyl tRNA (tRNA- Met(i)) association with the ribosome. We find that eIF5B is a limiting factor for translation in these three conditions. The increased eIF5B levels lead to increased eIF5B complexes with tRNA- Met(i) upon serum starvation of THP1 mammalian cells. In addition, increased phosphorylation of eukaryotic initiation factor 2 alpha, the translation factor that recruits initiator tRNA- Met(i) for general translation, is observed in these conditions. Importantly, we find that eIF5B is an antagonist of G0 and G0- like states, as eIF5B depletion reduces maturation of G0- like, immature oocytes and hastens early G0 arrest in serumstarved THP1 cells. Consistently, eIF5B overexpression promotes maturation of G0- like immature oocytes and causes cell death, an alternative to G0, in serum- starved THP1 cells. These data reveal a critical role for a translation factor that regulates specific cell- cycle transition and developmental stages. C1 [Lee, Sooncheol; Truesdell, Samuel S.; Bukhari, Syed I. A.; Lee, Ju Huck; LeTonqueze, Olivier; Vasudevan, Shobha] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc Res, Boston, MA 02114 USA. RP Vasudevan, S (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc Res, Boston, MA 02114 USA. EM vasudevan.shobha@mgh.harvard.edu FU Cancer Research Institute; D. and M.-E. Ryder, Smith Family Foundation; Leukemia and Lymphoma Society Investigator awards; Massachusetts General Hospital Start-Up Award FX We thank C. Wilusz for advice, A. Classon and V. Bhambhani for technical assistance, and the Partners Healthcare Center for Personalized Genetic Medicine Microarray facility for assistance with microarray analysis. This study was supported by the Cancer Research Institute, the D. and M.-E. Ryder, Smith Family Foundation, the Leukemia and Lymphoma Society Investigator awards, and by Massachusetts General Hospital Start-Up Award (to S.V.). NR 31 TC 8 Z9 8 U1 0 U2 8 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 14 PY 2014 VL 111 IS 41 BP E4315 EP E4322 DI 10.1073/pnas.1320477111 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ6KW UT WOS:000342922000009 PM 25261552 ER PT J AU Costa, C Engelman, JA AF Costa, Carlotta Engelman, Jeffrey A. TI The Double Life of p85 SO CANCER CELL LA English DT Editorial Material ID MUTATIONS; CANCER; OPPORTUNITIES; P85-ALPHA; 3-KINASE; SUBUNIT; PTEN AB A growing number of mutations in PIK3R1, the gene that encodes for the p85a regulatory subunit of PI3K, have been recently identified. In this issue of Cancer Cell, Cheung and colleagues describe two neomorphic PIK3R1 mutants prevalent in endometrial and colon cancer that induce transformationnvia activation of PI3Kindependent pathways. C1 [Costa, Carlotta; Engelman, Jeffrey A.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA. RP Engelman, JA (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA. EM jengelman@mgh.harvard.edu NR 10 TC 1 Z9 1 U1 0 U2 2 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1535-6108 EI 1878-3686 J9 CANCER CELL JI Cancer Cell PD OCT 13 PY 2014 VL 26 IS 4 BP 445 EP 447 PG 3 WC Oncology; Cell Biology SC Oncology; Cell Biology GA AR1KJ UT WOS:000343343800002 PM 25314071 ER PT J AU Schwarz, DS Blower, MD AF Schwarz, Dianne S. Blower, Michael D. TI The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation SO JOURNAL OF CELL BIOLOGY LA English DT Article ID XENOPUS EGG EXTRACTS; SMALL NUCLEOLAR RNA; NUCLEAR VESICLE FUSION; FUNCTION IN-VITRO; ENDOPLASMIC-RETICULUM; MAMMALIAN-CELLS; MEMBRANE-PROTEINS; HOMOTYPIC FUSION; ENDORIBONUCLEASE; LAEVIS AB How cells shape and remodel organelles in response to cellular signals is a poorly understood process. Using Xenopus Iaevis egg extract, we found that increases in cytosolic calcium lead to the activation of an endogenous ribonuclease, XendoU. A fraction of XendoU localizes to the endoplasmic reticulum (ER) and is required for nuclear envelope assembly and ER network formation in a catalysis-dependent manner. Using a purified vesicle fusion assay, we show that XendoU functions on the surface of ER membranes to promote RNA cleavage and ribonucleoprotein (RNP) removal. Additionally, RNA removal from the surface of vesicles by RNase treatment leads to increased ER network formation. Using human tissue culture cells, we found that hEndoU localizes to the ER, where it promotes the formation of ER tubules in a catalysis-dependent manner. Together, these results demonstrate that calcium-activated removal of RNA from membranes by XendoU promotes and refines ER remodeling and the formation of tubular ER. C1 [Schwarz, Dianne S.; Blower, Michael D.] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. [Schwarz, Dianne S.; Blower, Michael D.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. RP Blower, MD (reprint author), Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. EM blower@molbio.mgh.harvard.edu FU Jane Coffin Childs Memorial Fund; Massachusetts General Hospital Executive Committee on Research (ECOR) Fund; Burroughs Wellcome Fund FX This work was supported by a Jane Coffin Childs Memorial Fund for Medical Research postdoctoral fellowship to D.S. Schwarz, a Massachusetts General Hospital Executive Committee on Research (ECOR) Fund for Medical Discovery award to D.S. Schwarz, and a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund to M.D. Blower. NR 80 TC 4 Z9 4 U1 1 U2 4 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA SN 0021-9525 EI 1540-8140 J9 J CELL BIOL JI J. Cell Biol. PD OCT 13 PY 2014 VL 207 IS 1 BP 41 EP 57 DI 10.1083/jcb.201406037 PG 17 WC Cell Biology SC Cell Biology GA AQ9SB UT WOS:000343194900007 PM 25287301 ER PT J AU Horan, WP Wynn, JK Mathis, I Miller, GA Green, MF AF Horan, William P. Wynn, Jonathan K. Mathis, Ian Miller, Gregory A. Green, Michael F. TI Approach and Withdrawal Motivation in Schizophrenia: An Examination of Frontal Brain Asymmetric Activity SO PLOS ONE LA English DT Article ID PSYCHIATRIC RATING-SCALE; EEG-ALPHA ASYMMETRY; AVOIDANCE MOTIVATION; INDIVIDUAL-DIFFERENCES; BEHAVIORAL ACTIVATION; EMOTION REGULATION; QUALITY-ASSURANCE; AFFECTIVE STYLE; DEPRESSION; ANXIETY AB Although motivational disturbances are common in schizophrenia, their neurophysiological and psychological basis is poorly understood. This electroencephalography (EEG) study examined the well-established motivational direction model of asymmetric frontal brain activity in schizophrenia. According to this model, relative left frontal activity in the resting EEG reflects enhanced approach motivation tendencies, whereas relative right frontal activity reflects enhanced withdrawal motivation tendencies. Twenty-five schizophrenia outpatients and 25 healthy controls completed resting EEG assessments of frontal asymmetry in the alpha frequency band (8-12 Hz), as well as a self-report measure of behavioral activation and inhibition system (BIS/BAS) sensitivity. Patients showed an atypical pattern of differences from controls. On the EEG measure patients failed to show the left lateralized activity that was present in controls, suggesting diminished approach motivation. On the self-report measure, patients reported higher BIS sensitivity than controls, which is typically interpreted as heightened withdrawal motivation. EEG asymmetry scores did not significantly correlate with BIS/BAS scores or with clinical symptom ratings among patients. The overall pattern suggests a motivational disturbance in schizophrenia characterized by elements of both diminished approach and elevated withdrawal tendencies. C1 [Horan, William P.; Wynn, Jonathan K.; Mathis, Ian; Green, Michael F.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. [Horan, William P.; Wynn, Jonathan K.; Mathis, Ian; Miller, Gregory A.; Green, Michael F.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Horan, WP (reprint author), VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. EM horan@ucla.edu RI Wynn, Jonathan/H-3749-2014 OI Wynn, Jonathan/0000-0002-1763-8540 FU NARSAD; NIMH [MH043292, MH065707] FX This work received support from a NARSAD Young Investigator Award (WPH), NIMH Grant MH043292 (MFG), and NIMH Grant MH065707 (MFG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 56 TC 4 Z9 4 U1 4 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 13 PY 2014 VL 9 IS 10 AR e110007 DI 10.1371/journal.pone.0110007 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ9WZ UT WOS:000343210300084 PM 25310340 ER PT J AU Pavelitz, T Renfro, L Foster, NR Caracol, A Welsch, P Lao, VV Grady, WB Niedzwiecki, D Saltz, LB Bertagnolli, MM Goldberg, RM Rabinovitch, PS Emond, M Monnat, RJ Maizels, N AF Pavelitz, Thomas Renfro, Lindsay Foster, Nathan R. Caracol, Amber Welsch, Piri Lao, Victoria Valinluck Grady, William B. Niedzwiecki, Donna Saltz, Leonard B. Bertagnolli, Monica M. Goldberg, Richard M. Rabinovitch, Peter S. Emond, Mary Monnat, Raymond J., Jr. Maizels, Nancy TI MRE11-Deficiency Associated with Improved Long-Term Disease Free Survival and Overall Survival in a Subset of Stage III Colon Cancer Patients in Randomized CALGB 89803 Trial SO PLOS ONE LA English DT Article ID DNA MISMATCH REPAIR; MICROSATELLITE INSTABILITY; COLORECTAL-CANCER; MRE11 EXPRESSION; ADJUVANT THERAPY; IRINOTECAN; DAMAGE; CELLS; FLUOROURACIL; LEUCOVORIN AB Purpose: Colon cancers deficient in mismatch repair (MMR) may exhibit diminished expression of the DNA repair gene, MRE11, as a consequence of contraction of a T-11 mononucleotide tract. This study investigated MRE11 status and its association with prognosis, survival and drug response in patients with stage III colon cancer. Patients and Methods: Cancer and Leukemia Group B 89803 (Alliance) randomly assigned 1,264 patients with stage III colon cancer to postoperative weekly adjuvant bolus 5-fluorouracil/leucovorin (FU/LV) or irinotecan+FU/LV (IFL), with 8 year follow-up. Tumors from these patients were analyzed to determine stability of a T-11 tract in the MRE11 gene. The primary endpoint was overall survival (OS), and a secondary endpoint was disease-free survival (DFS). Non-proportional hazards were addressed using time-dependent covariates in Cox analyses. Results: Of 625 tumor cases examined, 70 (11.2%) exhibited contraction at the T-11 tract in one or both MRE11 alleles and were thus predicted to be deficient in MRE11 (dMRE11). In pooled treatment analyses, dMRE11 patients showed initially reduced DFS and OS but improved long-term DFS and OS compared with patients with an intact MRE11 T-11 tract. In the subgroup of dMRE11 patients treated with IFL, an unexplained early increase in mortality but better long-term DFS than IFL-treated pMRE11 patients was observed. Conclusions: Analysis of this relatively small number of patients and events showed that the dMRE11 marker predicts better prognosis independent of treatment in the long-term. In subgroup analyses, dMRE11 patients treated with irinotecan exhibited unexplained short-term mortality. MRE11 status is readily assayed and may therefore prove to be a useful prognostic marker, provided that the results reported here for a relatively small number of patients can be generalized in independent analyses of larger numbers of samples. C1 [Pavelitz, Thomas; Caracol, Amber; Maizels, Nancy] Univ Washington, Dept Immunol, Seattle, WA 98195 USA. [Renfro, Lindsay; Foster, Nathan R.] Mayo Clin, Div Biomed Stat & Informat, Rochester, MN USA. [Caracol, Amber; Maizels, Nancy] Univ Washington, Mol & Cellular Biol Grad Program, Seattle, WA 98195 USA. [Welsch, Piri; Monnat, Raymond J., Jr.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA. [Lao, Victoria Valinluck; Grady, William B.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA. [Lao, Victoria Valinluck] Univ Washington, Sch Med, Dept Surg, Seattle, WA 98195 USA. [Grady, William B.] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA. [Niedzwiecki, Donna] Duke Univ, Med Ctr, Canc & Leukemia Grp B, Ctr Stat, Durham, NC USA. [Saltz, Leonard B.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Bertagnolli, Monica M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Bertagnolli, Monica M.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Goldberg, Richard M.] Ohio State Univ, Columbus, OH 43210 USA. [Rabinovitch, Peter S.; Monnat, Raymond J., Jr.; Maizels, Nancy] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA. [Emond, Mary] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Maizels, Nancy] Univ Washington, Dept Biochem, Seattle, WA 98195 USA. [Pavelitz, Thomas; Renfro, Lindsay] Univ Washington, Dept Chem, Seattle, WA 98195 USA. RP Maizels, N (reprint author), Univ Washington, Dept Immunol, Seattle, WA 98195 USA. EM maizels@u.washington.edu OI Saltz, Leonard/0000-0001-8353-4670 FU National Institutes of Health National Cancer Institute [P01 CA077852]; NIH [F31 GM073318]; HHMI MedIntoGrad Scholar Awards FX Research reported here was supported by National Institutes of Health National Cancer Institute P01 CA077852 (WBG, PSR, RJM, NM); and NIH F31 GM073318 and HHMI MedIntoGrad Scholar Awards (AC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 3 Z9 3 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 13 PY 2014 VL 9 IS 10 AR e108483 DI 10.1371/journal.pone.0108483 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ9WZ UT WOS:000343210300019 PM 25310185 ER PT J AU van Oosterom, MN Kreuger, R Buckle, T Mahn, WA Bunschoten, A Josephson, L van Leeuwen, FWB Beekman, FJ AF van Oosterom, Matthias N. Kreuger, Rob Buckle, Tessa Mahn, Wendy A. Bunschoten, Anton Josephson, Lee van Leeuwen, Fijs W. B. Beekman, Freek J. TI U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform SO EJNMMI RESEARCH LA English DT Article DE Bioluminescence imaging; Fluorescence imaging; Multimodal molecular imaging; SPECT; Small animal; Nuclear medicine ID SMALL-ANIMAL PET; NUCLEAR-MEDICINE; PINHOLE SPECT; SYSTEM; TOMOGRAPHY; RECONSTRUCTION; XENOGRAFTS; VALIDATION; METASTASES; CXCR4 AB Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated separately on individual preclinical systems. In this paper, we introduce a fully integrated bioluminescence-fluorescence-SPECT platform. Next to an optimization in logistics and image fusion, this integration can help improve understanding of the optical imaging (OI) results. Methods: An OI module was developed for a preclinical SPECT system (U-SPECT, MILabs, Utrecht, the Netherlands). The applicability of the module for bioluminescence and fluorescence imaging was evaluated in both a phantom and in an in vivo setting using mice implanted with a 4 T1-luc + tumor. A combination of a fluorescent dye and radioactive moiety was used to directly relate the optical images of the module to the SPECT findings. Bioluminescence imaging (BLI) was compared to the localization of the fluorescence signal in the tumors. Results: Both the phantom and in vivo mouse studies showed that superficial fluorescence signals could be imaged accurately. The SPECT and bioluminescence images could be used to place the fluorescence findings in perspective, e.g. by showing tracer accumulation in non-target organs such as the liver and kidneys (SPECT) and giving a semi-quantitative read-out for tumor spread (bioluminescence). Conclusions: We developed a fully integrated multimodal platform that provides complementary registered imaging of bioluminescent, fluorescent, and SPECT signatures in a single scanning session with a single dose of anesthesia. In our view, integration of these modalities helps to improve data interpretation of optical findings in relation to radionuclide images. C1 [van Oosterom, Matthias N.; Kreuger, Rob; Mahn, Wendy A.; Beekman, Freek J.] Delft Univ Technol, Radiat Detect & Med Imaging, NL-2629 JB Delft, Netherlands. [van Oosterom, Matthias N.; Buckle, Tessa; Bunschoten, Anton; van Leeuwen, Fijs W. B.] Leiden Univ, Med Ctr, Dept Radiol, Intervent Mol Imaging Lab, Leiden, Netherlands. [Josephson, Lee] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Translat Nucl Med & Mol Imaging, Boston, MA USA. [Beekman, Freek J.] MILABS, Utrecht, Netherlands. [Beekman, Freek J.] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands. RP Kreuger, R (reprint author), Delft Univ Technol, Radiat Detect & Med Imaging, Mekelweg 15, NL-2629 JB Delft, Netherlands. EM r.kreuger@tudelft.nl OI van leeuwen, Fijs/0000-0002-6844-4025; Buckle, Tessa/0000-0003-2980-6895 FU Dutch Cancer Society translational research award [PGF 2009-4344]; NWO-STW-VIDI [STW BGT11272] FX This work was partially supported by the Dutch Cancer Society translational research award (Grant no. PGF 2009-4344) and NWO-STW-VIDI (Grant no. STW BGT11272). NR 37 TC 6 Z9 6 U1 0 U2 5 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 2191-219X J9 EJNMMI RES JI EJNMMI Res. PD OCT 11 PY 2014 VL 4 AR 56 DI 10.1186/s13550-014-0056-0 PG 11 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CM9TM UT WOS:000358051900001 PM 25386389 ER PT J AU Wei, N Pan, J Pop-Busui, R Othman, A Alecu, I Hornemann, T Eichler, FS AF Wei, Nancy Pan, Jessica Pop-Busui, Rodica Othman, Alaa Alecu, Irina Hornemann, Thorsten Eichler, Florian S. TI Altered sphingoid base profiles in type 1 compared to type 2 diabetes SO LIPIDS IN HEALTH AND DISEASE LA English DT Article DE Atypical sphingolipids; Biomarker; Deoxysphingolipids; Metabolic syndrome; Type 2 diabetes mellitus; Type 1 diabetes mellitus ID ACCUMULATION; PLASMA AB Background: Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) -an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated. Findings: We analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-linked headgroups in plasma from individuals with T1DM (N = 27), T2DM (N = 30) and healthy controls (N = 23). 1-deoxySLs were significantly higher in the groups with T2DM but not different between T1DM and controls. In contrast to patients with T2DM, 1-deoxSL levels are not elevated in T1DM. Conclusions: Our study indicates that the 1-deoxySL formation is not per-se caused by hyperglycemia but rather specifically associated with metabolic changes in T2DM, such as elevated triglyceride levels. C1 [Wei, Nancy] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Pan, Jessica; Eichler, Florian S.] Harvard Univ, Sch Med, Dept Neurol, MGH Neurosci Ctr, Boston, MA 02114 USA. [Pop-Busui, Rodica] Univ Michigan Hlth Syst, Dept Internal Med Metab Endocrinol & Diabet, Ann Arbor, MI 48109 USA. [Othman, Alaa; Alecu, Irina; Hornemann, Thorsten] Univ Zurich Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland. [Eichler, Florian S.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. RP Eichler, FS (reprint author), Harvard Univ, Sch Med, Dept Neurol, MGH Neurosci Ctr, 55 Fruit St ACC 708, Boston, MA 02114 USA. EM feichler@partners.org RI Othman, Alaa/K-1388-2015 OI Othman, Alaa/0000-0002-0092-5594 FU NIH - NIDDK [P30DK057521-14]; NINDS [R01 NS072446]; Zurich Center of Integrated Human Physiology, University of Zurich; 7th Framework Program of the European Commission ("RESOLVE") [305707]; "radiz"-Rare Disease Initiative Zurich, University of Zurich FX The work was supported by grants from NIH - NIDDK (P30DK057521-14) and NINDS (R01 NS072446), Zurich Center of Integrated Human Physiology, University of Zurich; the 7th Framework Program of the European Commission ("RESOLVE", Project number 305707) and "radiz"-Rare Disease Initiative Zurich, University of Zurich. NR 9 TC 4 Z9 4 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-511X J9 LIPIDS HEALTH DIS JI Lipids Health Dis. PD OCT 11 PY 2014 VL 13 AR 161 DI 10.1186/1476-511X-13-161 PG 4 WC Biochemistry & Molecular Biology; Nutrition & Dietetics SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA AT9KG UT WOS:000345245800001 PM 25305670 ER PT J AU McGrath, ER Espie, CA Murphy, AW Newell, J Power, A Madden, S Byrne, M O'Donnell, MJ AF McGrath, Emer R. Espie, Colin A. Murphy, Andrew W. Newell, John Power, Alice Madden, Sarah Byrne, Molly O'Donnell, Martin J. TI Sleep to lower elevated blood pressure: study protocol for a randomized controlled trial SO TRIALS LA English DT Article DE Sleep; Hypertension; Cardiovascular disease ID COGNITIVE-BEHAVIORAL THERAPY; CLINICAL EFFECTIVENESS TRIAL; RISK-FACTOR; CARDIOVASCULAR-DISEASE; PERSISTENT INSOMNIA; INSUFFICIENT SLEEP; DURATION; HYPERTENSION; METAANALYSIS; ASSOCIATION AB Background: Sleep is an essential component of good physical and mental health. Previous studies have reported that poor quality sleep is associated with an increased risk of hypertension and cardiovascular disease. Hypertension is the most common and important risk factor for cardiovascular disease, and even modest reductions in blood pressure can result in significant reductions in the risk of stroke and myocardial infarction. In this trial, we will determine the efficacy of an online sleep intervention in improving blood pressure, in participants with hypertension and poor sleep quality. Methods: Trial design: Randomized-controlled, two-group, parallel, blinded, single-center, Phase II trial of 134 participants. Population and recruitment: Primary prevention population of participants with hypertension (systolic blood pressure, 130 to 160 mm Hg; diastolic blood pressure, < 110 mm Hg) and poor sleep quality in a community setting. Intervention: Multicomponent online sleep intervention consisting of sleep information, sleep hygiene education, and cognitive behavioral therapy. Comparator: Standardized cardiovascular risk factor and lifestyle-education session (usual care). Primary outcome: Change in mean 24-hour ambulatory systolic blood pressure between baseline and 8-week follow-up. Hypertension has been selected as the primary outcome measure because of its robust association with both poor sleep quality and cardiovascular disease. Statistical analyses: Intention-to-treat analysis by using a linear mixed model. C1 [McGrath, Emer R.; Newell, John; Power, Alice; Madden, Sarah; O'Donnell, Martin J.] Natl Univ Ireland, HRB Clin Res Facil, Galway, Ireland. [McGrath, Emer R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Espie, Colin A.] Univ Oxford, Oxford, England. [Murphy, Andrew W.; Byrne, Molly] Natl Univ Ireland, Galway, Ireland. RP McGrath, ER (reprint author), Natl Univ Ireland, HRB Clin Res Facil, Galway, Ireland. EM emcgrath2@partners.org OI O'Donnell, Martin/0000-0002-7347-7761; McGrath, Emer/0000-0002-3589-2964; Newell, John/0000-0001-7685-6655 FU Health Research Board of Ireland (Health Research Award) [HRA_POR/2012/126] FX This trial is directly funded by the Health Research Board of Ireland (Health Research Award, reference HRA_POR/2012/126). The Health Research Board had no role in the design of the study, in the writing of the manuscript, or in the decision to submit the manuscript for publication. NR 34 TC 2 Z9 2 U1 3 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1745-6215 J9 TRIALS JI Trials PD OCT 11 PY 2014 VL 15 AR 393 DI 10.1186/1745-6215-15-393 PG 11 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA AT1PJ UT WOS:000344705600001 PM 25300874 ER PT J AU Bidlack, FB Huynh, C Marshman, J Goetze, B AF Bidlack, Felicitas B. Huynh, Chuong Marshman, Jeffrey Goetze, Bernhard TI Helium ion microscopy of enamel crystallites and extracellular tooth enamel matrix SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE tooth enamel; matrix organization; amelogenin; immuno-gold labeling; helium ion microscopy; high-resolution microscopy ID IN-VITRO; BOVINE ENAMEL; AMELOGENIN; PROTEINS; SURFACES; PH; MINERALIZATION; ORGANIZATION; BIOCHEMISTRY; AMELOBLASTS AB An unresolved problem in tooth enamel studies has been to analyze simultaneously and with sufficient spatial resolution both mineral and organic phases in their three dimensional (3D) organization in a given specimen. This study aims to address this need using high-resolution imaging to analyze the 3D structural organization of the enamel matrix, especially amelogenin, in relation to forming enamel crystals. Chemically fixed hemi-mandibles from wild type mice were embedded in LR White acrylic resin, polished and briefly etched to expose the organic matrix in developing tooth enamel. Full-length amelogenin was labeled with specific antibodies and 10 nm immuno-gold. This allowed us to use and compare two different high-resolution imaging techniques for the analysis of uncoated samples. Helium ion microscopy (HIM) was applied to study the spatial organization of organic and mineral structures, while field emission scanning electron microscopy (FE-SEM) in various modes, including backscattered electron detection, allowed us to discern the gold-labeled proteins. Wild type enamel in late secretory to early maturation stage reveals adjacent to ameloblasts a lengthwise parallel alignment of the enamel matrix proteins, including full-length amelogenin proteins, which then transitions into a more heterogeneous appearance with increasing distance from the mineralization front. The matrix adjacent to crystal bundles forms a smooth and lacey sheath, whereas between enamel prisms it is organized into spherical components that are interspersed with rod-shaped protein. These findings highlight first, that the heterogeneous organization of the enamel matrix can be visualized in mineralized en bloc samples. Second, our results illustrate that the combination of these techniques is a powerful approach to elucidate the 3D structural organization of organic matrix molecules in mineralizing tissue in nanometer resolution. C1 [Bidlack, Felicitas B.] Forsyth Inst, Dept Mineralized Tissue Biol, Cambridge, MA 02142 USA. [Bidlack, Felicitas B.] Harvard Univ, Sch Dent Med, Dept Dev Biol, Boston, MA 02115 USA. [Huynh, Chuong; Marshman, Jeffrey; Goetze, Bernhard] Carl Zeiss Microscopy LLC, Peabody, MA USA. RP Bidlack, FB (reprint author), Forsyth Inst, Dept Mineralized Tissue Biol, 245 First St, Cambridge, MA 02142 USA. EM fbidlack@forsyth.org FU NIH [1R03DE021765-01A1] FX We are grateful for insightful discussions and great departmental support provided by Drs. John D. Bartlett and Megan Pugach. This work was funded by NIH grant 1R03DE021765-01A1. NR 42 TC 1 Z9 1 U1 2 U2 10 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD OCT 10 PY 2014 VL 5 AR 395 DI 10.3389/fphys.2014.00395 PG 10 WC Physiology SC Physiology GA AX7XC UT WOS:000347124100001 PM 25346697 ER PT J AU Sherman, ME Piedmonte, M Mai, PL Ioffe, OB Ronnett, BM Van Le, L Ivanov, I Bell, MC Blank, SV DiSilvestro, P Hamilton, CA Tewari, KS Wakeley, K Kauff, ND Yamada, SD Rodriguez, G Skates, SJ Alberts, DS Walker, JL Minasian, L Lu, K Greene, MH AF Sherman, Mark E. Piedmonte, Marion Mai, Phuong L. Ioffe, Olga B. Ronnett, Brigitte M. Van Le, Linda Ivanov, Iouri Bell, Maria C. Blank, Stephanie V. DiSilvestro, Paul Hamilton, Chad A. Tewari, Krishnansu S. Wakeley, Katie Kauff, Noah D. Yamada, S. Diane Rodriguez, Gustavo Skates, Steven J. Alberts, David S. Walker, Joan L. Minasian, Lori Lu, Karen Greene, Mark H. TI Pathologic Findings at Risk-Reducing Salpingo-Oophorectomy: Primary Results From Gynecologic Oncology Group Trial GOG-0199 SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID BRCA MUTATION CARRIERS; EPITHELIAL OVARIAN-CANCER; UTERINE SEROUS CARCINOMA; HEREDITARY HIGH-RISK; GERM-LINE MUTATION; FALLOPIAN-TUBE; PROPHYLACTIC OOPHORECTOMY; ORAL-CONTRACEPTIVES; WOMEN; BREAST AB Purpose Risk-reducing salpingo-oophorectomy (RRSO) lowers mortality from ovarian/tubal and breast cancers among BRCA1/2 mutation carriers. Uncertainties persist regarding potential benefits of RRSO among high-risk noncarriers, optimal surgical age, and anatomic origin of clinically occult cancers detected at surgery. To address these topics, we analyzed surgical treatment arm results from Gynecologic Oncology Group Protocol-0199 (GOG-0199), the National Ovarian Cancer Prevention and Early Detection Study. Participants and Methods This analysis included asymptomatic high-risk women age >= 30 years who elected RRSO at enrollment. Women provided risk factor data and underwent preoperative cancer antigen 125 (CA-125) serum testing and transvaginal ultrasound (TVU). RRSO specimens were processed according to a standardized tissue processing protocol and underwent central pathology panel review. Research-based BRCA1/2 mutation testing was performed when a participant's mutation status was unknown at enrollment. Relationships between participant characteristics and diagnostic findings were assessed using univariable statistics and multivariable logistic regression. Results Invasive or intraepithelial ovarian/tubal/peritoneal neoplasms were detected in 25 (2.6%) of 966 RRSOs (BRCA1 mutation carriers, 4.6%; BRCA2 carriers, 3.5%; and noncarriers, 0.5%; P < .001). In multivariable models, positive BRCA1/2 mutation status (P = .0056), postmenopausal status (P = .0023), and abnormal CA-125 levels and/or TVU examinations (P < .001) were associated with detection of clinically occult neoplasms at RRSO. For 387 women with negative BRCA1/2 mutation testing and normal CA-125 levels, findings at RRSO were benign. Conclusion Clinically occult cancer was detected among 2.6% of high-risk women undergoing RRSO. BRCA1/2 mutation, postmenopausal status, and abnormal preoperative CA-125 and/or TVU were associated with cancer detection at RRSO. These data can inform management decisions among women at high risk of ovarian/tubal cancer. (C) 2014 by American Society of Clinical Oncology C1 [Sherman, Mark E.; Mai, Phuong L.; Minasian, Lori; Greene, Mark H.] NCI, Rockville, MD 20850 USA. [Ioffe, Olga B.] Univ Maryland, Med Ctr, Baltimore, MD 21201 USA. [Ronnett, Brigitte M.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. [Hamilton, Chad A.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Piedmonte, Marion] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Blank, Stephanie V.] NYU, Sch Med, New York, NY USA. [Kauff, Noah D.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Van Le, Linda] Univ N Carolina, Chapel Hill, NC USA. [Ivanov, Iouri] Columbus Canc Council, Columbus, OH USA. [Bell, Maria C.] Sanford Univ, South Dakota Med Ctr, Sioux Falls, SD USA. [DiSilvestro, Paul] Brown Univ, Women & Infants Hosp, Providence, RI USA. [Tewari, Krishnansu S.] Univ Calif Med Ctr Irvine, Orange, CA USA. [Wakeley, Katie] Tufts Univ, Boston, MA 02111 USA. [Skates, Steven J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Yamada, S. Diane] Univ Chicago, Chicago, IL 60637 USA. [Rodriguez, Gustavo] North Shore Univ Hlth Syst, Evanston, IL USA. [Alberts, David S.] Univ Arizona, Ctr Canc, Tucson, AZ USA. [Walker, Joan L.] Univ Oklahoma, Oklahoma City, OK USA. [Lu, Karen] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA. RP Greene, MH (reprint author), NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, 9609 Med Ctr Dr,Room 6E-454, Rockville, MD 20850 USA. EM greenem@mail.nih.gov OI Kauff, Noah/0000-0001-7242-6156 FU Intramural NIH HHS; NCATS NIH HHS [UL1 TR000430]; NCI NIH HHS [UG1 CA189867, U10 CA037517, U10 CA101165, P30 CA016672, U01 CA152990, U10 CA180822, CA 37517, U10 CA180838, U10 CA027469, CA 27469, CA101165] NR 71 TC 21 Z9 21 U1 1 U2 7 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD OCT 10 PY 2014 VL 32 IS 29 BP 3275 EP + DI 10.1200/JCO.2013.54.1987 PG 10 WC Oncology SC Oncology GA AQ7JC UT WOS:000342988000012 PM 25199754 ER PT J AU Chawla, SP Cranmer, LD Van Tine, BA Reed, DR Okuno, SH Butrynski, JE Adkins, DR Hendifar, AE Kroll, S Ganjoo, KN AF Chawla, Sant P. Cranmer, Lee D. Van Tine, Brian A. Reed, Damon R. Okuno, Scott H. Butrynski, James E. Adkins, Douglas R. Hendifar, Andrew E. Kroll, Stew Ganjoo, Kristen N. TI Phase II Study of the Safety and Antitumor Activity of the Hypoxia-Activated Prodrug TH-302 in Combination With Doxorubicin in Patients With Advanced Soft Tissue Sarcoma SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID TUMOR HYPOXIA; EUROPEAN-ORGANIZATION; PROGNOSTIC-FACTORS; SOLID TUMORS; CANCER; PHARMACOKINETICS; CHEMOTHERAPY; IFOSFAMIDE; CELLS; EXPRESSION AB Purpose TH-302, a prodrug of the cytotoxic alkylating agent bromo-isophosphoramide mustard, is preferentially activated in hypoxic conditions. This phase II study investigated TH-302 in combination with doxorubicin, followed by single-agent TH-302 maintenance therapy in patients with first-line advanced soft tissue sarcoma (STS) to assess progression-free survival (PFS), response rate, overall survival, safety, and tolerability. Patients and Methods In this open-label phase II study, TH-302 300 mg/m(2) was administered intravenously on days 1 and 8 with doxorubicin 75 mg/m(2) on day 1 of each 21-day cycle. After six cycles, patients with stable and/or responding disease could receive maintenance monotherapy with TH-302. Results Ninety-one patients initiated TH-302 plus doxorubicin induction treatment. The PFS rate at 6 months (primary efficacy measure) was 58% (95% Cl, 46% to 68%). Median PFS was 6.5 months (95% Cl, 5.8 to 7.7 months); median overall survival was 21.5 months (95% Cl, 16.0 to 26.2 months). Best tumor responses were complete response (n = 2 [2%]) and partial response (n = 30 [34%]). During TH-302 maintenance (n = 48), five patients improved from stable disease to partial response, and one patient improved from partial to complete response. The most common adverse events during induction were fatigue, nausea, and skin and/or mucosal toxicities as well as anemia, thrombocytopenia, and neutropenia. These were less severe and less frequent during maintenance. There was no evidence of TH-302-related hepatic, renal, or cardiac toxicity. Conclusion PFS, overall survival, and tumor response compared favorably with historical outcomes achieved with other first-line chemotherapies for advanced STS. A phase lll study of TH-302 is ongoing (NCT01440088). (C) 2014 by American Society of Clinical Oncology C1 [Chawla, Sant P.] Sarcoma Oncol Ctr, Santa Monica, CA 90403 USA. [Hendifar, Andrew E.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Kroll, Stew] Threshold Pharmaceut, San Francisco, CA USA. [Ganjoo, Kristen N.] Stanford Univ, Med Ctr, Stanford, CA 94305 USA. [Cranmer, Lee D.] Univ Arizona, Ctr Canc, Tucson, AZ USA. [Van Tine, Brian A.; Adkins, Douglas R.] Washington Univ, St Louis, MO USA. [Reed, Damon R.] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. [Okuno, Scott H.] Mayo Clin, Rochester, MN USA. [Butrynski, James E.] Dana Farber Canc Inst, Boston, MA 02115 USA. RP Chawla, SP (reprint author), Sarcoma Oncol Ctr, 2811 Wilshire Blvd,Suite 414, Santa Monica, CA 90403 USA. EM santchawla@sarcomaoncology.com FU Threshold Pharmaceuticals, South San Francisco, CA; Merck KGaA, Darmstadt, Germany; Scientific Connections, Threshold Pharmaceuticals, and Merck KGaA FX Supported by Threshold Pharmaceuticals, South San Francisco, CA, and Merck KGaA, Darmstadt, Germany. Editorial assistance and submission were supported by Scientific Connections, Threshold Pharmaceuticals, and Merck KGaA. NR 30 TC 39 Z9 39 U1 0 U2 9 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD OCT 10 PY 2014 VL 32 IS 29 BP 3299 EP + DI 10.1200/JCO.2013.54.3660 PG 11 WC Oncology SC Oncology GA AQ7JC UT WOS:000342988000015 PM 25185097 ER PT J AU Partridge, AH Rumble, RB Carey, LA Come, SE Davidson, NE Di Leo, A Gralow, J Hortobagyi, GN Moy, B Yee, D Brundage, SB Danso, MA Wilcox, M Smith, IE AF Partridge, Ann H. Rumble, R. Bryan Carey, Lisa A. Come, Steven E. Davidson, Nancy E. Di Leo, Angelo Gralow, Julie Hortobagyi, Gabriel N. Moy, Beverly Yee, Douglas Brundage, Shelley B. Danso, Michael A. Wilcox, Maggie Smith, Ian E. TI Chemotherapy and Targeted Therapy for Women With Human Epidermal Growth Factor Receptor 2-Negative (or unknown) Advanced Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID PHASE-III TRIAL; CAPECITABINE PLUS DOCETAXEL; ANTHRACYCLINE-PRETREATED PATIENTS; PEGYLATED LIPOSOMAL DOXORUBICIN; FRONT-LINE CHEMOTHERAPY; 1ST-LINE TREATMENT; RANDOMIZED-TRIAL; OPEN-LABEL; NAB-PACLITAXEL; FINAL ANALYSIS AB Purpose To identify optimal chemo-and targeted therapy for women with human epidermal growth factor 2 (HER2)-negative (or unknown) advanced breast cancer. Methods A systematic review of randomized evidence (including systematic reviews and meta-analyses) from 1993 through to current was completed. Outcomes of interest included survival, progressionfree survival, response, quality of life, and adverse effects. Guideline recommendations were evidence based and were agreed on by the Expert Panel via consensus. Results Seventy-nine studies met the inclusion criteria, comprising 20 systematic reviews and/or metaanalyses, 30 trials on first-line treatment, and 29 trials on second-line and subsequent treatment. These trials form the evidence base for the guideline recommendations. Recommendations Endocrine therapy is preferable to chemotherapy as first-line treatment for patients with estrogen receptor-positive metastatic breast cancer unless improvement is medically necessary (eg, immediately life-threatening disease). Single agent is preferable to combination chemotherapy, and longer planned duration improves outcome but must be balanced against toxicity. There is no single optimal first-line or subsequent line chemotherapy, and choice of treatment will be determined by multiple factors including prior therapy, toxicity, performance status, comorbid conditions, and patient preference. The role of bevacizumab remains controversial. Other targeted therapies have not so far been shown to enhance chemotherapy outcome in HER2-negative breast cancer. (C) 2014 by American Society of Clinical Oncology C1 [Partridge, Ann H.] Dana Farber Canc Inst, Boston, MA USA. [Come, Steven E.] Beth Israel Deaconess Med Ctr, Boston, MA USA. [Moy, Beverly] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Rumble, R. Bryan] Amer Soc Clin Oncol, Alexandria, VA 22314 USA. [Danso, Michael A.] Virginia Oncol Associates, Norfolk, VA USA. [Carey, Lisa A.] Univ N Carolina, Chapel Hill, NC USA. [Davidson, Nancy E.] Univ Pittsburgh, Med Ctr, Inst Canc, Pittsburgh, PA USA. [Di Leo, Angelo] Sandro Pitigliani Med Oncol Unit, Prato, Italy. [Gralow, Julie] Univ Washington, Seattle Canc Care Alliance, Seattle, WA 98195 USA. [Hortobagyi, Gabriel N.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Yee, Douglas] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA. [Smith, Ian E.] Royal Marsden Hosp, London SW3 6JJ, England. RP Partridge, AH (reprint author), Amer Soc Clin Oncol, 2318 Mill Rd,Suite 800, Alexandria, VA 22314 USA. EM guidelines@asco.org NR 97 TC 58 Z9 64 U1 0 U2 7 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD OCT 10 PY 2014 VL 32 IS 29 BP 3307 EP + DI 10.1200/JCO.2014.56.7479 PG 25 WC Oncology SC Oncology GA AQ7JC UT WOS:000342988000016 PM 25185096 ER PT J AU Partridge, AH Seah, DSE King, T Leighl, NB Hauke, R Wollins, DS Von Roenn, JH AF Partridge, Ann H. Seah, Davinia S. E. King, Tari Leighl, Natasha B. Hauke, Ralph Wollins, Dana S. Von Roenn, Jamie Hayden TI Developing a Service Model That Integrates Palliative Care Throughout Cancer Care: The Time Is Now SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; CLINICAL-TRIALS; AMERICAN SOCIETY; SUPPORTIVE CARE; ONCOLOGY; COST; MEDICINE; OUTCOMES; HOSPICE AB Palliative care is a fundamental component of cancer care. As part of the 2011 to 2012 Leadership Development Program (LDP) of the American Society of Clinical Oncology (ASCO), a group of participants was charged with advising ASCO on how to develop a service model integrating palliative care throughout the continuum of cancer care. This article presents the findings of the LDP group. The group focused on the process of palliative care delivery in the oncology setting. We identified key elements for models of palliative care in various settings to be potentially equitable, sustainable, feasible, and acceptable, and here we describe a dynamic model for the integrated, simultaneous implementation of palliative care into oncology practice. We also discuss critical considerations to better integrate palliative care into oncology, including raising consciousness and educating both providers and the public about the importance of palliative care; coordinating palliative care efforts through strengthening affiliations and/or developing new partnerships; prospectively evaluating the impact of palliative care on patient and provider satisfaction, quality improvement, and cost savings; and ensuring sustainability through adequate reimbursement and incentives, including linkage of performance data to quality indicators, and coordination with training efforts and maintenance of certification requirements for providers. In light of these findings, we believe the confluence of increasing importance of incorporation of palliative care education in oncology education, emphasis on value-based care, growing use of technology, and potential cost savings makes developing and incorporating palliative care into current service models a meaningful goal. (C) 2014 by American Society of Clinical Oncology C1 [Partridge, Ann H.; Seah, Davinia S. E.] Dana Farber Canc Inst, Boston, MA 02215 USA. [King, Tari] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Leighl, Natasha B.] Princess Margaret Canc Ctr, Toronto, ON, Canada. [Hauke, Ralph] Nebraska Canc Specialists, Omaha, NE USA. [Wollins, Dana S.] Amer Soc Clin Oncol, Alexandria, VA USA. [Von Roenn, Jamie Hayden] Northwestern Univ, Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. RP Partridge, AH (reprint author), Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA. EM ahpartridge@partners.org NR 61 TC 21 Z9 21 U1 4 U2 12 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD OCT 10 PY 2014 VL 32 IS 29 BP 3330 EP 3336 DI 10.1200/JCO.2013.54.8149 PG 7 WC Oncology SC Oncology GA AQ7JC UT WOS:000342988000017 PM 25199756 ER PT J AU Wood, ME Lu, KH Wollins, DS Hughes, KS AF Wood, Marie E. Lu, Karen H. Wollins, Dana S. Hughes, Kevin S. TI Important Differences Between a Triage Pedigree and Risk Assessment Reply to AS Sie et al, K. Hemminki et al, and J. Larsen Haidle SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Letter ID CANCER FAMILY-HISTORY; AMERICAN SOCIETY; ONCOLOGY PRACTICES; COLLECTION; MUTATIONS C1 [Wood, Marie E.] Univ Vermont, Burlington, VT 05405 USA. [Lu, Karen H.] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA. [Wollins, Dana S.] Amer Soc Clin Oncol, Alexandria, VA USA. [Hughes, Kevin S.] Mass Gen Hosp, Avon Comprehens Breast Evaluat Ctr, Boston, MA USA. RP Wood, ME (reprint author), Univ Vermont, Burlington, VT 05405 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD OCT 10 PY 2014 VL 32 IS 29 BP 3346 EP + DI 10.1200/JCO.2014.56.8535 PG 2 WC Oncology SC Oncology GA AQ7JC UT WOS:000342988000027 PM 25185101 ER PT J AU Wilmer, JB Germine, LT Nakayama, K AF Wilmer, Jeremy B. Germine, Laura T. Nakayama, Ken TI Face recognition: a model specific ability SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Review DE specific ability; individual differences; face recognition; intelligence; IQ; multiple intelligences; cambridge face memory test; generalist gene ID INDIVIDUAL-DIFFERENCES; SOCIAL INTELLIGENCE; OBJECT RECOGNITION; MEMORY TEST; PERCEPTION; COGNITION; PERFORMANCE; AREA; SEX AB In our everyday lives, we view it as a matter of course that different people are good at different things. It can be surprising, in this context, to learn that most of what is known about cognitive ability variation across individuals concerns the broadest of all cognitive abilities; an ability referred to as general intelligence, general mental ability, or just g. In contrast, our knowledge of specific abilities, those that correlate little with g, is severely constrained. Here, we draw upon our experience investigating an exceptionally specific ability, face recognition, to make the case that many specific abilities could easily have been missed. In making this case, we derive key insights from earlier false starts in the measurement of face recognition's variation across individuals, and we highlight the convergence of factors that enabled the recent discovery that this variation is specific. We propose that the case of face recognition ability illustrates a set of tools and perspectives that could accelerate fruitful work on specific cognitive abilities. By revealing relatively independent dimensions of human ability, such work would enhance our capacity to understand the uniqueness of individual minds. C1 [Wilmer, Jeremy B.] Wellesley Coll, Dept Psychol, Wellesley, MA 02481 USA. [Germine, Laura T.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA. [Nakayama, Ken] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA. RP Wilmer, JB (reprint author), Wellesley Coll, Dept Psychol, 106 Cent St, Wellesley, MA 02481 USA. EM jwilmer@wellesley.edu OI Germine, Laura/0000-0001-8690-8412 FU Brachman Hoffman Fellowship FX This work was supported by a Brachman Hoffman Fellowship to Jeremy B. Wilmer. NR 48 TC 4 Z9 4 U1 13 U2 38 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD OCT 10 PY 2014 VL 8 AR 769 DI 10.3389/fnhum.2014.00769 PG 5 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA AQ4CY UT WOS:000342741100001 PM 25346673 ER PT J AU Yi, X Yuan, DF Farr, SA Banks, WA Poon, CD Kabanov, AV AF Yi, Xiang Yuan, Dongfen Farr, Susan A. Banks, William A. Poon, Chi-Duen Kabanov, Alexander V. TI Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity SO JOURNAL OF CONTROLLED RELEASE LA English DT Article; Proceedings Paper CT 11th International Nanomedicine and Drug Delivery Symposium (NanoDDS) CY OCT 25-27, 2013 CL San Diego, CA DE Leptin; Pluronic block copolymer; Protein-polymer conjugation; Brain pharmacokinetics; Blood-brain barrier; Obesity ID MODIFIED SUPEROXIDE-DISMUTASE; SECONDARY STRUCTURE ANALYSES; GLYCOL-MODIFIED PROTEINS; RECOMBINANT HUMAN LEPTIN; WEIGHT-LOSS; POLY(ETHYLENE GLYCOL); MONOCLONAL-ANTIBODY; FOOD-INTAKE; PEG-OB; BARRIER AB Modification of hydrophilic proteins with amphiphilic block copolymers capable of crossing cell membranes is a new strategy to improve protein delivery to the brain. Leptin, a candidate for the treatment of epidemic obesity, has failed in part because of impairment in its transport across the blood-brain barrier (BBB) that develops with obesity. We posit that modification of leptin with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly (ethylene oxide), Pluronic P85 (P85) might permit this protein to penetrate the BBB independently of its transporter, thereby overcoming peripheral leptin resistance. Here we report that peripherally administered leptin-P85 conjugates exhibit biological activity by reducing food intake in mouse models of obesity (ob/ob, and diet-induced obese mouse). We further generated two new leptin-P85 conjugates: one, Lep (ss)-P85 (L), containing one P85 chain and another, Lep(ss)-P85(H), containing multiple P85 chains. We report data on their purification, analytical characterization, peripheral and brain pharmacokinetics (PK). Lep(ss)-P85(L) crosses the BBB using the leptin transporter, and exhibits improved peripheral PK along with increased accumulation in the brain compared to unmodified leptin. Lep(ss)-P85(H) also has improved peripheral PK but in a striking difference to the first conjugate penetrates the BBB independently of the leptin transporter via a non-saturable mechanism. The results demonstrate that leptin analogs can be developed through chemical modification of the native leptin with P85 to overcome leptin resistance at the level of the BBB, thus improving the potential for the treatment of obesity. (C) 2014 Elsevier B.V. All rights reserved. C1 [Yi, Xiang; Yuan, Dongfen; Kabanov, Alexander V.] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA. [Yi, Xiang; Yuan, Dongfen; Kabanov, Alexander V.] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA. [Farr, Susan A.] St Louis Univ, Res & Dev, VA Med Ctr, Sch Med, St Louis, MI USA. [Farr, Susan A.] St Louis Univ, Div Geriatr, Sch Med, St Louis, MI USA. [Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA 98108 USA. [Banks, William A.] Univ Washington, Div Gerontol & Geriatr Med, Dept Med, Sch Med, Seattle, WA 98108 USA. [Poon, Chi-Duen] Univ N Carolina, Ctr Res Comp, Chapel Hill, NC 27599 USA. [Kabanov, Alexander V.] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119899, Russia. RP Yi, X (reprint author), Univ N Carolina, Ctr Nanotechnol Drug Delivery, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA. EM xiang_yi@unc.edu; kabanov@unc.edu FU NCI NIH HHS [CA016086, P30 CA016086]; NINDS NIH HHS [R01 NS051334] NR 56 TC 10 Z9 11 U1 1 U2 28 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-3659 EI 1873-4995 J9 J CONTROL RELEASE JI J. Control. Release PD OCT 10 PY 2014 VL 191 SI SI BP 34 EP 46 DI 10.1016/j.jconrel.2014.05.044 PG 13 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA AP7SA UT WOS:000342275800005 PM 24881856 ER PT J AU Petrich, AM Gandhi, M Jovanovic, B Castillo, JJ Rajguru, S Yang, DT Shah, KA Whyman, JD Lansigan, F Hernandez-Ilizaliturri, FJ Lee, LX Barta, SK Melinamani, S Karmali, R Adeimy, C Smith, S Dalal, N Nabhan, C Peace, D Vose, J Evens, AM Shah, N Fenske, TS Zelenetz, AD Landsburg, DJ Howlett, C Mato, A Jaglal, M Chavez, JC Tsai, JP Reddy, N Li, S Handler, C Flowers, CR Cohen, JB Blum, KA Song, K Sun, HL Press, O Cassaday, R Jaso, J Medeiros, LJ Sohani, AR Abramson, JS AF Petrich, Adam M. Gandhi, Mitul Jovanovic, Borko Castillo, Jorge J. Rajguru, Saurabh Yang, David T. Shah, Khushboo A. Whyman, Jeremy D. Lansigan, Frederick Hernandez-Ilizaliturri, Francisco J. Lee, Lisa X. Barta, Stefan K. Melinamani, Shruthi Karmali, Reem Adeimy, Camille Smith, Scott Dalal, Neil Nabhan, Chadi Peace, David Vose, Julie Evens, Andrew M. Shah, Namrata Fenske, Timothy S. Zelenetz, Andrew D. Landsburg, Daniel J. Howlett, Christina Mato, Anthony Jaglal, Michael Chavez, Julio C. Tsai, Judy P. Reddy, Nishitha Li, Shaoying Handler, Caitlin Flowers, Christopher R. Cohen, Jonathon B. Blum, Kristie A. Song, Kevin Sun, Haowei (Linda) Press, Oliver Cassaday, Ryan Jaso, Jesse Medeiros, L. Jeffrey Sohani, Aliyah R. Abramson, Jeremy S. TI Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis SO BLOOD LA English DT Article ID NON-HODGKINS-LYMPHOMA; GERMINAL CENTER; POOR-PROGNOSIS; PHASE-II; RITUXIMAB; MYC; SURVIVAL; INDEX; CHOP; TRANSLOCATION AB Patients with double-hit lymphoma (DHL), which is characterized by rearrangements of MYC and either BCL2 or BCL6, face poor prognoses. We conducted a retrospective multicenter study of the impact of baseline clinical factors, induction therapy, and stem cell transplant (SCT) on the outcomes of 311 patients with previously untreated DHL. At median follow-up of 23 months, the median progression-free survival (PFS) and overall survival (OS) rates among all patients were 10.9 and 21.9 months, respectively. Forty percent of patients remain disease-free and 49% remain alive at 2 years. Intensive induction was associated with improved PFS, but not OS, and SCT was not associated with improved OS among patients achieving first complete remission (P = .14). By multivariate analysis, advanced stage, central nervous system involvement, leukocytosis, and LDH>3 times the upper limit of normal were associated with higher risk of death. Correcting for these, intensive induction was associated with improved OS. We developed a novel risk score for DHL, which divides patients into high-, intermediate-, and low-risk groups. In conclusion, a subset of DHL patients may be cured, and some patients may benefit from intensive induction. Further investigations into the roles of SCT and novel agents are needed. C1 [Petrich, Adam M.; Gandhi, Mitul; Jovanovic, Borko] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. [Castillo, Jorge J.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Rajguru, Saurabh] Univ Wisconsin, Div Hematol Oncol, Madison, WI USA. [Yang, David T.] Univ Wisconsin, Dept Pathol, Madison, WI 53706 USA. [Yang, David T.] Univ Wisconsin, Lab Med, Madison, WI USA. [Shah, Khushboo A.; Whyman, Jeremy D.; Lansigan, Frederick] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Hernandez-Ilizaliturri, Francisco J.] Roswell Pk Canc Inst, Dept Immunol & Med, Buffalo, NY 14263 USA. [Lee, Lisa X.; Barta, Stefan K.] Montefiore Med Ctr, Albert Einstein Canc Ctr, Dept Oncol, Bronx, NY 10467 USA. [Melinamani, Shruthi; Karmali, Reem] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Adeimy, Camille; Smith, Scott] Loyola Univ, Med Ctr, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA. [Dalal, Neil] Advocate Lutheran Gen Hosp, Div Hematol Oncol, Park Ridge, IL USA. [Nabhan, Chadi; Peace, David] Univ Chicago, Dept Med, Sect Hematol & Oncol, Chicago, IL 60637 USA. [Vose, Julie] Univ Nebraska, Med Ctr, Omaha, NE USA. [Evens, Andrew M.] Tufts Med Ctr, Div Hematology Oncol, Boston, MA USA. [Evens, Andrew M.] Tufts Univ, Sch Med, Boston, MA 02111 USA. [Shah, Namrata; Fenske, Timothy S.] Med Coll Wisconsin, Div Hematol & Oncol, Milwaukee, WI 53226 USA. [Zelenetz, Andrew D.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA. [Landsburg, Daniel J.; Mato, Anthony] Hosp Univ Penn, Div Hematol Oncol, Philadelphia, PA 19104 USA. [Howlett, Christina; Mato, Anthony] Hackensack Univ, Med Ctr, Div Hematol Oncol, Hackensack, NJ USA. [Howlett, Christina] Rutgers State Univ, Ernest Mario Sch Pharm, Piscataway, NJ USA. [Jaglal, Michael; Chavez, Julio C.] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA. [Tsai, Judy P.; Reddy, Nishitha] Vanderbilt Univ, Med Ctr, Div Hematol Oncol, Nashville, TN USA. [Li, Shaoying] Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN USA. [Handler, Caitlin; Flowers, Christopher R.; Cohen, Jonathon B.] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA. [Cohen, Jonathon B.; Blum, Kristie A.] Ohio State Univ, James Comprehens Canc Ctr, Div Hematol, Columbus, OH 43210 USA. [Song, Kevin; Sun, Haowei (Linda)] British Columbia Canc Agcy, Leukemia BMT Program British Columbia, Vancouver, BC V5Z 4E6, Canada. [Press, Oliver; Cassaday, Ryan] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA. [Jaso, Jesse; Medeiros, L. Jeffrey] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA. [Sohani, Aliyah R.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Abramson, Jeremy S.] Massachusetts Gen Hosp, Ctr Canc, Ctr Lymphoma, Boston, MA 02114 USA. RP Petrich, AM (reprint author), Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. RI Flowers, Christopher/F-1953-2010; OI Flowers, Christopher/0000-0002-9524-3990; Jaglal, Michael/0000-0002-4305-2535; Castillo, Jorge/0000-0001-9490-7532 FU Millennium; Seattle Genetics; Celgene; Spectrum Pharmaceuticals; Janssen; GlaxoSmithKline; Otsuka; Genentech; Acerta; Infinity; Onyx; Janssen Oncology; Gilead Sciences; Spectrum; Bristol Meyers Squibb; Roche FX Conflict-of-interest disclosure: A.M.P. is a consultant for and receives honoraria from Celgene, Spectrum Pharmaceuticals, Genentech, Seattle Genetics, and Janssen, and receives research funding from Millennium, Seattle Genetics, Celgene, Spectrum Pharmaceuticals, and Janssen. J.J.C. is a consultant for Otsuka and receives research funding from GlaxoSmithKline, and Millennium. S.K.B. is a consultant for Seattle Genetics and Onyx; is on the speakers' bureau for Onyx, Celgene, and Pharmacyclics; and has research funding from Otsuka. C.N. is a consultant for Genentech, Celgene, Janssen Oncology, and Medivation; is on the speakers' bureau for Celgene, GlaxoSmithKline, Dendreon, Genentech, and Janssen Oncology; and receives research funding from Celgene and Genentech. D.P. is a consultant for Seattle Genetics and Algeta; has patents, royalties, or other intellectual property with the University of Illinois at Chicago; and reports travel and other expenses from Algeta. N.R. is a consultant for Immunogen and Celgene and has research funding from Celgene. C.R.F. is a consultant for OptumRx, Algeta, and Seattle Genetics and receives research funding from Acerta, Infinity, Onyx, Janssen Oncology, Gilead Sciences, Spectrum, and Celgene. J.B.C. is a consultant for Seattle Genetics and Pharmacyclics and receives research support from Bristol Meyers Squibb and Janssen. K.S. receives research funding from Roche. A.R.S. has received honoraria from Seattle Genetics and has provided expert testimony to Western Litigation. The remaining authors declare no competing financial interests. NR 34 TC 73 Z9 77 U1 2 U2 6 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD OCT 9 PY 2014 VL 124 IS 15 BP 2354 EP 2361 DI 10.1182/blood-2014-05-578963 PG 8 WC Hematology SC Hematology GA AY2ZL UT WOS:000347454400013 PM 25161267 ER PT J AU Walker, RJ Gebregziabher, M Martin-Harris, B Egede, LE AF Walker, Rebekah J. Gebregziabher, Mulugeta Martin-Harris, Bonnie Egede, Leonard E. TI Relationship between social determinants of health and processes and outcomes in adults with type 2 diabetes: validation of a conceptual framework SO BMC ENDOCRINE DISORDERS LA English DT Article DE Diabetes; Social determinants; Socioeconomic; Psychological; Glycemic control; Conceptual framework ID GLYCEMIC CONTROL; SELF-CARE; PSYCHOMETRIC PROPERTIES; SOCIOECONOMIC POSITION; SCALE; METAANALYSIS; VALIDITY; SUPPORT; QUESTIONNAIRE; DEPRESSION AB Background: The aim of this study was to empirically validate a conceptual framework and elucidate the pathways linking social determinants of health to outcomes in individuals with type 2 diabetes. Methods: 615 adults were recruited from adult primary care clinics in the southeastern United States. The model was estimated using path analysis to determine if socioeconomic (education, employment, income) and psychosocial (fatalism, self-efficacy, depression, diabetes distress, serious psychological distress, social support, and perceived stress) factors would independently predict glycemic control or be associated with mediator/moderators of self-care, access to care, and processes of care. Covariates were gender, age, race and health literacy. Results: The final model (chi2 (15) = 17.68, p = 0.28; RMSEA = 0.02, CFI = 0.99) showed lower glycemic control was directly associated with less hours worked (r = 0.13, p = 0.002), more fatalistic attitudes (r = -0.09, p = 0.03), more self-efficacy (r = -0.30, p < 0.001), and less diabetes distress (r = 0.12, p = 0.03), with the majority of total effects being direct. Significant paths associated self-care with diabetes distress (r = -0.14, p = 0.01) and perceived stress (r = -0.15, p = .001); access to care with income (r = 0.08, p = 0.03), diabetes distress (r = -0.21, p < 0.001) and social support (r = 0.08, p = 0.03); and processes of care with income (r = -0.11, p = 0.03), social support (r = 0.10, p = 0.04), and perceived stress (r = 0.10, p = 0.04). The paths explained 76% of the variance in the model. Conclusions: Consistent with the conceptual framework, social determinants were associated with glycemic control through a direct association and mediators/moderators of self-care, access to care and processes of care. This study provides the first validation of a conceptual framework for the relationship between socioeconomic and psychological components of social determinants of health and diabetes outcomes. C1 [Walker, Rebekah J.; Gebregziabher, Mulugeta; Egede, Leonard E.] Ralph H Johnson VAMC, Charleston VA HSR&D COIN, Hlth Equ & Rural Outreach Innovat Ctr HEROIC, Charleston, SC 29401 USA. [Walker, Rebekah J.; Egede, Leonard E.] Med Univ S Carolina, Ctr Hlth Dispar Res, Charleston, SC 29425 USA. [Walker, Rebekah J.; Martin-Harris, Bonnie] Med Univ S Carolina, Dept Hlth Sci & Res, Charleston, SC 29425 USA. [Gebregziabher, Mulugeta] Med Univ S Carolina, Dept Med, Div Publ Hlth Sci, Charleston, SC 29425 USA. [Martin-Harris, Bonnie] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA. [Egede, Leonard E.] Med Univ S Carolina, Dept Med, Div Gen Internal Med & Geriatr, Charleston, SC 29425 USA. RP Egede, LE (reprint author), Ralph H Johnson VAMC, Charleston VA HSR&D COIN, Hlth Equ & Rural Outreach Innovat Ctr HEROIC, Charleston, SC 29401 USA. EM egedel@musc.edu OI Gebregziabher, Mulugeta/0000-0002-4826-481X FU National Institute of Diabetes and Digestive and Kidney Disease [K24DK093699-01] FX This study was supported by Grant K24DK093699-01 from The National Institute of Diabetes and Digestive and Kidney Disease (PI: Leonard Egede). NR 45 TC 6 Z9 6 U1 5 U2 19 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6823 J9 BMC ENDOCR DISORD JI BMC Endocr. Disord. PD OCT 9 PY 2014 VL 14 AR 82 DI 10.1186/1472-6823-14-82 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AT1PD UT WOS:000344705000001 PM 25298071 ER PT J AU Roccaro, AM Sacco, A Purschke, WG Moschetta, M Buchner, K Maasch, C Zboralski, D Zollner, S Vonhoff, S Mishima, Y Maiso, P Reagan, MR Lonardi, S Ungari, M Facchetti, F Eulberg, D Kruschinski, A Vater, A Rossi, G Klussmann, S Ghobrial, IM AF Roccaro, Aldo M. Sacco, Antonio Purschke, Werner G. Moschetta, Michele Buchner, Klaus Maasch, Christian Zboralski, Dirk Zoellner, Stefan Vonhoff, Stefan Mishima, Yuji Maiso, Patricia Reagan, Michaela R. Lonardi, Silvia Ungari, Marco Facchetti, Fabio Eulberg, Dirk Kruschinski, Anna Vater, Axel Rossi, Giuseppe Klussmann, Sven Ghobrial, Irene M. TI SDF-1 Inhibition Targets the Bone Marrow Niche for Cancer Therapy SO CELL REPORTS LA English DT Article ID HEMATOPOIETIC PROGENITOR CELLS; MULTIPLE-MYELOMA; WALDENSTROM MACROGLOBULINEMIA; BREAST-CANCER; STROMAL CELLS; CD34(+) CELLS; IN-VIVO; METASTASIS; MECHANISMS; MIGRATION AB Bone marrow (BM) metastasis remains one of the main causes of death associated with solid tumors as well as multiple myeloma (MM). Targeting the BM niche to prevent or modulate metastasis has not been successful to date. Here, we show that stromal cell-derived factor-1 (SDF-1/CXCL12) is highly expressed in active MM, as well as in BM sites of tumor metastasis and report on the discovery of the high-affinity anti-SDF-1 PEGylated mirror-image L-oligonucleotide (olaptesed-pegol). In vivo confocal imaging showed that SDF-1 levels are increased within MM cell-colonized BM areas. Using in vivo murine and xenograft mouse models, we document that in vivo SDF-1 neutralization within BM niches leads to a microenvironment that is less receptive for MM cells and reduces MM cell homing and growth, thereby inhibiting MM disease progression. Targeting of SDF-1 represents a valid strategy for preventing or disrupting colonization of the BM by MM cells. C1 [Roccaro, Aldo M.; Sacco, Antonio; Moschetta, Michele; Mishima, Yuji; Maiso, Patricia; Reagan, Michaela R.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. [Purschke, Werner G.; Buchner, Klaus; Maasch, Christian; Zboralski, Dirk; Zoellner, Stefan; Vonhoff, Stefan; Eulberg, Dirk; Kruschinski, Anna; Vater, Axel; Klussmann, Sven] NOXXON Pharma AG, D-10589 Berlin, Germany. [Lonardi, Silvia; Ungari, Marco; Facchetti, Fabio] Univ Brescia, Sch Med, Spedali Civili Brescia, Dept Pathol, I-25123 Brescia, Italy. [Rossi, Giuseppe] Spedali Civili Brescia, Dept Hematol, Ctr Ric Oncoematol AIL, CREA, I-25123 Brescia, Italy. RP Ghobrial, IM (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. EM irene_ghobrial@dfci.harvard.edu RI Rossi, Giuseppe/K-3376-2016; Sacco, Antonio/K-4681-2016; Reagan, Michaela/E-3549-2017; FACCHETTI, Fabio/E-7190-2010; OI Rossi, Giuseppe/0000-0001-8377-2898; Sacco, Antonio/0000-0003-2945-9416; Vater, Axel/0000-0003-4166-982X; Roccaro, Aldo/0000-0002-1872-5128; Maiso, Patricia/0000-0003-3745-1924; FACCHETTI, Fabio/0000-0003-4975-2388; Reagan, Michaela/0000-0003-2884-6481 FU NCI NIH HHS [R01 CA125690, R01 CA133799, R01 CA181683] NR 40 TC 23 Z9 23 U1 1 U2 7 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 2211-1247 J9 CELL REP JI Cell Reports PD OCT 9 PY 2014 VL 9 IS 1 BP 118 EP 128 DI 10.1016/j.celrep.2014.08.042 PG 11 WC Cell Biology SC Cell Biology GA AS7YP UT WOS:000344468100012 PM 25263552 ER PT J AU Lan, YY Londono, D Bouley, R Rooney, MS Hacohen, N AF Lan, Yuk Yuen Londono, Diana Bouley, Richard Rooney, Michael S. Hacohen, Nir TI Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy SO CELL REPORTS LA English DT Article ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; INNATE IMMUNE RECOGNITION; NF-KAPPA-B; EXONUCLEASE TREX1; PIECEMEAL MICROAUTOPHAGY; AUTOIMMUNE-DISEASE; MAMMALIAN-CELLS; I INTERFERON; SELF DNA; MICE AB Deficiencies in DNA-degrading nucleases lead to accumulation of self DNA and induction of autoimmunity in mice and in monogenic and polygenic human diseases. However, the sources of DNA and the mechanisms that trigger immunity remain unclear. We analyzed mice deficient for the lysosomal nuclease Dnase2a and observed elevated levels of undegraded DNA in both phagocytic and nonphagocytic cells. In nonphagocytic cells, the excess DNA originated from damaged DNA in the nucleus based on colocalization studies, live-cell imaging, and exacerbation by DNA-damaging agents. Removal of damaged DNA by Dnase2a required nuclear export and autophagy-mediated delivery of the DNA to lysosomes. Finally, DNA was found to accumulate in Dnase2a(-/-) or autophagy-deficient cells and induce inflammation via the Sting cytosolic DNA-sensing pathway. Our results reveal a cell-autonomous process for removal of damaged nuclear DNA with implications for conditions with elevated DNA damage, such as inflammation, cancer, and chemotherapy. C1 [Lan, Yuk Yuen; Londono, Diana; Hacohen, Nir] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA. [Lan, Yuk Yuen; Rooney, Michael S.; Hacohen, Nir] Broad Inst, Cambridge, MA 02142 USA. [Lan, Yuk Yuen; Hacohen, Nir] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. [Bouley, Richard] Massachusetts Gen Hosp, Program Membrane Biol, Ctr Syst Biol, Boston, MA 02114 USA. [Bouley, Richard] Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02114 USA. Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hacohen, N (reprint author), Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, 149 13th St, Charlestown, MA 02129 USA. EM nhacohen@partners.org FU NIH [DK43351, DK57521]; NIH Director's New Innovator Award [DP2 OD002230]; MGH Research Scholars Program; [T32 DK007540-22]; [T32 AI060548-04]; [T32 AI060548-05] FX We thank S. Nagata and K. Kawane (Kyoto University) for Dnase2a-deficient mice; R. Xavier for Atg5-/- MEFs; F. Marangoni, F. Castelino, and N. Sakai for technical advice; W. Li, M. Roy, and M. Lee for technical help and reagents. We thank C. Vaziri for advice on DNA damaging agents. We thank R. Deering, T. Eisenhaure, M. Jovanovic, D.-A. Landau, M. Lee, K. Maciag, W. Pendergraft, and C. Villani of N.H.'s laboratory, for comments on the manuscript. We appreciate assistance of T.J. Diefenbach with confocal microscopy at the Ragon Institute Imaging Core; R. Mylvaganam with flow sorting at the Department of Pathology; M. McKee with electron microscopy at the Center for Systems Biology/Program in Membrane Biology, (supported by NIH DK43351 and DK57521); and the CCM staff for laboratory animal care. Y.Y.L. thanks M.A. Arnaout (T32 DK007540-22) and A.D. Luster (T32 AI060548-04, T32 AI060548-05) for training grant support. This work was supported by the NIH Director's New Innovator Award (DP2 OD002230) and the MGH Research Scholars Program to N.H. NR 65 TC 30 Z9 32 U1 0 U2 7 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 2211-1247 J9 CELL REP JI Cell Reports PD OCT 9 PY 2014 VL 9 IS 1 BP 180 EP 192 DI 10.1016/j.celrep.2014.08.074 PG 13 WC Cell Biology SC Cell Biology GA AS7YP UT WOS:000344468100017 PM 25284779 ER PT J AU Platt, RJ Chen, SD Zhou, Y Yim, MJ Swiech, L Kempton, HR Dahlman, JE Parnas, O Eisenhaure, TM Jovanovic, M Graham, DB Jhunjhunwala, S Heidenreich, M Xavier, RJ Langer, R Anderson, DG Hacohen, N Regev, A Feng, GP Sharp, PA Zhang, F AF Platt, Randall J. Chen, Sidi Zhou, Yang Yim, Michael J. Swiech, Lukasz Kempton, Hannah R. Dahlman, James E. Parnas, Oren Eisenhaure, Thomas M. Jovanovic, Marko Graham, Daniel B. Jhunjhunwala, Siddharth Heidenreich, Matthias Xavier, Ramnik J. Langer, Robert Anderson, Daniel G. Hacohen, Nir Regev, Aviv Feng, Guoping Sharp, Phillip A. Zhang, Feng TI CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling SO CELL LA English DT Article ID ZINC-FINGER NUCLEASES; GENE-EXPRESSION; HUMAN-CELLS; HOMOLOGOUS RECOMBINATION; CRE RECOMBINASE; LUNG-CANCER; VECTORS; SYSTEM; RNA; DNA AB CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in vivo as well as ex vivo genome editing using adeno-associated virus (AAV)-, lentivirus-, or particle-mediated delivery of guide RNA in neurons, immune cells, and endothelial cells. Using these mice, we simultaneously modeled the dynamics of KRAS, p53, and LKB1, the top three significantly mutated genes in lung adenocarcinoma. Delivery of a single AAV vector in the lung generated loss-of-function mutations in p53 and Lkb1, as well as homology-directed repair-mediated Kras(G12D) mutations, leading to macroscopic tumors of adenocarcinoma pathology. Together, these results suggest that Cas9 mice empower a wide range of biological and disease modeling applications. C1 [Platt, Randall J.; Yim, Michael J.; Swiech, Lukasz; Kempton, Hannah R.; Parnas, Oren; Eisenhaure, Thomas M.; Jovanovic, Marko; Graham, Daniel B.; Heidenreich, Matthias; Xavier, Ramnik J.; Hacohen, Nir; Regev, Aviv; Feng, Guoping; Zhang, Feng] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA. [Platt, Randall J.; Zhou, Yang; Yim, Michael J.; Swiech, Lukasz; Kempton, Hannah R.; Heidenreich, Matthias; Feng, Guoping; Zhang, Feng] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA. [Platt, Randall J.; Zhou, Yang; Yim, Michael J.; Swiech, Lukasz; Heidenreich, Matthias; Feng, Guoping; Zhang, Feng] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA. [Platt, Randall J.; Yim, Michael J.; Swiech, Lukasz; Kempton, Hannah R.; Heidenreich, Matthias; Zhang, Feng] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Chen, Sidi; Dahlman, James E.; Jhunjhunwala, Siddharth; Langer, Robert; Anderson, Daniel G.; Sharp, Phillip A.] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. [Chen, Sidi; Regev, Aviv; Sharp, Phillip A.] MIT, Dept Biol, Cambridge, MA 02139 USA. [Dahlman, James E.; Langer, Robert; Anderson, Daniel G.] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Dahlman, James E.; Langer, Robert; Anderson, Daniel G.] MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA. [Langer, Robert; Anderson, Daniel G.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Hacohen, Nir] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Eisenhaure, Thomas M.; Hacohen, Nir] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA. [Regev, Aviv] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA. [Feng, Guoping; Zhang, Feng] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA. RP Sharp, PA (reprint author), MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM sharppa@mit.edu; zhang@broadinstitute.org OI Jhunjhunwala, Siddharth/0000-0001-8046-2288 FU Swanson Biotechnology Center; National Science Foundation Graduate Research Fellowship [1122374]; Simons Center for the Social Brain at MIT; NDSEG; NSF; MIT; Swiss National Science Foundation (SNF); Marie Sklodowska-Curie IOF; Helmsley CharitableTrust; Human Frontiers Science Program; NHGRI CEGS [P50 HG006193]; HHMI; Klarman Cell Observatory; NIH Centers of Cancer Nanotechnology Excellence grant [U54CA151884]; NIH Controlled Release grant [EB000244]; National Heart, Lung, and Blood Institute, National Institutes of Health [HHSN268201000045C]; McGovern Internal Funding Poitras Gift [1631119]; Stanley Center; SFARI/Simons Foundation [6927482]; Nancy Lurie Marks Family Foundation [6928117]; United States Public Health Service from the National Institutes of Health [R01-CA133404]; MIT-Harvard Center for Cancer Nanotechnology Excellence Grant from the National Cancer Institute [U54 CA151884]; Marie D. and Pierre Casimir-Lambert Fund; SkTech/MIT Initiative Grant from the Skolkovo Foundation; Koch Institute Support (core) grant from the National Cancer Institute [P30-CA14051]; NIMH through NIH [DP1-MH100706]; NINDS through NIH [R01-NS 07312401]; NSF Waterman Award; Keck Foundation; Damon Runyon Foundation; Searle Scholars Foundation; Klingenstein Foundation; Vallee Foundation; Merkin Foundation; Simons Foundation; Bob Metcalfe; [DK43351] FX We thank the entire Zhang laboratory and Sharp laboratory. We thank J.T. Ting, I. Tirosh, N. Sanjana, S. Jones, Y. Li, and colleagues in the Broad and Koch Institutes for technical assistance and discussions. We thank the Swanson Biotechnology Center for their support (Applied Therapeutics and Whole Animal Imaging, Bioinformatics and Computing, ES Cell and Transgenics, Microscopy, Flow Cytometry, and Histology, in particular). R.J.P. is supported by a National Science Foundation Graduate Research Fellowship under grant number 1122374. S. C. is a Damon Runyon Cancer Research Fellow (DRG-2117-12). Y.Z. is supported by the Simons Center for the Social Brain at MIT, postdoctoral fellowship. L. S. is a European Molecular Biology Organization (EMBO) and Foundation for Polish Science (FNP) Fellow. J.E.D. is supported by the NDSEG, NSF, and MIT Presidential Graduate Fellowships. M.J. is supported by fellowships of the Swiss National Science Foundation for advanced researchers (SNF) and the Marie Sklodowska-Curie IOF. R.J.X. and D. G. are supported by the Helmsley CharitableTrust and DK43351. M. H. is supported by a postdoctoral fellowship from the Human Frontiers Science Program. A. R. is supported by NHGRI CEGS P50 HG006193, HHMI and the Klarman Cell Observatory. N. H. is supported by NHGRI CEGS P50 HG006193. R. L. and D. A. G. are supported by the NIH Centers of Cancer Nanotechnology Excellence grant U54CA151884, the Controlled Release grant EB000244, and the National Heart, Lung, and Blood Institute, National Institutes of Health, as a Program of Excellence in Nanotechnology (PEN) Award, contract HHSN268201000045C. G. F. is supported by the McGovern Internal Funding Poitras Gift 1631119, the Stanley Center, the SFARI/Simons Foundation 6927482, and the Nancy Lurie Marks Family Foundation 6928117. P. A. S. is supported by United States Public Health Service R01-CA133404 from the National Institutes of Health; by an MIT-Harvard Center for Cancer Nanotechnology Excellence Grant U54 CA151884 from the National Cancer Institute; by a generous gift from the Marie D. and Pierre Casimir-Lambert Fund; by an SkTech/MIT Initiative Grant from the Skolkovo Foundation; and partially by the Koch Institute Support (core) grant P30-CA14051 from the National Cancer Institute. F.Z. is supported by the NIMH through a NIH Director's Pioneer Award (DP1-MH100706), the NINDS through a NIH Transformative R01 grant (R01-NS 07312401), NSF Waterman Award, the Keck, Damon Runyon, Searle Scholars, Klingenstein, Vallee, Merkin, and Simons Foundations, and Bob Metcalfe. CRISPR reagents are available to the academic community through Addgene, and associated protocols, support forum, and computational tools are available via the Zhang lab website (http://www.genome-engineering.org). The Cre-dependent Cas9 (JAX Stock Number: 024857) and constitutive Cas9-expressing (JAX Stock Number: 024858) mice are available via the Jackson Laboratory. NR 62 TC 222 Z9 246 U1 60 U2 303 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 EI 1097-4172 J9 CELL JI Cell PD OCT 9 PY 2014 VL 159 IS 2 BP 440 EP 455 DI 10.1016/j.cell.2014.09.014 PG 16 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA AQ8QU UT WOS:000343095600023 PM 25263330 ER PT J AU Wang, CN Schroeder, FA Wey, HY Borra, R Wagner, FF Reis, S Kim, SW Holson, EB Haggarty, SJ Hooker, JM AF Wang, Changning Schroeder, Frederick A. Wey, Hsiao-Ying Borra, Ronald Wagner, Florence F. Reis, Surya Kim, Sung Won Holson, Edward B. Haggarty, Stephen J. Hooker, Jacob M. TI In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID GENOME-WIDE ASSOCIATION; BRAIN; PET; INHIBITORS; DISEASE; OVEREXPRESSION; CANCER; RADIOLIGANDS; ACETYLATION; HYPERTROPHY AB Epigenetic enzymes are now targeted to treat the underlying gene expression dysregulation that contribute to disease pathogenesis. Histone deacetylases (HDACs) have shown broad potential in treatments against cancer and emerging data supports their targeting in the context of cardiovascular disease and central nervous system dysfunciton Development of a molecular agent for non-invasive imaing to elucidate the distribution and functional role of HDACs in humans will accelerate medical research and drug discovery in this domain. Herein, we describe the synthesis and validation of an HDAC imaging agent, [C-11]6. Our imaging results demonstrate that this probe has high specificity, good selectivity, and appropriate kinetics and distribution for imaging HDACs in the brian, heart, kidney, pancreas. and spleen. Our findings support the translational potential for [C-11]6 for human epigenetic imaging. C1 [Wang, Changning; Schroeder, Frederick A.; Wey, Hsiao-Ying; Borra, Ronald; Hooker, Jacob M.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging,Dept Radi, Charlestown, MA 02129 USA. [Schroeder, Frederick A.; Reis, Surya; Haggarty, Stephen J.] Massachusetts Gen Hosp, Ctr Human Genet Res, Chem Neurobiol Lab, Dept Neurol, Boston, MA 02114 USA. [Schroeder, Frederick A.; Reis, Surya; Haggarty, Stephen J.] Massachusetts Gen Hosp, Ctr Human Genet Res, Chem Neurobiol Lab, Dept Psychiat, Boston, MA 02114 USA. [Wagner, Florence F.; Holson, Edward B.] Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge Ctr 7, Cambridge, MA 02142 USA. [Kim, Sung Won] NIAAA, Lab Neuroimaging, Bethesda, MD 20892 USA. RP Hooker, JM (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging,Dept Radi, 73 High St, Charlestown, MA 02129 USA. EM hooker@nmr.mgh.harvard.edu OI Haggarty, Stephen J./0000-0002-7872-168X FU Harvard/MGH Nuclear Medicine Training Program from the Department of Energy [DE-SC0008430]; National Institute of Drug Abuse (NIDA) of the National Institutes of Health [R01DA030321, R01DA028301]; National Institute of Biomedical Imaging and Bioengineering (NIBIB); National Institutes of Health; NIH [S10RR017208, S10RR026666, S10RR022976, S10RR019933, S10RR029495] FX C.W. and H.Y.W. are supported by the Harvard/MGH Nuclear Medicine Training Program from the Department of Energy (DE-SC0008430). Research was supported by the National Institute of Drug Abuse (NIDA) of the National Institutes of Health under grant numbers R01DA030321 (J.M.H.; SJ.H) with additional support under grant R01DA028301 (SJ.H.). This research was carried out at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using resources provided by the Center for Functional Neuroirnaging Technologies, P41EB015896, a P41 Regional Resource supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health. This work also involved the use of instrumentation supported by the NIH Shared Instrumentation Grant Program and/or High-End Instrumentation Grant Program; specifically, grant nos: S10RR017208, S10RR026666, S10RR022976, S10RR019933, and S10RR029495. The authors are grateful to Joe Mandeville and Helen Deng as well as the Martinos Center radiopharmacy and imaging staff (Grae Arabasz, Shirley Hsu, Stephen Carlin, Chris Moseley, Nathan Schauer, Ehimen Aisaborhale, Judit Sore) for help with nonhuman primate experiments. HDAC activity screening was enabled by a Caliper assay developed by Jennifer Gale and Yan-Ling Zhang at the Broad Institute. NR 45 TC 13 Z9 13 U1 6 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD OCT 9 PY 2014 VL 57 IS 19 BP 7999 EP 8009 DI 10.1021/jm500872 PG 11 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA AQ7RG UT WOS:000343016300015 PM 25203558 ER PT J AU De Raedt, T Beert, E Pasmant, E Luscan, A Brems, H Ortonne, N Helin, K Hornick, JL Mautner, V Kehrer-Sawatzki, H Clapp, W Bradner, J Vidaud, M Upadhyaya, M Legius, E Cichowski, K AF De Raedt, Thomas Beert, Eline Pasmant, Eric Luscan, Armelle Brems, Hilde Ortonne, Nicolas Helin, Kristian Hornick, Jason L. Mautner, Victor Kehrer-Sawatzki, Hildegard Clapp, Wade Bradner, James Vidaud, Michel Upadhyaya, Meena Legius, Eric Cichowski, Karen TI PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies SO NATURE LA English DT Article ID BET BROMODOMAIN INHIBITION; NF1 MICRODELETION PATIENTS; NEUROFIBROMATOSIS TYPE-1; CANCER; TUMORS; GENE; SUPPRESSOR; MUTATIONS; MICE; EZH2 AB The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types(1). However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, suggesting that this complex plays a dichotomous and poorly understood role in cancer(2,3). Here we provide genomic, cellular, and mouse modelling data demonstrating that the polycomb group gene SUZ12 functions as tumour suppressor in PNS tumours, high-grade gliomas and melanomas by cooperating with mutations in NF1. NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives cancer by activating Ras(4). We show that SUZ12 loss potentiates the effects of NF1 mutations by amplifying Ras-driven transcription through effects on chromatin. Importantly, however, SUZ12 inactivation also triggers an epigenetic switch that sensitizes these cancers to bromodomain inhibitors. Collectively, these studies not only reveal an unexpected connection between the PRC2 complex, NF1 and Ras, but also identify a promising epigenetic-based therapeutic strategy that may be exploited for a variety of cancers. C1 [De Raedt, Thomas; Cichowski, Karen] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA. [De Raedt, Thomas; Bradner, James; Cichowski, Karen] Harvard Univ, Sch Med, Boston, MA 02115 USA. [De Raedt, Thomas; Cichowski, Karen] Dana Farber Harvard Canc Ctr, Ludwig Ctr, Boston, MA 02115 USA. [Beert, Eline; Brems, Hilde; Legius, Eric] Katholieke Univ Leuven, Dept Human Genet, B-3000 Leuven, Belgium. [Pasmant, Eric; Luscan, Armelle; Ortonne, Nicolas; Vidaud, Michel] Univ Paris 05, Sorbonne Paris Cite, Fac Sci Pharmaceut & Biol, INSERM UMR S745, F-75006 Paris, France. [Pasmant, Eric; Luscan, Armelle; Ortonne, Nicolas; Vidaud, Michel] Univ Paris 05, Sorbonne Paris Cite, Fac Sci Pharmaceut & Biol, EA7331, F-75006 Paris, France. [Pasmant, Eric; Luscan, Armelle; Ortonne, Nicolas; Vidaud, Michel] Hop Cochin, AP HP, Serv Biochim & Genet Mol, F-75014 Paris, France. [Helin, Kristian] Univ Copenhagen, BRIC, DK-2200 Copenhagen, Denmark. [Helin, Kristian] Univ Copenhagen, Ctr Epigenet, DK-2200 Copenhagen, Denmark. [Helin, Kristian] Univ Copenhagen, Danish Stem Cell Ctr Danstem, DK-2200 Copenhagen, Denmark. [Hornick, Jason L.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Mautner, Victor] Univ Med Ctr, Dept Maxillofacial Surg, D-20246 Hamburg, Germany. [Kehrer-Sawatzki, Hildegard] Univ Ulm, Inst Human Genet, D-89081 Ulm, Germany. [Clapp, Wade] Indiana Univ Sch Med, Dept Pediat, Herman Wells Ctr Pediat Res, Indianapolis, IN 46202 USA. [Bradner, James] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Upadhyaya, Meena] Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales. [Legius, Eric] Univ Hosp Leuven, Ctr Human Genet, B-3000 Leuven, Belgium. RP Cichowski, K (reprint author), Brigham & Womens Hosp, Dept Med, Div Genet, 75 Francis St, Boston, MA 02115 USA. EM Eric.Legius@uzleuven.be; kcichowski@rics.bwh.harvard.edu OI Helin, Kristian/0000-0003-1975-6097 FU US Department of Defense [W81XWH-11-1-0138]; Ludwig Center at DF/HCC and the Children's Tumor Foundation; Children's Tumor Foundation; FWO-Flanders [G.0784.10N]; Emmanuel Vanderschueren Fellowship from the Vlaamse Liga tegen Kanker FX This work was supported by the following organizations: The US Department of Defense (W81XWH-11-1-0138), the Ludwig Center at DF/HCC and the Children's Tumor Foundation (K.C.); T.D. was a recipient of the Young Investigator Award of the Children's Tumor Foundation; FWO-Flanders G.0784.10N (E.L.). E.B. was a recipient of an Emmanuel Vanderschueren Fellowship from the Vlaamse Liga tegen Kanker. Association Neurofibromatoses et Recklinghausen, Ligue Francaise Contre les Neurofibromatoses, Association pour la Recherche sur le Cancer, Comite de Paris de la Ligue Contre le Cancer, the French Clinical Research program (PHRC 2002, P. Wolkenstein) and INSERM (Nf1GeneModif project) (M.V. and E.P.). We thank the Platform of Biological Resources, Assistance Publique Hopitaux de Paris, Hopital Henri Mondor, Creteil, France, for providing tissue samples. NR 33 TC 75 Z9 75 U1 2 U2 25 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD OCT 9 PY 2014 VL 514 IS 7521 BP 247 EP + DI 10.1038/nature13561 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ3BG UT WOS:000342663100046 PM 25119042 ER PT J AU Hacein-Bey-Abina, S Pai, SY Gaspar, HB Armant, M Berry, CC Blanche, S Bleesing, J Blondeau, J de Boer, H Buckland, KF Caccavelli, L Cros, G De Oliveira, S Fernandez, KS Guo, D Harris, CE Hopkins, G Lehmann, LE Lim, A London, WB van der Loo, JCM Malani, N Male, F Malik, P Marinovic, MA McNicol, AM Moshous, D Neven, B Oleastro, M Picard, C Ritz, J Rivat, C Schambach, A Shaw, KL Sherman, EA Silberstein, LE Six, E Touzot, F Tsytsykova, A Xu-Bayford, J Baum, C Bushman, FD Fischer, A Kohn, DB Filipovich, AH Notarangelo, LD Cavazzana, M Williams, DA Thrasher, AJ AF Hacein-Bey-Abina, S. Pai, S. -Y. Gaspar, H. B. Armant, M. Berry, C. C. Blanche, S. Bleesing, J. Blondeau, J. de Boer, H. Buckland, K. F. Caccavelli, L. Cros, G. De Oliveira, S. Fernandez, K. S. Guo, D. Harris, C. E. Hopkins, G. Lehmann, L. E. Lim, A. London, W. B. van der Loo, J. C. M. Malani, N. Male, F. Malik, P. Marinovic, M. A. McNicol, A. -M. Moshous, D. Neven, B. Oleastro, M. Picard, C. Ritz, J. Rivat, C. Schambach, A. Shaw, K. L. Sherman, E. A. Silberstein, L. E. Six, E. Touzot, F. Tsytsykova, A. Xu-Bayford, J. Baum, C. Bushman, F. D. Fischer, A. Kohn, D. B. Filipovich, A. H. Notarangelo, L. D. Cavazzana, M. Williams, D. A. Thrasher, A. J. TI A Modified gamma-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID HEMATOPOIETIC STEM-CELLS; SCID-X1 GENE-THERAPY; DNA INTEGRATION; TRANSPLANTATION; DEFICIENCY; RECONSTITUTION; SURVIVAL; MARROW; SITES; FATE AB BACKGROUND In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based gamma-retrovirus vector expressing interleukin-2 receptor gamma-chain (gamma c) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients. We assessed the efficacy and safety of a self-inactivating retrovirus for the treatment of SCID-X1. METHODS We enrolled nine boys with SCID-X1 in parallel trials in Europe and the United States to evaluate treatment with a self-inactivating (SIN) gamma-retrovirus vector containing deletions in viral enhancer sequences expressing gamma c (SIN-gamma c). RESULTS All patients received bone marrow-derived CD34+ cells transduced with the SIN-gamma c vector, without preparative conditioning. After 12.1 to 38.7 months of follow-up, eight of the nine children were still alive. One patient died from an overwhelming adenoviral infection before reconstitution with genetically modified T cells. Of the remaining eight patients, seven had recovery of peripheral-blood T cells that were functional and led to resolution of infections. The patients remained healthy thereafter. The kinetics of CD3+ T-cell recovery was not significantly different from that observed in previous trials. Assessment of insertion sites in peripheral blood from patients in the current trial as compared with those in previous trials revealed significantly less clustering of insertion sites within LMO2, MECOM, and other lymphoid proto-oncogenes in our patients. CONCLUSIONS This modified gamma-retrovirus vector was found to retain efficacy in the treatment of SCID-X1. The long-term effect of this therapy on leukemogenesis remains unknown. C1 [Hacein-Bey-Abina, S.; Blondeau, J.; Caccavelli, L.; Touzot, F.; Cavazzana, M.] Univ Paris 05, Dept Biotherapy, Le Kremlin Bicetre, France. [Blanche, S.; Cros, G.; Moshous, D.; Neven, B.; Picard, C.; Touzot, F.; Fischer, A.] Univ Paris 05, Dept Immunol & Pediat Hematol, Le Kremlin Bicetre, France. [Picard, C.] Univ Paris 05, Ctr Etud Deficits Immunitaires, Le Kremlin Bicetre, France. [Hacein-Bey-Abina, S.; Blondeau, J.; Caccavelli, L.; Touzot, F.; Cavazzana, M.] Univ Paris 05, Hop Necker Enfants Malad, AP HP,INSERM, Biotherapy Clin Invest Ctr,Grp Hosp Univ Ouest, Le Kremlin Bicetre, France. [Hacein-Bey-Abina, S.] Univ Paris 05, Fac Sci Pharmaceut & Biol, Unite Technol Chim & Biol Sante, CNRS,INSERM 8258,U1022, Le Kremlin Bicetre, France. [Hacein-Bey-Abina, S.] Univ Paris 11, Grp Hosp, AP HP, Immunol Lab, Le Kremlin Bicetre, France. [Blanche, S.; Blondeau, J.; Caccavelli, L.; Moshous, D.; Neven, B.; Picard, C.; Six, E.; Fischer, A.; Cavazzana, M.] Imagine Inst, Paris, France. [Blondeau, J.; Caccavelli, L.; Six, E.; Touzot, F.; Fischer, A.; Cavazzana, M.] Lab Human Lymphohematopoiesis, INSERM, Unite Mixtes Rech 1163, Paris, France. [Lim, A.] Inst Pasteur, Dept Immunol, Grp Immunoscope, F-75724 Paris, France. [Fischer, A.] Coll France, F-75231 Paris, France. [Pai, S. -Y.; de Boer, H.; Guo, D.; Harris, C. E.; Hopkins, G.; Lehmann, L. E.; London, W. B.; Williams, D. A.] Harvard Univ, Sch Med, Div Hematol Oncol, Boston, MA USA. [Notarangelo, L. D.] Harvard Univ, Sch Med, Div Immunol, Boston, MA USA. [Pai, S. -Y.; Guo, D.; Lehmann, L. E.; London, W. B.; Williams, D. A.] Harvard Univ, Sch Med, Boston Childrens Hosp, Dana Farber Canc Inst,Dept Pediat Oncol, Boston, MA USA. [Pai, S. -Y.; Armant, M.; Lehmann, L. E.; London, W. B.; Ritz, J.; Silberstein, L. E.; Tsytsykova, A.; Notarangelo, L. D.; Williams, D. A.] Harvard Univ, Sch Med, Boston, MA USA. [Armant, M.; Ritz, J.; Silberstein, L. E.; Tsytsykova, A.] Boston Childrens Hosp, Ctr Human Cell Therapy, Program Cellular & Mol Med, Boston, MA 02115 USA. [Ritz, J.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Notarangelo, L. D.] Manton Ctr Orphan Dis Res, Boston, MA USA. [Gaspar, H. B.; Buckland, K. F.; McNicol, A. -M.; Rivat, C.; Thrasher, A. J.] Great Ormond St Hosp Children NHS Fdn Trust, London, England. [Gaspar, H. B.; Buckland, K. F.; McNicol, A. -M.; Rivat, C.; Thrasher, A. J.] UCL, Inst Child Hlth, Sect Mol & Cellular Immunol, London WC1E 6BT, England. [Berry, C. C.] Univ Calif San Diego, Dept Family & Prevent Med, Div Biostat & BioInformat, La Jolla, CA 92093 USA. [Bleesing, J.; Filipovich, A. H.] Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA. [van der Loo, J. C. M.; Malik, P.] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA. [De Oliveira, S.; Kohn, D. B.] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Mattel Childrens Hosp, Dept Pediat,Childrens Discovery & Innovat Inst, Los Angeles, CA 90095 USA. Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA. [Fernandez, K. S.] Univ Illinois, Coll Med, Peoria, IL 61656 USA. [Malani, N.; Male, F.; Sherman, E. A.] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA. [Marinovic, M. A.] Clin Santa Maria, Unidad Inmunol & Alergias, Santiago, Chile. [Oleastro, M.] Hosp Nacl Pediat Garrahan, Serv Inmunol Reumatol, Buenos Aires, DF, Argentina. [Schambach, A.; Baum, C.] Hannover Med Sch, Inst Expt Hematol, Hannover, Germany. RP Williams, DA (reprint author), Boston Childrens Hosp, Dana Farber Boston Childrens Canc & Blood Disorde, 300 Longwood Ave,Karp 08125-3, Boston, MA 02115 USA. EM alain.fischer@nck.aphp.fr; dawilliams@childrens.harvard.edu RI De Oliveira, Satiro/D-8860-2014; Moshous, Despina/B-7507-2017; Notarangelo, Luigi/F-9718-2016 OI De Oliveira, Satiro/0000-0002-8181-7316; Notarangelo, Luigi/0000-0002-8335-0262 FU National Institutes of Health FX Funded by the National Institutes of Health and others; ClinicalTrials.gov numbers, NCT01410019, NCT01175239, and NCT01129544. NR 37 TC 79 Z9 83 U1 3 U2 34 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 9 PY 2014 VL 371 IS 15 BP 1407 EP 1417 DI 10.1056/NEJMoa1404588 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA AQ3FJ UT WOS:000342674800009 PM 25295500 ER PT J AU Wagle, N Grabiner, BC Van Allen, EM Amin-Mansour, A Taylor-Weiner, A Rosenberg, M Gray, N Barletta, JA Guo, YN Swanson, SJ Ruan, DT Hanna, GJ Haddad, RI Getz, G Kwiatkowski, DJ Carter, SL Sabatini, DM Janne, PA Garraway, LA Lorch, JH AF Wagle, Nikhil Grabiner, Brian C. Van Allen, Eliezer M. Amin-Mansour, Ali Taylor-Weiner, Amaro Rosenberg, Mara Gray, Nathanael Barletta, Justine A. Guo, Yanan Swanson, Scott J. Ruan, Daniel T. Hanna, Glenn J. Haddad, Robert I. Getz, Gad Kwiatkowski, David J. Carter, Scott L. Sabatini, David M. Jaenne, Pasi A. Garraway, Levi A. Lorch, Jochen H. TI Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID TUBEROUS SCLEROSIS COMPLEX; MTOR MUTATIONS; GENE-PRODUCTS; ACTIVATION; SIROLIMUS; PROTEIN; LYMPHANGIOLEIOMYOMATOSIS; ANGIOMYOLIPOMA; SENSITIVITY; INHIBITION AB Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in treating tumors harboring alterations in the mTOR pathway. Mechanisms of resistance to everolimus remain undefined. Resistance developed in a patient with metastatic anaplastic thyroid carcinoma after an extraordinary 18-month response. Whole-exome sequencing of pretreatment and drug-resistant tumors revealed a nonsense mutation in TSC2, a negative regulator of mTOR, suggesting a mechanism for exquisite sensitivity to everolimus. The resistant tumor also harbored a mutation in MTOR that confers resistance to allosteric mTOR inhibition. The mutation remains sensitive to mTOR kinase inhibitors. C1 [Wagle, Nikhil; Van Allen, Eliezer M.; Gray, Nathanael; Haddad, Robert I.; Kwiatkowski, David J.; Jaenne, Pasi A.; Garraway, Levi A.; Lorch, Jochen H.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Wagle, Nikhil; Van Allen, Eliezer M.; Gray, Nathanael; Guo, Yanan; Haddad, Robert I.; Kwiatkowski, David J.; Jaenne, Pasi A.; Garraway, Levi A.; Lorch, Jochen H.] Harvard Univ, Sch Med, Boston, MA USA. [Wagle, Nikhil; Van Allen, Eliezer M.; Guo, Yanan; Haddad, Robert I.; Kwiatkowski, David J.; Jaenne, Pasi A.; Garraway, Levi A.; Lorch, Jochen H.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Barletta, Justine A.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Swanson, Scott J.; Ruan, Daniel T.] Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA. [Hanna, Glenn J.] Brigham & Womens Hosp, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA. [Jaenne, Pasi A.] Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA USA. [Wagle, Nikhil; Van Allen, Eliezer M.; Amin-Mansour, Ali; Taylor-Weiner, Amaro; Rosenberg, Mara; Getz, Gad; Kwiatkowski, David J.; Carter, Scott L.; Sabatini, David M.; Garraway, Levi A.] Broad Inst MIT & Harvard, Cambridge, MA USA. [Grabiner, Brian C.; Sabatini, David M.] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Grabiner, Brian C.; Sabatini, David M.] MIT, Dept Biol, Cambridge, MA USA. [Grabiner, Brian C.; Sabatini, David M.] MIT, Howard Hughes Med Inst, Cambridge, MA USA. RP Lorch, JH (reprint author), Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave,D1542, Boston, MA 02115 USA. EM jochen_lorch@dfci.harvard.edu FU Next Generation Fund at the Broad Institute of Massachusetts Institute of Technology and Harvard; Novartis Pharmaceuticals; Starr Cancer Consortium; National Cancer Institute FX Supported by grants from the Next Generation Fund at the Broad Institute of Massachusetts Institute of Technology and Harvard (to Dr. Wagle), Novartis Pharmaceuticals (to Dr. Lorch), the Starr Cancer Consortium (to Dr. Garraway), and the National Cancer Institute (to Drs. Kwiatkowski and Garraway). NR 24 TC 84 Z9 86 U1 0 U2 7 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 9 PY 2014 VL 371 IS 15 BP 1426 EP 1433 DI 10.1056/NEJMoa1403352 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AQ3FJ UT WOS:000342674800011 PM 25295501 ER PT J AU Fisher, MC Stone, JH Palmer, WE AF Fisher, Mark C. Stone, John H. Palmer, William E. TI Case 31-2014: A 50-Year-Old Man with Back Pain, Fatigue, Weight Loss, and Knee Swelling SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID OF-THE-LITERATURE; ANKYLOSING-SPONDYLITIS; CLINICAL-FEATURES; DISEASE; SPONDYLODISCITIS; OSTEOMYELITIS; TUMORS; SPINE C1 [Fisher, Mark C.; Stone, John H.] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Palmer, William E.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Fisher, Mark C.; Stone, John H.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Palmer, William E.] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA. RP Fisher, MC (reprint author), Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. NR 29 TC 1 Z9 2 U1 0 U2 5 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 9 PY 2014 VL 371 IS 15 BP 1447 EP 1455 DI 10.1056/NEJMcpc1404517 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AQ3FJ UT WOS:000342674800014 PM 25295504 ER PT J AU Von Boehmer, H AF Von Boehmer, Harald TI Deciphering thymic development SO FRONTIERS IN IMMUNOLOGY LA English DT Editorial Material DE MHC-restricted antigen recognition; T cell clones; TCR alpha/beta cDNA clones; HY antigen; TCR transgenic mice; negative thymic selection; positive thymic selection ID CLASS-II REGION; T-CELL; RECEPTOR; ANTIGEN; MHC; SPECIFICITY; TRANSPORTERS; LYMPHOCYTES; COMMITMENT; THYMOCYTES C1 [Von Boehmer, Harald] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02138 USA. [Von Boehmer, Harald] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA. RP Von Boehmer, H (reprint author), Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02138 USA. EM harald_von_boehmer@dfci.harvard.edu NR 20 TC 2 Z9 2 U1 0 U2 1 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-3224 J9 FRONT IMMUNOL JI Front. Immunol. PD OCT 8 PY 2014 VL 5 AR 424 DI 10.3389/fimmu.2014.00424 PG 2 WC Immunology SC Immunology GA CI1GD UT WOS:000354490400001 PM 25339947 ER PT J AU Van Tyne, D Gilmore, MS AF Van Tyne, Daria Gilmore, Michael S. TI A Delicate Balance: Maintaining Mutualism to Prevent Disease SO CELL HOST & MICROBE LA English DT Editorial Material ID INTESTINAL MICROBIOTA; INFECTION AB The intestinal microbial ecosystem is complex, and few of the principles that contribute to homeostasis in health are well understood. Pham et al. (2014) show that a network including the epithelial interleukin-22 receptor protects against infection with the opportunistic pathogen Enterococcus faecalis through promotion of host-microbiota mutualism. C1 [Van Tyne, Daria; Gilmore, Michael S.] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA. [Van Tyne, Daria; Gilmore, Michael S.] Harvard Univ, Dept Microbiol & Immunobiol, Sch Med, Boston, MA 02114 USA. RP Gilmore, MS (reprint author), Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA. EM michael_gilmore@meei.harvard.edu FU NIAID NIH HHS [AI108710, F32 AI109855, R01 AI108710, AI109855, AI083214, P01 AI083214, R01 AI072360, AI072360] NR 10 TC 1 Z9 1 U1 1 U2 8 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 EI 1934-6069 J9 CELL HOST MICROBE JI Cell Host Microbe PD OCT 8 PY 2014 VL 16 IS 4 BP 425 EP 427 DI 10.1016/j.chom.2014.09.019 PG 4 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AR8LG UT WOS:000343826100004 PM 25299326 ER PT J AU Hooli, BV Parrado, AR Mullin, K Yip, WK Liu, T Roehr, JT Qiao, DD Jessen, F Peters, O Becker, T Ramirez, A Lange, C Bertram, L Tanzi, RE AF Hooli, Basavaraj V. Parrado, Antonio R. Mullin, Kristina Yip, Wai-Ki Liu, Tian Roehr, Johannes T. Qiao, Dandi Jessen, Frank Peters, Oliver Becker, Tim Ramirez, Alfredo Lange, Christoph Bertram, Lars Tanzi, Rudolph E. TI The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk SO NEUROLOGY LA English DT Article ID GENOME-WIDE ASSOCIATION; MILD COGNITIVE IMPAIRMENT; GENOTYPE IMPUTATION; IDENTIFIES VARIANTS; COMMON VARIANTS; ONSET; CD33; DEMENTIA; GENETICS; GERMAN AB Objectives: Recently, 2 independent studies reported that a rare missense variant, rs75932628 (R47H), in exon 2 of the gene encoding the "triggering receptor expressed on myeloid cells 2" (TREM2) significantly increases the risk of Alzheimer disease (AD) with an effect size comparable to that of the APOE epsilon 4 allele. Methods: In this study, we attempted to replicate the association between rs75932628 and AD risk by directly genotyping rs75932628 in 2 independent Caucasian family cohorts consisting of 927 families (with 1,777 affected and 1,235 unaffected) and in 2 Caucasian case-control cohorts composed of 1,314 cases and 1,609 controls. In addition, we imputed genotypes in 3 independent Caucasian case-control cohorts containing 1,906 cases and 1,503 controls. Results: Meta-analysis of the 2 family-based and the 5 case-control cohorts yielded a p value of 0.0029, while the overall summary estimate (using case-control data only) resulted in an odds ratio of 1.67 (95% confidence interval 0.95-2.92) for the association between the TREM2 R47H and increased AD risk. Conclusions: While our results serve to confirm the association between R47H and risk of AD, the observed effect on risk was substantially smaller than that previously reported. C1 [Hooli, Basavaraj V.; Parrado, Antonio R.; Mullin, Kristina; Tanzi, Rudolph E.] Massachusetts Gen Hosp, Dept Neurol, MassGen Inst Neurodegenerat Dis, Boston, MA 02114 USA. [Yip, Wai-Ki; Qiao, Dandi; Lange, Christoph] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Liu, Tian; Roehr, Johannes T.; Bertram, Lars] Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany. [Jessen, Frank; Ramirez, Alfredo] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany. [Becker, Tim] Univ Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany. [Ramirez, Alfredo] Univ Bonn, Inst Human Genet, Bonn, Germany. [Jessen, Frank; Becker, Tim] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany. [Peters, Oliver] Charite, Dept Psychiat, D-13353 Berlin, Germany. RP Tanzi, RE (reprint author), Massachusetts Gen Hosp, Dept Neurol, MassGen Inst Neurodegenerat Dis, Boston, MA 02114 USA. EM tanzi@helix.mgh.harvard.edu RI Bertram, Lars/K-3889-2015 OI Bertram, Lars/0000-0002-0108-124X FU Cure Alzheimer Fund as part of the Alzheimer Genome Project; NIA [5R01AG23667, U24 AG21886]; NIMH [5R37MH60009]; German Federal Ministry of Education and Research (BMBF) [16SV5538]; German Federal Ministry of Education and Research [KND: 01GI0102, 01GI0420, 01GI0422, 01GI0423, 01GI0429, 01GI0431, 01GI0433, 01GI0434, KNDD: 01GI0710, 01GI0711, 01GI0712, 01GI0713, 01GI0714, 01GI0715, 01GI0716, 01 ET1006B] FX Supported by the Cure Alzheimer Fund (to L. B. and R. E. T.) as part of the "Alzheimer Genome Project," and by federal grants from the NIA (5R01AG23667 to L. B.), the NIMH (5R37MH60009 to R. E. T.), and the German Federal Ministry of Education and Research (BMBF grant 16SV5538 to L. B.). Data and biomaterials were collected in 3 projects that participated in the NIMH Alzheimer Disease Genetics Initiative. From 1991 to 1998, the principal investigators and coinvestigators included the following: Massachusetts General Hospital, Boston, U01 MH46281, Marilyn S. Albert, PhD, and Deborah Blacker, MD, ScD; Johns Hopkins University, Baltimore, MD, U01 MH46290, Susan S. Bassett, PhD, Gary A. Chase, PhD, and Marshal F. Folstein, MD; and University of Alabama, Birmingham, U01 MH46373, Rodney C. P. Go, PhD, and Lindy E. Harrell, MD. Samples from the National Cell Repository for Alzheimer's Disease (NCRAD), which receives government support under a cooperative agreement grant (U24 AG21886) awarded by the NIA, were used in this study. This publication is part of the German Research Network on Dementia (KND) and the German Research Network on Degenerative Dementia (KNDD) and was funded by the German Federal Ministry of Education and Research (grants KND: 01GI0102, 01GI0420, 01GI0422, 01GI0423, 01GI0429, 01GI0431, 01GI0433, 01GI0434; grants KNDD: 01GI0710, 01GI0711, 01GI0712, 01GI0713, 01GI0714, 01GI0715, 01GI0716, 01 ET1006B). This study was not industry-sponsored. NR 30 TC 11 Z9 11 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD OCT 7 PY 2014 VL 83 IS 15 BP 1353 EP 1358 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA AU0TK UT WOS:000345337300013 PM 25186855 ER PT J AU Palacios, N Fitzgerald, KC Hart, JE Weisskopf, MG Schwarzschild, MA Ascherio, A Laden, F AF Palacios, Natalia Fitzgerald, Kathryn C. Hart, Jaime E. Weisskopf, Marc G. Schwarzschild, Michael A. Ascherio, Alberto Laden, Francine TI Particulate matter and risk of parkinson disease in a large prospective study of women SO ENVIRONMENTAL HEALTH LA English DT Article DE Epidemiology; Cohort studies; Incidence studies; Parkinson disease/Parkinsonism ID EXTENDED FOLLOW-UP; URIC-ACID LEVELS; HARVARD 6 CITIES; AIR-POLLUTION; NURSES HEALTH; MULTIPLE-SCLEROSIS; MORTALITY; EXPOSURE; MANGANESE; NEUROINFLAMMATION AB Background: Exposure to air pollution has been implicated in a number of adverse health outcomes and the effect of particulate matter (PM) on the brain is beginning to be recognized. Yet, no prospective study has examined the association between PM and risk of Parkinson Disease. Thus, our goal was assess if exposure to particulate matter air pollution is related to risk of Parkinson's disease (PD) in the Nurses' Health Study (NHS), a large prospective cohort of women. Methods: Cumulative average exposure to different size fractions of PM up to 2 years before the onset of PD, was estimated using a spatio-temporal model by linking each individual's places of residence throughout the study with location-specific air pollution levels. We prospectively followed 115,767 women in the NHS, identified 508 incident PD cases and used multivariable Cox proportional hazards models to estimate the risk of PD associated with each size fraction of PM independently. Results: In models adjusted for age in months, smoking, region, population density, caffeine and ibuprofen intake, we observed no statistically significant associations between exposure to air pollution and PD risk. The relative risk (RR) comparing the top quartile to the bottom quartile of PM exposure was 1.03 (95% Confidence Intervals (CI): 0.78, 1.37) for PM10 (<= 10 microns in diameter), 1.10 (95% CI: 0.83, 1.45) for PM2.5 (<= 2.5 microns in diameter), and 0.93 (95% CI: 0.69, 1.26) for PM10-2.5 (2.5 to 10 microns in diameter). Conclusions: In this study, we found no evidence that exposure to air pollution is a risk factor for PD. C1 [Palacios, Natalia; Fitzgerald, Kathryn C.; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Palacios, Natalia; Hart, Jaime E.; Ascherio, Alberto; Laden, Francine] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA. [Palacios, Natalia; Hart, Jaime E.; Ascherio, Alberto; Laden, Francine] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Fitzgerald, Kathryn C.; Schwarzschild, Michael A.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Hart, Jaime E.; Weisskopf, Marc G.; Laden, Francine] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Weisskopf, Marc G.; Ascherio, Alberto; Laden, Francine] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Palacios, N (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. EM palacios@hsph.harvard.edu FU NIH [K01ES019183] FX The authors would like to acknowledge Leslie Unger for administrative support and Dr. Eilis O'Reilly for statistical advice. Study Funding: Supported by NIH (K01ES019183). NR 36 TC 6 Z9 6 U1 2 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD OCT 7 PY 2014 VL 13 AR 80 DI 10.1186/1476-069X-13-80 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AS9JT UT WOS:000344559800001 PM 25294559 ER PT J AU van Wijk, DF Sjouke, B Figueroa, A Emami, H van der Valk, FM MacNabb, MH Hemphill, LC Schulte, DM Koopman, MG Lobatto, ME Verberne, HJ Fayad, ZA Kastelein, JJP Mulder, WJM Hovingh, GK Tawakol, A Stroes, ESG AF van Wijk, Diederik F. Sjouke, Barbara Figueroa, Amparo Emami, Hamed van der Valk, Fleur M. MacNabb, Megan H. Hemphill, Linda C. Schulte, Dominik M. Koopman, Marion G. Lobatto, Mark E. Verberne, Hein J. Fayad, Zahi A. Kastelein, John J. P. Mulder, Willem J. M. Hovingh, G. Kees Tawakol, Ahmed Stroes, Erik S. G. TI Nonpharmacological Lipoprotein Apheresis Reduces Arterial Inflammation in Familial Hypercholesterolemia SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article DE atherosclerosis; PET/CT imaging ID POSITRON-EMISSION-TOMOGRAPHY; CAROTID PLAQUE INFLAMMATION; STATIN THERAPY; LDL APHERESIS; FDG-PET/CT; HS-CRP; ATHEROSCLEROSIS; DISEASE; RISK; FLUORODEOXYGLUCOSE AB BACKGROUND Patients with familial hypercholesterolemia (FH) are characterized by elevated atherogenic lipoprotein particles, predominantly low-density lipoprotein cholesterol (LDL-C), which is associated with accelerated atherogenesis and increased cardiovascular risk. OBJECTIVES This study used F-18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) to investigate whether arterial inflammation is higher in patients with FH and, moreover, whether lipoprotein apheresis attenuates arterial wall inflammation in FH patients. METHODS In total, 38 subjects were recruited: 24 FH patients and 14 normolipidemic controls. All subjects underwent FDG-PET imaging at baseline. Twelve FH patients who met the criteria for lipoprotein apheresis underwent apheresis procedures followed by a second FDG-PET imaging 3 days (range 1 to 4 days) after apheresis. Subsequently, the target-to-background ratio (TBR) of FDG uptake within the arterial wall was assessed. RESULTS In FH patients, the mean arterial TBR was higher compared with healthy controls (2.12 +/- 0.27 vs. 1.92 +/- 0.19; p = 0.03). A significant correlation was observed between baseline arterial TBR and LDL-C (R = 0.37; p = 0.03) that remained significant after adjusting for statin use (beta = 0.001; p = 0.02) and atherosclerosis risk factors (beta = 0.001; p = 0.03). LDL-C levels were significantly reduced after lipoprotein apheresis (284 +/- 118 mg/dl vs. 127 +/- 50 mg/dl; p < 0.001). There was a significant reduction of arterial inflammation after lipoprotein apheresis (TBR: 2.05 +/- 0.31 vs. 1.91 +/- 0.33; p < 0.02). CONCLUSIONS The arterial wall of FH patients is characterized by increased inflammation, which is markedly reduced after lipoprotein apheresis. This lends support to a causal role of apoprotein B-containing lipoproteins in arterial wall inflammation and supports the concept that lipoprotein-lowering therapies may impart anti-inflammatory effects by reducing atherogenic lipoproteins. (C) 2014 by the American College of Cardiology Foundation. C1 [van Wijk, Diederik F.; Sjouke, Barbara; van der Valk, Fleur M.; Schulte, Dominik M.; Lobatto, Mark E.; Kastelein, John J. P.; Mulder, Willem J. M.; Hovingh, G. Kees; Stroes, Erik S. G.] Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands. [Figueroa, Amparo; Emami, Hamed; MacNabb, Megan H.; Hemphill, Linda C.; Tawakol, Ahmed] Massachusetts Gen Hosp, Cardiac MR PET CT Program, Boston, MA 02114 USA. [Figueroa, Amparo; Emami, Hamed; MacNabb, Megan H.; Hemphill, Linda C.; Tawakol, Ahmed] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Figueroa, Amparo; Emami, Hamed; MacNabb, Megan H.; Hemphill, Linda C.; Tawakol, Ahmed] Harvard Univ, Sch Med, Boston, MA USA. [Schulte, Dominik M.] Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Internal Med 1, Kiel, Germany. [Koopman, Marion G.] Acad Med Ctr, Dept Nephrol, Amsterdam, Netherlands. [Lobatto, Mark E.; Fayad, Zahi A.; Mulder, Willem J. M.] Mt Sinai Sch Med, Translat & Mol Imaging Inst, New York, NY USA. [Verberne, Hein J.] Acad Med Ctr, Dept Nucl Med, Amsterdam, Netherlands. RP van Wijk, DF (reprint author), Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands. FU Dutch Heart Foundation (CVON : Genius) [2011B019]; Veni grant from the Netherlands Organisation for Scientific Research (NWO) [91612122]; Regeneron; Novartis; Merck Co.; ISIS; Boehringer Ingelheim; AstraZeneca; Eli Lilly and Company; Amgen; Aegerion; Genzyme; Sanofi-Aventis; Pfizer; Roche; BMS; Cerenis; Torrent Pharmaceuticals FX This work was partly supported by a grant from the Dutch Heart Foundation (CVON 2012: Genius, no. 2011B019). Dr. Kastelein is supported by a lifetime achievement award of the Dutch Heart Foundation. Dr. Hovingh received funding from a Veni grant (project number 91612122) from the Netherlands Organisation for Scientific Research (NWO). Dr. Hemphill has received consulting fees from Regeneron. Dr. Kastelein has received consulting and lecturing fees from Novartis, Merck & Co., ISIS, Boehringer Ingelheim, AstraZeneca, Eli Lilly and Company, Amgen, Aegerion, Genzyme, Sanofi-Aventis, Regeneron, Pfizer, and Roche. Dr. Hovingh has received lecture fees from Pfizer, Sanofi-Aventis, Amgen, Roche, and Genzyme. Dr. Tawakol has received consulting fees from BMS, Cerenis, Novartis, and Roche; and has received grants from BMS and Roche. Dr. Stroes has received lecture fees from Amgen, Sanofi-Aventis, Torrent Pharmaceuticals, Roche, Merck & Co., Novartis, ISIS, Boehringer Ingelheim, AstraZeneca, and Genzyme. NR 38 TC 30 Z9 30 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 EI 1558-3597 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD OCT 7 PY 2014 VL 64 IS 14 BP 1418 EP 1426 DI 10.1016/j.jacc.2014.01.088 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AR3CL UT WOS:000343464800003 PM 25277610 ER PT J AU Budin, I Prwyes, N Zhang, N Szostak, JW AF Budin, Itay Prwyes, Noam Zhang, Na Szostak, Jack W. TI Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions SO BIOPHYSICAL JOURNAL LA English DT Article ID MODEL PROTOCELL MEMBRANES; MONOCARBOXYLIC ACIDS; PHASE-BEHAVIOR; MIXED MICELLE; LIFE; ENCAPSULATION; AMPHIPHILES; ORIGIN; GROWTH AB A requirement for concentrated and chemically homogeneous pools of molecular building blocks would severely restrict plausible scenarios for the origin of life. In the case of membrane self-assembly, models of prebiotic lipid synthesis yield primarily short, single-chain amphiphiles that can form bilayer vesicles only at very high concentrations. These high critical aggregation concentrations (cacs) pose significant obstacles for the self-assembly of single-chain lipid membranes. Here, we examine membrane self-assembly in mixtures of fatty acids with varying chain lengths, an expected feature of any abiotic lipid synthesis. We derive theoretical predictions for the cac of mixtures by adapting thermodynamic models developed for the analogous phenomenon of mixed micelle self-assembly. We then use several complementary methods to characterize aggregation experimentally, and find cac values in close agreement with our theoretical predictions. These measurements establish that the cac of fatty acid mixtures is dramatically lowered by minor fractions of long-chain species, thereby providing a plausible route for protocell membrane assembly. Using an NMR-based approach to monitor aggregation of isotopically labeled samples, we demonstrate the incorporation of individual components into mixed vesicles. These experiments suggest that vesicles assembled in dilute, mixed solutions are depleted of the shorter-chain-length lipid species a finding that carries implications for the composition of primitive cell membranes. C1 [Budin, Itay; Prwyes, Noam; Zhang, Na; Szostak, Jack W.] Massachusetts Gen Hosp, Dept Mol Biol, Howard Hughes Med Inst, Boston, MA 02114 USA. [Budin, Itay; Prwyes, Noam; Zhang, Na; Szostak, Jack W.] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA. [Budin, Itay] Univ Calif Berkeley, Miller Inst Basic Res Sci, Berkeley, CA 94720 USA. [Zhang, Na] Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei, Peoples R China. RP Szostak, JW (reprint author), Massachusetts Gen Hosp, Dept Mol Biol, Howard Hughes Med Inst, Boston, MA 02114 USA. EM szostak@molbio.mgh.harvard.edu FU NASA Exobiology Program [EXB02-0031-0018] FX This research was supported in part by grant EXB02-0031-0018 from the NASA Exobiology Program to J.W.S. I.B. is a fellow at the Miller Institute for Basic Science. J.W.S. is an investigator of the Howard Hughes Medical Institute. NR 30 TC 7 Z9 10 U1 2 U2 23 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 EI 1542-0086 J9 BIOPHYS J JI Biophys. J. PD OCT 7 PY 2014 VL 107 IS 7 BP 1582 EP 1590 DI 10.1016/j.bpj.2014.07.067 PG 9 WC Biophysics SC Biophysics GA AQ5XA UT WOS:000342880700013 PM 25296310 ER PT J AU Sinner, MF Tucker, NR Lunetta, KL Ozaki, K Smith, JG Trompet, S Bis, JC Lin, HH Chung, MK Nielsen, JB Lubitz, SA Krijthe, BP Magnani, JW Ye, JC Gollob, MH Tsunoda, T Muller-Nurasyid, M Lichtner, P Peters, A Dolmatova, E Kubo, M Smith, JD Psaty, BM Smith, NL Jukema, W Chasman, DI Albert, CM Ebana, Y Furukawa, T MacFarlane, PW Harris, TB Darbar, D Dorr, M Holst, AG Svendsen, JH Hofman, A Uitterlinden, AG Gudnason, V Isobe, M Malik, R Dichgans, M Rosand, J Van Wagoner, DR Benjamin, EJ Milan, DJ Melander, O Heckbert, SR Ford, I Liu, YM Barnard, J Olesen, MS Stricker, BHC Tanaka, T Kaeaeb, S Ellinor, PT AF Sinner, Moritz F. Tucker, Nathan R. Lunetta, Kathryn L. Ozaki, Kouichi Smith, J. Gustav Trompet, Stella Bis, Joshua C. Lin, Honghuang Chung, Mina K. Nielsen, Jonas B. Lubitz, Steven A. Krijthe, Bouwe P. Magnani, Jared W. Ye, Jiangchuan Gollob, Michael H. Tsunoda, Tatsuhiko Mueller-Nurasyid, Martina Lichtner, Peter Peters, Annette Dolmatova, Elena Kubo, Michiaki Smith, Jonathan D. Psaty, Bruce M. Smith, Nicholas L. Jukema, Wouter Chasman, Daniel I. Albert, Christine M. Ebana, Yusuke Furukawa, Tetsushi MacFarlane, Peter W. Harris, Tamara B. Darbar, Dawood Doerr, Marcus Holst, Anders G. Svendsen, Jesper H. Hofman, Albert Uitterlinden, Andre G. Gudnason, Vilmundur Isobe, Mitsuaki Malik, Rainer Dichgans, Martin Rosand, Jonathan Van Wagoner, David R. Benjamin, Emelia J. Milan, David J. Melander, Olle Heckbert, Susan R. Ford, Ian Liu, Yongmei Barnard, John Olesen, Morten S. Stricker, Bruno H. C. Tanaka, Toshihiro Kaeaeb, Stefan Ellinor, Patrick T. CA METASTROKE Consortium AFGen Consor TI Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation SO CIRCULATION LA English DT Article DE atrial fibrillation; epidemiology; genetics; gene expression; polymorphism; single nucleotide; zebrafish ID GENOME-WIDE ASSOCIATION; ISCHEMIC-STROKE; RISK-FACTORS; PR INTERVAL; HEART-RATE; VARIANTS; ONSET; LOCI; METAANALYSIS; PRAVASTATIN AB Background-Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. Methods and Results-To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation. Four novel loci were identified in individuals of European descent near the genes NEURL (rs12415501; relative risk [RR]=1.18; 95% confidence interval [CI], 1.13-1.23; P=6.5x10(-16)), GJA1 (rs13216675; RR=1.10; 95% CI, 1.06-1.14; P=2.2x10(-8)), TBX5 (rs10507248; RR=1.12; 95% CI, 1.08-1.16; P=5.7x10(-11)), and CAND2 (rs4642101; RR=1.10; 95% CI, 1.06-1.14; P=9.8x10(-9)). In Japanese, novel loci were identified near NEURL (rs6584555; RR=1.32; 95% CI, 1.26-1.39; P=2.0x10(-25)) and CUX2 (rs6490029; RR=1.12; 95% CI, 1.08-1.16; P=3.9x10(-9)). The top single-nucleotide polymorphisms or their proxies were identified as cis-eQTLs for the genes CAND2 (P=2.6x10(-19)), GJA1 (P=2.66x10(-6)), and TBX5 (P=1.36x10(-5)). Knockdown of the zebrafish orthologs of NEURL and CAND2 resulted in prolongation of the atrial action potential duration (17% and 45%, respectively). Conclusions-We have identified 5 novel loci for AF. Our results expand the diversity of genetic pathways implicated in AF and provide novel molecular targets for future biological and pharmacological investigation. C1 [Sinner, Moritz F.; Mueller-Nurasyid, Martina; Kaeaeb, Stefan] Univ Munich, Dept Med 1, Univ Hosp Munich, D-80336 Munich, Germany. [Tucker, Nathan R.; Lubitz, Steven A.; Ye, Jiangchuan; Dolmatova, Elena; Milan, David J.; Ellinor, Patrick T.] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA USA. [Lunetta, Kathryn L.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. [Lunetta, Kathryn L.; Lin, Honghuang; Benjamin, Emelia J.] NHLBI, Framingham, MA USA. [Lunetta, Kathryn L.; Lin, Honghuang; Benjamin, Emelia J.] Boston Univ, Framingham Heart Study, Framingham, MA USA. [Ozaki, Kouichi; Tanaka, Toshihiro] RIKEN Ctr Integrat Med Sci, Lab Cardiovasc Dis, Yokohama, Kanagawa, Japan. [Smith, J. Gustav] Broad Inst Harvard & MIT, ProgramMed & Populat Genet, Cambridge, MA USA. [Smith, J. Gustav] Lund Univ, Dept Cardiol, Lund, Sweden. [Trompet, Stella; Jukema, Wouter] Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands. [Bis, Joshua C.; Psaty, Bruce M.; Smith, Nicholas L.; Heckbert, Susan R.] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA. [Bis, Joshua C.; Psaty, Bruce M.] Univ Washington, Dept Med, Seattle, WA USA. [Lin, Honghuang] Boston Univ, Sch Med, Dept Med, Computat Biomed Sect, Boston, MA 02118 USA. [Chung, Mina K.; Smith, Jonathan D.; Van Wagoner, David R.] Cleveland Clin, Dept Cardiovasc Med, Heart & Vasc Inst, Cleveland, OH 44106 USA. [Chung, Mina K.; Van Wagoner, David R.] Cleveland Clin, Dept Mol Cardiol, Lerner Res Inst, Cleveland, OH 44106 USA. [Nielsen, Jonas B.; Holst, Anders G.; Svendsen, Jesper H.; Olesen, Morten S.] Danish Natl Res Fdn, Ctr Cardiac Arrhythmia, Copenhagen, Denmark. [Nielsen, Jonas B.; Holst, Anders G.; Svendsen, Jesper H.; Olesen, Morten S.] Univ Copenhagen, Rigshosp, Mol Cardiol Lab, Ctr Heart, DK-2100 Copenhagen, Denmark. [Lubitz, Steven A.; Milan, David J.; Ellinor, Patrick T.] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA. [Krijthe, Bouwe P.; Hofman, Albert; Uitterlinden, Andre G.; Stricker, Bruno H. C.] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands. [Krijthe, Bouwe P.; Hofman, Albert; Uitterlinden, Andre G.; Stricker, Bruno H. C.] NCHA, Rotterdam, Netherlands. [Magnani, Jared W.; Benjamin, Emelia J.] Boston Univ, Sch Med, Dept Med, Cardiol Sect, Boston, MA 02118 USA. [Gollob, Michael H.] Univ Ottawa, Inst Heart, Arrhythmia Res Lab, Ottawa, ON, Canada. [Tsunoda, Tatsuhiko] RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Yokohama, Kanagawa, Japan. [Mueller-Nurasyid, Martina] German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany. [Mueller-Nurasyid, Martina] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany. [Lichtner, Peter] German Res Ctr Environm Hlth, Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany. [Peters, Annette; Kaeaeb, Stefan] Deutsches Zentrum Herz Kreislaufforsch eV DZHK, Partner Site Munich Heart Alliance, Munich, Germany. [Peters, Annette] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany. [Kubo, Michiaki] RIKEN Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa, Japan. [Smith, Jonathan D.] Cleveland Clin, Dept Cellular & Mol Med, Lerner Res Inst, Cleveland, OH 44106 USA. [Psaty, Bruce M.; Smith, Nicholas L.; Heckbert, Susan R.] Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA USA. [Psaty, Bruce M.; Smith, Nicholas L.; Heckbert, Susan R.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Psaty, Bruce M.] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Smith, Nicholas L.] Dept Vet Affairs, Epidemiol Res & Informat Ctr, Off Res & Dev, Seattle, WA USA. [Jukema, Wouter] Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands. [Chasman, Daniel I.; Albert, Christine M.] Harvard Univ, Sch Med, Boston, MA USA. [Chasman, Daniel I.; Albert, Christine M.] Brigham & Womens Hosp, Div Prevent Med, Div Cardiovasc, Boston, MA 02115 USA. [Ebana, Yusuke; Furukawa, Tetsushi] Tokyo Med & Dent Univ, Med Res Inst, Dept Bioinformat Pharmacol, Tokyo, Japan. [MacFarlane, Peter W.] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland. [Harris, Tamara B.] NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, NIH, Bethesda, MD 20892 USA. [Darbar, Dawood] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA. [Doerr, Marcus] Ernst Moritz Arndt Univ Greifswald, Dept Internal Med B, Greifswald, Germany. [Svendsen, Jesper H.] Univ Copenhagen, Dept Clin Med, Fac Hlth Sci, Copenhagen, Denmark. [Uitterlinden, Andre G.; Stricker, Bruno H. C.] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands. [Gudnason, Vilmundur] Iceland Heart Assoc, Res Inst, Kopavogur, Iceland. [Gudnason, Vilmundur] Univ Iceland, Reykjavik, Iceland. [Isobe, Mitsuaki] Tokyo Med & Dent Univ, Dept Cardiovasc Med, Tokyo, Japan. [Malik, Rainer; Dichgans, Martin] Univ Munich, Inst Stroke & Dementia Res, Univ Hosp Munich, Munich, Germany. [Dichgans, Martin] Munich Cluster Syst Neurol SyNergy, Munich, Germany. [Rosand, Jonathan; Ellinor, Patrick T.] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA. [Rosand, Jonathan] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Rosand, Jonathan] Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA. [Benjamin, Emelia J.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. [Benjamin, Emelia J.] Boston Univ, Sch Med, Dept Med, Prevent Med Sect, Boston, MA 02118 USA. [Melander, Olle] Lund Univ, Dept Clin Sci, Malmo, Sweden. [Ford, Ian] Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland. [Liu, Yongmei] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA. [Barnard, John] Cleveland Clin, Dept Quantitat Hlth Sci, Lerner Res Inst, Cleveland, OH 44106 USA. [Stricker, Bruno H. C.] Inspectorate Hlth Care, The Hague, Netherlands. [Stricker, Bruno H. C.] Erasmus MC, Dept Med Informat, Rotterdam, Netherlands. [Tanaka, Toshihiro] Tokyo Med & Dent Univ, Dept Human Genet & Dis Divers, Grad Sch Med & Dent Sci, Tokyo, Japan. RP Kaeaeb, S (reprint author), Univ Munich, Dept Med 1, Univ Hosp Munich, Campus Innenstadt,Ziemssenstr 1, D-80336 Munich, Germany. EM skaab@med.lmu.de RI Krammel, Vera/N-4826-2014; Darbar, Dawood/C-9079-2015; Tsunoda, Tatsuhiko/K-2061-2014; Gudnason, Vilmundur/K-6885-2015; Tanaka, Toshihiro/J-9310-2014; Peters, Annette/A-6117-2011; Kubo, Michiaki/N-7947-2015 OI Krammel, Vera/0000-0002-8273-8396; Darbar, Dawood/0000-0002-4103-5977; Lin, Honghuang/0000-0003-3043-3942; Benjamin, Emelia/0000-0003-4076-2336; Gudnason, Vilmundur/0000-0001-5696-0084; Svendsen, Jesper Hastrup/0000-0001-8466-8515; Tanaka, Toshihiro/0000-0001-6201-9784; FU National Institutes of Health (NIH) [N01-AG-12100]; NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association); Althingi (the Icelandic Parliament); AFNET/KORA S4: German National Genome Research Network [NGFN 01GS0838, 01GR0803, BMBF-01EZ0874, NGFN 01GI0204, 01GR0103, NGFN-2, NGFNPlus 01GS0823, NGFNPlus 01GS0834]; German Federal Ministry of Education and Research (BMBF) [01EZ0874]; German Competence Network on AF (AFNET) [01 GI 0204/N]; Leducq Foundation [07-CVD 03]; BMBF Spitzen cluster personalized medicine m4 [01 EX1021E]; LMU Excellence Initiative [42595-6]; Munich Center of Health Sciences (MC Health) as part of LMUinnovativ; BMBF; State of Bavaria; German Heart Foundation; DZHK (German Center for Cardiovascular Research); BMBF (German Ministry of Education and Research); ARIC: National Heart, Lung, and Blood Institute (NHLBI) [N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022, R01HL087641, R01HL59367, R01HL086694, U10HL054512]; National Human Genome Research Institute [U01HG004402]; NIH [HHSN268200625226C, UL1RR025005, HHSN268200782096C, K23HL114724, T32HL007208, R01HL092577, HL065962, R01HL104156, K24HL105780]; NIH Roadmap for Medical Research; NHLBI [RC1-HL-099452, R01 HL090620, R01 HL111314, HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, HL080295, HL087652, HL105756, N01-HC-25195, R01 HL 068986, R01 HL085251, R01 HL073410, HL 043851, HL69757]; American Heart Association. BioBank Japan [09SDG2280087]; Ministry of Education, Culture, Sports, Science, and Technology, Japan; SENSIN Medical Research Foundation, Japan; Danish National Research Foundation Center for Cardiac Arrhythmia; John and Birthe Meyer Foundation; Research Foundation of the Heart Center Rigshospitalet; Laegernes Forsikringsforening af 1891; Arvid Nilsson Foundation; Director Henrik Ibsens Foundation; Villadsen Family Foundation; stockbroker Henry Hansen and wife Karla Hansen, born Westergaard, Grant; Danish Heart Foundation [07-10-R60-A1815-B573-22398]; NIH/National Center for Research Resources Clinical and Translational Scienece Award [1UL-RR024989]; Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic; Atrial Fibrillation Innovation Center, State of Ohio; National Institute of Neurological Disorders and Stroke; National Institute on Aging (NIA) [AG023629]; National Center for Advancing Translational Sciences, Clinical & Translational Science Institute [UL1TR000124]; National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center [DK063491]; Affymetrix, Inc [N02-HL-6-4278]; Robert Dawson Evans Endowment of the Department of Medicine at the Boston University School of Medicine; Boston Medical Center; NIA [N01AG62101, N01AG62103, N01AG62106, 1R01AG032098-01A1]; Intramural Research Program of the NIH, NIA; Malmo city council; Swedish Heart-Lung foundation; Thorsten Westerstrom Foundation; Swedish Medical Research Council; Medical Faculty of Lund University; Malmo University Hospital; Albert Pahlsson Research Foundation; Crafoord Foundation; Region Skane; Hulda and Conrad Mossfelt Foundation; King Gustaf V and Queen Victoria Fund; Lennart Hanssons Memorial Fund; Wallenberg Foundation; Doris Duke Charitable Foundation Clinical Scientist Development Award [2014105]; American Heart Association Established Investigator Award [13EIA14220013]; Heart and Stroke Foundations of Ontario; Canadian Institutes for Health Research; government of Ontario; Heart and Stroke Foundation of Ontario Clinician-Scientist Award; Bristol-Myers Squibb; Netherlands Heart Foundation [2001 D 032]; Seventh Framework Program of the European Commission [223004]; Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging) [050-060-810]; Erasmus Medical Center and Erasmus University Rotterdam; Netherlands Organization for Scientific Research; Netherlands Organization for Health Research and Development (ZonMw); Research Institute for Diseases in the Elderly; Netherlands Heart Foundation; Ministry of Education, Culture and Science; Ministry of Health Welfare and Sports; European Commission; Municipality of Rotterdam; Netherlands Organization for Scientific Research [175.010.2005.011, 911.03.012]; Netherlands Genomics Initiative/Netherlands Organization for Scientific Research [050-060-810]; Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403]; Ministry of Cultural Affairs; Social Ministry of the Federal State of Mecklenburg-West Pomerania; research project Greifswald Approach to Individualized Medicine; Ministry of Cultural Affairs of the Federal State of Mecklenburg-West Pomerania [03IS2061A]; BMBF [03ZIK012]; Siemens Healthcare, Erlangen, Germany; Federal State of Mecklenburg-West Pomerania; National Cancer Institute [CA 047988]; Donald W. Reynolds Foundation; Fondation Leducq; Amgen; Harris Family Foundation [HL-093613]; Vascular Dementia Research Foundation; National Institute of Neurological Disorders and Stroke [U01-NS069208] FX This work was funded by the following: AGES: National Institutes of Health (NIH) contract N01-AG-12100, NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). AFNET/KORA S4: German National Genome Research Network NGFN 01GS0838, 01GR0803, BMBF-01EZ0874, 01GR0803, NGFN 01GI0204, 01GR0103, NGFN-2, NGFNPlus 01GS0823, and NGFNPlus 01GS0834; German Federal Ministry of Education and Research (BMBF) 01EZ0874; German Competence Network on AF (AFNET) 01 GI 0204/N; Leducq Foundation 07-CVD 03, BMBF Spitzen cluster personalized medicine m4 (01 EX1021E), LMU Excellence Initiative (42595-6); Munich Center of Health Sciences (MC Health) as part of LMUinnovativ. The KORA platform is funded by the BMBF and by the State of Bavaria. Dr Sinner was supported by the German Heart Foundation. Dr Kaab was supported by the DZHK (German Center for Cardiovascular Research) and BMBF (German Ministry of Education and Research). ARIC: National Heart, Lung, and Blood Institute (NHLBI) contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022, R01HL087641, R01HL59367, R01HL086694 and U10HL054512; National Human Genome Research Institute contract U01HG004402; and NIH contract HHSN268200625226C. We thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by grant UL1RR025005, a component of the NIH and NIH Roadmap for Medical Research. Additional support was provided by grants RC1-HL-099452 from the NHLBI and 09SDG2280087 from the American Heart Association. BioBank Japan: This study was supported by the Ministry of Education, Culture, Sports, Science, and Technology, Japan and by SENSIN Medical Research Foundation, Japan. DANFIB: Danish National Research Foundation Center for Cardiac Arrhythmia, the John and Birthe Meyer Foundation, the Research Foundation of the Heart Center Rigshospitalet, Laegernes Forsikringsforening af 1891, the Arvid Nilsson Foundation, and the Director Henrik Ibsens Foundation, the Villadsen Family Foundation, the stockbroker Henry Hansen and wife Karla Hansen, born Westergaard, Grant, and the Danish Heart Foundation (grant 07-10-R60-A1815-B573-22398). Cleveland Clinic: R01 HL090620 and R01 HL111314 from the NHLBI (Drs Chung, Barnard, J. Smith, and Van Wagoner); NIH/National Center for Research Resources Clinical and Translational Scienece Award 1UL-RR024989 (Drs Chung and Van Wagoner); Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic (Dr Chung); Leducq Foundation 07-CVD 03 (Drs Van Wagoner and Chung); Atrial Fibrillation Innovation Center, State of Ohio (Drs Van Wagoner and Chung). CHS: NHLBI contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086, and NHLBI grants HL080295, HL087652, and HL105756 with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through AG023629 from the National Institute on Aging (NIA). A full list of CHS investigators and institutions can be found at http://www.CHS-NHLBI.org. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, Clinical & Translational Science Institute grant UL1TR000124, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center grant DK063491 to the Southern California Diabetes Endocrinology Research Center.; FHS: NHLBI and Boston University School of Medicine based on analyses by Framingham Heart Study investigators participating in the SNP Health Association Resource (SHARe) project. NHLBI's Framingham Heart Study (contract No. N01-HC-25195) and its contract with Affymetrix, Inc for genotyping services (contract No. N02-HL-6-4278). A portion of this research used the Linux Cluster for Genetic Analysis (LinGA-II) funded by the Robert Dawson Evans Endowment of the Department of Medicine at the Boston University School of Medicine and Boston Medical Center. Other support came from 1R01 HL092577 1RO1 HL076784, 1R01 AG028321, Evans Center for Interdisciplinary Biomedical Research ARC on Atrial Fibrillation at Boston University (Benjamin), 6R01-NS 17950, and American Heart Association 09FTF2190028. Health ABC: NIA contracts N01AG62101, N01AG62103, and N01AG62106. The genome-wide association study was funded by NIA grant 1R01AG032098-01A1 to Wake Forest University Health Sciences, and genotyping services were provided by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from the NIH to The Johns Hopkins University, contract No. HHSN268200782096C. This research was supported in part by the Intramural Research Program of the NIH, NIA. HVH: NHLBI R01 HL 068986, R01 HL085251, and R01 HL073410. MAC: The Malmo Diet and Cancer study was made possible by grants from the Malmo city council. Dr J.G. Smith was supported by the Swedish Heart-Lung foundation and the Thorsten Westerstrom Foundation. Dr Melander was supported by the Swedish Heart-Lung Foundation, the Swedish Medical Research Council, the Medical Faculty of Lund University, the Malmo University Hospital, the Albert Pahlsson Research Foundation, the Crafoord Foundation, the Region Skane, the Hulda and Conrad Mossfelt Foundation, the King Gustaf V and Queen Victoria Fund, the Lennart Hanssons Memorial Fund, and the Wallenberg Foundation. MGH: Doris Duke Charitable Foundation Clinical Scientist Development Award 2014105 (Dr Lubitz), NIH grants K23HL114724 (Dr Lubitz), T32HL007208 (Dr Tucker), R01HL092577 (Drs Ellinor and Benjamin), HL065962, R01HL104156 and K24HL105780 (Dr Ellinor), and an American Heart Association Established Investigator Award 13EIA14220013 (Ellinor). Ottawa: Heart and Stroke Foundations of Ontario (Dr Gollob), and the Canadian Institutes for Health Research (Dr Gollob). Dr Gollob is supported by the Early Researcher Award program from the government of Ontario and from the Heart and Stroke Foundation of Ontario Clinician-Scientist Award. PROSPER: Supported by an investigator-initiated grant obtained from Bristol-Myers Squibb. Dr Jukema is an Established Clinical Investigator of the Netherlands Heart Foundation (grant 2001 D 032). Support for genotyping was provided by the Seventh Framework Program of the European Commission (grant 223004) and by the Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging grant 050-060-810). RS-I / RS-II: RS-I is supported by the Erasmus Medical Center and Erasmus University Rotterdam; the Netherlands Organization for Scientific Research; The Netherlands Organization for Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly; The Netherlands Heart Foundation; the Ministry of Education, Culture and Science; the Ministry of Health Welfare and Sports; the European Commission; and the Municipality of Rotterdam. Support for genotyping was provided by the Netherlands Organization for Scientific Research (175.010.2005.011, 911.03.; 012) and Research Institute for Diseases in the Elderly. This study was supported by the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research project No. 050-060-810. SHIP: SHIP is part of the Community Medicine Research Network of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs, and the Social Ministry of the Federal State of Mecklenburg-West Pomerania. This work supported partly by the research project Greifswald Approach to Individualized Medicine, which is funded by the BMBF and the Ministry of Cultural Affairs of the Federal State of Mecklenburg-West Pomerania (03IS2061A). Generation of genome-wide data has been supported by the BMBF (grant 03ZIK012) and a joint grant from Siemens Healthcare, Erlangen, Germany, and the Federal State of Mecklenburg-West Pomerania. The University of Greifswald is a member of the Center of Knowledge Interchange program of the Siemens AG. WGHS: NHLBI HL 043851 (Buring) and HL69757 (Buring) and National Cancer Institute CA 047988 (Buring), the Donald W. Reynolds Foundation and the Fondation Leducq (Ridker), with collaborative scientific support and funding for genotyping provided by Amgen. AF end-point confirmation was supported by HL-093613 (Dr Albert) and a grant from the Harris Family Foundation (Tedrow). METASTROKE: Dr Dichgans is supported by the Vascular Dementia Research Foundation. Dr Rosand is supported by the National Institute of Neurological Disorders and Stroke U01-NS069208. None of the funding agencies had any role in the study design, data collection or analysis, interpretation of the data, writing of the manuscript, or the decision to submit the manuscript for publication. NR 41 TC 42 Z9 42 U1 0 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD OCT 7 PY 2014 VL 130 IS 15 BP 1225 EP + DI 10.1161/CIRCULATIONAHA.114.009892 PG 48 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AQ8VH UT WOS:000343113800009 PM 25124494 ER PT J AU Killian, NJ Buffalo, EA AF Killian, Nathaniel J. Buffalo, Elizabeth A. TI Distinct frequencies mark the direction of cortical communication SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Editorial Material ID GAMMA; COHERENCE; CORTEX; MONKEY; SYNCHRONIZATION; OSCILLATIONS; CONNECTIONS; RHYTHMS C1 [Killian, Nathaniel J.] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA. [Buffalo, Elizabeth A.] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA. [Buffalo, Elizabeth A.] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA. RP Buffalo, EA (reprint author), Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA. EM ebuffalo@uw.edu OI Killian, Nathaniel/0000-0002-4546-0516 NR 18 TC 0 Z9 0 U1 0 U2 5 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 7 PY 2014 VL 111 IS 40 BP 14316 EP 14317 DI 10.1073/pnas.1416138111 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ2QU UT WOS:000342633900021 PM 25267647 ER PT J AU Lynes, MD Tseng, YH AF Lynes, Matthew D. Tseng, Yu-Hua TI Unwiring the transcriptional heat circuit SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Editorial Material ID B-CELL FACTOR; ADIPOCYTE DIFFERENTIATION; GENE-EXPRESSION; WHITE FAT; BROWN-FAT; EBF2; ADIPOGENESIS; COLLIER; MUSCLE; MOUSE C1 [Lynes, Matthew D.; Tseng, Yu-Hua] Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02215 USA. RP Tseng, YH (reprint author), Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02215 USA. EM yu-hua.tseng@joslin.harvard.edu FU NIDDK NIH HHS [P30 DK036836, T32DK007260, P30DK036836, R01 DK077097, R01DK077097, F32 DK102320, F32DK102320, T32 DK007260] NR 20 TC 1 Z9 1 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 7 PY 2014 VL 111 IS 40 BP 14318 EP 14319 DI 10.1073/pnas.1416145111 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ2QU UT WOS:000342633900022 PM 25261553 ER PT J AU Boucher, J Charalambous, M Zarse, K Mori, MA Kleinridders, A Ristow, M Ferguson-Smith, AC Kahn, CR AF Boucher, Jeremie Charalambous, Marika Zarse, Kim Mori, Marcelo A. Kleinridders, Andre Ristow, Michael Ferguson-Smith, Anne C. Kahn, C. Ronald TI Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE transcriptional control; diabetes; developmental control ID MOUSE-CHROMOSOME 12; NONCODING RNAS; STEM-CELL; METHYLATION; MECHANISMS; CLUSTERS; DOMAIN; DISRUPTION; TISSUES; OBESITY AB In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show that cells lacking both IRs and IGF1Rs exhibit a major decrease in expression of multiple imprinted genes and microRNAs, which is partially mimicked by inactivation of IR alone in mouse embryonic fibroblasts or in vivo in brown fat in mice. This down-regulation is accompanied by changes in DNA methylation of differentially methylated regions related to these loci. Different from a loss of imprinting pattern, loss of IR and IGF1R causes down-regulated expression of both maternally and paternally expressed imprinted genes and microRNAs, including neighboring reciprocally imprinted genes. Thus, the unoccupied IR and IGF1R generate previously unidentified signals that control expression of imprinted genes and miRNAs through transcriptional mechanisms that are distinct from classical imprinting control. C1 [Boucher, Jeremie; Zarse, Kim; Mori, Marcelo A.; Kleinridders, Andre; Kahn, C. Ronald] Brigham & Womens Hosp, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02215 USA. [Boucher, Jeremie; Zarse, Kim; Mori, Marcelo A.; Kleinridders, Andre; Kahn, C. Ronald] Brigham & Womens Hosp, Dept Med, Boston, MA 02215 USA. [Boucher, Jeremie; Zarse, Kim; Mori, Marcelo A.; Kleinridders, Andre; Kahn, C. Ronald] Harvard Univ, Sch Med, Boston, MA 02215 USA. [Charalambous, Marika; Ferguson-Smith, Anne C.] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 1TN, England. [Zarse, Kim; Ristow, Michael] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Energy Metab Lab, CH-8092 Zurich, Switzerland. RP Kahn, CR (reprint author), Brigham & Womens Hosp, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02215 USA. EM c.ronald.kahn@joslin.harvard.edu RI Ristow, Michael/O-9858-2014; Zarse, Kim/D-2133-2016; OI Ristow, Michael/0000-0003-2109-2453; Zarse, Kim/0000-0003-2542-6123; Charalambous, Marika/0000-0002-1684-5783 FU National Institutes of Health [DK31036, DK82659]; Diabetes Endocrinology Research Center [DK34834]; American Diabetes Association mentor-based award; Mary K. Iacocca Professorship; FP7 EpigeneSys; Medical Research Council; Wellcome Trust; European Foundation for the Study of Diabetes FX We thank Mary Elizabeth Patti for helpful discussions and Katie Hughes for assistance with the microarray analysis. This work was supported by National Institutes of Health Grants DK31036 and DK82659; Diabetes Endocrinology Research Center Grant DK34834, an American Diabetes Association mentor-based award, and the Mary K. Iacocca Professorship. A.C.F.-S. and M.C. are supported by FP7 EpigeneSys and grants from the Medical Research Council and Wellcome Trust. K.Z. was supported by an Albert Renold Fellowship of the European Foundation for the Study of Diabetes. NR 45 TC 8 Z9 8 U1 1 U2 15 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 7 PY 2014 VL 111 IS 40 BP 14512 EP 14517 DI 10.1073/pnas.1415475111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ2QU UT WOS:000342633900055 PM 25246545 ER PT J AU Katawera, V Siedner, M Boum, Y AF Katawera, Victoria Siedner, Mark Boum, Yap, II TI Evaluation of the modified colorimetric resazurin microtiter plate-based antibacterial assay for rapid and reliable tuberculosis drug susceptibility testing SO BMC MICROBIOLOGY LA English DT Article ID NITRATE REDUCTASE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; RESISTANCE; INDICATOR AB Background: The resazurin microtiter assay (classic REMA), a colorimetric liquid culture-based drug susceptibility assay for Mycobacterium tuberculosis (MTB), has been endorsed by the World Health Organization. The assay requires 8-16 days to obtain results, delaying management of drug resistant tuberculosis patients. A modified REMA which allows results in as little as 24 hours for bacterial strains, has been developed and validated using Staphylococcus aureus, but has not yet been evaluated for MTB. Therefore we assessed the performance of the modified REMA for rifampicin (RIF) and isoniazid (INH) susceptibility, using the classic REMA as the reference standard. We also compared simplicity (from the technicians' point of view), time taken to obtain results (rank-sum testing), specificity and Kappa statistics of the two methods. Results: The modified REMA, which is a one-step procedure, was found to be simpler to perform and results were obtained in a significantly shorter time (5 versus 9 days, p < 0.0001) compared to the classic REMA due to addition of indicator and strain at the same time. The specificity of the modified REMA was low {46.8% (35.5% - 58.4%) for RIF and 13.9% (7.2% - 23.5%) for INH}. Kappa statistics were 16.0% for RIF and 2.0% for INH. Low specificity and kappa statistics are due to indicator reduction by the strains before complete drug activity. Conclusion: Although modified REMA is faster and simpler compared to classic REMA, it is not reliable for MTB drug susceptibility testing. C1 [Katawera, Victoria; Boum, Yap, II] Mbarara Res Ctr, Epictr, Mbarara, Uganda. [Katawera, Victoria; Boum, Yap, II] Mbarara Univ Sci & Technol, Mbarara, Uganda. [Siedner, Mark] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Siedner, Mark] Harvard Univ, Sch Med, Boston, MA 02115 USA. RP Boum, Y (reprint author), Mbarara Res Ctr, Epictr, Mbarara, Uganda. EM yap.boum@epicentre.msf.org OI Siedner, Mark/0000-0003-3506-842X FU Belgian Embassy Development Agency, Uganda; The Council for Frontiers of Knowledge (The CFK) FX This work was supported by Belgian Embassy Development Agency, Uganda and The Council for Frontiers of Knowledge (The CFK). NR 12 TC 1 Z9 1 U1 1 U2 13 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD OCT 7 PY 2014 VL 14 AR 259 DI 10.1186/s12866-014-0259-6 PG 4 WC Microbiology SC Microbiology GA AQ4QQ UT WOS:000342783600001 PM 25287132 ER PT J AU Manoach, DS Demanuele, C Wamsley, EJ Vangel, M Montrose, DM Miewald, J Kupfer, D Buysse, D Stickgold, R Keshavan, MS AF Manoach, Dara S. Demanuele, Charmaine Wamsley, Erin J. Vangel, Mark Montrose, Debra M. Miewald, Jean Kupfer, David Buysse, Daniel Stickgold, Robert Keshavan, Matcheri S. TI Sleep spindle deficits in antipsychotic-naive early course schizophrenia and in non-psychotic first-degree relatives SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Article DE sleep; sleep spindles; schizophrenia; cognition; IQ; polysomnography; endophenotype; relatives ID MEMORY CONSOLIDATION; PSYCHIATRIC-DISORDERS; STAGE-2 SLEEP; DEPRIVATION; PERFORMANCE; PSYCHOSIS; ATTENTION; ADULTS; YOUNG; SLOW AB Introduction: Chronic medicated patients with schizophrenia have marked reductions in sleep spindle activity and a correlated deficit in sleep-dependent memory consolidation. Using archival data, we investigated whether antipsychotic-naive early course patients with schizophrenia and young non-psychotic first-degree relatives of patients with schizophrenia also show reduced sleep spindle activity and whether spindle activity correlates with cognitive function and symptoms. Method: Sleep spindles during Stage 2 sleep were compared in antipsychotic-naive adults newly diagnosed with psychosis, young non-psychotic first-degree relatives of schizophrenia patients and two samples of healthy controls matched to the patients and relatives. The relations of spindle parameters with cognitive measures and symptom ratings were examined. Results: Early course schizophrenia patients showed significantly reduced spindle activity relative to healthy controls and to early course patients with other psychotic disorders. Relatives of schizophrenia patients also showed reduced spindle activity compared with controls. Reduced spindle activity correlated with measures of executive function in early course patients, positive symptoms in schizophrenia and IQ estimates across groups. Conclusions: Like chronic medicated schizophrenia patients, antipsychotic-naive early course schizophrenia patients and young non-psychotic relatives of individuals with schizophrenia have reduced sleep spindle activity. These findings indicate that the spindle deficit is not an antipsychotic side-effect or a general feature of psychosis. Instead, the spindle deficit may predate the onset of schizophrenia, persist throughout its course and be an endophenotype that contributes to cognitive dysfunction. C1 [Manoach, Dara S.; Demanuele, Charmaine] Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA. [Manoach, Dara S.; Demanuele, Charmaine; Vangel, Mark] Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA. [Manoach, Dara S.; Demanuele, Charmaine; Wamsley, Erin J.; Vangel, Mark; Stickgold, Robert; Keshavan, Matcheri S.] Harvard Univ, Sch Med, Boston, MA USA. [Wamsley, Erin J.; Stickgold, Robert; Keshavan, Matcheri S.] Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA 02215 USA. [Montrose, Debra M.; Miewald, Jean; Kupfer, David; Buysse, Daniel; Keshavan, Matcheri S.] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA USA. RP Manoach, DS (reprint author), Massachusetts Gen Hosp Charlestown Navy Yard, 149 13th St,Room 1-111, Charlestown, MA 02129 USA. EM dara@nmr.mgh.harvard.edu FU [K24 MH099421]; [RO1 MH092638]; [RO1 MH048832]; [R21 MH098171]; [RO1 MH45203]; [K02 01180] FX K24 MH099421, RO1 MH092638 (Dara S. Manoach); RO1 MH048832, RO1 MH092638; R21 MH098171 (Robert Stickgold); RO1 MH45203, K02 01180 (Matcheri S. Keshavan). NR 82 TC 22 Z9 23 U1 2 U2 15 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD OCT 7 PY 2014 VL 8 AR 762 DI 10.3389/fnhum.2014.00762 PG 16 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA AQ2KD UT WOS:000342613300001 PM 25339881 ER PT J AU Frey, K Unholtz, D Bauer, J Debus, J Min, CH Bortfeld, T Paganetti, H Parodi, K AF Frey, K. Unholtz, D. Bauer, J. Debus, J. Min, C. H. Bortfeld, T. Paganetti, H. Parodi, K. TI Automation and uncertainty analysis of a method for in-vivo range verification in particle therapy SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article DE range verification; PET; proton therapy ID BEAM PET DATA; PROTON THERAPY; FEASIBILITY AB We introduce the automation of the range difference calculation deduced from particle-irradiation induced beta(+)-activity distributions with the so-called most-likely-shift approach, and evaluate its reliability via the monitoring of algorithm-and patient-specific uncertainty factors. The calculation of the range deviation is based on the minimization of the absolute profile differences in the distal part of two activity depth profiles shifted against each other. Depending on the workflow of positron emission tomography (PET)-based range verification, the two profiles under evaluation can correspond to measured and simulated distributions, or only measured data from different treatment sessions. In comparison to previous work, the proposed approach includes an automated identification of the distal region of interest for each pair of PET depth profiles and under consideration of the planned dose distribution, resulting in the optimal shift distance. Moreover, it introduces an estimate of uncertainty associated to the identified shift, which is then used as weighting factor to 'red flag' problematic large range differences. Furthermore, additional patient-specific uncertainty factors are calculated using available computed tomography (CT) data to support the range analysis. The performance of the new method for in-vivo treatment verification in the clinical routine is investigated with in-room PET images for proton therapy as well as with offline PET images for proton and carbon ion therapy. The comparison between measured PET activity distributions and predictions obtained byMonte Carlo simulations or measurements from previous treatment fractions is performed. For this purpose, a total of 15 patient datasets were analyzed, which were acquired at Massachusetts General Hospital and Heidelberg Ion-Beam Therapy Center with in-room PET and offline PET/CT scanners, respectively. Calculated range differences between the compared activity distributions are reported in a 2D map in beam-eye-view. In comparison to previously proposed approaches, the new most-likely-shift method shows more robust results for assessing in-vivo the range from strongly varying PET distributions caused by differing patient geometry, ion beam species, beam delivery techniques, PET imaging concepts and counting statistics. The additional visualization of the uncertainties and the dedicated weighting strategy contribute to the understanding of the reliability of observed range differences and the complexity in the prediction of activity distributions. The proposed method promises to offer a feasible technique for clinical routine of PET-based range verification. C1 [Frey, K.; Parodi, K.] Univ Munich, Munich, Germany. [Unholtz, D.; Bauer, J.; Debus, J.] Heidelberg Ion Beam Therapy Ctr, Heidelberg, Germany. [Unholtz, D.; Bauer, J.; Debus, J.; Parodi, K.] Univ Clin, Dept Radiat Oncol, Heidelberg, Germany. [Min, C. H.; Bortfeld, T.; Paganetti, H.] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. RP Frey, K (reprint author), Univ Munich, Munich, Germany. EM Katia.Parodi@physik.uni-muenchen.de FU National Cancer Institute [P01 CA21239] FX CHM, TB, and HP were supported by a grant by the National Cancer Institute (P01 CA21239). We would like to thank members of the Department of Radiology (Drs G El Fakhri, X Zhu, K Grogg) and Department of Radiation Oncology (Dr B Winey) at the Massachusetts General Hospital for their efforts in obtaining the patient data as well as Dr H Shih (Massachusetts General Hospital) for referring patients to this study. Similarly, we acknowledge the clinical support of the Department of Radiation Oncology (especially Drs S Combs, K Herfarth, T Welzel) at the Heidelberg University Hospital. The human subject studies at both clinical institutions were approved by internal review protocol (IRB). Finally, the authors would like to thank the colleagues from Heidelberg Ion-Beam Therapy Center and University Hospital, Germany, Christopher Kurz and from Fraunhofer MEVIS in Bremen, Germany, especially A Kohn and S Wirtz, for their support. NR 22 TC 18 Z9 18 U1 0 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-9155 EI 1361-6560 J9 PHYS MED BIOL JI Phys. Med. Biol. PD OCT 7 PY 2014 VL 59 IS 19 BP 5903 EP 5919 DI 10.1088/0031-9155/59/19/5903 PG 17 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA AP8VG UT WOS:000342356800019 PM 25211629 ER PT J AU Chae, Y Lee, IS Jung, WM Chang, DS Napadow, V Lee, H Park, HJ Wallraven, C AF Chae, Younbyoung Lee, In-Seon Jung, Won-Mo Chang, Dong-Seon Napadow, Vitaly Lee, Hyejung Park, Hi-Joon Wallraven, Christian TI Decreased Peripheral and Central Responses to Acupuncture Stimulation following Modification of Body Ownership SO PLOS ONE LA English DT Article ID SHAM ACUPUNCTURE; PREMOTOR CORTEX; RUBBER HAND; HUMAN BRAIN; FMRI; NEEDLE; PAIN; SENSATION; FEEL; INTEROCEPTION AB Acupuncture stimulation increases local blood flow around the site of stimulation and induces signal changes in brain regions related to the body matrix. The rubber hand illusion (RHI) is an experimental paradigm that manipulates important aspects of bodily self-awareness. The present study aimed to investigate how modifications of body ownership using the RHI affect local blood flow and cerebral responses during acupuncture needle stimulation. During the RHI, acupuncture needle stimulation was applied to the real left hand while measuring blood microcirculation with a LASER Doppler imager (Experiment 1, N = 28) and concurrent brain signal changes using functional magnetic resonance imaging (fMRI; Experiment 2, N = 17). When the body ownership of participants was altered by the RHI, acupuncture stimulation resulted in a significantly lower increase in local blood flow (Experiment 1), and significantly less brain activation was detected in the right insula (Experiment 2). This study found changes in both local blood flow and brain responses during acupuncture needle stimulation following modification of body ownership. These findings suggest that physiological responses during acupuncture stimulation can be influenced by the modification of body ownership. C1 [Chae, Younbyoung; Jung, Won-Mo; Wallraven, Christian] Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea. [Chae, Younbyoung; Lee, In-Seon; Lee, Hyejung; Park, Hi-Joon] Kyung Hee Univ, Acupuncture & Meridian Sci Res Ctr, Coll Korean Med, Seoul, South Korea. [Chang, Dong-Seon] Max Planck Inst Biol Cybernet, Dept Human Percept Cognit & Act, D-72076 Tubingen, Germany. [Napadow, Vitaly] Harvard Univ, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Sch Med, Charlestown, MA USA. [Napadow, Vitaly] Kyung Hee Univ, Dept Biomed Engn, Yongin, South Korea. RP Chae, Y (reprint author), Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea. EM ybchae@khu.ac.kr; wallraven@korea.ac.kr OI Chang, Dong-Seon/0000-0003-4562-1321 FU NCCIH NIH HHS [P01-AT006663,, R01-AT005280, R01-AT007550]; NIAMS NIH HHS [R01-AR064367] NR 51 TC 6 Z9 6 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 6 PY 2014 VL 9 IS 10 AR e109489 DI 10.1371/journal.pone.0109489 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AU6XC UT WOS:000345743700069 PM 25285620 ER PT J AU Rana, KD Vaina, LM AF Rana, Kunjan D. Vaina, Lucia M. TI Functional Roles of 10 Hz Alpha-Band Power Modulating Engagement and Disengagement of Cortical Networks in a Complex Visual Motion Task SO PLOS ONE LA English DT Article ID FRONTAL EYE-FIELD; SURFACE-BASED ANALYSIS; SPATIAL ATTENTION; OBJECT MOVEMENT; WORKING-MEMORY; INTEGRATIVE THEORY; COORDINATE SYSTEM; MOVING OBSERVERS; PARIETAL CORTEX; CEREBRAL-CORTEX AB Alpha band power, particularly at the 10 Hz frequency, is significantly involved in sensory inhibition, attention modulation, and working memory. However, the interactions between cortical areas and their relationship to the different functional roles of the alpha band oscillations are still poorly understood. Here we examined alpha band power and the cortico-cortical interregional phase synchrony in a psychophysical task involving the detection of an object moving in depth by an observer in forward self-motion. Wavelet filtering at the 10 Hz frequency revealed differences in the profile of cortical activation in the visual processing regions (occipital and parietal lobes) and in the frontoparietal regions. The alpha rhythm driving the visual processing areas was found to be asynchronous with the frontoparietal regions. These findings suggest a decoupling of the 10 Hz frequency into separate functional roles: sensory inhibition in the visual processing regions and spatial attention in the frontoparietal regions. C1 [Rana, Kunjan D.; Vaina, Lucia M.] Boston Univ, Dept Biomed Engn, Brain & Vis Res Lab, Boston, MA 02215 USA. [Vaina, Lucia M.] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA. [Vaina, Lucia M.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. RP Vaina, LM (reprint author), Boston Univ, Dept Biomed Engn, Brain & Vis Res Lab, Boston, MA 02215 USA. EM vaina@bu.edu FU National Institutes of Health (NIH) [R01NS064100]; Computational Neuroscience Training Grant [T90DA032484] FX This work was supported by National Institutes of Health (NIH) Grant R01NS064100 to LMV and the Computational Neuroscience Training Grant, T90DA032484, "Training in computational neuroscience: Integrating experiment, theory, and technology" to KDR. MEG data was acquired at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, using resources provided by the Center for Functional Neuroimaging Technologies, P41EB015896, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 75 TC 3 Z9 3 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 6 PY 2014 VL 9 IS 10 AR e107715 DI 10.1371/journal.pone.0107715 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AU6XC UT WOS:000345743700009 PM 25285560 ER PT J AU Schimmer, AD Raza, A Carter, TH Claxton, D Erba, H DeAngelo, DJ Tallman, MS Goard, C Borthakur, G AF Schimmer, Aaron D. Raza, Azra Carter, Thomas H. Claxton, David Erba, Harry DeAngelo, Daniel J. Tallman, Martin S. Goard, Carolyn Borthakur, Gautam TI A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3-or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia SO PLOS ONE LA English DT Article ID CHRONIC LYMPHOCYTIC-LEUKEMIA; PAN-BCL-2 FAMILY ANTAGONIST; BCL-2; APOPTOSIS; GX15-070; INHIBITION; CELLS; MCL-1; MALIGNANCIES; NAVITOCLAX AB Purpose: An open-label phase I/II study of single-agent obatoclax determined a maximum tolerated dose (MTD) and schedule, safety, and efficacy in older patients (>= 70 yr) with untreated acute myeloid leukemia (AML). Experimental Design: Phase I evaluated the safety of obatoclax infused for 3 hours on 3 consecutive days (3 hx3 d) in 2-week cycles. Initial obatoclax dose was 30 mg/day (3 hx3 d; n = 3). Obatoclax was increased to 45 mg/day (3 hx3 d) if <= 1 patient had a dose-limiting toxicity (DLT) and decreased to 20 mg/day (3 hx3 d) if DLT occurred in >= 2 patients. In the phase II study, 12 patients were randomized to receive obatoclax at the dose identified during phase I (3 hx3 d) or 60 mg/day administered by continuous infusion over 24 hours for 3 days (24 hx3 d) to determine the morphologic complete response rate. Results: In phase I, two of three patients receiving obatoclax 30 mg/day (3 hx3 d) experienced grade 3 neurologic DLTs (confusion, ataxia, and somnolence). Obatoclax was decreased to 20 mg/day (3 hx3 d). In phase II, no clinically relevant safety differences were observed between the 20 mg/day (3 hx3 d; n = 7) and 60 mg/day (24 hx3 d; n = 5) arms. Neurologic and psychiatric adverse events were most common and were generally transient and reversible. Complete response was not achieved in any patient. Conclusions: Obatoclax 20 mg/day was the MTD (3 hx3 d) in older patients with AML. In the schedules tested, single-agent obatoclax was not associated with an objective response. Evaluation in additional subgroups or in combination with other chemotherapy modalities may be considered for future study. C1 [Schimmer, Aaron D.; Goard, Carolyn] Princess Margaret Canc Ctr, Toronto, ON, Canada. [Raza, Azra] Columbia Univ, Med Ctr, New York, NY USA. [Carter, Thomas H.] Univ Iowa, Iowa City, IA USA. [Claxton, David] Penn State, Hershey, PA USA. [Erba, Harry] Univ Alabama Birmingham, Birmingham, AL USA. [DeAngelo, Daniel J.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Tallman, Martin S.] Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY USA. [Borthakur, Gautam] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. RP Schimmer, AD (reprint author), Princess Margaret Canc Ctr, Toronto, ON, Canada. EM aaron.schimmer@utoronto.ca FU Gemin X Pharmaceuticals, Inc; Cephalon, Inc. FX The study that is the subject of this manuscript was sponsored by Gemin X Pharmaceuticals, Inc., which was acquired by Cephalon, Inc., a wholly-owned subsidiary of Teva Pharmaceutical Industries, Ltd (TEVA). The development and publication of this manuscript has been financially supported by TEVA. Employees of TEVA were actively involved in the development of the manuscript, including providing data as well as review and comment of manuscript drafts. Powered 4 Significance LLC was contracted by TEVA to provide medical writing assistance in preparing an initial draft of the manuscript and editorial assistance. NR 32 TC 9 Z9 11 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 6 PY 2014 VL 9 IS 10 AR e108694 DI 10.1371/journal.pone.0108694 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AU6XC UT WOS:000345743700029 PM 25285531 ER PT J AU Litz, BT AF Litz, Brett T. TI Resilience in the aftermath of war trauma: a critical review and commentary SO INTERFACE FOCUS LA English DT Review DE resilience; military trauma; indicated prevention; post-traumatic stress disorder ID POSTTRAUMATIC-STRESS-DISORDER; COMPREHENSIVE-SOLDIER-FITNESS; DELAYED-ONSET PTSD; DEPRESSIVE SYMPTOMS; FUTURE-DIRECTIONS; MENTAL-DISORDERS; MILITARY; PEACEKEEPERS; PREVENTION; VETERANS AB The resilience construct has received a great deal of attention as a result of the long wars in Iraq and Afghanistan. The discourse about resilience, especially the promise of promoting it and mitigating risk for serious post-traumatic negative outcomes among service members and veterans, is hopeful and encouraging. Remarkably, most service members exposed to horrific war trauma are not incapacitated by the experience. Yet, resilience is elusive and fleeting for many veterans of war. In this paper, I address some of the complexities about resilience in the context of exposure to war stressors and I offer some assumptions and heuristics that stem from my involvement in the dialogue about resilience and from experiences helping prevent post-traumatic stress disorder among active-duty service members with military trauma. My goal is to use my observations and applied experiences as an instructive context to raise critical questions for the field about resilience in the face of traumatic life-events. C1 [Litz, Brett T.] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. [Litz, Brett T.] Boston Univ, Dept Psychol, Boston, MA 02215 USA. [Litz, Brett T.] Boston Univ, Dept Psychiat, Boston, MA 02215 USA. RP Litz, BT (reprint author), VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. EM brett.litz@va.gov NR 40 TC 1 Z9 1 U1 2 U2 16 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 2042-8898 EI 2042-8901 J9 INTERFACE FOCUS JI Interface Focus PD OCT 6 PY 2014 VL 4 IS 5 AR 20140008 DI 10.1098/rsfs.2014.0008 PG 10 WC Biology SC Life Sciences & Biomedicine - Other Topics GA AS8AM UT WOS:000344472900003 PM 25285196 ER PT J AU Gale, EM Mukherjee, S Liu, C Loving, GS Caravan, P AF Gale, Eric M. Mukherjee, Shreya Liu, Cynthia Loving, Galen S. Caravan, Peter TI Structure-Redox-Relaxivity Relationships for Redox Responsive Manganese-Based Magnetic Resonance Imaging Probes SO INORGANIC CHEMISTRY LA English DT Article ID MRI CONTRAST AGENTS; 7-COORDINATE MN(II) COMPLEXES; HYPERFINE COUPLING-CONSTANTS; HUMAN SERUM-ALBUMIN; IN-VIVO; WATER-EXCHANGE; OXIDATIVE STRESS; MN2+ COMPLEXES; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE AB A library of 10 Mn-containing complexes capable of switching reversibly between the Mn(II) and Mn(III) oxidation states was prepared and evaluated for potential usage as MRI reporters of tissue redox activity. We synthesized N-(2-hydroxybenzy1)-N,N',N'-ethylenediaminetriacetic acid (HBET) and N-(2-hydroxybenzyl-N,N',N'-trans-1,2-cyclohexylenediaminetriacetic acid (CyHBET) ligands functionalized (-H, -OMe, -NO2) at the 5-position of the aromatic ring. The Mn(II) complexes of all ligands and the Mn(11) complexes of the 5-H and 5-NO2 functionalized ligands were synthesized and isolated, but the Mn(III) complexes with the 5-OMe functionalized ligands were unstable. H-1 relaxivity of the 10 isolable complexes was measured at pH 7.4 and 37 degrees C, 1.4 T. Thermodynamic stability, pH-dependent complex speciation, hydration state, water exchange kinetics of the Mn(B) complexes, and pseudo-first order reduction kinetics of the Mn(III) complexes were studied using a combination of pH-potentiometry, UV-vis spectroscopy, and H-1 and O-17 NMR measurements. The effects of ligand structural and electronic modifications on the Mn(II/III) redox couple were studied by cyclic voltammetry. The Mn(II) complexes are potent relaxation agents as compared to the corresponding Mn(III) species with [Mn-II(CyHBET)(H2O)](2-) exhibiting a 7.5-fold higher relaxivity (3.3 mM(-1) s(-1)) than the oxidized form (0.4 mM(-1) s(-1)). At pH 7.4, Mn(II) exists as a mixture of fully deprotonated (ML) and monoprotonated (HML) complexes and Mn(II) complex stability decreases as the ligands become more electron-releasing (pMn for 10 mu M [Mn-II(CyHBET-R'(H2O)](2-) decreases from 7.6 to 6.2 as R' goes from -NO2 to -OMe, respectively). HML speciation increases as the electron-releasing nature of the phenolato-O donor increases. The presence of a water coligand is maintained upon conversion from HML to ML, but the water exchange rate of ML is faster by up to 2 orders of magnitude (kin for H[Mn-II(CyHBET)(H2O)](-) and [Mn-II(CyHBET)(H2O)](2-) are 1.2 x 10(8) and 1.0 x 10(10) s(-1), respectively). The Mn(II/III) redox potential can be tuned over a range of 0.30 V (E-1/2= 0.27-0.57 V) through electronic modifications to the 5-substituent of the aromatic ligand component. However, care must be taken in tuning the ligand electronics to avoid Mn(II)-ligand autoredox. Taken together, these results serve to establish criteria for optimizing Mn(III) versus Mn(II) relaxivity differentials, complex stability, and Mn(II/III) redox potential. C1 [Gale, Eric M.; Mukherjee, Shreya; Liu, Cynthia; Loving, Galen S.; Caravan, Peter] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging,Dept Radi, Charlestown, MA 02129 USA. RP Caravan, P (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging,Dept Radi, 149 Thirteenth St,Suite 2301, Charlestown, MA 02129 USA. EM caravan@nmr.mgh.harvard.edu FU National Cancer Institute [CA161221, CA009502]; National Center for Research Resources; Office of the Director [RR14075, OD010650] FX This work was supported by grants from the National Cancer Institute (CA161221 to P.C. and a T32 postdoctoral fellowship to E.M.G., CA009502) and instrumentation funded by the National Center for Research Resources and the Office of the Director (RR14075, OD010650). We thank Anna Moore for access to a UV-vis spectrophotometer. We thank Nick Rotile and Iliyana Atanasova for assistance with MRI scans. NR 89 TC 12 Z9 12 U1 5 U2 49 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0020-1669 EI 1520-510X J9 INORG CHEM JI Inorg. Chem. PD OCT 6 PY 2014 VL 53 IS 19 BP 10748 EP 10761 DI 10.1021/ic502005u PG 14 WC Chemistry, Inorganic & Nuclear SC Chemistry GA AQ5NV UT WOS:000342856800093 PM 25226090 ER PT J AU Uribe-Patarroyo, N Villiger, M Bouma, BE AF Uribe-Patarroyo, Nestor Villiger, Martin Bouma, Brett E. TI Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography SO OPTICS EXPRESS LA English DT Article ID DYNAMIC LIGHT-SCATTERING; BLOOD-FLOW-VELOCITY; QUANTIFICATION; ANGIOGRAPHY; ULTRASOUND; RESOLUTION; SIGNALS AB Intensity-based techniques in optical coherence tomography (OCT), such as those based on speckle decorrelation, have attracted great interest for biomedical and industrial applications requiring speed or flow information. In this work we present a rigorous analysis of the effects of noise on speckle decorrelation, demonstrate that these effects frustrate accurate speed quantitation, and propose new techniques that achieve quantitative and repeatable measurements. First, we derive the effect of background noise on the speckle autocorrelation function, finding two detrimental effects of noise. We propose a new autocorrelation function that is immune to the main effect of background noise and permits quantitative measurements at high and moderate signal-to-noise ratios. At the same time, this autocorrelation function is able to provide motion contrast information that accurately identifies areas with movement, similar to speckle variance techniques. In order to extend the SNR range, we quantify and model the second effect of background noise on the autocorrelation function through a calibration. By obtaining an explicit expression for the decorrelation time as a function of speed and diffusion, we show how to use our autocorrelation function and noise calibration to measure a flowing liquid. We obtain accurate results, which are validated by Doppler OCT, and demonstrate a very high dynamic range (>600 mm/s) compared to that of Doppler OCT (+/- 25 mm/s). We also derive the behavior for low flows, and show that there is an inherent non-linearity in speed measurements in the presence of diffusion due to statistical fluctuations of speckle. Our technique allows quantitative and robust measurements of speeds using OCT, and this work delimits precisely the conditions in which it is accurate. (C) 2014 Optical Society of America C1 [Uribe-Patarroyo, Nestor; Villiger, Martin; Bouma, Brett E.] Harvard Univ, Sch Med, Wellman Ctr Photomed, Boston, MA 02114 USA. [Uribe-Patarroyo, Nestor; Villiger, Martin; Bouma, Brett E.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bouma, Brett E.] Harvard MIT Program Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Uribe-Patarroyo, N (reprint author), Harvard Univ, Sch Med, Wellman Ctr Photomed, 40 Blossom St, Boston, MA 02114 USA. EM uribepatarroyo.nestor@mgh.harvard.edu FU National Institute of Biomedical Imaging; Bioengineering of the National Institutes of Health [P41 EB015903]; Terumo Corporation; Swiss National Science Foundation FX Research in this publication was supported in part by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health, award P41 EB015903, and by Terumo Corporation. MV was supported by a fellowship from the Swiss National Science Foundation. NR 38 TC 13 Z9 13 U1 0 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 6 PY 2014 VL 22 IS 20 BP 24411 EP 24429 DI 10.1364/OE.22.024411 PG 19 WC Optics SC Optics GA AQ4IE UT WOS:000342757000066 PM 25322018 ER PT J AU Csibi, A Lee, G Yoon, SO Tong, HX Iiter, D Elia, I Fendt, SM Roberts, TM Blenis, J AF Csibi, Alfredo Lee, Gina Yoon, Sang-Oh Tong, Haoxuan Iiter, Didem Elia, Ilaria Fendt, Sarah-Maria Roberts, Thomas M. Blenis, John TI The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the elF4B-Dependent Control of c-Myc Translation SO CURRENT BIOLOGY LA English DT Article ID NOVO PYRIMIDINE SYNTHESIS; SIGNALING PATHWAY; MAMMALIAN TARGET; CELL-GROWTH; MTOR; PROLIFERATION; EXPRESSION; CANCER; S6K1; IDENTIFICATION AB Growth-promoting signaling molecules, including the mammalian target of rapamycin complex 1 (mTORC1), drive the metabolic reprogramming of cancer cells required to support their biosynthetic needs for rapid growth and proliferation [1]. Glutamine is catabolyzed to c-ketoglutarate (alpha KG), a tricarboxylic acid (TCA) cycle intermediate, through two deamination reactions, the first requiring glutaminase (GLS) to generate glutamate and the second occurring via glutamate dehydrogenase (GDH) or transaminases [2]. Activation of the mTORC1 pathway has been shown previously to promote the anaplerotic entry of glutamine to the TCA cycle via GDH. Moreover, mTORC1 activation also stimulates the uptake of glutamine, but the mechanism is unknown [3]. It is generally thought that rates of glutamine utilization are limited by mitochondrial uptake via GLS, suggesting that, in addition to GDH, mTORC1 could regulate GLS. Here we demonstrate that mTORC1 positively regulates GLS and glutamine flux through this enzyme. We show that mTORC1 controls GLS levels through the S6K1-dependent regulation of c-Myc (Myc). Molecularly, S6K1 enhances Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor elF4B, which is critical to unwind its structured 5' untranslated region (5'UTR). Finally, our data show that the pharmacological inhibition of GLS is a promising target in pancreatic cancers expressing low levels of PTEN. C1 [Csibi, Alfredo; Lee, Gina; Yoon, Sang-Oh; Iiter, Didem; Blenis, John] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA. [Tong, Haoxuan; Roberts, Thomas M.] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. [Tong, Haoxuan; Roberts, Thomas M.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Iiter, Didem; Blenis, John] Weill Cornell Med Coll, Meyer Canc Ctr, Dept Pharmacol, New York, NY 10065 USA. [Elia, Ilaria; Fendt, Sarah-Maria] Flemish Inst Biotechnol VIB, Vesalius Res Ctr, B-3000 Leuven, Belgium. [Elia, Ilaria; Fendt, Sarah-Maria] KU Leuven Univ Leuven, Dept Oncol, B-3000 Leuven, Belgium. RP Blenis, J (reprint author), Harvard Univ, Sch Med, Dept Cell Biol, 240 Longwood Ave, Boston, MA 02115 USA. EM job2064@med.cornell.edu FU National Research Foundation of Korea [2012R1A6A3A03039825]; NIH [GM51405, CA46595] FX We thank Greg Hoffman, Sarah Mahoney, Gwen Buel, Sang Gyun Kim, Jeannie Li, Emrah Er, and other members of the J.B. laboratory for critical discussions and technical assistance. We also thank Chi V. Dang and Takashi Tsukamoto (John Hopkins) for providing reagents. We thank Alexandra R. Grassian and Jonathan Coloff (Brugge laboratory-HMS) for assistance with glutamine measurements. We thank Jonathan Hurov and Agios Pharmaceuticals for providing specific antibodies for GLS. A. C. is a LAM Foundation Postdoctoral Fellow. G. L. is a LAM Foundation and Tuberous Sclerosis Alliance Postdoctoral Fellow. G. L. was supported by National Research Foundation of Korea Grant 2012R1A6A3A03039825. J.B. is an Established Investigator of the LAM Foundation. NIH Grants GM51405 and CA46595 provided research support for the J.B. laboratory. NR 28 TC 34 Z9 35 U1 4 U2 25 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0960-9822 EI 1879-0445 J9 CURR BIOL JI Curr. Biol. PD OCT 6 PY 2014 VL 24 IS 19 BP 2274 EP 2280 DI 10.1016/j.cub.2014.08.007 PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA AQ4FB UT WOS:000342747600022 PM 25220053 ER PT J AU Zhu, RL Cho, KS Chen, DF Yang, L AF Zhu Ruilin Cho Kin-Sang Chen Dong Feng Yang Liu TI Ephrin-A2 and-A3 are negative regulators of the regenerative potential of Muller cells SO CHINESE MEDICAL JOURNAL LA English DT Article DE Muller cell; stem cell; retinal regeneration ID RETINAL STEM-CELLS; NEURAL REGENERATION; PROLIFERATION; GLIA; NEUROGENESIS; SURVIVAL; RECEPTOR; INJURY; EYE AB Background In a previous study, we demonstrated that ephrin-A2 and -A3 negatively regulate the growth of neural progenitor cells in the central nervous system. Adult mice deficient in ephrin-A2 and -A3 (A2(-/-)A3(-/-)) displayed active ongoing neurogenesis throughout the brain, and mice deficient in ephrin-A3 alone showed increased proliferation of ciliary epithelium derived retinal stem cells. This study aimed to detect that the increase in proliferation and neurogenic potential of Muller cells is influenced by the absence of ephrin-A2 and -A3. Methods We assessed the retinal and Muller cell expression of ephrin-As and their receptor and neural progenitor cell markers by immunostaining and real-time PCR. We cultured purified primary Muller cells derived from wild-type and A2(-/-)A3(-/-) mice in a defined culture medium that enables trans-differentiation of Muller cells into retinal neurons. To evaluate proliferating Muller cells in vivo, we injected 5'-ethylnyl-2'-deoxiuridine (EdU) intraperitoneally to adult mice. Results Expression of ephrin-A2/A3 and their receptor EphA4 were detected in the retinas of adult mice, with EphA4 expression particularly enriched in Muller cells. Muller cells of A2(-/-)A3(-/-) mice exhibited significantly elevated expression of retinal progenitor cell markers, Pax6 and Chx10, when compared with those from wild-type mice. Moreover, a higher percentage of Muller cells of A2(-/-)A3(-/-) mice trans-differentiated and became recoverin+ and beta-III-tublin+ in the culture than those from wild type mice. Strikingly, an increased number of EdU+ retinal cells was detected in the retinas of adult A2(-/-)A3(-/-) mice as compared with wild-type mice. Conclusions Ephrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Muller cells. Manipulating ephrin-A signaling may thus represent a novel strategy for stimulating neuroregeneration from endogenous progenitors to participate in retinal repair in case of disease or damage. C1 [Zhu Ruilin; Yang Liu] Peking Univ, Dept Ophthalmol, Hosp 1, Beijing 100034, Peoples R China. [Zhu Ruilin; Yang Liu] Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100034, Peoples R China. [Zhu Ruilin; Cho Kin-Sang; Chen Dong Feng] Harvard Univ, Sch Med, Schepens Eye Res Inst, Massachusetts Eye & Ear, Boston, MA USA. [Chen Dong Feng] Boston VA Healthcare Syst, Boston, MA USA. RP Yang, L (reprint author), Peking Univ, Dept Ophthalmol, Hosp 1, Beijing 100034, Peoples R China. EM lucy02114@163.com FU Department of Veterans Affairs [1I01RX000110]; Department of Defense [W81XWH-09-2-0091]; Lion's Foundation; National Natural Science Foundation of China [81170837] FX This study was supported by grants from the Department of Veterans Affairs (1I01RX000110), the Department of Defense (W81XWH-09-2-0091), Lion's Foundation Grants to D.F.C. and K.S.C. and the National Natural Science Foundation of China (No. 81170837). NR 22 TC 2 Z9 2 U1 0 U2 2 PU CHINESE MEDICAL ASSOC PI BEIJING PA 42 DONGSI XIDAJIE, BEIJING 100710, PEOPLES R CHINA SN 0366-6999 J9 CHINESE MED J-PEKING JI Chin. Med. J. PD OCT 5 PY 2014 VL 127 IS 19 BP 3438 EP 3442 DI 10.3760/cma.j.issn.0366-6999.20141130 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AT1XJ UT WOS:000344724000016 PM 25269910 ER PT J AU Krienen, FM Yeo, BTT Buckner, RL AF Krienen, Fenna M. Yeo, B. T. Thomas Buckner, Randy L. TI Reconfigurable task-dependent functional coupling modes cluster around a core functional architecture SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Article DE functional connectivity; resting-state; cortical networks; MRI; intrinsic connectivity ID INFERIOR PREFRONTAL CORTEX; SPONTANEOUS BRAIN ACTIVITY; RESTING-STATE NETWORKS; HUMAN CEREBRAL-CORTEX; WORKING-MEMORY; SENSORY STIMULATION; CONNECTIVITY MRI; ORGANIZATION; PERFORMANCE; COGNITION AB Functional coupling across distributed brain regions varies across task contexts, yet there are stable features. To better understand the range and central tendencies of network configurations, coupling patterns were explored using functional MRI (fMRI) across 14 distinct continuously performed task states ranging from passive fixation to increasingly demanding classification tasks. Mean global correlation profiles across the cortex ranged from 0.69 to 0.82 between task states. Network configurations from both passive fixation and classification tasks similarly predicted task coactivation patterns estimated from meta-analysis of the literature. Thus, even across markedly different task states, central tendencies dominate the coupling configurations. Beyond these shared components, distinct task states displayed significant differences in coupling patterns in response to their varied demands. One possibility is that anatomical connectivity provides constraints that act as attractors pulling network configurations towards a limited number of robust states. Reconfigurable coupling modes emerge as significant modifications to a core functional architecture. C1 [Krienen, Fenna M.; Buckner, Randy L.] Harvard Univ, Dept Psychol, Ctr Brain Sci, Cambridge, MA 02138 USA. [Krienen, Fenna M.; Yeo, B. T. Thomas; Buckner, Randy L.] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA. [Yeo, B. T. Thomas] Natl Univ Singapore, Clin Imaging Res Ctr, Dept Elect & Comp Engn, Singapore 117548, Singapore. [Yeo, B. T. Thomas] Natl Univ Singapore, Singapore Inst Neurotechnol, Singapore 117548, Singapore. [Yeo, B. T. Thomas] Duke NUS Grad Med Sch, Ctr Cognit Neurosci, Singapore, Singapore. [Buckner, Randy L.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. RP Buckner, RL (reprint author), Harvard Univ, Dept Psychol, Ctr Brain Sci, 33 Kirkland St, Cambridge, MA 02138 USA. EM randy_buckner@harvard.edu OI Yeo, B.T. Thomas/0000-0002-0119-3276 FU Ashford Graduate Fellowship Fund; Simons Foundation; Athinoula A. Martinos Center for Biomedical Imaging [P41EB015896, S10RR021110, S10RR023401, S10RR019307]; National University of Singapore FX F.M.K. was supported by the Ashford Graduate Fellowship Fund. Research was supported by the Simons Foundation, the Athinoula A. Martinos Center for Biomedical Imaging (P41EB015896, S10RR021110, S10RR023401 and S10RR019307) and the National University of Singapore Tier 1 grant. NR 82 TC 24 Z9 24 U1 1 U2 3 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8436 EI 1471-2970 J9 PHILOS T R SOC B JI Philos. Trans. R. Soc. B-Biol. Sci. PD OCT 5 PY 2014 VL 369 IS 1653 SU SI AR 20130526 DI 10.1098/rstb.2013.0526 PG 14 WC Biology SC Life Sciences & Biomedicine - Other Topics GA AO9RW UT WOS:000341695200005 ER PT J AU Puertolas, JA Martinez-Morlanes, MJ Teruel, R Martinez-Felipe, A Oral, E Pascual, FJ Ribes, A AF Antonio Puertolas, Jose Jose Martinez-Morlanes, Maria Teruel, Roberto Martinez-Felipe, Alfonso Oral, Ebru Javier Pascual, Francisco Ribes, Amparo TI Dielectric Behavior Induced by Vitamin E and Electron Beam Irradiation in Ultra High Molecular Weight Polyethylene SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE biomaterials; crosslinking; dielectric properties ID RELAXATION; STERILIZATION; COMPOSITES; RADIATION AB Radiation cross-linked ultra high molecular weight polyethylenes (UHMWPEs) have been successfully used as wear resistant bearing surfaces in total joint arthroplasty. A recent development in this field is the incorporation of the antioxidant vitamin E into radiation cross-linked UHMWPE. This study investigates the effects of radiation cross-linking and vitamin E incorporation on the dielectric behavior of UHMWPE. The dielectric relaxations of virgin and 0.1 wt % vitamin E-blended UHMWPE and their irradiated counterparts (up to 300 kGy dose) were investigated. To determine the effect of vitamin E content alone, vitamin E-loaded UHMWPEs were used. The results showed that radiation cross-linking and vitamin E content both increased dielectric polarization in UHMWPE and under some conditions induced electrical conductivity. This result is significant because it shows that the conductive response of UHMWPE-bearing surfaces may depend on manufacturing processes and additives. (C) 2014 Wiley Periodicals, Inc. C1 [Antonio Puertolas, Jose; Jose Martinez-Morlanes, Maria; Javier Pascual, Francisco] Univ Zaragoza, Dept Mat Sci & Technol, Zaragoza, Spain. [Teruel, Roberto; Martinez-Felipe, Alfonso; Ribes, Amparo] Univ Politecn Valencia, Inst Mat Technol, E-46071 Valencia, Spain. [Oral, Ebru] Massachusetts Gen Hosp, Harris Orthopaed Lab, Boston, MA 02114 USA. [Javier Pascual, Francisco] Ctr Univ Def Zaragoza, Acad Gen Mil, Zaragoza, Spain. RP Puertolas, JA (reprint author), Univ Zaragoza, Dept Mat Sci & Technol, Zaragoza, Spain. EM japr@unizar.es RI Ribes-Greus, Amparo/K-1089-2014; Martinez-Felipe, Alfonso/L-6583-2014; OI Ribes-Greus, Amparo/0000-0003-2460-8291; Martinez-Felipe, Alfonso/0000-0002-1446-8398; Puertolas Rafales, Jose Antonio/0000-0002-3125-5802 FU Comision Interministerial de Ciencia y Tecnologia (CICYT), Spain; Ministerio de Ciencia e Innovacion [MAT 2010-16175]; [ENE2011-28735-C02-01]; [GRISOLIAP/2012/056] FX Research funded by the Comision Interministerial de Ciencia y Tecnologia (CICYT), Spain. Project MAT 2010-16175 from the Ministerio de Ciencia e Innovacion. The authors also acknowledge support from Project ENE2011-28735-C02-01 and Mr. Teruel Grant GRISOLIAP/2012/056. NR 32 TC 2 Z9 2 U1 1 U2 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD OCT 5 PY 2014 VL 131 IS 19 AR 40844 DI 10.1002/APP.40844 PG 8 WC Polymer Science SC Polymer Science GA AM9YV UT WOS:000340238300031 ER PT J AU Du, FX Zhang, MJ Li, XH Yang, CY Meng, H Wang, D Chang, S Xu, Y Price, B Sun, YL AF Du, Fengxia Zhang, Minjie Li, Xiaohua Yang, Caiyun Meng, Hao Wang, Dong Chang, Shuang Xu, Ye Price, Brendan Sun, Yingli TI Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE ATM activation; Intermolecular phosphorylation; Dephosphorylation; DNA repair ID DOUBLE-STRAND BREAKS; ATAXIA-TELANGIECTASIA; ACTIVATES ATM; DAMAGE; PROTEIN; KINASE; PHOSPHORYLATION; COMPLEX; GENE; AUTOPHOSPHORYLATION AB The ATM protein kinase, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks, mediates responses to ionizing radiation in mammalian cells. Here we show that ATM is held inactive in unirradiated cells as a dimer and phosphorylates the opposite strand of the dimer in response to DNA damage. Cellular irradiation induces rapid intermolecular autophosphorylation of serine 1981 that causes dimer dissociation and initiates cellular ATM kinase activity. ATM cannot phosphorylate the substrates when it could not undergo dimer monomer transition. After DNA repair, the active monomer will undergo dephosphorylation to form dimer again and dephosphorylation is critical for dimer reformation. Our work reveals novel function of ATM dimer monomer transition and explains why ATM dimer monomer transition plays such important role for ATM cellular activity during DNA repair. (C) 2014 Elsevier Inc. All rights reserved. C1 [Du, Fengxia; Zhang, Minjie; Li, Xiaohua; Yang, Caiyun; Meng, Hao; Wang, Dong; Chang, Shuang; Sun, Yingli] Chinese Acad Sci, Beijing Inst Genom, Lab Genome Variat & Precis Biomed, Beijing 100101, Peoples R China. [Zhang, Minjie; Meng, Hao; Wang, Dong; Chang, Shuang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China. [Price, Brendan] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol,Div Genom Stabil, Boston, MA 02134 USA. RP Price, B (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol,Div Genom Stabil, Boston, MA 02134 USA. EM Brendan_Price@dfci.harvard.edu; sunyl@big.ac.cn FU National Basic Research Program of China (973 Program) [2013CB911001, 2012CB518302]; National Natural Science Foundation of China [91019024, 31100558]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01040407] FX This work was supported by National Basic Research Program of China (973 Program, Grant Nos. 2013CB911001; 2012CB518302), National Natural Science Foundation of China (Grant Nos. 91019024; 31100558) and Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA01040407). NR 29 TC 1 Z9 1 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X EI 1090-2104 J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD OCT 3 PY 2014 VL 452 IS 4 BP 1034 EP 1039 DI 10.1016/j.bbrc.2014.09.038 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA AR1NC UT WOS:000343350900027 PM 25240135 ER PT J AU Rodius, S Nazarov, PV Nepomuceno-Chamorro, IA Jeanty, C Gonzalez-Rosa, JM Ibberson, M da Costa, RMB Xenarios, I Mercader, N Azuaje, F AF Rodius, Sophie Nazarov, Petr V. Nepomuceno-Chamorro, Isabel A. Jeanty, Celine Gonzalez-Rosa, Juan Manuel Ibberson, Mark da Costa, Ricardo M. Benites Xenarios, Ioannis Mercader, Nadia Azuaje, Francisco TI Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models SO BMC GENOMICS LA English DT Article DE Myocardial infarction; Zebrafish; Ventricular amputation; Ventricular cryoinjury; Heart regeneration; Transcriptional responses; Transcriptional association networks ID INDUCED MYOCARDIAL-INFARCTION; HEART REGENERATION; NEMALINE MYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; STEM-CELLS; CARDIOVASCULAR-SYSTEM; INTERACTION NETWORKS; EXPRESSION; PROLIFERATION; PERIOSTIN AB Background: Zebrafish is a clinically-relevant model of heart regeneration. Unlike mammals, it has a remarkable heart repair capacity after injury, and promises novel translational applications. Amputation and cryoinjury models are key research tools for understanding injury response and regeneration in vivo. An understanding of the transcriptional responses following injury is needed to identify key players of heart tissue repair, as well as potential targets for boosting this property in humans. Results: We investigated amputation and cryoinjury in vivo models of heart damage in the zebrafish through unbiased, integrative analyses of independent molecular datasets. To detect genes with potential biological roles, we derived computational prediction models with microarray data from heart amputation experiments. We focused on a top-ranked set of genes highly activated in the early post-injury stage, whose activity was further verified in independent microarray datasets. Next, we performed independent validations of expression responses with qPCR in a cryoinjury model. Across in vivo models, the top candidates showed highly concordant responses at 1 and 3 days post-injury, which highlights the predictive power of our analysis strategies and the possible biological relevance of these genes. Top candidates are significantly involved in cell fate specification and differentiation, and include heart failure markers such as periostin, as well as potential new targets for heart regeneration. For example, ptgis and ca2 were overexpressed, while usp2a, a regulator of the p53 pathway, was down-regulated in our in vivo models. Interestingly, a high activity of ptgis and ca2 has been previously observed in failing hearts from rats and humans. Conclusions: We identified genes with potential critical roles in the response to cardiac damage in the zebrafish. Their transcriptional activities are reproducible in different in vivo models of cardiac injury. C1 [Rodius, Sophie; Jeanty, Celine; Azuaje, Francisco] CRP Sante, NorLux Neurooncol Lab, Luxembourg, Luxembourg. [Nazarov, Petr V.] CRP Sante, Genom Res Unit, Luxembourg, Luxembourg. [Nepomuceno-Chamorro, Isabel A.] Univ Seville, Dept Lenguajes & Sistemas Informat, Seville, Spain. [Gonzalez-Rosa, Juan Manuel] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA. [Gonzalez-Rosa, Juan Manuel] Harvard Univ, Sch Med, Boston, MA USA. [Ibberson, Mark; Xenarios, Ioannis] SIB Swiss Inst Bioinformat, Vital IT Syst Biol Med Dept, Lausanne, Switzerland. [da Costa, Ricardo M. Benites; Xenarios, Ioannis] Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland. [Xenarios, Ioannis] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland. [Mercader, Nadia] CNIC, Dept Cardiovasc Dev & Repair, Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain. RP Azuaje, F (reprint author), CRP Sante, NorLux Neurooncol Lab, Luxembourg, Luxembourg. EM francisco.azuaje@crp-sante.lu FU INTER program of Luxembourg's National Research Fund (FNR); Swiss National Research Foundation (SNF); INFUSED project; Spanish Ministry of Economy and Competivity (TerCel projects) [BFU2011-25297]; Comunidad de Madrid [P2010/BMD-2321] FX This research was supported by the INTER program of Luxembourg's National Research Fund (FNR) and the Swiss National Research Foundation (SNF), INFUSED project (www.infused-project.eu). NM acknowledges support from Spanish Ministry of Economy and Competivity (BFU2011-25297 and TerCel projects) and the Comunidad de Madrid (P2010/BMD-2321). NR 77 TC 4 Z9 4 U1 2 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD OCT 3 PY 2014 VL 15 AR 852 DI 10.1186/1471-2164-15-852 PG 15 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AQ9MM UT WOS:000343178600001 PM 25280539 ER PT J AU Jayakar, SS Zhou, XJ Chiara, DC Dostalova, Z Savechenkov, PY Bruzik, KS Dailey, WP Miller, KW Eckenhoff, RG Cohen, JB AF Jayakar, Selwyn S. Zhou, Xiaojuan Chiara, David C. Dostalova, Zuzana Savechenkov, Pavel Y. Bruzik, Karol S. Dailey, William P. Miller, Keith W. Eckenhoff, Roderic G. Cohen, Jonathan B. TI Multiple Propofol-binding Sites in a gamma-Aminobutyric Acid Type A Receptor (GABA(A)R) Identified Using a Photoreactive Propofol Analog SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article DE Anesthesia; GABA Receptor; Nicotinic Acetylcholine Receptors (nAChR); Photoaffinity Labeling; Protein Drug Interaction; General Anesthetics; Propofol ID NICOTINIC ACETYLCHOLINE-RECEPTOR; GENERAL ANESTHETIC ETOMIDATE; GATED ION CHANNELS; AMINO-ACID; SUBUNIT INTERFACES; LOOP; CHOLESTEROL; BARBITURATE; SENSITIVITY; MODULATION AB Background: Propofol binding to GABA(A)R sites of uncertain location potentiates receptor function and produces anesthesia in vivo. Results: A photoreactive propofol analog identifies propofol-binding sites in 13 GABA(A)Rs. Conclusion: Propofol binds to each class of intersubunit sites in the GABA(A)R transmembrane domain. Significance: This study demonstrates that propofol binds to the same sites in a GABA(A)R as etomidate and barbiturates. Propofol acts as a positive allosteric modulator of -aminobutyric acid type A receptors (GABA(A)Rs), an interaction necessary for its anesthetic potency in vivo as a general anesthetic. Identifying the location of propofol-binding sites is necessary to understand its mechanism of GABA(A)R modulation. [H-3]2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate (azietomidate) and R-[H-3]5-allyl-1-methyl-5-(m-trifluoromethyl-diazirynylphenyl)barbituric acid (mTFD-MPAB), photoreactive analogs of 2-ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate (etomidate) and mephobarbital, respectively, have identified two homologous but pharmacologically distinct classes of intersubunit-binding sites for general anesthetics in the GABA(A)R transmembrane domain. Here, we use a photoreactive analog of propofol (2-isopropyl-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenol ([H-3]AziPm)) to identify propofol-binding sites in heterologously expressed human 13 GABA(A)Rs. Propofol, AziPm, etomidate, and R-mTFD-MPAB each inhibited [H-3]AziPm photoincorporation into GABA(A)R subunits maximally by approximate to 50%. When the amino acids photolabeled by [H-3]AziPm were identified by protein microsequencing, we found propofol-inhibitable photolabeling of amino acids in the 3-1 subunit interface (3Met-286 in 3M3 and 1Met-236 in 1M1), previously photolabeled by [H-3]azietomidate, and 1Ile-239, located one helical turn below 1Met-236. There was also propofol-inhibitable [H-3]AziPm photolabeling of 3Met-227 in M1, the amino acid in the 1-3 subunit interface photolabeled by R-[H-3]mTFD-MPAB. The propofol-inhibitable [H-3]AziPm photolabeling in the GABA(A)R 3 subunit in conjunction with the concentration dependence of inhibition of that photolabeling by etomidate or R-mTFD-MPAB also establish that each anesthetic binds to the homologous site at the 3-3 subunit interface. These results establish that AziPm as well as propofol bind to the homologous intersubunit sites in the GABA(A)R transmembrane domain that binds etomidate or R-mTFD-MPAB with high affinity. C1 [Jayakar, Selwyn S.; Chiara, David C.; Cohen, Jonathan B.] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA. [Miller, Keith W.] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA. [Zhou, Xiaojuan; Dostalova, Zuzana; Miller, Keith W.] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA. [Savechenkov, Pavel Y.; Bruzik, Karol S.] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA. [Dailey, William P.] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA. [Eckenhoff, Roderic G.] Univ Penn, Dept Anesthesiol & Crit Care, Perelman Sch Med, Philadelphia, PA 19104 USA. RP Cohen, JB (reprint author), Harvard Univ, Sch Med, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA. EM jonathan_cohen@hms.harvard.edu FU National Institutes of Health, USPHS [GM-58448, GM-55876] FX This work was supported, in whole or in part, by National Institutes of Health Grants GM-58448 (to J. B. C., K. S. B., and K. W. M.) and GM-55876 (to R. G. E.) from USPHS. NR 46 TC 24 Z9 24 U1 0 U2 25 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD OCT 3 PY 2014 VL 289 IS 40 BP 27456 EP 27468 DI 10.1074/jbc.M114.581728 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AQ5MH UT WOS:000342852800009 PM 25086038 ER PT J AU Stoeckel, LE Palley, LS Gollub, RL Niemi, SM Evins, AE AF Stoeckel, Luke E. Palley, Lori S. Gollub, Randy L. Niemi, Steven M. Evins, Anne Eden TI Patterns of Brain Activation when Mothers View Their Own Child and Dog: An fMRI Study SO PLOS ONE LA English DT Article ID OXYTOCIN-DOPAMINE INTERACTIONS; AINSWORTHS STRANGE SITUATION; FUSIFORM FACE AREA; ROMANTIC LOVE; ORBITOFRONTAL CORTEX; MATERNAL-BEHAVIOR; NEURAL ACTIVATION; CANIS-FAMILIARIS; PET OWNERSHIP; ATTACHMENT AB Neural substrates underlying the human-pet relationship are largely unknown. We examined fMRI brain activation patterns as mothers viewed images of their own child and dog and an unfamiliar child and dog. There was a common network of brain regions involved in emotion, reward, affiliation, visual processing and social cognition when mothers viewed images of both their child and dog. Viewing images of their child resulted in brain activity in the midbrain (ventral tegmental area/substantia nigra involved in reward/affiliation), while a more posterior cortical brain activation pattern involving fusiform gyrus (visual processing of faces and social cognition) characterized a mother's response to her dog. Mothers also rated images of their child and dog as eliciting similar levels of excitement (arousal) and pleasantness (valence), although the difference in the own vs. unfamiliar child comparison was larger than the own vs. unfamiliar dog comparison for arousal. Valence ratings of their dog were also positively correlated with ratings of the attachment to their dog. Although there are similarities in the perceived emotional experience and brain function associated with the mother-child and mother-dog bond, there are also key differences that may reflect variance in the evolutionary course and function of these relationships. C1 [Stoeckel, Luke E.; Gollub, Randy L.; Evins, Anne Eden] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Palley, Lori S.] Massachusetts Gen Hosp, Ctr Comparat Med, Boston, MA USA. [Stoeckel, Luke E.; Gollub, Randy L.; Evins, Anne Eden] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Niemi, Steven M.] Harvard Univ, Fac Arts & Sci, Cambridge, MA 02138 USA. RP Stoeckel, LE (reprint author), Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. EM lpalley@partners.org; lstoeckel@mgh.harvard.edu OI Gollub, Randy L./0000-0002-9434-4044 FU Massachusetts General Hospital Center for Comparative Medicine; Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital; Biomedical Technology Program of the National Institutes of Health National Center for Research Resources (NCRR); Harvard Catalyst \ The Harvard Clinical and Translational Science Center [NIH UL1 RR 025758]; Harvard University; Charles A. King Trust; NIH [K23DA032612, K24 DA030443] FX This research was funded by the Massachusetts General Hospital Center for Comparative Medicine, with additional support from the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using resources provided by the Center for Functional Neuroimaging Technologies, P41RR14075, a P41 Regional Resource supported by the Biomedical Technology Program of the National Institutes of Health National Center for Research Resources (NCRR). This work was also conducted with support from Harvard Catalyst vertical bar The Harvard Clinical and Translational Science Center (NIH UL1 RR 025758) and financial contributions from Harvard University and its affiliated academic health care centers. Finally, the study was supported by the Charles A. King Trust (LES), by NIH K23DA032612 (LES) and by NIH K24 DA030443 (AEE). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 66 TC 10 Z9 10 U1 9 U2 47 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 3 PY 2014 VL 9 IS 10 AR e107205 DI 10.1371/journal.pone.0107205 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ3DZ UT WOS:000342670800005 PM 25279788 ER PT J AU Theurillat, JPP Udeshi, ND Errington, WJ Svinkina, T Baca, SC Pop, M Wild, PJ Blattner, M Groner, AC Rubin, MA Moch, H Prive, GG Carr, SA Garraway, LA AF Theurillat, Jean-Philippe P. Udeshi, Namrata D. Errington, Wesley J. Svinkina, Tanya Baca, Sylvan C. Pop, Marius Wild, Peter J. Blattner, Mirjam Groner, Anna C. Rubin, Mark A. Moch, Holger Prive, Gilbert G. Carr, Steven A. Garraway, Levi A. TI Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer SO SCIENCE LA English DT Article ID DEK ONCOGENE; LIGASE; MUTATIONS; DEGRADATION; ADAPTER; TUMORIGENESIS; RECEPTOR; GENES; CELLS AB Cancer genome characterization has revealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these alterations promote tumorigenesis remain incompletely characterized. Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative fashion. Of these, DEK and TRIM24 emerged as effector substrates consistently up-regulated by SPOP mutants. We highlight DEK as a SPOP substrate that exhibited decreases in ubiquitylation and proteasomal degradation resulting from heteromeric complexes of wild-type and mutant SPOP protein. DEK stabilization promoted prostate epithelial cell invasion, which implicated DEK as an oncogenic effector. More generally, these results provide a framework to decipher tumorigenic mechanisms linked to dysregulated ubiquitylation. C1 [Theurillat, Jean-Philippe P.; Udeshi, Namrata D.; Svinkina, Tanya; Pop, Marius; Carr, Steven A.; Garraway, Levi A.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA. [Theurillat, Jean-Philippe P.; Baca, Sylvan C.; Pop, Marius; Garraway, Levi A.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Theurillat, Jean-Philippe P.; Baca, Sylvan C.; Pop, Marius; Groner, Anna C.; Garraway, Levi A.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Errington, Wesley J.; Prive, Gilbert G.] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada. [Errington, Wesley J.; Prive, Gilbert G.] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2M9, Canada. [Wild, Peter J.; Moch, Holger] Univ Zurich Hosp, Inst Surg Pathol, CH-8091 Zurich, Switzerland. [Blattner, Mirjam; Rubin, Mark A.] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA. [Rubin, Mark A.] Weill Cornell & New York Presbyterian Hosp, Inst Precis Med, New York, NY 10065 USA. [Garraway, Levi A.] Dana Farber Canc Inst, Ctr Canc Genome Discovery, Boston, MA 02115 USA. RP Garraway, LA (reprint author), Broad Inst Harvard & MIT, Cambridge, MA 02142 USA. EM levi_garraway@dfci.harvard.edu OI Rubin, Mark/0000-0002-8321-9950 FU Swiss Science foundation [SSMBS PASMP3_145764]; SystemX.ch grant (PhophoNet PPM), the Swiss initiative in systems biology; Novartis Foundation Medicine; Boehringer Ingelheim; Millennium/Takeda FX We thank L. Gaffney for illustrations and A. Fitsche and M. Storz for excellent technical assistance. J.-P.P.T. is funded by a fellowship from the Swiss Science foundation (SSMBS PASMP3_145764). P.J.W. is funded by a SystemX.ch grant (PhophoNet PPM), the Swiss initiative in systems biology. M. A. R. and Cornell University have filed a patent (WO 2012115789 A2) relating to the use of SPOP mutations as markers for human prostate cancer. L. A. G. is a paid consultant for the following pharmaceutical companies: Novartis Foundation Medicine, Boehringer Ingelheim, and Millennium/Takeda. NR 23 TC 43 Z9 43 U1 5 U2 30 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD OCT 3 PY 2014 VL 346 IS 6205 BP 85 EP 89 DI 10.1126/science.1250255 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ0BR UT WOS:000342446900056 PM 25278611 ER PT J AU Zwipp, J Hass, J Schober, I Geisler, D Ritschel, F Seidel, M Weiss, J Roessner, V Hellweg, R Ehrlich, S AF Zwipp, Johannes Hass, Johanna Schober, Ilka Geisler, Daniel Ritschel, Franziska Seidel, Maria Weiss, Jessika Roessner, Veit Hellweg, Rainer Ehrlich, Stefan TI Serum brain-derived neurotrophic factor and cognitive functioning in underweight, weight-recovered and partially weight-recovered females with anorexia nervosa SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY LA English DT Article DE Anorexia nervosa; BDNF; Cognitive functioning; Longitudinal; Weight gain ID EATING-DISORDERS; SCHIZOPHRENIC-PATIENTS; FACTOR EXPRESSION; BIPOLAR DISORDER; DECREASED LEVELS; BDNF VAL(66)MET; BULIMIA-NERVOSA; MICE; POLYMORPHISM; ASSOCIATION AB Several studies support the assumption that the brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of eating disorders. In the present cross-sectional and longitudinal study, we investigated BDNF levels in patients with anorexia nervosa (AN) at different stages of their illness and the association with cognitive functioning. We measured serum BDNF in 72 acutely underweight female AN patients (acAN), 23 female AN patients who successfully recovered from their illness (recAN), and 52 healthy control women (HCW). Longitudinally, 30 acAN patients were reassessed after short-term weight gain. The association between BDNF levels and psychomotor speed was investigated using the Trail Making Test. BDNF serum concentrations were significantly higher in recAN participants if compared to acAN patients and increased with short-term weight gain. In acAN patients, but not HCW, BDNF levels were inversely associated with psychomotor speed. AcAN patients with higher BDNF levels also had lower life time body mass indexes. Taken together, our results indicate that serum BDNF levels in patients with AN vary with the stage of illness. Based on the pleiotropic functions of BDNF, changing levels of this neurotrophin may have different context-dependent effects, one of which may be the modulation of cognitive functioning in acutely underweight patients. (C) 2014 Elsevier Inc. All rights reserved. C1 [Zwipp, Johannes; Hass, Johanna; Schober, Ilka; Geisler, Daniel; Ritschel, Franziska; Seidel, Maria; Weiss, Jessika; Roessner, Veit; Ehrlich, Stefan] Tech Univ Dresden, Fac Med, Dept Child & Adolescent Psychiat & Psychotherapy, D-01307 Dresden, Germany. [Hellweg, Rainer] Charite, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany. [Ehrlich, Stefan] Massachusetts Gen Hosp, MGH MIT HMS Martinos Ctr Biomed Imaging, Charlestown, MA USA. [Ehrlich, Stefan] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA. RP Ehrlich, S (reprint author), Tech Univ Dresden, Sch Med, Dept Child & Adolescent Psychiat, Translat Dev Neurosci Sect, Fetscherstr 74, D-01307 Dresden, Germany. EM transden.lab@gmail.com OI Ehrlich, Stefan/0000-0003-2132-4445 FU Deutsche Forschungsgemeinschaft [EH 367/5-1, SFB 940]; Swiss Anorexia Nervosa Foundation [19-12] FX This work was supported by the Deutsche Forschungsgemeinschaft (EH 367/5-1 & SFB 940) and the Swiss Anorexia Nervosa Foundation (19-12). NR 71 TC 7 Z9 7 U1 0 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-5846 EI 1878-4216 J9 PROG NEURO-PSYCHOPH JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry PD OCT 3 PY 2014 VL 54 BP 163 EP 169 DI 10.1016/j.pnpbp.2014.05.006 PG 7 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA AO2PN UT WOS:000341167800020 PM 24859292 ER PT J AU Ji, MH Jia, M Zhang, MQ Liu, WX Xie, ZC Wang, ZY Yang, JJ AF Ji, Mu-Huo Jia, Min Zhang, Ming-Qiang Liu, Wen-Xue Xie, Zhong-Cong Wang, Zhong-Yun Yang, Jian-Jun TI Dexmedetomidine alleviates anxiety-like behaviors and cognitive impairments in a rat model of post-traumatic stress disorder SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY LA English DT Article DE Anxiety-like behavior; Cognition; Dexmedetomidine; Post-traumatic stress disorder (PTSD) ID MEMORY; EXPRESSION; CLONIDINE; ISCHEMIA; INJURY; PTSD AB Post-traumatic stress disorder (PTSD) is a psychiatric disease that has substantial health implications, including high rates of health morbidity and mortality, as well as increased health-related costs. Although many pharmacological agents have proven the effects on the development of PTSD, current pharmacotherapies typically only produce partial improvement of PTSD symptoms. Dexmedetomidine is a selective, short-acting alpha(2)-adrenoceptor agonist, which has anxiolytic, sedative, and analgesic effects. We therefore hypothesized that dexmedetomidine possesses the ability to prevent the development of PTSD and alleviate its symptoms. By using the rat model of PTSD induced by five electric foot shocks followed by three weekly exposures to situational reminders, we showed that the stressed rats displayed pronounced anxiety-like behaviors and cognitive impairments compared to the controls. Notably, repeated administration of 20 mu g/kg dexmedetomidine showed impaired fear conditioning memory, decreased anxiety-like behaviors, and improved spatial cognitive impairments compared to the vehicle-treated stressed rats. These data suggest that dexmedetomidine may exert preventive and protective effects against anxiety-like behaviors and cognitive impairments in the rats with PTSD after repeated administration. (C) 2014 Elsevier Inc. All rights reserved. C1 [Ji, Mu-Huo; Jia, Min; Zhang, Ming-Qiang; Liu, Wen-Xue; Yang, Jian-Jun] Nanjing Univ, Jinling Hosp, Sch Med, Dept Anesthesiol, Nanjing 210008, Jiangsu, Peoples R China. [Xie, Zhong-Cong] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Geriatr Anesthesia Res Unit, Charlestown, MA USA. [Xie, Zhong-Cong] Harvard Univ, Sch Med, Dept Anesthesia Crit Care & Pain Med, Geriatr Anesthesia Res Unit, Charlestown, MA USA. [Wang, Zhong-Yun] Nanjing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Nanjing 210029, Jiangsu, Peoples R China. [Yang, Jian-Jun] Xuzhou Med Coll, Jiangsu Prov Key Lab Anesthesiol, Xuzhou, Peoples R China. [Yang, Jian-Jun] Jiangsu Prov Key Lab Anesthesia & Analgesia Appli, Xuzhou, Peoples R China. RP Wang, ZY (reprint author), Nanjing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China. EM zywang1970@126.com; yjyangjj@126.com FU National Natural Science Foundation of China [81271216, 81300946]; Natural Science Foundation of Jiangsu Province [BK2012778] FX This work was supported by the National Natural Science Foundation of China (Nos. 81271216 and 81300946) and the Natural Science Foundation of Jiangsu Province (No. BK2012778). NR 18 TC 7 Z9 10 U1 4 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-5846 J9 PROG NEURO-PSYCHOPH JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry PD OCT 3 PY 2014 VL 54 BP 284 EP 288 DI 10.1016/j.pnpbp.2014.06.013 PG 5 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA AO2PN UT WOS:000341167800035 PM 25004167 ER PT J AU Boehm, I Geisler, D King, JA Ritschel, F Seidel, M Araujo, YD Petermann, J Lohmeier, H Weiss, J Walter, M Roessner, V Ehrlich, S AF Boehm, Ilka Geisler, Daniel King, Joseph A. Ritschel, Franziska Seidel, Maria Araujo, Yacila Deza Petermann, Juliane Lohmeier, Heidi Weiss, Jessika Walter, Martin Roessner, Veit Ehrlich, Stefan TI Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE LA English DT Article DE anorexia nervosa; fMRI; resting state connectivity; fronto-parietal network; default mode network; insula; cognitive control; interoceptive awareness ID TRANSCRANIAL MAGNETIC STIMULATION; COGNITIVE CONTROL NETWORK; HEART-RATE-VARIABILITY; EATING-DISORDERS; BULIMIA-NERVOSA; NEUROCIRCUIT FUNCTION; RESPONSE-INHIBITION; ALZHEIMERS-DISEASE; EMOTION PERCEPTION; ANTERIOR INSULA AB The etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile of AN using cognitive and emotional task paradigms are difficult to reconcile. Task related imaging studies often require a high level of compliance and can only partially explore the distributed nature and complexity of brain function. In this study, resting state functional connectivity imaging was used to investigate well-characterized brain networks potentially relevant to understand the neural mechanisms underlying the symptomatology and etiology of AN Resting state functional magnetic resonance imaging data was obtained from 35 unmedicated female acute AN patients and 35 closely matched healthy controls female participants (HC) and decomposed using spatial group independent component analyses (ICA). Using validated templates, we identified components covering the fronto-parietal "control" network, the default mode network (DMN), the salience network, the visual and the sensory motor network. Group comparison revealed an increased functional connectivity between the angular gyrus and the other parts of the fronto-parietal network in patients with AN in comparison to HC. Connectivity of the angular gyrus was positively associated with self-reported persistence in HC. In the DMN, AN patients also showed an increased functional connectivity strength in the anterior insula in comparison to HC. Anterior insula connectivity was associated with self-reported problems with interoceptive awareness. This study, with one of the largest sample to date, shows that acute AN is associated with abnormal brain connectivity in two major resting state networks (RSN). The finding of an increased functional connectivity in the fronto-panetal network adds novel support for the notion of AN as a disorder of excessive cognitive control, whereas the elevated functional connectivity of the anterior insula with the DMN may reflect the high levels of self- and body-focused ruminations when AN patients are at rest. C1 [Boehm, Ilka; Geisler, Daniel; King, Joseph A.; Ritschel, Franziska; Seidel, Maria; Araujo, Yacila Deza; Petermann, Juliane; Weiss, Jessika; Roessner, Veit; Ehrlich, Stefan] Tech Univ Dresden, Dept Child & Adolescent Psychiat, Translat Dev Neurosci Sect,Fac Med, Eating Disorder Serv & Res Ctr,Univ Hosp CG Carus, D-01307 Dresden, Germany. [Lohmeier, Heidi] Tech Univ Dresden, Dept Psychotherapy & Psychosomat Med, Fac Med, Univ Hosp CG Carus, D-01307 Dresden, Germany. [Walter, Martin] Otto Von Guericke Univ, Dept Psychiat, Magdeburg, Germany. [Ehrlich, Stefan] Massachusetts Gen Hosp, MGH MIT HMS Martinos Ctr Biomed Imaging, Charlestown, MA USA. [Ehrlich, Stefan] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA USA. RP Ehrlich, S (reprint author), Tech Univ Dresden, Dept Child & Adolescent Psychiat, Translat Dev Neurosci Sect,Fac Med, Eating Disorder Serv & Res Ctr,Univ Hosp CG Carus, Fetscherstr 74, D-01307 Dresden, Germany. EM transden.lab@gmail.com OI Ehrlich, Stefan/0000-0003-2132-4445 FU Deutsche Forschungsgemeinschaft [EH 367/5-1, SFB 940]; Swiss Anorexia Nervosa Foundation; DAAD FX This work was supported by the Deutsche Forschungsgemeinschaft (EH 367/5-1 & SFB 940) the Swiss Anorexia Nervosa Foundation and the DAAD (scholarship to Yacila Deza Araujo). The authors would like to express their gratitude to Laura Soltwedel, Benjamin Roschinski, Juliane Petermann, Franziska Nelda, Luisa Flohr, Eva Seeger, Lea Scheuvens, Juliane Hantke and Constanze Nicklisch for their assistance with participant recruitment and data collection and thank all participants for their time and cooperation. NR 90 TC 13 Z9 13 U1 5 U2 29 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5153 J9 FRONT BEHAV NEUROSCI JI Front. Behav. Neurosci. PD OCT 2 PY 2014 VL 8 AR 346 DI 10.3389/fnbeh.2014.00346 PG 11 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA AW0LL UT WOS:000345983600001 PM 25324749 ER PT J AU Kaminer, Y Gordon, AJ AF Kaminer, Yifrah Gordon, Adam J. TI It Is Getting Late Here Early: Youth Substance Abuse Theory and Practice SO SUBSTANCE ABUSE LA English DT Editorial Material C1 [Kaminer, Yifrah] Univ Connecticut, Ctr Hlth, Dept Psychiat, Alcohol Res Ctr, Farmington, CT 06032 USA. [Kaminer, Yifrah] Univ Connecticut, Ctr Hlth, Dept Pediat, Alcohol Res Ctr, Farmington, CT USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, CHERP, Pittsburgh, PA 15240 USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, VISN Mental Illness Res Educ & Clin Ctr MIRECC 4, Pittsburgh, PA 15240 USA. [Gordon, Adam J.] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA USA. RP Gordon, AJ (reprint author), VA Pittsburgh Healthcare Syst, CHERP, Univ Dr C,Bldg 30, Pittsburgh, PA 15240 USA. EM adam.gordon@va.gov NR 12 TC 3 Z9 3 U1 0 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 EI 1547-0164 J9 SUBST ABUS JI Subst. Abus. PD OCT 2 PY 2014 VL 35 IS 4 SI SI BP 329 EP 330 DI 10.1080/08897077.2014.956023 PG 2 WC Substance Abuse SC Substance Abuse GA AW3MO UT WOS:000346191100001 PM 25148071 ER PT J AU Labbe, AK Slaymaker, V Kelly, JF AF Labbe, Allison K. Slaymaker, Valerie Kelly, John F. TI Toward Enhancing 12-Step Facilitation Among Young People: A Systematic Qualitative Investigation of Young Adults' 12-Step Experiences SO SUBSTANCE ABUSE LA English DT Article DE young adults; qualitative research; Alcoholics Anonymous; 12-step; self-help; 12-step facilitation; mutual-help organizations ID SELF-HELP GROUPS; SUBSTANCE-ABUSE; HEALTH-CARE; MUTUAL-HELP; GROUP INVOLVEMENT; REDUCE DEMAND; USE DISORDERS; ALCOHOL; PARTICIPATION; OUTCOMES AB ABSTRACT. Background: 12-Step Facilitation (TSF) interventions designed to enhance rates of engagement with 12-step mutual-help organizations (MHOs) have shown efficacy among adults, but research provides little guidance on how to adapt TSF strategies for young people. Methods: To inform TSF strategies for youth, this study used qualitative methods to investigate the self-reported experiences of 12-step participation, and reasons for nonattendance and discontinuation among young adults (18-24years; N = 302). Responses to open-ended questions following residential treatment were coded into rationally derived domains. Results: Young adults reported that cohesiveness, belonging, and instillation of hope were the most helpful aspects of attending 12-step groups; meeting structure and having to motivate oneself to attend meetings were the most common aspects young adults liked least; logistical barriers and low recovery motivation and interest were the most common reasons for discontinued attendance; and perceptions that one did not have a problem or needed treatment were cited most often as reasons for never attending. Conclusions: Findings may inform and enhance strategies intended to engage young people with community-based recovery-focused 12-step MHOs and ultimately improve recovery outcomes. C1 [Labbe, Allison K.; Kelly, John F.] Massachusetts Gen Hosp, Dept Psychiat, Ctr Addict Med, Boston, MA 02114 USA. [Labbe, Allison K.; Kelly, John F.] Harvard Univ, Sch Med, Boston, MA USA. [Slaymaker, Valerie] Hazelden Fdn, Butler Ctr Res, Ctr City, MN USA. RP Kelly, JF (reprint author), Massachusetts Gen Hosp, Dept Psychiat, Ctr Addict Med, 60 Staniford St,Suite 120, Boston, MA 02114 USA. EM jkelly11@mgh.harvard.edu FU National Institute of Alcohol Abuse and Alcoholism [R21AA018185-02] FX This research was supported by grant funding from the National Institute of Alcohol Abuse and Alcoholism (R21AA018185-02) and by anonymous donations to the Hazelden Foundation. Funding agencies were not involved in any aspect of research design, execution, or interpretation. All opinions and conclusions expressed herein are those of the authors and not the funding agencies. NR 43 TC 5 Z9 5 U1 0 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 EI 1547-0164 J9 SUBST ABUS JI Subst. Abus. PD OCT 2 PY 2014 VL 35 IS 4 SI SI BP 399 EP 407 DI 10.1080/08897077.2014.950001 PG 9 WC Substance Abuse SC Substance Abuse GA AW3MO UT WOS:000346191100011 PM 25102256 ER PT J AU Rossi, S Huang, S Furtak, SC Belliveau, JW Ahveninen, J AF Rossi, Stephanie Huang, Samantha Furtak, Sharon C. Belliveau, John W. Ahveninen, Jyrki TI Functional connectivity of dorsal and ventral frontoparietal seed regions during auditory orienting SO BRAIN RESEARCH LA English DT Article DE Auditory attention; fMRI; Psychophysiological interaction; Auditory cortex; Voluntary orienting; Involuntary attention ID POSTERIOR CINGULATE CORTEX; SCALE NEURAL-NETWORK; SPATIAL ATTENTION; PARIETAL CORTEX; COGNITIVE CONTROL; BRAIN; REPRESENTATIONS; VOLUNTARY; CONFLICT; ARCHITECTURE AB Our ability to refocus auditory attention is vital for even the most routine day-to-day activities. Shifts in auditory attention can be initiated "voluntarily," or triggered "involuntarily" by unexpected novel sound events. Here we employed psychophysiological interaction (PPI) analyses of auditory functional MRI data, to compare functional connectivity patterns of distinct frontoparietal cortex regions during cued voluntary vs. novelty-driven involuntary auditory attention shifting. Overall, our frontoparietal seed regions exhibited significant PPI increases with auditory cortex (AC) areas during both cued and novelty-driven orienting. However, significant positive PPI patterns associated with voluntary auditory attention (cue > novel task regressor), but mostly absent in analyses emphasizing involuntary orienting (novel > cue task regressor), were observed with seeds within the frontal eye fields (PEP), superior parietal lobule (SPL), and right supramarginal gyri (SMG). In contrast, significant positive PPIs associated selectively with involuntary orienting were observed between ACs and seeds within the bilateral anterior interior frontal gyri (IFG), left posterior IFG, SMG, and posterior cingulate cortices (PCC). We also found indices of lateralization of different attention networks: PPI increases selective to voluntary attention occurred primarily within right-hemispheric regions, whereas those related to involuntary orienting were more frequent with left-hemisphere seeds. In conclusion, despite certain similarities in PPI patterns across conditions, the more dorsal aspects of right frontoparietal cortex demonstrated wider connectivity during cued/voluntary attention shifting, whereas certain left ventral frontoparietal seeds were more widely connected during novelty-triggered/involuntary orienting. Our findings provide partial support for distinct attention networks for voluntary and involuntary auditory attention. (C) 2014 Elsevier B.V. All rights reserved. C1 [Rossi, Stephanie; Huang, Samantha; Furtak, Sharon C.; Belliveau, John W.; Ahveninen, Jyrki] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula AMartinos Ctr Biomed Imaging,Dept Radio, Charlestown, MA USA. [Furtak, Sharon C.] Calif State Univ Sacramento, Dept Psychol, Sacramento, CA 95819 USA. [Belliveau, John W.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Ahveninen, J (reprint author), MGW MIT HMS Martinos Ctr, Bldg 149 13th St, Charlestown, MA 02129 USA. EM jyrki@nmr.mgh.harvard.edu FU National Institutes of Health Awards [R01MH083744, R21DC014134, R21DC010060, R01HD040712, R01NS037462]; National Institute of Biomedical Imaging and Bioengineering (NIBIB) [P41]; National Center for Research Resources Shared Instrumentation Grants [S10RR014978, S10RR021110, S10RR019307, S10RR014798, S10RR023401] FX We thank An-Yi Hung, Chinmayi Tengshe, Mary O'Hara, and Lawrence White. This work was supported by National Institutes of Health Awards R01MH083744, R21DC014134, R21DC010060, R01HD040712, and R01NS037462. This research was carried out at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital using resources provided by the Center for Functional Neuroimaging Technologies, P41E8015896, and a P41 Biotechnology Resource Grant provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health. The research environment was additionally supported by National Center for Research Resources Shared Instrumentation Grants S10RR014978, S10RR021110, S10RR019307, S10RR014798, and S10RR023401. NR 50 TC 2 Z9 2 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 EI 1872-6240 J9 BRAIN RES JI Brain Res. PD OCT 2 PY 2014 VL 1583 BP 159 EP 168 DI 10.1016/j.brainres.2014.08.002 PG 10 WC Neurosciences SC Neurosciences & Neurology GA AR1PP UT WOS:000343357400014 PM 25128464 ER PT J AU Shen, L Inoue, A He, J Liu, YT Lu, FL Zhang, Y AF Shen, Li Inoue, Azusa He, Jin Liu, Yuting Lu, Falong Zhang, Yi TI Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes SO CELL STEM CELL LA English DT Article ID BASE EXCISION-REPAIR; PREIMPLANTATION DEVELOPMENT; ACTIVE-DEMETHYLATION; EARLY EMBRYOS; METHYLATION LANDSCAPE; GENE-EXPRESSION; MAMMALIAN DNA; 5-METHYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; 5-CARBOXYLCYTOSINE AB With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during preimplantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demethylation, but demethylation of the maternal genome occurs via replication. Here we present genome-scale DNA methylation maps for both the paternal and maternal genomes of Tet3-depleted and/or DNA replication-inhibited zygotes. In both genomes, we found that inhibition of DNA replication blocks DNA demethylation independently from Tet3 function and that Tet3 facilitates DNA demethylation largely by coupling with DNA replication. For both genomes, our data indicate that replication-dependent dilution is the major contributor to demethylation, but Tet3 plays an important role, particularly at certain loci. Our study thus defines the respective functions of Tet3 and DNA replication in paternal DNA demethylation and reveals an unexpected contribution of Tet3 to demethylation of the maternal genome. C1 [Shen, Li; Inoue, Azusa; He, Jin; Liu, Yuting; Lu, Falong; Zhang, Yi] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA. [Shen, Li; Inoue, Azusa; He, Jin; Liu, Yuting; Lu, Falong; Zhang, Yi] Harvard Univ, Sch Med, Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA. [Shen, Li; Inoue, Azusa; He, Jin; Liu, Yuting; Lu, Falong; Zhang, Yi] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [Zhang, Yi] Harvard Univ, Sch Med, Harvard Stem Cell Inst, Boston, MA 02115 USA. RP Zhang, Y (reprint author), Harvard Univ, Sch Med, Howard Hughes Med Inst, WAB 149G 200 Longwood Ave, Boston, MA 02115 USA. EM yzhang@genetics.med.harvard.edu FU NIH [U01DK089565] FX We thank Drs. Hao Wu and Luis M. Tuesta for critical reading of the manuscript, Dr. Guoliang Xu for the Tet3 antibody. This project is supported by NIH grant U01DK089565. Y.Z. is an investigator of the Howard Hughes Medical Institute. NR 38 TC 62 Z9 62 U1 6 U2 34 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1934-5909 EI 1875-9777 J9 CELL STEM CELL JI Cell Stem Cell PD OCT 2 PY 2014 VL 15 IS 4 BP 459 EP 470 DI 10.1016/j.stem.2014.09.002 PG 12 WC Cell & Tissue Engineering; Cell Biology SC Cell Biology GA AR0DE UT WOS:000343235800012 PM 25280220 ER PT J AU Theunissen, TW Powell, BE Wang, HY Mitalipova, M Faddah, DA Reddy, J Fan, ZP Maetzel, D Ganz, K Shi, LY Lungjangwa, T Imsoonthornruksa, S Stelzer, Y Rangarajan, S D'Alessio, A Zhang, JM Gao, Q Dawlaty, MM Young, RA Gray, NS Jaenisch, R AF Theunissen, Thorold W. Powell, Benjamin E. Wang, Haoyi Mitalipova, Maya Faddah, Dina A. Reddy, Jessica Fan, Zi Peng Maetzel, Dorothea Ganz, Kibibi Shi, Linyu Lungjangwa, Tenzin Imsoonthornruksa, Sumeth Stelzer, Yonatan Rangarajan, Sudharshan D'Alessio, Ana Zhang, Jianming Gao, Qing Dawlaty, Meelad M. Young, Richard A. Gray, Nathanael S. Jaenisch, Rudolf TI Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency SO CELL STEM CELL LA English DT Article ID EMBRYONIC STEM-CELLS; GROUND-STATE PLURIPOTENCY; SELF-RENEWAL; SOMATIC-CELLS; EPIBLAST; DERIVATION; INACTIVATION; INHIBITORS AB Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological characteristics, raising the question of whether an earlier, "naive" state of pluripotency may exist in humans. Here we took a systematic approach to identify small molecules that support self-renewal of naive human ESCs based on maintenance of endogenous OCT4 distal enhancer activity, a molecular signature of ground state pluripotency. Iterative chemical screening identified a combination of five kinase inhibitors that induces and maintains OCT4 distal enhancer activity when applied directly to conventional human ESCs. These inhibitors generate human pluripotent cells in which transcription factors associated with the ground state of pluripotency are highly upregulated and bivalent chromatin domains are depleted. Comparison with previously reported naive human ESCs indicates that our conditions capture a distinct pluripotent state in humans that closely resembles that of mouse ESCs. This study presents a framework for defining the culture requirements of naive human pluripotent cells. C1 [Theunissen, Thorold W.; Powell, Benjamin E.; Wang, Haoyi; Mitalipova, Maya; Faddah, Dina A.; Reddy, Jessica; Fan, Zi Peng; Maetzel, Dorothea; Ganz, Kibibi; Shi, Linyu; Lungjangwa, Tenzin; Imsoonthornruksa, Sumeth; Stelzer, Yonatan; Rangarajan, Sudharshan; D'Alessio, Ana; Gao, Qing; Dawlaty, Meelad M.; Young, Richard A.; Jaenisch, Rudolf] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Faddah, Dina A.; Reddy, Jessica; Young, Richard A.; Jaenisch, Rudolf] MIT, Dept Biol, Cambridge, MA 02142 USA. [Fan, Zi Peng] MIT, Computat & Syst Biol Program, Cambridge, MA 02139 USA. [Zhang, Jianming; Gray, Nathanael S.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. RP Jaenisch, R (reprint author), Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA. EM jaenisch@wi.mit.edu RI Young, Richard/F-6495-2012; OI Young, Richard/0000-0001-8855-8647; Theunissen, Thorold/0000-0001-6943-7858 FU Simons Foundation (SFLIFE) [286977]; NIH [RO1-CA084198]; Sir Henry Wellcome Postdoctoral Fellowship [098889/Z/12/Z]; Boehringer Ingelheim Fonds Ph.D. Fellowship; Jerome and Florence Brill Graduate Student Fellowship; National Science Foundation Graduate Research Fellowship; Human Frontier Science Program Postdoctoral Fellowship FX We thank Dongdong Fu for sectioning, Raaji Alagappan and Ping Xu for preparation of MEFs, Ruth Flannery for embryo processing, Patti Wisniewski and Colin Zollo for cell sorting, David Sabatini and Kathleen Ottina for use of the Zymark Liquid Handling system, the Whitehead Genome Technology Core for assistance with expression array and ChIP-Seq analysis, and Jacob Hanna (Weizmann Institute) for providing C1-AAVS1-GFP human ESCs. This study was supported by a grant from the Simons Foundation (SFLIFE #286977 to R.J) and was supported in part by NIH grant RO1-CA084198 to R.J. T.W.T. is supported by a Sir Henry Wellcome Postdoctoral Fellowship (098889/Z/12/Z). B.E.P. is supported by a Boehringer Ingelheim Fonds Ph.D. Fellowship and a Jerome and Florence Brill Graduate Student Fellowship. D.A.F. is supported by a National Science Foundation Graduate Research Fellowship and a Jerome and Florence Brill Graduate Student Fellowship. Y.S. is supported by a Human Frontier Science Program Postdoctoral Fellowship. R.J. is a cofounder of Fate Therapeutics and an adviser to Stemgent. NR 36 TC 162 Z9 166 U1 6 U2 40 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1934-5909 EI 1875-9777 J9 CELL STEM CELL JI Cell Stem Cell PD OCT 2 PY 2014 VL 15 IS 4 BP 471 EP 487 DI 10.1016/j.stem.2014.07.002 PG 17 WC Cell & Tissue Engineering; Cell Biology SC Cell Biology GA AR0DE UT WOS:000343235800013 PM 25090446 ER PT J AU Minikel, EV Zerr, I Collins, SJ Ponto, C Boyd, A Klug, G Karch, A Kenny, J Collinge, J Takada, LT Forner, S Fong, JC Mead, S Geschwind, MD AF Minikel, Eric Vallabh Zerr, Inga Collins, Steven J. Ponto, Claudia Boyd, Alison Klug, Genevieve Karch, Andre Kenny, Joanna Collinge, John Takada, Leonel T. Forner, Sven Fong, Jamie C. Mead, Simon Geschwind, Michael D. TI Ascertainment Bias Causes False Signal of Anticipation in Genetic Prion Disease SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article ID CREUTZFELDT-JAKOB-DISEASE; AT-ONSET ANTICIPATION; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; RAPIDLY PROGRESSIVE DEMENTIA; PROTEIN GENE; HUNTINGTONS-DISEASE; LIBYAN JEWS; PANIC DISORDER; MUTATION; AGE AB Anticipation is the phenomenon whereby age of onset in genetic disease decreases in successive generations. Three independent reports have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G>A mutation in PRNP encoding a p.Glu200Lys (E200K) substitution in the prion protein. If confirmed, this finding would carry clear implications for genetic counseling. We analyzed pedigrees with this mutation from four prion centers worldwide (n = 217 individuals with the mutation) to analyze age of onset and death in affected and censored individuals. We show through simulation that selective ascertainment of individuals whose onset falls within the historical window since the mutation's 1989 discovery is sufficient to create robust false signals both of anticipation and of heritability of age of onset. In our data set, the number of years of anticipation observed depends upon how strictly the data are limited by the ascertainment window. Among individuals whose disease was directly observed at a study center, a 28-year difference between parent and child age of onset is observed (p = 0.002), but including individuals ascertained retrospectively through family history reduces this figure to 7 years (p = 0.005). Applying survival analysis to the most thoroughly ascertained subset of data eliminates the signal of anticipation. Moreover, even non-CJD deaths exhibit 16 years anticipation (p = 0.002), indicating that ascertainment bias can entirely explain observed anticipation. We suggest that reports of anticipation in genetic prion disease are driven entirely by ascertainment bias. Guidelines for future studies claiming statistical evidence for anticipation are suggested. C1 [Minikel, Eric Vallabh] Prion Alliance, Cambridge, MA 02139 USA. [Minikel, Eric Vallabh] Broad Inst, Cambridge, MA 02142 USA. [Minikel, Eric Vallabh] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA. [Zerr, Inga; Ponto, Claudia; Karch, Andre] Univ Gottingen, Natl Reference Ctr TSE, D-37073 Gottingen, Germany. [Zerr, Inga] German Ctr Neurodegenerat Dis DZNE, D-37073 Gottingen, Germany. [Collins, Steven J.; Boyd, Alison; Klug, Genevieve] Univ Melbourne, Australian Natl Creutzfeldt Jakob Dis Registry, Parkville, Vic 3010, Australia. [Kenny, Joanna; Collinge, John; Mead, Simon] UCL, Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London WC1N 3BG, England. [Kenny, Joanna; Collinge, John; Mead, Simon] UCL Hosp NHS Trust, Natl Hosp Neurol & Neurosurg, NHS Natl Prion Clin, London WC1N 3BG, England. [Takada, Leonel T.; Forner, Sven; Fong, Jamie C.; Geschwind, Michael D.] Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94158 USA. RP Minikel, EV (reprint author), Prion Alliance, Cambridge, MA 02139 USA. EM eric.minikel@prionalliance.org RI Karch, Andre/D-6973-2017; OI Karch, Andre/0000-0003-3014-8543; Collins, Steven/0000-0002-5245-6611; Kenny, Joanna/0000-0002-2271-1941 FU Commonwealth Department of Health; Robert Koch Institute by Federal Ministry of Health [1369-341]; Medical Research Council UK; National Institute for Health Research's Biomedical Research Centre at UCLH; NIH through NIH/NIA [R01 AG-031189, K23 AG021989, P50AG023501]; NIH/NCRR [UL1 RR024131]; NIH/NIA [AG021601]; NIH/NINDS [N01-NS-0-2328]; Michael J. Homer Family Fund FX We would like to thank all affected individuals and their families for contributing to this research; physicians who referred or reported cases to surveillance and provided pertinent clinical, neuroradiological, and neuropathological data; the staff of the Goettingen research unit and the Center for Neuropathology and Prion Research at the Ludwig-Maximilian University Munich; the U.S. National Prion Disease Pathology and Surveillance Center for providing genotyping services; and Michael E. Talkowski, Benjamin M. Neale, Mark J. Daly, and Daniel G. MacArthur for their contributions to this study. The Australian National Creutzfeldt-Jakob Disease Registry is funded by the Commonwealth Department of Health. German CJD Surveillance is supported by grants from the Robert Koch Institute by funds of the Federal Ministry of Health (grant no 1369-341). MRC Prion Unit is funded by Medical Research Council UK; the UK clinical studies were supported in part by the National Institute for Health Research's Biomedical Research Centre at UCLH. This work from UCSF was supported by NIH through NIH/NIA R01 AG-031189, K23 AG021989, P50AG023501, NIH/NCRR Grant Number UL1 RR024131, NIH/NIA AG021601, NIH/NINDS Contract N01-NS-0-2328, and Michael J. Homer Family Fund. E.V.M. received no specific funding for this work and volunteers his time on behalf of Prion Alliance. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. M.D.G. has served as a consultant for Lundbeck, MedaCorp, The Council of Advisors, and Neurophage. NR 54 TC 4 Z9 4 U1 0 U2 23 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0002-9297 EI 1537-6605 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT 2 PY 2014 VL 95 IS 4 BP 371 EP 382 DI 10.1016/j.ajhg.2014.09.003 PG 12 WC Genetics & Heredity SC Genetics & Heredity GA AQ2XW UT WOS:000342654300003 PM 25279981 ER PT J AU Brand, H Pillalamarri, V Collins, RL Eggert, S O'Dushlaine, C Braaten, EB Stone, MR Chambert, K Doty, ND Hanscom, C Rosenfeld, JA Ditmars, H Blais, J Mills, R Lee, C Gusella, JF McCarroll, S Smoller, JW Talkowski, ME Doyle, AE AF Brand, Harrison Pillalamarri, Vamsee Collins, Ryan L. Eggert, Stacey O'Dushlaine, Colm Braaten, Ellen B. Stone, Matthew R. Chambert, Kimberly Doty, Nathan D. Hanscom, Carrie Rosenfeld, Jill A. Ditmars, Hillary Blais, Jessica Mills, Ryan Lee, Charles Gusella, James F. McCarroll, Steven Smoller, Jordan W. Talkowski, Michael E. Doyle, Alysa E. TI Cryptic and Complex Chromosomal Aberrations in Early-Onset Neuropsychiatric Disorders SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article ID COPY NUMBER VARIATION; AUTISM SPECTRUM DISORDERS; STRUCTURAL VARIATION; BIPOLAR-DISORDER; HUMAN GENOME; SCHIZOPHRENIA; VARIANTS; DELETION; RISK; REARRANGEMENTS AB Structural variation (SV) is a significant component of the genetic etiology of both neurodevelopmental and psychiatric disorders; however, routine guidelines for clinical genetic screening have been established only in the former category. Genome-wide chromosomal microarray (CMA) can detect genomic imbalances such as copy-number variants (CNVs), but balanced chromosomal abnormalities (BCAs) still require karyotyping for clinical detection. Moreover, submicroscopic BCAs and subarray threshold CNVs are intractable, or cryptic, to both CMA and karyotyping. Here, we performed whole-genome sequencing using large-insert jumping libraries to delineate both cytogenetically visible and cryptic SVs in a single test among 30 clinically referred youth representing a range of severe neuropsychiatric conditions. We detected 96 SVs per person on average that passed filtering criteria above our highest-confidence resolution (6,305 bp) and an additional 111 SVs per genome below this resolution. These SVs rearranged 3.8 Mb of genomic sequence and resulted in 42 putative loss-of-function (LoF) or gain-of-function mutations per person. We estimate that 80% of the LoF variants were cryptic to clinical CMA. We found myriad complex and cryptic rearrangements, including a "paired" duplication (360 kb, 169 kb) that flanks a 5.25 Mb inversion that appears in 7 additional cases from clinical CNV data among 47,562 individuals. Following convergent genomic profiling of these independent clinical CNV data, we interpreted three SVs to be of potential clinical significance. These data indicate that sequence-based delineation of the full SV mutational spectrum warrants exploration in youth referred for neuropsychiatric evaluation and clinical diagnostic SV screening more broadly. C1 [Brand, Harrison; Pillalamarri, Vamsee; Collins, Ryan L.; Eggert, Stacey; Stone, Matthew R.; Hanscom, Carrie; Ditmars, Hillary; Blais, Jessica; Gusella, James F.; Smoller, Jordan W.; Talkowski, Michael E.; Doyle, Alysa E.] Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA. [Brand, Harrison; Eggert, Stacey; Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Brand, Harrison; Eggert, Stacey; Braaten, Ellen B.; Doty, Nathan D.; Gusella, James F.; Smoller, Jordan W.; Talkowski, Michael E.; Doyle, Alysa E.] Harvard Univ, Sch Med, Boston, MA 02114 USA. [Eggert, Stacey; Gusella, James F.; McCarroll, Steven] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [O'Dushlaine, Colm; Chambert, Kimberly; Gusella, James F.; McCarroll, Steven; Smoller, Jordan W.; Talkowski, Michael E.; Doyle, Alysa E.] Broad Inst, Stanley Ctr Psychiat Res, Cambridge, MA 02141 USA. [O'Dushlaine, Colm; Chambert, Kimberly; Gusella, James F.; McCarroll, Steven; Smoller, Jordan W.; Talkowski, Michael E.; Doyle, Alysa E.] Broad Inst, Program Med & Populat Genet, Cambridge, MA 02141 USA. [Braaten, Ellen B.; Doty, Nathan D.; Smoller, Jordan W.; Talkowski, Michael E.; Doyle, Alysa E.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Rosenfeld, Jill A.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA. [Mills, Ryan] Univ Michigan, Med Ctr, Dept Computat Med, Ann Arbor, MI 48109 USA. [Mills, Ryan] Univ Michigan, Med Ctr, Dept Bioinformat & Human Genet, Ann Arbor, MI 48109 USA. [Lee, Charles] Jackson Lab Genom Med, Farmington, CT 06030 USA. RP Talkowski, ME (reprint author), Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA. EM talkowski@chgr.mgh.harvard.edu; doylea@helix.mgh.harvard.edu RI Mills, Ryan/A-1979-2011; OI Mills, Ryan/0000-0003-3425-6998; Collins, Ryan/0000-0003-1268-9995 FU National Institute of Mental Health [MH095867]; Simons Foundation for Autism Research; Nancy Lurie Marks Family Foundation; March of Dimes; Charles Hood Foundation; Brain and Behavioral Research Foundation (NARSAD); Stanley Center for Psychiatric Research; David Judah Foundation; NIMH [K24MH094614] FX The genomic studies were supported by funds from the National Institute of Mental Health (MH095867), the Simons Foundation for Autism Research, the Nancy Lurie Marks Family Foundation, the March of Dimes, the Charles Hood Foundation, and the Brain and Behavioral Research Foundation (NARSAD) to M.E.T. The LOGIC study and affiliated personnel were supported by funds from the Stanley Center for Psychiatric Research and the David Judah Foundation to A.E.D. J.W.M. is supported in part by NIMH grant K24MH094614. NR 49 TC 17 Z9 17 U1 0 U2 2 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0002-9297 EI 1537-6605 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT 2 PY 2014 VL 95 IS 4 BP 454 EP 461 DI 10.1016/j.ajhg.2014.09.005 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA AQ2XW UT WOS:000342654300010 PM 25279985 ER PT J AU Abdel-Mohsen, M Deng, XT Danesh, A Liegler, T Jacobs, ES Rauch, A Ledergerber, B Norris, PJ Gunthard, HF Wong, JK Pillai, SK AF Abdel-Mohsen, Mohamed Deng, Xutao Danesh, Ali Liegler, Teri Jacobs, Evan S. Rauch, Andri Ledergerber, Bruno Norris, Philip J. Guenthard, Huldrych F. Wong, Joseph K. Pillai, Satish K. TI Role of MicroRNA Modulation in the Interferon-alpha/Ribavirin Suppression of HIV-1 In Vivo SO PLOS ONE LA English DT Article ID PERSISTENT LCMV INFECTION; C VIRUS; ANTIRETROVIRAL ACTIVITY; PEGINTERFERON ALPHA-2A; RESTRICTION FACTORS; CELLULAR MICRORNAS; ELITE SUPPRESSORS; GENE-EXPRESSION; CELLS; APOPTOSIS AB Background: Interferon-alpha (IFN-alpha) treatment suppresses HIV-1 viremia and reduces the size of the HIV-1 latent reservoir. Therefore, investigation of the molecular and immunologic effects of IFN-alpha may provide insights that contribute to the development of novel prophylactic, therapeutic and curative strategies for HIV-1 infection. In this study, we hypothesized that microRNAs (miRNAs) contribute to the IFN-alpha-mediated suppression of HIV-1. To inform the development of novel miRNA-based antiretroviral strategies, we investigated the effects of exogenous IFN-alpha treatment on global miRNA expression profile, HIV-1 viremia, and potential regulatory networks between miRNAs and cell-intrinsic anti-HIV-1 host factors in vivo. Methods: Global miRNA expression was examined in longitudinal PBMC samples obtained from seven HIV/HCV-coinfected, antiretroviral therapy-naive individuals before, during, and after pegylated interferon-alpha/ribavirin therapy (IFN-alpha/RBV). We implemented novel hybrid computational-empirical approaches to characterize regulatory networks between miRNAs and anti-HIV-1 host restriction factors. Results: miR-422a was the only miRNA significantly modulated by IFN-alpha/RBV in vivo (p < 0.0001, paired t test; FDR < 0.037). Our interactome mapping revealed extensive regulatory involvement of miR-422a in p53-dependent apoptotic and pyroptotic pathways. Based on sequence homology and inverse expression relationships, 29 unique miRNAs may regulate anti-HIV-1 restriction factor expression in vivo. Conclusions: The specific reduction of miR-422a is associated with exogenous IFN-alpha treatment, and likely contributes to the IFN-alpha suppression of HIV-1 through the enhancement of anti-HIV-1 restriction factor expression and regulation of genes involved in programmed cell death. Moreover, our regulatory network analysis presents additional candidate miRNAs that may be targeted to enhance anti-HIV-1 restriction factor expression in vivo. C1 [Abdel-Mohsen, Mohamed; Liegler, Teri; Norris, Philip J.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Abdel-Mohsen, Mohamed; Deng, Xutao; Danesh, Ali; Jacobs, Evan S.; Norris, Philip J.; Pillai, Satish K.] Blood Syst Res Inst, San Francisco, CA 94118 USA. [Rauch, Andri] Univ Hosp Bern, Dept Infect Dis, CH-3010 Bern, Switzerland. [Rauch, Andri] Univ Bern, Bern, Switzerland. [Ledergerber, Bruno; Guenthard, Huldrych F.] Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland. [Norris, Philip J.; Pillai, Satish K.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Wong, Joseph K.] San Francisco VA Med Ctr, Dept Med, San Francisco, CA USA. RP Pillai, SK (reprint author), Blood Syst Res Inst, San Francisco, CA 94118 USA. EM satish.pillai@ucsf.edu RI SHCS, int. coll. A/G-4083-2011; Infektiologie, USZ/A-6921-2011; SHCS, all/G-4072-2011; Ledergerber, Bruno/B-5656-2009; gunthard, huldrych/F-1724-2011 OI Ledergerber, Bruno/0000-0002-6881-4401; gunthard, huldrych/0000-0002-1142-6723 FU National Institutes of Health [1K01DA024654]; University of California, San Francisco-Gladstone Institute of Virology & Immunology Center for AIDS Research [P30 AI027763]; Swiss HIV Cohort Study Project [594]; Swiss National Science Foundation [324730-130865, 33CS30-134277]; Swiss HIV Cohort Study Research Foundation FX This study was supported by grants from the National Institutes of Health 1K01DA024654, and the University of California, San Francisco-Gladstone Institute of Virology & Immunology Center for AIDS Research (grant number P30 AI027763). Additional support was provided by Swiss HIV Cohort Study Project 594 and Swiss National Science Foundation Grant 324730-130865. The Swiss HIV Cohort Study is supported by Swiss National Science Foundation Grant 33CS30-134277 and the Swiss HIV Cohort Study Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 3 Z9 3 U1 0 U2 33 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 2 PY 2014 VL 9 IS 10 AR e109220 DI 10.1371/journal.pone.0109220 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AQ2BX UT WOS:000342591500077 PM 25275557 ER PT J AU Marusyk, A Tabassum, DP Altrock, PM Almendro, V Michor, F Polyak, K AF Marusyk, Andriy Tabassum, Doris P. Altrock, Philipp M. Almendro, Vanessa Michor, Franziska Polyak, Kornelia TI Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity SO NATURE LA English DT Article ID IL-6 FAMILY CYTOKINE; CANCER; EVOLUTION; MODEL; TUMORIGENESIS; INFLAMMATION; COMPETITION; MUTATIONS; SELECTION; LEUKEMIA AB Cancers arise through a process of somatic evolution that can result in substantial sub-clonal heterogeneity within tumours. The mechanisms responsible for the coexistence of distinct sub-clones and the biological consequences of this coexistence remain poorly understood. Here we used a mouse xenograft model to investigate the impact of sub-clonal heterogeneity on tumour phenotypes and the competitive expansion of individual clones. We found that tumour growth can be driven by a minor cell subpopulation, which enhances the proliferation of all cells within a tumour by overcoming environmental constraints and yet can be outcompeted by faster proliferating competitors, resulting in tumour collapse. We developed a mathematical modelling framework to identify the rules underlying the generation of intra-tumour clonal heterogeneity. We found that non-cell-autonomous driving of tumour growth, together with clonal interference, stabilizes sub-clonal heterogeneity, thereby enabling inter-clonal interactions that can lead to new phenotypic traits. C1 [Marusyk, Andriy; Tabassum, Doris P.; Almendro, Vanessa; Polyak, Kornelia] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. [Marusyk, Andriy; Almendro, Vanessa; Polyak, Kornelia] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Marusyk, Andriy; Almendro, Vanessa; Polyak, Kornelia] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. [Tabassum, Doris P.; Polyak, Kornelia] Harvard Univ, Sch Med, BBS Program, Boston, MA 02115 USA. [Altrock, Philipp M.; Michor, Franziska] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02215 USA. [Altrock, Philipp M.; Michor, Franziska] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Altrock, Philipp M.] Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA. [Polyak, Kornelia] Harvard Stem Cell Inst, Cambridge, MA 02138 USA. [Polyak, Kornelia] Broad Inst, Cambridge, MA 02138 USA. RP Polyak, K (reprint author), Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. EM kornelia_polyak@dfci.harvard.edu FU Dana-Farber Cancer Institute Physical Sciences-Oncology Center [U54CA143798]; CDRMP Breast Cancer Research Program [W81XWH-09-1-0561]; Cellex Foundation; Deutsche Akademie der Naturforscher Leopoldina [LPDS2012-12]; Breast Cancer Research Foundation FX We thank J. DeGregori, A. Goldman, A. Rozhok, M. Gonen and members of the Polyak and Michor laboratories for their critical reading of this manuscript and discussions. We thank L. Cameron in the DFCI Confocal Microscopy for her technical support. This work was supported by the Dana-Farber Cancer Institute Physical Sciences-Oncology Center (U54CA143798 to F. M.), CDRMP Breast Cancer Research Program W81XWH-09-1-0561 (A. M.), Cellex Foundation (V. A.), Deutsche Akademie der Naturforscher Leopoldina LPDS2012-12 (P. M. A.) and the Breast Cancer Research Foundation (K.P.). NR 29 TC 126 Z9 131 U1 4 U2 47 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD OCT 2 PY 2014 VL 514 IS 7520 BP 54 EP + DI 10.1038/nature13556 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AP9SS UT WOS:000342420800033 PM 25079331 ER PT J AU Perry, JRB Day, F Elks, CE Sulem, P Thompson, DJ Ferreira, T He, CY Chasman, DI Esko, T Thorleifsson, G Albrecht, E Ang, WQ Corre, T Cousminer, DL Feenstra, B Franceschini, N Ganna, A Johnson, AD Kjellqvist, S Lunetta, KL McMahon, G Nolte, IM Paternoster, L Porcu, E Smith, AV Stolk, L Teumer, A Tsernikova, N Tikkanen, E Ulivi, S Wagner, EK Amin, N Bierut, LJ Byrne, EM Hottenga, JJ Koller, DL Mangino, M Pers, TH Yerges-Armstrong, LM Zhao, JH Andrulis, IL Anton-Culver, H Atsma, F Bandinelli, S Beckmann, MW Benitez, J Blomqvist, C Bojesen, SE Bolla, MK Bonanni, B Brauch, H Brenner, H Buring, JE Chang-Claude, J Chanock, S Chen, JH Chenevix-Trench, G Collee, JM Couch, FJ Couper, D Coviello, AD Cox, A Czene, K D'adamo, AP Smith, GD De Vivo, I Demerath, EW Dennis, J Devilee, P Dieffenbach, AK Dunning, AM Eiriksdottir, G Eriksson, JG Fasching, PA Ferrucci, L Flesch-Janys, D Flyger, H Foroud, T Franke, L Garcia, ME Garcia-Closas, M Geller, F de Geus, EEJ Giles, GG Gudbjartsson, DF Gudnason, V Guenel, P Guo, SQ Hall, P Hamann, U Haring, R Hartman, CA Heath, A Hofman, A Hooning, MJ Hopper, JL Hu, FB Hunter, DJ Karasik, D Kiel, DP Knight, JA Kosma, VM Kutalik, Z Lai, S Lambrechts, D Lindblom, A Magi, R Magnusson, PK Mannermaa, A Martin, NG Masson, G McArdle, PF McArdle, WL Melbye, M Michailidou, K Mihailov, E Milani, L Milne, RL Nevanlinna, H Neven, P Nohr, EA Oldehinkel, AJ Oostra, BA Palotie, A Peacock, M Pedersen, NL Peterlongo, P Peto, J Pharoah, PDP Postma, DS Pouta, A Pylkas, K Radice, P Ring, S Rivadeneira, F Robino, A Rose, LM Rudolph, A Salomaa, V Sanna, S Schlessinger, D Schmidt, MK Southey, MC Sovio, U Stampfer, MJ Stockl, D Storniolo, AM Timpson, NJ Tyrer, J Visser, JA Vollenweider, P Volzke, H Waeber, G Waldenberger, M Wallaschofski, H Wang, Q Willemsen, G Winqvist, R Wolffenbuttel, BHR Wright, MJ Boomsma, DI Econs, MJ Khaw, KT Loos, RJF McCarthy, MI Montgomery, GW Rice, JP Streeten, EA Thorsteinsdottir, U van Duijn, CM Alizadeh, BZ Bergmann, S Boerwinkle, E Boyd, HA Crisponi, L Gasparini, P Gieger, C Harris, TB Ingelsson, E Jarvelin, MR Kraft, P Lawlor, D Metspalu, A Pennell, CE Ridker, PM Snieder, H Sorensen, TIA Spector, TD Strachan, DP Uitterlinden, AG Wareham, NJ Widen, E Zygmunt, M Murray, A Easton, DF Stefansson, K Murabito, JM Ong, KK AF Perry, John R. B. Day, Felix Elks, Cathy E. Sulem, Patrick Thompson, Deborah J. Ferreira, Teresa He, Chunyan Chasman, Daniel I. Esko, Toenu Thorleifsson, Gudmar Albrecht, Eva Ang, Wei Q. Corre, Tanguy Cousminer, Diana L. Feenstra, Bjarke Franceschini, Nora Ganna, Andrea Johnson, Andrew D. Kjellqvist, Sanela Lunetta, Kathryn L. McMahon, George Nolte, Ilja M. Paternoster, Lavinia Porcu, Eleonora Smith, Albert V. Stolk, Lisette Teumer, Alexander Tsernikova, Natalia Tikkanen, Emmi Ulivi, Sheila Wagner, Erin K. Amin, Najaf Bierut, Laura J. Byrne, Enda M. Hottenga, Jouke-Jan Koller, Daniel L. Mangino, Massimo Pers, Tune H. Yerges-Armstrong, Laura M. Zhao, Jing Hua Andrulis, Irene L. Anton-Culver, Hoda Atsma, Femke Bandinelli, Stefania Beckmann, Matthias W. Benitez, Javier Blomqvist, Carl Bojesen, Stig E. Bolla, Manjeet K. Bonanni, Bernardo Brauch, Hiltrud Brenner, Hermann Buring, Julie E. Chang-Claude, Jenny Chanock, Stephen Chen, Jinhui Chenevix-Trench, Georgia Collee, J. Margriet Couch, Fergus J. Couper, David Coviello, Andrea D. Cox, Angela Czene, Kamila D'adamo, Adamo Pio Smith, George Davey De Vivo, Immaculata Demerath, Ellen W. Dennis, Joe Devilee, Peter Dieffenbach, Aida K. Dunning, Alison M. Eiriksdottir, Gudny Eriksson, Johan G. Fasching, Peter A. Ferrucci, Luigi Flesch-Janys, Dieter Flyger, Henrik Foroud, Tatiana Franke, Lude Garcia, Melissa E. Garcia-Closas, Montserrat Geller, Frank de Geus, Eco E. J. Giles, Graham G. Gudbjartsson, Daniel F. Gudnason, Vilmundur Guenel, Pascal Guo, Suiqun Hall, Per Hamann, Ute Haring, Robin Hartman, Catharina A. Heath, AndrewC. Hofman, Albert Hooning, Maartje J. Hopper, John L. Hu, Frank B. Hunter, David J. Karasik, David Kiel, Douglas P. Knight, Julia A. Kosma, Veli-Matti Kutalik, Zoltan Lai, Sandra Lambrechts, Diether Lindblom, Annika Maegi, Reedik Magnusson, Patrik K. Mannermaa, Arto Martin, Nicholas G. Masson, Gisli McArdle, Patrick F. McArdle, Wendy L. Melbye, Mads Michailidou, Kyriaki Mihailov, Evelin Milani, Lili Milne, Roger L. Nevanlinna, Heli Neven, Patrick Nohr, Ellen A. Oldehinkel, Albertine J. Oostra, Ben A. Palotie, Aarno Peacock, Munro Pedersen, Nancy L. Peterlongo, Paolo Peto, Julian Pharoah, Paul D. P. Postma, Dirkje S. Pouta, Anneli Pylkaes, Katri Radice, Paolo Ring, Susan Rivadeneira, Fernando Robino, Antonietta Rose, Lynda M. Rudolph, Anja Salomaa, Veikko Sanna, Serena Schlessinger, David Schmidt, Marjanka K. Southey, Mellissa C. Sovio, Ulla Stampfer, Meir J. Stoeckl, Doris Storniolo, Anna M. Timpson, Nicholas J. Tyrer, Jonathan Visser, Jenny A. Vollenweider, Peter Voelzke, Henry Waeber, Gerard Waldenberger, Melanie Wallaschofski, Henri Wang, Qin Willemsen, Gonneke Winqvist, Robert Wolffenbuttel, Bruce H. R. Wright, Margaret J. Boomsma, Dorret I. Econs, Michael J. Khaw, Kay-Tee Loos, Ruth J. F. McCarthy, Mark I. Montgomery, Grant W. Rice, John P. Streeten, Elizabeth A. Thorsteinsdottir, Unnur van Duijn, Cornelia M. Alizadeh, Behrooz Z. Bergmann, Sven Boerwinkle, Eric Boyd, Heather A. Crisponi, Laura Gasparini, Paolo Gieger, Christian Harris, Tamara B. Ingelsson, Erik Jaervelin, Marjo-Riitta Kraft, Peter Lawlor, Debbie Metspalu, Andres Pennell, Craig E. Ridker, Paul M. Snieder, Harold Sorensen, Thorkild I. A. Spector, Tim D. Strachan, David P. Uitterlinden, Andre G. Wareham, Nicholas J. Widen, Elisabeth Zygmunt, Marek Murray, Anna Easton, Douglas F. Stefansson, Kari Murabito, Joanne M. Ong, Ken K. CA Australian Ovarian Canc Study GENICA Network kConFabt LifeLines Cohort Study InterAct Consortium Early Growth Genetics EGG Consorti TI Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche SO NATURE LA English DT Article ID CENTRAL PRECOCIOUS PUBERTY; HUMAN PREFRONTAL CORTEX; BREAST-CANCER RISK; GENE-EXPRESSION; WIDE ASSOCIATION; METAANALYSIS; DISEASE; VARIANTS; CELLS; REVEALS AB Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-causemortality(1). Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation(2,3), but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 x 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and gamma-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition. C1 [Perry, John R. B.; Day, Felix; Elks, Cathy E.; Zhao, Jing Hua; Loos, Ruth J. F.; Wareham, Nicholas J.; Ong, Ken K.] Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Inst Metab Sci, Cambridge CB2 0QQ, England. [Perry, John R. B.; Murray, Anna] Univ Exeter, Sch Med, Exeter EX1 2LU, Devon, England. [Perry, John R. B.; Ferreira, Teresa; McCarthy, Mark I.] Univ Oxford, Wellcome Trust Ctr forHuman Genet, Oxford OX3 7BN, England. [Perry, John R. B.; Mangino, Massimo; Spector, Tim D.] Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England. [Sulem, Patrick; Thorleifsson, Gudmar; Masson, Gisli; Thorsteinsdottir, Unnur; Stefansson, Kari] DeCODE Genet, IS-101 Reykjavik, Iceland. [Thompson, Deborah J.; Bolla, Manjeet K.; Dennis, Joe; Gudbjartsson, Daniel F.; Michailidou, Kyriaki; Wang, Qin; Easton, Douglas F.] Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England. [He, Chunyan; Wagner, Erin K.] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46202 USA. [He, Chunyan; Wagner, Erin K.] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA. [Chasman, Daniel I.; Buring, Julie E.; Rose, Lynda M.; Ridker, Paul M.] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA. [Chasman, Daniel I.; Buring, Julie E.; Karasik, David; Ridker, Paul M.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Esko, Toenu; Tsernikova, Natalia; Maegi, Reedik; Mihailov, Evelin; Milani, Lili; Metspalu, Andres] Univ Tartu, Estonian Genome Ctr, Tartu 51010, Estonia. [Esko, Toenu; Pers, Tune H.] Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA. [Esko, Toenu; Pers, Tune H.] Boston Childrens Hosp, Div Genet, Boston, MA 02115 USA. [Esko, Toenu; Pers, Tune H.] Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA. [Esko, Toenu; Pers, Tune H.; Hunter, David J.] MIT, Board Inst, Cambridge, MA 02142 USA. [Esko, Toenu; Pers, Tune H.; Hunter, David J.] Harvard Univ, Cambridge, MA 02142 USA. [Esko, Toenu] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [Albrecht, Eva; Gieger, Christian] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany. [Ang, Wei Q.; Pennell, Craig E.] Univ Western Australia, Sch Womens & Infants Hlth, Nedlands, WA 6009, Australia. [Corre, Tanguy; Kutalik, Zoltan; Bergmann, Sven] Univ Lausanne, Dept Med Genet, CH-1005 Lausanne, Switzerland. [Corre, Tanguy; Kutalik, Zoltan; Bergmann, Sven] Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland. [Cousminer, Diana L.; Tikkanen, Emmi; Palotie, Aarno; Widen, Elisabeth] Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland. [Feenstra, Bjarke; Geller, Frank; Melbye, Mads; Boyd, Heather A.] Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark. [Franceschini, Nora] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA. [Ganna, Andrea; Czene, Kamila; Hall, Per; Magnusson, Patrik K.; Pedersen, Nancy L.] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden. [Johnson, Andrew D.; Lunetta, Kathryn L.; Murabito, Joanne M.] NHLBI, Framingham, MA 01702 USA. [Johnson, Andrew D.; Lunetta, Kathryn L.; Murabito, Joanne M.] Boston Univ Framingham Heart Study, Framingham, MA 01702 USA. [Kjellqvist, Sanela] Karolinska Inst, Sci Life Lab, S-17121 Solna, Sweden. [Lunetta, Kathryn L.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA. [McMahon, George; Paternoster, Lavinia; Smith, George Davey; Ring, Susan; Timpson, Nicholas J.; Lawlor, Debbie] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England. [McMahon, George; Smith, George Davey; McArdle, Wendy L.; Ring, Susan; Timpson, Nicholas J.; Lawlor, Debbie] Univ Bristol, Sch Social & Community Med, Bristol BS8 2BN, Avon, England. [Nolte, Ilja M.; Alizadeh, Behrooz Z.; Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands. [Porcu, Eleonora; Lai, Sandra; Sanna, Serena; Crisponi, Laura] CNR, Inst Genet & Biomed Res, I-09042 Cagliari, Sardinia, Italy. [Porcu, Eleonora] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy. [Smith, Albert V.; Eiriksdottir, Gudny; Gudnason, Vilmundur] Iceland Heart Assoc, IS-201 Kopavogur, Iceland. [Smith, Albert V.; Gudnason, Vilmundur] Univ Iceland, IS-101 Reykjavik, Iceland. [Stolk, Lisette; Rivadeneira, Fernando; Visser, Jenny A.; Uitterlinden, Andre G.] Erasmus MC, Dept Internal Med, NL-3015 GE Rotterdam, Netherlands. [Stolk, Lisette; Rivadeneira, Fernando; van Duijn, Cornelia M.; Uitterlinden, Andre G.] Netherlands Consortium Hlth Aging, NL-2300 RC Leiden, Netherlands. [Stolk, Lisette; Rivadeneira, Fernando; van Duijn, Cornelia M.; Uitterlinden, Andre G.] Natl Genom Initiat, NL-2300 RC Leiden, Netherlands. [Teumer, Alexander] Univ Med Greifswald, Interfac Inst Genet & Funct Gen, D-17475 Greifswald, Germany. [Tsernikova, Natalia; Mihailov, Evelin; Metspalu, Andres] Univ Tartu, Dept Biotechnol, EE-51010 Tartu, Estonia. [Tikkanen, Emmi] Univ Helsinki, Hjelt Inst, FI-00014 Helsinki, Finland. [Ulivi, Sheila; D'adamo, Adamo Pio; Robino, Antonietta; Gasparini, Paolo] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, I-34137 Trieste, Italy. 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[Voelzke, Henry] Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany. [Voelzke, Henry; Wallaschofski, Henri] DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany. [Waldenberger, Melanie] Helmholtz Zentrum Munchen German Res Ctr Environm, Res Unit Mol Epidemiol, D-8576 Neuherberg, Germany. [Wolffenbuttel, Bruce H. R.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 AB Groningen, Netherlands. [Wright, Margaret J.; Montgomery, Grant W.] Queensland Inst Med Res, Brisbane, Qld 4029, Australia. [Khaw, Kay-Tee] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 0QQ, England. [Loos, Ruth J. F.] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, Mindich Child Hlth & Dev Inst, Dept Prevent Med,Genet Obes & Related Metab Trait, New York, NY 10029 USA. [McCarthy, Mark I.] Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford OX3 7LE, England. [McCarthy, Mark I.] Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England. [Streeten, Elizabeth A.] Geriatr Res & Educ Clin Ctr GRECC, Vet Adm Med Ctr, Baltimore, MD 21201 USA. [van Duijn, Cornelia M.] Ctr Med Syst Biol, NL-2300 RC Leiden, Netherlands. [Boerwinkle, Eric] Univ Houston, Human Genet Ctr & Divof Epidemiol, Houston, TX 77025 USA. [Ingelsson, Erik] Uppsala Univ, Mol Epidemiol & Sci Life Lab, Dept Med Sci, S-75105 Uppsala, Sweden. [Jaervelin, Marjo-Riitta] Univ Oulu, Inst Hlth Sci, FI-90014 Oulu, Finland. [Jaervelin, Marjo-Riitta] Univ Oulu, Bioctr Oulu, FI-90014 Oulu, Finland. [Jaervelin, Marjo-Riitta] Natl Inst Hlth & Welf, Dept Children & Young People & Families, FI-90101 Oulu, Finland. [Jaervelin, Marjo-Riitta] Oulu Univ Hosp, Unit Primary Care, FI-90220 Oulu, Finland. [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Sorensen, Thorkild I. A.] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark. [Sorensen, Thorkild I. A.] Capital Reg, Bispebjerg & Frederiksberg Hosp, Inst Prevent Med, DK-2000 Frederiksberg, Denmark. [Strachan, David P.] Univ London, Div Populat Hlth Sci & Educ, London SW17 0RE, England. [Zygmunt, Marek] Univ Med Greifswald, Dept Obstet & Gynecol, D-17475 Greifswald, Germany. [Murabito, Joanne M.] Boston Univ, Sch Med, Dept Med, Gen Internal Med Sect, Boston, MA 02118 USA. [Ong, Ken K.] Univ Cambridge, Dept Paediat, Cambridge CB2 0QQ, England. RP Perry, JRB (reprint author), Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Inst Metab Sci, Box 285 Cambridge Biomed Campus, Cambridge CB2 0QQ, England. EM john.perry@mrc-epid.cam.ac.uk; Murabito@bu.edu RI Magnusson, Patrik/C-4458-2017; Grioni, Sara/K-5320-2016; Wright, Margaret/A-4560-2016; Fox, Laura /C-6249-2016; Bowtell, David/H-1007-2016; Smith, Albert/K-5150-2015; mangino, massimo/F-5134-2011; d'Adamo, Adamo Pio/G-4064-2011; Johnson, Andrew/G-6520-2013; Franke, Lude/P-7036-2016; Ormel, Johan/C-6094-2013; Wijmenga, Cisca/D-2173-2009; Davey Smith, George/A-7407-2013; Brenner, Hermann/B-4627-2017; Deloukas, Panos/B-2922-2013; Rivadeneira, Fernando/O-5385-2015; Stockl, Doris/B-5352-2014; Hypponen, Elina/B-2596-2014; Knight, Julia/A-6843-2012; Colaus, PsyColaus/K-6607-2013; Visser, Jenny /F-8156-2011; Garcia-Closas, Montserrat /F-3871-2015; Gudnason, Vilmundur/K-6885-2015; Pahkala, Katja/D-7449-2013; Ripatti, Samuli/H-9446-2014; Atsma, F./L-4178-2015; Montgomery, Grant/B-7148-2008 OI Jarvelin, Marjo-Riitta/0000-0002-2149-0630; Cox, Angela/0000-0002-5138-1099; Timpson, Nicholas/0000-0002-7141-9189; Lawlor, Debbie A/0000-0002-6793-2262; Dunning, Alison Margaret/0000-0001-6651-7166; Eriksson, Johan/0000-0002-2516-2060; Giles, Graham/0000-0003-4946-9099; Bergmann, Sven/0000-0002-6785-9034; Paternoster, Lavinia/0000-0003-2514-0889; Gieger, Christian/0000-0001-6986-9554; Zeggini, Eleftheria/0000-0003-4238-659X; Kiel, Douglas/0000-0001-8474-0310; Sacerdote, Carlotta/0000-0002-8008-5096; Karasik, David/0000-0002-8826-0530; Wolffenbuttel, Bruce H.R./0000-0001-9262-6921; Forouhi, Nita/0000-0002-5041-248X; de Geus, Eco/0000-0001-6022-2666; Martin, Nicholas/0000-0003-4069-8020; Dobrovic, Alexander/0000-0003-3414-112X; Ganna, Andrea/0000-0002-8147-240X; Grioni, Sara/0000-0002-5891-8426; Devilee, Peter/0000-0002-8023-2009; Day, Felix/0000-0003-3789-7651; Murray, Anna/0000-0002-2351-2522; Esko, Tonu/0000-0003-1982-6569; Franks, Paul/0000-0002-0520-7604; Nevanlinna, Heli/0000-0002-0916-2976; Ziad Alizadeh, Behrooz/0000-0002-1415-8007; Magi, Reedik/0000-0002-2964-6011; Czene, Kamila/0000-0002-3233-5695; Wright, Margaret/0000-0001-7133-4970; Bowtell, David/0000-0001-9089-7525; Smith, Albert/0000-0003-1942-5845; mangino, massimo/0000-0002-2167-7470; d'Adamo, Adamo Pio/0000-0001-9367-4909; Franke, Lude/0000-0002-5159-8802; Davey Smith, George/0000-0002-1407-8314; Brenner, Hermann/0000-0002-6129-1572; Deloukas, Panos/0000-0001-9251-070X; Rivadeneira, Fernando/0000-0001-9435-9441; Hypponen, Elina/0000-0003-3670-9399; Garcia-Closas, Montserrat /0000-0003-1033-2650; Gudnason, Vilmundur/0000-0001-5696-0084; Ripatti, Samuli/0000-0002-0504-1202; Montgomery, Grant/0000-0002-4140-8139 FU Cancer Research UK [10118, 10124]; Medical Research Council [G0401527, G0701863, G1000143, G9815508, MC_PC_15018, MC_U106179471, MC_U106179472, MC_UU_12013/1, MC_UU_12013/3, MC_UU_12015/1, MC_UU_12015/2, MR/J012165/1]; NCATS NIH HHS [UL1 TR001108]; NCI NIH HHS [P50 CA116201]; NIA NIH HHS [R01 AG041517, U01 AG049505]; NINDS NIH HHS [R01 NS017950]; Wellcome Trust [098381, 102215] NR 77 TC 95 Z9 95 U1 9 U2 77 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD OCT 2 PY 2014 VL 514 IS 7520 BP 92 EP + DI 10.1038/nature13545 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AP9SS UT WOS:000342420800042 PM 25231870 ER PT J AU Santos, MA Faryabi, RB Ergen, AV Day, AM Malhowski, A Canela, A Onozawa, M Lee, JE Callen, E Gutierrez-Martinez, P Chen, HT Wong, N Finkel, N Deshpande, A Sharrow, S Rossi, DJ Ito, K Ge, K Aplan, PD Armstrong, SA Nussenzweig, A AF Santos, Margarida A. Faryabi, Robert B. Ergen, Aysegul V. Day, Amanda M. Malhowski, Amy Canela, Andres Onozawa, Masahiro Lee, Ji-Eun Callen, Elsa Gutierrez-Martinez, Paula Chen, Hua-Tang Wong, Nancy Finkel, Nadia Deshpande, Aniruddha Sharrow, Susan Rossi, Derrick J. Ito, Keisuke Ge, Kai Aplan, Peter D. Armstrong, Scott A. Nussenzweig, Andre TI DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier SO NATURE LA English DT Article ID HEMATOPOIETIC STEM-CELLS; OXIDATIVE STRESS; RNA-SEQ; MLL; PROGENITORS; BREAKS; RESISTANCE; DISCOVERY; LYMPHOMA; RENEWAL AB Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells(1). Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation of reactive oxygen species and DNA double-strand breaks(2-4), we speculated that DNA damage might also constrain leukaemic self-renewal and malignant haematopoiesis. Here we show that the histone methyl-transferase MLL4, a suppressor of B-cell lymphoma(5,6), is required for stem-cell activity and an aggressive form of acutemyeloid leukaemia harbouring the MLL-AF9 oncogene. Deletion of MLL4 enhances myelopoiesis and myeloid differentiation of leukaemic blasts, which protects mice from death related to acute myeloid leukaemia. MLL4 exerts its function by regulating transcriptional programs associated with the antioxidant response. Addition of reactive oxygen species scavengers or ectopic expression of FOXO3 protects MLL-/- MLL-AF9 cells from DNA damage and inhibits myeloid maturation. Similar to MLL4 deficiency, loss of ATM or BRCA1 sensitizes transformed cells to differentiation, suggesting that myeloid differentiation is promoted by loss of genome integrity. Indeed, we show that restriction-enzyme-induced double-strand breaks are sufficient to induce differentiation of MLL-AF9 blasts, which requires cyclin-dependent kinase inhibitor p21(Cip1) (Cdkn1a) activity. In summary, we have uncovered an unexpected tumour-promoting role of genome guardians in enforcing the oncogene-induced differentiation blockade in acute myeloid leukaemia. C1 [Santos, Margarida A.; Faryabi, Robert B.; Ergen, Aysegul V.; Day, Amanda M.; Malhowski, Amy; Canela, Andres; Callen, Elsa; Chen, Hua-Tang; Wong, Nancy; Finkel, Nadia; Nussenzweig, Andre] NCI, Lab Genome Integr, NIH, Bethesda, MD 20892 USA. [Onozawa, Masahiro; Aplan, Peter D.] NCI, Genet Branch, NIH, Bethesda, MD 20892 USA. [Lee, Ji-Eun; Ge, Kai] NIDDKD, Lab Endocrinol & Receptor Biol, NIH, Bethesda, MD 20892 USA. [Gutierrez-Martinez, Paula; Rossi, Derrick J.] Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA. [Gutierrez-Martinez, Paula; Rossi, Derrick J.] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA. [Deshpande, Aniruddha; Armstrong, Scott A.] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA. [Deshpande, Aniruddha; Armstrong, Scott A.] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA. [Sharrow, Susan] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA. [Ito, Keisuke] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Dept Cell Biol, Bronx, NY 10461 USA. [Ito, Keisuke] Albert Einstein Coll Med, Dept Med, Albert Einstein Canc Ctr, Bronx, NY 10461 USA. RP Nussenzweig, A (reprint author), NCI, Lab Genome Integr, NIH, Bethesda, MD 20892 USA. EM andre_nussenzweig@nih.gov RI Lee, Ji-Eun/F-7891-2011; Faryabi, Robert/H-3544-2015; Aplan, Peter/K-9064-2016; OI Lee, Ji-Eun/0000-0002-3768-7016; Faryabi, Robert/0000-0002-7931-2175; Ge, Kai/0000-0002-7442-5138 FU Leukemia and Lymphoma Society; National Cancer Institute [CA66996, CA140575]; National Institutes of Health; National Cancer Institute; Center for Cancer Research; Ellison Medical Foundation FX We thank all members of the A. Nussenzweig laboratory, J. Daniel and P. Love for discussions; L. Granger for flow cytometry; M. J. Kruhlak for microscopy; K. Zhao for RNA sequencing; R. Anderson and K. Smith for animal care; K. Naka for the FOXO3 retrovirus; G. Legube for the pBABE-AsiSI-ER plasmid; J. Zuber for pLEPG and pRT3GEPIR plasmids; O. Fernandez-Capetillo for ATRi; and S. John for suggestions. S. A. A. was supported by the Leukemia and Lymphoma Society and National Cancer Institute grants CA66996 and CA140575. This work was supported by the Intramural Research Program of the National Institutes of Health, the National Cancer Institute and the Center for Cancer Research, and an Ellison Medical Foundation Senior Scholar in Aging Award to A.N. NR 40 TC 41 Z9 42 U1 4 U2 59 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD OCT 2 PY 2014 VL 514 IS 7520 BP 107 EP + DI 10.1038/nature13483 PG 23 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AP9SS UT WOS:000342420800045 PM 25079327 ER PT J AU Behforouz, HL Drain, PK Rhatigan, JJ AF Behforouz, Heidi L. Drain, Paul K. Rhatigan, Joseph J. TI BECOMING A PHYSICIAN Rethinking the Social History SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material C1 [Behforouz, Heidi L.; Rhatigan, Joseph J.] Brigham & Womens Hosp, Dept Med, Div Global Hlth Equ, Boston, MA 02115 USA. [Drain, Paul K.] Massachusetts Gen Hosp, Dept Med, Div Infect Dis, Boston, MA 02114 USA. [Drain, Paul K.] Massachusetts Gen Hosp, Dept Med, Med Practice Evaluat Ctr, Boston, MA 02114 USA. [Behforouz, Heidi L.; Drain, Paul K.; Rhatigan, Joseph J.] Harvard Univ, Sch Med, Boston, MA USA. RP Behforouz, HL (reprint author), Brigham & Womens Hosp, Dept Med, Div Global Hlth Equ, 75 Francis St, Boston, MA 02115 USA. NR 5 TC 23 Z9 24 U1 0 U2 5 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 2 PY 2014 VL 371 IS 14 BP 1277 EP 1279 DI 10.1056/NEJMp1404846 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AP9VS UT WOS:000342429800003 PM 25271600 ER PT J AU Lionetti, E Castellaneta, S Francavilla, R Pulvirenti, A Tonutti, E Amarri, S Barbato, M Barbera, C Barera, G Bellantoni, A Castellano, E Guariso, G Limongelli, MG Pellegrino, S Polloni, C Ughi, C Zuin, G Fasano, A Catassi, C AF Lionetti, Elena Castellaneta, Stefania Francavilla, Ruggiero Pulvirenti, Alfredo Tonutti, Elio Amarri, Sergio Barbato, Maria Barbera, Cristiana Barera, Graziano Bellantoni, Antonella Castellano, Emanuela Guariso, Graziella Limongelli, Maria Giovanna Pellegrino, Salvatore Polloni, Carlo Ughi, Claudio Zuin, Giovanna Fasano, Alessio Catassi, Carlo CA SIGENP Italian Soc Pediat Gastroen TI Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID NATURAL-HISTORY; PEDIATRIC-GASTROENTEROLOGY; ISLET AUTOIMMUNITY; FAMILY-RISK; FOLLOW-UP; PREVALENCE; NUTRITION; INFANTS; INTERVENTION; POPULATION AB BACKGROUND The relationship between the risk of celiac disease and both the age at which gluten is introduced to a child's diet and a child's early dietary pattern is unclear. METHODS We randomly assigned 832 newborns who had a first-degree relative with celiac disease to the introduction of dietary gluten at 6 months (group A) or 12 months (group B). The HLA genotype was determined at 15 months of age, and serologic screening for celiac disease was evaluated at 15, 24, and 36 months and at 5, 8, and 10 years. Patients with positive serologic findings underwent intestinal biopsies. The primary outcome was the prevalence of celiac disease autoimmunity and of overt celiac disease among the children at 5 years of age. RESULTS Of the 707 participants who remained in the trial at 36 months, 553 had a standard-risk or high-risk HLA genotype and completed the study. At 2 years of age, significantly higher proportions of children in group A than in group B had celiac disease autoimmunity (16% vs. 7%, P = 0.002) and overt celiac disease (12% vs. 5%, P = 0.01). At 5 years of age, the between-group differences were no longer significant for autoimmunity (21% in group A and 20% in group B, P = 0.59) or overt disease (16% and 16%, P = 0.78 by the log-rank test). At 10 years, the risk of celiac disease autoimmunity was far higher among children with high-risk HLA than among those with standard-risk HLA (38% vs. 19%, P = 0.001), as was the risk of overt celiac disease (26% vs. 16%, P = 0.05). Other variables, including breast-feeding, were not associated with the development of celiac disease. CONCLUSIONS Neither the delayed introduction of gluten nor breast-feeding modified the risk of celiac disease among at-risk infants, although the later introduction of gluten was associated with a delayed onset of disease. A high-risk HLA genotype was an important predictor of disease. (Funded by the Fondazione Celiachia of the Italian Society for Celiac Disease; CELIPREV ClinicalTrials.gov number, NCT00639444.) C1 [Lionetti, Elena] Univ Catania, Dept Pediat, I-95124 Catania, Italy. [Pulvirenti, Alfredo] Univ Catania, Dept Clin & Mol Biomed, I-95124 Catania, Italy. [Castellaneta, Stefania] San Paolo Hosp, Dept Pediat, Milan, Italy. [Francavilla, Ruggiero] Univ Bari, Dept Dev Biomed, Bari, Italy. [Tonutti, Elio] Udine Hosp, Dept Immunopathol & Allergol, Udine, Italy. [Amarri, Sergio] Azienda Osped IRCCS Santa Maria Nuova Hosp, Dept Pediat, Reggio Emilia, Italy. [Barbato, Maria] Univ Roma La Sapienza, Dept Pediat, I-00185 Rome, Italy. [Barbera, Cristiana] Univ Turin, Dept Pediat, I-10124 Turin, Italy. [Barera, Graziano] Hosp San Raffaele, Dept Pediat, Milan, Italy. [Zuin, Giovanna] Vittore Buzzi Childrens Hosp, Dept Pediat, Milan, Italy. [Bellantoni, Antonella] Bianchi Melacrino Morelli Hosp, Dept Pediat, Reggio Di Calabria, Italy. [Castellano, Emanuela] Ist Giannina Gaslini, Pediat Gastroenterol Unit, I-16148 Genoa, Italy. [Guariso, Graziella] Univ Padua, Dept Pediat, Padua, Italy. [Limongelli, Maria Giovanna] Univ Naples Federico II, Dept Pediat, Naples, Italy. [Polloni, Carlo] Rovereto Hosp, Dept Pediat, Rovereto, Trento, Italy. [Ughi, Claudio] Univ Pisa, Dept Pediat, Pisa, Italy. [Catassi, Carlo] Marche Polytech Univ, Dept Pediat, I-60123 Ancona, Italy. [Fasano, Alessio] MassGen Hosp Children, Div Pediat Gastroenterol & Nutr, Boston, MA USA. [Fasano, Alessio] MassGen Hosp Children, Ctr Celiac Res, Boston, MA USA. [Fasano, Alessio; Catassi, Carlo] Harvard Univ, Sch Med, Celiac Program, Boston, MA USA. RP Catassi, C (reprint author), Marche Polytech Univ, Dept Pediat, Via F Corridoni 1, I-60123 Ancona, Italy. EM catassi@univpm.it OI Francavilla, Ruggiero/0000-0002-4603-974X; Pellegrino, Salvatore/0000-0003-1163-0748 FU Fondazione Celiachia of the Italian Society for Celiac Disease FX Funded by the Fondazione Celiachia of the Italian Society for Celiac Disease; CELIPREV ClinicalTrials.gov number, NCT00639444.) NR 36 TC 106 Z9 110 U1 6 U2 44 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 2 PY 2014 VL 371 IS 14 BP 1295 EP 1303 DI 10.1056/NEJMoa1400697 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AP9VS UT WOS:000342429800006 PM 25271602 ER PT J AU Shapiro, L Whelan, P Magro, C AF Shapiro, Lee Whelan, Patrick Magro, Cynthia TI Case 18-2014: A Man with a Rash, Myalgia, and Weakness SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID MALIGNANT ATROPHIC PAPULOSIS; DISEASE C1 [Shapiro, Lee] Albany Med Coll, Albany, NY 12208 USA. [Whelan, Patrick] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Magro, Cynthia] Weill Cornell Med Coll, New York, NY USA. RP Shapiro, L (reprint author), Albany Med Coll, Albany, NY 12208 USA. EM leeshapiromd@gmail.com NR 4 TC 1 Z9 1 U1 0 U2 1 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 2 PY 2014 VL 371 IS 14 BP 1361 EP 1361 DI 10.1056/NEJMc1409657 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AP9VS UT WOS:000342429800022 PM 25271617 ER PT J AU Stone, JH AF Stone, John H. TI Case 18-2014: A Man with a Rash, Myalgia, and Weakness Reply SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 Massachusetts Gen Hosp, Boston, MA 02114 USA. RP Stone, JH (reprint author), Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. 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Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E58 EP E59 PG 2 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400129 ER PT J AU Anderson, CE Stewart, L AF Anderson, Cristan E. Stewart, Lygia TI Hyperbilirubinemia and complicated acute cholecystitis: improving preoperative diagnostic strategies SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 San Francisco VA Med Ctr, San Francisco, CA USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E114 EP E114 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400273 ER PT J AU Caragacianu, D Pakdaman, MN Kamani, D Randolph, GW AF Caragacianu, Diana Pakdaman, Michael N. Kamani, Dipti Randolph, Gregory W. TI Clinical characteristics of lymph node metastases in papillary thyroid carcinoma SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [Caragacianu, Diana; Pakdaman, Michael N.; Kamani, Dipti; Randolph, Gregory W.] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E84 EP E85 PG 2 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400195 ER PT J AU Chang, PH AF Chang, Philip H. TI Treatment of foreign pediatric patients with chronic burn wounds with a delayed closure protocol SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [Chang, Philip H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E42 EP E42 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400091 ER PT J AU Gfrerer, L Mattos, D Mastroianni, M Ricci, JA Weng, C Winograd, J Cetrulo, CL Austen, WG Liao, EC AF Gfrerer, Lisa Mattos, David Mastroianni, Melissa Ricci, Joseph A. Weng, Christina Winograd, Jon Cetrulo, Curtis L., Jr. Austen, William G., Jr. Liao, Eric C. TI Impact of surgeon and surgical team on outcomes in immediate implant based breast reconstruction (IBR) SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [Gfrerer, Lisa; Mattos, David; Mastroianni, Melissa; Ricci, Joseph A.; Weng, Christina; Winograd, Jon; Cetrulo, Curtis L., Jr.; Austen, William G., Jr.; Liao, Eric C.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E152 EP E152 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400369 ER PT J AU Gibbs, VC Pelletreau, B Wiebe, R AF Gibbs, Verna C. Pelletreau, Barbara Wiebe, Robert TI Large-scale system-wide success with an ACCOUNTing process to eliminate surgical sponge retention SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 Dign Hlth, San Francisco, CA USA. San Francisco VA Med Ctr, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E35 EP E36 PG 2 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400078 ER PT J AU Gunnar, WP Wilson, MA Smith, T AF Gunnar, William P. Wilson, Mark A. Smith, Tracy TI Three year analysis of the surgical complexity model in the Veterans Health Administration (VHA) SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [Gunnar, William P.; Wilson, Mark A.; Smith, Tracy] US Dept Vet Affairs, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E141 EP E142 PG 2 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400340 ER PT J AU Guyette, JP Moser, PT Charest, JM Ott, HC AF Guyette, Jacques P. Moser, Philipp T. Charest, Jonathan M. Ott, Harald C. TI Generation of functional human myocardium from native human heart matrix and human induced pluripotent stem (iPS) derived cardiomyocytes SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [Guyette, Jacques P.; Moser, Philipp T.; Charest, Jonathan M.; Ott, Harald C.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E49 EP E49 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400108 ER PT J AU Lanuti, M Zhou, HY Wu, CC Mino-Kenudson, M Chen, W Mathisen, DJ AF Lanuti, Michael Zhou, Haiyu Wu, Carol C. Mino-Kenudson, Mari Chen, Wen Mathisen, Douglas J. TI Driver mutation status in resected stage I lung adenocarcinoma: correlation with chest computed tomography findings SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [Lanuti, Michael; Zhou, Haiyu; Wu, Carol C.; Mino-Kenudson, Mari; Chen, Wen; Mathisen, Douglas J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E5 EP E5 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400013 ER PT J AU Ng, JH Fairbairn, NG Meppelink, AM Bodugoz-Senturk, H Randolph, MA Muratoglu, OK Redmond, RW AF Ng, Joanna H. Fairbairn, Neil G. Meppelink, Amanda M. Bodugoz-Senturk, Hatice Randolph, Mark A. Muratoglu, Orhun K. Redmond, Robert W. TI A photochemical tissue bonding approach for rapid sutureless microvascular anastomosis with minimal inflammation in an arterial graft model SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [Ng, Joanna H.; Fairbairn, Neil G.; Meppelink, Amanda M.; Bodugoz-Senturk, Hatice; Randolph, Mark A.; Muratoglu, Orhun K.; Redmond, Robert W.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E139 EP E140 PG 3 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400335 ER PT J AU Nurudeen, SM Gifty, K Haynes, AB Lipsitz, S Gawande, AA Berry, W AF Nurudeen, Suliat M. Gifty, Kwakye Haynes, Alex B. Lipsitz, Stuart Gawande, Atul A. 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Phitayakorn, Roy TI Quality of life in patients treated for Cushing's syndrome SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 Cushings Support & Res Fdn, Plymouth, MA USA. Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. Boston Univ, Sch Med, Boston, MA 02118 USA. Univ Autonoma Barcelona, Hosp St Pau, E-08193 Barcelona, Spain. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E11 EP E12 PG 2 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400026 ER PT J AU Saha, S Shaik, M Berbiglia, L Saha, SK Johnston, G Dhar, V Singh, T Arora, M Wiese, D AF Saha, Sukamal Shaik, Mohammed Berbiglia, Lindsay Saha, Supriya K. Johnston, Gregory Dhar, Vikrom Singh, Trevor Arora, Madan Wiese, David TI Tumor size predicts long term survival in colon cancer: an analysis of the National Cancer Data Base SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 McLaren Med Ctr, Flint, MI USA. Detroit Med Ctr, Detroit, MI USA. Dana Farber Canc Inst, Boston, MA 02115 USA. Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E77 EP E77 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400176 ER PT J AU Sanfey, HA Fromson, JA Mellinger, JD Rakinic, J Williams, M Williams, B AF Sanfey, Hilary A. Fromson, John A. Mellinger, John D. Rakinic, Jan Williams, Michael Williams, Betsy TI Surgeons in difficulty: an exploration of behavior differences among male and female surgeons SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 Massachusetts Gen Hosp, Boston, MA 02114 USA. So Illinois Univ, Carbondale, IL 62901 USA. Profess Renewal Ctr, Lawrence, KS USA. Rush Univ, Chicago, IL 60612 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E141 EP E141 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400339 ER PT J AU Smith, AD Adler, JT Nguyen, LL AF Smith, Ann D. Adler, Joel T. Nguyen, Louis L. TI Analysis of optimal initial and subsequent interventions in the treatment of critical limb ischemia SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 Brigham & Womens Hosp, Boston, MA 02115 USA. Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E57 EP E58 PG 2 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400126 ER PT J AU Tanabe, KK Maheswaran, S Wang, JP Xega, K Stowell, CP Ferrone, CR Haber, DA Ting, DT AF Tanabe, Kenneth K. Maheswaran, Shyamala Wang, Jjiping Xega, Kristina Stowell, Christopher P. Ferrone, Christina R. Haber, Daniel A. Ting, David T. TI Evaluation of autotransfusion during resection of colorectal carcinoma liver metastases (CRCLM): are circulating tumor cells (CTCs) a problem? SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 Massachusetts Gen Hosp, Boston, MA 02114 USA. Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E172 EP E172 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400422 ER PT J AU Zimmet, J Kaiser, E Tseng, E Shunk, K AF Zimmet, Jeffrey Kaiser, Erhard Tseng, Elaine Shunk, Kendrick TI Successful Percutaneous Management of Partial Avulsion of the Native Aortic Valve Complex Complicating Transcatheter Aortic Valve Replacement SO JOURNAL OF INVASIVE CARDIOLOGY LA English DT Article DE balloon aortic valvuloplasty; aortic valve stenosis ID HIGH-RISK; VALVULOPLASTY; IMPLANTATION; RUPTURE AB This is the first reported case of partial aortic valve and annulus rupture during transcatheter aortic valve replacement, and its successful management through percutaneous means. It stresses the fact that even severe procedural complications can often be treated by a heart team endovascularly, without requiring sternotomy. C1 [Zimmet, Jeffrey] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Tseng, Elaine] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA. [Zimmet, Jeffrey] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Kaiser, Erhard] Kardiol Privatarztpraxis, Frankfurt, Germany. RP Zimmet, J (reprint author), San Francisco VA Med Ctr, 4150 Clement St,Cardiol 111C, San Francisco, CA 94121 USA. EM Jeffrey.Zimmet@va.gov FU Edwards Lifesciences; University of California; Coulter Foundation; Siemens Medical Systems; TransAortic Medical Inc. FX The authors have completed and returned the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Zimmet reports no disclosures. Dr Kaiser reports personal fees from Edwards Lifesciences. Dr Tseng reports grants from University of California and the Coulter Foundation. Dr Shunk reports a grant from Siemens Medical Systems and consulting fees from TransAortic Medical Inc. NR 11 TC 0 Z9 0 U1 0 U2 0 PU H M P COMMUNICATIONS PI MALVERN PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA SN 1042-3931 EI 1557-2501 J9 J INVASIVE CARDIOL JI J. Invasive Cardiol. PD OCT PY 2014 VL 26 IS 10 BP E137 EP E140 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CN1SH UT WOS:000358199900002 PM 25274870 ER PT J AU Raghuraman, N March, MI Hacker, MR Modest, AM Wenger, J Narcisse, R David, JL Scott, J Rana, S AF Raghuraman, Nandini March, Melissa I. Hacker, Michele R. Modest, Anna Merport Wenger, Julia Narcisse, Rulx David, Jean Louis Scott, Jennifer Rana, Sarosh TI Adverse maternal and fetal outcomes and deaths related to preeclampsia and eclampsia in Haiti SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH LA English DT Article DE Preeclampsia; Eclampsia; Adverse maternal and perinatal outcomes; Haiti ID SUSPECTED PREECLAMPSIA; COUNTRIES; PRETERM; WOMEN; RISK AB Objective: The purpose of this study was to define the prevalence and clinical characteristics of preeclampsia and eclampsia at a hospital in rural Haiti. Methods: This is a retrospective review of women presenting to Hopital Albert Schweitzer (HAS) in Deschapelles, Haiti with singleton pregnancy and diagnosis of preeclampsia or eclampsia from January 1, 2011 through December 31, 2012. Hospital charts were reviewed to obtain medical and prenatal history, hospital course, delivery information, and fetal/neonatal outcomes. The outcomes included placental abruption, antepartum eclampsia, postpartum eclampsia, maternal death, birthweight <2500 g and stillbirth. Data are presented as median (quartile 1, quartile 3) or n (%) and risk ratios. Results: During the study period, 1743 women were admitted to the maternity service at HAS and 290 (16.6%) were diagnosed with preeclampsia or eclampsia. Only singleton pregnancies were analyzed (N = 270). Nearly all (95.0%) patients admitted with preeclampsia had severe preeclampsia. There were 83 patients with eclampsia (30.7%) of which 61 (73.4%) had antepartum eclampsia. There were 48 stillbirths (17.8%) and 5 maternal deaths (1.9%). Patients with antepartum eclampsia were younger, more likely to be nulliparous and had less prenatal care compared to women with antepartum preeclampsia. Antepartum eclampsia was associated with placental abruption and maternal death. Conclusions: The rates of preeclampsia and its associated complications, such as eclampsia, placental abruption, maternal death and stillbirth, are high at this facility in Haiti. Such data are essential to developing region-specific systems to prevent preeclampsia-related complications. (C) 2014 International Society for the Study of Hypertension in Pregnancy Published by Elsevier B.V. All rights reserved. C1 [Raghuraman, Nandini; March, Melissa I.; Hacker, Michele R.; Modest, Anna Merport; Scott, Jennifer; Rana, Sarosh] Beth Israel Deaconess Med Ctr, Dept Obstet & Gynecol, Boston, MA 02215 USA. [March, Melissa I.; Rana, Sarosh] Beth Israel Deaconess Med Ctr, Div Maternal Fetal Med, Boston, MA 02215 USA. [March, Melissa I.; Hacker, Michele R.; Wenger, Julia; Rana, Sarosh] Harvard Univ, Sch Med, Boston, MA USA. [Wenger, Julia] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Narcisse, Rulx; David, Jean Louis] Hosp Albert Schweitzer, Dept Obstet & Gynecol, Deschapelles, Haiti. [Scott, Jennifer] Brigham & Womens Hosp, Div Womens Hlth, Boston, MA 02115 USA. [Scott, Jennifer] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. RP Rana, S (reprint author), Univ Chicago, Dept Obstet & Gynecol, MC 20505841 S Maryland Ave, Chicago, IL 60637 USA. EM srana1@bidmc.harvard.edu OI Hacker, Michele/0000-0003-0217-9991 NR 18 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2210-7789 J9 PREGNANCY HYPERTENS JI Pregnancy Hypertens. PD OCT PY 2014 VL 4 IS 4 BP 279 EP 286 DI 10.1016/j.preghy.2014.09.002 PG 8 WC Obstetrics & Gynecology; Peripheral Vascular Disease SC Obstetrics & Gynecology; Cardiovascular System & Cardiology GA CN1XF UT WOS:000358213400007 PM 26104817 ER PT J AU Alonso, A Yin, XY Roetker, NS Magnani, JW Kronmal, RA Ellinor, PT Chen, LY Lubitz, SA McClelland, RL McManus, DD Soliman, EZ Huxley, RR Nazarian, S Szklo, M Heckbert, SR Benjamin, EJ AF Alonso, Alvaro Yin, Xiaoyan Roetker, Nicholas S. Magnani, Jared W. Kronmal, Richard A. Ellinor, Patrick T. Chen, Lin Y. Lubitz, Steven A. McClelland, Robyn L. McManus, David D. Soliman, Elsayed Z. Huxley, Rachel R. Nazarian, Saman Szklo, Moyses Heckbert, Susan R. Benjamin, Emelia J. TI Blood Lipids and the Incidence of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis and the Framingham Heart Study SO JOURNAL OF THE AMERICAN HEART ASSOCIATION LA English DT Article DE atrial fibrillation; cholesterol; epidemiology; lipids; risk factors ID DENSITY-LIPOPROTEIN CHOLESTEROL; RANDOMIZED CONTROLLED-TRIALS; NIIGATA PREVENTIVE MEDICINE; RISK-FACTORS; NATRIURETIC PEPTIDE; METABOLIC SYNDROME; SUBCLINICAL CVD; ASSOCIATION; DISEASE; ADULTS AB Background-Dyslipidemia is a major contributor to the development of atherosclerosis and coronary disease. Its role in the etiology of atrial fibrillation (AF) is uncertain. Methods and Results-We studied 7142 men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Framingham Heart Study who did not have prevalent AF at baseline and were not on lipid-lowering medications. Total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol, and triglycerides were measured using standard procedures. Incident AF during follow-up was identified from hospital discharge codes; review of medical charts; study electrocardiograms; and, in MESA only, Medicare claims. Multivariable Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals of AF by clinical categories of blood lipids in each cohort. Study-specific results were meta-analyzed using inverse of variance weighting. During 9.6 years of mean follow-up, 480 AF cases were identified. In a combined analysis of multivariable-adjusted results from both cohorts, high levels of high-density lipoprotein cholesterol were associated with lower AF risk (hazard ratio 0.64, 95% CI 0.48 to 0.87 in those with levels >= 60 mg/dL versus <40 mg/dL), whereas high triglycerides were associated with higher risk of AF (hazard ratio 1.60, 95% CI 1.25 to 2.05 in those with levels >= 200 mg/dL versus <150 mg/dL). Total cholesterol and low-density lipoprotein cholesterol were not associated with the risk of AF. Conclusion-In these 2 community-based cohorts, high-density lipoprotein cholesterol and triglycerides but not low-density lipoprotein cholesterol or total cholesterol were associated with the risk of AF, accounting for other cardiometabolic risk factors. C1 [Alonso, Alvaro; Roetker, Nicholas S.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA. [Magnani, Jared W.; Benjamin, Emelia J.] Boston Univ, Sect Cardiovasc Med, Dept Med, Boston, MA 02215 USA. [Yin, Xiaoyan] Boston Univ, Dept Biostat, Boston, MA 02215 USA. [Yin, Xiaoyan; Magnani, Jared W.; McManus, David D.; Benjamin, Emelia J.] NHLBI, Framingham, MA USA. [Yin, Xiaoyan; Magnani, Jared W.; McManus, David D.; Benjamin, Emelia J.] Boston Univ Framingham Heart Study, Framingham, MA USA. [Kronmal, Richard A.; McClelland, Robyn L.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Heckbert, Susan R.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Ellinor, Patrick T.; Lubitz, Steven A.] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA USA. [Ellinor, Patrick T.; Lubitz, Steven A.] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA. [Chen, Lin Y.] Univ Minnesota, Sch Med, Dept Med, Div Cardiovasc, Minneapolis, MN 55455 USA. [McManus, David D.] Univ Massachusetts, Sch Med, Dept Med, Div Cardiol, Worcester, MA USA. [Soliman, Elsayed Z.] Wake Forest Sch Med, Dept Epidemiol & Prevent, Epidemiol Cardiol Res Ctr, Winston Salem, NC USA. [Huxley, Rachel R.] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia. [Nazarian, Saman] Johns Hopkins Univ, Dept Med Cardiol, Baltimore, MD USA. [Nazarian, Saman; Szklo, Moyses] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Benjamin, Emelia J.] Boston Univ, Dept Epidemiol, Sch Publ Hlth, Boston, MA USA. RP Alonso, A (reprint author), Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, 1200 S 2nd St,Suite 300, Minneapolis, MN 55454 USA. EM alonso@umn.edu RI Huxley, Rachel/C-7032-2013; Huxley, Rachel/J-4638-2013; Alonso, Alvaro/A-4917-2010; OI Huxley, Rachel/0000-0002-2705-6616; Huxley, Rachel/0000-0002-2705-6616; Alonso, Alvaro/0000-0002-2225-8323; Benjamin, Emelia/0000-0003-4076-2336 FU National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169]; National Center for Research Resources [UL1-TR-000040, UL1-RR-025005]; National Institutes of Health [2R01HL092577, 1R01HL102214, 1RC1HL 101056, 6R01NS17950, K23HL114724, N01HC25195] FX MESA: This research was supported by contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-RR-025005 from the National Center for Research Resources. FHS: This work was supported by grants 2R01HL092577, 1R01HL102214, 1RC1HL 101056, 6R01NS17950, K23HL114724, and N01HC25195 from the National Institutes of Health. NR 38 TC 9 Z9 9 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2047-9980 J9 J AM HEART ASSOC JI J. Am. Heart Assoc. PD OCT PY 2014 VL 3 IS 5 AR e001211 DI 10.1161/JAHA.114.001211 PG 20 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CM0VL UT WOS:000357396800028 PM 25292185 ER PT J AU Wasfy, JH Strom, JB Waldo, SW O'Brien, C Wimmer, NJ Zai, AH Luttrell, J Spertus, JA Kennedy, KF Normand, SLT Mauri, L Yeh, RW AF Wasfy, Jason H. Strom, Jordan B. Waldo, Stephen W. O'Brien, Cashel Wimmer, Neil J. Zai, Adrian H. Luttrell, Jennifer Spertus, John A. Kennedy, Kevin F. Normand, Sharon-Lise T. Mauri, Laura Yeh, Robert W. TI Clinical Preventability of 30-Day Readmission After Percutaneous Coronary Intervention SO JOURNAL OF THE AMERICAN HEART ASSOCIATION LA English DT Article DE Readmission; Performance Metrics; Percutaneous Coronary Intervention; Quality Improvement; Outcomes Research ID SHORT-TERM READMISSION; HOSPITAL READMISSIONS; MEDICINE AB Background-Early readmission after PCI is an important contributor to healthcare expenditures and a target for performance measurement. The extent to which 30-day readmissions after PCI are preventable is unknown yet essential to minimizing their occurrence. Methods and Results-PCI patients readmitted to hospital at which PCI was performed within 30 days of discharge at the Massachusetts General Hospital and Brigham and Women's Hospital were identified, and their medical records were independently reviewed by 2 physicians. Each reviewer used an ordinal scale (0, not; 1, possibly; 2, probably; and 3, definitely preventable) to rate clinical preventability, and a total sum score >= 2 was considered preventable. Characteristics of preventable and unpreventable readmissions were compared, and predictors of clinical preventability were assessed by using multivariate logistic regression. Of 9288 PCIs performed, 9081 (97.8%) patients survived to initial hospital discharge and 1007 (11.1%) were readmitted to the index hospital within 30 days. After excluding repeat readmissions, 893 readmissions were reviewed. Fair agreement between physician reviewers was observed (weighted kappa statistic 0.44 [95% CI 0.39 to 0.49]). After aggregation of scores, 380 (42.6%) readmissions were deemed preventable and 513 (57.4%) were deemed not preventable. Common causes of preventable readmissions included staged PCI without new symptoms (14.7%), vascular/bleeding complications of PCI (10.0%), and congestive heart failure (9.7%). Conclusions-Nearly half of 30-day readmissions after PCI may have been prevented by changes in clinical decision-making. Focusing on these readmissions may reduce readmission rates. C1 [Wasfy, Jason H.; Waldo, Stephen W.; O'Brien, Cashel; Yeh, Robert W.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cardiol Div,Dept Med, Boston, MA 02114 USA. [Strom, Jordan B.; Mauri, Laura] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Boston, MA 02114 USA. [Zai, Adrian H.; Luttrell, Jennifer] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Comp Sci Lab, Boston, MA 02114 USA. [Wimmer, Neil J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Cardiovasc Div,Dept Med, Boston, MA 02115 USA. [Spertus, John A.; Kennedy, Kevin F.] Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO 64110 USA. [Normand, Sharon-Lise T.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Normand, Sharon-Lise T.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Mauri, Laura; Yeh, Robert W.] Harvard Clin Res Inst, Boston, MA USA. RP Yeh, RW (reprint author), Massachusetts Gen Hosp, Div Cardiol, GRB 8-843,55 Fruit St, Boston, MA 02114 USA. EM ryeh@partners.org FU Massachusetts Department of Public Health; American Heart Association [12CRP9010016]; Hassenfeld Scholars Program FX This work was supported in part by the Massachusetts Department of Public Health, a grant from the American Heart Association (12CRP9010016), and the support of the Hassenfeld Scholars Program. NR 19 TC 8 Z9 8 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2047-9980 J9 J AM HEART ASSOC JI J. Am. Heart Assoc. PD OCT PY 2014 VL 3 IS 5 AR e001290 DI 10.1161/JAHA.114.001290 PG 11 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CM0VL UT WOS:000357396800036 PM 25261531 ER PT J AU Womack, JA Chang, CCH So-Armah, KA Alcorn, C Baker, JV Brown, ST Budoff, M Butt, AA Gibert, C Goetz, MB Gottdiener, J Gottlieb, S Justice, AC Leaf, D McGinnis, K Rimland, D Rodriguez-Barradas, MC Sico, J Skanderson, M Tindle, H Tracy, RP Warner, A Freiberg, MS AF Womack, Julie A. Chang, Chung-Chou H. So-Armah, Kaku A. Alcorn, Charles Baker, Jason V. Brown, Sheldon T. Budoff, Matthew Butt, Adeel A. Gibert, Cynthia Goetz, Matthew Bidwell Gottdiener, John Gottlieb, Stephen Justice, Amy C. Leaf, David McGinnis, Kathleen Rimland, David Rodriguez-Barradas, Maria C. Sico, Jason Skanderson, Melissa Tindle, Hilary Tracy, Russell P. Warner, Alberta Freiberg, Matthew S. TI HIV Infection and Cardiovascular Disease in Women SO JOURNAL OF THE AMERICAN HEART ASSOCIATION LA English DT Article DE AIDS; CVD risk factors; Women ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACUTE MYOCARDIAL-INFARCTION; CORONARY-HEART-DISEASE; IMMUNE ACTIVATION; RISK-FACTORS; HEALTH; VETERANS; COHORT; ATHEROSCLEROSIS; POPULATION AB Background-HIV infection is associated with increased risk of cardiovascular disease (CVD) in men. Whether HIV is an independent risk factor for CVD in women has not yet been established. Methods and Results-We analyzed data from the Veterans Aging Cohort Study on 2187 women (32% HIV infected [HIV+]) who were free of CVD at baseline. Participants were followed from their first clinical encounter on or after April 01, 2003 until a CVD event, death, or the last follow-up date (December 31, 2009). The primary outcome was CVD (acute myocardial infarction [AMI], unstable angina, ischemic stroke, and heart failure). CVD events were defined using clinical data, International Classification of Diseases, Ninth Revision, Clinical Modification codes, and/or death certificate data. We used Cox proportional hazards models to assess the association between HIV and incident CVD, adjusting for age, race/ethnicity, lipids, smoking, blood pressure, diabetes, renal disease, obesity, hepatitis C, and substance use/abuse. Median follow-up time was 6.0 years. Mean age at baseline of HIV+ and HIV uninfected (HIV-) women was 44.0 versus 43.2 years (P<0.05). Median time to CVD event was 3.1 versus 3.7 years (P=0.11). There were 86 incident CVD events (53%, HIV+): AMI, 13%; unstable angina, 8%; ischemic stroke, 22%; and heart failure, 57%. Incident CVD/1000 person-years was significantly higher among HIV+ (13.5; 95% confidence interval [CI]= 10.1, 18.1) than HIV- women (5.3; 95% CI=3.9, 7.3; P<0.001). HIV+ women had an increased risk of CVD, compared to HIV- (hazard ratio=2.8; 95% CI=1.7, 4.6; P<0.001). Conclusions-HIV is associated with an increased risk of CVD in women. C1 [Womack, Julie A.] Yale Univ, Sch Nursing, West Haven, CT 06516 USA. [Chang, Chung-Chou H.; Butt, Adeel A.; Tindle, Hilary] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. [Chang, Chung-Chou H.; Alcorn, Charles] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA. [So-Armah, Kaku A.; Justice, Amy C.; Sico, Jason] Yale Univ, Sch Med, New Haven, CT USA. [Baker, Jason V.] Univ Minnesota, Dept Med, Hennepin Cty Med Ctr, Minneapolis, MN 55455 USA. [Brown, Sheldon T.] James J Peters VA Med Ctr, Bronx, NY USA. [Brown, Sheldon T.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Budoff, Matthew] Harbor UCLA Med Ctr, Los Angeles, CA USA. [Budoff, Matthew] Los Angeles Biomed Res Inst, Los Angeles, CA USA. [Butt, Adeel A.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Butt, Adeel A.] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates. [Gibert, Cynthia] VA Med Ctr, Washington, DC USA. [Gibert, Cynthia] George Washington Univ, Sch Med, Washington, DC USA. [Goetz, Matthew Bidwell; Leaf, David; Warner, Alberta] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Goetz, Matthew Bidwell; Leaf, David; Warner, Alberta] VA Greater Los Angeles Hlth Care Syst, Los Angeles, CA USA. [Gottdiener, John; Gottlieb, Stephen] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Justice, Amy C.; McGinnis, Kathleen; Sico, Jason; Skanderson, Melissa] Vet Affairs Connecticut Hlth Care Syst, West Haven Vet Adm Med Ctr, West Haven, CT USA. [Rimland, David] Emory Univ, Sch Med, Atlanta, GA USA. [Rimland, David] Atlanta VA Med Ctr, Atlanta, GA USA. [Rodriguez-Barradas, Maria C.] Michael E DeBakey VA Med Ctr, Infect Dis Sect, Houston, TX USA. [Rodriguez-Barradas, Maria C.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Tracy, Russell P.] Univ Vermont, Coll Med, Burlington, VT USA. [Freiberg, Matthew S.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. RP Womack, JA (reprint author), Yale Univ, Sch Nursing, Yale Univ West Campus,POB 27399,300 Heffernan Dr, West Haven, CT 06516 USA. EM julie.womack@yale.edu OI Butt, Adeel/0000-0002-1118-1826 FU Yale Center for Clinical Investigation and the Clinical and Translational Science Award from the National Center for Research Resources of the National Institutes of Health (NIH) [UL1 RR024139]; National Institute of Nursing Research of the National Institutes of Health (NIH) [K01 NR013437]; National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) [HL095136]; National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH) [AA013566-10, AA020790, AA020794] FX This work was supported by the Yale Center for Clinical Investigation and the Clinical and Translational Science Award Grant No. UL1 RR024139 from the National Center for Research Resources; National Institute of Nursing Research Grant No. K01 NR013437; National Heart, Lung and Blood Institute Grant No. HL095136; and the National Institute on Alcohol Abuse and Alcoholism Grant Nos. AA013566-10, AA020790, and AA020794, all components of the National Institutes of Health (NIH). NR 26 TC 20 Z9 20 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2047-9980 J9 J AM HEART ASSOC JI J. Am. Heart Assoc. PD OCT PY 2014 VL 3 IS 5 AR e001035 DI 10.1161/JAHA.114.001035 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CM0VL UT WOS:000357396800013 PM 25324353 ER PT J AU Shin, H Kim, TH Yoo, JY Zhao, JJ Lydon, JP Ha, UH Jeong, JW AF Shin, Heesung Kim, Tae Hoon Yoo, Jung-Yoon Zhao, Jean J. Lydon, John P. Ha, Un-Hwan Jeong, Jae-Wook TI The role of Pik3ca in uterine gland morphogenesis and fertility in mice SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Shin, Heesung; Kim, Tae Hoon; Yoo, Jung-Yoon; Jeong, Jae-Wook] Michigan State Univ, Grand Rapids, MI USA. [Zhao, Jean J.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lydon, John P.] Baylor Coll Med, Houston, TX 77030 USA. [Ha, Un-Hwan] Korea Univ, Yeongi, Chungnam, South Korea. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 94 DI 10.1158/1538-7445.AM2014-94 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900093 ER PT J AU Abazeed, M Adams, D Tamayo, P Meyerson, M Hammerman, P Schreiber, S AF Abazeed, Mohamed Adams, Drew Tamayo, Pablo Meyerson, Matthew Hammerman, Peter Schreiber, Stuart TI The radiogenomic landscape of cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Abazeed, Mohamed] Cleveland Clin Fdn, Cleveland, OH 44195 USA. [Adams, Drew; Tamayo, Pablo; Schreiber, Stuart] Broad Inst, Boston, MA USA. [Meyerson, Matthew; Hammerman, Peter] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4259 DI 10.1158/1538-7445.AM2014-4259 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910202235 ER PT J AU Abo, RP Garcia, EP Ducar, M Adusumilli, R Breneiser, M Rojas-Rudilla, V Sholl, LM Lindeman, NI Meyerson, ML Hahn, WC Van Hummelen, P MacConaill, LE AF Abo, Ryan P. Garcia, Elizabeth P. Ducar, Matthew Adusumilli, Ravali Breneiser, Marc Rojas-Rudilla, Vanessa Sholl, Lynette M. Lindeman, Neal I. Meyerson, Matthew L. Hahn, William C. Van Hummelen, Paul MacConaill, Laura E. TI BreaKmer: Detection of structural rearrangements in targeted next-generation sequencing data using kmers SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Abo, Ryan P.; Ducar, Matthew; Adusumilli, Ravali; Breneiser, Marc; Meyerson, Matthew L.; Hahn, William C.; Van Hummelen, Paul; MacConaill, Laura E.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Garcia, Elizabeth P.; Rojas-Rudilla, Vanessa; Sholl, Lynette M.; Lindeman, Neal I.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5321 DI 10.1158/1538-7445.AM2014-5321 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204242 ER PT J AU Aceto, N Bardia, A Spencer, JA Wittner, BS Yu, M Donaldson, MC Pely, A Engstrom, A Zhu, HL Brannigan, BW Kapur, R Stott, SL Shioda, T Ramaswamy, S Ting, DT Lin, CP Toner, M Haber, DA Maheswaran, S AF Aceto, Nicola Bardia, Aditya Spencer, Joel A. Wittner, Ben S. Yu, Min Donaldson, Maria C. Pely, Adam Engstrom, Amanda Zhu, Huili Brannigan, Brian W. Kapur, Ravi Stott, Shannon L. Shioda, Toshi Ramaswamy, Sridhar Ting, David T. Lin, Charles P. Toner, Mehmet Haber, Daniel A. Maheswaran, Shyamala TI Circulating tumor cell clusters are precursors of breast cancer metastasis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Aceto, Nicola; Bardia, Aditya; Spencer, Joel A.; Wittner, Ben S.; Yu, Min; Donaldson, Maria C.; Pely, Adam; Engstrom, Amanda; Zhu, Huili; Brannigan, Brian W.; Kapur, Ravi; Stott, Shannon L.; Shioda, Toshi; Ramaswamy, Sridhar; Ting, David T.; Lin, Charles P.; Toner, Mehmet; Haber, Daniel A.; Maheswaran, Shyamala] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-192 DI 10.1158/1538-7445.AM2014-LB-192 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205225 ER PT J AU Adalsteinsson, VA Lohr, JG Cibulskis, K Choudhury, AD Rosenberg, M Cruz-Gordillo, P Francis, J Zhang, CZ Shalek, AK Satija, R Trombetta, JT Lu, DN Tallapragada, N Tahirova, NT Kim, S Blumenstiel, B Sougnez, C Auclair, D Van Allen, EM Nakabayashi, M Lis, RT Lee, GSM Li, TT Chabot, MS Taplin, ME Clancy, TE Loda, M Regev, A Meyerson, M Hahn, WC Kantoff, PW Golub, TR Getz, G Boehm, JS Love, JC AF Adalsteinsson, Viktor A. Lohr, Jens G. Cibulskis, Kristian Choudhury, Atish D. Rosenberg, Mara Cruz-Gordillo, Peter Francis, Joshua Zhang, ChengZhong Shalek, Alexander K. Satija, Rahul Trombetta, John T. Lu, Diana Tallapragada, Naren Tahirova, Narmin T. Kim, Sora Blumenstiel, Brendan Sougnez, Carrie Auclair, Daniel Van Allen, Eliezer M. Nakabayashi, Mari Lis, Rosina T. Lee, Gwo-Shu M. Li, Tiantian Chabot, Matthew S. Taplin, Mary-Ellen Clancy, Thomas E. Loda, Massimo Regev, Aviv Meyerson, Matthew Hahn, William C. Kantoff, Philip W. Golub, Todd R. Getz, Gad Boehm, Jesse S. Love, J. Christopher TI Whole exome sequencing of CTCs as a window into metastatic cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Adalsteinsson, Viktor A.; Tallapragada, Naren; Tahirova, Narmin T.; Love, J. Christopher] Koch Inst, Boston, MA USA. [Lohr, Jens G.; Cibulskis, Kristian; Rosenberg, Mara; Cruz-Gordillo, Peter; Francis, Joshua; Zhang, ChengZhong; Shalek, Alexander K.; Satija, Rahul; Trombetta, John T.; Lu, Diana; Kim, Sora; Blumenstiel, Brendan; Sougnez, Carrie; Van Allen, Eliezer M.; Regev, Aviv; Golub, Todd R.; Getz, Gad; Boehm, Jesse S.] Broad Inst, Boston, MA USA. [Choudhury, Atish D.; Nakabayashi, Mari; Lis, Rosina T.; Lee, Gwo-Shu M.; Li, Tiantian; Chabot, Matthew S.; Taplin, Mary-Ellen; Clancy, Thomas E.; Loda, Massimo; Meyerson, Matthew; Hahn, William C.; Kantoff, Philip W.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Auclair, Daniel] Multiple Myeloma Res Fdn, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 993 DI 10.1158/1538-7445.AM2014-993 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905461 ER PT J AU Agarwal, A Carey, A Traer, E Tyner, J Bagby, GC Druker, BJ AF Agarwal, Anupriya Carey, Alyssa Traer, Elie Tyner, Jeffrey Bagby, Grover C. Druker, Brian J. TI Targeted suppression of interleukin-1 signaling inhibits growth of primary human acute myeloid leukemia cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Agarwal, Anupriya; Carey, Alyssa; Traer, Elie; Bagby, Grover C.] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Hematol & Med Oncol, Portland, OR 97201 USA. [Tyner, Jeffrey] Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Knight Canc Inst, Portland, OR 97201 USA. [Bagby, Grover C.] Portland VA Med Ctr, Portland, OR 97201 USA. [Druker, Brian J.] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA. [Druker, Brian J.] Howard Hughes Med Inst, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5248 DI 10.1158/1538-7445.AM2014-5248 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204198 ER PT J AU Akbay, EA Tchaicha, JH Altabef, A Mikse, OR Kikuchi, E Rhee, K Liao, R Bronson, RT Sholl, LM Meyerson, M Hammerman, PS Wong, KK AF Akbay, Esra A. Tchaicha, Jeremy H. Altabef, Abigail Mikse, Oliver R. Kikuchi, Eiki Rhee, Kevin Liao, Rachel Bronson, Roderick T. Sholl, Lynette M. Meyerson, Matthew Hammerman, Peter S. Wong, Kwok-Kin TI Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Akbay, Esra A.; Tchaicha, Jeremy H.; Altabef, Abigail; Mikse, Oliver R.; Kikuchi, Eiki; Rhee, Kevin; Meyerson, Matthew; Hammerman, Peter S.; Wong, Kwok-Kin] Dana Farber Canc Inst, Boston, MA 02115 USA. [Liao, Rachel] Broad Inst, Cambridge, MA USA. [Bronson, Roderick T.] Harvard Univ, Sch Med, Boston, MA USA. [Sholl, Lynette M.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4851 DI 10.1158/1538-7445.AM2014-4851 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203315 ER PT J AU Anders, L Guenther, MG Qi, J Fan, ZP Marineau, JJ Rahl, PB Loven, J Sigova, AA Smith, WB Lee, TI Bradner, JE Young, RA AF Anders, Lars Guenther, Matthew G. Qi, Jun Fan, Zi Peng Marineau, Jason J. Rahl, Peter B. Loven, Jakob Sigova, Alla A. Smith, William B. Lee, Tong Ihn Bradner, James E. Young, Richard A. TI Genome-wide localization of anti-cancer drugs SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Anders, Lars; Guenther, Matthew G.; Fan, Zi Peng; Rahl, Peter B.; Loven, Jakob; Sigova, Alla A.; Lee, Tong Ihn; Young, Richard A.] Whitehead Inst, Cambridge, MA 02142 USA. [Qi, Jun; Marineau, Jason J.; Smith, William B.; Bradner, James E.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3230 DI 10.1158/1538-7445.AM2014-3230 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200234 ER PT J AU Bae, J Prabhala, R Carrasco, R Richardson, P Dranoff, G Anderson, KC Munshi, NC AF Bae, Jooeun Prabhala, Rao Carrasco, Ruben Richardson, Paul Dranoff, Glen Anderson, Kenneth C. Munshi, Nikhil C. TI Lenalidomide treatment enhances the anti-tumor activities of XBP1 specific cytotoxic T lymphocytes by increasing the frequency and tumor-specific response of central memory CD3+CD8+T cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Bae, Jooeun; Prabhala, Rao; Carrasco, Ruben; Richardson, Paul; Dranoff, Glen; Anderson, Kenneth C.; Munshi, Nikhil C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 638 DI 10.1158/1538-7445.AM2014-638 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905100 ER PT J AU Bae, J Prabhala, R Carrasco, R Lee, AH Kimmelman, A Anderson, KC Munshi, N AF Bae, Jooeun Prabhala, Rao Carrasco, Ruben Lee, Ann-Hwee Kimmelman, Alec Anderson, Kenneth C. Munshi, Nikhil TI Novel heteroclitic XBP1 peptides induce antigen-specific memory CD3+CD8+T cells expressing critical T cell markers and transcription regulators SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Bae, Jooeun; Prabhala, Rao; Carrasco, Ruben; Kimmelman, Alec; Anderson, Kenneth C.; Munshi, Nikhil] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Lee, Ann-Hwee] Weill Cornell Med Coll, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2894 DI 10.1158/1538-7445.AM2014-2894 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904160 ER PT J AU Bahcall, M Sasaki, T Ogino, A Capelletti, M Butaney, M Janne, PA AF Bahcall, Magda Sasaki, Takaaki Ogino, Atsuko Capelletti, Marzia Butaney, Mohit Jaenne, Pasi A. TI Overexpression of the adaptor protein CRKL as a mechanism of acquired resistance to Crizotinib in ALK-positive NSCLC SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Bahcall, Magda; Sasaki, Takaaki; Ogino, Atsuko; Capelletti, Marzia; Butaney, Mohit; Jaenne, Pasi A.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 1 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3716 DI 10.1158/1538-7445.AM2014-3716 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201207 ER PT J AU Bainer, R Yui, Y Mumenthaler, S Mallick, P Podlaha, O Michor, F Liphardt, J Licht, J Weaver, V AF Bainer, Russell Yui, Yoshihiro Mumenthaler, Shannon Mallick, Parag Podlaha, Ondrej Michor, Franziska Liphardt, Jan Licht, Jonathan Weaver, Valerie TI 3D extracellular stiffness cues drive localized changes in gene expression SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Bainer, Russell; Yui, Yoshihiro; Weaver, Valerie] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Mumenthaler, Shannon] Univ So Calif, Los Angeles, CA USA. [Mallick, Parag; Liphardt, Jan] Stanford Univ, Palo Alto, CA 94304 USA. [Podlaha, Ondrej; Michor, Franziska] Dana Farber Canc Inst, Boston, MA 02115 USA. [Licht, Jonathan] Northwestern Univ, Chicago, IL 60611 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2344 DI 10.1158/1538-7445.AM2014-2344 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903067 ER PT J AU Barclay, LA Lee, S Stewart, ML Braun, CR Bird, GH Walensky, LD AF Barclay, Lauren A. Lee, Susan Stewart, Michelle L. Braun, Craig R. Bird, Gregory H. Walensky, Loren D. TI A noncanonical mechanism for BCL-2 inhibition of pro-apoptotic BAX SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Barclay, Lauren A.; Lee, Susan; Stewart, Michelle L.; Braun, Craig R.; Bird, Gregory H.; Walensky, Loren D.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2954 DI 10.1158/1538-7445.AM2014-2954 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904226 ER PT J AU Bendell, JC LoRusso, P Cho, DC Musib, L Yan, YB Chang, I Patel, P Chang, IT Meng, RD Shapiro, GI AF Bendell, Johanna C. LoRusso, Patricia Cho, Daniel C. Musib, Luna Yan, Yibing Chang, Ilsung Patel, Premal Chang, Iris T. Meng, Raymond D. Shapiro, Geoffrey I. TI Clinical results of a phase Ib dose-escalation study of the Mek inhibitor cobimetinib (GDC-0973) and the Akt inhibitor ipatasertib (GDC-0068) in patients (pts) with solid tumors SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Bendell, Johanna C.] Sarah Cannon Res Inst, Nashville, TN USA. [LoRusso, Patricia] Barbara Ann Karmanos Canc Inst, Detroit, MI USA. [Cho, Daniel C.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Musib, Luna; Yan, Yibing; Chang, Ilsung; Patel, Premal; Chang, Iris T.; Meng, Raymond D.] Genentech Inc, San Francisco, CA 94080 USA. [Shapiro, Geoffrey I.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT328 DI 10.1158/1538-7445.AM2014-CT328 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205093 ER PT J AU Bid, HK Phelps, DA Xiao, LL Baker, L Qi, J Houghton, PJ AF Bid, Hemant Kumar Phelps, Doris A. Xiao, Linlin Baker, Laurence Qi, Jun Houghton, Peter J. TI Targeting c-Myc in pediatric sarcoma xenografts with the BET bromodomain inhibitor, JQ1, disrupts angiogenesis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Bid, Hemant Kumar; Phelps, Doris A.; Xiao, Linlin; Houghton, Peter J.] Nationwide Childrens Hosp, Columbus, OH USA. [Baker, Laurence] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA. [Qi, Jun] Dana Farber Canc Ctr, Boston, MA USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 25 DI 10.1158/1538-7445.AM2014-25 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900025 ER PT J AU Botta, G Jane-Valbuena, J Wong, T Doench, J Garraway, LA AF Botta, Ginevra Jane-Valbuena, Judit Wong, Terence Doench, John Garraway, Levi A. TI Characterizing mechanisms of resistance to androgen deprivation in prostate cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Botta, Ginevra; Jane-Valbuena, Judit; Garraway, Levi A.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Wong, Terence; Doench, John] Broad Inst Harvard & MIT, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3216 DI 10.1158/1538-7445.AM2014-3316 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200316 ER PT J AU Bowden, M Sicinska, E Kulke, M Loda, M AF Bowden, Michaela Sicinska, Ewa Kulke, Matthew Loda, Massimo TI Understanding the role of the carcinoid associated fibroblasts in the neuroendocrine tumor microenvironment SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Bowden, Michaela; Sicinska, Ewa; Kulke, Matthew; Loda, Massimo] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 168 DI 10.1158/1538-7445.AM2014-168 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900166 ER PT J AU Brastianos, PK Carter, SL Santagata, S Taylor-Weiner, A Jones, RT Horowitz, PM Ligon, KL Seaone, J Martinez-Saez, E Tabernero, J Cahill, DP Paek, SH Dunn, IF Johnson, BE Choueiri, TK Rabin, MS Winer, EP Lin, NU Van Hummelen, P Stemmer-Rachamimov, A Beroukhim, R Louis, DL Batchelor, TT Baselga, J Getz, G Hahn, WC AF Brastianos, Priscilla K. Carter, Scott L. Santagata, Sandro Taylor-Weiner, Amaro Jones, Robert T. Horowitz, Peleg M. Ligon, Keith L. Seaone, Joan Martinez-Saez, Elena Tabernero, Josep Cahill, Daniel P. Paek, Sun-Ha Dunn, Ian F. Johnson, Bruce E. Choueiri, Toni K. Rabin, Michael S. Winer, Eric P. Lin, Nancy U. Van Hummelen, Paul Stemmer-Rachamimov, Anat Beroukhim, Rameen Louis, David L. Batchelor, Tracy T. Baselga, Jose Getz, Gad Hahn, William C. TI Genomic characterization of 101 brain metastases and paired primary tumors reveals patterns of clonal evolution and selection of driver mutations SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 Massachusetts Gen Hosp, Boston, MA 02114 USA. Broad Inst, Cambridge, MA USA. Brigham & Womens Hosp, Boston, MA 02115 USA. Dana Farber Canc Inst, Boston, MA 02115 USA. Vall Hebron Univ Hosp, Barcelona, Spain. Seoul Natl Univ, Coll Med, Seoul, South Korea. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA NG03 DI 10.1158/1538-7445.AM2014-NG03 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205436 ER PT J AU Carey, CD Gusenleitner, D Chapuy, B Sun, H Ligon, A Kovach, AE Le, LP Sohani, AR Shipp, M Monti, S Rodig, SJ AF Carey, Christopher D. Gusenleitner, Daniel Chapuy, Bjoern Sun, Heather Ligon, Azra Kovach, Alexandra E. Le, Long P. Sohani, Aliyah R. Shipp, Margaret Monti, Stefano Rodig, Scott J. TI A targeted molecular classifier of MYC activity and BCL-2 expression in aggressive B-cell lymphomas, designed for clinical practice SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Carey, Christopher D.; Sun, Heather; Ligon, Azra; Rodig, Scott J.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Gusenleitner, Daniel; Monti, Stefano] Boston Univ, Sch Med, Sect Computat Biomed, Boston, MA 02118 USA. [Chapuy, Bjoern; Shipp, Margaret] Dana Farber Canc Inst, Boston, MA 02115 USA. [Kovach, Alexandra E.; Le, Long P.; Sohani, Aliyah R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5582 DI 10.1158/1538-7445.AM2014-5582 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204496 ER PT J AU Carter, SL Brastianos, PK McFadden, DG Papagiannakopoulos, T Taylor-Weiner, A Cibulskis, K Jacks, T Hahn, W Getz, G AF Carter, Scott L. Brastianos, Priscilla K. McFadden, David G. Papagiannakopoulos, Thales Taylor-Weiner, Amaro Cibulskis, Kristian Jacks, Tyler Hahn, William Getz, Gad TI Modes of metastasis evolution in human and murine cancer revealed by whole exome sequencing SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Carter, Scott L.; Taylor-Weiner, Amaro; Cibulskis, Kristian; Getz, Gad] Broad Inst, Cambridge, MA USA. [Brastianos, Priscilla K.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [McFadden, David G.; Papagiannakopoulos, Thales; Jacks, Tyler] MIT, Cambridge, MA 02139 USA. [Hahn, William] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3992 DI 10.1158/1538-7445.AM2014-3992 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201476 ER PT J AU Castel, P Juric, D Won, H Ainscough, B Ellis, H Ebbesen, S Griffith, M Griffith, O Gopakumar, I Sgroi, D Isakoff, S Mardis, E Solit, D Lowe, S Quadt, C Peters, M Berger, M Scaltriti, M Baselga, J AF Castel, Pau Juric, Dejan Won, Helen Ainscough, Benjamin Ellis, Haley Ebbesen, Saya Griffith, Malachi Griffith, Obi Gopakumar, Iyer Sgroi, Dennis Isakoff, Steven Mardis, Elaine Solit, David Lowe, Scott Quadt, Cornelia Peters, Malte Berger, Michael Scaltriti, Maurizio Baselga, Jose TI Loss of PTEN leads to clinical resistance to the PI3K alpha inhibitor BYL719 and provides evidence of convergent evolution under selective therapeutic pressure SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Castel, Pau; Won, Helen; Ellis, Haley; Ebbesen, Saya; Gopakumar, Iyer; Solit, David; Lowe, Scott; Berger, Michael; Scaltriti, Maurizio; Baselga, Jose] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Juric, Dejan; Sgroi, Dennis; Isakoff, Steven] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Ainscough, Benjamin; Griffith, Malachi; Griffith, Obi; Mardis, Elaine] Washington Univ, St Louis, MO USA. [Quadt, Cornelia] Novartis Pharmaceut, E Hanover, NJ USA. [Peters, Malte] Novartis Pharmaceut, Basel, Switzerland. OI Castel, Pau/0000-0002-4972-4347 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-327 DI 10.1158/1538-7445.AM2014-LB-327 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205363 ER PT J AU Charlton, BM Giovannucci, E Fuchs, CS Missmer, SA Rosner, BA Wu, K Michels, KB AF Charlton, Brittany M. Giovannucci, Ed Fuchs, Charles S. Missmer, Stacey A. Rosner, Bernard A. Wu, Kana Michels, Karin B. TI A prospective study on oral contraceptive use and risk of colorectal adenomas SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Charlton, Brittany M.; Giovannucci, Ed; Wu, Kana] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Fuchs, Charles S.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Missmer, Stacey A.; Rosner, Bernard A.; Michels, Karin B.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2166 DI 10.1158/1538-7445.AM2014-2166 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902378 ER PT J AU Chattopadhyay, S Huang, C Mukherjee, S Yusuf, RZ Viswanathan, V Wittner, BS Gentry, J Shamji, A Ramaswamy, S Scadden, DT Schreiber, SL AF Chattopadhyay, Shrikanta Huang, Cherrie Mukherjee, Siddhartha Yusuf, Rushdia Z. Viswanathan, Vasanthi Wittner, Ben S. Gentry, Jeff Shamji, Alykhan Ramaswamy, Sridhar Scadden, David T. Schreiber, Stuart L. TI Therapeutic approaches to metastasis induced by mesenchymal stem cells in the tumor microenvironment SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Chattopadhyay, Shrikanta; Huang, Cherrie; Yusuf, Rushdia Z.; Wittner, Ben S.; Gentry, Jeff; Ramaswamy, Sridhar; Scadden, David T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Mukherjee, Siddhartha] Columbia Univ, New York, NY USA. [Viswanathan, Vasanthi; Shamji, Alykhan; Schreiber, Stuart L.] Broad Inst, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 181 DI 10.1158/1538-7445.AM2014-181 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900178 ER PT J AU Cheng, IC Caberto, C Beckman, K Lum-Jones, A Haiman, C Marchand, LL Stram, D Saxena, R AF Cheng, Iona C. Caberto, Christian Beckman, Kenneth Lum-Jones, Annette Haiman, Christopher Marchand, Loic L. Stram, Daniel Saxena, Richa TI Genetic association study of the mitochondrial genome and colorectal cancer risk: The Multiethnic Cohort SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Cheng, Iona C.] Canc Prevent Inst Calif, Fremont, CA USA. [Caberto, Christian; Lum-Jones, Annette; Marchand, Loic L.] Univ Hawaii, Honolulu, HI 96822 USA. [Beckman, Kenneth] Univ Minnesota, Minneapolis, MN USA. [Haiman, Christopher; Stram, Daniel] Univ So Calif, Los Angeles, CA USA. [Saxena, Richa] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 945 DI 10.1158/1538-7445.AM2014-945 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905409 ER PT J AU Chin, R Balk, SP Toker, A AF Chin, Rebecca Balk, Steve P. Toker, Alex TI PTEN-deficient tumors depend on Akt2 for maintenance SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Chin, Rebecca; Balk, Steve P.; Toker, Alex] Harvard Univ, Sch Med, BIDMC, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4421 DI 10.1158/1538-7445.AM2014-4421 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910202395 ER PT J AU Chipumuro, E Marco, E Zhang, TH Christensen, C Kwiatkowski, N Sharma, B Hatheway, C Altabef, A Abraham, BJ Wong, KK Yuan, GC Young, RA Gray, NS George, RE AF Chipumuro, Edmond Marco, Eugenio Zhang, Tinghu Christensen, Camilla Kwiatkowski, Nicholas Sharma, Bandana Hatheway, Clark Altabef, Abigail Abraham, Brian J. Wong, Kwok-Kin Yuan, Guo-Cheng Young, Richard A. Gray, Nathanael S. George, Rani E. TI Selective inhibition of CDK7 targets MYCN-driven transcriptional amplification in neuroblastoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Chipumuro, Edmond; Marco, Eugenio; Zhang, Tinghu; Christensen, Camilla; Sharma, Bandana; Hatheway, Clark; Altabef, Abigail; Wong, Kwok-Kin; Yuan, Guo-Cheng; Gray, Nathanael S.; George, Rani E.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Kwiatkowski, Nicholas; Abraham, Brian J.; Young, Richard A.] Whitehead Inst Biomed Res, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-125 DI 10.1158/1538-7445.AM2014-LB-125 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205158 ER PT J AU Chiyomaru, T Fukuhara, S Saini, S Majid, S Deng, G Shahryary, V Chang, I Tanaka, Y Enokida, H Nakagawa, M Dahiya, R Yamamura, S AF Chiyomaru, Takeshi Fukuhara, Shinichiro Saini, Sharanjot Majid, Shahana Deng, Guoren Shahryary, Varahram Chang, Inik Tanaka, Yuichiro Enokida, Hideki Nakagawa, Masayuki Dahiya, Rajvir Yamamura, Soichiro TI Long noncoding RNA HOTAIR is targeted and regulated by microRNA-141 in renal carcinoma cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Chiyomaru, Takeshi; Fukuhara, Shinichiro; Saini, Sharanjot; Majid, Shahana; Deng, Guoren; Shahryary, Varahram; Chang, Inik; Tanaka, Yuichiro; Dahiya, Rajvir; Yamamura, Soichiro] San Francisco VA Med Ctr, San Francisco, CA USA. [Enokida, Hideki; Nakagawa, Masayuki] Kagoshima Univ, Kagoshima 890, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4357 DI 10.1158/1538-7445.AM2014-4357 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910202333 ER PT J AU Choi, JE Sebastian, C Mostoslavsky, R AF Choi, Jee-Eun Sebastian, Carlos Mostoslavsky, Raul TI The role of glucose metabolism and SIRT6 in skin carcinogenesis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Choi, Jee-Eun] Harvard Univ, Sch Med, Biol & Biomed Sci Grad Program, Boston, MA USA. [Sebastian, Carlos; Mostoslavsky, Raul] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3366 DI 10.1158/1538-7445.AM2014-3366 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200366 ER PT J AU Coffee, EM Corcoran, RB Engelman, JA AF Coffee, Erin M. Corcoran, Ryan B. Engelman, Jeffrey A. TI Pre-treatment p-EGFR levels in tumors from a genetically engineered mouse model of BRAFV600E colorectal cancer predict response to combined BRAF/EGFR inhibition SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Coffee, Erin M.; Corcoran, Ryan B.; Engelman, Jeffrey A.] Massachusetts Gen Hosp, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3135 DI 10.1158/1538-7445.AM2014-3135 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200140 ER PT J AU Costa, C Ebi, H Faber, AC Nishtala, M Song, Y Benes, CH Engelman, JA AF Costa, Carlotta Ebi, Hiromichi Faber, Anthony C. Nishtala, Madhuri Song, Youngchul Benes, Cyril H. Engelman, Jeffrey A. TI Meausuring PIP3 reveals the unexpected role of p110B in luminal breast cancers SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Costa, Carlotta; Faber, Anthony C.; Nishtala, Madhuri; Song, Youngchul; Benes, Cyril H.; Engelman, Jeffrey A.] Massachusetts Gen Hosp, Charlestown, MA USA. [Ebi, Hiromichi] Kanazawa Univ, Kanazawa, Ishikawa, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2619 DI 10.1158/1538-7445.AM2014-2619 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903364 ER PT J AU Crochiere, ML Kashyap, T Klebanov, B Senapedis, W del Alamo, D Tamir, S Baloglu, E McCauley, D Carlson, R Kauffman, M Shacham, S Demetri, G Wagner, A Sicinska, E Gokhale, P Kohl, N Saur, A Landesman, Y AF Crochiere, Marsha L. Kashyap, Trinayan Klebanov, Boris Senapedis, William del Alamo, Diego Tamir, Sharon Baloglu, Erkan McCauley, Dilara Carlson, Robert Kauffman, Michael Shacham, Sharon Demetri, George Wagner, Andrew Sicinska, Ewa Gokhale, Prafulla Kohl, Nancy Saur, Amy Landesman, Yosef TI Selinexor (KPT-330), a novel selective inhibitor of nuclear export (SINE), shows single agent efficacy against alveolar soft part sarcoma (ASPS) in vivo SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Crochiere, Marsha L.; Kashyap, Trinayan; Klebanov, Boris; Senapedis, William; del Alamo, Diego; Tamir, Sharon; Baloglu, Erkan; McCauley, Dilara; Carlson, Robert; Kauffman, Michael; Shacham, Sharon; Landesman, Yosef] Karyopharm Therapeut, Natick, MA USA. [Demetri, George; Wagner, Andrew; Sicinska, Ewa; Gokhale, Prafulla; Kohl, Nancy; Saur, Amy] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 1 Z9 1 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3810 DI 10.1158/1538-7445.AM2014-3810 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201300 ER PT J AU Crompton, B Stewart, C Taylor-Weiner, A Alexa, G Kurek, K Calicchio, M Kiezun, A Carter, S Shukla, S Mehta, S Thorner, A De Torres, C Lavarino, C Sunol, M McKenna, A Sivachenko, A Cibulskis, K Lawrence, M Ambrogio, L Auclair, D Rosshandler, I Celis, ASCY Rivera, M Rodriguez-Galindo, C Fleming, M Golub, T Getz, G Mora, J Stegmaier, K AF Crompton, Brian Stewart, Chip Taylor-Weiner, Amaro Alexa, Gabriela Kurek, Kyle Calicchio, Monica Kiezun, Adam Carter, Scott Shukla, Sachet Mehta, Swapnil Thorner, Aaron De Torres, Carmen Lavarino, Cinzia Sunol, Mariona McKenna, Aaron Sivachenko, Andrey Cibulskis, Kristian Lawrence, Michael Ambrogio, Lauren Auclair, Daniel Rosshandler, Ivan Celis, Angela Schwarz-Cruz Y. Rivera, Miguel Rodriguez-Galindo, Carlos Fleming, Mark Golub, Todd Getz, Gad Mora, Jaume Stegmaier, Kimberly TI The genomic landscape of pediatric Ewing sarcoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Crompton, Brian; Alexa, Gabriela; Shukla, Sachet; Mehta, Swapnil; Thorner, Aaron; Rodriguez-Galindo, Carlos; Stegmaier, Kimberly] Dana Farber Canc Inst, Boston, MA 02115 USA. [Stewart, Chip; Taylor-Weiner, Amaro; Kiezun, Adam; Carter, Scott; McKenna, Aaron; Sivachenko, Andrey; Cibulskis, Kristian; Lawrence, Michael; Ambrogio, Lauren; Auclair, Daniel; Golub, Todd; Getz, Gad] Broad Inst, Cambridge, MA USA. [Kurek, Kyle; Calicchio, Monica; Fleming, Mark] Boston Childrens Hosp, Boston, MA USA. [De Torres, Carmen; Lavarino, Cinzia; Sunol, Mariona; Mora, Jaume] Hosp San Juan Dios, Barcelona, Spain. [Rosshandler, Ivan; Celis, Angela Schwarz-Cruz Y.] Inst Nacl Med Genom, Mexico City, DF, Mexico. [Rivera, Miguel] Massachusetts Gen Hosp, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 999 DI 10.1158/1538-7445.AM2014-999 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900225 ER PT J AU Dastur, A Benes, C AF Dastur, Anahita Benes, Cyril TI Study of the response of melanoma lines to BRAF/MEK inhibitors and combination drug treatments SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Dastur, Anahita; Benes, Cyril] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5523 DI 10.1158/1538-7445.AM2014-5523 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204439 ER PT J AU Daubriac, J Boucher, Y AF Daubriac, Julien Boucher, Yves TI Carcinoma-associated fibroblasts promote breast cancer cell invasion via IGF-1 and RhoA SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Daubriac, Julien; Boucher, Yves] Massachusetts Gen Hosp, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 175 DI 10.1158/1538-7445.AM2014-175 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900172 ER PT J AU Daud, AI Hamid, O Ribas, A Hodi, FS Hwu, WJ Kefford, R Wolchok, J Hersey, P Weber, JS Joseph, R Gangadhar, TC Dronca, RS Patnaik, A Zarour, H Joshua, AM Gergich, K Wu, DN Lunceford, JK Emancipator, K Dolled-Filhart, M Li, N Ebbinghaus, S Kang, SP Robert, C AF Daud, Adil I. Hamid, Omid Ribas, Antoni Hodi, F. Stephen Hwu, Wen-Jen Kefford, Richard Wolchok, Jedd Hersey, Peter Weber, Jeffrey S. Joseph, Richard Gangadhar, Tara C. Dronca, Roxana S. Patnaik, Amita Zarour, Hassane Joshua, Anthony M. Gergich, Kevin Wu, Dianna Lunceford, Jared K. Emancipator, Kenneth Dolled-Filhart, Marisa Li, Nicole Ebbinghaus, Scot Kang, S. Peter Robert, Caroline TI Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor PD-L1 expression with outcome SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Daud, Adil I.] UCSF, Sch Med, San Francisco, CA USA. [Hamid, Omid] Angeles Clin & Res Inst, Los Angeles, CA USA. [Ribas, Antoni] David Geffen UCLA Sch Med, Los Angeles, CA USA. [Hodi, F. Stephen] Dana Farber Canc Inst, Boston, MA 02115 USA. [Hwu, Wen-Jen] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Kefford, Richard; Hersey, Peter] Univ Sydney, Sydney, NSW 2006, Australia. [Weber, Jeffrey S.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Weber, Jeffrey S.] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Joseph, Richard] Mayo Clin, Ctr Canc, Jacksonville, FL 32224 USA. [Gangadhar, Tara C.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Joseph, Richard] Mayo Clin, Rochester, MN USA. [Patnaik, Amita] START, San Antonio, TX USA. [Zarour, Hassane] Univ Pittsburgh, Pittsburgh, PA USA. [Joshua, Anthony M.] Princess Margaret Canc Ctr, Toronto, ON, Canada. [Gergich, Kevin; Wu, Dianna; Li, Nicole; Ebbinghaus, Scot] Merck, North Wales, PA USA. [Lunceford, Jared K.; Emancipator, Kenneth; Dolled-Filhart, Marisa] Merck, Rahway, NJ USA. [Kang, S. Peter] Merck Res Labs, Kenilworth, NJ USA. [Robert, Caroline] Gustave Roussy, Villejuif, France. NR 0 TC 5 Z9 5 U1 2 U2 4 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT104 DI 10.1158/1538-7445.AM2014-CT104 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205029 ER PT J AU de Waal, LM Lewis, TA Gechijian, L Tsherniak, A Youngsaye, W Rees, M Mikse, O Hickey, M Faloon, P Tolliday, N Koehler, A Schenone, M Wong, K Shamji, A Munoz, B Schreiber, SL Greulich, H Meyerson, ML AF de Waal, Luc M. Lewis, Tim A. Gechijian, Lara Tsherniak, Aviad Youngsaye, Willmen Rees, Matthew Mikse, Oliver Hickey, Mark Faloon, Patrick Tolliday, Nicola Koehler, Angela Schenone, Monica Wong, Kwok Shamji, Alykhan Munoz, Benito Schreiber, Stuart L. Greulich, Heidi Meyerson, Matthew L. TI An integrated genomic characterization of the target of a small molecule identifies a novel cancer dependency SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [de Waal, Luc M.; Mikse, Oliver; Wong, Kwok; Greulich, Heidi; Meyerson, Matthew L.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lewis, Tim A.; Tsherniak, Aviad; Youngsaye, Willmen; Rees, Matthew; Hickey, Mark; Faloon, Patrick; Tolliday, Nicola; Koehler, Angela; Schenone, Monica; Shamji, Alykhan; Munoz, Benito; Schreiber, Stuart L.] Broad Inst Harvard & MIT, Cambridge, MA USA. [Gechijian, Lara] Wellesley Coll, Wellesley, MA 02181 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4596 DI 10.1158/1538-7445.AM2014-4596 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203070 ER PT J AU Depeille, P Henricks, LM van de Ven, R Lemmens, E Matli, M Haigis, KM Donner, D Warren, R Roose, JP AF Depeille, Philippe Henricks, Linda M. van de Ven, Robert Lemmens, Ed Matli, Mary Haigis, Kevin M. Donner, David Warren, Robert Roose, Jeroen P. TI The Ras exchange factor RasGRP1 opposes proliferative EGFR-SOS1 Ras signals and restricts intestinal epithelial cell growth SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Depeille, Philippe; Henricks, Linda M.; van de Ven, Robert; Lemmens, Ed; Matli, Mary; Donner, David; Warren, Robert; Roose, Jeroen P.] UCSF, San Francisco, CA USA. [Haigis, Kevin M.] Massachusetts Gen Hosp, Mol Pathol Unit, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-306 DI 10.1158/1538-7445.AM2014-LB-306 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205340 ER PT J AU DePeralta, DK Wei, L Harriman, G Greenwood, J Bhat, S Westlin, W Harwood, HJ Kapeller, R Tanabe, KK Fuchs, BC AF DePeralta, Danielle K. Wei, Lan Harriman, Geraldine Greenwood, Jeremy Bhat, Sathesh Westlin, William Harwood, H. James Kapeller, Rosana Tanabe, Kenneth K. Fuchs, Bryan C. TI Liver selective Acetyl-CoA Carboxylase inhibition by ND-654 decreases hepatocellular carcinoma development in cirrhotic rats SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [DePeralta, Danielle K.; Wei, Lan; Tanabe, Kenneth K.; Fuchs, Bryan C.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Harriman, Geraldine; Westlin, William; Harwood, H. James; Kapeller, Rosana] Nimbus Discovery, Cambridge, MA USA. [Greenwood, Jeremy; Bhat, Sathesh] Schrodinger, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1427 DI 10.1158/1538-7445.AM2014-1427 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901158 ER PT J AU Deschenes-Simard, X Kottakis, F Lessard, F Saint-Germain, E Bourdeau, V Bardeesy, N Ferbeyre, G AF Deschenes-Simard, Xavier Kottakis, Filippos Lessard, Frederic Saint-Germain, Emmanuelle Bourdeau, Veronique Bardeesy, Nabeel Ferbeyre, Gerardo TI Tumor suppressor activity of the ERK/MAPK signaling: inhibition of cell reprogramming by degradation of specific proteins SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Deschenes-Simard, Xavier; Lessard, Frederic; Saint-Germain, Emmanuelle; Bourdeau, Veronique; Ferbeyre, Gerardo] Univ Montreal, Montreal, PQ, Canada. [Kottakis, Filippos; Bardeesy, Nabeel] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Kottakis, Filippos; Bardeesy, Nabeel] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3895 DI 10.1158/1538-7445.AM2014-3895 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201383 ER PT J AU Devaraj, SGT Fiskus, W Sharma, S Qi, J Shah, B Schaub, LJ Rodriguez, M Liu, K Iyer, SP Bradner, JE Bhalla, KN AF Devaraj, Santhana G. T. Fiskus, Warren Sharma, Sunil Qi, Jun Shah, Bhavin Schaub, Leasha J. Rodriguez, Melissa Liu, Ka Iyer, Swaminathan P. Bradner, James E. Bhalla, Kapil N. TI HEXIM1 induction exerts a mechanistic role and is a biomarker of lethal activity of BRD4 antagonist against human AML cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Devaraj, Santhana G. T.; Fiskus, Warren; Shah, Bhavin; Schaub, Leasha J.; Rodriguez, Melissa; Liu, Ka; Iyer, Swaminathan P.; Bhalla, Kapil N.] Houston Methodist Res Inst, Houston, TX USA. [Sharma, Sunil] Huntsman Canc Inst, Salt Lake City, UT USA. [Qi, Jun; Bradner, James E.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3686 DI 10.1158/1538-7445.AM2014-3686 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201178 ER PT J AU Diaz-Flores, E Weng, JL Akutagawa, J Holmfeldt, L Chonghaile, T Letai, A Mullighan, C Braun, B Loh, M AF Diaz-Flores, Ernesto Weng, Julie Akutagawa, Jon Holmfeldt, Linda Chonghaile, Triona Letai, Anthony Mullighan, Charles Braun, Benjamin Loh, Mignon TI Targeting BCL-2 in hypodiploid acute lymphoblastic leukemia SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Diaz-Flores, Ernesto; Weng, Julie; Akutagawa, Jon; Braun, Benjamin; Loh, Mignon] UCSF, San Francisco, CA USA. [Holmfeldt, Linda; Mullighan, Charles] St Judes Children Hosp, Memphis, TN USA. [Chonghaile, Triona; Letai, Anthony] Dana Farber Canc Inst, Boston, MA 02115 USA. RI Ni Chonghaile, Triona/L-9418-2015 OI Ni Chonghaile, Triona/0000-0002-3041-4031 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 332 DI 10.1158/1538-7445.AM2014-332 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904300 ER PT J AU Dienstmann, R Dong, F Borger, D Santagata, DD Ellisen, LW Le, LP Iafrate, AJ AF Dienstmann, Rodrigo Dong, Fei Borger, Darrell Santagata, Dora Dias Ellisen, Leif W. Le, Long P. Iafrate, A. John TI Standardized decision support in next-generation sequencing (NGS) reports of somatic cancer variants SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Dienstmann, Rodrigo] Sage Bionetworks, Seattle, WA USA. [Dong, Fei; Santagata, Dora Dias; Le, Long P.; Iafrate, A. John] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Mol Pathol Lab, Boston, MA USA. [Borger, Darrell; Ellisen, Leif W.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4260 DI 10.1158/1538-7445.AM2014-4260 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910202236 ER PT J AU Dongdong, MA Nwokeji, A Lin, JH Tai, YT Munshi, N Handin, RI AF Dongdong, M. A. Nwokeji, Arinze Lin, Jianhong Tai, Yu-Tzu Munshi, Nikhil Handin, Robert I. TI Zebrafish embryos provide a permissive environment for the growth and dissemination of primary human myeloma and its precursor cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Dongdong, M. A.; Nwokeji, Arinze; Handin, Robert I.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Lin, Jianhong; Tai, Yu-Tzu; Munshi, Nikhil] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-38 DI 10.1158/1538-7445.AM2014-LB-38 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205372 ER PT J AU Dreijerink, K Conemans, E Cornelissen, C Van Blokland, M Mannstadt, M Pieterman, C Herder, WD Havekes, B Fliers, E Hermus, A Vriens, M Timmers, M Van der Wall, E Brown, M Van der Luijt, R van Diest, P Valk, G AF Dreijerink, Koen Conemans, Elfi Cornelissen, Chantal Van Blokland, Marja Mannstadt, Michael Pieterman, Carla Herder, Wouter D. Havekes, Bas Fliers, Eric Hermus, Ad Vriens, Menno Timmers, Marc Van der Wall, Elsken Brown, Myles Van der Luijt, Rob van Diest, Paul Valk, Gerlof TI Breast cancer predisposition in multiple endocrine neoplasia type 1 SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Dreijerink, Koen; Brown, Myles] Dana Farber Canc Inst, Boston, MA 02115 USA. [Conemans, Elfi; Cornelissen, Chantal; Van Blokland, Marja; Pieterman, Carla; Vriens, Menno; Timmers, Marc; Van der Wall, Elsken; Van der Luijt, Rob; van Diest, Paul; Valk, Gerlof] Univ Med Ctr Utrecht, Utrecht, Netherlands. [Mannstadt, Michael] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Herder, Wouter D.] Erasmus MC, Rotterdam, Netherlands. [Havekes, Bas] Univ Med Ctr, Maastricht, Netherlands. [Fliers, Eric] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Hermus, Ad] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. RI Hermus, A.R.M.M./H-8043-2014 NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1289 DI 10.1158/1538-7445.AM2014-1289 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901024 ER PT J AU Du, MM Jiao, S Rosse, SA Gala, M Abecasis, G Bezieau, S Brenner, H Casey, G Chang-Claude, J Gallinger, S Hudson, TJ Kury, S Marchand, LL Leal, SM Newcomb, PA Nickerson, DA Potter, JD Slattery, ML Hsu, L Chan, AT White, E Berndt, SI Peters, U AF Du, Mengmeng Jiao, Shuo Rosse, Stephanie A. Gala, Manish Abecasis, Goncalo Bezieau, Stephane Brenner, Hermann Casey, Graham Chang-Claude, Jenny Gallinger, Steven Hudson, Thomas J. Kuery, Sebastien Marchand, Loic L. Leal, Suzanne M. Newcomb, Polly A. Nickerson, Deborah A. Potter, John D. Slattery, Martha L. Hsu, Li Chan, Andrew T. White, Emily Berndt, Sonja I. Peters, Ulrike TI Fine-mapping of common genetic variants associated with colorectal tumor risk identified potential functional variants SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Du, Mengmeng; Jiao, Shuo; Rosse, Stephanie A.; Newcomb, Polly A.; Potter, John D.; Hsu, Li; White, Emily; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Gala, Manish; Chan, Andrew T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Abecasis, Goncalo] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Bezieau, Stephane; Kuery, Sebastien] CHU Nantes, F-44035 Nantes 01, France. [Brenner, Hermann; Chang-Claude, Jenny] German Canc Res Ctr, Heidelberg, Germany. [Casey, Graham] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Gallinger, Steven] Mt Sinai Hosp, Toronto, PE, Canada. [Hudson, Thomas J.] Univ Toronto, Toronto, ON, Canada. [Marchand, Loic L.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Leal, Suzanne M.] Baylor Coll Med, Houston, TX 77030 USA. [Nickerson, Deborah A.] Univ Washington, Seattle, WA 98195 USA. [Slattery, Martha L.] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA. [Berndt, Sonja I.] NCI, NIH, Bethesda, MD 20892 USA. RI KURY, Sebastien/G-5971-2015; Bezieau, stephane/G-5621-2015 OI KURY, Sebastien/0000-0001-5497-0465; Bezieau, stephane/0000-0003-0095-1319 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2190 DI 10.1158/1538-7445.AM2014-2190 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902401 ER PT J AU Dubovsky, JA Flynn, R Du, J Harrington, BK Zhong, YM Yang, C Towns, W Lehman, A Johnson, A Devine, S Jaglowski, S Serody, JS Murphy, WJ Munn, DH Luznik, L Hill, G MacDonald, KKP Maillard, I Koreth, J Cutler, C Soiffer, RJ Antin, JH Ritz, J Panoskaltsis-Mortari, A Byrd, JC Blazar, BR AF Dubovsky, Jason A. Flynn, Ryan Du, Jing Harrington, Bonnie K. Zhong, Yiming Yang, Carrie Towns, William Lehman, Amy Johnson, Amy Devine, Steven Jaglowski, Samantha Serody, Jonathan S. Murphy, William J. Munn, David H. Luznik, Leo Hill, Geoffrey MacDonald, Kelli K. P. Maillard, Ivan Koreth, John Cutler, Corey Soiffer, Robert J. Antin, Joseph H. Ritz, Jerome Panoskaltsis-Mortari, Angela Byrd, John C. Blazar, Bruce R. TI Ibrutinib can reverse established chronic graft-versus-host disease, which is dependent upon IL-2 inducible T-cell kinase (ITK) and Bruton's tyrosine kinase (BTK)-driven lymphocyte activation SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Dubovsky, Jason A.; Harrington, Bonnie K.; Zhong, Yiming; Yang, Carrie; Towns, William; Lehman, Amy; Johnson, Amy; Devine, Steven; Jaglowski, Samantha; Byrd, John C.] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA. [Flynn, Ryan; Du, Jing; Panoskaltsis-Mortari, Angela; Blazar, Bruce R.] Univ Minnesota, Minneapolis, MN USA. [Serody, Jonathan S.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Murphy, William J.] Univ Calif Davis, Ctr Canc, Sacramento, CA 95817 USA. [Murphy, William J.] Sch Med, Sacramento, CA USA. [Munn, David H.] Med Coll Georgia, Augusta, GA 30912 USA. [Luznik, Leo] Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA. [Hill, Geoffrey; MacDonald, Kelli K. P.] Queensland Inst Med Res, Berghofer Med Res Inst, Brisbane, Qld 4006, Australia. [Maillard, Ivan] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA. [Koreth, John; Cutler, Corey; Soiffer, Robert J.; Antin, Joseph H.; Ritz, Jerome] Dana Farber Canc Inst, Boston, MA 02115 USA. RI Jaglowski, Samantha/E-3304-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2591 DI 10.1158/1538-7445.AM2014-2591 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903334 ER PT J AU Dziadziuszko, R Karlovich, C Wen, W Sun, JM Chien, S Mann, E O'Donnell, P Angenendt, P Wakelee, H Horn, L Spigel, D Sequist, L Soria, JC Solomon, B Camidge, DR Goldman, J Gadgeel, S Raponi, M Allen, A Wu, L Park, K AF Dziadziuszko, Rafal Karlovich, Chris Wen, Wei Sun, Jong-Mu Chien, Sean Mann, Elaina O'Donnell, Patrick Angenendt, Philipp Wakelee, Heather Horn, Leora Spigel, David Sequist, Lecia Soria, Jean-Charles Solomon, Benjamin Camidge, D. Ross Goldman, Jonathan Gadgeel, Shirish Raponi, Mitch Allen, Andrew Wu, Lin Park, Keunchil TI Serial monitoring of EGFR mutations in plasma and evaluation of EGFR mutation status in matched tissue and plasma from NSCLC patients treated with CO-1686 SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Dziadziuszko, Rafal] Med Univ Gdansk, Gdansk, Poland. [Karlovich, Chris; Mann, Elaina; Raponi, Mitch; Allen, Andrew] Clovis Oncol Inc, San Francisco, CA USA. [Wen, Wei; Chien, Sean; O'Donnell, Patrick; Wu, Lin] Roche Mol Syst Inc, Pleasanton, CA USA. [Sun, Jong-Mu; Park, Keunchil] Sungkyunkwan Univ, Sch Med, Seoul, South Korea. [Angenendt, Philipp] Inost GMBH, Hamburg, Germany. [Wakelee, Heather] Stanford Univ, Stanford, CA 94305 USA. [Horn, Leora] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Spigel, David] Sarah Cannon Res Inst, Nashville, TN USA. [Sequist, Lecia] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Soria, Jean-Charles] Inst Gustave Roussy, Villejuif, France. [Solomon, Benjamin] Univ Melbourne, Melbourne, Vic, Australia. [Camidge, D. Ross] Univ Colorado, Denver, CO 80202 USA. [Goldman, Jonathan] Univ Calif Los Angeles, Santa Monica, CA USA. [Gadgeel, Shirish] Karmanos Canc Inst, Detroit, MI USA. NR 0 TC 0 Z9 1 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5587 DI 10.1158/1538-7445.AM2014-5587 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205001 ER PT J AU Efstathiou, E Deshpande, H George, D Joshua, AM Taplin, ME Griffin, TW Londhe, A Todd, M Molina, A AF Efstathiou, Eleni Deshpande, Hari George, Daniel Joshua, Anthony M. Taplin, Mary-Ellen Griffin, Thomas W. Londhe, Anil Todd, Mary Molina, Arturo TI An exploratory analysis of efficacy and safety of abiraterone acetate (AA) in black patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) without prior chemotherapy (ctx) SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Efstathiou, Eleni] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Deshpande, Hari] Yale Univ, Ctr Canc, New Haven, CT USA. [George, Daniel] Duke Univ, Med Ctr, Durham, NC USA. [Joshua, Anthony M.] Princess Margaret Canc Ctr, Toronto, ON, Canada. [Taplin, Mary-Ellen] Dana Farber Canc Inst, Boston, MA 02115 USA. [Griffin, Thomas W.] Janssen Res & Dev, Los Angeles, CA USA. [Londhe, Anil] Janssen Res & Dev, Horsham, PA USA. [Todd, Mary] Janssen Global Serv, Raritan, NJ USA. [Molina, Arturo] Janssen Res & Dev, Menlo Pk, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT313 DI 10.1158/1538-7445.AM2014-CT313 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205079 ER PT J AU Emerling, BM Hurov, JB Poulogiannis, G Choo-Wing, R Wulf, GM Shim, HS Lamia, KA Rameh, LE Yuan, X Bullock, A DeNicola, GM Song, JX Signoretti, S Cantley, LC AF Emerling, Brooke M. Hurov, Jonathan B. Poulogiannis, George Choo-Wing, Rayman Wulf, Gerburg M. Shim, Hye-Seok Lamia, Katja A. Rameh, Lucia E. Yuan, Xin Bullock, Andrea DeNicola, Gina M. Song, Jiaxi Signoretti, Sabina Cantley, Lewis C. TI Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res ID SUBSTRATE-SPECIFICITY; PTDINS5P; PATHWAY; CANCER C1 Weill Cornell Med Coll, New York, NY USA. Agios Pharmaceut, Cambridge, MA USA. Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. Scripps Res Inst, La Jolla, CA 92037 USA. Boston Univ, Sch Med, Boston, MA 02118 USA. Dana Farber Canc Inst, Boston, MA 02115 USA. RI Cantley, Lewis/D-1800-2014 OI Cantley, Lewis/0000-0002-1298-7653 NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA NG05 DI 10.1158/1538-7445.AM2014-NG05 PG 3 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205438 ER PT J AU Faber, AC Costa, C Dastur, A Benes, C Engelman, J AF Faber, Anthony C. Costa, Carlotta Dastur, Anahita Benes, Cyril Engelman, Jeffrey TI Assessment of ABT-263 activity across a comprehensive cancer cell line collection leads to a novel, potent combination therapy for small cell lung cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Faber, Anthony C.; Costa, Carlotta; Dastur, Anahita; Benes, Cyril; Engelman, Jeffrey] Massachusetts Gen Hosp Canc Ctr, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2933 DI 10.1158/1538-7445.AM2014-2933 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904203 ER PT J AU Fan, FJ Vallet, S Sattler, M Tonon, G Bashari, MH Bakiri, L Goldschmidt, H Wagner, EF Jaeger, D Podar, K AF Fan, Fengjuan Vallet, Sonia Sattler, Martin Tonon, Giovanni Bashari, Muhammad Hasan Bakiri, Latifa Goldschmidt, Hartmut Wagner, Erwin F. Jaeger, Dirk Podar, Klaus TI JunB/AP-1 controls MM cell proliferation, survival and drug resistance in the bone marrow microenvironment SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Fan, Fengjuan; Vallet, Sonia; Bashari, Muhammad Hasan; Goldschmidt, Hartmut; Jaeger, Dirk; Podar, Klaus] Heidelberg Univ, Heidelberg, Germany. [Sattler, Martin] Dana Farber Canc Inst, Boston, MA 02115 USA. [Tonon, Giovanni] Ist Sci San Raffaele, I-20132 Milan, Italy. [Bakiri, Latifa; Wagner, Erwin F.] Natl Canc Res Ctr CNIO, Madrid, Spain. RI Bashari, Muhammad Hasan/H-7079-2016 OI Bashari, Muhammad Hasan/0000-0001-7298-0317 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3383 DI 10.1158/1538-7445.AM2014-3383 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200383 ER PT J AU Fehringer, G Brenner, D Zhang, ZF Lee, YCA Matsuo, K Stucker, I Vineis, P Boffetta, P Brennan, P Landi, MT Morgenstern, H Harris, CC Lan, Q Hong, YC Siemiatycki, J McLaughlin, JR Lazarus, P Muscat, J Schwartz, AG Dios, JMB Ravina, AR Rennert, G Christiani, DC Tardon, A Marchand, LL Orlow, I Duell, EJ Andrew, AS Brenner, H Consonni, D Olsson, A Straif, K Hung, RJ AF Fehringer, Gordon Brenner, Darren Zhang, Zuo-Feng Lee, Yuan-Chin Amy Matsuo, Keitaro Stucker, Isabelle Vineis, Paolo Boffetta, Paolo Brennan, Paul Landi, Maria T. Morgenstern, Hal Harris, Curtis C. Lan, Qing Hong, Yun-Chul Siemiatycki, Jack McLaughlin, John R. Lazarus, Philip Muscat, Joshua Schwartz, Ann G. Barros Dios, Juan M. Ravina, Alberto R. Rennert, Gad Christiani, David C. Tardon, Adonina Marchand, Loic L. Orlow, Irene Duell, Eric J. Andrew, Angeline S. Brenner, Hermann Consonni, Dario Olsson, Ann Straif, Kurt Hung, Rayjean J. TI Alcohol and lung cancer risk: a pooled analysis using International Lung Cancer Consortium studies SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Fehringer, Gordon; Hung, Rayjean J.] Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada. [Brenner, Darren; Brennan, Paul; Olsson, Ann; Straif, Kurt] IARC, Lyon, France. [Zhang, Zuo-Feng] Univ Calif Los Angeles, Los Angeles, CA USA. [Lee, Yuan-Chin Amy] Univ Utah, Salt Lake City, UT USA. [Matsuo, Keitaro] Kyushu Univ, Fac Med Sci, Kyushu, Japan. [Stucker, Isabelle] INSERM, U170, Villejuif, France. [Vineis, Paolo] Univ London Imperial Coll Sci Technol & Med, London, England. [Boffetta, Paolo] Mt Sinai Sch Med, New York, NY USA. [Landi, Maria T.; Harris, Curtis C.; Lan, Qing] NCI, Bethesda, MD 20892 USA. [Morgenstern, Hal] Univ Michigan, Ann Arbor, MI 48109 USA. [Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Seoul, South Korea. [Siemiatycki, Jack] Univ Montreal Hosp Res Ctr CRCHUM, Montreal, PQ, Canada. [Siemiatycki, Jack] Sch Publ Hlth, Montreal, PQ, Canada. [McLaughlin, John R.] Publ Hlth Ontario, Toronto, ON, Canada. [Lazarus, Philip; Muscat, Joshua] Penn State Univ, Coll Med, Hershey, PA USA. [Schwartz, Ann G.] Wayne State Univ, Detroit, MI USA. [Barros Dios, Juan M.; Ravina, Alberto R.] Univ Santiago de Compostela, Santiago De Compostela, Spain. [Rennert, Gad] Technion Israel Inst Technol, Haifa, Israel. [Rennert, Gad] Natl Canc Control Ctr, Clalit Hlth Serv, Haifa, Israel. [Christiani, David C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Tardon, Adonina] Univ Oviedo, Univ Inst Oncol, Oviedo, Spain. [Marchand, Loic L.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Orlow, Irene] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Duell, Eric J.] Catalan Inst Oncol ICO, Barcelona, Spain. [Andrew, Angeline S.] Geisel Sch Med Dartmouth, Lebanon, PA USA. [Brenner, Hermann] German Canc Res Ctr, Heidelberg, Germany. [Consonni, Dario] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy. RI Consonni, Dario/K-7943-2016 OI Consonni, Dario/0000-0002-8935-3843 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1274 DI 10.1158/1538-7445.AM2014-1274 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901013 ER PT J AU Fei, T Chen, YW Du, Z Liu, XS Brown, M AF Fei, Teng Chen, Yiwen Du, Zhou Liu, Xiaole Shirley Brown, Myles TI Integrative analysis of functional long noncoding RNAs during prostate cancer progression SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Fei, Teng; Chen, Yiwen; Liu, Xiaole Shirley; Brown, Myles] Dana Farber Canc Inst, Boston, MA 02115 USA. [Du, Zhou] Tongji Univ, Shanghai 200092, Peoples R China. RI Fei, Teng/G-5324-2015 OI Fei, Teng/0000-0001-5707-0673 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5238 DI 10.1158/1538-7445.AM2014-5238 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204188 ER PT J AU Friboulet, L Li, NX Katayama, R Lee, CC Gainor, JF Crystal, AS Michellys, PY Awad, MM Yanagitani, N Kim, S Pferdekamper, A Li, J Kasibhatla, S Sun, F Sun, XY Hua, S McNamara, P Mahmood, S Lockerman, EL Fujita, N Nishio, M Harris, JL Shaw, AT Engelman, JA AF Friboulet, Luc Li, Nanxin Katayama, Ryohei Lee, Christian C. Gainor, Justin F. Crystal, Adam S. Michellys, Pierre-Yves Awad, Mark M. Yanagitani, Noriko Kim, Sungjoon Pferdekamper, AnneMarie Li, Jie Kasibhatla, Shailaja Sun, Frank Sun, Xiuying Hua, Su McNamara, Peter Mahmood, Sidra Lockerman, Elizabeth L. Fujita, Naoya Nishio, Makoto Harris, Jennifer L. Shaw, Alice T. Engelman, Jeffrey A. TI The ALK inhibitor LDK378 overcomes crizotinib resistance in non-small cell lung cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Friboulet, Luc; Gainor, Justin F.; Crystal, Adam S.; Awad, Mark M.; Mahmood, Sidra; Lockerman, Elizabeth L.; Shaw, Alice T.; Engelman, Jeffrey A.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Li, Nanxin; Lee, Christian C.; Michellys, Pierre-Yves; Kim, Sungjoon; Pferdekamper, AnneMarie; Li, Jie; Kasibhatla, Shailaja; Sun, Frank; Sun, Xiuying; Hua, Su; McNamara, Peter; Harris, Jennifer L.] Novartis Res Fdn, Genom Inst, San Diego, CA USA. [Katayama, Ryohei; Yanagitani, Noriko; Fujita, Naoya; Nishio, Makoto] Japanese Fdn Canc Res, Tokyo, Japan. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 957 DI 10.1158/1538-7445.AM2014-957 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905422 ER PT J AU Gameiro, SR Jammeh, ML Wattenberg, MM Tsang, KY Ferrone, S Hodge, JW AF Gameiro, Sofia R. Jammeh, Momodou L. Wattenberg, Max M. Tsang, Kwong Y. Ferrone, Soldano Hodge, James W. TI Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Gameiro, Sofia R.; Jammeh, Momodou L.; Wattenberg, Max M.; Tsang, Kwong Y.; Hodge, James W.] NCI CCR, Bethesda, MD USA. [Ferrone, Soldano] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 632 DI 10.1158/1538-7445.AM2014-632 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905094 ER PT J AU Gandhi, L Balmanoukian, A Hui, RN Hamid, O Rizvi, NA Leighl, N Gubens, M Goldman, JW Lubiniecki, GM Emancipator, K Dolled-Filhart, M Lunceford, JK Niewood, M Gergich, K Garon, EB AF Gandhi, Leena Balmanoukian, Ani Hui, Rina Hamid, Omid Rizvi, Naiyer A. Leighl, Natasha Gubens, Matthew Goldman, Jonathan W. Lubiniecki, Gregory M. Emancipator, Kenneth Dolled-Filhart, Marisa Lunceford, Jared K. Niewood, Michelle Gergich, Kevin Garon, Edward B. TI MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): Antitumor activity and association with tumor PD-L1 expression SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Gandhi, Leena] Dana Farber Canc Inst, Boston, MA 02115 USA. [Balmanoukian, Ani; Hamid, Omid] Angeles Clin & Res Inst, Los Angeles, CA USA. [Hui, Rina] Westmead Hosp, Sydney, NSW, Australia. [Rizvi, Naiyer A.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Leighl, Natasha] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada. [Gubens, Matthew] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Goldman, Jonathan W.] Univ Calif Los Angeles, Santa Monica, CA USA. [Lubiniecki, Gregory M.; Gergich, Kevin] Merck & Co Inc, N Wales, PA USA. [Emancipator, Kenneth; Dolled-Filhart, Marisa; Lunceford, Jared K.] Merck & Co Inc, Rahway, NJ 07065 USA. [Niewood, Michelle] Merck & Co Inc, Philadelphia, PA USA. [Garon, Edward B.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. NR 0 TC 13 Z9 14 U1 0 U2 6 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT105 DI 10.1158/1538-7445.AM2014-CT105 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205030 ER PT J AU Garcia, PL Gamblin, T Council, LN Christein, JD Arnoletti, JP Heslin, MJ Richardson, JH Qi, J Bradner, JE Yoon, KJ AF Garcia, Patrick L. Gamblin, Tracy Council, Leona N. Christein, John D. Arnoletti, J. Pablo Heslin, Martin J. Richardson, Joseph H. Qi, Jun Bradner, Jay E. Yoon, Karina J. TI JQ1 suppresses tumor growth in tumorgraft models of pancreatic ductal adenocarcinoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Garcia, Patrick L.; Gamblin, Tracy; Council, Leona N.; Christein, John D.; Heslin, Martin J.; Richardson, Joseph H.; Yoon, Karina J.] Univ Alabama Birmingham, Birmingham, AL USA. [Arnoletti, J. Pablo] Florida Hosp Canc Res, Orlando, FL USA. [Qi, Jun; Bradner, Jay E.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4612 DI 10.1158/1538-7445.AM2014-4612 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203086 ER PT J AU Gaykalova, DA Manola, J Ozawa, H Morton, K Bishop, J Considine, M Sharma, R Zhang, C Fertig, E Tan, M Hennessey, P Ahn, J Koch, W Khan, Z Chung, CH Ochs, MF Califano, JA AF Gaykalova, Daria A. Manola, Judi Ozawa, Hiroyuki Morton, Kathryn Bishop, Justin Considine, Michael Sharma, Rajni Zhang, Chi Fertig, Elana Tan, Marietta Hennessey, Patrick Ahn, Julie Koch, Wayne Khan, Zubair Chung, Christine H. Ochs, Michael F. Califano, Joseph A. TI Transcription factor signature of head and neck squamous cell carcinoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Gaykalova, Daria A.; Ozawa, Hiroyuki; Morton, Kathryn; Bishop, Justin; Considine, Michael; Sharma, Rajni; Fertig, Elana; Tan, Marietta; Hennessey, Patrick; Ahn, Julie; Koch, Wayne; Khan, Zubair; Chung, Christine H.; Califano, Joseph A.] Johns Hopkins Univ, Baltimore, MD USA. [Manola, Judi] Dana Farber Canc Inst, Boston, MA 02115 USA. [Zhang, Chi] Univ Virginia, Charlottesville, VA USA. [Ochs, Michael F.] Coll New Jersey, Ewing, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3409 DI 10.1158/1538-7445.AM2014-3409 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200409 ER PT J AU Ge, RB Wang, ZW Li, JJ Olumi, A AF Ge Rongbin Wang, Zongwei Li, Jijun Olumi, Aria TI Metformin represses cancer cells via alternate pathways in N-Cadherin wild-type and N-Cadherin-deficient cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Ge Rongbin; Wang, Zongwei; Li, Jijun; Olumi, Aria] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2765 DI 10.1158/1538-7445.AM2014-2765 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904022 ER PT J AU Ge, RB Wang, ZW Wu, CL Tabatabaei, S Olumi, A AF Ge Rongbin Wang, Zongwei Wu, Chin-Lee Tabatabaei, Shahin Olumi, Aria TI Dynamic expression of 5-alpha reductase 2 in aging prostate is regulated by DNA methyltransferase 1 SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Ge Rongbin; Wang, Zongwei; Wu, Chin-Lee; Tabatabaei, Shahin; Olumi, Aria] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2313 DI 10.1158/1538-7445.AM2014-2313 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903033 ER PT J AU Gkotzamanidou, M Shammas, M Terpos, E Raghavan, SC Anderson, KC Munshi, NC Dimopoulos, MA Souliotis, VL AF Gkotzamanidou, Maria Shammas, Masood Terpos, Evangelos Raghavan, Sathees C. Anderson, Kenneth C. Munshi, Nikhil C. Dimopoulos, Meletios-Athanasios Souliotis, Vassilis L. TI Deficient double strand breaks repair of bone marrow plasma cells correlates with better clinical outcome of multiple myeloma patients SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Gkotzamanidou, Maria; Shammas, Masood; Anderson, Kenneth C.; Munshi, Nikhil C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Terpos, Evangelos; Dimopoulos, Meletios-Athanasios] Univ Athens, Sch Med, Dept Clin Therapeut, Athens 11528, Greece. [Raghavan, Sathees C.] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India. [Souliotis, Vassilis L.] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4762 DI 10.1158/1538-7445.AM2014-4762 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203234 ER PT J AU Glavey, SV Naba, A Gambella, M Rocci, A Sacco, A Asara, J Palumbo, A Hynes, RO Roccaro, AM Ghobrial, IM AF Glavey, Siobhan V. Naba, Alexandra Gambella, Manuela Rocci, Alberto Sacco, Antonio Asara, John Palumbo, Antonio Hynes, Richard O. Roccaro, Aldo M. Ghobrial, Irene M. TI Proteomic characterization of the extracellular matrix in multiple myeloma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Glavey, Siobhan V.; Sacco, Antonio; Roccaro, Aldo M.; Ghobrial, Irene M.] DFCI, Boston, MA USA. [Naba, Alexandra; Hynes, Richard O.] MIT, Boston, MA USA. [Gambella, Manuela; Rocci, Alberto; Palumbo, Antonio] Univ Turin, I-10124 Turin, Italy. [Asara, John] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4855 DI 10.1158/1538-7445.AM2014-4855 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203319 ER PT J AU Gong, J Hutter, C Chang-Claude, J Newcomb, P Berndt, S Brenner, H Chan, AT Marchand, LL Harrison, T Lin, Y Slattery, ML White, E Potter, J Jiao, S Lemire, M Hsu, L Peters, U AF Gong, Jian Hutter, Carolyn Chang-Claude, Jenny Newcomb, Polly Berndt, Sonja Brenner, Hermann Chan, Andrew T. Marchand, Loic L. Harrison, Tabitha Lin, Yi Slattery, Martha L. White, Emily Potter, John Jiao, Shuo Lemire, Mathieu Hsu, Li Peters, Ulrike TI Genome-wide interaction analyses between genetic variants and alcohol consumption and risk of colorectal cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Gong, Jian; Newcomb, Polly; Harrison, Tabitha; Lin, Yi; White, Emily; Potter, John; Jiao, Shuo; Hsu, Li; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Hutter, Carolyn] NHGRI, Bethesda, MD 20892 USA. [Chang-Claude, Jenny; Brenner, Hermann] German Canc Res Ctr, Heidelberg, Germany. [Berndt, Sonja] NCI, Bethesda, MD 20892 USA. [Chan, Andrew T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Chan, Andrew T.] Harvard Univ, Sch Med, Boston, MA USA. [Marchand, Loic L.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Slattery, Martha L.] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA. [Lemire, Mathieu] Ontario Inst Canc Res, Toronto, ON, Canada. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2195 DI 10.1158/1538-7445.AM2014-2195 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902406 ER PT J AU GuhaThakurta, D Fan, LQ Vu, T Stewart, F Kantoff, P Small, E Higano, C Gardner, T Sheikh, N Trager, J AF GuhaThakurta, Debraj Fan, Li-Qun Tuyen Vu Stewart, Francis Kantoff, Philip Small, Eric Higano, Celeste Gardner, Thomas Sheikh, Nadeem Trager, James TI Sipuleucel-T-induced immune response against secondary cancer antigens is associated with improved overall survival SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res ID IMMUNOTHERAPY C1 [GuhaThakurta, Debraj; Fan, Li-Qun; Tuyen Vu; Stewart, Francis; Sheikh, Nadeem; Trager, James] Dendreon Corp, Seattle, WA USA. [Kantoff, Philip] Dana Farber Canc Inst, Boston, MA 02115 USA. [Small, Eric] UCSF Comprehens Canc Ctr, San Francisco, CA USA. [Higano, Celeste] Univ Washington, Sch Med, Seattle, WA USA. [Gardner, Thomas] Indiana Univ, Ctr Canc, Inianapolis, IN USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2542 DI 10.1158/1538-7445.AM2014-2542 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903280 ER PT J AU Gus-Brautbar, Y Casper, J Bielenberg, DR Cheng, J Schmidt, B Hammock, BD Zeldin, DC Kieran, MW Panigrahy, D AF Gus-Brautbar, Yael Casper, Jessica Bielenberg, Diane R. Cheng, Jennifer Schmidt, Birgitta Hammock, Bruce D. Zeldin, Darryl C. Kieran, Mark W. Panigrahy, Dipak TI The eicosanoid 20-HETE triggers Ras activation, pancreatic cancer growth and metastasis through inflammatory macrophage signaling SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Gus-Brautbar, Yael; Casper, Jessica; Panigrahy, Dipak] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Vasc Biol Res, Boston, MA 02215 USA. [Gus-Brautbar, Yael; Casper, Jessica; Panigrahy, Dipak] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pathol, Boston, MA 02215 USA. [Bielenberg, Diane R.] Harvard Univ, Sch Med, Boston Childrens Hosp, Vasc Biol Program, Boston, MA USA. [Cheng, Jennifer; Zeldin, Darryl C.] NIEHS, Lab Resp Biol, NIH, Res Triangle Pk, NC 27709 USA. [Schmidt, Birgitta] Harvard Univ, Sch Med, Dept Pathol, Boston Childrens Hosp, Boston, MA 02115 USA. [Hammock, Bruce D.] Univ Calif Davis, Dept Entomol, Davis, CA USA. [Hammock, Bruce D.] Univ Calif Davis, Canc Res Ctr, Davis, CA USA. [Kieran, Mark W.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Pediat Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4833 DI 10.1158/1538-7445.AM2014-4833 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203302 ER PT J AU Hahn, WC AF Hahn, William C. TI Functional genomics and cancer dependencies SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Hahn, William C.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA SY36-01 DI 10.1158/1538-7445.AM2014-SY36-01 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205477 ER PT J AU Han, Y Signorello, LB Strom, SS Kittles, RA Rybicki, BA Stanford, JL Goodman, PJ Berndt, SI Carpten, J Casey, G Chu, L Conti, DV Rand, KA Diver, R Hennis, AJ John, EM Kibel, AS Klein, EA Kolb, S Marchand, LL Leske, MC Murphy, AB Neslund-Dudas, C Park, JY Pettaway, CA Rebbeck, TR Gapstur, SM Zheng, SL Wu, SY Witte, JS Xu, JF Isaacs, WB Ingles, SA Hsing, AW Easton, DF Eeles, RA Schumacher, FR Chanock, SJ Nemesure, B Blot, WJ Stram, DO Henderson, BE Haiman, CA AF Han, Ying Signorello, Lisa B. Strom, Sara S. Kittles, Rick A. Rybicki, Benjamin A. Stanford, Janet L. Goodman, Phyllis J. Berndt, Sonja I. Carpten, John Casey, Graham Chu, Lisa Conti, David V. Rand, Kristin A. Diver, Ryan Hennis, Anselm J. John, Esther M. Kibel, Adam S. Klein, Eric A. Kolb, Suzanne Marchand, Loic L. Leske, M. Cristina Murphy, Adam B. Neslund-Dudas, Christine Park, Jong Y. Pettaway, Curtis A. Rebbeck, Timothy R. Gapstur, Susan M. Zheng, Siqun Lilly Wu, Suh-Yuh Witte, John S. Xu, Jianfeng Isaacs, William B. Ingles, Sue A. Hsing, Ann W. Easton, Douglas F. Eeles, Rosalind A. Schumacher, Fredrick R. Chanock, Stephen J. Nemesure, Barbara Blot, William J. Stram, Daniel O. Henderson, Brian E. Haiman, Christopher A. CA PRACTICAL Consortium ELLIPSE GAME-ON Consortium TI Generalizability of established prostate cancer risk variants in men of African ancestry SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Han, Ying; Casey, Graham; Conti, David V.; Rand, Kristin A.; Ingles, Sue A.; Schumacher, Fredrick R.; Stram, Daniel O.; Henderson, Brian E.; Haiman, Christopher A.] Univ So Calif, Los Angeles, CA USA. [Signorello, Lisa B.] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA. [Strom, Sara S.; Pettaway, Curtis A.] Univ Texas MD Anderson Canc Ctr, Houston, TX USA. [Kittles, Rick A.] Univ Illinois, Chicago, IL USA. [Rybicki, Benjamin A.; Neslund-Dudas, Christine] Henry Ford Hosp, Detroit, MI USA. [Stanford, Janet L.; Kolb, Suzanne] Fred Hutchinson Canc Res Ctr, Seattle, WA USA. [Goodman, Phyllis J.] SWOG Stat Ctr, Seattle, WA USA. [Berndt, Sonja I.; Chanock, Stephen J.] NIH, Bethesda, MD USA. [Carpten, John] Translat Genom Res Inst, Phoenix, AZ USA. [Chu, Lisa; John, Esther M.; Hsing, Ann W.] Canc Prevent Inst Calif, Fremont, CA USA. [Diver, Ryan; Gapstur, Susan M.] Amer Canc Soc, Atlanta, GA 30329 USA. [Hennis, Anselm J.; Leske, M. Cristina; Wu, Suh-Yuh; Nemesure, Barbara] SUNY Stony Brook, Stony Brook, NY USA. [Kibel, Adam S.] Dana Farber Canc Inst, Boston, MA USA. [Klein, Eric A.] Cleveland Clin, Cleveland, OH USA. [Marchand, Loic L.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Murphy, Adam B.] Northwestern Univ, Evanston, IL 60208 USA. [Park, Jong Y.] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. [Rebbeck, Timothy R.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Rebbeck, Timothy R.] Abramson Canc Ctr, Philadelphia, PA USA. [Zheng, Siqun Lilly; Xu, Jianfeng] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA. [Witte, John S.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Isaacs, William B.] Johns Hopkins Hosp & Med Inst, Baltimore, MD USA. [Easton, Douglas F.] Univ Cambridge, Cambridge CB2 1TN, England. [Blot, William J.] Vanderbilt Univ, Sch Med, Nashville, TN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5066 DI 10.1158/1538-7445.AM2014-5066 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204021 ER PT J AU Hata, AN Archibald, HL Gomez-Caraballo, MD DeBussche, LR Sidhu, S Watters, J Engelman, JA AF Hata, Aaron N. Archibald, Hannah L. Gomez-Caraballo, Maria D. DeBussche, Laurent R. Sidhu, Sukhvinder Watters, James Engelman, Jeffrey A. TI Combined inhibition of MDM2 and MEK for KRAS mutant non-small cell lung cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Hata, Aaron N.; Archibald, Hannah L.; Gomez-Caraballo, Maria D.; Engelman, Jeffrey A.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [DeBussche, Laurent R.; Sidhu, Sukhvinder] Sanofi Oncol, Vitry Sur Seine, France. [Watters, James] Sanofi Oncol, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 741 DI 10.1158/1538-7445.AM2014-741 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905201 ER PT J AU Helming, K Wang, XF Wilson, B Vazquez, F Haswell, J Manchester, H Kim, Y Kryukov, GV Ghandi, M Aguirre, AJ Jagani, Z Wang, Z Garraway, L Hahn, W Roberts, C AF Helming, Katherine Wang, Xiaofeng Wilson, Boris Vazquez, Francisca Haswell, Jeffrey Manchester, Haley Kim, Youngha Kryukov, Gregory V. Ghandi, Mahmoud Aguirre, Andrew J. Jagani, Zainab Wang, Zhong Garraway, Levi Hahn, William Roberts, Charles TI ARID1B is a specific vulnerability in ARID1A-mutant cancers SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Helming, Katherine; Wang, Xiaofeng; Wilson, Boris; Haswell, Jeffrey; Manchester, Haley; Kim, Youngha; Garraway, Levi; Hahn, William; Roberts, Charles] Dana Farber Canc Inst, Boston, MA 02115 USA. [Vazquez, Francisca; Kryukov, Gregory V.; Ghandi, Mahmoud; Aguirre, Andrew J.] Broad Inst, Cambridge, MA USA. [Jagani, Zainab] Novartis, Cambridge, MA USA. [Wang, Zhong] Univ Michigan, Ann Arbor, MI 48109 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-126 DI 10.1158/1538-7445.AM2014-LB-126 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205159 ER PT J AU Hibino, Y Takaaki, S Minami, Y Janne, PA Ohsaki, Y AF Hibino, Yukiko Takaaki, Sasaki Minami, Yoshinori Janne, Pasi A. Ohsaki, Yoshinobu TI Intrinsic and acquired resistance mechanisms of alectinib in ALK rearranged cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Hibino, Yukiko; Takaaki, Sasaki; Minami, Yoshinori; Ohsaki, Yoshinobu] Asahikawa Med Univ, Asahikawa, Hokkaido, Japan. [Janne, Pasi A.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3720 DI 10.1158/1538-7445.AM2014-3720 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201211 ER PT J AU Hong, AL Riester, M Schinzel, AC Schlauch, A Adam, RM Kwiatkowski, DJ Rosenberg, JE Hahn, WC AF Hong, Andrew L. Riester, Markus Schinzel, Anna C. Schlauch, Amy Adam, Rosalyn M. Kwiatkowski, David J. Rosenberg, Jonathan E. Hahn, William C. TI ARHGAP30 and DEDD as potential genomic drivers of invasive urothelial carcinomas SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Hong, Andrew L.; Hahn, William C.] Boston Childrens Hosp, Dana Farber Canc Inst, Broad Inst, Boston, MA USA. [Hong, Andrew L.; Hahn, William C.] Boston Childrens Hosp, Dana Farber Canc Inst, Broad Inst, Cambridge, MA USA. [Riester, Markus; Schinzel, Anna C.; Schlauch, Amy] Dana Farber Canc Inst, Boston, MA 02115 USA. [Adam, Rosalyn M.] Boston Childrens Hosp, Boston, MA USA. [Kwiatkowski, David J.] Brigham & Womens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. [Rosenberg, Jonathan E.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3433 DI 10.1158/1538-7445.AM2014-3433 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200432 ER PT J AU Hsu, L Jeon, J Brenner, H Berndt, S Chan, AT Chang-Claude, J Gruber, SB Harrison, T Hoffmeister, M Newcomb, P Potter, J Schumacher, F Slattery, M Thomas, D White, E Zheng, YY Peters, U AF Hsu, Li Jeon, Jihyoun Brenner, Hermann Berndt, Sonja Chan, Andrew T. Chang-Claude, Jenny Gruber, Stephen B. Harrison, Tabitha Hoffmeister, Michael Newcomb, Polly Potter, John Schumacher, Fredrick Slattery, Martha Thomas, Duncan White, Emily Zheng, Yingye Peters, Ulrike CA Colorectal Transdisciplinary Study Genetics Epidemiology Colorectal TI Assessing colorectal cancer risk using known genetic susceptibility variants and family history accounting for endoscopy SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Hsu, Li; Jeon, Jihyoun; Harrison, Tabitha; Newcomb, Polly; Potter, John; White, Emily; Zheng, Yingye; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA 98104 USA. [Brenner, Hermann; Hoffmeister, Michael] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany. [Berndt, Sonja] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Chan, Andrew T.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA. [Chan, Andrew T.] Harvard Univ, Sch Med, Boston, MA USA. [Chan, Andrew T.] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA. [Chang-Claude, Jenny] German Canc Res Ctr, Dept Canc Epidemiol, Heidelberg, Germany. [Gruber, Stephen B.] Univ So Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA. [Potter, John] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand. [Schumacher, Fredrick; Thomas, Duncan] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Slattery, Martha] Univ Utah, Dept Internal Med, Hlth Sci Ctr, Salt Lake City, UT 84112 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2921 DI 10.1158/1538-7445.AM2014-2921 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904190 ER PT J AU Iams, WT Johnson, DB Flavin, M Panageas, K Ayers, GD Zhao, ZG Iafrate, AJ Sullivan, RJ Carvajal, RD Sosman, JA Lovly, CM AF Iams, Wade T. Johnson, Douglas B. Flavin, Marisa Panageas, Katherine Ayers, Gregory D. Zhao, Zhiguo Iafrate, Anthony John Sullivan, Ryan J. Carvajal, Richard D. Sosman, Jeffrey A. Lovly, Christine M. TI NRAS mutation as a predictor of response to immune-based therapies in patients with metastatic melanoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Iams, Wade T.; Johnson, Douglas B.; Ayers, Gregory D.; Zhao, Zhiguo; Sosman, Jeffrey A.; Lovly, Christine M.] Vanderbilt Univ Sch Med, Nashville, TN USA. [Flavin, Marisa; Panageas, Katherine; Carvajal, Richard D.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Iafrate, Anthony John; Sullivan, Ryan J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2942 DI 10.1158/1538-7445.AM2014-2942 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904213 ER PT J AU Imielinski, M Du, C Meyerson, M AF Imielinski, Marcin Du, Charles Meyerson, Matthew TI Identifying somatic mutation hotspots across protein family alignments SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Imielinski, Marcin] Broad Inst MIT & Harvard, Cambridge, MA USA. [Du, Charles; Meyerson, Matthew] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4263 DI 10.1158/1538-7445.AM2014-4263 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910202239 ER PT J AU Jones, GC Mitchell, JB Johnson, BE Camphausen, K Glatstein, E Simone, CB AF Jones, Guy C. Mitchell, James B. Johnson, Bruce E. Camphausen, Kevin Glatstein, Eli Simone, Charles B. TI Phase II study of low-dose rate thoracic radiotherapy for treatment of intrathoracic relapsed or progressive small cell lung cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Jones, Guy C.; Mitchell, James B.; Camphausen, Kevin] Natl Canc Inst, Bethesda, MD USA. [Johnson, Bruce E.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Glatstein, Eli; Simone, Charles B.] Univ Penn, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT343 DI 10.1158/1538-7445.AM2014-CT343 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205107 ER PT J AU Katiyar, SK Singh, T Vaid, M AF Katiyar, Santosh K. Singh, Tripti Vaid, Mudit TI Dietary grape seed proanthocyanidins inhibit UV-induced immune suppression by targeting the development of regulatory T cells in mice SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Katiyar, Santosh K.; Singh, Tripti; Vaid, Mudit] Univ Alabama Birmingham, Birmingham, AL USA. [Katiyar, Santosh K.] Birmingham VA Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1239 DI 10.1158/1538-7445.AM2014-1239 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900477 ER PT J AU Kaufman, CK Mosimann, C White, RM Matos, D Zon, LI AF Kaufman, Charles K. Mosimann, Christian White, Richard M. Matos, Dominic Zon, Leonard I. TI Identifying key molecular events at the onset of melanoma using a neural crest stem cell marker SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Kaufman, Charles K.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Mosimann, Christian] Univ Zurich, Zurich, Switzerland. [White, Richard M.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Matos, Dominic; Zon, Leonard I.] Boston Childrens Hosp, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2045 DI 10.1158/1538-7445.AM2014-2045 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902257 ER PT J AU Kim, H Zheng, SY Amini, SS Virk, SM Mikkelsen, T Brat, DJ Grimsby, J Sougnez, C Sloan, AE Cohen, ML Van Meir, EG Scarpace, L Laird, PW Weinstein, JN Lander, E Gabriel, S Getz, G Meyerson, M Chin, L Barnholtz-Sloan, JS Verhaak, RGW AF Kim, Hoon Zheng, Siyuan Amini, Seyed S. Virk, Selene M. Mikkelsen, Tom Brat, Daniel J. Grimsby, Jonna Sougnez, Carrie Sloan, Andrew E. Cohen, Mark L. Van Meir, Erwin G. Scarpace, Lisa Laird, Peter W. Weinstein, John N. Lander, Eric Gabriel, Stacey Getz, Gad Meyerson, Matthew Chin, Lynda Barnholtz-Sloan, Jill S. Verhaak, Roel G. W. CA Canc Genome Res Network TI Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Kim, Hoon; Zheng, Siyuan; Amini, Seyed S.; Weinstein, John N.; Chin, Lynda; Verhaak, Roel G. W.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Virk, Selene M.; Sloan, Andrew E.; Cohen, Mark L.; Barnholtz-Sloan, Jill S.] Case Comprehens Canc Ctr, Cleveland, OH USA. [Mikkelsen, Tom; Scarpace, Lisa] Henry Ford Hosp, Detroit, MI 48202 USA. [Brat, Daniel J.; Van Meir, Erwin G.] Emory Univ, Sch Med, Atlanta, GA USA. [Grimsby, Jonna; Sougnez, Carrie; Lander, Eric; Gabriel, Stacey; Getz, Gad] Broad Inst MIT & Harvard, Cambridge, MA USA. [Laird, Peter W.] Univ So Calif, Los Angeles, CA USA. [Meyerson, Matthew] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 984 DI 10.1158/1538-7445.AM2014-984 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905451 ER PT J AU Kim, Y Hammerman, PS Kim, J Getz, G Meyerson, M Park, K AF Kim, Youngwook Hammerman, Peter S. Kim, Jaegil Getz, Gad Meyerson, Matthew Park, Keunchil TI Integrative and comparative genomic analysis of East-Asian lung squamous cell carcinomas SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Kim, Youngwook; Park, Keunchil] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea. [Hammerman, Peter S.; Kim, Jaegil; Getz, Gad] Broad Inst, Cambridge, MA USA. [Meyerson, Matthew] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1526 DI 10.1158/1538-7445.AM2014-1526 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901253 ER PT J AU Knoechel, B Roderick, J Williamson, K Zhu, J Lohr, J Cotton, M Gillespie, S Fernandez, D Ku, MC Wang, HF Piccioni, F Silver, S Jain, M Pearson, D Kluk, M Ott, C Greiner, D Brehm, M Shultz, L Gutierrez, A Stegmaier, K Harris, M Silverman, L Sallan, S Kung, A Root, D Bradner, J Aster, J Kelliher, M Bernstein, B AF Knoechel, Birgit Roderick, Justine Williamson, Kaylyn Zhu, Jiang Lohr, Jens Cotton, Matthew Gillespie, Shawn Fernandez, Daniel Ku, Manching Wang, Hongfang Piccioni, Federica Silver, Serena Jain, Mohit Pearson, Daniel Kluk, Michael Ott, Christopher Greiner, Dale Brehm, Michael Shultz, Leonard Gutierrez, Alejandro Stegmaier, Kimberly Harris, Marian Silverman, Lewis Sallan, Stephen Kung, Andrew Root, David Bradner, James Aster, Jon Kelliher, Michelle Bernstein, Bradley TI Epigenetic resistance to Notch inhibition in T cell acute lymphoblastic leukemia SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Knoechel, Birgit; Lohr, Jens; Ott, Christopher; Gutierrez, Alejandro; Stegmaier, Kimberly; Harris, Marian; Silverman, Lewis; Sallan, Stephen; Bradner, James] Dana Farber Canc Inst, Boston, MA 02115 USA. [Roderick, Justine; Greiner, Dale; Brehm, Michael; Kelliher, Michelle] Univ Massachusetts, Worcester, MA 01605 USA. [Williamson, Kaylyn; Zhu, Jiang; Cotton, Matthew; Gillespie, Shawn; Ku, Manching; Bernstein, Bradley] MGH, Boston, MA USA. [Fernandez, Daniel] Harvard Univ, Cambridge, MA 02138 USA. [Wang, Hongfang; Kluk, Michael; Aster, Jon] BWH, Boston, MA USA. [Piccioni, Federica; Silver, Serena; Jain, Mohit; Root, David] Broad Inst, Cambridge, MA USA. [Pearson, Daniel] Harvard Univ, Sch Med, Boston, MA USA. [Shultz, Leonard] Jackson Lab, Bar Harbor, ME 04609 USA. [Kung, Andrew] Columbia Univ, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4782 DI 10.1158/1538-7445.AM2014-4782 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203252 ER PT J AU Kocarnik, JM Passarelli, MN Phipps, AI Chan, AT Gala, M Joshi, A Campbell, PT Slattery, ML Potter, J White, E Berndt, S Peters, U Newcomb, PA AF Kocarnik, Jonathan M. Passarelli, Michael N. Phipps, Amanda I. Chan, Andrew T. Gala, Manish Joshi, Amit Campbell, Peter T. Slattery, Martha L. Potter, John White, Emily Berndt, Sonja Peters, Ulrike Newcomb, Polly A. TI Colorectal cancer survival is not associated with genetic variants related to risk of other cancers: The GECCO study SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Kocarnik, Jonathan M.; Passarelli, Michael N.; Phipps, Amanda I.; Potter, John; White, Emily; Peters, Ulrike; Newcomb, Polly A.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Chan, Andrew T.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Gala, Manish] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Joshi, Amit] Harvard Univ, Boston, MA 02115 USA. [Campbell, Peter T.] Amer Canc Soc, Atlanta, GA 30329 USA. [Slattery, Martha L.] Univ Utah Hlth Sci Ctr, Salt Lake City, UT USA. [Berndt, Sonja] NCI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2187 DI 10.1158/1538-7445.AM2014-2187 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902398 ER PT J AU Krepler, C Sproesser, K Brafford, P Xiao, M Beqiri, M Xu, W Nathanson, K Wargo, J Flaherty, K Morton, DL Hoon, DS Ryan, R Guarino, M Petrelli, NJ Elder, D Xu, XW Karakousis, G Schuchter, L Herlyn, M AF Krepler, Clemens Sproesser, Katrin Brafford, Patricia Xiao, Min Beqiri, Marilda Xu, Wei Nathanson, Katherine Wargo, Jennifer Flaherty, Keith Morton, Donald L. Hoon, Dave S. Ryan, Randall Guarino, Michael Petrelli, Nicholas J. Elder, David Xu, Xiawei Karakousis, Giorgos Schuchter, Lynn Herlyn, Meenhard TI Patient derived xenograft (PDX) of human melanoma to predict clinical responses SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Krepler, Clemens; Sproesser, Katrin; Brafford, Patricia; Xiao, Min; Beqiri, Marilda; Herlyn, Meenhard] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA. [Xu, Wei; Nathanson, Katherine; Elder, David; Xu, Xiawei; Karakousis, Giorgos; Schuchter, Lynn] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Wargo, Jennifer] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Flaherty, Keith] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Morton, Donald L.; Hoon, Dave S.] John Wayne Canc Inst, Santa Monica, CA USA. [Ryan, Randall; Guarino, Michael; Petrelli, Nicholas J.] Helen F Graham Canc Ctr, Newark, DE USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1182 DI 10.1158/1538-7445.AM2014-1182 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900420 ER PT J AU Kumar, R Belz, J Markovic, S Niedre, M Ngwa, W Korideck, H Cormack, R Nguyen, P D'Amico, A Makrigiorgos, M Sridhar, S AF Kumar, Rajiv Belz, Jodi Markovic, Stacey Niedre, Mark Ngwa, Wilfred Korideck, Houari Cormack, Robert Nguyen, Paul D'Amico, Anthony Makrigiorgos, Mike Sridhar, Srinivas TI Smart brachytherapy spacers eluting nanoencapsulated radiosensitizers for chemo-radiation therapy SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Kumar, Rajiv; Belz, Jodi; Markovic, Stacey; Niedre, Mark; Sridhar, Srinivas] Northeastern Univ, Boston, MA 02115 USA. [Ngwa, Wilfred; Korideck, Houari; Cormack, Robert; Nguyen, Paul; D'Amico, Anthony; Makrigiorgos, Mike] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4917 DI 10.1158/1538-7445.AM2014-4917 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203380 ER PT J AU Lamoureux, F Baud'Huin, M Calleja, LR Jacques, C Redini, F Bradner, JE Heymann, D Ory, B AF Lamoureux, Francois Baud'Huin, Marc Calleja, Lidia Rodriguez Jacques, Camille Redini, Francoise Bradner, James E. Heymann, Dominique Ory, Benjamin TI Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Lamoureux, Francois; Baud'Huin, Marc; Calleja, Lidia Rodriguez; Jacques, Camille; Redini, Francoise; Heymann, Dominique; Ory, Benjamin] INSERM UMR957, Nantes, France. [Bradner, James E.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. RI REDINI, Francoise/K-7981-2015 NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-142 DI 10.1158/1538-7445.AM2014-LB-142 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205175 ER PT J AU Lane, AA Chapuy, B Lin, CY Tivey, T Li, HB Townsend, E van Bodegom, D Day, TA Wu, SC Liu, HY Yoda, A Alexe, G Schinzel, A Sullivan, TJ Malinge, S Taylor, J Stegmaier, K Jaffe, J Bustin, M te Kronnie, G Izraeli, S Harris, M Stevenson, K Neuberg, D Silverman, LB Sallan, SE Bradner, JE Hahn, WC Crispino, JD Pellman, D Weinstock, DM AF Lane, Andrew A. Chapuy, Bjoern Lin, Charles Y. Tivey, Trevor Li, Hubo Townsend, Elizabeth van Bodegom, Diederik Day, Tovah A. Wu, Shuo-Chieh Liu, Huiyun Yoda, Akinori Alexe, Gabriela Schinzel, Anna Sullivan, Timothy J. Malinge, Sebastien Taylor, Jordan Stegmaier, Kimberly Jaffe, Jacob Bustin, Michael te Kronnie, Geertruy Izraeli, Shai Harris, Marian Stevenson, Kristen Neuberg, Donna Silverman, Lewis B. Sallan, Steven E. Bradner, James E. Hahn, William C. Crispino, John D. Pellman, David Weinstock, David M. TI Triplication of HMGN1 promotes B cell acute lymphoblastic leukemia (B-ALL) through suppression of H3K27me3 SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Lane, Andrew A.; Chapuy, Bjoern; Lin, Charles Y.; Tivey, Trevor; Li, Hubo; Townsend, Elizabeth; van Bodegom, Diederik; Day, Tovah A.; Wu, Shuo-Chieh; Liu, Huiyun; Yoda, Akinori; Alexe, Gabriela; Schinzel, Anna; Sullivan, Timothy J.; Stegmaier, Kimberly; Stevenson, Kristen; Neuberg, Donna; Silverman, Lewis B.; Sallan, Steven E.; Bradner, James E.; Hahn, William C.; Pellman, David; Weinstock, David M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Malinge, Sebastien] Inst Gustave Roussy, INSERM, U985, F-94805 Villejuif, France. [Taylor, Jordan; Jaffe, Jacob] Broad Inst, Cambridge, MA USA. [Bustin, Michael] NCI, Bethesda, MD 20892 USA. [te Kronnie, Geertruy] Univ Padua, Padua, Italy. [Izraeli, Shai] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel. [Izraeli, Shai] Tel Aviv Univ, Tel Hashomer, Israel. [Harris, Marian] Childrens Hosp, Boston, MA 02115 USA. [Crispino, John D.] Northwestern Univ, Chicago, IL 60611 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 433 DI 10.1158/1538-7445.AM2014-433 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904398 ER PT J AU Lee, DHT Qi, J Bradner, J Said, J Doan, N Forscher, C Koeffler, HP AF Lee, Dhong Hyun Tony Qi, Jun Bradner, James Said, Jonathan Doan, Ngan Forscher, Charles Koeffler, H. Phillip TI Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Lee, Dhong Hyun Tony; Forscher, Charles; Koeffler, H. Phillip] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Qi, Jun; Bradner, James] Dana Farber Canc Inst, Boston, MA 02115 USA. [Said, Jonathan; Doan, Ngan] Univ Calif Los Angeles, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1689 DI 10.1158/1538-7445.AM2014-1689 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901411 ER PT J AU Leshchiner, E Bellairs, J Bird, GH Opoku-Nsiah, K Godes, M Walensky, LD AF Leshchiner, Elizaveta Bellairs, Joseph Bird, Gregory H. Opoku-Nsiah, Kwadwo Godes, Marina Walensky, Lored D. TI Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Leshchiner, Elizaveta; Bellairs, Joseph; Bird, Gregory H.; Opoku-Nsiah, Kwadwo; Godes, Marina; Walensky, Lored D.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2597 DI 10.1158/1538-7445.AM2014-2597 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903340 ER PT J AU Leung, CS Yeung, TL Yip, KP Wong, KK Sood, AK Birrer, MJ Mok, SC AF Leung, Cecilia S. Yeung, Tsz-Lun Yip, Kay-Pong Wong, Kwong-Kwok Sood, Anil K. Birrer, Michael J. Mok, Samuel C. TI CAF-derived MFAP5 promotes ovarian tumor angiogenesis through calcium dependent LPP signaling pathway SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Leung, Cecilia S.; Yeung, Tsz-Lun; Wong, Kwong-Kwok; Sood, Anil K.; Mok, Samuel C.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Yip, Kay-Pong] Univ S Florida, Tampa, FL USA. [Birrer, Michael J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1029 DI 10.1158/1538-7445.AM2014-1029 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900257 ER PT J AU Lin, L Vega, M Jones, RT Ziaugra, L Dolcen, DN Sunkavalli, A Schubert, L Lepine, JR Thorner, AR Ducar, MD Hahn, WC Meyerson, ML MacConaill, LE Van Hummelen, P AF Lin, Ling Vega, Mikenah Jones, Robert T. Ziaugra, Liuda Dolcen, Deniz N. Sunkavalli, Ashwini Schubert, Laura Lepine, Jack R. Thorner, Aaron R. Ducar, Matthew D. Hahn, William C. Meyerson, Matthew L. MacConaill, Laura E. Van Hummelen, Paul TI Improved FFPE DNA extraction for next generation sequencing using adaptive focused acoustics technology SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Lin, Ling; Vega, Mikenah; Jones, Robert T.; Ziaugra, Liuda; Dolcen, Deniz N.; Sunkavalli, Ashwini; Schubert, Laura; Lepine, Jack R.; Thorner, Aaron R.; Ducar, Matthew D.; Hahn, William C.; Meyerson, Matthew L.; MacConaill, Laura E.; Van Hummelen, Paul] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4286 DI 10.1158/1538-7445.AM2014-4286 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910202262 ER PT J AU Liu, G Sprenger, C Wu, PJ Sun, SH Uo, T Haugk, K Epilepsia, KS Plymate, S AF Liu, Gang Sprenger, Cynthia Wu, Pin-Jou Sun, Shihua Uo, Takuma Haugk, Kathleen Epilepsia, Kathryn Soriano Plymate, Stephen TI Phospho-MED1 mediates the transcriptional regulation of AR splice variants in castration-resistant prostate cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Liu, Gang; Sprenger, Cynthia; Wu, Pin-Jou; Sun, Shihua; Uo, Takuma; Epilepsia, Kathryn Soriano; Plymate, Stephen] Univ Washington, Seattle, WA 98195 USA. [Haugk, Kathleen] Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2324 DI 10.1158/1538-7445.AM2014-2324 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903045 ER PT J AU Luo, F Garraway, L AF Luo, Flora Garraway, Levi TI Functional characterization of ARID2 in melanoma and melanocytes SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 Harvard Univ, Dana Farber Canc Inst, Boston, MA 02115 USA. Broad Inst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3431 DI 10.1158/1538-7445.AM2014-3431 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200430 ER PT J AU Luo, X Mitra, D Sullivan, RJ Wittner, BS Kimura, AM Pan, SW Hoang, MP Brannigan, BW Lawrence, DP Flaherty, KT Sequist, LV Stott, SL Ting, DT Ramaswamy, S Toner, M Fisher, DE Maheswaran, S Haber, DA AF Luo, Xi Mitra, Devarati Sullivan, Ryan J. Wittner, Ben S. Kimura, Anya M. Pan, Shiwei Hoang, Mai P. Brannigan, Brian W. Lawrence, Donald P. Flaherty, Keith T. Sequist, Lecia V. Stott, Shannon L. Ting, David T. Ramaswamy, Sridhar Toner, Mehmet Fisher, David E. Maheswaran, Shyamala Haber, Daniel A. TI Isolation and molecular characterization of circulating melanoma cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Luo, Xi; Wittner, Ben S.; Kimura, Anya M.; Pan, Shiwei; Brannigan, Brian W.; Ting, David T.; Ramaswamy, Sridhar; Maheswaran, Shyamala; Haber, Daniel A.] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA USA. [Mitra, Devarati; Fisher, David E.] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA USA. [Sullivan, Ryan J.; Lawrence, Donald P.; Flaherty, Keith T.; Sequist, Lecia V.] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Hoang, Mai P.] Massachusetts Gen Hosp, Dept Pathol, Charlestown, MA USA. [Stott, Shannon L.; Toner, Mehmet] Massachusetts Gen Hosp, Ctr Engn Med, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4832 DI 10.1158/1538-7445.AM2014-4832 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203301 ER PT J AU Marquard, AM Eklund, AC Wang, ZGC Richardson, AL Szallasi, Z Birkbak, NJ AF Marquard, Andrea M. Eklund, Aron C. Wang, Zhigang C. Richardson, Andrea L. Szallasi, Zoltan Birkbak, Nicolai J. TI A pan-cancer analysis of inferred homologous recombination deficiency identifies potential platinum benefit in novel subtypes SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Marquard, Andrea M.; Eklund, Aron C.; Szallasi, Zoltan; Birkbak, Nicolai J.] Tech Univ Denmark, Ctr Biol Sequence Anal, Lyngby, Denmark. [Wang, Zhigang C.] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. [Richardson, Andrea L.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. OI Marquard, Andrea/0000-0003-2928-6017 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2822 DI 10.1158/1538-7445.AM2014-2822 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904082 ER PT J AU Merrick, DT Edwards, MG Franklin, WA Sugita, M Friedman, M Miller, YE Dwyer-Nield, L Tennis, M Choo, K Hickey, G Adriaan, V Heasley, L Bunn, PA Geraci, M Keith, RL Nemenoff, R AF Merrick, Daniel T. Edwards, Michael G. Franklin, Wilbur A. Sugita, Michio Friedman, Micah Miller, York E. Dwyer-Nield, Lori Tennis, Meredith Choo, Kevin Hickey, Greg Adriaan, van Bokhoven Heasley, Lynn Bunn, Paul A. Geraci, Mark Keith, Robert L. Nemenoff, Raphael TI Gene expression analysis of persistent and regressive bronchial dysplasia identifies polo-like kinase 1 (PLK1) and epoxide hydrolase 3 (EPHX3) as potential mediators of malignant progression SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Merrick, Daniel T.; Friedman, Micah; Miller, York E.; Dwyer-Nield, Lori; Choo, Kevin; Keith, Robert L.] Denver VAMC, Denver, CO USA. [Edwards, Michael G.; Franklin, Wilbur A.; Sugita, Michio; Tennis, Meredith; Hickey, Greg; Adriaan, van Bokhoven; Heasley, Lynn; Bunn, Paul A.; Geraci, Mark; Nemenoff, Raphael] Univ Colorado, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 231 DI 10.1158/1538-7445.AM2014-231 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903029 ER PT J AU Mirkheshti, N Song, C Chatterjee, B AF Mirkheshti, Nooshin Song, Chung Chatterjee, Bandana TI The antibiotic salinomycin cotargets two pivotal pathways in prostate cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Mirkheshti, Nooshin; Song, Chung] UT Hlth Sci Ctr San Antonio, San Antonio, TX USA. [Chatterjee, Bandana] South Texas Vet Hlth Care Syst, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3312 DI 10.1158/1538-7445.AM2014-3312 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200312 ER PT J AU Mohapatra, G He, L Guo, LK Vathipadiekal, V Sergent, P Growdon, W Rueda, B Engler, D Orsulic, S Birrer, M AF Mohapatra, Gayatry He, Lei Guo, Lankai Vathipadiekal, Vinod Sergent, Petra Growdon, Whitfield Rueda, Bo Engler, David Orsulic, Sandra Birrer, Michael TI Identification of LMX1B as a novel oncogene in human ovarian cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Mohapatra, Gayatry; He, Lei; Guo, Lankai; Vathipadiekal, Vinod; Sergent, Petra; Growdon, Whitfield; Rueda, Bo; Birrer, Michael] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Engler, David] Brigham Young Univ, Provo, UT 84602 USA. [Orsulic, Sandra] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1534 DI 10.1158/1538-7445.AM2014-1534 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901260 ER PT J AU Montero, J Sarosiek, KA DeAngelo, JD Piao, HY Horowitz, N Berkowitz, R Matulonis, U Drapkin, R Letai, A AF Montero, Joan Sarosiek, Kris A. DeAngelo, Joe D. Piao, Huiying Horowitz, Neil Berkowitz, Ross Matulonis, Ursula Drapkin, Ronny Letai, Anthony TI Hitting the target: Dynamic BH3 profiling, a novel functional assay to predict chemotherapy response SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Montero, Joan; Sarosiek, Kris A.; DeAngelo, Joe D.; Piao, Huiying; Horowitz, Neil; Berkowitz, Ross; Matulonis, Ursula; Drapkin, Ronny; Letai, Anthony] Dana Farber Canc Inst, Boston, MA 02115 USA. RI Drapkin, Ronny/E-9944-2016 OI Drapkin, Ronny/0000-0002-6912-6977 NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2837 DI 10.1158/1538-7445.AM2014-2837 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904098 ER PT J AU Moore, N Pukma, S Gray, N George, R AF Moore, Nathan Pukma, Srunphut Gray, Nathanael George, Rani TI A high-throughput chemical screen identifies synergistic activity between neurotransmitter receptor inhibitors and crizotinib in ALK-mutated neuroblastoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Moore, Nathan; Pukma, Srunphut; Gray, Nathanael; George, Rani] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 790 DI 10.1158/1538-7445.AM2014-790 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905250 ER PT J AU Morgan, T Meyskens, FL Hoefs, J Hu, KQ Hassanein, T Boyer, TD Pimstone, NR Osann, K Gonzalez, R Rodriguez, LM AF Morgan, Timothy Meyskens, Frank L. Hoefs, John Hu, Ke-Qin Hassanein, Tarek Boyer, Thomas D. Pimstone, Neville R. Osann, Kathy Gonzalez, Rachel Rodriguez, L. M. TI SAMe versus placebo for the reduction of serum AFP in patients with hepatitis C cirrhosis and moderately elevated AFP: A randomized, placebo-controlled, double-blind phase II trial SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Morgan, Timothy; Meyskens, Frank L.; Hoefs, John; Hu, Ke-Qin; Osann, Kathy] Univ Calif Irvine, Orange, CA 92668 USA. [Hassanein, Tarek] Univ Calilfornia San Diego, San Diego, CA USA. [Boyer, Thomas D.] Univ Arizona Hlth Sci Ctr, Tucson, AZ USA. [Pimstone, Neville R.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Gonzalez, Rachel] VA Long Beach Healthcare Syst, Long Beach, CA USA. [Rodriguez, L. M.] Natl Canc Inst DCP GOCRG, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3247 DI 10.1158/1538-7445.AM2014-3247 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200248 ER PT J AU Mu, XJ Van Allen, E Wagle, N Chong, C Butaney, M Farlow, D Getz, G Janne, PA Garraway, LA AF Mu, Xinmeng Jasmine Van Allen, Eli Wagle, Nikhil Chong, Curtis Butaney, Mohit Farlow, Deborah Getz, Gad Jaenne, Pasi A. Garraway, Levi A. TI Heterogeneity of resistance mechanisms in lung adenocarcinoma patients with acquired resistance to EGFR inhibitors SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Mu, Xinmeng Jasmine; Farlow, Deborah; Getz, Gad] Broad Inst MIT & Harvard, Cambridge, MA USA. [Van Allen, Eli; Wagle, Nikhil; Chong, Curtis; Butaney, Mohit; Jaenne, Pasi A.; Garraway, Levi A.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2371 DI 10.1158/1538-7445.AM2014-2371 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903096 ER PT J AU Mudge, D Kieran, MW Bielenberg, D Benny, O Dalli, J Huang, S Serhan, CN Panigrahy, D AF Mudge, Dayna Kieran, Mark W. Bielenberg, Diane Benny, Ofra Dalli, Jesmond Huang, Sui Serhan, Charles N. Panigrahy, Dipak TI Maresin 1: a potent endogenous anti-inflammatory and pro-resolving inhibitor of primary tumor growth and metastasis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Mudge, Dayna; Panigrahy, Dipak] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Vasc Biol Res, Boston, MA 02215 USA. [Kieran, Mark W.] Harvard Univ, Sch Med, DFCI, Pediat Oncol, Boston, MA USA. [Bielenberg, Diane; Benny, Ofra] Harvard Univ, Sch Med, Boston Childrens Hosp, Vasc Biol Program, Boston, MA USA. [Dalli, Jesmond; Serhan, Charles N.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Therapeut & Reperfus Injury, Boston, MA 02115 USA. [Huang, Sui] Inst Syst Biol, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1170 DI 10.1158/1538-7445.AM2014-1170 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900408 ER PT J AU Mysore, VS Nickols, NG Szablowski, J Dervan, P Lichtenstein, A Frost, PJ AF Mysore, Veena S. Nickols, Nicholas G. Szablowski, Jerzy Dervan, Peter Lichtenstein, Alan Frost, Patrick J. TI Targeting hypoxia-mediated gene transcription with a novel polyamide drug designed to disrupt the HIF1 alpha/beta heterodimer binding overcomes resistance to hypoxia in myeloma cell lines SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Mysore, Veena S.; Lichtenstein, Alan; Frost, Patrick J.] Greater Los Angeles VA Med Ctr, Los Angeles, CA USA. [Nickols, Nicholas G.] Univ Calif Los Angeles, Los Angeles, CA USA. [Szablowski, Jerzy; Dervan, Peter] CALTECH, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5132 DI 10.1158/1538-7445.AM2014-5132 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204085 ER PT J AU Na, YJ Kwok, T Awtrey, C Strasfeld, DB Ferrer, JM Lee, D Birrer, MJ AF Na, Youngjeong Kwok, Tim Awtrey, Christopher Strasfeld, David B. Ferrer, Jorge M. Lee, David Birrer, Michael J. TI Identification of microscopic ovarian tumor foci utilizing a novel imaging device in a murine ovarian cancer model, an opportunity to improve optimal cytoreduction SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Na, Youngjeong; Kwok, Tim; Birrer, Michael J.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Awtrey, Christopher] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Strasfeld, David B.; Ferrer, Jorge M.; Lee, David] Lumicell Inc, Wellesley, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2056 DI 10.1158/1538-7445.AM2014-2056 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902268 ER PT J AU Nakayama, S Sng, NJ Carretero, J Welner, R Hayashi, Y Yamamoto, M Alistair, TJ Yamaguchi, N Yasuda, H Danan, LA Soejima, K Ross, SA Daniel, CB Wong, KK Kobayashi, SS AF Nakayama, Sohei Sng, Natasha J. Carretero, Julian Welner, Robert Hayashi, Yuichiro Yamamoto, Mihoko Alistair, Tan J. Yamaguchi, Norihiro Yasuda, Hiroyuki Li Danan Soejima, Kenzo Ross, Soo A. Daniel, Costa B. Wong, Kwok-Kin Kobayashi, Susumu S. TI beta-catenin plays an important role in lung tumor development induced by EGFR mutations SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Nakayama, Sohei; Sng, Natasha J.; Welner, Robert; Yamamoto, Mihoko; Alistair, Tan J.; Yamaguchi, Norihiro; Yasuda, Hiroyuki; Daniel, Costa B.; Kobayashi, Susumu S.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Carretero, Julian] Univ Valencia, E-46100 Burjassot, Spain. [Hayashi, Yuichiro; Soejima, Kenzo] Keio Univ, Sch Med, Tokyo, Japan. [Li Danan; Wong, Kwok-Kin] Dana Farber Canc Inst, Boston, MA 02115 USA. [Ross, Soo A.] Natl Univ Singapore, Singapore 117548, Singapore. RI Carretero, Julian/N-5214-2014 OI Carretero, Julian/0000-0001-7269-8506 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 968 DI 10.1158/1538-7445.AM2014-968 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905434 ER PT J AU Nissim, S Wucherpfennig, J Wang, XX Kimmelman, A Goessling, W AF Nissim, Sahar Wucherpfennig, Julia Wang, Xiao-Xu Kimmelman, Alec Goessling, Wolfram TI The role of NR5a2 in pancreas development and carcinogenesis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Nissim, Sahar; Wucherpfennig, Julia] Brigham & Womens Hosp, Boston, MA 02115 USA. [Wang, Xiao-Xu; Kimmelman, Alec] Dana Farber Canc Inst, Boston, MA 02115 USA. [Goessling, Wolfram] Brigham & Womens Hosp, Dana Farber Canc Inst, Harvard Stem Cell Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1953 DI 10.1158/1538-7445.AM2014-1953 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902168 ER PT J AU Ojesina, AI Murray, B Bjorge, L Woie, K Krakstad, C Lichtenstein, L Pedamallu, CS Taylor-Weiner, A Freeman, SS Cherniack, AD Lawrence, MS Cibulskis, K Carter, SL Walline, H Carey, TE Vintermyr, OK Bertelsen, B Crum, CP Getz, G Meyerson, M Salvesen, HB AF Ojesina, Akinyemi I. Murray, Bradley Bjorge, Line Woie, Kathrine Krakstad, Camilla Lichtenstein, Lee Pedamallu, Chandra Sekhar Taylor-Weiner, Amaro Freeman, Samuel S. Cherniack, Andrew D. Lawrence, Michael S. Cibulskis, Kristian Carter, Scott L. Walline, Heather Carey, Thomas E. Vintermyr, Olav K. Bertelsen, Bjorn Crum, Christopher P. Getz, Gad Meyerson, Matthew Salvesen, Helga B. TI Relationships between somatic genomic alterations, tumor stage and progression-free survival in cervical cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Ojesina, Akinyemi I.; Pedamallu, Chandra Sekhar; Cherniack, Andrew D.; Meyerson, Matthew] Broad Inst, Dana Farber Canc Inst, Cambridge, MA USA. [Murray, Bradley; Lichtenstein, Lee; Taylor-Weiner, Amaro; Freeman, Samuel S.; Lawrence, Michael S.; Cibulskis, Kristian; Carter, Scott L.] Broad Inst, Cambridge, MA USA. [Bjorge, Line; Woie, Kathrine; Krakstad, Camilla; Vintermyr, Olav K.; Bertelsen, Bjorn; Salvesen, Helga B.] Univ Bergen, Haukeland Univ Hosp, Bergen, Norway. [Walline, Heather; Carey, Thomas E.] Univ Michigan, Ann Arbor, MI 48109 USA. [Crum, Christopher P.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Getz, Gad] Massachusetts Gen Hosp, Broad Inst, Cambridge, MA USA. RI Bjorge, Line/C-1307-2017; salvesen, Helga/C-1187-2017 OI Bjorge, Line/0000-0002-0240-2770; salvesen, Helga/0000-0002-4438-8831 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4692 DI 10.1158/1538-7445.AM2014-4692 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203165 ER PT J AU Palakurthi, SS Liu, JF Zeng, Q Zhou, S Ivanova, E Paweletz, C Murgo, J Evangelista, J Curtis, J Piao, H Gokhale, P English, JM Kirschmeier, P Wong, KK Matulonis, UA Drapkin, R AF Palakurthi, Sangeetha S. Liu, Joyce F. Zeng, Qing Zhou, Shan Ivanova, Elena Paweletz, Cloud Murgo, John Evangelista, Justin Curtis, Jennifer Piao, Huiying Gokhale, Prafulla English, Jessie M. Kirschmeier, Paul Wong, Kwok-Kin Matulonis, Ursula A. Drapkin, Ronny TI Patient derived xenograft model platform of high grade serous ovarian cancer supporting discovery of targeted therapies and biomarkers SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Palakurthi, Sangeetha S.; Zeng, Qing; Zhou, Shan; Ivanova, Elena; Paweletz, Cloud; Murgo, John; Evangelista, Justin; Gokhale, Prafulla; English, Jessie M.; Kirschmeier, Paul; Wong, Kwok-Kin] Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA USA. [Liu, Joyce F.; Piao, Huiying; Matulonis, Ursula A.; Drapkin, Ronny] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Curtis, Jennifer] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. [Drapkin, Ronny] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. RI Drapkin, Ronny/E-9944-2016 OI Drapkin, Ronny/0000-0002-6912-6977 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1202 DI 10.1158/1538-7445.AM2014-1202 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900440 ER PT J AU Paraiso, KHT Das Thakur, M John, JK Fang, B Koomen, JM Fedorenko, IV Tsao, H Flaherty, KT Messina, JL Pasquale, EM Villagra, A Kirkwood, JM Meier, F Sloot, S Gibney, GT Stuart, D Tawbi, H Smalley, KSM AF Paraiso, Kim H. T. Das Thakur, Meghna John, Jobin K. Fang, Bin Koomen, John M. Fedorenko, Inna V. Tsao, Hensin Flaherty, Keith T. Messina, Jane L. Pasquale, Elena M. Villagra, Alejandro Kirkwood, John M. Meier, Friedegund Sloot, Sarah Gibney, Geoffrey T. Stuart, Darrin Tawbi, Hussein Smalley, Keiran S. M. TI MAPK inhibitor resistance leads to ligand-independent Ephrin A2 receptor signaling and the formation of new melanoma metastases SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Paraiso, Kim H. T.; John, Jobin K.; Fang, Bin; Koomen, John M.; Fedorenko, Inna V.; Messina, Jane L.; Villagra, Alejandro; Sloot, Sarah; Gibney, Geoffrey T.; Smalley, Keiran S. M.] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. [Das Thakur, Meghna; Stuart, Darrin] Novartis Inst Biomed Res, Emeryville, CA USA. [Tsao, Hensin; Flaherty, Keith T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Pasquale, Elena M.] Sanford Burnham Inst, La Jolla, CA USA. [Kirkwood, John M.; Tawbi, Hussein] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. [Meier, Friedegund] Univ Tubingen, Tubingen, Germany. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1610 DI 10.1158/1538-7445.AM2014-1610 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901333 ER PT J AU Parpart, ST Roessler, S Dong, F Rao, V Ji, JF Qin, LX Ye, QH Tang, ZY Jia, HL Wang, XW AF Parpart, Sonya T. Roessler, Stephanie Dong, Fei Rao, Vinay Ji, Junfang Qin, Lun-Xiu Ye, Qing-Hai Tang, Zhao-You Jia, Hu-Liang Wang, Xin Wei TI Modulation of miR-29 expression by alpha-fetoprotein is linked to the hepatocellular carcinoma epigenome SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Parpart, Sonya T.; Wang, Xin Wei] NIH, Bethesda, MD USA. [Roessler, Stephanie] Heidelberg Univ, Inst Pathol, Heidelberg, Germany. [Dong, Fei] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Rao, Vinay] UConn Hlth Ctr, Dept Internal Med, Farmington, CT USA. [Ji, Junfang] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Qin, Lun-Xiu; Ye, Qing-Hai; Tang, Zhao-You; Jia, Hu-Liang] Fudan Univ, Liver Canc Inst, Shanghai 200032, Peoples R China. [Qin, Lun-Xiu; Ye, Qing-Hai; Tang, Zhao-You; Jia, Hu-Liang] Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5183 DI 10.1158/1538-7445.AM2014-5183 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204134 ER PT J AU Patnaik, A Loda, M Kung, J Wu, J Taplin, M Kantoff, P Cantley, L Balk, S Bubley, G AF Patnaik, Akash Loda, Massimo Kung, Justin Wu, Jim Taplin, MaryEllen Kantoff, Philip Cantley, Lewis Balk, Steven Bubley, Glenn TI A Phase Ib study of BKM120 combined with abiraterone acetate for castrate-resistant, metastatic prostate cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Patnaik, Akash; Kung, Justin; Wu, Jim; Balk, Steven; Bubley, Glenn] Harvard Univ, Sch Med, Beth Israel Deaconess Med Center, Boston, MA USA. [Loda, Massimo; Taplin, MaryEllen; Kantoff, Philip] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Cantley, Lewis] Weill Cornell Med Coll, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT418 DI 10.1158/1538-7445.AM2014-CT418 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205124 ER PT J AU Patnaik, A Rosen, LS Tolaney, SM Tolcher, AW Goldman, JW Gandhi, L Papadopoulos, KP Beeram, M Rasco, DW Myrand, SP Kulanthaivel, P Li, L Frenzel, M Cronier, DM Chan, EM Flaherty, KT Wen, PY Shapiro, GI AF Patnaik, Amita Rosen, Lee S. Tolaney, Sara M. Tolcher, Anthony W. Goldman, Jonathan W. Gandhi, Leena Papadopoulos, Kyriakos P. Beeram, Muralidhar Rasco, Drew W. Myrand, Scott P. Kulanthaivel, Palaniappan Li, Lily Frenzel, Martin Cronier, Damien M. Chan, Edward M. Flaherty, Keith T. Wen, Patrick Y. Shapiro, Geoffrey I. TI Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with metastatic breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Patnaik, Amita; Tolcher, Anthony W.; Papadopoulos, Kyriakos P.; Beeram, Muralidhar; Rasco, Drew W.] START, San Antonio, TX USA. [Rosen, Lee S.; Goldman, Jonathan W.] Univ Calif Los Angeles, Santa Monica, CA USA. [Tolaney, Sara M.; Gandhi, Leena; Wen, Patrick Y.; Shapiro, Geoffrey I.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Myrand, Scott P.; Kulanthaivel, Palaniappan; Li, Lily; Frenzel, Martin; Cronier, Damien M.; Chan, Edward M.] Eli Lilly & Co, Indianapolis, IN 46285 USA. [Flaherty, Keith T.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. NR 0 TC 2 Z9 2 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT232 DI 10.1158/1538-7445.AM2014-CT232 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205059 ER PT J AU Paweletz, CP Oxnard, GR Kuang, YN O'Connell, A Yanagita, M Messineo, MM Kirschmeier, P English, JM Jackman, DM Janne, PA AF Paweletz, Cloud P. Oxnard, Geoffrey R. Kuang, Yanan O'Connell, Allison Yanagita, Masahiko Messineo, Melissa M. Kirschmeier, Paul English, Jessie M. Jackman, David M. Jaenne, Pasi A. TI Serial monitoring of EGFR mutations in plasma and matched tissue from EGFR mutant non-small cell lung cancer patients on erlotinib SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Paweletz, Cloud P.; Kuang, Yanan; O'Connell, Allison; Messineo, Melissa M.; Kirschmeier, Paul; English, Jessie M.] Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA USA. [Oxnard, Geoffrey R.; Yanagita, Masahiko; Jackman, David M.; Jaenne, Pasi A.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 939 DI 10.1158/1538-7445.AM2014-939 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905402 ER PT J AU Peng, HZ Farrooji, MTZ Osborne, MJ Prokop, JW McDonald, PC Karar, J Hou, ZY He, M Kebebew, E Orntoft, T Herlyn, M Caton, AJ Fredericks, W Malkowicz, B Paterno, CS Carolin, AS Speicher, DW Skordalakes, E Huang, QH Dedhar, SS Borden, KLB Rauscher, FJ AF Peng, Hongzhuang Farrooji, Mehdi Taleb Zadeh Osborne, Michael J. Prokop, Jeremy W. McDonald, Paul C. Karar, Jayashree Hou, Zhaoyuan He, Mei Kebebew, Electron Orntoft, Torben Herlyn, Meenhard Caton, Andrew J. Fredericks, William Malkowicz, Bruce Paterno, Christopher S. Carolin, Alexandra S. Speicher, David W. Skordalakes, Emmanuel Huang, Qihong Dedhar, Shoukat S. Borden, Katherine L. B. Rauscher, Frank J. TI LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Peng, Hongzhuang; Karar, Jayashree; Hou, Zhaoyuan; Herlyn, Meenhard; Caton, Andrew J.; Paterno, Christopher S.; Carolin, Alexandra S.; Speicher, David W.; Skordalakes, Emmanuel; Huang, Qihong; Rauscher, Frank J.] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA. [Farrooji, Mehdi Taleb Zadeh; Osborne, Michael J.] Univ Montreal, Inst Res Immunol & Canc, Dept Pathol & Cell Biol, Montreal, PQ, Canada. [Prokop, Jeremy W.] Med Coll Wisconsin, Human Mol & Genet Ctr, Milwaukee, WI USA. [McDonald, Paul C.; Dedhar, Shoukat S.] British Columbia Canc Res Ctr, Dept Integrat Oncol, Vancouver, BC V5Z 1L3, Canada. [He, Mei; Kebebew, Electron] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. [Orntoft, Torben] Aarhus Univ Hosp, Skejby, Denmark. [Fredericks, William; Malkowicz, Bruce] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA. [Fredericks, William; Malkowicz, Bruce] Vet Affairs Med Ctr, Philadelphia, PA USA. [Borden, Katherine L. B.] Univ Montreal, Inst Res Immunol & Canc, Dept Pathol & Cell Biol, Vancouver, PQ, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 992 DI 10.1158/1538-7445.AM2014-992 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905460 ER PT J AU Petrocca, F Altschuler, G Tan, SM Mendillo, ML Yan, HH Jerry, DJ Kung, AL Hide, W Ince, TA Lieberman, J AF Petrocca, Fabio Altschuler, Gabriel Tan, Shen Mynn Mendillo, Marc L. Yan, Haoheng Jerry, D. Joseph Kung, Andrew L. Hide, Winston Ince, Tan A. Lieberman, Judy TI Screening for triple negative breast cancer vulnerabilities SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Petrocca, Fabio; Tan, Shen Mynn; Lieberman, Judy] Harvard Univ, Sch Med, Boston, MA USA. [Altschuler, Gabriel; Hide, Winston] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Mendillo, Marc L.] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Yan, Haoheng; Jerry, D. Joseph] Univ Massachusetts, Amherst, MA 01003 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Kung, Andrew L.] Childrens Hosp, Boston, MA 02115 USA. [Ince, Tan A.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA SY43-03 DI 10.1158/1538-7445.AM2014-SY43-03 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205487 ER PT J AU Place, CS Cowley, GS Root, DE Garraway, LA AF Place, Chelsea S. Cowley, Glenn S. Root, David E. Garraway, Levi A. TI Synthetic lethal RNAi screens to nominate potential therapeutic combinations for uveal melanoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Place, Chelsea S.] Harvard Univ, Sch Med, Boston, MA USA. [Cowley, Glenn S.; Root, David E.] Broad Inst Harvard & MIT, Cambridge, MA USA. [Garraway, Levi A.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3429 DI 10.1158/1538-7445.AM2014-3429 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200428 ER PT J AU Pop, M Stransky, N Garvie, C Theurillat, JP Lewis, T Zhong, C Culyba, E Lin, F Daniels, D Pagliarini, R Ronco, L Koehler, A Garraway, L AF Pop, Marius Stransky, Nicolas Garvie, Colin Theurillat, Jean-Philippe Lewis, Timothy Zhong, Cheng Culyba, Elizabeth Lin, Fallon Daniels, Douglas Pagliarini, Raymond Ronco, Lucienne Koehler, Angela Garraway, Levi TI A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Pop, Marius; Theurillat, Jean-Philippe; Garraway, Levi] Dana Farber Canc Inst, Boston, MA 02115 USA. [Stransky, Nicolas; Garvie, Colin; Lewis, Timothy; Zhong, Cheng; Culyba, Elizabeth; Daniels, Douglas; Ronco, Lucienne; Koehler, Angela] Broad Inst, Cambridge, MA USA. [Lin, Fallon; Pagliarini, Raymond] Novartis Inst BioMed Res, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2519 DI 10.1158/1538-7445.AM2014-2519 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903254 ER PT J AU Preston, MA Cheng, JS Barrisford, G Sanchez, A Feldman, AS Rodriguez, D Choueiri, TK Stampfer, M Willett, WC Cho, EY AF Preston, Mark A. Cheng, Jed-Sian Barrisford, Glen Sanchez, Alex Feldman, Adam S. Rodriguez, Dayron Choueiri, Toni K. Stampfer, Meir Willett, Walter C. Cho, Eunyoung TI Nonsteroidal anti-inflammatory drug (NSAID) use and risk of lethal renal cell carcinoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Preston, Mark A.; Cheng, Jed-Sian; Barrisford, Glen; Sanchez, Alex; Feldman, Adam S.; Rodriguez, Dayron] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Choueiri, Toni K.] Dana Farber Canc Ctr, Boston, MA USA. [Stampfer, Meir; Willett, Walter C.; Cho, Eunyoung] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-279 DI 10.1158/1538-7445.AM2014-LB-279 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205310 ER PT J AU Purrington, KS Yannoukakos, D Carpenter, J Nevanlinna, H Cox, A Severi, G Ambrosone, C Toland, AE Godwin, AK Brauch, H Fasching, PA Miron, P Chang-Claude, J Martin, NG Montgomery, GW Kristensen, V Anton-Culver, H Goodfellow, P Olson, JE Sicotte, H Prodduturi, N Visscher, DW Eckel-Passow, JE Anderson, SK Slettedahl, S Olswold, C Wang, XS Pankratz, VS Slager, S Zheng, W Mannermaa, A Hamann, U Eccles, DM Vachon, CM Couch, FJ AF Purrington, Kristen S. Yannoukakos, Drakoulis Carpenter, Jane Nevanlinna, Heli Cox, Angela Severi, Gianluca Ambrosone, Christine Toland, Amanda Ewart Godwin, Andrew K. Brauch, Hiltrud Fasching, Peter A. Miron, Penelope Chang-Claude, Jenny Martin, Nicholas G. Montgomery, Grant W. Kristensen, Vessela Anton-Culver, Hoda Goodfellow, Paul Olson, Janet E. Sicotte, Hugues Prodduturi, Naresh Visscher, Daniel W. Eckel-Passow, Jeanette E. Anderson, S. Keith Slettedahl, Seth Olswold, Curtis Wang, Xianshu Pankratz, V. Shane Slager, Susan Zheng, Wei Mannermaa, Arto Hamann, Ute Eccles, Diana M. Vachon, Celine M. Couch, Fergus J. TI Expression quantitative trait locus analysis of triple negative breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Purrington, Kristen S.] Wayne State Univ, Detroit, MI USA. [Purrington, Kristen S.] Karmanos Canc Inst, Detroit, MI USA. [Yannoukakos, Drakoulis] Natl Ctr Sci Res Demokritos, Athens, Greece. [Carpenter, Jane] Univ Sydney, Westmead Millennium Inst, Westmead, NSW 2145, Australia. [Nevanlinna, Heli] Univ Helsinki, Helsinki, Finland. [Nevanlinna, Heli] Univ Helsinki, Cent Hosp, Helsinki, Finland. [Cox, Angela] Univ Sheffield, Yorkshire Canc Res Sheffield Canc Res Ctr, Canc Res UK, Sheffield, S Yorkshire, England. [Severi, Gianluca] Canc Council Victoria, Melbourne, Vic, Australia. [Ambrosone, Christine] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Toland, Amanda Ewart] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Godwin, Andrew K.] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA. [Brauch, Hiltrud] Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany. [Brauch, Hiltrud] Univ Tubingen, Tubingen, Germany. [Fasching, Peter A.] Univ Erlangen Nurnberg, Univ Hosp Erlangen, Univ Breast Ctr Franconia, D-91054 Erlangen, Germany. [Miron, Penelope] Dana Farber Canc Inst, Boston, MA 02115 USA. [Chang-Claude, Jenny; Hamann, Ute] German Canc Res Ctr, Heidelberg, Germany. [Martin, Nicholas G.; Montgomery, Grant W.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Kristensen, Vessela] Radiumhosp, Oslo Univ Hosp, Inst Canc Res, Oslo, Norway. [Anton-Culver, Hoda] Univ Calif Irvine, Irvine, CA USA. [Goodfellow, Paul] Washington Univ, Sch Med, Barnes Jewish Hosp, St Louis, MO USA. [Goodfellow, Paul] Siteman Canc Ctr, St Louis, MO USA. [Olson, Janet E.; Sicotte, Hugues; Prodduturi, Naresh; Visscher, Daniel W.; Eckel-Passow, Jeanette E.; Anderson, S. Keith; Slettedahl, Seth; Olswold, Curtis; Wang, Xianshu; Pankratz, V. Shane; Slager, Susan; Vachon, Celine M.; Couch, Fergus J.] Mayo Clin, Rochester, MN USA. [Zheng, Wei] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA. [Mannermaa, Arto] Univ Eastern Finland, Kuopio, Finland. [Eccles, Diana M.] Univ Southampton, Southampton, Hants, England. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3266 DI 10.1158/1538-7445.AM2014-3266 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200266 ER PT J AU Quiroz-Zarate, A Harshfield, BJ Hu, R Knoblauch, N Beck, AH Carey, V Hankinson, SE Tamimi, RM Hunter, DJ Quackenbush, J Hazra, A AF Quiroz-Zarate, Alejandro Harshfield, Benjamin J. Hu, Rong Knoblauch, Nick Beck, Andrew H. Carey, Vincent Hankinson, Susan E. Tamimi, Rulla M. Hunter, David J. Quackenbush, John Hazra, Aditi TI QTLs in breast tumor and breast normal adjacent FFPE specimens from the Nurses' Health Study SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Quiroz-Zarate, Alejandro; Quackenbush, John] Dana Farber Canc Inst, Boston, MA 02115 USA. [Harshfield, Benjamin J.; Hu, Rong; Carey, Vincent; Tamimi, Rulla M.; Hunter, David J.; Hazra, Aditi] Brigham & Womens Hosp, Boston, MA 02115 USA. [Knoblauch, Nick; Beck, Andrew H.] Beth Israel Deconess Med Ctr, Boston, MA USA. [Hankinson, Susan E.] Univ Massachusetts, Amherst, MA 01003 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3269 DI 10.1158/1538-7445.AM2014-3269 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910200269 ER PT J AU Riester, M Wei, W Culhane, AC Trippa, L Michor, F Huttenhower, C Parmigiani, G Birrer, M AF Riester, Markus Wei, Wei Culhane, Aedin C. Trippa, Lorenzo Michor, Franziska Huttenhower, Curtis Parmigiani, Giovanni Birrer, Michael TI Risk prediction for late-stage ovarian cancer by meta-analysis of 1,525 patient samples SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Riester, Markus; Culhane, Aedin C.; Trippa, Lorenzo; Michor, Franziska; Huttenhower, Curtis; Parmigiani, Giovanni] Dana Farber Canc Inst, Boston, MA 02115 USA. [Wei, Wei; Birrer, Michael] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2355 DI 10.1158/1538-7445.AM2014-2355 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903078 ER PT J AU Rodriguez, M Fiskus, W Sharma, S Qi, J Schaub, LJ Shah, B Devaraj, SGT Liu, K Iyer, S Bradner, JE Bhalla, KN AF Rodriguez, Melissa Fiskus, Warren Sharma, Sunil Qi, Jun Schaub, Leasha J. Shah, Bhavin Devaraj, Santhana G. T. Liu, Ka Iyer, Swaminathan Bradner, James E. Bhalla, Kapil N. TI BRD4 antagonist-based therapy exerts lethal activity against FLT3 mutation expressing AML cells resistant to FLT3 tyrosine kinase inhibitors SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Rodriguez, Melissa; Fiskus, Warren; Schaub, Leasha J.; Shah, Bhavin; Devaraj, Santhana G. T.; Liu, Ka; Iyer, Swaminathan; Bhalla, Kapil N.] Houston Methodist Res Inst, Houston, TX USA. [Sharma, Sunil] Huntsman Canc Inst, Salt Lake City, UT USA. [Qi, Jun; Bradner, James E.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1721 DI 10.1158/1538-7445.AM2014-1721 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901443 ER PT J AU Rosenberg, LM Bertagnolli, MM Cho, NL AF Rosenberg, Laura M. Bertagnolli, Monica M. Cho, Nancy L. TI Sorafenib suppresses desmoid tumor growth and invasion via inhibition of ERK signaling SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Rosenberg, Laura M.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bertagnolli, Monica M.; Cho, Nancy L.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3794 DI 10.1158/1538-7445.AM2014-3794 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201284 ER PT J AU Rothenberg, SM McFadden, DG Palmer, EL Daniels, GH Wirth, LJ AF Rothenberg, Stephen M. McFadden, David G. Palmer, Edwin L. Daniels, Gilbert H. Wirth, Lori J. TI Dabrafenib stimulates radioiodine uptake in BRAF V600E mutant advanced papillary thyroid cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Rothenberg, Stephen M.; Wirth, Lori J.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [McFadden, David G.; Daniels, Gilbert H.] Massachusetts Gen Hosp, Div Endocrine, Boston, MA 02114 USA. [Palmer, Edwin L.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT234 DI 10.1158/1538-7445.AM2014-CT234 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205061 ER PT J AU Rothenberg, SM Concannon, K Cullen, S Turke, AB Faber, AC Engelman, JA Maheswaran, S Haber, DA AF Rothenberg, Stephen Michael Concannon, Kyle Cullen, Sarah Turke, Alexa B. Faber, Anthony C. Engelman, Jeffrey A. Maheswaran, Shyamala Haber, Daniel A. TI Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6 dependent survival pathways SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Rothenberg, Stephen Michael; Concannon, Kyle; Cullen, Sarah; Turke, Alexa B.; Faber, Anthony C.; Engelman, Jeffrey A.; Maheswaran, Shyamala; Haber, Daniel A.] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4773 DI 10.1158/1538-7445.AM2014-4773 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203244 ER PT J AU Roy, R Zurakowski, D Kulke, M Moses, MA AF Roy, Roopali Zurakowski, David Kulke, Matthew Moses, Marsha A. TI Urinary ADAM12 levels detect the presence of pancreatic cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Roy, Roopali; Zurakowski, David; Moses, Marsha A.] Harvard Univ, Sch Med, Boston Childrens Hosp, Boston, MA USA. [Kulke, Matthew] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 891 DI 10.1158/1538-7445.AM2014-891 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905351 ER PT J AU Sabbatino, F Wang, YY Wang, XH Flaherty, KT Pepin, D Scognamiglio, G Yu, L Cooper, ZA Pepe, S Kirkwood, JM Frederick, DT Wargo, JA Ferrone, S Ferrone, CR AF Sabbatino, Francesco Wang, Yangyang Wang, Xinhui Flaherty, Keith T. Pepin, David Scognamiglio, Giosue Yu, Ling Cooper, Zachary A. Pepe, Stefano Kirkwood, John M. Frederick, Dennie T. Wargo, Jennifer A. Ferrone, Soldano Ferrone, Cristina R. TI PDGFR alpha up-regulation mediated by Sonic Hedgehog Pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sabbatino, Francesco; Wang, Yangyang; Wang, Xinhui; Flaherty, Keith T.; Pepin, David; Frederick, Dennie T.; Ferrone, Soldano; Ferrone, Cristina R.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Scognamiglio, Giosue] Fdn G Pascale, Ist Nazl Tumori, Naples, Italy. [Yu, Ling] Southwest Univ, Inst Clean Energy & Adv Mat, Chongqing, Peoples R China. [Cooper, Zachary A.; Wargo, Jennifer A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Pepe, Stefano] Univ Salerno, I-84100 Salerno, Italy. [Kirkwood, John M.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. RI Yu, Ling/J-4286-2016; Scognamiglio, Giosue/K-8247-2016 OI Scognamiglio, Giosue/0000-0003-4376-111X NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3703 DI 10.1158/1538-7445.AM2014-3703 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201194 ER PT J AU Samuels, ML Taly, V Balaj, L Das, S Park, BH AF Samuels, Michael L. Taly, Valerie Balaj, Leonora Das, Saumya Park, Ben H. TI Quantitative cancer analysis using digital PCR: Absolute counting of DNA (solid tumors and liquid biopsies in glioma, breast, and colon cancer) and RNA (mRNA and miRNA using One-Step RT-dPCR) SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Samuels, Michael L.] RainDance Technol Inc, Billerica, MA USA. [Taly, Valerie] Univ Paris 05, Paris, France. [Balaj, Leonora] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Das, Saumya] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Park, Ben H.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5316 DI 10.1158/1538-7445.AM2014-5316 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204237 ER PT J AU Sanchez-Rivera, FJ Ryan, J Soto-Feliciano, YM Feldser, DM Hemann, MT Letai, A Jacks, T AF Sanchez-Rivera, Francisco J. Ryan, Jeremy Soto-Feliciano, Yadira M. Feldser, David M. Hemann, Michael T. Letai, Anthony Jacks, Tyler TI The level of mitochondrial apoptotic priming determines cell fate upon p53 restoration SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sanchez-Rivera, Francisco J.; Soto-Feliciano, Yadira M.; Hemann, Michael T.; Jacks, Tyler] MIT Koch Inst Integrat Canc Res, Cambridge, MA USA. [Ryan, Jeremy; Letai, Anthony] Dana Farber Canc Inst, Boston, MA 02115 USA. [Feldser, David M.] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2961 DI 10.1158/1538-7445.AM2014-2961 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904233 ER PT J AU Sanidas, I Polytarchou, C Hatziapostolou, M Ezell, SA Kottakis, F Hu, L Guo, AL Xie, JX Comb, MJ Iliopoulos, D Tsichlis, PN AF Sanidas, Ioannis Polytarchou, Christos Hatziapostolou, Maria Ezell, Scott A. Kottakis, Filippos Hu, Lan Guo, Ailan Xie, Jianxin Comb, Michael J. Iliopoulos, Dimitrios Tsichlis, Philip N. TI A phosphoproteomics analysis reveals Akt isoform-specific signals that link RNA splicing to non-small cell lung cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sanidas, Ioannis; Ezell, Scott A.; Kottakis, Filippos; Tsichlis, Philip N.] Tufts Med Ctr, Boston, MA USA. [Polytarchou, Christos; Hatziapostolou, Maria; Iliopoulos, Dimitrios] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Hu, Lan] Dana Farber Canc Inst, Boston, MA 02115 USA. [Guo, Ailan; Xie, Jianxin; Comb, Michael J.] Cell Signaling Technol, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4777 DI 10.1158/1538-7445.AM2014-4777 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203248 ER PT J AU Scaltriti, M Tao, J Castel, P Radosevic-Robin, N Elkabets, M Auricchio, N Juric, D Penault-Llorca, F Baselga, J AF Scaltriti, Maurizio Tao, Jessica Castel, Pau Radosevic-Robin, Nina Elkabets, Moshe Auricchio, Neil Juric, Dejan Penault-Llorca, Frederique Baselga, Jose TI Blockade of EGFR and HER3 enhances PI3K/Akt antitumor activity in triple negative breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. Univ Auvergne, Clermont Ferrand, France. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA NG01 DI 10.1158/1538-7445.AM2014-NG01 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205434 ER PT J AU Schmidt, B Wei, L DePeralta, DK Hoshida, Y Lanuti, M Tanabe, KK Fuchs, BC AF Schmidt, Benjamin Wei, Lan DePeralta, Danielle K. Hoshida, Yujin Lanuti, Michael Tanabe, Kenneth K. Fuchs, Bryan C. TI Molecular subclasses of human hepatocellular carcinoma predict sensitivity to fibroblast growth factor receptor inhibition SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Schmidt, Benjamin; Wei, Lan; DePeralta, Danielle K.; Lanuti, Michael; Tanabe, Kenneth K.; Fuchs, Bryan C.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Hoshida, Yujin] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5435 DI 10.1158/1538-7445.AM2014-5435 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204352 ER PT J AU Schwitalla, S Tu, HC Viswanathan, S Zhu, H Qian, ZR Shah, S Ogino, S Daley, GQ AF Schwitalla, Sarah Tu, Ho-Chou Viswanathan, Srinivas Zhu, Hao Qian, Zhirong Shah, Samar Ogino, Shuji Daley, George Q. TI The pluripotency factor LIN28 promotes colorectal tumorigenesis and tumor progression SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Schwitalla, Sarah; Tu, Ho-Chou; Viswanathan, Srinivas; Zhu, Hao; Shah, Samar; Daley, George Q.] Harvard Univ, Sch Med, Boston Childrens Hosp, Boston, MA USA. [Qian, Zhirong; Ogino, Shuji] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2975 DI 10.1158/1538-7445.AM2014-2975 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904248 ER PT J AU Seoane, M Raluy, LP Kaufmann, K Strauss, J Dierck, K Thomale, J Brandner, JM Schumacher, U Nollau, P Wild, PJ Zimmermann, M Du, JY Fisher, DE Horstmann, MA AF Seoane, Marcos Raluy, Laia Pagerols Kaufmann, Karoline Strauss, Julia Dierck, Kevin Thomale, Jueergen Brandner, Johanna M. Schumacher, Udo Nollau, Peter Wild, Peter J. Zimmermann, Martin Du, Jinyan Fisher, David E. Horstmann, Martin A. TI Regulation of the functional interface between nucleotide excision repair and transcription by MITF modulates melanoma growth SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Seoane, Marcos; Raluy, Laia Pagerols; Kaufmann, Karoline; Strauss, Julia; Dierck, Kevin; Horstmann, Martin A.] Childrens Canc Ctr Hamburg, Hamburg, Germany. [Thomale, Jueergen] Univ Duisburg Essen, Inst Cell Biol, Essen, Germany. [Brandner, Johanna M.] Univ Med Ctr Hamburg, Dept Dermatol, Hamburg, Germany. [Schumacher, Udo] Univ Med Ctr Hamburg, Inst Anat, Hamburg, Germany. [Nollau, Peter] Univ Med Ctr Hamburg, Inst Clin Chem, Hamburg, Germany. [Wild, Peter J.] Univ Zurich Hosp, Inst Surg Pathol, Zurich, Switzerland. [Zimmermann, Martin] Hannover Med Sch, Dept Pediat Hematol & Oncol, Hannover, Germany. [Du, Jinyan] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Fisher, David E.] Harvard Univ, Sch Med, Dept Dermatol, Cutaneous Biol Res Ctr,Mass Gen Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2950 DI 10.1158/1538-7445.AM2014-2950 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904222 ER PT J AU Sequist, LV Cassier, P Varga, A Tabernero, J Schellens, JH Delord, JP LoRusso, P Camidge, DR Medina, MH Schuler, M Campone, M Tian, GG Wong, S Corral, J Isaacs, R Sen, SK Porta, DG Kulkarni, SG Lefebvre, C Wolf, J AF Sequist, Lecia V. Cassier, Phillippe Varga, Andrea Tabernero, Josep Schellens, Jan H. Delord, Jean-Pierre LoRusso, Patricia Camidge, D. Ross Hidalgo Medina, Manuel Schuler, Martin Campone, Mario Tian, G. Gary Wong, Steven Corral, Jesus Isaacs, Randi Sen, Suman K. Porta, Diana Graus Kulkarni, Swarupa G. Lefebvre, Caroline Wolf, Juergen TI Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sequist, Lecia V.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Cassier, Phillippe] Ctr Leon Berard, F-69373 Lyon, France. [Varga, Andrea] Inst Gustave Roussy, Villejuif, France. [Tabernero, Josep] Vall dHebron Univ Hosp, Barcelona, Spain. [Schellens, Jan H.] Netherlands Canc Inst, Amsterdam, Netherlands. [Delord, Jean-Pierre] Inst Claudius Regaud, Toulouse, France. [LoRusso, Patricia] Karmanos Canc Inst, Detroit, MI USA. [Camidge, D. Ross] Univ Colorado, Aurora, CO USA. [Hidalgo Medina, Manuel] Spanish Natl Canc Res Ctr CNIO, Madrid, Spain. [Schuler, Martin] Univ Duisburg Essen, West German Canc Ctr, Essen, Germany. [Campone, Mario] Ctr Rene Gauducheau, F-44035 Nantes, France. [Tian, G. Gary] West Clin, Memphis, TN USA. [Wong, Steven] UCLA Med Ctr, Los Angeles, CA USA. [Corral, Jesus] Univ Hosp Virgen del Rocio, Seville, Spain. [Isaacs, Randi] Novartis OTM, E Hanover, NJ USA. [Sen, Suman K.; Kulkarni, Swarupa G.] Novartis Pharmaceut, E Hanover, NJ USA. [Porta, Diana Graus] NIBR Oncol, Basel, Switzerland. [Lefebvre, Caroline] Novartis OTM, Basel, Switzerland. [Wolf, Juergen] Univ Hosp Cologne, Cologne, Germany. NR 0 TC 18 Z9 18 U1 1 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT326 DI 10.1158/1538-7445.AM2014-CT326 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205091 ER PT J AU Shahbazi, J Scarlett, CJ Norris, M Liu, B Haber, M Tee, AE Carrier, A Biankin, AV London, WB Marshall, GM Lock, R Liu, T AF Shahbazi, Jeyran Scarlett, Christopher J. Norris, Murray Liu, Bing Haber, Michelle Tee, Andrew E. Carrier, Alice Biankin, Andrew V. London, Wendy B. Marshall, Glenn M. Lock, Richard Liu, Tao TI Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1 SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Shahbazi, Jeyran; Norris, Murray; Liu, Bing; Haber, Michelle; Tee, Andrew E.; Marshall, Glenn M.; Lock, Richard; Liu, Tao] Childrens Canc Inst Australia Med Res, Sydney, NSW, Australia. [Scarlett, Christopher J.] Univ Newcastle, Sch Environm & Life Sci, Food Bioact & Pancreat Canc Biol Grp, Newcastle, NSW 2300, Australia. [Carrier, Alice] INSERM, F-13258 Marseille, France. [Biankin, Andrew V.] Garvan Inst Med Res, Sydney, NSW, Australia. [London, Wendy B.] Childrens Oncol Grp Stat & Data Ctr, Boston, MA USA. [London, Wendy B.] Boston Childrens Hosp, Dana Farber Canc Inst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 5138 DI 10.1158/1538-7445.AM2014-5138 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910204091 ER PT J AU Shao, WL Schoumacher, M Hurov, K Lehar, J Yan-Neale, Y Mishina, Y Sonkin, D Korn, J Flemming, D Jones, M Antonakos, B Cooke, V Stump, M Danial, N Sellers, W AF Shao, Wenlin Schoumacher, Marie Hurov, Kristen Lehar, Joseph Yan-Neale, Yan Mishina, Yuji Sonkin, Dmitriy Korn, Joshua Flemming, Daisy Jones, Michael Antonakos, Brandon Cooke, Vessilina Stump, Mark Danial, Nika Sellers, William TI Inhibiting TNKS sensitizes KRAS mutant cancer cells to MEK inhibitors by suppressing FGFR2 feedback signaling SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Shao, Wenlin; Schoumacher, Marie; Hurov, Kristen; Lehar, Joseph; Yan-Neale, Yan; Mishina, Yuji; Sonkin, Dmitriy; Korn, Joshua; Flemming, Daisy; Jones, Michael; Antonakos, Brandon; Cooke, Vessilina; Stump, Mark; Sellers, William] Novartis Inst BioMed Res, Cambridge, MA USA. [Danial, Nika] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-107 DI 10.1158/1538-7445.AM2014-LB-107 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205142 ER PT J AU Shen, Y Nitta, M Li, J Futalan, D Steed, T Taich, Z Treiber, JM Stevens, D Schroeder, MA Sarkaria, JN Chen, HZ Jiang, T Carter, BS Esashi, F Wakosky, J Furnari, F Cavenee, WK Desai, A Chen, CC AF Shen, Ying Nitta, Masayuki Li, Jie Futalan, Diahnn Steed, Tyler Taich, Zack Treiber, Jeffrey M. Stevens, Deanna Schroeder, Mark A. Sarkaria, Jann N. Chen, Hong-Zhuan Jiang, Tao Carter, Bob S. Esashi, Fumiko Wakosky, Jill Furnari, Frank Cavenee, Webster K. Desai, Arshad Chen, Clark C. TI Modulation of mitotic DNA damage as a paradigm for glioblastoma therapy SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Shen, Ying; Li, Jie; Futalan, Diahnn; Steed, Tyler; Taich, Zack; Treiber, Jeffrey M.; Carter, Bob S.; Chen, Clark C.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Nitta, Masayuki] Dana Farber Canc Inst, Boston, MA 02115 USA. [Stevens, Deanna; Wakosky, Jill; Furnari, Frank; Cavenee, Webster K.; Desai, Arshad] Ludwig Inst Canc Res, La Jolla, CA USA. [Schroeder, Mark A.; Sarkaria, Jann N.] Mayo Clin, Rochester, MN USA. [Chen, Hong-Zhuan] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China. [Jiang, Tao] Capital Med Univ, Beijing, Peoples R China. [Esashi, Fumiko] Univ Oxford, Oxford OX1 2JD, England. RI Li, Jie/L-1737-2015 OI Li, Jie/0000-0002-0590-9817 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2737 DI 10.1158/1538-7445.AM2014-2737 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903490 ER PT J AU Singh, JM Bui, AH Michaelson, JS AF Singh, Jolene M. Bui, Anthony H. Michaelson, James S. TI Comparison of high-resolution 3D X-ray microCT and tomosynthesis imaging: A breast phantom study SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Singh, Jolene M.; Bui, Anthony H.; Michaelson, James S.] Massachusetts Gen Hosp, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4299 DI 10.1158/1538-7445.AM2014-4299 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910202275 ER PT J AU Stein, E Tallman, M Pollyea, DA Flinn, IW Fathi, AT Stone, RM Levine, RL Agresta, S Schenkein, D Yang, H Fan, B Yen, K Botton, SD AF Stein, Eytan Tallman, Martin Pollyea, Daniel A. Flinn, Ian W. Fathi, Amir T. Stone, Richard M. Levine, Ross L. Agresta, Samuel Schenkein, David Yang, Hua Fan, Bin Yen, Kate Botton, Stephane D. TI Clinical safety and activity in a phase I trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein, in patients with IDH2 mutant positive advanced hematologic malignancies SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Stein, Eytan; Tallman, Martin; Levine, Ross L.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Pollyea, Daniel A.] Univ Colorado, Ctr Canc, Aurora, CO USA. [Flinn, Ian W.] Sarah Cannon Res Inst, Nashville, TN USA. [Fathi, Amir T.] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Boston, MA 02114 USA. [Stone, Richard M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Agresta, Samuel; Schenkein, David; Yang, Hua; Fan, Bin; Yen, Kate] Agios Pharmaceut, Cambridge, MA USA. [Botton, Stephane D.] Inst Gustave Roussy, Villejuif, France. NR 0 TC 1 Z9 1 U1 2 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT103 DI 10.1158/1538-7445.AM2014-CT103 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205028 ER PT J AU Sulciner, ML Mudge, DK Bielenberg, DR Benny, O Dalli, J Huang, S Serhan, CN Kieran, MW Panigrahy, D AF Sulciner, Megan L. Mudge, Dayna K. Bielenberg, Diane R. Benny, Ofra Dalli, Jesmond Huang, Sui Serhan, Charles N. Kieran, Mark W. Panigrahy, Dipak TI Cancer progression: The failure to resolve SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sulciner, Megan L.; Mudge, Dayna K.; Panigrahy, Dipak] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Bielenberg, Diane R.; Benny, Ofra] Boston Childrens Hosp, Boston, MA USA. [Dalli, Jesmond; Serhan, Charles N.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Huang, Sui] Inst Syst Biol, Seattle, WA USA. [Kieran, Mark W.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1664 DI 10.1158/1538-7445.AM2014-1664 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901386 ER PT J AU Sullivan, J Havrda, M Paolella, B Kettenbach, A Gerber, S Israel, MA AF Sullivan, Jaclyn Havrda, Matthew Paolella, Brenton Kettenbach, Arminja Gerber, Scott Israel, Mark A. TI Regulation of Id2 In the proliferation of glioma-initiating neural progenitor cells SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sullivan, Jaclyn; Havrda, Matthew; Kettenbach, Arminja; Gerber, Scott; Israel, Mark A.] Geisel Sch Med Dartmouth, Lebanon, NH USA. [Paolella, Brenton] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1402 DI 10.1158/1538-7445.AM2014-1402 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901134 ER PT J AU Sullivan, JP Nahed, BV Chi, AS Madden, MN Oliveira, SM Springer, S Wakimoto, H Bhere, D Shah, K Spuhler, P Shah, AM Louis, DN Toner, M Maheswaran, S Haber, DA AF Sullivan, James P. Nahed, Brian V. Chi, Andrew S. Madden, Marissa N. Oliveira, Samantha M. Springer, Simeon Wakimoto, Hiroaki Bhere, Deepak Shah, Khalid Spuhler, Phil Shah, Ajay M. Louis, David N. Toner, Mehmet Maheswaran, Shyamala Haber, Daniel A. TI Molecular characterization of circulating glioblastoma cells identifies a mesenchymal-like tumor cell subpopulation SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sullivan, James P.; Nahed, Brian V.; Chi, Andrew S.; Madden, Marissa N.; Oliveira, Samantha M.; Springer, Simeon; Wakimoto, Hiroaki; Bhere, Deepak; Shah, Khalid; Spuhler, Phil; Shah, Ajay M.; Louis, David N.; Toner, Mehmet; Maheswaran, Shyamala; Haber, Daniel A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4004 DI 10.1158/1538-7445.AM2014-4004 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201488 ER PT J AU Sun, Y Coleman, I Plymate, S Nelson, P AF Sun, Yu Coleman, Ilsa Plymate, Stephen Nelson, Peter TI DNA damage response in quiescent fibroblasts elicits a distinct secretory program and confers acquired resistance to cancer therapies SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Sun, Yu; Plymate, Stephen] Univ Washington, VA Puget Sound Healthcare Syst, Seattle, WA 98195 USA. [Coleman, Ilsa; Nelson, Peter] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 184 DI 10.1158/1538-7445.AM2014-184 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900181 ER PT J AU Tai, YT Acharya, C Zhong, MY Cea, M Cagnetta, A Richardson, P Munshi, NC Anderson, KC AF Tai, Yu-Tzu Acharya, Chirag Zhong, Mike Y. Cea, Michele Cagnetta, Antonia Richardson, Paul Munshi, Nikhil C. Anderson, Kenneth C. TI B-cell maturation antigen (BCMA) activation in human multiple myeloma cells promotes myeloma cell growth and survival in the bone marrow microenvironment via upregulated MCL-1 and NF kappa B signaling SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Tai, Yu-Tzu; Acharya, Chirag; Zhong, Mike Y.; Cea, Michele; Cagnetta, Antonia; Richardson, Paul; Munshi, Nikhil C.; Anderson, Kenneth C.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 972 DI 10.1158/1538-7445.AM2014-972 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905439 ER PT J AU Tai, YT Acharya, C Zhong, MY Cea, M Cagnetta, A Mayes, PA Craigen, J Gliddon, L Smothers, J Christie, AL Kung, AL Richardson, P Munshi, NC Anderson, KC AF Tai, Yu-Tzu Acharya, Chirag Zhong, Mike Y. Cea, Michele Cagnetta, Antonia Mayes, Patrick A. Craigen, Jenny Gliddon, Louise Smothers, James Christie, Amanda L. Kung, Andrew L. Richardson, Paul Munshi, Nikhil C. Anderson, Kenneth C. TI Novel anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent and selective anti-multiple myeloma activity via enhanced effector function and direct tumor cell killing SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Tai, Yu-Tzu; Acharya, Chirag; Zhong, Mike Y.; Cea, Michele; Cagnetta, Antonia; Christie, Amanda L.; Kung, Andrew L.; Richardson, Paul; Munshi, Nikhil C.; Anderson, Kenneth C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Mayes, Patrick A.; Smothers, James] GlaxoSmithKline, Oncol R&D, Philadelphia, PA USA. [Craigen, Jenny; Gliddon, Louise] GlaxoSmithKline, Biopharm Discovery, Brentford, Kent, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 644 DI 10.1158/1538-7445.AM2014-644 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905106 ER PT J AU Tangutoori, S Baldwin, P Korideck, H Cormack, R Makrigiorgos, MG Sridhar, S AF Tangutoori, Shifalika Baldwin, Paige Korideck, Houari Cormack, Robert Makrigiorgos, Mike G. Sridhar, Srinivas TI Nanoformulations of PARP inhibtors for cancer therapy SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Tangutoori, Shifalika; Baldwin, Paige; Sridhar, Srinivas] Northeastern Univ, Boston, MA 02115 USA. [Korideck, Houari; Cormack, Robert; Makrigiorgos, Mike G.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2397 DI 10.1158/1538-7445.AM2014-2397 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903123 ER PT J AU Tapias, LF Gilpin, SE Elliott, J Zachariah, R Zhou, HY Fuchs, BC Wei, L Deperalta, DK Kuruppu, KD Tanabe, KK Ott, HC Lanuti, M AF Tapias, Luis F. Gilpin, Sarah E. Elliott, Justin Zachariah, Roshini Zhou, Haiyu Fuchs, Bryan C. Wei, Lan Deperalta, Danielle K. Kuruppu, Kumudu D. Tanabe, Kenneth K. Ott, Harald C. Lanuti, Michael TI A 3D model for lung cancer based on decellularized lung scaffolds allows for in vitro testing of viral oncolysis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Tapias, Luis F.; Gilpin, Sarah E.; Elliott, Justin; Zachariah, Roshini; Zhou, Haiyu; Fuchs, Bryan C.; Wei, Lan; Deperalta, Danielle K.; Kuruppu, Kumudu D.; Tanabe, Kenneth K.; Ott, Harald C.; Lanuti, Michael] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2037 DI 10.1158/1538-7445.AM2014-2037 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902249 ER PT J AU Taylor-Weiner, AN Brastianos, PK Manley, PE Jones, RT Dias-Sangata, D Thorner, A Rodriguez, F Bernardo, L Schubert, L Stewart, C Keiran, M Hahn, WC Resnick, A Louis, D Sangata, S Getz, G AF Taylor-Weiner, Amaro N. Brastianos, Priscilla K. Manley, Peter E. Jones, Robert T. Dias-Sangata, Dora Thorner, Aaron Rodriguez, Fausto Bernardo, Lindsay Schubert, Laura Stewart, Chip Keiran, Mark Hahn, William C. Resnick, Adam Louis, David Sangata, Sandro Getz, Gad TI Exome sequencing reveals BRAF mutations in papillary craniopharyngiomas SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Taylor-Weiner, Amaro N.; Brastianos, Priscilla K.; Stewart, Chip; Resnick, Adam; Getz, Gad] Broad Inst, Boston, MA USA. [Manley, Peter E.; Thorner, Aaron; Schubert, Laura; Hahn, William C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Jones, Robert T.] Dana Farber Med Oncol, Boston, MA USA. [Dias-Sangata, Dora; Keiran, Mark; Sangata, Sandro] Harvard Univ, Sch Med, Boston, MA USA. [Rodriguez, Fausto] Johns Hopkins, Baltimore, MD USA. [Bernardo, Lindsay; Louis, David] Mass Gen Hosp, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 935 DI 10.1158/1538-7445.AM2014-935 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905398 ER PT J AU Thorner, AR Sunkavalli, A Lin, L Jones, RT Schubert, L Ducar, MD Adusumilli, R Dolcen, DN Ziaugra, L Lepine, J MacConaill, LE Hahn, WC Meyerson, M Van Hummelen, P AF Thorner, Aaron R. Sunkavalli, Ashwini Lin, Ling Jones, Robert T. Schubert, Laura Ducar, Matthew D. Adusumilli, Ravali Dolcen, Deniz Nesli Ziaugra, Liuda Lepine, Jack MacConaill, Laura E. Hahn, William C. Meyerson, Matthew Van Hummelen, Paul TI Reducing GC-bias and improving coverage distribution in Illumina sequencing using the Kapa Biosystems library construction method SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Thorner, Aaron R.; Sunkavalli, Ashwini; Lin, Ling; Jones, Robert T.; Schubert, Laura; Ducar, Matthew D.; Adusumilli, Ravali; Dolcen, Deniz Nesli; Ziaugra, Liuda; Lepine, Jack; MacConaill, Laura E.; Hahn, William C.; Meyerson, Matthew; Van Hummelen, Paul] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3583 DI 10.1158/1538-7445.AM2014-3583 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201079 ER PT J AU Thrift, AP Berndt, SI Chan, AT Chang-Claude, J Slattery, ML Cotterchio, M Casey, G Potter, JD Newcomb, PA White, E Brenner, H Peters, U Campbell, PT AF Thrift, Aaron P. Berndt, Sonja I. Chan, Andrew T. Chang-Claude, Jenny Slattery, Martha L. Cotterchio, Michelle Casey, Graham Potter, John D. Newcomb, Polly A. White, Emily Brenner, Hermann Peters, Ulrike Campbell, Peter T. TI Obesity and risk of colorectal cancer: A Mendelian randomization study SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Thrift, Aaron P.; Potter, John D.; Newcomb, Polly A.; White, Emily; Peters, Ulrike] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Berndt, Sonja I.] NCI, Bethesda, MD 20892 USA. [Chan, Andrew T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Chan, Andrew T.] Harvard Univ, Sch Med, Boston, MA USA. [Chang-Claude, Jenny; Brenner, Hermann] German Canc Res Ctr, Heidelberg, Germany. [Slattery, Martha L.] Univ Utah Hlth Sci Ctr, Salt Lake City, UT USA. [Cotterchio, Michelle] Canc Care Ontario, Toronto, ON, Canada. [Casey, Graham] Univ So Calif, Los Angeles, CA USA. [Campbell, Peter T.] Amer Canc Soc, Atlanta, GA 30329 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2176 DI 10.1158/1538-7445.AM2014-2176 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902388 ER PT J AU Ting, DT Wittner, BS Shah, AM Miyamoto, DT Brannigan, BW Xega, K Ciciliano, J MacKenzie, OC Trautwein, J Shahid, M Ellis, HL Qu, N Bardeesy, N Rivera, MN Kapur, R Ramaswamy, S Shioda, T Toner, M Maheswaran, S Haber, DA AF Ting, David T. Wittner, Ben S. Shah, Ajay M. Miyamoto, David T. Brannigan, Brian W. Xega, Kristina Ciciliano, Jordan MacKenzie, Olivia C. Trautwein, Julie Shahid, Mohammad Ellis, Haley L. Qu, Na Bardeesy, Nabeel Rivera, Miguel N. Kapur, Ravi Ramaswamy, Sridhar Shioda, Toshi Toner, Mehmet Maheswaran, Shyamala Haber, Daniel A. TI Diversity of circulating tumor cells in a mouse pancreatic cancer model identified by single cell RNA sequencing SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Ting, David T.; Wittner, Ben S.; Shah, Ajay M.; Miyamoto, David T.; Brannigan, Brian W.; Xega, Kristina; Ciciliano, Jordan; MacKenzie, Olivia C.; Trautwein, Julie; Shahid, Mohammad; Ellis, Haley L.; Qu, Na; Bardeesy, Nabeel; Rivera, Miguel N.; Kapur, Ravi; Ramaswamy, Sridhar; Shioda, Toshi; Toner, Mehmet; Maheswaran, Shyamala; Haber, Daniel A.] Massachusetts Gen Hosp, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA NG04 DI 10.1158/1538-7445.AM2014-NG04 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205437 ER PT J AU Tricker, EM Xu, CX Ercan, D Ogino, A Wong, KK Janne, P AF Tricker, Erin M. Xu, Chunxiao Ercan, Dalia Ogino, Atsuko Wong, Kwok-kin Janne, Pasi TI Combined EGFR and MEK inhibition prevents the emergence of drug resistance in EGFR mutant non-small cell lung cancer (NSCLC) SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Tricker, Erin M.; Xu, Chunxiao; Ercan, Dalia; Ogino, Atsuko; Wong, Kwok-kin; Janne, Pasi] DFCI, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1832 DI 10.1158/1538-7445.AM2014-1832 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906902049 ER PT J AU Tsang, TY Mohapatra, G Itamochi, H Mok, SC Birrer, MJ AF Tsang, Tsun Yee Mohapatra, Gayatry Itamochi, Hiroaki Mok, Samuel C. Birrer, Michael J. TI Identification of FGFR3 as a potential therapeutic target gene for human clear cell ovarian cancer by global genomic analysis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Tsang, Tsun Yee; Mohapatra, Gayatry; Birrer, Michael J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Itamochi, Hiroaki] Tottori Univ Sch Med, Tottori, Japan. [Mok, Samuel C.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1528 DI 10.1158/1538-7445.AM2014-1528 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901254 ER PT J AU Turker, NS Mahmood, U Kucherlapati, MH Kucherlapati, R AF Turker, N. Selcan Mahmood, Umar Kucherlapati, Melani H. Kucherlapati, Raju TI Molecular imaging of colorectal cancer in the setting of colitis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Turker, N. Selcan; Mahmood, Umar] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Kucherlapati, Melani H.; Kucherlapati, Raju] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4926 DI 10.1158/1538-7445.AM2014-4926 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203389 ER PT J AU Ulkus, L Rider, L Nieto, C Romero, L Chen, HT Loda, M Liu, WN Xu, JF Cramer, S AF Ulkus, Lindsey Rider, Leah Nieto, Cera Romero, Lina Chen, Haitao Loda, Massimo Liu, Wennuan Xu, Jianfeng Cramer, Scott TI Coordinate loss of CHD1 and MAP3K7 promotes aggressive prostate cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Ulkus, Lindsey; Liu, Wennuan; Xu, Jianfeng] Wake Forest Univ, Winston Salem, NC 27109 USA. [Rider, Leah; Nieto, Cera; Romero, Lina; Cramer, Scott] Univ Colorado Denver, Aurora, CO USA. [Chen, Haitao] Fudan Univ, Shanghai 200433, Peoples R China. [Loda, Massimo] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 445 DI 10.1158/1538-7445.AM2014-445 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906904410 ER PT J AU Vaid, M Katiyar, SK AF Vaid, Mudit Katiyar, Santosh K. TI Bioactive proanthocyanidins from grape seeds inhibit cigarette smoke condensate-enhanced invasion of human non-small cell lung cancer cells by targeting NADPH oxidase and epithelial-mesenchymal transition SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Vaid, Mudit; Katiyar, Santosh K.] Univ Alabama Birmingham, Birmingham, AL USA. [Katiyar, Santosh K.] Birmingham VA Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1240 DI 10.1158/1538-7445.AM2014-1240 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900478 ER PT J AU Wagle, N Grabiner, BC Van Allen, EM Amin-Mansour, A Carter, SC Gray, N Barletta, JA Swanson, SJ Ruan, D Kwiatkowski, DJ Hanna, GJ Haddad, RI Sabatini, D Janne, PA Garraway, LA Lorch, JH AF Wagle, Nikhil Grabiner, Brian C. Van Allen, Eliezer M. Amin-Mansour, Ali Carter, Scott C. Gray, Nathanael Barletta, Justine A. Swanson, Scott J. Ruan, Daniel Kwiatkowski, David J. Hanna, Glenn J. Haddad, Robert I. Sabatini, David Janne, Pasi A. Garraway, Levi A. Lorch, Jochen H. TI Genomic mechanisms of exquisite sensitivity and acquired resistance to everolimus in a patient with anaplastic thyroid carcinoma SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wagle, Nikhil; Van Allen, Eliezer M.; Gray, Nathanael; Kwiatkowski, David J.; Haddad, Robert I.; Janne, Pasi A.; Garraway, Levi A.; Lorch, Jochen H.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Grabiner, Brian C.; Sabatini, David] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Amin-Mansour, Ali; Carter, Scott C.] Broad Inst, Cambridge, MA USA. [Barletta, Justine A.; Swanson, Scott J.; Ruan, Daniel] Brigham & Womens Hosp, Boston, MA 02115 USA. [Hanna, Glenn J.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1724 DI 10.1158/1538-7445.AM2014-1724 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901446 ER PT J AU Waldron, L Riester, M Birrer, M Parmigiani, G AF Waldron, Levi Riester, Markus Birrer, Michael Parmigiani, Giovanni TI A comparative meta-analysis of prognostic gene signatures for late-stage ovarian cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Waldron, Levi] CUNY, New York, NY 10021 USA. [Riester, Markus; Parmigiani, Giovanni] Dana Farber Canc Inst, Boston, MA 02115 USA. [Birrer, Michael] Partners Hlth Network, Boston, MA USA. OI Waldron, Levi/0000-0003-2725-0694 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 2353 DI 10.1158/1538-7445.AM2014-2353 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906903076 ER PT J AU Walensky, LD AF Walensky, Loren D. TI Dissecting the canonical and noncanonical interactions of the BCL-2 family for therapeutic benefit SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Walensky, Loren D.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA SY37-01 DI 10.1158/1538-7445.AM2014-SY37-01 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205479 ER PT J AU Wang, J Zhang, XH Beck, AH Collins, LC Chen, WD Tamimi, RM Hazra, A Rosner, B Hankinson, SE AF Wang, Jun Zhang, Xuehong Beck, Andrew H. Collins, Laura C. Chen, Wendy Tamimi, Rulla M. Hazra, Aditi Rosner, Bernard Hankinson, Susan E. TI Lifetime alcohol consumption and risk of breast cancer, by tumor androgen receptor expression SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wang, Jun; Hankinson, Susan E.] Univ Massachusetts, Amherst, MA 01003 USA. [Zhang, Xuehong; Chen, Wendy; Tamimi, Rulla M.; Hazra, Aditi; Rosner, Bernard; Hankinson, Susan E.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Zhang, Xuehong; Beck, Andrew H.; Collins, Laura C.; Chen, Wendy; Tamimi, Rulla M.; Hazra, Aditi; Rosner, Bernard; Hankinson, Susan E.] Harvard Univ, Sch Med, Boston, MA USA. [Beck, Andrew H.; Collins, Laura C.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Chen, Wendy] Dana Farber Canc Inst, Boston, MA 02115 USA. [Tamimi, Rulla M.; Hazra, Aditi; Rosner, Bernard; Hankinson, Susan E.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1270 DI 10.1158/1538-7445.AM2014-1270 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901009 ER PT J AU Wang, M Kern, AM Hulskotter, M Greninger, P Singh, A Pan, YF Chowdhury, D Krause, M Baumann, M Benes, CH Efstathiou, JA Settleman, J Willers, H AF Wang, Meng Kern, Ashley M. Huelskoetter, Marieke Greninger, Patricia Singh, Anurag Pan, Yunfeng Chowdhury, Dipanjan Krause, Mechthild Baumann, Michael Benes, Cyril H. Efstathiou, Jason A. Settleman, Jeff Willers, Henning TI Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wang, Meng; Kern, Ashley M.; Huelskoetter, Marieke; Efstathiou, Jason A.; Willers, Henning] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. [Greninger, Patricia; Singh, Anurag; Benes, Cyril H.; Settleman, Jeff] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA. [Pan, Yunfeng; Chowdhury, Dipanjan] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA. [Krause, Mechthild; Baumann, Michael] Tech Univ Dresden, Dept Radiat Oncol, Fac Med, D-01062 Dresden, Germany. [Krause, Mechthild; Baumann, Michael] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, D-01062 Dresden, Germany. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-209 DI 10.1158/1538-7445.AM2014-LB-209 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205243 ER PT J AU Wang, YY Patel, SS Cong, J Zhang, N Qi, Y Sabbatino, F Isakoff, S DeLeo, AB Ferrone, S Wang, XH AF Wang, Yangyang Patel, Shalin S. Cong, Juan Zhang, Nan Qi, Yuan Sabbatino, Francesco Isakoff, Steven DeLeo, Albert B. Ferrone, Soldano Wang, Xinhui TI Combinatorial therapy for triple negative breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wang, Yangyang; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Qi, Yuan; Sabbatino, Francesco; Isakoff, Steven; Ferrone, Soldano; Wang, Xinhui] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [DeLeo, Albert B.] Univ Pittsburgh, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3639 DI 10.1158/1538-7445.AM2014-3639 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201132 ER PT J AU Wang, YX Marino-Enriquez, A Bennett, R Zhu, MJ Eilers, G Antonescu, C Fletche, C Raut, C van de Rijn, M Kunkel, L Demetri, G Fletcher, J AF Wang, Yuexiang Marino-Enriquez, Adrian Bennett, Richard Zhu, Meijun Eilers, Grant Antonescu, Cristina Fletche, Christopher Raut, Chandrajit van de Rijn, Matt Kunkel, Louis Demetri, George Fletcher, Jonathan TI Dystrophin Is a tumor suppressor in human cancers with myogenic programs SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wang, Yuexiang; Marino-Enriquez, Adrian; Zhu, Meijun; Eilers, Grant; Fletche, Christopher; Raut, Chandrajit; Fletcher, Jonathan] Brigham & Womens Hosp, Boston, MA 02115 USA. [Bennett, Richard; Kunkel, Louis] Childrens Hosp Boston, Boston, MA USA. [Antonescu, Cristina] Mem Sloan Kettering Canc Ctr, New York, NY USA. [van de Rijn, Matt] Stanford Univ, Med Ctr, Stanford, CA 94305 USA. [Demetri, George] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1572 DI 10.1158/1538-7445.AM2014-1572 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901297 ER PT J AU Watanabe, H Ma, QP Peng, SY Adelmant, G Swain, D Song, WY Fox, C Francis, JM Pedamallu, CS Deluca, DS Brooks, AN Que, JW Rustgi, AK Wong, KK Ligon, KL Liu, XS Marto, JA Meyerson, M Bass, AJ AF Watanabe, Hideo Ma, Qiuping Peng, Shouyong Adelmant, Guillaume Swain, Danielle Song, Wenyu Fox, Cameron Francis, Joshua M. Pedamallu, Chandra Sekhar Deluca, David S. Brooks, Angela N. Que, Jianwen Rustgi, Anil K. Wong, Kwok-kin Ligon, Keith L. Liu, X. Shirley Marto, Jarrod A. Meyerson, Matthew Bass, Adam J. TI SOX2-p63 interaction and genomic co-localization in squamous cell carcinomas SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Watanabe, Hideo; Ma, Qiuping; Peng, Shouyong; Adelmant, Guillaume; Swain, Danielle; Song, Wenyu; Fox, Cameron; Wong, Kwok-kin; Ligon, Keith L.; Liu, X. Shirley; Marto, Jarrod A.; Meyerson, Matthew; Bass, Adam J.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Francis, Joshua M.; Pedamallu, Chandra Sekhar; Deluca, David S.; Brooks, Angela N.] Broad Inst, Cambridge, MA USA. [Que, Jianwen] Univ Rochester, Rochester, NY USA. [Rustgi, Anil K.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1391 DI 10.1158/1538-7445.AM2014-1391 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901123 ER PT J AU Wayne, AS Shah, NN Bhojwani, D Silverman, LB Whitlock, JA Stetler-Stevenson, M Kreitman, RJ Goswami, T Ibrahim, R Pastan, I AF Wayne, Alan S. Shah, Nirali N. Bhojwani, Deepa Silverman, Lewis B. Whitlock, James A. Stetler-Stevenson, Maryalice Kreitman, Robert J. Goswami, Trishna Ibrahim, Ramy Pastan, Ira TI Pediatric phase 1 trial of moxetumomab pasudotox: Activity in chemotherapy refractory acute lymphoblastic leukemia (ALL) SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wayne, Alan S.] Univ So Calif, Childrens Hosp Los Angeles, Los Angeles, CA USA. [Shah, Nirali N.] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Bhojwani, Deepa] St Jude Childrens Res Hosp, Oncol, Memphis, TN 38105 USA. [Silverman, Lewis B.] Boston Childrens Hosp, Dana Farber Canc Inst, Pediat Oncol, Boston, MA USA. [Whitlock, James A.] Univ Toronto, Hosp Sick Children, Dept Pediat, Hematol Oncol, Toronto, ON M5G 1X8, Canada. [Stetler-Stevenson, Maryalice] NCI, Pathol Lab, CCR, NIH, Bethesda, MD 20892 USA. [Kreitman, Robert J.; Pastan, Ira] NCI, Mol Biol Lab, CCR, NIH, Bethesda, MD 20892 USA. [Goswami, Trishna; Ibrahim, Ramy] MedImmune, Gaithersburg, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT230 DI 10.1158/1538-7445.AM2014-CT230 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205057 ER PT J AU Wilson, MA Zhao, FM Khare, S Letrero, R D'Andrea, K Rimm, DL Kirkwood, JM Kluger, HM Lee, SJ Schuchter, LM Flaherty, KT Nathanson, KL AF Wilson, Melissa A. Zhao, Fengmin Khare, Sanika Letrero, Richard D'Andrea, Kurt Rimm, David L. Kirkwood, John M. Kluger, Harriet M. Lee, Sandra J. Schuchter, Lynn M. Flaherty, Keith T. Nathanson, Katherine L. TI Copy number changes are associated with BRAF and NRAS mutations and response to treatment with carboplatin, paclitaxel and sorafenib SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wilson, Melissa A.; Khare, Sanika; Letrero, Richard; D'Andrea, Kurt; Schuchter, Lynn M.; Nathanson, Katherine L.] Univ Penn, Philadelphia, PA 19104 USA. [Zhao, Fengmin; Lee, Sandra J.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Rimm, David L.; Kluger, Harriet M.] Yale Univ, New Haven, CT USA. [Kirkwood, John M.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Flaherty, Keith T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 933 DI 10.1158/1538-7445.AM2014-933 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905396 ER PT J AU Wilson, TR Savage, H O'Brien, C Sanabria, S Lin, RS Wagle, MC Yan, YB Lackner, MR Parmar, H Hsu, JY Juric, D Krop, IE Ramanathan, RK Von Hoff, DD Baselga, J AF Wilson, Timothy R. Savage, Heidi O'Brien, Carol Sanabria, Sandra Lin, Ray S. Wagle, Marie-Claire Yan, Yibing Lackner, Mark R. Parmar, Hema Hsu, Jerry Y. Juric, Dejan Krop, Ian E. Ramanathan, Ramesh K. Von Hoff, Daniel D. Baselga, Jose TI Expanded biomarker results from a phase I dose escalation study of GDC-0032, a beta isoform-sparing PI3K inhibitor SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wilson, Timothy R.; Savage, Heidi; O'Brien, Carol; Sanabria, Sandra; Lin, Ray S.; Wagle, Marie-Claire; Yan, Yibing; Lackner, Mark R.; Parmar, Hema; Hsu, Jerry Y.] Genentech Inc, San Francisco, CA 94080 USA. [Juric, Dejan] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Krop, Ian E.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Ramanathan, Ramesh K.; Von Hoff, Daniel D.] Virginia G Piper Canc TGen, Scottsdale, AZ USA. [Baselga, Jose] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 915 DI 10.1158/1538-7445.AM2014-915 PG 2 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905376 ER PT J AU Wulf, GM Juvekar, A Lyssiotis, CA Hu, H Yadegarynia, S Liu, H Kim, B Winter, E Scully, R Asara, J Cantley, LC Matulonis, U AF Wulf, Gerburg M. Juvekar, Ashish Lyssiotis, Costas A. Hu, Hai Yadegarynia, Sina Liu, Hui Kim, Baek Winter, Eric Scully, Ralph Asara, John Cantley, Lewis C. Matulonis, Ursula TI Combination of a PI3K-and a PARP-inhibitor to treat high-grade serous ovarian or triple-negative breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Wulf, Gerburg M.; Juvekar, Ashish; Hu, Hai; Yadegarynia, Sina; Liu, Hui; Scully, Ralph; Asara, John] Beth Israel Deaconess Med Ctr, Boston, MA USA. [Lyssiotis, Costas A.; Cantley, Lewis C.] Weill Cornell Med Sch, New York, NY USA. [Kim, Baek] Emory Sch Med, Atlanta, GA USA. [Winter, Eric; Matulonis, Ursula] Dana Farber Canc Inst, Boston, MA 02115 USA. RI Cantley, Lewis/D-1800-2014 OI Cantley, Lewis/0000-0002-1298-7653 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA CT338 DI 10.1158/1538-7445.AM2014-CT338 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205102 ER PT J AU Yang, XQ Lyer, A Hornicek, F Amiji, M Duan, ZF AF Yang, Xiaoqian Lyer, Arun Hornicek, Francis Amiji, Mansoor Duan, Zhenfeng TI Hyaluronic acid-based CD44 targeted nanoparticle delivery of combination MDR1 siRNA/paclitaxel to overcome drug resistance in ovarian cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Yang, Xiaoqian; Hornicek, Francis; Duan, Zhenfeng] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Lyer, Arun; Amiji, Mansoor] Northeastern Univ, Boston, MA USA. NR 0 TC 0 Z9 0 U1 3 U2 8 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA LB-13 DI 10.1158/1538-7445.AM2014-LB-13 PG 1 WC Oncology SC Oncology GA CB8VR UT WOS:000349910205163 ER PT J AU Yang, XQ Hornicek, F Duan, ZF AF Yang, Xiaoqian Hornicek, Francis Duan, Zhenfeng TI Prevention and reversion of multidrug resistance (MDR) in cancer by NSC23925 SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Yang, Xiaoqian; Hornicek, Francis; Duan, Zhenfeng] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 762 DI 10.1158/1538-7445.AM2014-762 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905222 ER PT J AU Yoon, C Park, DJ Schmidt, B Thomas, NJ Lee, HJ Kim, TS Janjigian, YY Cohen, DJ Yoon, SS AF Yoon, Changhwan Park, Do Joong Schmidt, Benjamin Thomas, Nicholas J. Lee, Hae-June Kim, Teresa S. Janjigian, Yelena Y. Cohen, Deirdre J. Yoon, Sam S. TI Hedgehog signaling maintains gastric cancer stem cells and promotes chemotherapy resistance: results from laboratory and clinical studies SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Yoon, Changhwan; Park, Do Joong; Thomas, Nicholas J.; Kim, Teresa S.; Janjigian, Yelena Y.; Yoon, Sam S.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Schmidt, Benjamin] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Lee, Hae-June] Korea Inst Radiol & Med Sci, Seoul, South Korea. [Cohen, Deirdre J.] NYU, Med Ctr, New York, NY 10016 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 3873 DI 10.1158/1538-7445.AM2014-3873 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910201361 ER PT J AU Young, MR Noble, PW Weisbart, RH Hansen, JE AF Young, Melissa R. Noble, Philip W. Weisbart, Richard H. Hansen, James E. TI Targeting K-ras mutant cancer cells with a lupus anti-guanosine antibody SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Young, Melissa R.; Noble, Philip W.; Hansen, James E.] Yale Univ Sch Med, New Haven, CT USA. [Weisbart, Richard H.] Vet Affairs Greater Los Angeles Hlth Care Syst, Sepulveda, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 654 DI 10.1158/1538-7445.AM2014-654 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905116 ER PT J AU Yuzugullu, H Baitsch, L Steiner, A Clayton, LK Gritsman, K Zhao, JJ AF Yuzugullu, Haluk Baitsch, Lukas Steiner, Allison Clayton, Linda K. Gritsman, Kira Zhao, Jean J. TI PI3K-p110 beta is required for leukemic transformation and HSC depletion in the absence of Pten SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Yuzugullu, Haluk; Baitsch, Lukas; Steiner, Allison; Clayton, Linda K.; Gritsman, Kira; Zhao, Jean J.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4775 DI 10.1158/1538-7445.AM2014-4775 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203246 ER PT J AU Zhang, XL Yang, G Look, AT Neel, BG Zhu, SZ AF Zhang, Xiaoling Yang, Guang Look, A. Thomas Neel, Benjamin G. Zhu, Shizhen (Jane) TI Activated SHP2 collaborates with MYCN in neuroblastoma tumorigenesis SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Zhang, Xiaoling; Yang, Guang; Zhu, Shizhen (Jane)] Mayo Clin, Rochester, MN USA. [Look, A. Thomas] Dana Farber Canc Inst, Boston, MA 02115 USA. [Neel, Benjamin G.] Ontario Canc Inst, Toronto, ON M4X 1K9, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 80 DI 10.1158/1538-7445.AM2014-80 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900079 ER PT J AU Zhao, DK Besser, AH Zhou, W Wander, SA Sun, J Durante, M Hong, F Wang, B Ince, T Briegel, K Slingerland, JM AF Zhao, Dekuang Besser, Alexandra H. Zhou, Wen Wander, Seth A. Sun, Jun Durante, Michael Hong, Feng Wang, Bin Ince, Tan Briegel, Karoline Slingerland, Joyce M. TI Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor progression via Twist1 upregulation SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Zhao, Dekuang; Besser, Alexandra H.; Zhou, Wen; Sun, Jun; Durante, Michael; Hong, Feng; Wang, Bin; Ince, Tan; Briegel, Karoline; Slingerland, Joyce M.] Univ Miami Miller Sch Med, Miami, FL USA. [Wander, Seth A.] Harvard Univ, Sch Med, Dept Med, Massachusetts Gen Hosp, Boston, MA USA. RI Zhou, Wen/A-5763-2010 OI Zhou, Wen/0000-0002-5496-5815 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1145 DI 10.1158/1538-7445.AM2014-1145 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906900382 ER PT J AU Zhou, HY Vargas, LT Elliot, J Mathisen, DJ Lanuti, M AF Zhou, Haiyu Vargas, Luis Tapias Elliot, Justin Mathisen, Douglas J. Lanuti, Michael TI Identification of driver mutations and gene amplifications in resected asophageal adenocarcinoma: Impact on clinical care SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Zhou, Haiyu; Vargas, Luis Tapias; Elliot, Justin; Mathisen, Douglas J.; Lanuti, Michael] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 4696 DI 10.1158/1538-7445.AM2014-4696 PG 2 WC Oncology SC Oncology GA CB8VR UT WOS:000349910203169 ER PT J AU Penson, RT Huang, HQ Wenzel, L Tewari, K Monk, BJ Sill, M Stockman, S Ramondetta, L Landrum, L Oaknin, A Reid, T Leitao, M AF Penson, Richard T. Huang, Helen Q. Wenzel, Lari Tewari, Krishnansu Monk, Bradley J. Sill, Michael Stockman, Sharon Ramondetta, Lois Landrum, Lisa Oaknin, Ana Reid, Thomas Leitao, Mario TI Patient-Reported Outcomes in a Randomized Trial of Bevacizumab in the Treatment of Advanced Cervical Cancer: a Gynecologic Oncology Group Study SO QUALITY OF LIFE RESEARCH LA English DT Meeting Abstract C1 [Penson, Richard T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Huang, Helen Q.; Sill, Michael] GOG Stat & Data Ctr, Buffalo, NY USA. [Wenzel, Lari; Tewari, Krishnansu] Univ Calif Irvine, Irvine, CA USA. [Monk, Bradley J.] St Josephs Hosp, Denver, CO USA. [Stockman, Sharon] Univ Iowa, Iowa City, IA 52242 USA. [Ramondetta, Lois] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Landrum, Lisa] Univ Oklahoma, Hlth Sci Ctr, Norman, OK 73019 USA. [Oaknin, Ana] GEICO Barcelona, Barcelona, Spain. [Reid, Thomas] Kettering Med Ctr, Dayton, OH USA. [Leitao, Mario] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0962-9343 EI 1573-2649 J9 QUAL LIFE RES JI Qual. Life Res. PD OCT PY 2014 VL 23 SU 1 MA 1011 BP 68 EP 68 PG 1 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CF6XJ UT WOS:000352699800170 ER PT J AU Singh, JA Khanna, P Aquino-Beaton, C Persselin, JE Duffy, E Elashoff, D Khanna, D AF Singh, Jasvinder A. Khanna, Puja Aquino-Beaton, Cleopatra Persselin, Jay E. Duffy, Erin Elashoff, David Khanna, Dinesh TI Racial Differences in Quality of Life in Patients with Gout SO QUALITY OF LIFE RESEARCH LA English DT Meeting Abstract C1 [Singh, Jasvinder A.] Univ Alabama Birmingham, Birmingham, AL USA. [Khanna, Puja] Univ Michigan, Ann Arbor, MI 48109 USA. [Aquino-Beaton, Cleopatra; Persselin, Jay E.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Duffy, Erin; Elashoff, David] Univ Calif Los Angeles, Los Angeles, CA USA. [Khanna, Dinesh] Univ Cincinnati, Cincinnati, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0962-9343 EI 1573-2649 J9 QUAL LIFE RES JI Qual. Life Res. PD OCT PY 2014 VL 23 SU 1 MA 2025 BP 107 EP 107 PG 1 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CF6XJ UT WOS:000352699800275 ER PT J AU Marino, ME Bori, MS Rossi, M Amaya, F Slavin, MD Jette, A Ryan, C Acton, A Schneider, J Kazis, LE AF Marino, Molly E. Bori, Marina Soley Rossi, Melinda Amaya, Flor Slavin, Mary D. Jette, Alan Ryan, Colleen Acton, Amy Schneider, Jeffrey Kazis, Lewis E. TI Measuring the community Re-Integration of burn injuries in adults: conceptual foundation for future development of a computer adaptive test (CAT) SO QUALITY OF LIFE RESEARCH LA English DT Meeting Abstract C1 [Marino, Molly E.; Bori, Marina Soley; Rossi, Melinda; Amaya, Flor; Slavin, Mary D.; Jette, Alan] Boston Univ, Boston, MA 02215 USA. [Ryan, Colleen; Schneider, Jeffrey] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Acton, Amy] Phoenix Soc Burn Survivors, Phoenix, AZ USA. [Kazis, Lewis E.] Ctr Assessment Pharmaceut Practices, Boston, MA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0962-9343 EI 1573-2649 J9 QUAL LIFE RES JI Qual. Life Res. PD OCT PY 2014 VL 23 SU 1 MA 2102 BP 141 EP 141 PG 1 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CF6XJ UT WOS:000352699800361 ER PT J AU Kuhlthau, KA McDonnell, E Coury, D Macklin, E AF Kuhlthau, Karen A. McDonnell, Erin Coury, Daniel Macklin, Eric TI Correlates of cross-sectional and longitudinal health-related quality of life among children with autism spectrum disorders SO QUALITY OF LIFE RESEARCH LA English DT Meeting Abstract C1 [Kuhlthau, Karen A.] Ctr Child & Adolescent Hlth Res & Policy, Boston, MA USA. [McDonnell, Erin; Macklin, Eric] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Coury, Daniel] Nationwide Childrens Hosp, Columbus, OH USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0962-9343 EI 1573-2649 J9 QUAL LIFE RES JI Qual. Life Res. PD OCT PY 2014 VL 23 SU 1 MA 3044 BP 170 EP 170 PG 1 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CF6XJ UT WOS:000352699800428 ER PT J AU D'Aiuto, L Zhi, Y Das, DK Wilcox, MR Johnson, JW McClain, L MacDonald, ML Di Maio, R Schurdak, ME Piazza, P Viggiano, L Sweet, R Kinchington, PR Bhattacharjee, AG Yolken, R Nimgaonka, VL AF D'Aiuto, Leonardo Zhi, Yun Das, Dhanjit Kumar Wilcox, Madeleine R. Johnson, Jon W. McClain, Lora MacDonald, Matthew L. Di Maio, Roberto Schurdak, Mark E. Piazza, Paolo Viggiano, Luigi Sweet, Robert Kinchington, Paul R. Bhattacharjee, Ayantika G. Yolken, Robert Nimgaonka, Vishwajit L. TI Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation SO ORGANOGENESIS LA English DT Article DE high-throughput screening; induced pluripotent stem cells (iPSCs); neural progenitor cells; neural stem cells; neuronal differentiation ID IN-VITRO DIFFERENTIATION; CORTICAL-NEURONS; DISEASE; PROGRESSION; MODULATION; PROTEIN; SOX1 AB Induced pluripotent stem cell (iPSC)-based technologies offer an unprecedented opportunity to perform high-throughput screening of novel drugs for neurological and neurodegenerative diseases. Such screenings require a robust and scalable method for generating large numbers of mature, differentiated neuronal cells. Currently available methods based on differentiation of embryoid bodies (EBs) or directed differentiation of adherent culture systems are either expensive or are not scalable. We developed a protocol for large-scale generation of neuronal stem cells (NSCs)/early neural progenitor cells (eNPCs) and their differentiation into neurons. Our scalable protocol allows robust and cost-effective generation of NSCs/eNPCs from iPSCs. Following culture in neurobasal medium supplemented with B27 and BDNF, NSCs/eNPCs differentiate predominantly into vesicular glutamate transporter 1 (VGLUT1) positive neurons. Targeted mass spectrometry analysis demonstrates that iPSC-derived neurons express ligand-gated channels and other synaptic proteins and whole-cell patch-clamp experiments indicate that these channels are functional. The robust and cost-effective differentiation protocol described here for large-scale generation of NSCs/eNPCs and their differentiation into neurons paves the way for automated high-throughput screening of drugs for neurological and neurodegenerative diseases. C1 [D'Aiuto, Leonardo; Zhi, Yun; Das, Dhanjit Kumar; McClain, Lora; MacDonald, Matthew L.; Sweet, Robert; Bhattacharjee, Ayantika G.; Nimgaonka, Vishwajit L.] Univ Pittsburgh, Sch Med, Dept Psychiat, Western Psychiat Inst & Clin, Pittsburgh, PA 15260 USA. [Zhi, Yun] Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China. [Das, Dhanjit Kumar] Natl Inst Res Reprod Hlth, Genet Res Ctr, Bombay, Maharashtra, India. [Wilcox, Madeleine R.; Johnson, Jon W.] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA USA. [Wilcox, Madeleine R.; Johnson, Jon W.] Univ Pittsburgh, Ctr Neurosci, Pittsburgh, PA 15260 USA. [McClain, Lora; Nimgaonka, Vishwajit L.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA. [Di Maio, Roberto] Univ Pittsburgh, Pittsburgh Inst Neurodegenerat Dis, Pittsburgh, PA USA. [Di Maio, Roberto] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA. [Di Maio, Roberto] Ri MED Fdn, Palermo, Italy. [Schurdak, Mark E.] Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA USA. [Piazza, Paolo] Univ Pittsburgh, Dept Infect Dis & Microbiol, Pittsburgh, PA 15260 USA. [Viggiano, Luigi] Univ Bari Aldo Moro, Dept Biol, Bari, Italy. [Sweet, Robert] VA Pittsburgh Healthcare Syst, Mental Illness Res Educ & Clin Ctr, Pittsburgh, PA USA. [Kinchington, Paul R.] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Pittsburgh, PA 15261 USA. [Kinchington, Paul R.] Univ Pittsburgh, Dept Mol Genet & Biochem, Pittsburgh, PA USA. [Yolken, Robert] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Neurovirol, Baltimore, MD 21205 USA. RP Nimgaonka, VL (reprint author), Univ Pittsburgh, Sch Med, Dept Psychiat, Western Psychiat Inst & Clin, Pittsburgh, PA 15260 USA. EM VishwajitNL@upmc.edu RI Di Maio, Roberto/G-1788-2015 FU NIH [MH63480, MH045817, MH071533]; Stanley Medical Research Foundation [07R-1712]; Ri.MED; China Scholarship Council; Indo-US Science & Technology Forum (IUSSTF); [P30CA047904] FX This project was funded from NIH grants MH63480 and MH045817, and MH071533, by Stanley Medical Research Foundation 07R-1712, and by the Ri.MED. We also thank China Scholarship Council for providing a fellowship to YZ and thank Indo-US Science & Technology Forum (IUSSTF) for providing a fellowship to DKD. The Biomedical Mass Spectrometry Center and UPCI Cancer Biomarker Facility are supported in part by award P30CA047904. NR 33 TC 6 Z9 6 U1 3 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1547-6278 EI 1555-8592 J9 ORGANOGENESIS JI Organogenesis PD OCT-DEC PY 2014 VL 10 IS 4 BP 365 EP 377 DI 10.1080/15476278.2015.1011921 PG 13 WC Biochemistry & Molecular Biology; Developmental Biology; Engineering, Biomedical SC Biochemistry & Molecular Biology; Developmental Biology; Engineering GA CF5QI UT WOS:000352611600004 PM 25629202 ER PT J AU Epstein, AM Jha, AK Orav, EJ AF Epstein, Arnold M. Jha, Ashish K. Orav, E. John TI The Impact of Pay-for-Performance on Quality of Care for Minority Patients SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID ADMINISTRATIVE DATA; HEALTH-CARE; HOSPITALS; DISPARITIES; IMPROVEMENT; MORTALITY AB Objectives To determine whether racial disparities in process quality and outcomes of care change under hospital pay-for-performance. Study Design Retrospective cohort study comparing the change in racial disparities in process quality and outcomes of care between 2004 and 2008 in hospitals participating in the Premier Hospital Quality Incentive Demonstration versus control hospitals. Methods Using patient-level Hospital Quality Alliance (HQA) data, we identified 226,096 patients in Premier hospitals, which were subject to pay-for-performance (P4P) contracts and 1,607,575 patients at control hospitals who had process of care measured during hospitalization for acute myocardial infarction (AMI), congestive heart failure (CHF), or pneumonia. We additionally identified 123,241 Medicare patients in Premier hospitals and 995,107 in controls who were hospitalized for AMI, CHF, pneumonia, or coronary artery bypass graft (CABG) surgery. We then compared HQA process quality indicators for AMI, CHF, and pneumonia between P4P and control hospitals, as well as risk-adjusted mortality rates for AMI, CHF, pneumonia, and CABG. Results Black patients initially had lower performance on process quality indicators in both Premier and non-Premier hospitals. The racial gap decreased over time in both groups; the reduction in the gap in Premier hospitals was greater than the gap reduction in non-Premier hospitals for AMI patients. During the study period, mortality generally decreased for blacks relative to whites for AMI, CHF, and pneumonia in both Premier and non-Premier hospitals, with the relative reduction for blacks greatest in Premier hospitals for CHF. Conclusions Our results show no evidence of a deleterious impact of P4P in the Premier HQID on racial disparities in process quality or outcomes. C1 [Epstein, Arnold M.; Jha, Ashish K.; Orav, E. John] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Boston, MA 02115 USA. [Epstein, Arnold M.; Jha, Ashish K.; Orav, E. John] Brigham & Womens Hosp, Div Gen Med, Boston, MA 02115 USA. [Jha, Ashish K.] VA Boston Healthcare Syst, Boston, MA USA. RP Epstein, AM (reprint author), Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, 677 Huntington Ave, Boston, MA 02115 USA. EM aepstein@hsph.harvard.edu FU Robert Wood Johnson Foundation, Princeton, NJ FX This study was funded by the Robert Wood Johnson Foundation, Princeton, NJ. The funding organization did not have any role in the collection, analysis, or interpretation of data, and did not have authority to approve or disapprove publication of the final manuscript. NR 15 TC 0 Z9 0 U1 0 U2 3 PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC PI PLAINSBORO PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD OCT PY 2014 VL 20 IS 10 BP E479 EP + PG 11 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CD3QX UT WOS:000350995900007 PM 25414986 ER PT J AU Singh, H McGregor, JC Nigro, SJ Higginson, A Larsen, GC AF Singh, Harleen McGregor, Jessina C. Nigro, Sarah J. Higginson, Amy Larsen, Greg C. TI Evaluation of Collaborative Therapy Review to Improve Care of Heart Failure Patients SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID CARDIOLOGY PRACTICES; ADULTS; HF; MANAGEMENT; DISEASE; TRIAL AB Objectives As more demands are placed on primary care providers, new innovative models are required to optimize heart failure (HF) care. The purpose of this study was to evaluate a collaborative therapy review (CTR) program that was implemented to improve guideline-based therapy among HF outpatients. Study Design and Methods We screened patient lists of 18 PCPs at the Portland Veterans Affairs Medical Center to identify patients with an ICD-9 code for HF. The charts of patients with ejection fractions (EFs) <40% were then abstracted in more detail. The CTR team reviewed each patient and provided specific guideline-based recommendations. The team then gave specific recommendations to providers through the electronic medical record system. We categorized recommendations relating to drug or device therapies, or need for laboratory testing, and calculated provider acceptance rates by recommendation type. Results Of the 641 patients reviewed, 156 patients had detailed chart reviews. We found opportunities for improvement in care in 70 (45%) patients who received 100 recommendations. Among the 100 recommendations, 62 (55%) were for guideline-based drugs, 12 (17%) were for consideration of device therapy, and 26 (24%) were to update lab tests or echocardiograms. Eighty percent of the recommendations were acted on within 90 days. Conclusions The CTR program was able to facilitate guideline-based management for HF patients by identifying treatment gaps and making specific guideline-based recommendations to PCPs. While further evaluations are needed, this approach may serve as an efficient method of leveraging the expertise of specialty-trained clinicians to optimize patient care. C1 [Singh, Harleen; McGregor, Jessina C.; Nigro, Sarah J.; Higginson, Amy] Oregon Hlth & Sci Univ, Oregon State Univ, Coll Pharm, Portland, OR 97239 USA. [Larsen, Greg C.] Portland VA Med Ctr, Portland, OR USA. RP Singh, H (reprint author), Oregon Hlth & Sci Univ, Oregon State Univ, Coll Pharm, 3303 SW Bond Ave,CH12C, Portland, OR 97239 USA. EM singhh@ohsu.edu NR 17 TC 0 Z9 0 U1 0 U2 2 PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC PI PLAINSBORO PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD OCT PY 2014 VL 20 IS 10 BP E425 EP + PG 10 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CD3QX UT WOS:000350995900001 PM 25414980 ER PT J AU Koofhethile, CK Ndlhovu, Z Ismail, N Mncube, Z Maphumulo, L van de Stok, M Thobakgale, C Prado, JG Walker, BBD Goulder, PJR Ndung'u, T AF Koofhethile, Catherine K. Ndlhovu, Zaza Ismail, Nasreen Mncube, Zanele Maphumulo, Lungi van de Stok, Mary Thobakgale, Christina Prado, Julia G. Walker, Bruce B. D. Goulder, Phillip J. R. Ndung'u, Thumbi TI Reduction in Breadth and Not Polyfunctionality or Proliferative Capacity of CD8+T Cells Is Associated with Loss of Virologic HIV Control SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Koofhethile, Catherine K.; Ndlhovu, Zaza; Ismail, Nasreen; Mncube, Zanele; Maphumulo, Lungi; van de Stok, Mary; Thobakgale, Christina; Walker, Bruce B. D.; Goulder, Phillip J. R.; Ndung'u, Thumbi] Univ KwaZulu Natal, HIV Pathogenesis Programme, Durban, South Africa. [Ndlhovu, Zaza; Walker, Bruce B. D.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ragon Inst, Boston, MA USA. [Prado, Julia G.] Hosp Badalona Germans Trias & Pujol, AIDS Res Inst IrsiCaixa, Barcelona, Spain. [Goulder, Phillip J. R.] Univ Oxford, Dept Paediat, Oxford, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA29.03 BP A75 EP A75 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400169 ER PT J AU Wydra, D Ghamande, S Gabrail, N Nowara, E Bidzinski, M DePasguale, S Clark, R Penson, RT AF Wydra, D. Ghamande, S. Gabrail, N. Nowara, E. Bidzinski, M. DePasguale, S. Clark, R. Penson, R. T. TI Vintafolide and its Companion Imaging Agent, Etarfolatide - Results From a PRECEDENT Subanalysis. SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING LA English DT Meeting Abstract CT Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) CY OCT 18-22, 2014 CL Gothenburg, SWEDEN SP European Assoc Nucl Med C1 [Wydra, D.] Med Univ Gdansk, Dept Gynecol Gynecol Oncol & Gynecol Endocrinol, Gdansk, Poland. [Ghamande, S.] Georgia Hlth Sci Univ, Augusta, GA USA. [Gabrail, N.] Gabrail Canc Ctr, Canton, OH USA. [Nowara, E.] Ctr Canc, Gliwice, Poland. [Nowara, E.] Inst Gliwice Branch, Gliwice, Poland. [Bidzinski, M.] Specialist Hosp Inflancka, Dept Gynecol Oncol, Warsaw, Poland. [DePasguale, S.] Chattanoogas Program Womens Oncol, Chattanooga, TN USA. [Clark, R.] Endocyte Inc, W Lafayette, IN USA. [Penson, R. T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1619-7070 EI 1619-7089 J9 EUR J NUCL MED MOL I JI Eur. J. Nucl. Med. Mol. Imaging PD OCT PY 2014 VL 41 SU 2 MA PW121 BP S353 EP S354 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CA3YT UT WOS:000348841900635 ER PT J AU Sargoy, A Barnes, S Brecha, NC Muller, LPD AF Sargoy, Allison Barnes, Steven Brecha, Nicholas C. Mueller, Luis Perez De Sevilla TI Immunohistochemical and Calcium Imaging Methods in Wholemount Rat Retina SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Neuroscience; Issue 92; immunohistochemistry; antibody; fluo-4; calcium imaging; ganglion cells; retina; rat ID FLUORESCENT PROTEIN EXPRESSION; GANGLION-CELL LAYER; MOUSE RETINA; AMACRINE CELLS; MAMMALIAN RETINA; DIVALENT-CATIONS; CENTRAL NEURONS; MECHANISMS; RECEPTORS; RESPONSES AB In this paper we describe the tools, reagents, and the practical steps that are needed for: 1) successful preparation of wholemount retinas for immunohistochemistry and, 2) calcium imaging for the study of voltage gated calcium channel (VGCC) mediated calcium signaling in retinal ganglion cells. The calcium imaging method we describe circumvents issues concerning non-specific loading of displaced amacrine cells in the ganglion cell layer. C1 [Sargoy, Allison; Barnes, Steven; Brecha, Nicholas C.; Mueller, Luis Perez De Sevilla] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90024 USA. [Barnes, Steven; Brecha, Nicholas C.] Vet Adm Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Barnes, Steven] Dalhousie Univ, Dept Phys & Biophys, Halifax, NS B3H 3J5, Canada. [Barnes, Steven] Dalhousie Univ, Dept Ophthalmol & Visual Sci, Halifax, NS B3H 3J5, Canada. [Brecha, Nicholas C.] Univ Calif Los Angeles, Dept Neurobiol, CURE Digest Dis Res Ctr, Jules Stein Eye Inst,David Geffen Sch Med,Dept Me, Los Angeles, CA USA. RP Muller, LPD (reprint author), Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90024 USA. EM luisperez@mednet.ucla.edu FU U.S. Army Medical Research & Materiel Command (USAMRMC); Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD [W81XWH-10-2-0077]; NIH [EY04067]; VA Merit Review FX We thank Dr. S. Stella and Helen Vuong for contributions to the calcium imaging protocol. We thank Dr. K. Sheets for filming the interview scenes. We thank Dr. Arlene Hirano for her comments on the manuscript. This research and development project was conducted by the authors at the David Geffen School of Medicine at UCLA and is made possible by a contract agreement that was awarded and administered by the U.S. Army Medical Research & Materiel Command (USAMRMC) and the Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD under Contract Number: W81XWH-10-2-0077. Support for these studies also came from NIH EY04067 and a VA Merit Review (NB). NCB is a VA Career Research Scientist. NR 38 TC 2 Z9 2 U1 0 U2 1 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD OCT PY 2014 IS 92 AR e51396 DI 10.3791/51396 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB0GF UT WOS:000349303100006 PM 25349920 ER PT J AU Zhang, XL Kuo, C Moore, A Ran, CZ AF Zhang, Xueli Kuo, Chaincy Moore, Anna Ran, Chongzhao TI Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Medicine; Issue 92; Cerenkov luminescence imaging; brown adipose tissue; 18F-FDG; optical imaging; in vivo imaging; spectral unmixing ID POSITRON-EMITTING RADIOTRACERS; ADULT HUMANS; FAT; THERMOGENESIS; ADIPOGENESIS; TOMOGRAPHY; F-18-FDG; GLUCOSE; OBESITY AB Brown adipose tissue (BAT), widely known as a "good fat" plays pivotal roles for thermogenesis in mammals. This special tissue is closely related to metabolism and energy expenditure, and its dysfunction is one important contributor for obesity and diabetes. Contrary to previous belief, recent PET/CT imaging studies indicated the BAT depots are still present in human adults. PET imaging clearly shows that BAT has considerably high uptake of F-18-FDG under certain conditions. In this video report, we demonstrate that Cerenkov luminescence imaging (CLI) with F-18-FDG can be used to optically image BAT in small animals. BAT activation is observed after intraperitoneal injection of norepinephrine (NE) and cold treatment, and depression of BAT is induced by long anesthesia. Using multiple-filter Cerenkov luminescence imaging, spectral unmixing and 3D imaging reconstruction are demonstrated. Our results suggest that CLI with 18F-FDG is a practical technique for imaging BAT in small animals, and this technique can be used as a cheap, fast, and alternative imaging tool for BAT research. C1 [Zhang, Xueli; Moore, Anna; Ran, Chongzhao] Harvard Univ, Massachusetts Gen Hosp, MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, Mol Imaging Lab,Dept Radiol,Med Sch, Cambridge, MA 02138 USA. [Zhang, Xueli] China Pharmaceut Univ, Sch Pharm, Ctr Drug Discovery, Nanjing, Jiangsu, Peoples R China. [Kuo, Chaincy] Perkin Elmer, Waltham, MA USA. RP Ran, CZ (reprint author), Harvard Univ, Massachusetts Gen Hosp, MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, Mol Imaging Lab,Dept Radiol,Med Sch, Cambridge, MA 02138 USA. EM cran@nmr.mgh.harvard.edu RI Kuo, Chaincy/G-2403-2015; Kuo, Chaincy/H-9475-2016 OI Kuo, Chaincy/0000-0001-7958-8764 FU Perkin Elmer Company FX The authors thank Perkin Elmer Company for supporting this publication. We also thank Alana Ross, B.S. for proofreading this manuscript. NR 44 TC 0 Z9 0 U1 2 U2 11 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD OCT PY 2014 IS 92 AR e51790 DI 10.3791/51790 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB0GF UT WOS:000349303100018 PM 25349986 ER PT J AU Boronat, S Caruso, P Auladell, M Van Eeghen, A Thiele, EA AF Boronat, Susana Caruso, Paul Auladell, Maria Van Eeghen, Agnies Thiele, Elizabeth Anne TI Arachnoid cysts in tuberous sclerosis complex SO BRAIN & DEVELOPMENT LA English DT Article DE Arachnoid cyst; Meninges; Neural crest; Tuberous sclerosis complex (TSC) ID NEURAL CREST AB Objective: Some clinical findings in tuberous sclerosis complex (TSC), such as hypomelanotic macules or angiofibromas are related to problems in development of the neural crest, which is also the origin of cranial leptomeninges. Arachnoid cysts have been reported in two TSC patients to date. The purpose of this study was to assess the prevalence and characteristics of arachnoid cysts in a large cohort of TSC. Materials and method: We performed a review of brain MRIs of 220 TSC patients searching for arachnoid cysts. Results: Arachnoid cysts were found in 12 (5.5%) (general population: 0.5%), including ten males (83.3%). Four patients (33.3%) had also autosomal dominant polycystic kidney disease (ADPKD) due to a contiguous deletion of the TSC2-PKD1 genes. Three patients (25%) had two or more arachnoid cysts, of whom two also had ADPKD. One patient with an arachnoid cyst did not have tubers, subependymal nodules or white matter migration lines. Conclusion: Our study suggests that arachnoid cysts are part of the clinical spectrum of TSC and may be also present in TSC patients without other typical TSC brain lesions. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. C1 [Boronat, Susana; Auladell, Maria; Van Eeghen, Agnies; Thiele, Elizabeth Anne] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Caruso, Paul] Massachusetts Gen Hosp, Dept Neuroradiol, Boston, MA 02114 USA. [Boronat, Susana] Univ Autonoma Barcelona, Vail Hebron Hosp, Dept Pediat Neurol, Barcelona, Spain. RP Thiele, EA (reprint author), Massachusetts Gen Hosp, Pediat Epilepsy Program, 175 Cambridge St,Suite 340, Boston, MA 02114 USA. EM ethiele@partners.org NR 18 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0387-7604 EI 1872-7131 J9 BRAIN DEV-JPN JI Brain Dev. PD OCT PY 2014 VL 36 IS 9 BP 801 EP 806 DI 10.1016/j.braindev.2013.11.003 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA CB2AQ UT WOS:000349429500009 PM 24325802 ER PT J AU Cassani, B Rigoni, R Maina, V Marrella, V Pesole, G Vezzoni, P Grassi, F Mora, JR Villa, A AF Cassani, B. Rigoni, R. Maina, V. Marrella, V. Pesole, G. Vezzoni, P. Grassi, F. Mora, J. R. Villa, A. TI Mucosal Immune Dysregulation in Omenn Syndrome SO JOURNAL OF CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies CY OCT 29-NOV 01, 2014 CL Prague, CZECH REPUBLIC SP European Soc Immunodeficiencies C1 [Cassani, B.; Marrella, V.; Vezzoni, P.; Villa, A.] CNR, IRGB, I-20133 Milan, Italy. [Rigoni, R.; Grassi, F.] Univ Milan, Dipartimento Biol & Genet Sci Med, Milan, Italy. [Maina, V.] Humanitas Clin & Res Ctr, Dept Human Genome, Milan, Italy. [Pesole, G.] Univ Bari, Dipartiment Biosci Biotecnol & Biofarmaceut, Bari, Italy. [Mora, J. R.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Gastrointestinal Unit, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0271-9142 EI 1573-2592 J9 J CLIN IMMUNOL JI J. Clin. Immunol. PD OCT PY 2014 VL 34 SU 2 MA ESID-0104 BP S143 EP S143 PG 1 WC Immunology SC Immunology GA AY1ZS UT WOS:000347389100008 ER PT J AU Massaad, M Tsuchimoto, D Chou, J Ohsumi, T Zhou, J Jabara, H Kane, J Schmitz, K Torisu, K Nakabeppu, Y Kang, P Choueiry, E Megarbane, A Mizui, M Kyriacos, M Tsokos, G El-Herz, W Notarangelo, L Wallace, S Geha, R AF Massaad, M. Tsuchimoto, D. Chou, J. Ohsumi, T. Zhou, J. Jabara, H. Kane, J. Schmitz, K. Torisu, K. Nakabeppu, Y. Kang, P. Choueiry, E. Megarbane, A. Mizui, M. Kyriacos, M. Tsokos, G. El-Herz, W. Notarangelo, L. Wallace, S. Geha, R. TI The Human Nei Endonuclease VIII-Like 3 (NEIL3) is a Novel Gene Associated with the Development of Auto-Antibodies SO JOURNAL OF CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 16th Biennial Meeting of the European-Society-for-Immunodeficiencies CY OCT 29-NOV 01, 2014 CL Prague, CZECH REPUBLIC SP European Soc Immunodeficiencies C1 [Massaad, M.; Chou, J.; Jabara, H.; Kane, J.; Schmitz, K.; Kang, P.; Kyriacos, M.; Notarangelo, L.; Geha, R.] Boston Childrens Hosp, Boston, MA USA. [Tsuchimoto, D.; Torisu, K.; Nakabeppu, Y.] Kyushu Univ, Fukuoka 812, Japan. [Ohsumi, T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Zhou, J.; Wallace, S.] Univ Vermont, Burlington, VT 05405 USA. [Choueiry, E.; Megarbane, A.] Univ St Joseph, Beirut, Lebanon. [Mizui, M.; Tsokos, G.] Harvard Univ, Sch Med, Boston, MA USA. [El-Herz, W.] Kuwait Univ, Kuwait, Kuwait. RI Notarangelo, Luigi/F-9718-2016; Nakabeppu, Yusaku/A-8902-2011 OI Notarangelo, Luigi/0000-0002-8335-0262; NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0271-9142 EI 1573-2592 J9 J CLIN IMMUNOL JI J. Clin. Immunol. PD OCT PY 2014 VL 34 SU 2 MA ESID-0384 BP S234 EP S235 PG 2 WC Immunology SC Immunology GA AY1ZS UT WOS:000347389100197 ER PT J AU Sulemanji, DS Bao, FP Jiang, YD Kacmarek, RM AF Sulemanji, Demet S. Bao, Fangping Jiang, Yandong Kacmarek, Robert M. TI A Unidirectional Breathing Pattern Improves Breathing Efficiency in Subjects With Severe COPD SO RESPIRATORY CARE LA English DT Article DE pursed hp breathing; unidirectional breathing; COPD; dead space; breathing efficiency ID OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY DEAD SPACE; AIR FLOW; PRESSURE; TRACHEOSTOMY; EMPHYSEMA; MECHANICS; EFFICACY; DYSPNEA AB BACKGROUND: Unidirectional breathing (UB), nose-in mouth-out (NMB) or vice versa, is thought to create PEEP, stabilize small airways, and increase expiratory flow and exhaled tidal volume (V-T) in patients with expiratory obstructive disorders. However, the exact mechanism providing the benefits of UB remains unknown. Our hypothesis was that the benefits of UB are achieved mainly through reduction of upper airway dead space. METHODS: Sixteen stable COPD patients requiring oxygen use at home were enrolled in this prospective study at a tertiary health care center. A nasal mask and a mouthpiece were used, each having a removable one-way valve to direct the breathing pattern. Four experimentally defined patterns of spontaneous breathing, NMB, mouth-in nose-out (MNB), nose-in nose-out (NNB), and mouth-in mouth-out (MMB), were compared. Each breathing pattern lasted 5 min followed by a 5-min rest period. A NICO device continuously monitored respiratory parameters. The functional anatomical dead space volume (V-D) and expired V-T values were determined. Breathing efficiency (BE) was calculated as alveolar V-T divided by expired volume. RESULTS: Functional anatomical V-D was higher in bidirectional breathing (BB) (overall: 207.4 +/- 7.9 mL; MMB: 232.5 +/- 72.7 mL; NNB: 182.2 +/- 75 mL) compared to UB (overall: 178.1 +/- 87.2 mL; NMB: 176.9 +/- 91.3 mL; MNB: 179.3 +/- 83.2 mL) (P < .001). BE achieved with UB (overall: 76.2 +/- 6.5%; NMB: 76.8 +/- 6.8%; MNB: 75.6 +/- 6.3%) was higher than that with BB (overall: 66.2 +/- 0.09%; MMB: 64.3 +/- 0.10%; NNB: 68.1 +/- 0.08%) (P < .001). The difference in BE between UB and BB was more pronounced with small +/- values (UB: 73.8 +/- 0.08; BB: 49.4 +/- 0.09) than with large V-T values (UB: 77.3 +/- 0.06; BB: 63.0 +/- 0.07) (P < .001). CONCLUSIONS: Our data suggest that a reduction in functional anatomic V-D may be the underlying mechanism for the benefits associated with UB in COPD patients. (ClinicalTrials.gov registration NCT00784004.) C1 [Sulemanji, Demet S.; Bao, Fangping; Jiang, Yandong; Kacmarek, Robert M.] Harvard Univ, Sch Med, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA. [Sulemanji, Demet S.; Bao, Fangping; Jiang, Yandong; Kacmarek, Robert M.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bao, Fangping] Zhejiang Univ, Dept Anesthesia, Hangzhou 310003, Zhejiang, Peoples R China. [Kacmarek, Robert M.] Massachusetts Gen Hosp, Resp Care Serv Dept, Boston, MA 02114 USA. RP Kacmarek, RM (reprint author), Massachusetts Gen Hosp, 55 Fruit St,Warren 1225, Boston, MA 02114 USA. EM rkacmarek@partners.org FU Covidien; Hollister FX Drs Jiang and Kacmarek have patented a device that assists in assuring unidirectional breathing. However, this device has not been developed for manufacture or licensed to any company. Dr Kacmarek has received research grants from Covidien and Hollister and an honorarium for lecturing from Maquet and is a consultant for Covidien. NR 18 TC 1 Z9 1 U1 1 U2 2 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 EI 1943-3654 J9 RESP CARE JI Respir. Care PD OCT PY 2014 VL 59 IS 10 BP 1487 EP 1493 DI 10.4187/respcare.02899 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CA8WB UT WOS:000349200500003 PM 24782549 ER PT J AU Leblanc, P Moise, L Luza, C Chantaralawan, K Lezeau, L Yuan, JP Field, M Richer, D Boyle, C Martin, WD Fishman, JB Berg, EA Baker, D Zeigler, B Mais, DE Taylor, W Coleman, R Warren, HS Gelfand, JA De Groot, AS Brauns, T Poznansky, MC AF Leblanc, Pierre Moise, Leonard Luza, Cybelle Chantaralawan, Kanawat Lezeau, Lynchy Yuan, Jianping Field, Mary Richer, Daniel Boyle, Christine Martin, William D. Fishman, Jordan B. Berg, Eric A. Baker, David Zeigler, Brandon Mais, Dale E. Taylor, William Coleman, Russell Warren, H. Shaw Gelfand, Jeffrey A. De Groot, Anne S. Brauns, Timothy Poznansky, Mark C. TI VaxCelerate II: Rapid development of a self-assembling vaccine for Lassa fever SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Review DE emerging infectious diseases; Flu vaccine; Lassa fever virus; mycobacterium tuberculosis heat shock protein 70; peptide design; self-assembled vaccine; VaxCelerate; arenavirus; vaccine; 6MDP; 6-muramyl dipeptide; CGE; Capillary Gel Electrophoresis; CLO97; TLR7 ligand; CpG1826; Synthetic Oligodeoxynucleotide containing unmethylated dinucleotide sequences (Toll-like receptor 9 agonist); CTL; Cytotoxic T-lymphocyte; DARPA; Defense Advanced Research Projects Agency; EIDs; Emerging Infectious Diseases; GLP; Good Laboratory Practice; GMP; Good Manufacturing Practice; GP1; Glycoprotein-1; GP2; Glycoprotein-2; HLA; Human Leukocyte Antigen; HRP; Horseradish Peroxidase; LV; Lassa Fever Virus; MAV; Mycobacterium tuberculosis Heat Shock Protein 70-Avidin; MtbHSP70; Mycobacterium tuberculosis Heat Shock Protein 70; NHP; Non-human Primates; OVA; Ovalbumin; PAGE; Polyacrylamide Gel Electrophoresis; PBMC; Peripheral Blood Mononuclear Cell; PEG; Polyethyleneglycol; RVKR; Furin Cleavage Site (Arginine; Valine; Lysine; Arginine); SAV; Self-assembled vaccine; SAVL; Self-assembled vaccine formulated for Lassa Fever Virus ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; PROTECTS GUINEA-PIGS; T-CELL RESPONSES; TRANSGENIC MICE; YELLOW-FEVER; PEPTIDE ANTIGENS; IMMUNE-RESPONSES; FUSION PROTEINS; MOUSE MODEL; CD4(+) AB Development of effective vaccines against emerging infectious diseases (EID) can take as much or more than a decade to progress from pathogen isolation/identification to clinical approval. As a result, conventional approaches fail to produce field-ready vaccines before the EID has spread extensively. Lassa is a prototypical emerging infectious disease endemic to West Africa for which no successful vaccine is available. We established the VaxCelerate Consortium to address the need for more rapid vaccine development by creating a platform capable of generating and pre-clinically testing a new vaccine against specific pathogen targets in less than 120 d A self-assembling vaccine is at the core of the approach. It consists of a fusion protein composed of the immunostimulatory Mycobacterium tuberculosis heat shock protein 70 (MtbHSP70) and the biotin binding protein, avidin. Mixing the resulting protein (MAV) with biotinylated pathogen-specific immunogenic peptides yields a self-assembled vaccine (SAV). To meet the time constraint imposed on this project, we used a distributed R&D model involving experts in the fields of protein engineering and production, bioinformatics, peptide synthesis/design and GMP/GLP manufacturing and testing standards. SAV immunogenicity was first tested using H1N1 influenza specific peptides and the entire VaxCelerate process was then tested in a mock live-fire exercise targeting Lassa fever virus. We demonstrated that the Lassa fever vaccine induced significantly increased class II peptide specific interferon- CD4(+) T cell responses in HLA-DR3 transgenic mice compared to peptide or MAV alone controls. We thereby demonstrated that our SAV in combination with a distributed development model may facilitate accelerated regulatory review by using an identical design for each vaccine and by applying safety and efficacy assessment tools that are more relevant to human vaccine responses than current animal models. C1 [Leblanc, Pierre; Luza, Cybelle; Chantaralawan, Kanawat; Lezeau, Lynchy; Yuan, Jianping; Field, Mary; Richer, Daniel; Gelfand, Jeffrey A.; Brauns, Timothy; Poznansky, Mark C.] Massachusetts Gen Hosp, Vaccine & Immunotherapy Ctr, Charlestown, MA 02129 USA. [Moise, Leonard; Boyle, Christine; Martin, William D.; De Groot, Anne S.] EpiVax Inc, Providence, RI USA. [Fishman, Jordan B.; Berg, Eric A.] 21st Century Biochem, Marlborough, MA USA. [Baker, David] Univ Washington, Dept Biochem, Seattle, WA 98195 USA. [Baker, David] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA. [Zeigler, Brandon; Mais, Dale E.] MPI Res, Kalamazoo, MI USA. [Taylor, William; Coleman, Russell] Pfenex Inc, San Diego, CA USA. [Warren, H. Shaw] Massachusetts Gen Hosp, Boston, MA 02114 USA. RP Poznansky, MC (reprint author), Massachusetts Gen Hosp, Vaccine & Immunotherapy Ctr, Charlestown, MA 02129 USA. EM Mark_Poznansky@dfci.harvard.edu OI De Groot, Annie/0000-0001-5911-1459 FU US. Army Research Office [W911NF-13-1-0079]; CAPES Foundation, Ministry of Education of Brazil, Brasilia DF, Brazil FX This material is based upon work supported by the US. Army Research Office under contract No. W911NF-13-1-0079 and the generous support of Friends of VIC. CL was supported by CAPES Foundation, Ministry of Education of Brazil, Brasilia DF, 70040-020, Brazil. NR 81 TC 5 Z9 5 U1 2 U2 18 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD OCT PY 2014 VL 10 IS 10 BP 3022 EP 3038 DI 10.4161/hv.34413 PG 17 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AZ6FX UT WOS:000348315500043 PM 25483693 ER PT J AU Tseng, A Pomerantseva, I Cronce, MJ Kimura, AM Neville, CM Randolph, MA Vacanti, JP Sundback, CA AF Tseng, Alan Pomerantseva, Irina Cronce, Michael J. Kimura, Anya M. Neville, Craig M. Randolph, Mark A. Vacanti, Joseph P. Sundback, Cathryn A. TI Extensively Expanded Auricular Chondrocytes Form Neocartilage In Vivo SO CARTILAGE LA English DT Article DE engineered cartilage; chondrocytes; clinical-scale cell expansion; dedifferentiation ID MESENCHYMAL STEM-CELLS; HUMAN ARTICULAR CHONDROCYTES; CARTILAGE TISSUE FORMATION; FIBROBLAST-GROWTH-FACTOR; PASSAGED CHONDROCYTES; CLINICAL-APPLICATION; DIFFERENTIATION CAPACITY; NASAL AUGMENTATION; VITRO; EXPANSION AB Objective. Our goal was to engineer cartilage in vivo using auricular chondrocytes that underwent clinically relevant expansion and using methodologies that could be easily translated into health care practice. Design. Sheep and human chondrocytes were isolated from auricular cartilage biopsies and expanded in vitro. To reverse dedifferentiation, expanded cells were either mixed with cryopreserved P0 chondrocytes at the time of seeding onto porous collagen scaffolds or proliferated with basic fibroblast growth factor (bFGF). After 2-week in vitro incubation, seeded scaffolds were implanted subcutaneously in nude mice for 6 weeks. The neocartilage quality was evaluated histologically; DNA and glycosaminoglycans were quantified. Cell proliferation rates and collagen gene expression profiles were assessed. Results. Clinically sufficient over 500-fold chondrocyte expansion was achieved at passage 3 (P3); cell dedifferentiation was confirmed by the simultaneous COL1A1/3A1 gene upregulation and COL2A1 downregulation. The chondrogenic phenotype of sheep but not human P3 cells was rescued by addition of cryopreserved P0 chondrocytes. With bFGF supplementation, chondrocytes achieved clinically sufficient expansion at P2; COL2A1 expression was not rescued but COL1A1/3A1genes were downregulated. Although bFGF failed to rescue COL2A1 expression during chondrocyte expansion in vitro, elastic neocartilage with obvious collagen II expression was observed on porous collagen scaffolds after implantation in mice for 6 weeks. Conclusions. Both animal and human auricular chondrocytes expanded with low-concentration bFGF supplementation formed high-quality elastic neocartilage on porous collagen scaffolds in vivo. C1 [Tseng, Alan; Pomerantseva, Irina; Cronce, Michael J.; Kimura, Anya M.; Neville, Craig M.; Vacanti, Joseph P.; Sundback, Cathryn A.] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA. [Tseng, Alan; Pomerantseva, Irina; Cronce, Michael J.; Kimura, Anya M.; Neville, Craig M.; Vacanti, Joseph P.; Sundback, Cathryn A.] Ctr Regenerat Med, Boston, MA USA. [Pomerantseva, Irina; Neville, Craig M.; Randolph, Mark A.; Vacanti, Joseph P.; Sundback, Cathryn A.] Harvard Univ, Sch Med, Boston, MA USA. [Randolph, Mark A.] Massachusetts Gen Hosp, Plast Surg Res Lab, Boston, MA 02114 USA. RP Vacanti, JP (reprint author), 55 Fruit St,Warren 1151, Boston, MA 02114 USA. EM jvacanti@partners.org FU U.S. Army Medical Research and Materiel Command Award [W81XWH-12-1-0334]; Armed Forces Institute of Regenerative Medicine [W81XWH-08-2-0034] FX This research was sponsored by the U.S. Army Medical Research and Materiel Command Award Number W81XWH-12-1-0334 and by the Armed Forces Institute of Regenerative Medicine Award Number W81XWH-08-2-0034. The content of this article does not necessarily reflect the position or the policy of the government, and no official endorsement should be inferred. The fibrous collagen scaffolds were generously provided by the DSM Biomedical. NR 36 TC 3 Z9 3 U1 1 U2 10 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1947-6035 EI 1947-6043 J9 CARTILAGE JI Cartilage PD OCT PY 2014 VL 5 IS 4 BP 241 EP 251 DI 10.1177/1947603514546740 PG 11 WC Orthopedics SC Orthopedics GA AZ7ZP UT WOS:000348434700006 PM 26069703 ER PT J AU Arteaga, CL Adamson, PC Engelman, JA Foti, M Gaynor, RB Hilsenbeck, SG Limburg, PJ Lowe, SW Mardis, ER Ramsey, S Rebbeck, TR Richardson, AL Rubin, EH Weiner, GJ AF Arteaga, Carlos L. Adamson, Peter C. Engelman, Jeffrey A. Foti, Margaret Gaynor, Richard B. Hilsenbeck, Susan G. Limburg, Paul J. Lowe, Scott W. Mardis, Elaine R. Ramsey, Scott Rebbeck, Timothy R. Richardson, Andrea L. Rubin, Eric H. Weiner, George J. TI AACR CANCER PROGRESS REPORT 2014 Transforming Lives Through Research SO CLINICAL CANCER RESEARCH LA English DT Article ID CHRONIC LYMPHOCYTIC-LEUKEMIA; CHRONIC HEPATITIS-C; GRADE CERVICAL LESIONS; LARGE-CELL LYMPHOMA; UNITED-STATES; HUMAN CARCINOGENS; VIRUS-INFECTION; BREAST-CANCER; LUNG-CANCER; OPEN-LABEL C1 [Arteaga, Carlos L.] Vanderbilt Ingram Canc Ctr, Breast Canc Program, Nashville, TN 37232 USA. [Arteaga, Carlos L.] Vanderbilt Ingram Canc Ctr, Ctr Canc Targeted Therapies, Nashville, TN USA. [Adamson, Peter C.] Childrens Hosp Philadelphia, Div Clin Pharmacol & Therapeut, Philadelphia, PA 19104 USA. [Engelman, Jeffrey A.] Massachusetts Gen Hosp, Charlestown, MA USA. [Foti, Margaret] Amer Assoc Canc Res, Philadelphia, PA USA. [Gaynor, Richard B.] Eli Lilly & Co, Global Dev & Med Affairs, Indianapolis, IN 46285 USA. [Hilsenbeck, Susan G.] Baylor Coll Med, Ctr Canc, Breast Ctr, Houston, TX 77030 USA. [Limburg, Paul J.] Mayo Clin, Coll Med, Rochester, MN USA. [Lowe, Scott W.] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA. [Mardis, Elaine R.] Washington Univ, Sch Med, Genome Inst, St Louis, MO USA. [Ramsey, Scott] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Rebbeck, Timothy R.] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Richardson, Andrea L.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Rubin, Eric H.] Merck Res Labs, Oncol Clin Res, N Wales, PA USA. [Weiner, George J.] Univ Iowa, Holden Comprehens Canc Ctr, Iowa City, IA 52242 USA. RP Arteaga, CL (reprint author), Vanderbilt Ingram Canc Ctr, Breast Canc Program, Nashville, TN 37232 USA. FU NCI NIH HHS [U10 CA098543, U10 CA180886] NR 152 TC 15 Z9 15 U1 4 U2 8 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 EI 1557-3265 J9 CLIN CANCER RES JI Clin. Cancer Res. PD OCT 1 PY 2014 VL 20 SU 1 BP S1 EP S100 DI 10.1158/1078-0432.CCR-14-2123 PG 100 WC Oncology SC Oncology GA CA0HH UT WOS:000348597300001 PM 25228531 ER PT J AU Figgie, MP Wright, TM Drinkwater, D Brown, TD D'Lima, DD Greenwald, AS Harman, MK Kurtz, SM Mihalko, WM Muratoglu, OK Rimnac, CM Wimmer, MA AF Figgie, Mark P. Wright, Timothy M. Drinkwater, Denise Brown, Thomas D. D'Lima, Darryl D. Greenwald, A. Seth Harman, Melinda K. Kurtz, Steven M. Mihalko, William M. Muratoglu, Orhun K. Rimnac, Clare M. Wimmer, Markus A. CA Bioengn Working Grp TI What Design and Material Factors Impact the Wear and Corrosion Performance in Total Elbow Arthroplasties? (vol 472, pg 3770, 2014) SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Correction C1 [Figgie, Mark P.; Wright, Timothy M.; Drinkwater, Denise] Hosp Special Surg, New York, NY USA. [Brown, Thomas D.] Univ Iowa, Iowa City, IA USA. [D'Lima, Darryl D.] Shiley Ctr Orthop Res & Educ, La Jolla, CA USA. [Greenwald, A. Seth] Orthop Res Labs, Cleveland, OH USA. [Harman, Melinda K.] Clemson Univ, Clemson, SC USA. [Kurtz, Steven M.] Drexel Univ, Philadelphia, PA USA. [Mihalko, William M.] Campbell Clin Orthop & BME, Memphis, TN USA. [Muratoglu, Orhun K.] Massachussetts Gen Hosp, Boston, MA USA. [Rimnac, Clare M.] Case Western Reserve Univ, Cleveland, OH USA. [Wimmer, Markus A.] Rush Univ Med Ctr, Chicago, IL USA. NR 1 TC 0 Z9 0 U1 2 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X EI 1528-1132 J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD OCT PY 2014 VL 472 IS 10 BP 3245 EP 3245 DI 10.1007/s11999-014-3864-7 PG 1 WC Orthopedics; Surgery SC Orthopedics; Surgery GA AP2NN UT WOS:000341909300052 ER PT J AU Gandaglia, G Varda, B Sood, A Pucheril, D Konijeti, R Sammon, JD Sukumar, S Menon, M Sun, M Chang, SL Montorsi, F Kibel, AS Trinh, QD AF Gandaglia, Giorgio Varda, Briony Sood, Akshay Pucheril, Daniel Konijeti, Ramdev Sammon, Jesse D. Sukumar, Shyam Menon, Mani Sun, Maxine Chang, Steven L. Montorsi, Francesco Kibel, Adam S. Quoc-Dien Trinh TI Short-term perioperative outcomes of patients treated with radical cystectomy for bladder cancer included in the National Surgical Quality Improvement Program (NSQIP) database SO CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL LA English DT Article ID IN-HOSPITAL COMPLICATIONS; AMERICAN-COLLEGE; RISK-FACTORS; MORTALITY; PRESERVATION; VALIDATION; CONSORTIUM; MORBIDITY; TRENDS; IMPACT AB Introduction: We report the contemporary outcomes of radical cystectomy (RC) in patients with bladder cancer using a national, prospective perioperative database specifically developed to assess the quality of surgical care. Methods: The National Surgical Quality Improvement Program (NSQIP) database was queried from 2006 to 2011 for RC. Data on postoperative complications, operative time, length of stay, blood transfusions, readmission, and mortality within 30 days from surgery were abstracted. Results: Overall, 1094 patients undergoing RC were identified. Rates of overall complications, transfusions, prolonged length of hospitalization, readmission, and perioperative mortality were 31.1%, 34.4%, 25.9%, 20.2%, and 2.7%, respectively. Body mass index represented an independent predictor of overall complications on multivariate analysis (p = 0.04). Baseline comorbidity status was associated with increased odds of postoperative complications, prolonged operative time, transfusion, prolonged hospitalization, and perioperative mortality. In particular, patients with cardiovascular comorbidities were 2.4 times more likely to die within 30 days following cystectomy compared to their healthier counterparts (p = 0.04). Men had lower odds of prolonged operative time and blood transfusions (p <= 0.03). Finally, the receipt of a continent urinary diversion was the only predictor of readmission (p = 0.02). Our results are limited by their retrospective nature and by the lack of adjustment for hospital and tumour volume. Conclusions: Complications, transfusions, readmission, and perioperative mortality remain relatively common events in patients undergoing RC for bladder cancer. In an era where many advocate the need for prospective multi-institutional data collection as a means of improving quality of care, our study provides data on short-term outcomes after RC from a national quality improvement initiative. C1 [Gandaglia, Giorgio; Varda, Briony; Sun, Maxine] Univ Montreal, Ctr Hlth, Canc Prognost & Hlth Outcomes Unit, Montreal, PQ, Canada. [Gandaglia, Giorgio; Montorsi, Francesco] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Urol Res Inst, Milan, Italy. [Varda, Briony; Konijeti, Ramdev; Chang, Steven L.; Kibel, Adam S.; Quoc-Dien Trinh] Harvard Univ, Sch Med, Dana Farber Canc Inst, Brigham & Womens Hosp,Div Urol Surg, Boston, MA 02115 USA. [Varda, Briony; Konijeti, Ramdev; Chang, Steven L.; Kibel, Adam S.; Quoc-Dien Trinh] Harvard Univ, Sch Med, Dana Farber Canc Inst, Brigham & Womens Hosp,Ctr Surg Publ Hlth, Boston, MA 02115 USA. [Sood, Akshay; Pucheril, Daniel; Sammon, Jesse D.; Menon, Mani] Henry Ford Hlth Syst, Vattikuti Urol Inst, Detroit, MI USA. [Sukumar, Shyam] Univ Minnesota, Dept Urol, Minneapolis, MN USA. RP Gandaglia, G (reprint author), Univ Montreal, Ctr Hlth, Canc Prognost & Hlth Outcomes Unit, 264 Blvd Rene Levesque E 228, Montreal, PQ, Canada. EM giorgio.gandaglia@gmail.com FU Women's Hospital FX The American College of Surgeons National Surgical Quality Improvement Program and the hospitals participating in the ACS NSQIP are the source of the data used herein; they have not verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors. This work is supported by the Professor Walter Morris-Hale Distinguished Chair in Urologic Oncology at Brigham and Women's Hospital. NR 30 TC 7 Z9 7 U1 0 U2 2 PU CANADIAN UROLOGICAL ASSOCIATION PI DORVAL PA 185 DORVAL AVENUE, STE 401, DORVAL, QC H9S 5J9, CANADA SN 1911-6470 EI 1920-1214 J9 CUAJ-CAN UROL ASSOC JI CUAJ-Can. Urol. Assoc. J. PD OCT PY 2014 VL 8 IS 9-10 BP E681 EP E687 DI 10.5489/cuaj.2069 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA AY6ZB UT WOS:000347710000003 PM 25408807 ER PT J AU Trudeau, V Gandaglia, G Shiffmann, J Popa, I Shariat, SF Montorsi, F Perrotte, P Trinh, QD Karakiewicz, PI Sun, M AF Trudeau, Vincent Gandaglia, Giorgio Shiffmann, Jonas Popa, Ioana Shariat, Shahrokh F. Montorsi, Francesco Perrotte, Paul Quoc-Dien Trinh Karakiewicz, Pierre I. Sun, Maxine TI Robot-assisted versus laparoscopic nephroureterectomy for upper-tract urothelial cancer: A population-based assessment of costs and perioperative outcomes SO CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL LA English DT Article ID OPEN RADICAL PROSTATECTOMY; SINGLE-SITE SURGERY; PARTIAL NEPHRECTOMY; CARCINOMA; TECHNOLOGY; GUIDELINES; EXPERIENCE; TRENDS; SAMPLE; SERIES AB Introduction: We compared short-term outcomes and costs between robotic-assisted nephroureterectomy (RANU) and laparoscopic radical nephroureterectomy (LNU) in a large populationbased cohort of patients with upper-tract urothelial carcinoma (UTUC). Methods: Overall, 1914 patients with UTUC treated with RANU or LNU between 2008 and 2010 within the Nationwide Inpatient Sample were abstracted. Propensity-score matching was performed to account for inherent differences between patients undergoing RANU and LNU. Multivariable logistic regression models were fitted to compare postoperative complications, blood transfusions, prolonged length of stay, and costs between the 2 procedures. Results: Overall, a weighted estimate of 1199 (62.6%) and 715 (37.4%) patients received LNU and RANU, respectively. In multivariable analyses no significant differences were observed in postoperative transfusion and length of stay between the 2 surgical approaches (all p > 0.1). However, patients undergoing RANU were less likely to experience any complications compared to their counterparts undergoing LNU (p = 0.04). The utilization of RANU was associated with substantially higher costs compared to the laparoscopic approach. Our study is limited by its retrospective nature and the lack of adjustment for tumour stage and grade. Conclusions: Our results support the safety and feasibility of RANU for the treatment of UTUC. Indeed, the use of the robotic approach was associated with lower probability of experiencing perioperative complications compared to LNU. On the other hand, the utilization of RANU is associated with higher costs compared to LNU. C1 [Trudeau, Vincent; Gandaglia, Giorgio; Shiffmann, Jonas; Popa, Ioana; Karakiewicz, Pierre I.; Sun, Maxine] Univ Montreal, Ctr Hlth, Canc Prognost & Hlth Outcomes Unit, Montreal, PQ, Canada. [Gandaglia, Giorgio; Montorsi, Francesco] San Raffaele Univ Milan, Dept Urol, Vita Salute, Milan, Italy. [Shiffmann, Jonas] Prostate Canc Ctr Hamburg Eppendorf, Martini Clin, Hamburg, Germany. [Shariat, Shahrokh F.] Med Univ Vienna, Dept Urol, Vienna, Austria. [Perrotte, Paul; Karakiewicz, Pierre I.] Univ Montreal, Ctr Hlth, Dept Urol, Montreal, PQ, Canada. [Quoc-Dien Trinh] Harvard Univ, Sch Med, Dana Farber Canc Inst, Brigham & Womens Hosp,Dept Surg,Div Urol, Boston, MA 02115 USA. RP Trudeau, V (reprint author), Canc Prognost & Hlth Outcomes Unit, 264 Blvd Rene Levesque E Suite 228, Montreal, PQ H2X 1P1, Canada. EM vincent.trudeau.1@umontreal.ca FU University of Montreal Health Centre Urology Specialists, Fonds de la Recherche en Sante du Quebec; University of Montreal Department of Surgery; University of Montreal Health Centre (CHUM) Foundation FX Dr. Trudeau, Dr. Gandaglia, Dr. Shiffmann, Dr. Popa, Dr. Shariat, Dr. Montorsi, Dr. Perrotte and Dr. Sun all declare no competing financial or personal interests. Dr. Trinh received honorarium from Intuitive Surgical in the past. Dr. Karakiewicz is partially supported by the University of Montreal Health Centre Urology Specialists, Fonds de la Recherche en Sante du Quebec, the University of Montreal Department of Surgery and the University of Montreal Health Centre (CHUM) Foundation. NR 29 TC 6 Z9 6 U1 0 U2 0 PU CANADIAN UROLOGICAL ASSOCIATION PI DORVAL PA 185 DORVAL AVENUE, STE 401, DORVAL, QC H9S 5J9, CANADA SN 1911-6470 EI 1920-1214 J9 CUAJ-CAN UROL ASSOC JI CUAJ-Can. Urol. Assoc. J. PD OCT PY 2014 VL 8 IS 9-10 BP E695 EP E701 DI 10.5489/cuaj.2051 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA AY6ZB UT WOS:000347710000005 PM 25408809 ER PT J AU Kranzler, HR Feinn, R Gelernter, J Pond, T Covault, J AF Kranzler, Henry R. Feinn, Richard Gelernter, Joel Pond, Timothy Covault, Jonathan TI Topiramate's Reduction of Body Mass Index in Heavy Drinkers: Lack of Moderation by a GRIK1 Polymorphism SO EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY LA English DT Article DE body mass index; heavy drinkers; pharmacogenetics; topiramate; weight loss ID RANDOMIZED CONTROLLED-TRIAL; ALCOHOL DEPENDENCE; WEIGHT-LOSS; NEURONS; CURRENTS; RELEASE AB Topiramate, which interacts with multiple neurotransmitter and enzyme systems, is approved by the Food and Drug Administration to treat seizure disorder, prevent migraine, and (in combination with phentermine) reduce weight. Topiramate has also been shown in multiple studies to reduce heavy drinking. The authors found that topiramate 200 mg/day significantly reduced heavy drinking in heavy drinkers with a treatment goal of reduced drinking (Kranzler et al., 2014). Further, in the European American (EA) subsample (n = 122), a single nucleotide polymorphism (rs2832407) in GRIK1, which encodes the GluK1 subunit of the kainate receptor, moderated the effect on heavy drinking days. Here the authors examined the effects of topiramate on body mass index (BMI) and the moderating effect of rs2832407 in the EA subsample from Kranzler et al. (2014). Across the 12 weeks of treatment, BMI was reduced by 1.2 kg/m2 (p < .001) in the topiramate group but was unchanged in the placebo group. There was no evidence of moderation by rs2832407 of topiramate's effects on BMI. Controlling for changes in drinking and other potential confounders did not alter the findings. These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight, the specific mechanism of which remains to be determined. C1 [Kranzler, Henry R.; Pond, Timothy] Univ Penn, Perelman Sch Med, Ctr Studies Addict, Dept Psychiat, Philadelphia, PA 19104 USA. [Kranzler, Henry R.] Philadelphia Vet Affairs Med Ctr, Mental Illness Res Educ & Clin Ctr VISN4, Philadelphia, PA USA. [Feinn, Richard] Quinnipiac Univ, Dept Med Sci, Frank Netter Sch Med, Hamden, CT USA. [Gelernter, Joel] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Gelernter, Joel] Vet Affairs Connecticut, West Haven, CT USA. [Covault, Jonathan] Univ Connecticut, Sch Med, Alcohol Res Ctr, Dept Psychiat, Storrs, CT USA. RP Kranzler, HR (reprint author), Univ Penn, Perelman Sch Med, Treatment Res Ctr, 3900 Chestnut St, Philadelphia, PA 19104 USA. EM kranzler@mail.med.upenn.edu FU National Institutes of Health [P60 AA03510, K24 AA13736]; VISN 4 Mental Illness Research, Education, and Clinical Center of the Philadelphia Veterans Affairs Medical Center; AbbVie; Ethypharm; Lilly; Lundbeck; Pfizer FX This study was supported by National Institutes of Health Grants P60 AA03510 and K24 AA13736 and by the VISN 4 Mental Illness Research, Education, and Clinical Center of the Philadelphia Veterans Affairs Medical Center. The funding sources had no role other than financial support. The authors acknowledge the assistance in the conduct of this study provided by the staff of the Clinical Research and Evaluation Unit at the University of Connecticut Health Center and the Treatment Research Center of the University of Pennsylvania Perelman School of Medicine. Henry R. Kranzler has been a consultant or advisory board member for the following pharmaceutical companies: Alkermes, Lilly, Lundbeck, Pfizer, and Roche. He is also a member of the American Society of Clinical Psychopharmacology's Alcohol Clinical Trials Initiative, which is supported by AbbVie, Ethypharm, Lilly, Lundbeck, and Pfizer. www.clinicaltrials.govregistration#NCT00626925. NR 25 TC 1 Z9 1 U1 0 U2 0 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1064-1297 EI 1936-2293 J9 EXP CLIN PSYCHOPHARM JI Exp. Clin. Psychopharmacol. PD OCT PY 2014 VL 22 IS 5 BP 419 EP 423 DI 10.1037/a0037309 PG 5 WC Psychology, Biological; Psychology, Clinical; Pharmacology & Pharmacy; Psychiatry SC Psychology; Pharmacology & Pharmacy; Psychiatry GA AZ6EF UT WOS:000348310700005 PM 24978347 ER PT J AU Perrachione, TK Stepp, CE Hillman, RE Wong, PCM AF Perrachione, Tyler K. Stepp, Cara E. Hillman, Robert E. Wong, Patrick C. M. TI Talker Identification Across Source Mechanisms: Experiments With Laryngeal and Electrolarynx Speech SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH LA English DT Article DE voice; speech; social communication; augmentative and alternative communication ID QUALITY-OF-LIFE; SPEAKER IDENTITY; FAMILIAR VOICES; PERCEPTION; RECOGNITION; VOWELS; DISCRIMINATION; REHABILITATION; LANGUAGE; OUTCOMES AB Purpose: The purpose of this study was to determine listeners' ability to learn talker identity from speech produced with an electrolarynx, explore source and filter differentiation in talker identification, and describe acoustic-phonetic changes associated with electrolarynx use. Method: Healthy adult control listeners learned to identify talkers from speech recordings produced using talkers' normal laryngeal vocal source or an electrolarynx. Listeners' abilities to identify talkers from the trained vocal source (Experiment 1) and generalize this knowledge to the untrained source (Experiment 2) were assessed. Acoustic-phonetic measurements of spectral differences between source mechanisms were performed. Additional listeners attempted to match recordings from different source mechanisms to a single talker (Experiment 3). Results: Listeners successfully learned talker identity from electrolarynx speech but less accurately than from laryngeal speech. Listeners were unable to generalize talker identity to the untrained source mechanism. Electrolarynx use resulted in vowels with higher F1 frequencies compared with laryngeal speech. Listeners matched recordings from different sources to a single talker better than chance. Conclusions: Electrolarynx speech, although lacking individual differences in voice quality, nevertheless conveys sufficient indexical information related to the vocal filter and articulation for listeners to identify individual talkers. Psychologically, perception of talker identity arises from a "gestalt" of the vocal source and filter. C1 [Perrachione, Tyler K.; Stepp, Cara E.] Boston Univ, Boston, MA 02215 USA. [Perrachione, Tyler K.; Stepp, Cara E.] MIT, Cambridge, MA 02139 USA. [Stepp, Cara E.; Hillman, Robert E.] Harvard Univ, Cambridge, MA 02138 USA. [Stepp, Cara E.; Hillman, Robert E.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Wong, Patrick C. M.] Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. [Wong, Patrick C. M.] Northwestern Univ, Evanston, IL USA. RP Wong, PCM (reprint author), Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. EM tkp@bu.edu; p.wong@cuhk.edu.hk FU Massachusetts General Hospital; National Institutes of Health (NIH) [5T32DC000038-17, 5T32HD007424]; National Science Foundation (NSF) [BCS-0719666, BCS-1125144]; NIH [R01DC008333, K02AG035382]; NSF Graduate Research Fellowship FX We thank James Heaton, Satrajit Ghosh, Yoomin Ahn, Louisa Ha, Allison Barr, Nicole Lomotan, Rachel Gould, and James Sugarman for their contributions. This work was supported by the Massachusetts General Hospital, through funding to Robert E. Hillman; National Institutes of Health (NIH) Grants 5T32DC000038-17 and 5T32HD007424 to Cara E. Stepp; and National Science Foundation (NSF) Grants BCS-0719666 and BCS-1125144 and NIH Grants R01DC008333 and K02AG035382 to Patrick C. M. Wong. Tyler K. Perrachione was supported by an NSF Graduate Research Fellowship. NR 48 TC 0 Z9 0 U1 4 U2 10 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1092-4388 EI 1558-9102 J9 J SPEECH LANG HEAR R JI J. Speech Lang. Hear. Res. PD OCT PY 2014 VL 57 IS 5 BP 1651 EP 1665 DI 10.1044/2014_JSLHR-S-13-0161 PG 15 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA AZ4NZ UT WOS:000348200500006 PM 24801962 ER PT J AU Sullivan, MP Griffiths, GG Sohlberg, MM AF Sullivan, Michael P. Griffiths, Gina G. Sohlberg, Mckay Moore TI Effect of Posttraumatic Stress on Study Time in a Task Measuring Four Component Processes Underlying Text-Level Reading SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH LA English DT Article DE posttraumatic stress; attention; processing speed; reading comprehension ID ATTENTIONAL CONTROL-THEORY; WORKING-MEMORY CAPACITY; TEST ANXIETY; COGNITIVE PERFORMANCE; MIND; COMPREHENSION; DISORDER AB Purpose: To investigate the effect of combat-related posttraumatic stress disorder (PTSD) on 4 components underlying text-level reading comprehension. Method: A group of 17 veterans with PTSD and 17 matched control participants took part. An experimental task required participants to read and study 3-sentence paragraphs describing semantic features associated with real and unreal objects. Each paragraph was followed by true-false statements that assessed knowledge access, text memory, inference, and integration. Results: The results revealed that the PTSD group took significantly longer than the control group to study the paragraphs. Although there was no group difference in test statement accuracy, the PTSD group also took significantly longer to respond to the test statements. Conclusions: Overall, the results provide evidence for the control theory of attention but suggest that more direct measures of task-irrelevant processing during text-level reading are needed. More important, the results begin to lay a foundation for developing not only diagnostic but also intervention strategies. C1 [Sullivan, Michael P.] Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97201 USA. [Griffiths, Gina G.; Sohlberg, Mckay Moore] Univ Oregon, Eugene, OR 97403 USA. RP Sullivan, MP (reprint author), Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97201 USA. EM sullivan@ohsu.edu FU National Science Foundation [1012947] FX This work was supported by National Science Foundation Grant 1012947. NR 48 TC 3 Z9 3 U1 0 U2 2 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1092-4388 EI 1558-9102 J9 J SPEECH LANG HEAR R JI J. Speech Lang. Hear. Res. PD OCT PY 2014 VL 57 IS 5 BP 1731 EP 1739 DI 10.1044/2014_JSLHR-L-13-0238 PG 9 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA AZ4NZ UT WOS:000348200500012 PM 24686914 ER PT J AU Soriano, ER Acosta-Felquer, ML Luong, P Caplan, L AF Roberto Soriano, Enrique Laura Acosta-Felquer, Maria Luong, Phat Caplan, Liron TI Pharmacologic treatment of psoriatic arthritis and axial spondyloarthritis with traditional biologic and non-biologic DMARDs SO BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY LA English DT Article DE NLM MeSH terms; Arthritis; Psoriatic; Spondylitis; Ankylosing; Therapeutics; Biological therapies ID PLACEBO-CONTROLLED TRIAL; REFRACTORY ANKYLOSING-SPONDYLITIS; OPEN-LABEL TRIAL; ORAL PHOSPHODIESTERASE-4 INHIBITOR; EVIDENCE-BASED RECOMMENDATIONS; MODIFYING ANTIRHEUMATIC DRUGS; SYSTEMATIC LITERATURE SEARCH; RANDOMIZED CONTROLLED-TRIALS; DECREASED CLINICAL-RESPONSE; ASAS CONSENSUS STATEMENT AB This manuscript focuses on the pharmacologic treatment of psoriatic arthritis and axial spondyloarthritis - including ankylosing spondylitis using traditional biologic and non-biologic disease-modifying antirheumatic drugs. Early treatment of psoriatic arthritis and axial spondyloarthritis/ankylosing spondylitis as well as the treat-to-target concept receive particular attention. This review also surveys recent national and international guidelines for the treatment of both psoriatic arthritis and couches practice recommendations for axial spondyloarthritis/ankylosing spondylitis within the context of various international guidelines. Published by Elsevier Ltd. C1 [Roberto Soriano, Enrique; Laura Acosta-Felquer, Maria] Hosp Italiano Buenos Aires, Internal Med Serv, Rheumatol Unit, Buenos Aires, DF, Argentina. [Roberto Soriano, Enrique; Laura Acosta-Felquer, Maria] Inst Univ, Caba, Argentina. [Luong, Phat; Caplan, Liron] Denver Vet Affairs Hosp, Rheumatol Sect, Aurora, CO 80045 USA. [Luong, Phat; Caplan, Liron] Univ Colorado, Sch Med, Aurora, CO 80045 USA. RP Caplan, L (reprint author), Denver Vet Affairs Hosp, Rheumatol Sect, 1775 Aurora Court,B115, Aurora, CO 80045 USA. EM enrique.soriano@hospitalitaliano.org.ar; marial.acosta@hospitalitaliano.org.ar; phat.luong@va.gov; liron.caplan@ucdenver.edu FU U.S. Department of Veterans Affairs (VA) FX All authors acknowledge that they have no financial and personal relationships with other people or organizations that could inappropriately influence the content of this article. This project received no specific function. Dr. Caplan is supported by the U.S. Department of Veterans Affairs (VA); however, the VA had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. NR 99 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1521-6942 EI 1521-1770 J9 BEST PRACT RES CL RH JI Best Pract. Res. Clin. Rheumatol. PD OCT PY 2014 VL 28 IS 5 BP 793 EP 806 DI 10.1016/j.berh.2014.10.011 PG 14 WC Rheumatology SC Rheumatology GA AZ1PC UT WOS:000348009600011 PM 25488785 ER PT J AU Ladra, MM Edgington, SK Mahajan, A Grosshans, D Szymonifka, J Khan, F Moteabbed, M Friedmann, AM MacDonald, SM Tarbell, NJ Yock, TI AF Ladra, Matthew M. Edgington, Samantha K. Mahajan, Anita Grosshans, David Szymonifka, Jackie Khan, Fazal Moteabbed, Maryam Friedmann, Alison M. MacDonald, Shannon M. Tarbell, Nancy J. Yock, Torunn I. TI A dosimetric comparison of proton and intensity modulated radiation therapy in pediatric rhabdorhyosarcoma patients enrolled on a prospective phase II proton study SO RADIOTHERAPY AND ONCOLOGY LA English DT Article DE Pediatrics; Rhabdomyosarcoma; Protons ID MEDIASTINAL HODGKIN LYMPHOMA; CHILDHOOD-CANCER SURVIVOR; CHILDRENS ONCOLOGY GROUP; GROWTH-HORMONE; RISK RHABDOMYOSARCOMA; BRAIN-TUMORS; RADIOTHERAPY; OUTCOMES; PHOTON; REDUCTION AB Background: Pediatric rhabdomyosarcoma (RMS) is highly curable, however, cure may come with significant radiation related toxicity in developing tissues. Proton therapy (PT) can spare excess dose to normal structures, potentially reducing the incidence of adverse effects. Methods: Between 2005 and 2012,54 patients were enrolled on a prospective multi-institutional phase II trial using PT in pediatric RMS. As part of the protocol, intensity modulated radiation therapy (IMRT) plans were generated for comparison with clinical PT plans. Results: Target coverage was comparable between PT and IMRT plans with a mean CTV V-95 of 100% for both modalities (p = 0.82). However, mean integral dose was 1.8 times higher for IMRT (range 1.0-4.9). By site, mean integral dose for IMRT was 1.8 times higher for H&N (p < 0.01) and GU (p = 0.02), 2.0 times higher for trunk/extremity (p < 0.01), and 3.5 times higher for orbit (p < 0.01) compared to PT. Significant sparing was seen with PT in 26 of 30 critical structures assessed for orbital, head and neck, pelvic, and trunk/extremity patients. Conclusions: Proton radiation lowers integral dose and improves normal tissue sparing when compared to IMRT for pediatric RMS. Correlation with clinical outcomes is necessary once mature long-term toxicity data are available. (C) 2014 Elsevier Ireland Ltd. All rights reserved. C1 [Ladra, Matthew M.; Edgington, Samantha K.; Szymonifka, Jackie; Khan, Fazal; Moteabbed, Maryam; Friedmann, Alison M.; MacDonald, Shannon M.; Tarbell, Nancy J.; Yock, Torunn I.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Mahajan, Anita; Grosshans, David] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. RP Yock, TI (reprint author), Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. EM tyock@partners.org FU NCI NIH HHS [P01 CA021239] NR 43 TC 18 Z9 18 U1 0 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-8140 J9 RADIOTHER ONCOL JI Radiother. Oncol. PD OCT PY 2014 VL 113 IS 1 BP 77 EP 83 DI 10.1016/j.radonc.2014.08.033 PG 7 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA AY5IB UT WOS:000347604800013 PM 25443861 ER PT J AU Yock, TI Bhat, S Szymonifka, J Yeap, BY Delahaye, J Donaldson, SS MacDonald, SM Pulsifer, MB Hill, KS DeLaney, TF Ebb, D Huang, M Tarbell, NJ Fisher, PG Kuhlthau, KA AF Yock, Torunn I. Bhat, Sundeep Szymonifka, Jackie Yeap, Beow Y. Delahaye, Jennifer Donaldson, Sarah S. MacDonald, Shannon M. Pulsifer, Margaret B. Hill, Kristen S. DeLaney, Thomas F. Ebb, David Huang, Mary Tarbell, Nancy J. Fisher, Paul Graham Kuhlthau, Karen A. TI Quality of life outcomes in proton and photon treated pediatric brain tumor survivors SO RADIOTHERAPY AND ONCOLOGY LA English DT Article DE QoL; Proton radiotherapy; Outcomes; Pediatric brain tumors; Late effects ID GENERIC CORE SCALES; CHILDHOOD-CANCER SURVIVOR; ADULT SURVIVORS; RADIOTHERAPY; CHILDREN; MEDULLOBLASTOMA; PEDSQL(TM)-4.0; RELIABILITY; VALIDITY; THERAPY AB Background: Radiotherapy can impair Health Related Quality of Life (HRQoL) in survivors of childhood brain tumors, but proton radiotherapy (PRT) may mitigate this effect. This study compares HRQoL in PRT and photon (XRT) pediatric brain tumor survivors. Methods: HRQoL data were prospectively collected on PRT-treated patients aged 2-18 treated at Massachusetts General Hospital (MGH). Cross-sectional PedsQL data from XRT treated Lucile Packard Children's Hospital (LPCH) patients provided the comparison data. Results: Parent proxy HRQoL scores were reported at 3 years for the PRT cohort (PRT-C) and 2.9 years (median) for the XRT cohort (XRT-C). The total core HRQoL score for the PRT-C, XRT-C, and normative population differed from one another and was 75.9, 65.4 and 80.9 respectively (p = 0.002; p = 0.024; p < 0.001). The PRT-C scored 10.3 and 10.5 points higher than the XRT-C in the physical (PhSD) and psychosocial (PsSD) summary domains of the total core score (TCS, p = 0.015; p = 0.001). The PRT-C showed no difference in PhSD compared with the normative population, but scored 6.1 points less in the PsSD (p = 0.003). Compared to healthy controls, the XRT-C scored lower in all domains (p < 0.001). Conclusions: The HRQoL of pediatric brain tumor survivors treated with PRT compare favorably to those treated with XRT and similar to healthy controls in the PhSD. (C) 2014 Elsevier Ireland Ltd. All rights reserved. C1 [Yock, Torunn I.; MacDonald, Shannon M.; DeLaney, Thomas F.; Tarbell, Nancy J.] Massachusetts Gen Hosp, Dept Radiat Oncol, Proton Ctr, Boston, MA 02114 USA. [Bhat, Sundeep] Kaiser Permanente, Santa Clara Med Ctr, Dept Emergency Med, Boston, MA USA. [Szymonifka, Jackie; Yeap, Beow Y.] Massachusetts Gen Hosp, Dept Med, Biostat Unit, Boston, MA 02114 USA. [Delahaye, Jennifer; Hill, Kristen S.] Massachusetts Gen Hosp, Ctr Child & Adolescent Hlth Policy, Boston, MA 02114 USA. [Donaldson, Sarah S.] Massachusetts Gen Hosp, Stanford Canc Ctr, Dept Radiat Oncol, Boston, MA 02114 USA. [Pulsifer, Margaret B.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Ebb, David; Huang, Mary] Massachusetts Gen Hosp, Dept Pediat Oncol, Proton Ctr, Boston, MA 02114 USA. [Fisher, Paul Graham] Stanford Univ, Med Ctr, Dept Neurol, Palo Alto, CA 94304 USA. [Kuhlthau, Karen A.] Harvard Univ, Sch Med, Dept Pediat, Ctr Child & Adolescent Hlth Policy,Massachusetts, Boston, MA 02115 USA. RP Yock, TI (reprint author), Massachusetts Gen Hosp, Dept Radiat Oncol, Proton Ctr, 55 Fruit St,Room 110, Boston, MA 02114 USA. EM tyock@partners.org FU National Cancer Institute [P01CA021239]; Susan McDaniel Brain Tumor Fund; MGH Marathon Fund for Pediatric Cancer; National Brain Tumor Foundation Pediatric Research Grant FX Funding for the MGH project was supported by Award Number P01CA021239 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. The project was also supported in part by the Susan McDaniel Brain Tumor Fund and the MGH Marathon Fund for Pediatric Cancer. Funding for the LPCH project was from the National Brain Tumor Foundation Pediatric Research Grant. NR 34 TC 11 Z9 11 U1 2 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-8140 J9 RADIOTHER ONCOL JI Radiother. Oncol. PD OCT PY 2014 VL 113 IS 1 BP 89 EP 94 DI 10.1016/j.radonc.2014.08.017 PG 6 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA AY5IB UT WOS:000347604800015 PM 25304720 ER PT J AU Li, WD Huang, PG Chen, DJ Gerweck, LE AF Li, Wende Huang, Peigen Chen, David J. Gerweck, Leo E. TI Determinates of tumor response to radiation: Tumor cells, tumor stroma and permanent local control SO RADIOTHERAPY AND ONCOLOGY LA English DT Article DE Radiation; Tumor control dose; Intrinsic radiosensitivity; Tumor vasculature; Predictive assays ID DEPENDENT PROTEIN-KINASE; METASTATIC DISSEMINATION; SENSITIVITY; RADIOSENSITIVITY; CARCINOMA; SURVIVAL; RADIOTHERAPY; IMPACT AB Background and purpose: The causes of tumor response variation to radiation remain obscure, thus hampering the development of predictive assays and strategies to decrease resistance. The present study evaluates the impact of host tumor stromal elements and the in vivo environment on tumor cell kill, and relationship between tumor cell radiosensitivity and the tumor control dose. Material and methods: Five endpoints were evaluated and compared in a radiosensitive DNA double-strand break repair-defective (DNA-PKcs(-/-)) tumor line, and its DNA-PKcs repair competent transfected counterpart. In vitro colony formation assays were performed on in vitro cultured cells, on cells obtained directly from tumors, and on cells irradiated in situ. Permanent local control was assessed by the TCD50 assay. Vascular-effects were evaluated by functional vascular density assays. Results: The fraction of repair competent and repair deficient tumor cells surviving radiation did not substantially differ whether irradiated in vitro, i.e., in the absence of host stromal elements and factors, from the fraction of cells killed following in vivo irradiation. Additionally, the altered tumor cell sensitivity resulted in a proportional change in the dose required to achieve permanent local control. The estimated number of tumor cells per tumor, their cloning efficiency and radiosensitivity, all assessed by in vitro assays, were used to predict successfully, the measured tumor control doses. Conclusion: The number of clonogens per tumor and their radiosensitivity govern the permanent local control dose. Published by Elsevier Ireland Ltd. C1 [Li, Wende; Huang, Peigen; Gerweck, Leo E.] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. [Li, Wende] Guangdong Med Coll, Guangzhou, Guangdong, Peoples R China. [Chen, David J.] Univ Texas SW Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA. RP Gerweck, LE (reprint author), Massachusetts Gen Hosp, Dept Radiat Oncol, 100 Blossom St, Boston, MA 02114 USA. EM LGerweck@mgh.harvard.edu FU Federal Share/NCI Proton Beam Program Income [NIH C06 CA059267] FX Supported by Federal Share/NCI Proton Beam Program Income, NIH C06 CA059267 (L.E. Gerweck), and in part by Federal Share/NCI Proton Beam Program Income (P. Huang). NR 26 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-8140 J9 RADIOTHER ONCOL JI Radiother. Oncol. PD OCT PY 2014 VL 113 IS 1 BP 146 EP 149 DI 10.1016/j.radonc.2014.09.006 PG 4 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA AY5IB UT WOS:000347604800024 PM 25284063 ER PT J AU Chan, BT Weiser, SD Boum, Y Siedner, MJ Mocello, AR Haberer, JE Hunt, PW Martin, JN Mayer, KH Bangsberg, DR Tsai, AC AF Chan, Brian T. Weiser, Sheri D. Boum, Yap Siedner, Mark J. Mocello, A. R. Haberer, Jessica E. Hunt, Peter W. Martin, Jeffrey N. Mayer, Kenneth H. Bangsberg, David R. Tsai, Alexander C. TI Persistent HIV-related Stigma in Rural Uganda during a Period of Increasing HIV Incidence SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Chan, Brian T.; Siedner, Mark J.; Haberer, Jessica E.; Bangsberg, David R.; Tsai, Alexander C.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Chan, Brian T.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Weiser, Sheri D.; Mocello, A. R.; Hunt, Peter W.; Martin, Jeffrey N.] UCSF, San Francisco, CA USA. [Boum, Yap] Epictr, Mbarara, Uganda. [Mayer, Kenneth H.] Fenway Hlth, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P43.11 BP A259 EP A259 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774403121 ER PT J AU Corleis, B Lisanti, A Korner, C Amero, MA Rosenberg, ES Allen, TM Altfeld, M Kwon, DS AF Corleis, Bjorn Lisanti, Antonella Korner, Christian Amero, Molly A. Rosenberg, Eric S. Allen, Todd M. Altfeld, Marcus Kwon, Douglas S. TI Protective Role of TLR3 Induced Human Beta Defensins during Acute HIV-1 Infection SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Corleis, Bjorn; Lisanti, Antonella; Korner, Christian; Amero, Molly A.; Allen, Todd M.; Altfeld, Marcus; Kwon, Douglas S.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. [Rosenberg, Eric S.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Altfeld, Marcus] Leibniz Inst Expt Virol, Heinrich Pette Inst, Hamburg, Germany. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P12.03 BP A124 EP A125 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774401120 ER PT J AU Dahlke, C Angin, M Muller, C Sharma, S Bhasin, MK Zhuang, Y Addo, MM AF Dahlke, Christine Angin, Mathieu Mueller, Christian Sharma, Siddharta Bhasin, Manoj K. Zhuang, Yan Addo, Marylyn M. TI A Distinct Treg Transcriptome Signature in HIV-1 Elite Controllers Might Contribute to Improved Disease Outcome SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Dahlke, Christine; Addo, Marylyn M.] Univ Klinikum Hamburg Eppendorf, Dept Med, Hamburg, Germany. [Angin, Mathieu; Sharma, Siddharta; Zhuang, Yan] Ragon Inst MIT MGH & Harvard, Boston, MA USA. [Angin, Mathieu] Inst Pasteur, Paris, France. [Mueller, Christian] Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany. [Bhasin, Manoj K.] Beth Israel Deaconess Med Ctr, Genom & Prote Core, Boston, MA 02215 USA. [Addo, Marylyn M.] German Ctr Infect Res, Hamburg, Germany. [Addo, Marylyn M.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P24.18 BP A180 EP A180 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402094 ER PT J AU Gamble, T Stanton, J Greene, E Taylor, J Pack, AP Shelus, V Tolley, EE Brown, ST El-Sadr, W AF Gamble, Theresa Stanton, Jill Greene, Elizabeth Taylor, Jamilah Pack, Allison P. Shelus, Victoria Tolley, Elizabeth E. Brown, Sheldon T. El-Sadr, Wafaa CA HPTN 065 Study Team TI Unanticipated Impact of Financial Incentives on HIV Patients and Providers: Findings from a Qualitative Substudy (HPTN 065) SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Gamble, Theresa; Stanton, Jill; Greene, Elizabeth; Taylor, Jamilah; Pack, Allison P.; Shelus, Victoria; Tolley, Elizabeth E.] FHI 360, Durham, NC USA. [Brown, Sheldon T.] James J Peters VA Med Ctr, Bronx, NY USA. [El-Sadr, Wafaa] Columbia Univ, Mailman Sch Publ Hlth, ICAP, New York, NY USA. [El-Sadr, Wafaa] Harlem Hosp Med Ctr, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P06.02 BP A104 EP A104 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774401067 ER PT J AU Heffron, R Celum, C Mugo, N Katabira, E Bukusi, E Asiimwe, S Ngure, K Bulya, N Odoyo, J Tindimwebwa, E Donnell, D Haberer, JE Kidoguchi, L Morton, J Baeten, JM AF Heffron, Renee Celum, Connie Mugo, Nelly Katabira, Elly Bukusi, Elizabeth Asiimwe, Stephen Ngure, Kenneth Bulya, Nulu Odoyo, Josephine Tindimwebwa, Edna Donnell, Deborah Haberer, Jessica E. Kidoguchi, Lara Morton, Jennifer Baeten, Jared M. CA Partners Demonstration Project TI High Initiation and Adherence among High Risk African HIV Discordant Couples in a Demonstration Project of PrEP and ART for HIV Prevention SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Heffron, Renee; Celum, Connie; Kidoguchi, Lara; Morton, Jennifer; Baeten, Jared M.] Univ Washington, Seattle, WA 98195 USA. [Mugo, Nelly; Bukusi, Elizabeth; Odoyo, Josephine] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Katabira, Elly; Bulya, Nulu] Makerere Univ, Kampala, Uganda. [Asiimwe, Stephen; Tindimwebwa, Edna] KCRC, Kabwohe, Uganda. [Ngure, Kenneth] Jomo Kenyatta Univ Agr & Technol, Nairobi, Kenya. [Donnell, Deborah] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Haberer, Jessica E.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA28.01 BP A71 EP A72 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400162 ER PT J AU Kaida, A Kastner, J Ng, C Sanyu, N Kusasira, A Kabakyenga, J Bangsberg, DR Matthews, LT AF Kaida, Angela Kastner, Jasmine Ng, Courtney Sanyu, Naomi Kusasira, Adrine Kabakyenga, Jerome Bangsberg, David R. Matthews, Lynn T. TI Barriers and Promoters to Uptake of Safer Conception Strategies among HIV-serodiscordant Couples with Fertility Intention in Mbarara, Uganda SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Kaida, Angela; Kastner, Jasmine] Simon Fraser Univ, Fac Hlth Sci, Vancouver, BC, Canada. [Ng, Courtney] Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA 02114 USA. [Sanyu, Naomi; Kusasira, Adrine; Kabakyenga, Jerome; Bangsberg, David R.] Mbarara Univ Sci & Technol, Mbarara, Uganda. [Bangsberg, David R.; Matthews, Lynn T.] MGH Ctr Global Hlth, Boston, MA USA. [Bangsberg, David R.; Matthews, Lynn T.] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA23.03 BP A61 EP A62 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400136 ER PT J AU Laher, F Ranasinghe, S Porichis, F Davis, I Mavrothalassitis, O Ismail, N Mewalal, N Mahungela, S Walker, BD Ndung'u, T Ndhlovu, ZM AF Laher, Faatima Ranasinghe, Srinika Porichis, Filippos Davis, Isaiah Mavrothalassitis, Orestes Ismail, Nasreen Mewalal, Nikoshia Mahungela, Sannie Walker, Bruce D. Ndung'u, Thumbi Ndhlovu, Zaza M. TI Differences in Immunodominant Patterns and HLA-DRB1 Restriction Characteristics in HIV-specific CD4 T-cell Responses between Clade B and C Infection SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Laher, Faatima; Ismail, Nasreen; Mewalal, Nikoshia; Mahungela, Sannie; Ndung'u, Thumbi; Ndhlovu, Zaza M.] Univ KwaZulu Natal, Doris Duke Med Res Inst, HIV Pathogenesis Programme, Durban, South Africa. [Ranasinghe, Srinika; Porichis, Filippos; Davis, Isaiah; Mavrothalassitis, Orestes; Walker, Bruce D.; Ndung'u, Thumbi; Ndhlovu, Zaza M.] Massachusetts Gen Hosp, Ragon Inst MGH MIT & Harvard, Boston, MA 02114 USA. [Ranasinghe, Srinika; Porichis, Filippos; Davis, Isaiah; Mavrothalassitis, Orestes; Walker, Bruce D.; Ndung'u, Thumbi; Ndhlovu, Zaza M.] Harvard Univ, Sch Med, Boston, MA USA. [Walker, Bruce D.] Howard Hughes Med Inst, Chevy Chase, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P24.10 BP A177 EP A177 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402086 ER PT J AU Lee, GQ Carlson, J Brumme, CJ Byakwaga, H Muzoora, C MacMillan, D Kinloch, N Cobarrubias, K Brockman, MA Hunt, PW Martin, JN Carrington, M Bangsberg, DR Harrigan, PR Brumme, ZL AF Lee, Guinevere Q. Carlson, Jonathan Brumme, Chanson J. Byakwaga, Helen Muzoora, Conrad MacMillan, Daniel Kinloch, Natalie Cobarrubias, Kyle Brockman, Mark A. Hunt, Peter W. Martin, Jeff N. Carrington, Mary Bangsberg, David R. Harrigan, P. Richard Brumme, Zabrina L. TI Subtype-Specific HIV-1 Adaptation to Host HLA SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Lee, Guinevere Q.; Brumme, Chanson J.; Brockman, Mark A.; Harrigan, P. Richard; Brumme, Zabrina L.] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada. [Carlson, Jonathan] Microsoft Res, Seattle, WA USA. [Byakwaga, Helen; Muzoora, Conrad] Mbarara Univ Sci & Technol, Mbarara, Uganda. [Byakwaga, Helen; Hunt, Peter W.; Martin, Jeff N.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [MacMillan, Daniel; Kinloch, Natalie; Cobarrubias, Kyle; Brockman, Mark A.; Brumme, Zabrina L.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada. [Carrington, Mary] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA. [Bangsberg, David R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bangsberg, David R.] Harvard Univ, Sch Med, Boston, MA USA. [Harrigan, P. Richard] Univ British Columbia, Dept Med, Vancouver, BC, Canada. RI Lee, Guinevere/D-4436-2017 OI Lee, Guinevere/0000-0002-9412-886X NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P37.03 BP A218 EP A218 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774403014 ER PT J AU Mabuka, JK Dugast, AS Euler, Z Ramlakhan, Y Dong, K Walker, BD Ndung'u, T Alter, G AF Mabuka, Jennifer K. Dugast, Anne-Sophie Euler, Zelda Ramlakhan, Yathisha Dong, Krista Walker, Bruce D. Ndung'u, Thumbi Alter, Galit TI Acute HIV-1 Subtype C Infection Is Associated with Rapid Increase of Tissue-like Memory and Decrease in Resting Memory B-cells SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Mabuka, Jennifer K.; Ndung'u, Thumbi] Univ KwaZulu Natal, KwaZulu Natal Res Inst TB & HIV, Durban, South Africa. [Mabuka, Jennifer K.; Ramlakhan, Yathisha; Walker, Bruce D.; Ndung'u, Thumbi] HIV Pathogenesis Programme, Durban, South Africa. [Dugast, Anne-Sophie; Euler, Zelda; Dong, Krista; Walker, Bruce D.; Ndung'u, Thumbi; Alter, Galit] Massachusetts Gen Hosp, Ragon Inst MGH MIT & Harvard, Boston, MA 02114 USA. [Dugast, Anne-Sophie; Euler, Zelda; Dong, Krista; Walker, Bruce D.; Ndung'u, Thumbi; Alter, Galit] Harvard Univ, Sch Med, Boston, MA USA. [Walker, Bruce D.] Massachusetts Gen Hosp, Boston, MA 02114 USA. RI Dugast, AnneSophie/L-9541-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P34.12 LB BP A211 EP A211 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402174 ER PT J AU Magidson, JF Biello, KB Safren, SA Rosenberger, JG Novak, DS Mayer, KH Mimiaga, MJ AF Magidson, Jessica F. Biello, Katie B. Safren, Steven A. Rosenberger, Joshua G. Novak, David S. Mayer, Kenneth H. Mimiaga, Matthew J. TI HIV Care Continuum among MSM in Latin America Using Online Sexual Networking: Is Engagement in Care Related to Sexual Risk-taking? SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Magidson, Jessica F.; Safren, Steven A.; Mimiaga, Matthew J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Biello, Katie B.; Safren, Steven A.; Mayer, Kenneth H.; Mimiaga, Matthew J.] Fenway Inst, Boston, MA USA. [Biello, Katie B.; Mimiaga, Matthew J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Rosenberger, Joshua G.] George Mason Univ, Dept Global & Community Hlth, Fairfax, VA 22030 USA. [Novak, David S.] Online Buddies Inc, OLB Res Inst, Cambridge, MA USA. [Mayer, Kenneth H.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P08.03 BP A109 EP A109 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774401080 ER PT J AU Martin-Gayo, E Hickman, T Ouyang, ZY Cubas, R Lindqvist, M Kauffman, D Haddad, E Walker, B Lichterfeld, M Yu, XG AF Martin-Gayo, Enrique Hickman, Taylor Ouyang, Zhengyu Cubas, Rafael Lindqvist, Madelene Kauffman, Daniel Haddad, Elias Walker, Bruce Lichterfeld, Mathias Yu, Xu G. TI Dendritic Cells from HIV-1 Neutralizers Efficiently Induce the Generation of CXCR5(+) CXCR3(+) PD1(Lo) CD4 T Cells with B Cell Helper Function SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Martin-Gayo, Enrique; Hickman, Taylor; Ouyang, Zhengyu; Lindqvist, Madelene; Kauffman, Daniel; Walker, Bruce; Yu, Xu G.] Ragon Inst MIT MGH & Harvard, Boston, MA USA. [Cubas, Rafael; Haddad, Elias] Vaccine & Gene Therapy Inst VGTI Florida, Port St Lucie, FL USA. [Walker, Bruce] Howard Hughes Med Inst, Boston, MA 02115 USA. [Lichterfeld, Mathias] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA29.01 BP A74 EP A74 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400167 ER PT J AU Mayer, KH Oldenburg, C Novak, DS Krakower, D Mimiaga, MJ AF Mayer, Kenneth H. Oldenburg, Catie Novak, David S. Krakower, Douglas Mimiaga, Matthew J. TI Differences in PrEP Knowledge and Use in US MSM Users of a Popular Sexual Networking Site Surveyed in August 2013 and January 2014 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Mayer, Kenneth H.; Krakower, Douglas; Mimiaga, Matthew J.] Fenway Hlth, Boston, MA USA. [Mayer, Kenneth H.; Krakower, Douglas; Mimiaga, Matthew J.] Harvard Univ, Fenway Inst, Boston, MA 02115 USA. [Mayer, Kenneth H.; Krakower, Douglas] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA. [Oldenburg, Catie] Fenway Hlth, Fenway Inst, Boston, MA USA. [Oldenburg, Catie; Mimiaga, Matthew J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Novak, David S.] On Line Buddies, On Line Buddies Res Inst, Cambridge, MA USA. [Mimiaga, Matthew J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA PD06.04 LB BP A91 EP A92 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774401039 ER PT J AU Mayer, KH Safren, S Haberer, J Elsesser, S Clarke, W Hendrix, CW Marzinke, M Mimiaga, MJ AF Mayer, Kenneth H. Safren, Steven Haberer, Jessica Elsesser, Steven Clarke, William Hendrix, Craig W. Marzinke, Mark Mimiaga, Matthew J. TI Project PrEPARE: High Levels of Medication Adherence with Continued Condomless Sex in US Men who Have Sex with Men in an Oral PrEP Adherence Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Mayer, Kenneth H.; Safren, Steven; Elsesser, Steven; Mimiaga, Matthew J.] Fenway Hlth, Fenway Inst, Boston, MA USA. [Mayer, Kenneth H.] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA. [Mayer, Kenneth H.; Safren, Steven; Haberer, Jessica] Harvard Univ, Sch Med, Boston, MA USA. [Safren, Steven; Haberer, Jessica; Mimiaga, Matthew J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Clarke, William; Hendrix, Craig W.; Marzinke, Mark] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Mimiaga, Matthew J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA07.06 LB BP A23 EP A24 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400043 ER PT J AU Mayer, KH Gregor, C Gelman, M Grasso, C Melbourne, K Mimiaga, MJ AF Mayer, Kenneth H. Gregor, Charles Gelman, Marcy Grasso, Chris Melbourne, Kathy Mimiaga, Matthew J. TI Safety and Tolerability of Co-formulated Tenofovir/Emtricitabine/Elvitegravir/Cobicistat ("Quad") for Non-occupational Post-exposure Prophylaxis SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Mayer, Kenneth H.; Gregor, Charles; Gelman, Marcy; Grasso, Chris; Mimiaga, Matthew J.] Fenway Hlth, Boston, MA USA. [Mayer, Kenneth H.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Mayer, Kenneth H.] Harvard Univ, Sch Med, Boston, MA USA. [Melbourne, Kathy] Gilead Sci Inc, Clin Res & Educ, Foster City, MA USA. [Mimiaga, Matthew J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Mimiaga, Matthew J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P17.01 BP A155 EP A155 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402028 ER PT J AU Oldenburg, C Perez-Brumer, A Hatzenbuehler, M Krakower, D Novak, D Mimiaga, M Mayer, K AF Oldenburg, Catherine Perez-Brumer, Amaya Hatzenbuehler, Mark Krakower, Douglas Novak, David Mimiaga, Matthew Mayer, Kenneth TI Structural Stigma Affects Access to Pre- and Post-exposure Prophylaxis and HIV Risk among Men Who Have Sex with Men (MSM) in the United States SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Oldenburg, Catherine; Mimiaga, Matthew] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Perez-Brumer, Amaya; Hatzenbuehler, Mark] Columbia Univ, Mailman Sch Publ Hlth, Dept Sociomed Sci, New York, NY USA. [Krakower, Douglas; Mayer, Kenneth] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Novak, David] OLB Res Inst, Cambridge, MA USA. [Mimiaga, Matthew; Mayer, Kenneth] Fenway Inst, Boston, MA USA. [Mimiaga, Matthew] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Mayer, Kenneth] Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA. NR 0 TC 1 Z9 1 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA07.04 BP A22 EP A23 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400041 ER PT J AU Pancera, M Druz, A Zhou, TQ O'Dell, S Louder, M Madani, N Herschhorn, A Sodroski, J Mascola, JR Kwong, PD AF Pancera, Marie Druz, Aliaksandr Zhou, Tongqing O'Dell, Sijy Louder, Mark Madani, Navid Herschhorn, Alon Sodroski, Joseph Mascola, John R. Kwong, Peter D. TI Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Pancera, Marie; Druz, Aliaksandr; Zhou, Tongqing; O'Dell, Sijy; Louder, Mark; Mascola, John R.; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Madani, Navid; Herschhorn, Alon; Sodroski, Joseph] Dana Farber Canc Inst, Boston, MA 02115 USA. RI Zhou, Tongqing/A-6880-2010 OI Zhou, Tongqing/0000-0002-3935-4637 NR 0 TC 2 Z9 2 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P15.28 LB BP A151 EP A151 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402018 ER PT J AU Psaros, C Mosery, N Smit, JA Luthuli, F Gordon, JR Greener, R Bennett, K Bangsberg, DR Safren, SA AF Psaros, Christina Mosery, Nzwakie Smit, Jennifer A. Luthuli, Faith Gordon, Janna R. Greener, Ross Bennett, Kara Bangsberg, David R. Safren, Steven A. TI PMTCT Adherence in Pregnant South African Women: The Role of Depression, Social Support, Stigma and Structural Barriers to Care SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Psaros, Christina; Safren, Steven A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Mosery, Nzwakie; Smit, Jennifer A.; Luthuli, Faith; Greener, Ross] MatCH Res Maternal Adolescent & Child Hlth Res, Durban, South Africa. [Gordon, Janna R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bennett, Kara] Bennett Stat Consulting Inc, Ballston Lake, NY USA. [Bangsberg, David R.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Global Hlth, Boston, MA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA23.02 BP A61 EP A61 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400135 ER PT J AU Tully, DC Ogilvie, CB Batorsky, R Power, KA Bedard, H Seese, A Amero, M Bazner, S Tinsley, J Lennon, NJ Henn, MR Rosenberg, E Mayer, KH Jessen, H Altfeld, M Allen, TM AF Tully, Damien C. Ogilvie, Colin B. Batorsky, Rebecca Power, Karen A. Bedard, Hunter Seese, Aaron Amero, Molly Bazner, Sue Tinsley, Jake Lennon, Niall J. Henn, Matthew R. Rosenberg, Eric Mayer, Kenneth H. Jessen, Heiko Altfeld, Marcus Allen, Todd M. TI Genetic Footprints within the HIV-1 Envelope Glycoprotein Associated with Transmission in Men Who Have Sex with Men SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Tully, Damien C.; Ogilvie, Colin B.; Batorsky, Rebecca; Power, Karen A.; Bedard, Hunter; Seese, Aaron; Amero, Molly; Altfeld, Marcus; Allen, Todd M.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. [Bazner, Sue; Rosenberg, Eric] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Tinsley, Jake; Mayer, Kenneth H.] Fenway Hlth, Fenway Inst, Boston, MA USA. [Lennon, Niall J.; Henn, Matthew R.] Broad Inst MIT & Harvard, Cambridge, MA USA. [Jessen, Heiko] Jessen, HIV Clin Praxis, Berlin, Germany. [Altfeld, Marcus] Heinrich Pette Inst, Hamburg, Germany. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA21.05 BP A57 EP A57 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400126 ER PT J AU Liu, LB Shastry, S Byan-Parker, S Houser, G Chu, KK Birket, SE Fernandez, CM Gardecki, JA Grizzle, WE Wilsterman, EJ Sorscher, EJ Rowe, SM Tearney, GJ AF Liu, Linbo Shastry, Suresh Byan-Parker, Suzanne Houser, Grace Chu, Kengyeh K. Birket, Susan E. Fernandez, Courtney M. Gardecki, Joseph A. Grizzle, William E. Wilsterman, Eric J. Sorscher, Eric J. Rowe, Steven M. Tearney, Guillermo J. TI An Autoregulatory Mechanism Governing Mucociliary Transport Is Sensitive to Mucus Load SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY LA English DT Article DE cilia; micro-optical coherence tomography; intracellular calcium; mucociliary transport ID OPTICAL COHERENCE TOMOGRAPHY; SEA-URCHIN SPERM; ELASTASE-TREATED AXONEMES; CILIARY BEAT FREQUENCY; TRPV4 CHANNEL; PERICILIARY LIQUID; EPITHELIAL-CELLS; AIRWAY EPITHELIA; DYNEIN ACTIVITY; PARAMECIUM AB Mucociliary clearance, characterized by mucus secretion and its conveyance by ciliary action, is a fundamental physiological process that plays an important role in host defense. Although it is known that ciliary activity changes with chemical and mechanical stimuli, the autoregulatory mechanisms that govern ciliary activity and mucus transport in response to normal and pathophysiological variations in mucus are not clear. We have developed a high-speed, 1-mu m resolution, cross-sectional imaging modality, termed micro-optical coherence tomography (mu OCT), which provides the first integrated view of the functional microanatomy of the epithelial surface. We monitored invasion of the periciliary liquid (PCL) layer by mucus in fully differentiated human bronchial epithelial cultures and full thickness swine trachea using mOCT. We further monitored mucociliary transport (MCT) and intracellular calcium concentration simultaneously during invasion of the PCL layer by mucus using colocalized mOCT and confocal fluorescence microscopy in cell cultures. Ciliary beating and mucus transport are up-regulated via a calcium-dependent pathway when mucus causes a reduction in the PCL layer and cilia height. When the load exceeds a physiological limit of approximately 2 mm, this gravity-independent autoregulatory mechanism can no longer compensate, resulting in diminished ciliary motion and abrogation of stimulated MCT. A fundamental integrated mechanism with specific operating limits governs MCT in the lung and fails when periciliary layer compression and mucus viscosity exceeds normal physiologic limits. C1 [Liu, Linbo; Chu, Kengyeh K.; Gardecki, Joseph A.; Tearney, Guillermo J.] Harvard Univ, Sch Med, Wellman Ctr Photomed, Boston, MA USA. [Liu, Linbo; Gardecki, Joseph A.; Wilsterman, Eric J.] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA. [Tearney, Guillermo J.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Shastry, Suresh; Sorscher, Eric J.; Rowe, Steven M.] Univ Alabama Birmingham, Cyst Fibrosis Res Ctr, Birmingham, AL USA. [Byan-Parker, Suzanne; Grizzle, William E.] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Birket, Susan E.; Fernandez, Courtney M.; Sorscher, Eric J.; Rowe, Steven M.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Sorscher, Eric J.; Rowe, Steven M.] Univ Alabama Birmingham, Dept Cell Dev & Integrat Physiol, Birmingham, AL USA. [Houser, Grace; Rowe, Steven M.] Univ Alabama Birmingham, Dept Pediat, Birmingham, AL USA. [Tearney, Guillermo J.] Harvard Massachusetts Inst Technol Hlth Sci & Tec, Cambridge, MA USA. RP Tearney, GJ (reprint author), 55 Fruit St BHX 604, Boston, MA 02114 USA. EM gtearney@partners.org FU National Institute of Health (NIH) [R01 HL1116213, R01 HL105487, P30 DK072482]; Cystic Fibrosis Foundation [R464-CF, SORSCH05XX0, ROWE10XX0, CLANCY09Y2, TEARNE07XX0]; Massachusetts General Hospital ECOR [2011A052538]; University of Alabama at Birmingham Center for Clinical and Translational Science (NIH) [UUL1025777] FX This work was supported by National Institute of Health (NIH) grants R01 HL1116213 (S.M.R. and G.J.T.), R01 HL105487 (S.M.R.), and P30 DK072482 (E.J.S.), Cystic Fibrosis Foundation grants R464-CF and SORSCH05XX0 (E.J.S.), ROWE10XX0 and CLANCY09Y2 (S.M.R.), and TEARNE07XX0 (G.J.T.), and Massachusetts General Hospital ECOR Postdoctoral Fellowship Award 2011A052538, as well as infrastructural support provided by the University of Alabama at Birmingham Center for Clinical and Translational Science (NIH contract UUL1025777). NR 36 TC 20 Z9 20 U1 3 U2 15 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1044-1549 EI 1535-4989 J9 AM J RESP CELL MOL JI Am. J. Respir. Cell Mol. Biol. PD OCT PY 2014 VL 51 IS 4 BP 485 EP 493 DI 10.1165/rcmb.2013-0499MA PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System GA AY2KK UT WOS:000347418700003 PM 24937762 ER PT J AU LaFemina, MJ Sutherland, KM Bentley, T Gonzales, LW Allen, L Chapin, CJ Rokkam, D Sweerus, KA Dobbs, LG Ballard, PL Frank, JA AF LaFemina, Michael J. Sutherland, Katherine M. Bentley, Trevor Gonzales, Linda W. Allen, Lennell Chapin, Cheryl J. Rokkam, Deepti Sweerus, Kelly A. Dobbs, Leland G. Ballard, Philip L. Frank, James A. TI Claudin-18 Deficiency Results in Alveolar Barrier Dysfunction and Impaired Alveologenesis in Mice SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY LA English DT Article DE claudins; tight junctions; bronchopulmonary dysplasia; lung injury ID CHRONIC LUNG-DISEASE; TIGHT JUNCTION STRANDS; BRONCHOPULMONARY DYSPLASIA; EPITHELIAL-CELLS; II CELLS; EXPRESSION; GENE; FIBROSIS; PROTEIN; INJURY AB Claudins are a family of transmembrane proteins that are required for tight junction formation. Claudin (CLDN)-18.1, the only known lung-specific tight junction protein, is the most abundant claudin in alveolar epithelial type (AT) 1 cells, and is regulated by lung maturational agonists and inflammatory mediators. To determine the function of CLDN18 in the alveolar epithelium, CLDN18 knockout (KO) mice were generated and studied by histological, biochemical, and physiological approaches, in addition to whole-genome microarray. Alveolar epithelial barrier function was assessed after knockdown of CLDN18 in isolated lung cells. CLDN18 levels were measured by quantitative PCR in lung samples from fetal and postnatal human infants. We found that CLDN18 deficiency impaired alveolar epithelial barrier function in vivo and in vitro, with evidence of increased paracellular permeability and architectural distortion at AT1-AT1 cell junctions. Although CLDN18 KO mice were born without evidence of a lung abnormality, histological and gene expression analysis at Postnatal Day 3 and Week 4 identified impaired alveolarization. CLDN18 KO mice also had evidence of postnatal lung injury, including acquired AT1 cell damage. Human fetal lungs at 23-24 weeks gestational age, the highest-risk period for developing bronchopulmonary dysplasia, a disease of impaired alveolarization, had significantly lower CLDN18 expression relative to postnatal lungs. Thus, CLDN18 deficiency results in epithelial barrier dysfunction, injury, and impaired alveolarization in mice. Low expression of CLDN18 in human fetal lungs supports further investigation into a role for this tight junction protein in bronchopulmonary dysplasia. C1 [LaFemina, Michael J.; Sutherland, Katherine M.; Sweerus, Kelly A.; Dobbs, Leland G.; Frank, James A.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Allen, Lennell; Chapin, Cheryl J.; Dobbs, Leland G.; Ballard, Philip L.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA. [LaFemina, Michael J.; Frank, James A.] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Bentley, Trevor; Rokkam, Deepti; Frank, James A.] Northern Calif Inst Res & Educ, San Francisco, CA USA. [Gonzales, Linda W.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA. RP LaFemina, MJ (reprint author), San Francisco VA Med Ctr, 4150 Clement St,Box 111D, San Francisco, CA 94121 USA. EM michael.lafemina@ucsf.edu FU Fisher Fellowship within the Nina Ireland Lung Disease Program; T32 Multidisciplinary Training Program in Lung Diseases [HL007185]; Sandler Asthma Basic Research Center Functional Genomics Core Facility; National Institutes of Health (NIH)/National Center for Research Resources University of California San Francisco-Clinical & Translational Science Institute [UL1 RR024131]; NIH [U01HG004085]; [HL088440]; [K08HL116647]; [HL24075] FX This work was supported by HL088440 (J.A.F.), K08HL116647 (M.J.L.), HL24075 (P.L.B., L.G.D.), a Parker B. Francis Fellowship (M.J.L.), the Fisher Fellowship within the Nina Ireland Lung Disease Program (M.J.L.), and T32 Multidisciplinary Training Program in Lung Diseases HL007185 (K.M.S.). Microarray work was supported in part by the Sandler Asthma Basic Research Center Functional Genomics Core Facility and National Institutes of Health (NIH)/National Center for Research Resources University of California San Francisco-Clinical & Translational Science Institute grant UL1 RR024131. NIH grants to Velocigene at Regeneron Inc. (U01HG004085) and the CSD Consortium of Children's Hospital Oakland Research Institute (CHORI), Sanger Institute, and University of California Davis (U01HG004080) funded the generation of gene-targeted ES cells for 8,500 genes in the trans-NIH Knock-Out Mouse Project (KOMP) Program and archived and distributed by the KOMP Repository at University of California Davis and CHORI (U42RR024244). NR 42 TC 15 Z9 15 U1 0 U2 3 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1044-1549 EI 1535-4989 J9 AM J RESP CELL MOL JI Am. J. Respir. Cell Mol. Biol. PD OCT PY 2014 VL 51 IS 4 BP 550 EP 558 DI 10.1165/rcmb.2013-0456OC PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System GA AY2KK UT WOS:000347418700009 PM 24787463 ER PT J AU Ananthakrishnan, A Cagan, A Cai, TX Gainer, V Shaw, S Churchill, S Karlsin, E Murphy, S Kohane, I Liao, K AF Ananthakrishnan, Ashwin Cagan, Andrew Cai, Tianxi Gainer, Vivian Shaw, Stanley Churchill, Susanne Karlsin, Elizabeth Murphy, Shawn Kohane, Isaac Liao, Katherine TI Colonoscopy Is Associated With a Reduced Risk of Colon Cancer and Mortality in Patients With Inflammatory Bowel Diseases SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Ananthakrishnan, Ashwin; Shaw, Stanley; Murphy, Shawn] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA. [Karlsin, Elizabeth; Kohane, Isaac; Liao, Katherine] Brigham & Womens Hosp, Boston, MA 02115 USA. [Cai, Tianxi] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Cagan, Andrew; Gainer, Vivian; Churchill, Susanne] Partners Healthcare, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 2202 BP S639 EP S639 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102556 ER PT J AU Ananthakrishnan, A Cagan, A Gainer, V Cai, TX Shaw, S Churchill, S Karlsin, E Murphy, S Kohane, I Liao, K AF Ananthakrishnan, Ashwin Cagan, Andrew Gainer, Vivian Cai, Tianxi Shaw, Stanley Churchill, Susanne Karlsin, Elizabeth Murphy, Shawn Kohane, Isaac Liao, Katherine TI Mode of Childbirth and Long-term Outcomes in Women With Inflammatory Bowel Diseases SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Ananthakrishnan, Ashwin; Shaw, Stanley; Murphy, Shawn] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA. [Cai, Tianxi] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Karlsin, Elizabeth; Kohane, Isaac; Liao, Katherine] Brigham & Womens Hosp, Boston, MA 02115 USA. [Cagan, Andrew; Gainer, Vivian; Churchill, Susanne] Partners Healthcare, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1608 BP S474 EP S474 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102004 ER PT J AU Anderson, J Lisovsky, M Greene, MA Hagen, C Srivastava, A AF Anderson, Joseph Lisovsky, Mikhail Greene, Mary Ann Hagen, Catherine Srivastava, Amitabh TI Large (>5 mm) Hyperplastic Polyps That Are Proximal to the Sigmoid Are More Likely to Be Reclassified as Sessile Serrated Adenomas/Polyps SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Anderson, Joseph] White River Junction VAMC, White River Jct, VT USA. [Lisovsky, Mikhail] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Srivastava, Amitabh] Brigham & Womens Hosp, Boston, MA 02115 USA. [Greene, Mary Ann] Dartmouth Coll, Hanover, NH 03755 USA. [Hagen, Catherine] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 2080 BP S612 EP S612 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102462 ER PT J AU Barshop, K Dukes, G Barton, M Semler, J Kuo, B AF Barshop, Kenneth Dukes, George Barton, Matthew Semler, Jack Kuo, Braden TI Duodenal Rather Than Gastric Motility Parameters Correlate With Symptom Severity in Patients With Diabetic Gastroparesis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Barshop, Kenneth] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA. [Kuo, Braden] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Dukes, George; Barton, Matthew; Semler, Jack] GlaxoSmithKline, Raleigh, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 339 BP S102 EP S102 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100340 ER PT J AU Barshop, K Dukes, G Barton, M Semler, J Kuo, B AF Barshop, Kenneth Dukes, George Barton, Matthew Semler, Jack Kuo, Braden TI An Assessment of Gastric and Small Bowel Pressure Profiles in Diabetics With Gastroparesis Before and During 28 Days of Treatment With the Motilin Receptor Agonist Camicinal (GSK962040) SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Barshop, Kenneth] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA. [Kuo, Braden] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Dukes, George; Barton, Matthew; Semler, Jack] GlaxoSmithKline, Raleigh, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 139 BP S43 EP S44 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100140 ER PT J AU Basu, P Shah, N Aloysius, M Lee, D Gress, F AF Basu, Patrick Shah, Niraj Aloysius, Mark Lee, David Gress, Frank TI Novel Colonoscopy Preparation of Organic Coconut Water With Miralax (R) and Dulcolax (R) in Split Doses for Decompensated Cirrhotics. A Randomized, Double-Blinded, Open-Labelled, Clinical Pilot Single-Centered Observational Study: COSMIC Study SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Basu, Patrick; Gress, Frank] Columbia Sch Phys & Surg, New York, NY USA. [Aloysius, Mark; Lee, David] Kings Cty Hosp Med Ctr, Brooklyn, NY USA. [Shah, Niraj] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1890 BP S560 EP S560 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102285 ER PT J AU Basu, P Shah, N Aloysius, M AF Basu, Patrick Shah, Niraj Aloysius, Mark TI Simeprevir and Sofosbuvir With Modified Doses of Ribavirin (RBV) Therapy on Telaprevir-Experienced, Coinfected (With HIV) Cirrhotics With Chronic Hepatitis C (CHC): A Randomized, Open-Label, Clinical Pilot Study, STOP C, Interim Results SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Basu, Patrick] Columbia Sch Phys & Surg, New York, NY USA. [Aloysius, Mark] Kings Cty Hosp Med Ctr, New York, NY USA. [Shah, Niraj] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 606 BP S177 EP S177 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100599 ER PT J AU Basu, P Shah, N Aloysius, M Brown, R AF Basu, Patrick Shah, Niraj Aloysius, Mark Brown, Robert TI Role of Intravenous N-Acetyl Cysteine (NAC) With Steroids in Acute Alcoholic Hepatitis With High Morbidity Score: A Randomized, Open-Label, Prospective Clinical Trial: Renaissance Trial SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Basu, Patrick; Brown, Robert] Columbia Sch Phys & Surg, New York, NY USA. [Aloysius, Mark] Kings Cty Hosp Med Ctr, New York, NY USA. [Shah, Niraj] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 603 BP S176 EP S176 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100596 ER PT J AU Basu, P Shah, N Aloysius, M Brown, R AF Basu, Patrick Shah, Niraj Aloysius, Mark Brown, Robert TI Trial Role of Mycophenolate Mofetil (MMF) in Steroid Nonresponsive Severe Acute Alcoholic Hepatitis: A Randomized, Open-Label, Placebo-Controlled Prospective Clinical Pilot Trial-MASH SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Basu, Patrick; Brown, Robert] Columbia Sch Phys & Surg, New York, NY USA. [Aloysius, Mark] Kings Cty Hosp Med Ctr, New York, NY USA. [Shah, Niraj] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 602 BP S176 EP S176 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100595 ER PT J AU Basu, P Shah, N Aloysius, M Brown, R AF Basu, Patrick Shah, Niraj Aloysius, Mark Brown, Robert TI Berberine With Alfa Lipoic Acid (ALA) in Non-alcoholic Steatohepatitis: A Randomized Double-Blinded Placebo Control Trial: A Clinical Pilot: The Banish Trial SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Basu, Patrick; Brown, Robert] Columbia Sch Phys & Surg, New York, NY USA. [Aloysius, Mark] Kings Cty Hosp Med Ctr, New York, NY USA. [Shah, Niraj] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 599 BP S175 EP S175 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100592 ER PT J AU Chen, TC Cruz, G Sellin, J Hou, J AF Chen, Tien-Chun Cruz, Guillermina Sellin, Joseph Hou, Jason TI Food Avoidance and Use of Dietary Supplements Among Patients With Inflammatory Bowel Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Chen, Tien-Chun; Cruz, Guillermina] Baylor Coll Med, Houston, TX 77030 USA. [Sellin, Joseph] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA. [Hou, Jason] Baylor Coll Med, Ctr Innovat Qual Effectiveness & Safety IQuESt, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1715 BP S507 EP S507 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102111 ER PT J AU Colussi, D Lauwers, G Richter, J Ricciardiello, L Chan, A Khalili, H AF Colussi, Dora Lauwers, Gregory Richter, James Ricciardiello, Luigi Chan, Andrew Khalili, Hamed TI Lymphocytic Colitis and Collagenous Colitis: Differences in Clinical Characteristics, Treatment Patterns, and Predictors of Response to Treatment SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Colussi, Dora; Lauwers, Gregory; Richter, James; Chan, Andrew; Khalili, Hamed] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Ricciardiello, Luigi] Univ Bologna, Bologna, Italy. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 761 BP S221 EP S221 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100752 ER PT J AU Diamond, S Sonnenberg, A AF Diamond, Sarah Sonnenberg, Amnon TI Game Theory in Repetitive Ingestion of Foreign Bodies SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Diamond, Sarah] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Sonnenberg, Amnon] Portland VA Med Ctr, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 2234 BP S648 EP S648 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102588 ER PT J AU DSouza, S Enestvedt, B Pavic, B Holub, J Rodriguez, S AF DSouza, Sharlene Enestvedt, Brintha Pavic, Brian Holub, Jennifer Rodriguez, Sarah Betsy TI Nationwide Utilization of Endoscopic Ultrasound SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Pavic, Brian; Rodriguez, Sarah Betsy] Oregon Clin West, Portland, OR USA. [Enestvedt, Brintha; Holub, Jennifer] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [DSouza, Sharlene] Portland VA Med Ctr, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1956 BP S579 EP S579 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102351 ER PT J AU Guo, A Wilson, R Stevens, B Russell, C Cohen, M Sturgeon, H Giallourakis, C Khalili, H Nguyen, D Sauk, J Xavier, R Yajnik, V Ananthakrishnan, A AF Guo, Abra Wilson, Robin Stevens, Betsy Russell, Caitlin Cohen, Melissa Sturgeon, Holly Giallourakis, Cosmas Khalili, Hamed Nguyen, Deanna Sauk, Jenny Xavier, Ramnik Yajnik, Vijay Ananthakrishnan, Ashwin TI Early Life Environment and Natural History of Inflammatory Bowel Diseases SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Guo, Abra; Wilson, Robin; Stevens, Betsy; Russell, Caitlin; Cohen, Melissa; Sturgeon, Holly; Giallourakis, Cosmas; Khalili, Hamed; Nguyen, Deanna; Sauk, Jenny; Xavier, Ramnik; Yajnik, Vijay; Ananthakrishnan, Ashwin] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1639 BP S486 EP S486 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102035 ER PT J AU Hashash, J Chedid, V Habib-Bein, N Francis, F AF Hashash, Jana Chedid, Victor Habib-Bein, Nadia Francis, Fadi TI Unusual Cause of Gastric Outlet Obstruction SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Hashash, Jana; Chedid, Victor] Univ Pittsburgh, Med Ctr, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA. [Habib-Bein, Nadia; Francis, Fadi] Vet Affairs Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1157 BP S344 EP S344 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101383 ER PT J AU Jain, V Sharma, D Simeunovic, K Gavrancic, T Jubbal, S Ramasamy, V Anklesaria, A AF Jain, Varun Sharma, Deepak Simeunovic, Kosana Gavrancic, Tatjana Jubbal, Sandeep Ramasamy, Vimala Anklesaria, Ava TI Colon Cancer With Gastric Invasion Resulting in Gastric Outlet Obstruction: An Uncommon Presentation of Locally Advanced Colorectal Cancer That Was Successfully Treated With Surgical Resection SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Jain, Varun; Sharma, Deepak; Simeunovic, Kosana; Gavrancic, Tatjana; Jubbal, Sandeep; Anklesaria, Ava] James J Peters VA Med Ctr, Icahn Sch Med Mt Sinai, Bronx, NY USA. [Ramasamy, Vimala] North Cent Bronx Hosp, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1388 BP S411 EP S411 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101614 ER PT J AU Jain, V Sharma, D Marcus, S Brau, N AF Jain, Varun Sharma, Deepak Marcus, Sonja Brau, Norbert TI Spontaneous Clearance of Chronic HCV Infection: An Unusual Phenomenon SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Jain, Varun; Sharma, Deepak; Marcus, Sonja; Brau, Norbert] James J Peters VA Med Ctr, Icahn Sch Med Mt Sinai Bronx, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1337 BP S392 EP S392 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101563 ER PT J AU Jain, V Sharma, D Gavrancic, T Anklesaria, A Ramasamy, V White, S Iliev, A AF Jain, Varun Sharma, Deepak Gavrancic, Tatjana Anklesaria, Ava Ramasamy, Vimala White, Sherrie Iliev, Andrey TI An Unusual Cause of Partial Small Bowel Obstruction in a Young Male With HTLV-1 SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Ramasamy, Vimala; White, Sherrie; Iliev, Andrey] North Cent Bronx Hosp, Bronx, NY USA. [Jain, Varun; Sharma, Deepak; Gavrancic, Tatjana; Anklesaria, Ava] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1096 BP S325 EP S326 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101322 ER PT J AU Jain, V Sharma, D Ramasamy, V Anklesaria, A Goswami, G AF Jain, Varun Sharma, Deepak Ramasamy, Vimala Anklesaria, Ava Goswami, Gayotri TI A Case of Exenatide-Induced Recurrent Pancreatitis Despite Withdrawl of Drug Therapy SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Jain, Varun; Sharma, Deepak; Anklesaria, Ava] James J Peters VA Med Ctr, Icahn Sch Med Mt Sinai Bronx, Bronx, NY USA. [Ramasamy, Vimala; Goswami, Gayotri] North Cent Bronx Hosp, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 977 BP S291 EP S291 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101209 ER PT J AU Kabbani, T Pallav, K Dowd, S Vanga, R Villafuerte-Galvez, J Castillo, N Kelly, C AF Kabbani, Toufic Pallav, Kumar Dowd, Scot Vanga, Rohini Villafuerte-Galvez, Javier Castillo, Natalia Kelly, Ciaran TI Antibiotic-Associated Microbiome Changes in Healthy Volunteers and Corrective Impact of the Probiotic Saccharomyces boulardii SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Kabbani, Toufic; Kelly, Ciaran] Harvard Univ, Sch Med, Boston, MA USA. [Pallav, Kumar; Vanga, Rohini; Villafuerte-Galvez, Javier; Castillo, Natalia] BIDMC, Boston, MA USA. [Dowd, Scot] MR DNA, Shallowater, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 685 BP S199 EP S199 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100676 ER PT J AU Kadayifci, A Atar, M Wang, J Forcione, D Casey, B Fernandez-del Castillo, C Pitman, M Brugge, W AF Kadayifci, Abdurrahman Atar, Mustafa Wang, Jessica Forcione, David Casey, Brenna Fernandez-del Castillo, Carlos Pitman, Martha Brugge, William TI Pancreas Cyst Fluid KRAS Mutation Is an Accurate Marker for the Diagnosis of a Mucinous Cyst SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Kadayifci, Abdurrahman; Atar, Mustafa; Wang, Jessica; Forcione, David; Casey, Brenna; Fernandez-del Castillo, Carlos; Pitman, Martha; Brugge, William] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 308 BP S94 EP S95 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100309 ER PT J AU Kadayifci, A Atar, M Wang, J Forcione, D Casey, B Pitman, M Brugge, W AF Kadayifci, Abdurrahman Atar, Mustafa Wang, Jessica Forcione, David Casey, Brenna Pitman, Martha Brugge, William TI The Role of GNAS Analyses for Differential Diagnosis of IPMN SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Kadayifci, Abdurrahman; Atar, Mustafa; Wang, Jessica; Forcione, David; Casey, Brenna; Pitman, Martha; Brugge, William] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 293 BP S89 EP S89 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100294 ER PT J AU Kassam, Z Fabersunne, CC Smith, M Kaplan, G Nguyen, G Ananthakrishnan, A AF Kassam, Zain Fabersunne, Camila Cribb Smith, Mark Kaplan, Gilaad Nguyen, Geoffrey Ananthakrishnan, Ashwin TI C. difficile-Associated Risk of Death Score (CARDS): A Novel Risk Score to Predict Mortality Among Hospitalized Patients With C. difficile Infection SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Kassam, Zain; Smith, Mark] MIT, Cambridge, MA 02139 USA. [Fabersunne, Camila Cribb] Harvard Univ, Sch Med, Boston, MA USA. [Kaplan, Gilaad] Univ Calgary, Calgary, AB, Canada. [Nguyen, Geoffrey] Univ Toronto, Toronto, ON, Canada. [Ananthakrishnan, Ashwin] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1603 BP S669 EP S669 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102649 ER PT J AU Kassam, Z Fabersunne, CC Smith, M Kaplan, G Nguyen, G Ananthakrishnan, A AF Kassam, Zain Fabersunne, Camila Cribb Smith, Mark Kaplan, Gilaad Nguyen, Geoffrey Ananthakrishnan, Ashwin TI Racial Disparities in C. difficile Infection SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Kassam, Zain; Smith, Mark] MIT, Cambridge, MA 02139 USA. [Fabersunne, Camila Cribb] Harvard Univ, Sch Med, Boston, MA USA. [Kaplan, Gilaad] Univ Calgary, Calgary, AB, Canada. [Nguyen, Geoffrey] Univ Toronto, Toronto, ON, Canada. [Ananthakrishnan, Ashwin] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1605 BP S669 EP S670 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102651 ER PT J AU Malaty, H Sansgiry, S Hou, J AF Malaty, Hoda Sansgiry, Shubhada Hou, Jason TI Time Trends, Clinical Characteristics, and Risk Factors of Chronic Anal Fissure Among a National Cohort of Patients With Inflammatory Bowel Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Malaty, Hoda; Hou, Jason] Baylor Coll Med, Houston, TX 77030 USA. [Sansgiry, Shubhada] VA Med Ctr, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1625 BP S481 EP S482 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102021 ER PT J AU Rao, BB Click, B Codario, R AF Rao, Bhavana Bhagya Click, Benjamin Codario, Ronald TI Successful Management of Refractory Noninsulinoma Pancreatogenous Hypoglycemia Syndrome With Gastric Bypass Reversal: A Case Report SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Rao, Bhavana Bhagya; Click, Benjamin] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Codario, Ronald] VA Pittsburgh Healthcare Syst, Univ Drive Div, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1037 BP S309 EP S309 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101263 ER PT J AU Sahay, T Ananthakrishnan, A AF Sahay, Tanya Ananthakrishnan, Ashwin TI Low Serum Vitamin D is Associated With Increased Risk of Community-Acquired Clostridium difficile Infection SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Sahay, Tanya; Ananthakrishnan, Ashwin] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 663 BP S191 EP S192 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100654 ER PT J AU Sharma, D Jain, V Jubbal, S Ramasamy, V Anklesaria, A Bogdanovic, Z AF Sharma, Deepak Jain, Varun Jubbal, Sandeep Ramasamy, Vimala Anklesaria, Ava Bogdanovic, Zoran TI Rare Case of End-Stage Gastric Signet Cell Adenocarcinoma that Metastasized to the Colon SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Sharma, Deepak; Jain, Varun; Jubbal, Sandeep; Anklesaria, Ava] Icahn Sch Med Mt Sinai Bronx, James J Peters VA Med Ctr, Bronx, NY USA. [Ramasamy, Vimala; Bogdanovic, Zoran] North Cent Bronx Hosp, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 882 BP S259 EP S259 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101117 ER PT J AU Singh, P Staller, K Barshop, K Dai, E Newman, J Yoon, S Castel, S Kuo, B AF Singh, Prashant Staller, Kyle Barshop, Kenneth Dai, Elaine Newman, Jennifer Yoon, Sonia Castel, Shahar Kuo, Braden TI Patients Sith Diarrhea-Predominant Irritable Bowel Syndrome Have Lower Disease-Specific Quality of Life Than Constipation-Predominant Irritable Bowel Syndrome SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Singh, Prashant; Staller, Kyle; Dai, Elaine; Newman, Jennifer; Castel, Shahar; Kuo, Braden] Massachusetts Gen Hosp, Newton, MA USA. [Yoon, Sonia] Cornell Med Ctr, New York, NY USA. [Barshop, Kenneth] Univ Chicago, Chicago, IL 60637 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1813 BP S536 EP S537 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102208 ER PT J AU Singh, P Arora, S Strand, T Makharia, G AF Singh, Prashant Arora, Shubhangi Strand, Tor Makharia, Govind TI Celiac Disease in Women With Infertility: A Meta-Analysis ACG Radhika Srinivasan Gender-Based Research Award SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Singh, Prashant] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Arora, Shubhangi; Makharia, Govind] All India Inst Med Sci, New Delhi, India. [Strand, Tor] Univ Bergen, Bergen, Norway. NR 0 TC 0 Z9 0 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 350 BP S105 EP S105 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100351 ER PT J AU Sonnenberg, A AF Sonnenberg, Amnon TI Ruling In and Out a Source of Gastrointestinal Bleeding SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Sonnenberg, Amnon] Portland VA Med Ctr, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1864 BP S551 EP S551 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102259 ER PT J AU Sonnenberg, A Turner, K Genta, R AF Sonnenberg, Amnon Turner, Kevin Genta, Robert TI Ethnic Distribution of Microscopic Colitis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Sonnenberg, Amnon] Portland VA Med Ctr, Portland, OR USA. [Turner, Kevin; Genta, Robert] Miraca Life Sci Res Inst, Irving, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 690 BP S200 EP S200 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100681 ER PT J AU Ting, A Cheifetz, A Moss, A AF Ting, Amanda Cheifetz, Adam Moss, Alan TI Non-adherence to Topical Mesalamine in Patients With Ulcerative Colitis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Ting, Amanda; Cheifetz, Adam; Moss, Alan] BIDMC, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1727 BP S511 EP S511 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102123 ER PT J AU Tokunbo, A Nambudiri, N Yang, P AF Tokunbo, Ajayi Nambudiri, Navya Yang, Peter TI An Unusual Cause of a Colonic Mass in a Patient With Crohn's Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Tokunbo, Ajayi; Nambudiri, Navya] Salem Hosp, Salem, MA USA. [Yang, Peter] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1459 BP S432 EP S432 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383101685 ER PT J AU Wang, MH Fiocchi, C Duerr, R Ripke, S Achkar, JP AF Wang, Ming-Hsi Fiocchi, Claudio Duerr, Richard Ripke, Stephan Achkar, Jean-Paul TI A Model Integrating Genetic and Environmental Factors Interactions Can Predict Crohn's Disease Risk SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Wang, Ming-Hsi; Fiocchi, Claudio; Achkar, Jean-Paul] Cleveland Clin, Cleveland, OH 44106 USA. [Duerr, Richard] Univ Pittsburgh, Pittsburgh, PA USA. [Ripke, Stephan] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 2 Z9 2 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1701 BP S503 EP S503 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102097 ER PT J AU Whitman, C Arnold, C Patel, H Scopel, J Martinez, B Reid, M Spiegel, B AF Whitman, Cynthia Arnold, Corey Patel, Haridarshan Scopel, Justin Martinez, Bibiana Reid, Mark Spiegel, Brennan TI Managing Opioid-Induced Constipation: Perceptions and Misconceptions From the Online Community SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Whitman, Cynthia; Martinez, Bibiana] Cedars Sinai Med Ctr CORE, Beverly Hills, CA USA. [Arnold, Corey] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Patel, Haridarshan] Takeda Pharmaceut Int Inc, Global Outcomes & Epidemiol Res, Deerfield, IL USA. [Scopel, Justin] Takeda Pharmaceut Int Inc, US Med Affairs, Deerfield, IL USA. [Reid, Mark] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Spiegel, Brennan] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 2218 BP S643 EP S644 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102572 ER PT J AU Wilson, R Stevens, B Guo, A Cohen, M Sturgeon, H Russell, C Giallourakis, C Khalili, H Nguyen, D Xavier, R Yajnik, V Sauk, J Ananthakrishnan, A AF Wilson, Robin Stevens, Betsy Guo, Abra Cohen, Melissa Sturgeon, Holly Russell, Caitlin Giallourakis, Cosmas Khalili, Hamed Nguyen, Deanna Xavier, Ramnik Yajnik, Vijay Sauk, Jenny Ananthakrishnan, Ashwin TI Elevated C-Reactive Protein is Associated With Poor Sleep Quality in Patients With Inflammatory Bowel Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Wilson, Robin; Stevens, Betsy; Guo, Abra; Cohen, Melissa; Sturgeon, Holly; Russell, Caitlin; Giallourakis, Cosmas; Khalili, Hamed; Nguyen, Deanna; Xavier, Ramnik; Yajnik, Vijay; Sauk, Jenny; Ananthakrishnan, Ashwin] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 1647 BP S488 EP S489 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383102043 ER PT J AU Yen, E Sonnenberg, A Genta, R AF Yen, Eugene Sonnenberg, Amnon Genta, Robert TI Higher Prevalence of Celiac Disease in Patients With Microscopic Colitis: Results From a Large Pathology Database SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 79th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 17-22, 2014 CL Philadelphia, PA SP Amer Coll Gastroenterol C1 [Yen, Eugene] NorthShore Univ HealthSyst, Evanston, IL USA. [Sonnenberg, Amnon] Portland VA Med Ctr, Portland, OR USA. [Genta, Robert] Miraca Life Sci Res Inst, Irving, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2014 VL 109 SU 2 MA 713 BP S207 EP S207 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AS6OR UT WOS:000344383100704 ER PT J AU Xiong, L Yu, J Miao, XY Wen, Y Liu, KJ Wang, FS Yang, ZL Sun, Y AF Xiong, Li Yu, Jane Miao, Xiongying Wen, Yu Liu, Kuijie Wang, Fusheng Yang, Zhulin Sun, Yang TI PROTHYMOSIN AND PARATHYMOSIN a ARE PROGNOSTIC MARKERS IN SC/ASC OF GALLBLADDER SO ANNALS OF ONCOLOGY LA English DT Meeting Abstract CT 12th Annual Meeting of the Japanese-Society-of-Medical-Oncology CY JUL 17-19, 2014 CL Fukuoka, JAPAN SP Japanese Soc Med Oncol C1 [Xiong, Li; Miao, Xiongying; Wen, Yu; Liu, Kuijie; Yang, Zhulin] Second Xiangya Hosp, Changsha, Hunan, Peoples R China. [Yu, Jane; Wang, Fusheng; Sun, Yang] Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Cambridge, MA 02138 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 EI 1569-8041 J9 ANN ONCOL JI Ann. Oncol. PD OCT PY 2014 VL 25 SU 5 MA O2-9-3 DI 10.1093/annonc/mdu435.78 PG 1 WC Oncology SC Oncology GA AX8MN UT WOS:000347163700152 ER PT J AU Arvikar, SL Hasturk, H Bolster, MB Collier, DS Kantarci, A Steere, AC AF Arvikar, Sheila L. Hasturk, Hatice Bolster, Marcy B. Collier, Deborah S. Kantarci, Alpdogan Steere, Allen C. TI Parameters of Periodontitis Correlate with Anti-Citrullinated Protein Antibodies and P. Gingivalis Antibody Titers in Patients with Early or Chronic Rheumatoid Arthritis. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Arvikar, Sheila L.; Bolster, Marcy B.; Collier, Deborah S.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Hasturk, Hatice; Kantarci, Alpdogan] Forsyth Inst, Cambridge, MA USA. [Steere, Allen C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1402 BP S618 EP S619 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903026 ER PT J AU Arvikar, SL Lin, J Kohler, MJ AF Arvikar, Sheila L. Lin, Janice Kohler, Minna J. TI Musculoskeletal Ultrasound Reveals Calcific Deposition Arthropathy in Seronegative Inflammatory Arthritis Patients. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Arvikar, Sheila L.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Lin, Janice] Brigham & Womens Hosp, Boston, MA 02115 USA. [Kohler, Minna J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 183 BP S77 EP S77 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384900184 ER PT J AU Baker, J Conaghan, PG Emery, P Baker, D Ostergaard, M AF Baker, Joshua Conaghan, Philip G. Emery, Paul Baker, Daniel Ostergaard, Mikkel TI Early MRI Endpoints Provide a Valid Measure of Structural Damage While Reducing Study Duration and Participant Numbers in Rheumatoid Arthritis Clinical Trials. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Baker, Joshua] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Conaghan, Philip G.] Univ Leeds, Leeds, W Yorkshire, England. [Conaghan, Philip G.; Emery, Paul] NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England. [Emery, Paul] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England. [Baker, Daniel] Janseen R&D, Spring House, PA USA. Copenhagen Univ Hosp Glostrup, Copenhagen Ctr Arthrit Res, Glostrup, Denmark. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1891 BP S832 EP S832 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904041 ER PT J AU Baker, J Cannon, GW Ibrahim, S Haroldsen, C Caplan, L Mikuls, TR AF Baker, Joshua Cannon, Grant W. Ibrahim, Said Haroldsen, Candace Caplan, Liron Mikuls, Ted R. TI Predictors of Long-Term Changes in Body Mass Index in Rheumatoid Arthritis. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Baker, Joshua] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Cannon, Grant W.] Salt Lake City VA, Salt Lake City, UT USA. [Cannon, Grant W.; Haroldsen, Candace] Univ Utah, Salt Lake City, UT USA. [Ibrahim, Said] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Caplan, Liron] Denver VA, Aurora, CO USA. [Caplan, Liron] Univ Colorado, Sch Med, Aurora, CO USA. [Mikuls, Ted R.] Omaha VA Med Ctr, Omaha, NE USA. [Mikuls, Ted R.] Univ Nebraska Med Ctr, Omaha, NE USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1392 BP S614 EP S614 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903016 ER PT J AU Baker, J Melissa, P Herlyn, K Pizzo, AS Lapey, A Finklestein, J Merkel, PA AF Baker, Joshua Melissa, Putman Herlyn, Karen Pizzo, Angela S. Lapey, Allen Finklestein, Joel Merkel, Peter A. TI Risk Factors for Prevalent and Progressive Bone Deficits Among Adult Men and Women with Cystic Fibrosis. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Baker, Joshua] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Melissa, Putman; Finklestein, Joel] Harvard Univ, Boston, MA 02115 USA. [Herlyn, Karen] Univ Hosp Schleswig Holstein, Lubeck, Germany. [Pizzo, Angela S.] Mercy Hosp, Portland, ME USA. [Lapey, Allen] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Merkel, Peter A.] Univ Penn, Vasc Ctr, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 236 BP S98 EP S99 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384900237 ER PT J AU Battistone, MJ Barker, AM Grotzke, MP Beck, JP Quan, A Hose, M Seligman, V Ravenell, R Pavuluri, P Roberts, WN Pioro, M Fisher, N Osting, V Prihar, B Hackman, J Kirsh, S Cannon, GW AF Battistone, Michael J. Barker, Andrea M. Grotzke, Marissa P. Beck, J. Peter Quan, Anna Hose, Michal Seligman, Victoria Ravenell, Roneka Pavuluri, Pushpa Roberts, W. Neal Pioro, Mathilde Fisher, Nancy Osting, Vanessa Prihar, Betty Hackman, Joanne Kirsh, Susan Cannon, Grant W. TI The Musculoskeletal Mini-Residency Collaborative Network: A National Department of Veterans Affairs Interdisciplinary and Interprofessional Educational Innovation for Primary Care Providers. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Battistone, Michael J.; Barker, Andrea M.; Grotzke, Marissa P.; Beck, J. Peter; Cannon, Grant W.] Salt Lake City VA, Salt Lake City, UT USA. [Battistone, Michael J.; Barker, Andrea M.; Grotzke, Marissa P.; Beck, J. Peter; Cannon, Grant W.] Univ Utah, Salt Lake City, UT USA. [Quan, Anna; Hose, Michal] San Diego VA, San Diego, CA USA. [Seligman, Victoria] Denver VA Med Ctr, Denver, CO USA. [Ravenell, Roneka; Pavuluri, Pushpa; Roberts, W. Neal] Louisville VA, Louisville, KY USA. [Pioro, Mathilde; Fisher, Nancy] Cleveland VA, Cleveland, OH USA. [Osting, Vanessa; Prihar, Betty] Tampa VA, Tampa, FL USA. [Hackman, Joanne; Kirsh, Susan] VHA Cent Off, Patient Care Serv, Off Specialty Care Transformat, Washington, DC USA. RI Beck, James Peter/F-9407-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2001 BP S878 EP S879 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904151 ER PT J AU Berman, N Dunham, JS Baker, J Vivino, FB AF Berman, Nicola Dunham, Jonathan S. Baker, Joshua Vivino, Frederick B. TI Risk of Cervical Root and Incisal Caries in Patients with Sjogren's Syndrome. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Berman, Nicola] Penn Hosp, Philadelphia, PA 19107 USA. [Dunham, Jonathan S.] Univ Penn, Philadelphia, PA 19104 USA. [Baker, Joshua] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Vivino, Frederick B.] Penn Presbyt Med Ctr, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2545 BP S1112 EP S1113 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384905222 ER PT J AU Bethel, M Bailey, L Weaver, F Le, B Burns, S Svircev, J Heggeness, M Carbone, L AF Bethel, Monique Bailey, Lauren Weaver, Frances Le, Brian Burns, Stephen Svircev, Jelena Heggeness, Michael Carbone, Laura TI Surgical Compared with Nonsurgical Management of Fractures in Men with Chronic Spinal Cord Injury. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Bethel, Monique; Le, Brian] Georgia Regents Univ, Augusta, GA USA. [Bailey, Lauren; Weaver, Frances] Edward Hines Jr VA Hosp, Chicago, IL USA. [Burns, Stephen; Svircev, Jelena] VA Puget Sound Healthcare Syst, Seattle, WA USA. [Heggeness, Michael] Univ Kansas, Sch Med, Kansas City, KS USA. [Carbone, Laura] Charlie Norwood VA Med Ctr, Augusta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2106 BP S921 EP S921 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904255 ER PT J AU Bledsoe, C Davis, LA Tran, V Keniston, A Caplan, L Quinzanos, I Hirsh, JM AF Bledsoe, Carol Davis, Lisa A. Tran, Vivian Keniston, Angela Caplan, Liron Quinzanos, Itziar Hirsh, Joel M. TI Patients' Interpretations of Rheumatoid Arthritis Model Disease States in a Safety-Net Rheumatology Clinic SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Bledsoe, Carol] E Carolina Univ, Brody Sch Med, Greenville, NC USA. [Davis, Lisa A.] Denver VAMC, Aurora, CO USA. [Davis, Lisa A.; Caplan, Liron; Quinzanos, Itziar] Univ Colorado, Sch Med, Aurora, CO USA. [Tran, Vivian; Keniston, Angela; Hirsh, Joel M.] Denver Hlth & Hosp Author, Denver, CO USA. [Caplan, Liron] Denver VA, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2386 BP S1039 EP S1040 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384905064 ER PT J AU Castelino, FV George, LM Bain, G Goulet, L Lafyatis, R Tager, AM AF Castelino, Flavia V. George, Leaya M. Bain, Gretchen Goulet, Lance Lafyatis, Robert Tager, Andrew M. TI Autotaxin Is Highly Expressed in Systemic Sclerosis (SSc) Skin, Mediates Dermal Fibrosis Via IL-6, and Is a Target for SSc Therapy SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Castelino, Flavia V.; George, Leaya M.; Tager, Andrew M.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bain, Gretchen; Goulet, Lance] PharmAkea Pharmaceut, San Diego, CA USA. [Lafyatis, Robert] Boston Univ, Sch Med, Boston, MA 02118 USA. NR 1 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1796 BP S789 EP S789 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903419 ER PT J AU Chang, BH Quach, L Brophy, M Hannagan, K Keystone, EC Mikuls, TR O'Dell, JR AF Chang, Bei-Hung Lien Quach Brophy, Mary Hannagan, Keri Keystone, Edward C. Mikuls, Ted R. O'Dell, James R. TI Infections and Gastrointestinal Side Effects in a Comparison of Rheumatoid Arthritis Therapies SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Chang, Bei-Hung; Lien Quach; Brophy, Mary; Hannagan, Keri] VA Boston Healthcare Syst, Boston, MA USA. [Keystone, Edward C.] Univ Toronto, Toronto, ON, Canada. [Mikuls, Ted R.] Omaha VA Med Ctr, Omaha, NE USA. [Mikuls, Ted R.; O'Dell, James R.] Univ Nebraska Med Ctr, Omaha, NE USA. [O'Dell, James R.] Vet Affairs Nebraska Western Iowa Hlth Care Syst, Omaha, NE USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 462 BP S198 EP S198 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384901007 ER PT J AU Crowley, JT Drouin, EE Wang, Q McHugh, G Costello, CE Steere, AC AF Crowley, Jameson T. Drouin, Elise E. Wang, Qi McHugh, Gail Costello, Catherine E. Steere, Allen C. TI Apolipoprotein B Is a Target of T and B Cell Responses in a Subgroup of Patients with Lyme Disease SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Crowley, Jameson T.; Drouin, Elise E.; Steere, Allen C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Wang, Qi; Costello, Catherine E.] Boston Univ, Sch Med, Boston, MA 02118 USA. [McHugh, Gail] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 984 BP S438 EP S438 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902090 ER PT J AU Domsic, RT Nihtyanova, SI Lucas, M Wisniewski, SR Fine, MJ Kwoh, CK Denton, CP Medsger, TA AF Domsic, Robyn T. Nihtyanova, Svetlana I. Lucas, Mary Wisniewski, Stephen R. Fine, Michael J. Kwoh, C. Kent Denton, Christopher P. Medsger, Thomas A., Jr. TI Development and External Validation of a Five-Year Mortality Risk Stratification Tool for Early Diffuse Systemic Sclerosis Patients. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Domsic, Robyn T.; Lucas, Mary; Fine, Michael J.; Medsger, Thomas A., Jr.] Univ Pittsburgh, Pittsburgh, PA USA. [Nihtyanova, Svetlana I.] Royal Free & Univ Coll Med Sch, London WC1E 6BT, England. [Wisniewski, Stephen R.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA. [Fine, Michael J.] VA Pittsburgh Healthcare, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. [Kwoh, C. Kent] Univ Arizona, Arthrit Ctr, Tucson, AZ USA. [Denton, Christopher P.] Royal Free & Univ Coll Med Sch, Ctr Rheumatol, London WC1E 6BT, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2997 BP S1310 EP S1310 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384906231 ER PT J AU Dubreuil, M AF Dubreuil, Maureen TI Myocardial Infarction Risk with Diclofenac Use in Spondyloarthropathy Versus Non-Inflammatory Low Back Pain. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Dubreuil, Maureen] Boston VA HealthCare Syst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 554 BP S243 EP S243 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384901098 ER PT J AU Feldon, M Sikora, KA Harley, JB Huggins, JL Brunner, HI Kaufman, KM AF Feldon, Michal Sikora, Keith A. Harley, John B. Huggins, Jennifer L. Brunner, Hermine I. Kaufman, Kenneth M. TI Whole Exome Sequencing Analysis Performed on a Patient with Fibroblastic Rheumatism. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Feldon, Michal; Sikora, Keith A.; Huggins, Jennifer L.; Kaufman, Kenneth M.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Harley, John B.] Cincinnati Childrens Hosp Med Ctr, Med Ctr, US Dept Vet Affairs, Cincinnati, OH 45229 USA. [Brunner, Hermine I.] PRCSG, Cincinnati, OH USA. [Kaufman, Kenneth M.] Univ Cincinnati, Cincinnati, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 83 BP S35 EP S35 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384900084 ER PT J AU Fisher, MC Collier, DS AF Fisher, Mark C. Collier, Deborah S. TI Rheumatoid Arthritis Stable Follow up Visits-3 Month Versus 6 Month Intervals. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Fisher, Mark C.; Collier, Deborah S.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2425 BP S1058 EP S1058 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384905103 ER PT J AU Gauna, A Jin, JO Yu, Q Stewart, C Cha, S AF Gauna, Adrienne Jin, Jun-O Yu, Qing Stewart, Carol Cha, Seunghee TI MicroRNA-146a in Salivary Gland Epithelial Cells Inhibits Co-Stimulatory Molecule CD80 Expression and Increases Autoreactive T Cell Activation in Sjogren's Syndrome. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Gauna, Adrienne; Stewart, Carol; Cha, Seunghee] Univ Florida, Gainesville, FL USA. [Jin, Jun-O] Fudan Univ, Shanghai Med Coll, Shanghai 200433, Peoples R China. [Yu, Qing] Forsyth Inst, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2174 BP S949 EP S949 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904320 ER PT J AU Hamilton, J Li, J Wu, Q Yang, PA Luo, B Li, H Randall, T Bradley, JE Taylor, JJ Mountz, JD Hsu, HC AF Hamilton, Jennie Li, Jun Wu, Qi Yang, PingAr Luo, Bao Li, Hao Randall, Troy Bradley, John Edwin Taylor, Justin J. Mountz, John D. Hsu, Hui-Chen TI B-Cell Autoepitope and Tetramer Analysis Reveals Expansion of Apoptotic Autoantigen La and snRNP Reactive B Cells in BXD2 Mice. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Hamilton, Jennie; Li, Jun; Wu, Qi; Yang, PingAr; Luo, Bao; Li, Hao; Randall, Troy; Bradley, John Edwin; Hsu, Hui-Chen] Univ Alabama Birmingham, Birmingham, AL USA. [Taylor, Justin J.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Mountz, John D.] Birmingham VA Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2872 BP S1255 EP S1255 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384906107 ER PT J AU Hedrich, C Rauen, T Apostolidis, S Grammatikos, AP Rodriguez, NR Ioannidis, C Kyttaris, VC Crispin, JC Tsokos, GC AF Hedrich, Christian Rauen, Thomas Apostolidis, Sokratis Grammatikos, Alexandros P. Rodriguez, Noe Rodriguez Ioannidis, Christina Kyttaris, Vasileios C. Crispin, Jose C. Tsokos, George C. TI Stat3 Promotes IL-10 Expression in SLE T Cells through Transactivation and Chromatin Remodeling SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Hedrich, Christian] Childrens Hosp, Dresden, Germany. [Rauen, Thomas; Grammatikos, Alexandros P.; Rodriguez, Noe Rodriguez; Kyttaris, Vasileios C.; Crispin, Jose C.; Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. [Apostolidis, Sokratis; Ioannidis, Christina] BIDMC, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1033 BP S456 EP S457 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902138 ER PT J AU Hildebrand, B Higgs, JB Williamson, D Foa, E Resick, P Mintz, J Brundige, A Kelly, K Borah, A Young-McCaughan, S Litz, B Hembree, E Peterson, A AF Hildebrand, Bernard, Jr. Higgs, Jay B. Williamson, Douglas Foa, Edna Resick, Patricia Mintz, Jim Brundige, Antoinette Kelly, Kevin Borah, Adam Young-McCaughan, Stacey Litz, Brett Hembree, Elizabeth Peterson, Alan TI The Fibromyalgia Syndrome and Widespread Pain Frequency in Active Duty US Service Members with Posttraumatic Stress Disorder. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Hildebrand, Bernard, Jr.; Higgs, Jay B.] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA. [Williamson, Douglas; Mintz, Jim; Brundige, Antoinette; Young-McCaughan, Stacey; Peterson, Alan] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Foa, Edna; Hembree, Elizabeth] Univ Penn, Philadelphia, PA 19104 USA. [Resick, Patricia] Duke Univ, Durham, NC USA. [Kelly, Kevin; Borah, Adam] Carl R Darnall Army Med Ctr, Ft Hood, TX USA. [Litz, Brett] VA Boston Healthcare Syst, Boston, MA USA. RI Mintz, Jim/N-7385-2014 OI Mintz, Jim/0000-0002-8299-5851 NR 0 TC 1 Z9 1 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 895 BP S396 EP S396 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902002 ER PT J AU John, S Singhal, A Calabrese, LH Uchino, K Hammad, T Tepper, S Stillman, M Hajj-Ali, RA AF John, Seby Singhal, Aneesh Calabrese, Leonard H. Uchino, Ken Hammad, Tariq Tepper, Stewart Stillman, Mark Hajj-Ali, Rula A. TI Update on Long-Term Outcomes after Reversible Cerebral Vasoconstriction Syndrome (RCVS). SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [John, Seby; Calabrese, Leonard H.; Uchino, Ken; Hammad, Tariq; Tepper, Stewart; Stillman, Mark; Hajj-Ali, Rula A.] Cleveland Clin Fdn, Cleveland, OH 44195 USA. [Singhal, Aneesh] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2856 BP S1248 EP S1248 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384906091 ER PT J AU Kohler, MJ Slocum, C Siddiqui, I O'Connor, K Bolster, MB AF Kohler, Minna J. Slocum, Chloe Siddiqui, Imran O'Connor, Kevin Bolster, Marcy B. TI Implementation of a Collaborative Rheumatology and Physiatry Musculoskeletal Ultrasound Training Program. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Kohler, Minna J.; Bolster, Marcy B.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Slocum, Chloe; Siddiqui, Imran; O'Connor, Kevin] Harvard Univ, Sch Med, Spaulding Rehabil Hosp, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2002 BP S879 EP S880 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904152 ER PT J AU Le, B Bethel, M Bailey, L Weaver, F Burns, S Svircev, J Heggeness, M Carbone, L AF Le, Brian Bethel, Monique Bailey, Lauren Weaver, Frances Burns, Stephen Svircev, Jelena Heggeness, Michael Carbone, Laura TI Nonsurgical Treatment Patterns in Patients with Chronic Spinal Cord Injury. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Le, Brian; Bethel, Monique] Georgia Regents Univ, Augusta, GA USA. [Bailey, Lauren; Weaver, Frances] Edward Hines Jr VA Hosp, Chicago, IL USA. [Burns, Stephen; Svircev, Jelena] VA Puget Sound Healthcare Syst, Seattle, WA USA. [Heggeness, Michael] Univ Kansas, Sch Med, Kansas City, KS USA. [Carbone, Laura] Charlie Norwood VA Med Ctr, Augusta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2105 BP S921 EP S921 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904254 ER PT J AU Leatherman, S Wu, HS Keystone, E Brophy, M O'Dell, J AF Leatherman, Sarah Wu, Hongsheng Keystone, Edward Brophy, Mary O'Dell, James TI Compliance in the Rheumatoid Arthritis Comparison of Active Therapies Trial: Triple Vs Etanercept SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Leatherman, Sarah; Brophy, Mary] VA Boston Healthcare Syst, Boston, MA USA. [Wu, Hongsheng] Wentworth Inst Technol, Boston, MA USA. [Keystone, Edward] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada. [O'Dell, James] Univ Nebraska Med Ctr, Omaha, NE USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2373 BP S1033 EP S1033 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384905051 ER PT J AU Lee, YC Massarotti, E Edwards, RR Lu, B Liu, CC Lo, YY Wohlfahrt, A Kim, N Clauw, DJ Solomon, DH AF Lee, Yvonne C. Massarotti, Elena Edwards, Robert R. Lu, Bing Liu, Chih-Chin Lo, Yuanyu Wohlfahrt, Alyssa Kim, Nancy Clauw, Daniel J. Solomon, Daniel H. TI The Effect of Milnacipran on Pain in Rheumatoid Arthritis Patients with Widespread Pain: a Randomized Blinded Crossover Trial. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Lee, Yvonne C.; Massarotti, Elena; Lu, Bing; Liu, Chih-Chin; Lo, Yuanyu; Wohlfahrt, Alyssa; Solomon, Daniel H.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Edwards, Robert R.] Brigham & Womens Hosp, Chestnut Hill, MA USA. [Kim, Nancy] Massachusetts Gen Hosp, Charlestown, MA USA. [Clauw, Daniel J.] Univ Michigan, Ann Arbor, MI 48109 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 254 BP S106 EP S106 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384900254 ER PT J AU Lew, R Rybin, D Hannagan, K Wu, HS Keystone, E Mikuls, TR O' Dell, J AF Lew, Robert Rybin, Denis Hannagan, Keri Wu, Hongsheng Keystone, Edward Mikuls, Ted R. O' Dell, James TI Follow-up Data on the Rheumatoid Arthritis Comparison of Active Therapies Trial: Observational Cohort. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Lew, Robert; Hannagan, Keri] VA Boston Heathcare Syst, Boston, MA USA. [Rybin, Denis] VA Boston Healthcare Syst, Boston, MA USA. [Wu, Hongsheng] Wentworth Inst Technol, Boston, MA USA. [Keystone, Edward] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada. [Mikuls, Ted R.; O' Dell, James] Omaha VA Med Ctr, Omaha, NE USA. [Mikuls, Ted R.; O' Dell, James] Univ Nebraska Med Ctr, Omaha, NE USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1523 BP S670 EP S671 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903147 ER PT J AU Miloslavsky, EM Bolster, MB O'Rourke, KS Criscione-Schreiber, LG AF Miloslavsky, Eli M. Bolster, Marcy B. O'Rourke, Kenneth S. Criscione-Schreiber, Lisa G. TI Assessing Rheumatology Fellows' Teaching Skills Using the Objective Structured Teaching Exercise (OSTE). SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Miloslavsky, Eli M.; Bolster, Marcy B.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [O'Rourke, Kenneth S.] Wake Forest Sch Med, Winston Salem, NC USA. [Criscione-Schreiber, Lisa G.] Duke Univ Hlth Syst, Durham, NC USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2886 BP S1261 EP S1261 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384906121 ER PT J AU Miyabe, Y Murooka, TT Miyabe, C Kim, N Mempel, TR Lusrter, AD AF Miyabe, Yoshishige Murooka, Thomas T. Miyabe, Chie Kim, Nancy Mempel, Thorsten R. Lusrter, Andrew D. TI Imaging the Role of Chemoattractants in Inflammatory Arthritis SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Miyabe, Yoshishige; Murooka, Thomas T.; Miyabe, Chie; Kim, Nancy; Mempel, Thorsten R.; Lusrter, Andrew D.] Massachusetts Gen Hosp, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1041 BP S460 EP S460 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902146 ER PT J AU Mlakar, L Takihara, T Sprachman, M Wipf, P Feghali-Bostwick, C AF Mlakar, Logan Takihara, Takahisa Sprachman, Melissa Wipf, Peter Feghali-Bostwick, Carol TI Anti-Fibrotic Effects of an Investigational Drug: Bis-Oxetanyl Sulfoxide. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Mlakar, Logan; Feghali-Bostwick, Carol] Med Univ S Carolina, Charleston, SC 29425 USA. [Takihara, Takahisa] Tokai Univ, Sch Med, Kanagawa 2591100, Japan. [Sprachman, Melissa] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Wipf, Peter] Univ Pittsburgh, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 769 BP S337 EP S337 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384901313 ER PT J AU Munroe, ME Young, KA Fessler, J Fife, D Kamen, DL Guthridge, JM Niewold, TB Weisman, MH Ishimori, ML Wallace, DJ Karp, DR Harley, JB Gilkeson, GS Norris, JM James, JA AF Munroe, Melissa E. Young, Kendra A. Fessler, Jennifer Fife, Dustin Kamen, Diane L. Guthridge, Joel M. Niewold, Timothy B. Weisman, Michael H. Ishimori, Mariko L. Wallace, Daniel J. Karp, David R. Harley, John B. Gilkeson, Gary S. Norris, Jill M. James, Judith A. TI Elevated Levels of Soluble Inflammatory Mediators and Lupus-Specific Connective Tissue Disease Questionnaire Scores Discern Unaffected First Degree Relatives of Lupus Patients from Unaffected Individuals Not Related to Lupus Patients. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Munroe, Melissa E.; Fessler, Jennifer; Fife, Dustin; Guthridge, Joel M.; James, Judith A.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [Young, Kendra A.; Norris, Jill M.] Colorado Sch Publ Hlth, Aurora, CO USA. [Kamen, Diane L.; Gilkeson, Gary S.] Med Univ S Carolina, Charleston, SC 29425 USA. [Niewold, Timothy B.] Mayo Clin, Rochester, MN USA. [Weisman, Michael H.; Ishimori, Mariko L.; Wallace, Daniel J.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Karp, David R.] UT Southwestern Med Ctr, Dallas, TX USA. [Harley, John B.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Harley, John B.] US Dept Vet Affairs, Med Ctr, Cincinnati, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2880 BP S1258 EP S1258 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384906115 ER PT J AU Myung, G Harada, ND Fong, SL Aquino-Beaton, C Fang, MA AF Myung, Gihyun Harada, Nancy D. Fong, Stephanie L. Aquino-Beaton, Cleopatra Fang, Meika A. TI Characterization of Social Stigma in Rheumatic Diseases and Correlation with Quality of Life and Medication Adherence. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Myung, Gihyun] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Harada, Nancy D.] Univ Calif Los Angeles, David Geffen Sch Med, Long Beach, CA USA. [Fong, Stephanie L.; Fang, Meika A.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Aquino-Beaton, Cleopatra] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2107 BP S921 EP S922 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904256 ER PT J AU Ogdie, A Angeles-Han, S Makris, U Nelson, A Shah, A Jiang, YH Kahlenberg, JM Muscal, E Castelino, FV Golding, A Kim, A AF Ogdie, Alexis Angeles-Han, Sheila Makris, Una Nelson, Amanda Shah, Ami Jiang, Yihui Kahlenberg, J. Michelle Muscal, Eyal Castelino, Flavia V. Golding, Amit Kim, Alfred TI Barriers and Facilitators of a Career in Research Among Rheumatologists in the United States. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Ogdie, Alexis; Jiang, Yihui] Univ Penn, Philadelphia, PA 19104 USA. [Angeles-Han, Sheila] Emory Univ, Sch Med, Atlanta, GA USA. [Makris, Una] Dallas VA Med Ctr, Dallas, TX USA. [Nelson, Amanda] Univ N Carolina, Chapel Hill, NC USA. [Shah, Ami] Johns Hopkins Univ, Baltimore, MD USA. [Kahlenberg, J. Michelle] Univ Michigan, Ann Arbor, MI 48109 USA. [Muscal, Eyal] Texas Childrens Hosp, Houston, TX 77030 USA. [Castelino, Flavia V.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Golding, Amit] Baltimore VA, Baltimore, MD USA. [Golding, Amit] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Kim, Alfred] Washington Univ, Sch Med, St Louis, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1151 BP S505 EP S506 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902256 ER PT J AU Ogdie, A Shah, A Makris, U Kim, A Angeles-Han, S Golding, A Kahlenberg, JM Muscal, E Castelino, FV Nelson, A AF Ogdie, Alexis Shah, Ami Makris, Una Kim, Alfred Angeles-Han, Sheila Golding, Amit Kahlenberg, J. Michelle Muscal, Eyal Castelino, Flavia V. Nelson, Amanda TI Reasons for Leaving an Academic Career in Research Among Rheumatologists in the United States. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Ogdie, Alexis] Univ Penn, Philadelphia, PA 19104 USA. [Shah, Ami] Johns Hopkins Univ, Baltimore, MD USA. [Makris, Una] Dallas VA Med Ctr, Dallas, TX USA. [Kim, Alfred] Washington Univ, Sch Med, St Louis, MO USA. [Angeles-Han, Sheila] Emory Univ, Sch Med, Atlanta, GA USA. [Golding, Amit] Baltimore VA, Baltimore, MD USA. [Golding, Amit] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Kahlenberg, J. Michelle] Univ Michigan, Ann Arbor, MI 48109 USA. [Muscal, Eyal] Texas Childrens Hosp, Houston, TX 77030 USA. [Castelino, Flavia V.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Nelson, Amanda] Univ N Carolina, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 104 BP S44 EP S45 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384900105 ER PT J AU Patel, R Mikuls, TR Richards, JS Cannon, GW Kerr, GS Davis, LA Caplan, L Baker, JF AF Patel, Ruchika Mikuls, Ted R. Richards, J. Steuart Cannon, Grant W. Kerr, Gail S. Davis, Lisa A. Caplan, Liron Baker, Joshua F. TI Prevalence of Cardiovascular Disease in US Veterans with Rheumatoid Arthritis and Hepatitis C Infection. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Patel, Ruchika; Baker, Joshua F.] Univ Penn, Philadelphia, PA 19104 USA. [Patel, Ruchika] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Mikuls, Ted R.] Omaha VA Med Ctr, Omaha, NE USA. [Mikuls, Ted R.] Univ Nebraska Med Ctr, Omaha, NE USA. [Richards, J. Steuart] Washington DC VA, Washington, DC USA. [Richards, J. Steuart] Georgetown Univ, Washington, DC USA. [Cannon, Grant W.] Salt Lake City VA, Salt Lake City, UT USA. [Cannon, Grant W.] Univ Utah, Salt Lake City, UT USA. [Kerr, Gail S.] Washington DC VAMC, Georgetown, DC USA. [Kerr, Gail S.] Howard Univ, Washington, DC 20059 USA. [Davis, Lisa A.] Denver VAMC, Aurora, CO USA. [Davis, Lisa A.; Caplan, Liron] Univ Colorado, Sch Med, Aurora, CO USA. [Caplan, Liron] Denver VA, Aurora, CO USA. [Baker, Joshua F.] Philadelphia VAMC, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1372 BP S604 EP S605 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902476 ER PT J AU Pianta, A Drouin, EE Arvikar, S Costello, CE Steere, AC AF Pianta, Annalisa Drouin, Elise E. Arvikar, Sheila Costello, Catherine E. Steere, Allen C. TI Identification of Annexin A2 As an Autoantigen in Rheumatoid Arthritis and in Lyme Arthritis SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Pianta, Annalisa; Drouin, Elise E.; Steere, Allen C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Arvikar, Sheila] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Costello, Catherine E.] Boston Univ, Sch Med, Boston, MA 02118 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 983 BP S437 EP S438 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902089 ER PT J AU Quinzanos, I Luong, P Bobba, S Richards, JS Majithia, V Davis, LA Caplan, L AF Quinzanos, Itziar Luong, Phat Bobba, Sushmitha Richards, J. Steuart Majithia, Vikas Davis, Lisa A. Caplan, Liron TI Validation of Modified Disease Activity and Functional Status Questionnaires in Spondyloarthritis. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Quinzanos, Itziar; Luong, Phat] Denver VA Med Ctr, Denver, CO USA. [Bobba, Sushmitha] Dept Vet Affairs, Denver, CO USA. [Richards, J. Steuart] Washington DC VA, Washington, DC USA. [Richards, J. Steuart] Georgetown Univ, Washington, DC USA. [Majithia, Vikas] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA. [Davis, Lisa A.] Denver VAMC, Aurora, CO USA. [Davis, Lisa A.; Caplan, Liron] Univ Colorado, Sch Med, Aurora, CO USA. [Caplan, Liron] Denver VA, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2570 BP S1123 EP S1124 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384905247 ER PT J AU Robinson, ES Okawa, J Feng, R Payne, AS Werth, VP AF Robinson, Elizabeth S. Okawa, Joyce Feng, Rui Payne, Aimee S. Werth, Victoria P. TI The Incidence of Zoster in Patients with Cutaneous Lupus Erythematosus and Dermatomyositis Is Increased Compared to the Average US Population. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Robinson, Elizabeth S.; Werth, Victoria P.] Vet Affairs Med Ctr, Philadelphia, PA USA. [Okawa, Joyce; Feng, Rui; Payne, Aimee S.] Univ Penn, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2206 BP S961 EP S961 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904352 ER PT J AU Schoenfeld, S Miloslavsky, E Yang, WH Rastalsky, N Carruthers, M Wallace, Z Powers, T Bolster, M Collier, D AF Schoenfeld, Sara Miloslavsky, Eli Yang, Weihong Rastalsky, Naina Carruthers, Mollie Wallace, Zachary Powers, Traci Bolster, Marcy Collier, Deborah TI A Decision Support Tool to Improve Herpes Zoster Vaccination Rates Among Patients Starting Biologic Medications. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Schoenfeld, Sara; Miloslavsky, Eli; Yang, Weihong; Rastalsky, Naina; Carruthers, Mollie; Wallace, Zachary; Powers, Traci; Collier, Deborah] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bolster, Marcy] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1349 BP S593 EP S593 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384902453 ER PT J AU Scofield, RH Igoe, A Stone, DU Radfar, L Hefner, KS Lewis, DM Young, S Harris, J Grundahl, K Kurien, BT Maier-Moore, J Koelsch, KA Chodosh, J Rhodus, NL Gopalakrishnan, R Segal, BM Farris, AD Montgomery, CG Lessard, CJ Sivils, KL Rasmussen, A AF Scofield, R. Hal Igoe, Anne Stone, Donald U. Radfar, Lida Hefner, Kimberly S. Lewis, David M. Young, Stephen Harris, Judy Grundahl, Kiely Kurien, Biji T. Maier-Moore, Jacen Koelsch, Kristi A. Chodosh, James Rhodus, Nelson L. Gopalakrishnan, Raj Segal, Barbara M. Farris, A. Darise Montgomery, Courtney G. Lessard, Christopher J. Sivils, Kathy L. Rasmussen, Astrid TI Anti-Ro/SSA Positive Incomplete Sjogren's Syndrome. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Scofield, R. Hal; Kurien, Biji T.] US Dept Vet Affairs Med Ctr, Oklahoma City, OK USA. [Igoe, Anne] Metro Hlth, Cleveland, OH USA. [Stone, Donald U.] Dean McGee Eye Inst, Oklahoma City, OK USA. [Radfar, Lida; Lewis, David M.; Young, Stephen; Sivils, Kathy L.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Hefner, Kimberly S.] Hefner Eye Care & Opt Ctr, Oklahoma City, OK USA. [Harris, Judy; Grundahl, Kiely; Farris, A. Darise; Montgomery, Courtney G.; Lessard, Christopher J.; Rasmussen, Astrid] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [Maier-Moore, Jacen] Univ Texas El Paso, El Paso, TX 79968 USA. [Koelsch, Kristi A.] Oklahoma Med Res Fdn, Okalahoma City, OK USA. [Chodosh, James] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Boston, MA USA. [Rhodus, Nelson L.; Gopalakrishnan, Raj] Univ Minnesota, Minneapolis, MN USA. [Segal, Barbara M.] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2543 BP S1111 EP S1112 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384905220 ER PT J AU Rodriguez-Reyna, TS Zuniga, J Granados, J Velazquez, PM Alvarez, CN Yu, N Alosco, S Lagunas, AC Yunis, E AF Sofia Rodriguez-Reyna, Tatiana Zuniga, Joaquin Granados, Julio Mercado Velazquez, Pamela Nunez Alvarez, Carlos Yu, Neng Alosco, Sharon Cruz Lagunas, Alfredo Yunis, Edmond TI MHC Class I and Class II Genes Influence Systemic Sclerosis Susceptibility, Clinical Presentation and Autoantibody Profile in a Mexican Admixed Population. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Sofia Rodriguez-Reyna, Tatiana; Mercado Velazquez, Pamela; Nunez Alvarez, Carlos] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico. [Zuniga, Joaquin] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico. [Granados, Julio] Inst Nacl Ciencias Med & Nutr Salvador Zubira, Mexico City, DF, Mexico. [Yu, Neng; Alosco, Sharon] Amer Red Cross Blood Serv, Northeast Div, Dedham, MA USA. [Cruz Lagunas, Alfredo] Inst Nacl Enfermedades Resp, Mexico City, DF, Mexico. [Yunis, Edmond] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1716 BP S755 EP S756 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903340 ER PT J AU Solow, EB Yu, F Thiele, GM Sokolove, J Robinson, WH Pruhs, ZM Michaud, K Erickson, AR Sayles, H Kerr, GS Gaffo, AL Caplan, L Davis, LA Cannon, GW Reimold, AM Baker, J Schwab, P Anderson, D Mikuls, TR AF Solow, E. Blair Yu, Fang Thiele, Geoffrey M. Sokolove, Jeremy Robinson, William H. Pruhs, Zachary M. Michaud, Kaleb Erickson, Alan R. Sayles, Harlan Kerr, Gail S. Gaffo, Angelo L. Caplan, Liron Davis, Lisa A. Cannon, Grant W. Reimold, Andreas M. Baker, Joshua Schwab, Pascale Anderson, Daniel Mikuls, Ted R. TI Vascular Calcifications on Hand and Wrist Radiographs Are Associated with Cardiovascular Risk Factors, Antigen-Specific Anti-Citrullinated Protein Antibodies, and Mortality in Rheumatoid Arthritis. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Solow, E. Blair] UT Southwestern Med Ctr, Dallas, TX USA. [Yu, Fang; Thiele, Geoffrey M.; Pruhs, Zachary M.; Michaud, Kaleb; Erickson, Alan R.; Sayles, Harlan; Anderson, Daniel; Mikuls, Ted R.] Univ Nebraska Med Ctr, Omaha, NE USA. [Thiele, Geoffrey M.; Pruhs, Zachary M.; Michaud, Kaleb; Erickson, Alan R.; Sayles, Harlan; Anderson, Daniel; Mikuls, Ted R.] Omaha VA Med Ctr, Omaha, NE USA. [Sokolove, Jeremy] VA Palo Alto Healthcare Syst, Palo Alto, CA USA. [Sokolove, Jeremy; Robinson, William H.] Stanford Univ, Palo Alto, CA 94304 USA. [Robinson, William H.] VA Palo Alto Hlth Care Syst, Palo Alto, CA USA. [Kerr, Gail S.] Georgetown & Howard Univ, Washington DC VAMC, Washington, DC USA. [Gaffo, Angelo L.] Birmingham VA Med Ctr, Birmingham, AL USA. [Gaffo, Angelo L.] Univ Alabama Birmingham, Birmingham, AL USA. [Caplan, Liron; Davis, Lisa A.] Denver VAMC, Aurora, CO USA. [Caplan, Liron; Davis, Lisa A.] Univ Colorado, Sch Med, Aurora, CO USA. [Cannon, Grant W.] Salt Lake City VA, Salt Lake City, UT USA. [Cannon, Grant W.] Univ Utah, Salt Lake City, UT USA. [Reimold, Andreas M.] Dallas VA, Dallas, TX USA. [Reimold, Andreas M.] Univ Texas Southwestern, Dallas, TX USA. [Baker, Joshua] Univ Penn, Philadelphia, PA 19104 USA. [Baker, Joshua] Philadelphia VAMC, Philadelphia, PA 19104 USA. [Schwab, Pascale] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 840 BP S370 EP S371 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384901384 ER PT J AU Strle, K Drouin, EE Steere, AC AF Strle, Klemen Drouin, Elise E. Steere, Allen C. TI T(H)17 Inflammatory Responses Occur in a Subset of Patients with Erythema Migrans or Lyme Arthritis, but Are Not Predominant Responses in Joints SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Strle, Klemen; Drouin, Elise E.; Steere, Allen C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1970 BP S866 EP S866 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384904120 ER PT J AU Sullivan, B Guzman, R Russell, CB Arnold, G Boedigheimer, M Ma, C Chung, J Werth, VP Martin, DA AF Sullivan, Barbara Guzman, Roberto Russell, Christopher B. Arnold, Greg Boedigheimer, Michael Ma, Connie Chung, James Werth, Victoria P. Martin, David A. TI Molecular, Cellular and Histopathologic Assessment of Baseline Characteristics of Sixteen Subjects with Discoid Lupus Erythematosus Prior to Treatment with AMG 811 (anti-IFN gamma). SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Sullivan, Barbara; Guzman, Roberto; Arnold, Greg; Boedigheimer, Michael; Ma, Connie; Chung, James] Amgen Inc, Thousand Oaks, CA USA. [Russell, Christopher B.; Martin, David A.] Amgen Inc, Seattle, WA USA. [Werth, Victoria P.] Vet Affairs Med Ctr, Philadelphia, PA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1646 BP S725 EP S726 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903270 ER PT J AU Thiyagarajan, T Molano, I Nowling, TK AF Thiyagarajan, Thirumagal Molano, Ivan Nowling, Tamara K. TI The Role of Fli1 in Lupus T Cell Function and Nephritis. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Thiyagarajan, Thirumagal; Molano, Ivan; Nowling, Tamara K.] Med Univ S Carolina, Charleston, SC 29425 USA. [Nowling, Tamara K.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2741 BP S1198 EP S1199 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384905418 ER PT J AU Thiyagarajan, T Siskind, L Oates, J Drake, R Nowling, TK AF Thiyagarajan, Thirumagal Siskind, Leah Oates, Jim Drake, Richard Nowling, Tamara K. TI Dysfunction of Glycosphingolipid Metabolism in Lupus Nephritis SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Thiyagarajan, Thirumagal; Oates, Jim; Drake, Richard; Nowling, Tamara K.] Med Univ S Carolina, Charleston, SC 29425 USA. [Siskind, Leah] Univ Louisville, Louisville, KY 40292 USA. [Nowling, Tamara K.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 661 BP S288 EP S289 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384901205 ER PT J AU Unizony, S Miloslavsky, EM Villarreal, M Merkel, PA Monach, P St Claire, EW Kallenberg, C Ikle, D Spiera, RF Tchao, N Phippard, DJ Ding, L Langford, CA Seo, P Hoffman, GS Stone, JH Specks, U AF Unizony, Sebastian Miloslavsky, Eli M. Villarreal, Miguel Merkel, Peter A. Monach, Paul St Claire, E. William Kallenberg, Cees Ikle, David Spiera, Robert F. Tchao, Nadia Phippard, Deborah J. Ding, Linna Langford, Carol A. Seo, Philip Hoffman, Gary S. Stone, John H. Specks, Ulrich TI Comparison of Clinicopathologically- and Serologically-Based Classification Systems for ANCA-Associated Vasculitis SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Unizony, Sebastian; Miloslavsky, Eli M.; Stone, John H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Villarreal, Miguel; Ikle, David] Rho, Chapel Hill, NC USA. [Merkel, Peter A.] Univ Penn, Vasculitis Ctr, Philadelphia, PA 19104 USA. [Monach, Paul] Boston Univ, Boston, MA 02215 USA. [St Claire, E. William] Duke Univ Sch Med, Durham, NC USA. [Kallenberg, Cees] Univ Groningen, Groningen, Netherlands. [Spiera, Robert F.] Hosp Special Surg, New York, NY 10021 USA. [Tchao, Nadia; Phippard, Deborah J.] Immune Tolerance Network, Bethesda, MD USA. [Ding, Linna] NIAID, Bethesda, MD 20892 USA. [Langford, Carol A.] Cleveland Clin, Ctr Vasculitis Care & Res, Cleveland, OH 44106 USA. [Seo, Philip] Johns Hopkins Univ, Johns Hopkins Vasculitis Ctr, Baltimore, MD USA. [Hoffman, Gary S.] Cleveland Clin Fdn, Ctr Vasculitis Care & Res, Cleveland, OH 44195 USA. [Specks, Ulrich] Mayo Clin, Rochester, MN USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1766 BP S775 EP S776 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903389 ER PT J AU Unizony, S Lim, N Carey, V Phippard, DJ Tchao, N Miloslavsky, EM Merkel, PA Monach, P St Clair, W Spiera, RF Asare, A Seo, P Langford, CA Hoffman, GS Kallenberg, C Specks, U Stone, JH AF Unizony, Sebastian Lim, Noha Carey, Vincent Phippard, Deborah J. Tchao, Nadia Miloslavsky, Eli M. Merkel, Peter A. Monach, Paul St Clair, William Spiera, Robert F. Asare, Adam Seo, Philip Langford, Carol A. Hoffman, Gary S. Kallenberg, Cees Specks, Ulrich Stone, John H. TI Peripheral CD5(+) b-Cells in ANCA-Associated Vasculitis SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Unizony, Sebastian; Miloslavsky, Eli M.; Stone, John H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Lim, Noha; Phippard, Deborah J.; Tchao, Nadia; Asare, Adam] Immune Tolerance Network, Bethesda, MD USA. [Carey, Vincent] Brigham & Womens Hosp, Boston, MA 02115 USA. [Merkel, Peter A.] Univ Penn, Vasculitis Ctr, Div Rheumatol, Philadelphia, PA 19104 USA. [Monach, Paul] Boston Univ, Boston, MA 02215 USA. [St Clair, William] Duke Univ, Durham, NC USA. [Spiera, Robert F.] Hosp Special Surg, New York, NY 10021 USA. [Seo, Philip] Johns Hopkins Univ, Johns Hopkins Vasculitis Ctr, Baltimore, MD USA. [Langford, Carol A.] Cleveland Clin, Ctr Vasculitis Care & Res, Cleveland, OH 44106 USA. [Hoffman, Gary S.] Cleveland Clin Fdn, Cleveland, OH 44195 USA. [Kallenberg, Cees] Univ Groningen, Groningen, Netherlands. [Specks, Ulrich] Mayo Clin, Rochester, MN USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 1754 BP S769 EP S770 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384903377 ER PT J AU Unizony, S Menendez, M Rastalsky, N Stone, JH AF Unizony, Sebastian Menendez, Mariano Rastalsky, Naina Stone, John H. TI Inpatient Complications in Patients with Giant Cell Arteritis: Increased Risk of Thromboembolism, Delirium and Adrenal Insufficiency. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Unizony, Sebastian; Menendez, Mariano; Rastalsky, Naina; Stone, John H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 802 BP S351 EP S351 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384901346 ER PT J AU Wallace, Z Deshpande, V Mattoo, H Mahajan, V Carruthers, M Kulikova, M Pillai, S Stone, JH AF Wallace, Zachary Deshpande, Vikram Mattoo, Hamid Mahajan, Vinay Carruthers, Mollie Kulikova, Maria Pillai, Shiv Stone, John H. TI IgG4-Related Disease: Baseline Features in 100 Patients with Biopsy-Proven Disease SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Wallace, Zachary; Deshpande, Vikram; Carruthers, Mollie; Kulikova, Maria; Pillai, Shiv; Stone, John H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Mattoo, Hamid; Mahajan, Vinay] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2805 BP S1224 EP S1225 PG 2 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384906041 ER PT J AU Wallace, Z Carruthers, M Stone, JH AF Wallace, Zachary Carruthers, Mollie Stone, John H. TI Rituximab in IgG4-Related Disease: A Large Single-Center Experience SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Wallace, Zachary; Carruthers, Mollie; Stone, John H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 2804 BP S1224 EP S1224 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384906040 ER PT J AU Everett, CJ AF Everett, Charles J. TI Commentary on nephropathy and longitudinal studies of diabetes, and dioxins, furans, and dioxin-like PCBs SO ENVIRONMENTAL RESEARCH LA English DT Editorial Material C1 US Dept Vet Affairs, Ralph H Johnson VA Med Ctr, Charleston, SC 29401 USA. RP Everett, CJ (reprint author), US Dept Vet Affairs, Ralph H Johnson VA Med Ctr, 109 Bee St,Mail Code 151, Charleston, SC 29401 USA. EM Charles.Everett@va.gov NR 1 TC 0 Z9 2 U1 1 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD OCT PY 2014 VL 134 SI SI BP 8 EP 8 DI 10.1016/j.envres.2014.06.020 PG 1 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AX3CB UT WOS:000346817100002 PM 25042030 ER PT J AU Seano, G Daubon, T Genot, E Primo, L AF Seano, Giorgio Daubon, Thomas Genot, Elisabeth Primo, Luca TI Podosomes as novel players in endothelial biology SO EUROPEAN JOURNAL OF CELL BIOLOGY LA English DT Review DE Podosome; Endothelial cell; Tumour angiogenesis; Invadosome; Rosette; Vascular sprouting ID VIRUS-TRANSFORMED FIBROBLASTS; WISKOTT-ALDRICH-SYNDROME; EXTRACELLULAR-MATRIX; CYTOSKELETON ORGANIZATION; ROSETTE FORMATION; SEALING ZONE; CELLS; MEMBRANE; PROTEIN; ANGIOGENESIS AB Podosomes and invadopodia, collectively known as invadosomes, are specialized cell matrix contacts with an inherent ability to degrade extracellular matrix. Their occurrence in either normal (podosomes) or cancer cells (invadopodia) is thus traditionally associated with cell invasiveness and tissue remodelling. These specialized micro-domains of the plasma membrane are characterized by enrichment of F-actin, cortactin and metalloproteases. Recent developments in the field show that, under some circumstances, vascular endothelial cells (ECs) can be induced to form this kind of peculiar structures. Cultured ECs contain either 0.5-1-mu m-wide individual podosomes or 5 to 10 mu m wide ring-like clusters of podosomes (podosome rosettes). The formation of individual podosomes or podosome rosettes in ECs can be induced by soluble factors, such as TGF beta, VEGF, TNF alpha or pharmacological agents, such as phorbol esters. Recently, the evidence of the existence of such structures in vascular endothelium has been provided by ex vivo observation. Endothelial podosome rosettes have recently been functionally linked to arterial remodelling and sprouting angiogenesis. Concerted efforts aim now at confirming the relevance of endothelial podosomes in these patho-physiological processes in vivo. In the current review, we will introduce some general considerations regarding ECs in the vascular system. From there on, we will review the various EC types where podosomes have been described and the state-of-art knowledge hitherto generated regarding endothelial podosome features. (C) 2014 Elsevier GmbH. All rights reserved. C1 [Seano, Giorgio; Primo, Luca] IRCCS, FPO, Candiolo Canc Inst, Lab Cell Migrat, Turin, Italy. [Seano, Giorgio] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Edwin L Steele Lab Tumor Biol,Dept Radiat Oncol, Boston, MA USA. [Daubon, Thomas; Genot, Elisabeth] Univ Bordeaux, European Inst Chem & Biol, Pessac, France. [Daubon, Thomas; Genot, Elisabeth] Univ Bordeaux, INSERM, Bordeaux, France. [Primo, Luca] Univ Turin, Dept Oncol, Turin, Italy. RP Primo, L (reprint author), Candiolo Canc Inst FPO, Str Prov 142, I-10060 Candiolo, Italy. EM e.genot@iecb.u-bordeaux.fr; luca.primo@ircc.it RI GENOT, Elisabeth/G-6427-2015; GENOT, Elisabeth/G-8031-2014; OI GENOT, Elisabeth/0000-0002-5212-5994; Seano, Giorgio/0000-0002-7294-302X FU Associazione Italiana per la Ricerca sul Cancro [IG 14635]; MIUR-Fondo Investimenti per la Ricerca di Base [RBAP11BYNP Newton]; European Union [237946]; French National Research Agency [ANR 2010 BLAN 123701]; French Cancer Research Association (ARC) [5040]; French Ligue contre le Cancer ("Comite du Lot et Garonne") FX This work was supported by: Associazione Italiana per la Ricerca sul Cancro (IG 14635) and MIUR-Fondo Investimenti per la Ricerca di Base (RBAP11BYNP Newton) to LP; and by European Union Seventh Framework Programme (grant number 237946), French National Research Agency (grant number ANR 2010 BLAN 123701.), French Cancer Research Association (grant number ARC no. 5040) and French Ligue contre le Cancer ("Comite du Lot et Garonne") to EG. NR 47 TC 0 Z9 0 U1 1 U2 8 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 0171-9335 EI 1618-1298 J9 EUR J CELL BIOL JI Eur. J. Cell Biol. PD OCT PY 2014 VL 93 IS 10-12 BP 405 EP 412 PG 8 WC Cell Biology SC Cell Biology GA AY0FA UT WOS:000347271800005 PM 25199436 ER PT J AU Mavandadi, S Dobkin, R Mamikonyan, E Sayers, S Ten Have, T Weintraub, D AF Mavandadi, Shahrzad Dobkin, Roseanne Mamikonyan, Eugenia Sayers, Steven Ten Have, Thomas Weintraub, Daniel TI Benefit Finding and Relationship Quality in Parkinson's Disease: A Pilot Dyadic Analysis of Husbands and Wives SO JOURNAL OF FAMILY PSYCHOLOGY LA English DT Article DE chronic disease; Parkinson's disease; marital relationship; psychosocial support systems caregiving ID STAGE BREAST-CANCER; MARITAL QUALITY; POSTTRAUMATIC GROWTH; CAREGIVER-BURDEN; SOCIAL SUPPORT; YOUNG-ONSET; SATISFACTION; HEALTH; DEPRESSION; EXPERIENCE AB Parkinson's disease (PD) significantly impacts both patients' and spouses' emotional and physical health. However, despite the importance of social relationships for wellbeing, few studies have examined relationship quality and their correlates in individuals with PD and their partners. Specifically, no known studies have examined the association between benefit finding, or the experience of personal growth and other positive changes in the face of a stressor, and perceived marital quality. To address these gaps in the field, 25 married couples participated in a cross-sectional, pilot study. Patients were veterans diagnosed with idiopathic PD receiving care at the Philadelphia VA Medical Center. Each patient and spouse independently completed self-reported measures of sociodemographics, physical and mental wellbeing, caregiver burden, marital quality, and perceived benefits associated with having PD. Actor-partner interdependence models revealed that, after adjusting for covariates, greater perceived benefits from either having PD or living with a spouse with PD was associated with greater marital quality, both for that individual and their partner. Thus, perceiving positive consequences, such as personal growth, as a result of personally having PD or living with a spouse with PD is related to greater marital quality for both members of the marital dyad. Findings may inform individual and couples-based interventions that address the value of benefit finding and incorporate other techniques of positive reappraisal. C1 [Mavandadi, Shahrzad; Sayers, Steven; Weintraub, Daniel] Philadelphia VA Med Ctr, Mental Illness Res Educ & Clin Ctr, Philadelphia, PA USA. [Mavandadi, Shahrzad; Mamikonyan, Eugenia; Sayers, Steven; Weintraub, Daniel] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Dobkin, Roseanne] Rutgers Robert Wood Johnson Med Sch, Dept Psychiat, New Brunswick, NJ USA. [Ten Have, Thomas] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. [Weintraub, Daniel] Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA USA. RP Mavandadi, S (reprint author), 3900 Woodland Ave,116A, Philadelphia, PA 19104 USA. EM Shahrzad.Mavandadi@va.gov NR 41 TC 3 Z9 3 U1 3 U2 10 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0893-3200 EI 1939-1293 J9 J FAM PSYCHOL JI J. Fam. Psychol. PD OCT PY 2014 VL 28 IS 5 BP 728 EP 734 DI 10.1037/a0037847 PG 7 WC Psychology, Clinical; Family Studies SC Psychology; Family Studies GA AX4FE UT WOS:000346888300017 PM 25180468 ER PT J AU Morone, NE Greco, CM AF Morone, Natalia E. Greco, Carol M. TI Adapting Mindfulness Meditation for the Older Adult SO MINDFULNESS LA English DT Editorial Material ID LOW-BACK-PAIN C1 [Morone, Natalia E.] Univ Pittsburgh, Sch Med, Geriatr Res Educ & Clin Ctr, Dept Med,Vet Affairs Pittsburgh Healthcare Syst, Pittsburgh, PA 15213 USA. [Greco, Carol M.] Univ Pittsburgh, Sch Med, Dept Psychiat, Ctr Integrat Med,Med Ctr, Pittsburgh, PA 15213 USA. RP Morone, NE (reprint author), Univ Pittsburgh, Sch Med, Geriatr Res Educ & Clin Ctr, Dept Med,Vet Affairs Pittsburgh Healthcare Syst, 230 McKee Pl,Suite 600, Pittsburgh, PA 15213 USA. EM moronene@upmc.edu NR 7 TC 0 Z9 0 U1 0 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1868-8527 EI 1868-8535 J9 MINDFULNESS JI Mindfulness PD OCT PY 2014 VL 5 IS 5 BP 610 EP 612 DI 10.1007/s12671-014-0297-z PG 3 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AX0IB UT WOS:000346635000016 ER PT J AU Zhao, Z Low, YS Armstrong, NA Ryu, JH Sun, SA Arvanites, AC Hollister-Lock, J Shah, NH Weir, GC Annes, JP AF Zhao, Zhenshan Low, Yen S. Armstrong, Neali A. Ryu, Jennifer Hyoje Sun, Sara A. Arvanites, Anthony C. Hollister-Lock, Jennifer Shah, Nigam H. Weir, Gordon C. Annes, Justin P. TI Repurposing cAMP-Modulating Medications to Promote beta-Cell Replication SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID PANCREATIC MONOLAYER-CULTURES; TYPE-2 DIABETES RISK; INSULIN-SECRETION; CYCLIC-AMP; GLUCOSE-HOMEOSTASIS; SIGNALING PATHWAYS; PRIMARY MECHANISM; FASTING GLUCOSE; KNOCKOUT MICE; HUMAN ISLETS AB Loss of beta-cell mass is a cardinal feature of diabetes. Consequently, developing medications to promote beta-cell regeneration is a priority. cAMP is an intracellular second messenger that modulates beta-cell replication. We investigated whether medications that increase cAMP stability or synthesis selectively stimulate beta-cell growth. To identify cAMP-stabilizing medications that promote beta-cell replication, we performed high-content screening of a phosphodiesterase (PDE) inhibitor library. PDE3, -4, and -10 inhibitors, including dipyridamole, were found to promote beta-cell replication in an adenosine receptor-dependent manner. Dipyridamole's action is specific for beta-cells and not alpha-cells. Next we demonstrated that norepinephrine (NE), a physiologic suppressor of cAMP synthesis in beta-cells, impairs beta-cell replication via activation of alpha(2)-adrenergic receptors. Accordingly, mirtazapine, an alpha(2)-adrenergic receptor antagonist and antidepressant, prevents NE-dependent suppression of beta-cell replication. Interestingly, NE's growth-suppressive effect is modulated by endogenously expressed catecholamine-inactivating enzymes (catechol-O-methyltransferase and L-monoamine oxidase) and is dominant over the growth-promoting effects of PDE inhibitors. Treatment with dipyridamole and/or mirtazapine promote beta-cell replication in mice, and treatment with dipyridamole is associated with reduced glucose levels in humans. This work provides new mechanistic insights into cAMP-dependent growth regulation of beta-cells and highlights the potential of commonly prescribed medications to influence beta-cell growth. C1 [Zhao, Zhenshan; Armstrong, Neali A.; Sun, Sara A.; Annes, Justin P.] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94306 USA. [Zhao, Zhenshan; Armstrong, Neali A.; Sun, Sara A.; Annes, Justin P.] Stanford Univ, Sch Med, Div Endocrinol Gerontol & Metab, Stanford, CA 94306 USA. [Low, Yen S.] Stanford Univ, Sch Med, Stanford Ctr Biomed Informat Res, Stanford, CA 94306 USA. [Ryu, Jennifer Hyoje; Arvanites, Anthony C.] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA. [Hollister-Lock, Jennifer; Weir, Gordon C.] Harvard Univ, Sch Med, Dept Med, Sect Islet Cell & Regenerat Biol,Joslin Diabet Ct, Boston, MA 02115 USA. RP Annes, JP (reprint author), Stanford Univ, Sch Med, Dept Med, CCSR 2255-A,1291 Welch Rd, Stanford, CA 94306 USA. EM jannes@stanford.edu FU National Institutes of Health [DK084206, DK098143, DK090781]; Juvenile Diabetes Research Foundation FX This work was supported by National Institutes of Health Grants DK084206 and DK098143 (to J.P.A.) and DK090781 (from Douglas A. Melton). This research was performed with the support of the Network for Pancreatic Organ Donors with Diabetes (nPOD), a collaborative type 1 diabetes research project sponsored by the Juvenile Diabetes Research Foundation. Organ Procurement Organizations partnering with nPOD to provide research resources are listed at www.jdrfnpod.org/ourpartners.php. Human islets were provided by the National Human Tissue Resource Center. NR 71 TC 8 Z9 8 U1 0 U2 3 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD OCT PY 2014 VL 28 IS 10 BP 1682 EP 1697 DI 10.1210/me.2014-1120 PG 16 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AX3KA UT WOS:000346837000010 PM 25083741 ER PT J AU Lisse, TS Saini, V Zhao, H Luderer, HF Gori, F Demay, MB AF Lisse, Thomas S. Saini, Vaibhav Zhao, Hengguang Luderer, Hilary F. Gori, Francesca Demay, Marie B. TI The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID HAIR FOLLICLE MORPHOGENESIS; SONIC-HEDGEHOG; STEM-CELLS; KNOCKOUT MICE; GENE-EXPRESSION; WNT SIGNALS; DIFFERENTIATION; ALOPECIA; SKIN; PATHWAY AB Alopecia (hair loss) in vitamin D receptor (VDR)-null mice is due to absence of ligand-independent actions of the VDR that are required for initiation of postmorphogenic hair cycles. Investigations were undertaken to determine whether the VDR is required for the induction of signaling pathways that play an important role in this process. The induction of cWnt and hedgehog target genes that characterizes early anagen was found to be dramatically attenuated in VDR-/- mice, relative to wild-type (WT) mice. To determine whether this reflects impaired responsiveness to cWnt ligands, in vitro studies were performed in primary keratinocytes. These studies demonstrated impaired induction of cWnt target genes in response to Wnt3a in VDR-/- keratinocytes, relative to wild-type keratinocytes. Chromatin immunoprecipitation analyses revealed that the VDR was recruited to the regulatory regions of cWnt and hedgehog target genes in WT keratinocytes but not in VDR-/- or Lef1(-/-) keratinocytes. Lef1 was enriched on these same regulatory regions in WT keratinocytes but not in VDR-/- keratinocytes. In vivo studies were performed to determine whether activation of the hedgehog pathway could bypass the defect in cWnt signaling observed in the absence of the unliganded VDR. In WT, but not VDR-/-, mice, hedgehog agonist treatment resulted in an induction of cWnt and hedgehog target genes and the generation of mature anagen hair follicles. Thus, these studies demonstrate that the unliganded VDR interacts with regulatory regions in the cWnt and hedgehog target genes and is required for the induction of these pathways during the postnatal hair cycle. C1 [Demay, Marie B.] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA. Harvard Univ, Sch Med, Boston, MA 02114 USA. RP Demay, MB (reprint author), Massachusetts Gen Hosp, Endocrine Unit, Thier 1101,50 Blossom St, Boston, MA 02114 USA. EM demay@helix.mgh.harvard.edu FU NIH [R01 DK46974, F32AR056933]; Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University FX This work was supported by This work was funded by grants from the NIH to MBD (R01 DK46974) and HFL (F32AR056933) and a research fellowship from the Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University to HGZ.. NR 34 TC 8 Z9 8 U1 0 U2 2 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD OCT PY 2014 VL 28 IS 10 BP 1698 EP 1706 DI 10.1210/me.2014-1043 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AX3KA UT WOS:000346837000011 PM 25180455 ER PT J AU Liu, M Goss, PE Ingle, JN Kubo, M Furukawa, Y Batzler, A Jenkins, GD Carlson, EE Nakamura, Y Schaid, DJ Chapman, JAW Shepherd, LE Ellis, MJ Khosla, S Wang, L Weinshilboum, RM AF Liu, Mohan Goss, Paul E. Ingle, James N. Kubo, Michiaki Furukawa, Yoichi Batzler, Anthony Jenkins, Gregory D. Carlson, Erin E. Nakamura, Yusuke Schaid, Daniel J. Chapman, Judy-Anne W. Shepherd, Lois E. Ellis, Matthew J. Khosla, Sundeep Wang, Liewei Weinshilboum, Richard M. TI Aromatase Inhibitor-Associated Bone Fractures: A Case-Cohort GWAS and Functional Genomics SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID EARLY BREAST-CANCER; POSTMENOPAUSAL WOMEN; WIDE ASSOCIATION; MINERAL DENSITY; CATHEPSIN-K; PHASE-III; OSTEOPOROSIS; ANASTROZOLE; EXPRESSION; TRIAL AB Bone fractures are a major consequence of osteoporosis. There is a direct relationship between serum estrogen concentrations and osteoporosis risk. Aromatase inhibitors (AIs) greatly decrease serum estrogen levels in postmenopausal women, and increased incidence of fractures is a side effect of AI therapy. We performed a discovery case-cohort genome-wide association study (GWAS) using samples from 1071 patients, 231 cases and 840 controls, enrolled in the MA. 27 breast cancer AI trial to identify genetic factors involved in AI-related fractures, followed by functional genomic validation. Association analyses identified 20 GWAS single nucleotide polymorphism (SNP) signals with P < 5E-06. After removal of signals in gene deserts and those composed entirely of imputed SNPs, we applied a functional validation "decision cascade" that resulted in validation of the CTSZ-SLMO2-ATP5E, TRAM2-TMEM14A, and MAP4K4 genes. These genes all displayed estradiol (E2)-dependent induction in human fetal osteoblasts transfected with estrogen receptor-alpha, and their knockdown altered the expression of known osteoporosis-related genes. These same genes also displayed SNP-dependent variation in E2 induction that paralleled the SNP-dependent induction of known osteoporosis genes, such as osteoprotegerin. In summary, our case-cohort GWAS identified SNPs in or near CTSZ-SLMO2-ATP5E, TRAM2-TMEM14A, and MAP4K4 that were associated with risk for bone fracture in estrogen receptor-positive breast cancer patients treated with AIs. These genes displayed E2-dependent induction, their knockdown altered the expression of genes related to osteoporosis, and they displayed SNP genotype-dependent variation in E2 induction. These observations may lead to the identification of novel mechanisms associated with fracture risk in postmenopausal women treated with AIs. C1 [Liu, Mohan; Wang, Liewei; Weinshilboum, Richard M.] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Div Clin Pharmacol, Rochester, MN 55905 USA. [Ingle, James N.] Mayo Clin, Dept Oncol, Rochester, MN 55905 USA. [Batzler, Anthony; Jenkins, Gregory D.; Carlson, Erin E.; Schaid, Daniel J.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA. [Khosla, Sundeep] Mayo Clin, Div Endocrinol, Rochester, MN 55905 USA. [Goss, Paul E.] Harvard Univ, Massachusetts Gen Hosp, Boston, MA 02114 USA. [Kubo, Michiaki; Furukawa, Yoichi] Rikagaku Kenkyusho Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan. [Nakamura, Yusuke] Univ Chicago, Sch Med, Chicago, IL 60637 USA. [Chapman, Judy-Anne W.; Shepherd, Lois E.] Natl Canc Inst Canada Clin Trials Grp, Kingston, ON K7L 3N6, Canada. [Ellis, Matthew J.] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA. RP Weinshilboum, RM (reprint author), Mayo Clin, 200 First St SW, Rochester, MN 55905 USA. EM weinshilboum.richard@mayo.edu RI Kubo, Michiaki/N-7947-2015; OI Khosla, Sundeep/0000-0002-2936-4372 FU National Institutes of Health (Pharmacogenomics Research Network) [U19 GM61388, U01 HG005137, R01 CA138461, R01 CA133049, P50 CA166201]; Pharmaceutical Research and Manufacturers of America Foundation Center of Excellence in Clinical Pharmacology award; Mayo Center for Individualized Medicine; Rikagaku Kenkyusho Center for Integrative Medical Science; Biobank Japan Project - Ministry of Education, Culture, Sports, and Technology, Japan; Avon Foundation, New York FX This work was supported in part by National Institutes of Health Grants U19 GM61388 (The Pharmacogenomics Research Network), U01 HG005137, R01 CA138461, R01 CA133049, and P50 CA166201 (Mayo Clinic Breast Cancer Specialized Program of Research Excellence); a Pharmaceutical Research and Manufacturers of America Foundation Center of Excellence in Clinical Pharmacology award; the Mayo Center for Individualized Medicine; and the Rikagaku Kenkyusho Center for Integrative Medical Science and the Biobank Japan Project funded by the Ministry of Education, Culture, Sports, and Technology, Japan. P. E. G. is supported in part by the Avon Foundation, New York; ClinicalTrials.gov study NCT00283608. NR 40 TC 10 Z9 12 U1 1 U2 3 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD OCT PY 2014 VL 28 IS 10 BP 1740 EP 1751 DI 10.1210/me.2014-1147 PG 12 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AX3KA UT WOS:000346837000015 PM 25148458 ER PT J AU Van Allen, EM Mouw, KW Kim, P Iyer, G Wagle, N Al-Ahmadie, H Zhu, C Ostrovnaya, I Kryukov, GV O'Connor, KW Sfakianoss, J Garcia-Grossman, I Kim, J Guancial, EA Bambury, R Bahl, S Gupta, N Farlow, D Qu, A Signoretti, S Barletta, JA Reuter, V Boehm, J Lawrence, M Getz, G Kantoff, P Bochner, BH Choueiri, TK Bajorin, DF Solit, DB Gabriel, S D'Andrea, A Garraway, LA Rosenberg, JE AF Van Allen, Eliezer M. Mouw, Kent W. Kim, Philip Iyer, Gopa Wagle, Nikhil Al-Ahmadie, Hikmat Zhu, Cong Ostrovnaya, Irina Kryukov, Gregory V. O'Connor, Kevin W. Sfakianoss, John Garcia-Grossman, Ilana Kim, Jaegil Guancial, Elizabeth A. Bambury, Richard Bahl, Samira Gupta, Namrata Farlow, Deborah Qu, Angela Signoretti, Sabina Barletta, Justine A. Reuter, Victor Boehm, Jesse Lawrence, Michael Getz, Gad Kantoff, Philip Bochner, Bernard H. Choueiri, Toni K. Bajorin, Dean F. Solit, David B. Gabriel, Stacey D'Andrea, Alan Garraway, Levi A. Rosenberg, Jonathan E. TI Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma SO CANCER DISCOVERY LA English DT Article ID INTEGRATIVE GENOMICS VIEWER; CELL LUNG-CANCER; BLADDER-CANCER; NEOADJUVANT CHEMOTHERAPY; DNA-REPAIR; RADICAL CYSTECTOMY; RANDOMIZED-TRIAL; EXCISION-REPAIR; SEQUENCING DATA; PLUS CISPLATIN AB Cisplat in-based chemotherapy is the standard of care for patients with muscle-invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, although molecular determinants of cisplatin response are incompletely understood. We performed whole-exome sequencing on pretreatment tumor and germline DNA from 50 patients with muscle-invasive urothelial carcinoma who received neoadjuvant cisplatin-based chemotherapy followed by cystectomy (25 pT0/pTis "responders," 25 pT2+ "nonresponders") to identify somatic mutations that occurred preferentially in responders. ERCC2. a nucleotide excision repair gene, was the only significantly mutated gene enriched in the cisplatin responders compared with nonresponders (q < 0.01). Expression of representative ERCC2 mutants in an ERCC2-deficient cell line failed to rescue cisplatin and UV sensitivity compared with wild-type ERCC2. The lack of normal ERCC2 function may contribute to cisplatin sensitivity in urothelial cancer, and somatic ERCC2 mutation status may inform cisplatin-containing regimen usage in muscle-invasive urothelial carcinoma. SIGNIFICANCE: Somatic ERCC2 mutations correlate with complete response to cisplatin-based chemosensitivity in muscle-invasive urothelial carcinoma, and clinically identified mutations lead to cisplatin sensitivity in vitro. Nucleotide excision repair pathway defects may drive exceptional response to conventional chemotherapy. (C) 2014 AACR. C1 [Van Allen, Eliezer M.; Wagle, Nikhil; Qu, Angela; Kantoff, Philip; Choueiri, Toni K.; Gabriel, Stacey; Garraway, Levi A.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Van Allen, Eliezer M.; Wagle, Nikhil; Zhu, Cong; Kryukov, Gregory V.; Kim, Jaegil; Bahl, Samira; Gupta, Namrata; Farlow, Deborah; Boehm, Jesse; Lawrence, Michael; Getz, Gad; Garraway, Levi A.] MIT, Broad Inst, Cambridge, MA 02139 USA. [Van Allen, Eliezer M.; Wagle, Nikhil; Zhu, Cong; Kryukov, Gregory V.; Kim, Jaegil; Bahl, Samira; Gupta, Namrata; Farlow, Deborah; Boehm, Jesse; Lawrence, Michael; Getz, Gad; Garraway, Levi A.] Harvard, Cambridge, MA USA. [Mouw, Kent W.; O'Connor, Kevin W.; D'Andrea, Alan] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA. [Mouw, Kent W.; D'Andrea, Alan] Harvard Radiat Oncol Program, Boston, MA USA. [Kim, Philip; Sfakianoss, John; Bochner, Bernard H.] Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, New York, NY 10021 USA. [Iyer, Gopa; Al-Ahmadie, Hikmat; Reuter, Victor; Bochner, Bernard H.; Bajorin, Dean F.; Solit, David B.; Rosenberg, Jonathan E.] Cornell Univ, Weill Cornell Med Coll, New York, NY 10021 USA. [Iyer, Gopa; Garcia-Grossman, Ilana; Bambury, Richard; Bajorin, Dean F.; Rosenberg, Jonathan E.] Mem Sloan Kettering Canc Ctr, Dept Med, Genitourinary Oncol Serv, New York, NY 10021 USA. [Al-Ahmadie, Hikmat; Reuter, Victor] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. [Ostrovnaya, Irina] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Guancial, Elizabeth A.] Univ Rochester, Med Ctr, Sch Med & Dent, Div Hematol Oncol,Dept Med, Rochester, NY 14642 USA. [Signoretti, Sabina; Barletta, Justine A.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA. [Getz, Gad] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Getz, Gad] Dept Pathol, Boston, MA USA. [Solit, David B.] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA. RP Rosenberg, JE (reprint author), Mem Sloan Kettering Canc Ctr, Genitourinary Oncol Serv, 1275 York Ave, New York, NY 10065 USA. EM levi_garraway@dfci.harvard.edu; rosenbj1@mskcc.org RI Kryukov, Gregory/A-9592-2008; OI Boehm, Jesse/0000-0002-6795-6336; Al-Ahmadie, Hikmat/0000-0002-2938-6627; Rosenberg, Jonathan/0000-0003-2637-4249 FU Dana-Barber Leadership Council; American Cancer Society; Conquer Cancer Foundation; NIH/National Human Genome Research Institute [U54HG003067]; Cycle for Survival; Geoffrey Beene Cancer Research Center; Starr Cancer Consortium FX This study was supported by the Dana-Barber Leadership Council (Co E.M. Van Allen), the American Cancer Society (to EM. Van Allen), the Conquer Cancer Foundation (to E.M. Van Allen and K.W. Mouw), the NIH/National Human Genome Research Institute (U54HG003067, ro LA. Garraway and S. Gabriel), Cycle for Survival (Co C Iyer, I.Ostrovnaya, and B.H. Bochner), the Geoffrey Beene Cancer Research Center (to J.E. Rosenberg, D.B. Soilt, II. Al-Ahmadie, and I. Ostrovnaya), and the Starr Cancer Consortium (to J.E. Rosenberg, EM. Van Allen, G. her, I,A. Garraway, I. Ostrovnaya, and H. Al-Ahmadie). NR 39 TC 68 Z9 68 U1 2 U2 12 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 2159-8274 EI 2159-8290 J9 CANCER DISCOV JI Cancer Discov. PD OCT PY 2014 VL 4 IS 10 BP 1140 EP 1153 DI 10.1158/2159-8290.CD-14-0623 PG 14 WC Oncology SC Oncology GA AW8GP UT WOS:000346499800023 PM 25096233 ER PT J AU Stoeck, A Lejnine, S Truong, A Pan, L Wang, HF Zang, CZ Yuan, J Ware, C MacLean, J Garrett-Engele, PW Kluk, M Laskey, J Haines, BB Moskaluk, C Zawel, L Fawell, S Gilliland, G Zhang, T Kremer, BE Knoechel, B Bernstein, BE Pear, WS Liu, XS Aster, JC Sathyanarayanan, S AF Stoeck, Alexander Lejnine, Sergui Truong, Andrew Pan, Li Wang, Hongfang Zang, Chongzhi Yuan, Jing Ware, Chris MacLean, John Garrett-Engele, Philip W. Kluk, Michael Laskey, Jason Haines, Brian B. Moskaluk, Christopher Zawel, Leigh Fawell, Stephen Gilliland, Gary Zhang, Theresa Kremer, Brandon E. Knoechel, Birgit Bernstein, Bradley E. Pear, Warren S. Liu, X. Shirley Aster, Jon C. Sathyanarayanan, Sriram TI Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma SO CANCER DISCOVERY LA English DT Article ID LYMPHOBLASTIC-LEUKEMIA-CELLS; C-MYC; MUTATIONAL LANDSCAPE; TARGETED THERAPIES; NOTCH1 INHIBITION; ACTIVATION; GENE; PATHWAY; EXPRESSION; RESISTANCE AB Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to constitutive receptor activation were confined to triple-negative breast cancers (TNBC; 6 of 66 tumors). TNBC cell lines with NOTCH1 rearrangements associated with high levels of activated NOTCH1 (N1-ICD) were sensitive to the gamma-secretase inhibitor (GSI) MRK-003, both alone and in combination with paclitaxel, in vitro and in vivo, whereas cell lines with NOTCH2 rearrangements were resistant to GSI. Immunohistochemical staining of N1-ICD in TNBC xenografts correlated with responsiveness, and expression levels of the direct Notch target gene HES4 correlated with outcome in patients with TNBC. Activating NOTCH1 point mutations were also identified in other solid tumors, including adenoid cystic carcinoma (ACC). Notably, ACC primary tumor xenografts with activating NOTCH1 mutations and high N1-ICD levels were sensitive to GSI, whereas N1-ICD-low tumors without NOTCH1 mutations were resistant. SIGNIFICANCE: NOTCH1 mutations, immunohistochemical staining for activated NOTCH1, and HES4 expression are biomarkers that can be used to identify solid tumors that are likely to respond to GSI-based therapies. (C) 2014 AACR. C1 [Stoeck, Alexander; Lejnine, Sergui; Truong, Andrew; Yuan, Jing; Ware, Chris; MacLean, John; Garrett-Engele, Philip W.; Laskey, Jason; Haines, Brian B.; Zawel, Leigh; Fawell, Stephen; Gilliland, Gary; Zhang, Theresa; Sathyanarayanan, Sriram] Merck Res Lab, Boston, MA USA. [Pan, Li; Wang, Hongfang; Kluk, Michael; Aster, Jon C.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Pan, Li; Wang, Hongfang; Kluk, Michael; Knoechel, Birgit; Bernstein, Bradley E.; Aster, Jon C.] Harvard Univ, Sch Med, Boston, MA USA. [Zang, Chongzhi; Liu, X. Shirley] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Moskaluk, Christopher] Univ Virginia, Dept Med, Charlottesville, VA USA. [Moskaluk, Christopher] Univ Virginia, Digest Hlth Res Ctr, Charlottesville, VA USA. [Kremer, Brandon E.; Pear, Warren S.] Univ Penn, Perelman Sch Med, Dept Pathol, Philadelphia, PA 19104 USA. [Knoechel, Birgit; Bernstein, Bradley E.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Knoechel, Birgit; Bernstein, Bradley E.] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA. RP Sathyanarayanan, S (reprint author), Jounce Therapeut, 1030 Massachusetts Ave, Cambridge, MA 02138 USA. EM Alexander.Stoeck@merck.com; jaster@rics.bwh.harvard.edu; ssathy@jouncetx.com RI Zang, Chongzhi/D-1445-2011 FU Merck Co., Inc.; NIH P01 grant [5P01CA119070-08]; Abramson Cancer Center Support Grant from the NCI; Adenoid Cystic Carcinoma Research Foundation; NIH K32 Grant [CA009615] FX The majority of this work was funded by Merck & Co., Inc. J.C. Aster and W.S. Pear were supported by NIH P01 grant (5P01CA119070-08) and W.S. Pear was supported in part by an Abramson Cancer Center Support Grant from the NCI. B.E. Bernstein acknowledges support from the Adenoid Cystic Carcinoma Research Foundation. B.E. Kremer is supported by NIH K32 Grant CA009615. NR 35 TC 27 Z9 27 U1 1 U2 5 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 2159-8274 EI 2159-8290 J9 CANCER DISCOV JI Cancer Discov. PD OCT PY 2014 VL 4 IS 10 BP 1154 EP 1167 DI 10.1158/2159-8290.CD-13-0830 PG 14 WC Oncology SC Oncology GA AW8GP UT WOS:000346499800024 PM 25104330 ER PT J AU Smith, MP Sanchez-Laorden, B O'Brien, K Brunton, H Ferguson, J Young, H Dhomen, N Flaherty, KT Frederick, DT Cooper, ZA Wargo, JA Marais, R Wellbrock, C AF Smith, Michael P. Sanchez-Laorden, Berta O'Brien, Kate Brunton, Holly Ferguson, Jennifer Young, Helen Dhomen, Nathalie Flaherty, Keith T. Frederick, Dennie T. Cooper, Zachary A. Wargo, Jennifer A. Marais, Richard Wellbrock, Claudia TI The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNF alpha SO CANCER DISCOVERY LA English DT Article ID NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; HUMAN METASTATIC MELANOMA; BRAF INHIBITION; RAF INHIBITORS; ANTITUMOR-ACTIVITY; MASTER REGULATOR; T-CELLS; CANCER; MICE AB Recently, the rationale for combining targeted therapy with immunotherapy has come to light, but our understanding of the immune response during MAPK pathway inhibitor treatment is limited. We discovered that the immune microenvironment can act as a source of resistance to MAPK pathway-targeted therapy, and moreover during treatment this source becomes reinforced. In particular, we identified macrophage-derived TNF alpha as a crucial melanoma growth factor that provides resistance to MAPK pathway inhibitors through the lineage transcription factor MITF (microphthalmia transcription factor). Most strikingly, in BRAF-mutant melanomas of patients and BRAF(V600E) melanoma allografts, MAPK pathway inhibitors increased the number of tumor-associated macrophages, and TNF alpha and MITF expression. Inhibiting TNF alpha signaling with I kappa B kinase inhibitors profoundly enhanced the efficacy of MAPK pathway inhibitors by targeting not only the melanoma cells but also the microenvironment. In summary, we identify the immune microenvironment as a novel source of resistance and reveal a new strategy to improve the efficacy of targeted therapy in melanoma. SIGNIFICANCE: This study identifies the immune microenvironment as a source of resistance to MAPK pathway inhibitors through macrophage-derived TNF alpha, and reveals that in patients on treatment this source becomes reinforced. Inhibiting I kappa B kinase enhances the efficacy of MAPK pathway inhibitors, which identifies this approach as a potential novel strategy to improve targeted therapy in melanoma. (C) 2014 AACR. C1 [Smith, Michael P.; Brunton, Holly; Ferguson, Jennifer; Young, Helen; Wellbrock, Claudia] Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester Canc Res Ctr, Manchester M13 9PT, Lancs, England. [Sanchez-Laorden, Berta; O'Brien, Kate; Dhomen, Nathalie; Marais, Richard] Inst Canc Res, Chester Beatty Labs, Div Canc Biol, London SW3 6JB, England. [Sanchez-Laorden, Berta; Marais, Richard] Univ Manchester, Canc Res UK Manchester Inst, Mol Oncol Grp, Manchester M13 9PT, Lancs, England. [Flaherty, Keith T.; Frederick, Dennie T.] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Cooper, Zachary A.; Wargo, Jennifer A.] Univ Texas MD Anderson Canc Ctr, Div Surg Oncol, Houston, TX 77030 USA. RP Wellbrock, C (reprint author), Univ Manchester, Michael Smith Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England. EM Claudia.Wellbrock@manchester.ac.uk FU Cancer Research UK [C11591/A16416, C15759/A12328, C107/A10433]; Wellcome Trust Institutional Strategic Support Fund (ISSF) award [097820/Z/11/B]; NCI/NIH [U54CA163125] FX This work was supported by funding from Cancer Research UK (C11591/A16416, to C. Wellbrock; C15759/A12328 and C107/A10433, to R. Marais), a Wellcome Trust Institutional Strategic Support Fund (ISSF) award (097820/Z/11/B) to the University of Manchester, and an NCI/NIH U54CA163125 grant to J.A. Wargo and K.T. Flaherty. NR 50 TC 29 Z9 30 U1 3 U2 17 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 2159-8274 EI 2159-8290 J9 CANCER DISCOV JI Cancer Discov. PD OCT PY 2014 VL 4 IS 10 BP 1214 EP 1229 DI 10.1158/2159-8290.CD-13-1007 PG 16 WC Oncology SC Oncology GA AW8GP UT WOS:000346499800028 PM 25256614 ER PT J AU Pashtan, I Chen, MH D'Amico, AV AF Pashtan, Itai Chen, Ming-Hui D'Amico, Anthony V. TI The impact of PSA and digital rectal examination on the risk of prostate cancer specific mortality in men with a PSA level <2.5 ng/ml SO CANCER EPIDEMIOLOGY LA English DT Article DE Prostate cancer; Low PSA; Digital rectal examination; Prostate cancer specific mortality; SEER program ID BEAM RADIATION-THERAPY; SMALL-CELL CARCINOMA; RADICAL PROSTATECTOMY; ANTIGEN LEVEL; GLEASON SCORE; PREVALENCE; RECURRENCE; VELOCITY; OUTCOMES; DISEASE AB Introduction: It is unknown whether a normal range, diagnostic serum prostate specific antigen (PSA) level's influence on prostate cancer specific mortality (PCSM) is dependent upon digital rectal examination (DRE) findings. Methods: Between 2004 and 2007, 9081 men diagnosed with non-palpable (T1c, N = 1710) or palpable (T2-T4, N = 7371) and non-metastatic prostate cancer (PC) were identified from surveillance, epidemiology, and end results data, selected based on pre-treatment PSA < 2.5 ng/ml. A multivariable competing risks regression model evaluated whether DRE findings interacted with PSA level in predicting risk of PCSM. Results: After median follow-up of 2.83 years, 118 of 548 deaths (21.5%) were due to PC. Increasing diagnostic PSA was associated with increased risk of PCSM (AHR = 3.52; 95% CI: 1.25-9.89; P = .017) in men with T1c, Gleason score 7-10 PC, but decreased PCSM risk (AHR = 0.66; 95% CI: 0.52-0.83; P < .001) for men with T2-T4 PC and any Gleason score. Discussion: For men with diagnostic PSA level <2.5 ng/ml and palpable PC, risk of early PCSM increases by 34% for a 1 point decrease in PSA from 2. This suggests the existence of clinically detectable, low PSA secreting disease with an elevated risk of early PCSM, highlighting the importance of the DRE in men with PC and normal range, diagnostic PSA. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Pashtan, Itai; D'Amico, Anthony V.] Brigham & Womens Hosp, Dept Radiat Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA. [Chen, Ming-Hui] Univ Connecticut, Dept Stat, Storrs, CT 06269 USA. RP Pashtan, I (reprint author), Brigham & Womens Hosp, Dept Radiat Oncol, L-2 Level,75 Francis St, Boston, MA 02115 USA. EM ipashtan@partners.org NR 35 TC 1 Z9 1 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1877-7821 EI 1877-783X J9 CANCER EPIDEMIOL JI Cancer Epidemiol. PD OCT PY 2014 VL 38 IS 5 BP 613 EP 618 DI 10.1016/j.canep.2014.07.007 PG 6 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA AW8HW UT WOS:000346503300022 PM 25164550 ER PT J AU Kingston, RE Tamkun, JW AF Kingston, Robert E. Tamkun, John W. TI Transcriptional Regulation by Trithorax-Group Proteins SO COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY LA English DT Article ID CHROMATIN REMODELING COMPLEX; POLYCOMB GROUP REPRESSION; YEAST SWI/SNF COMPLEX; RNA-POLYMERASE-II; HISTONE H3; CHARGE-SYNDROME; HOMEOTIC GENE; SACCHAROMYCES-CEREVISIAE; DROSOPHILA DEVELOPMENT; ACTIVE CHROMATIN AB The trithorax group of genes (trxG) was identified in mutational screens that examined developmental phenotypes and suppression of Polycomb mutant phenotypes. The protein products of these genes are primarily involved in gene activation, although some can also have repressive effects. There is no central function for these proteins. Some move nucleosomes about on the genome in an ATP-dependent manner, some covalently modify histones such as methylating lysine 4 of histone H3, and some directly interact with the transcription machinery or are a part of that machinery. It is interesting to consider why these specific members of large families of functionally related proteins have strong developmental phenotypes. C1 [Kingston, Robert E.] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. [Tamkun, John W.] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA. RP Kingston, RE (reprint author), Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. EM kingston@molbio.mgh.harvard.edu FU NIGMS NIH HHS [R37 GM048405, R01 GM049883] NR 103 TC 12 Z9 12 U1 1 U2 13 PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT PI COLD SPRING HARBOR PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA SN 1943-0264 J9 CSH PERSPECT BIOL JI Cold Spring Harbor Perspect. Biol. PD OCT PY 2014 VL 6 IS 10 AR a019349 DI 10.1101/cshperspect.a019349 PG 18 WC Cell Biology SC Cell Biology GA AW7MS UT WOS:000346448700001 PM 25274705 ER PT J AU McKeown, MR Bradner, JE AF McKeown, Michael R. Bradner, James E. TI Therapeutic Strategies to Inhibit MYC SO COLD SPRING HARBOR PERSPECTIVES IN MEDICINE LA English DT Article ID BET BROMODOMAIN INHIBITION; G-QUADRUPLEX STRUCTURES; C-MYC/MAX DIMERIZATION; PROTEIN-PROTEIN INTERACTIONS; ACUTE LYMPHOBLASTIC-LEUKEMIA; SMALL-MOLECULE INHIBITION; ACUTE MYELOID-LEUKEMIA; PIM-1 TRANSGENIC MICE; TRANSCRIPTIONAL ACTIVATION; SELECTIVE-INHIBITION AB MYC is a master regulator of stem cell state, embryogenesis, tissue homeostasis, and aging. As in health, in disease MYC figures prominently. Decades of biological research have identified a central role for MYC in the pathophysiology of cancer, inflammation, and heart disease. The centrality of MYC to such a vast breadth of disease biology has attracted significant attention to the historic challenge of developing inhibitors of MYC. This review will discuss therapeutic strategies toward the development of inhibitors of MYC-dependent transcriptional signaling, efforts to modulate MYC stability, and the elusive goal of developing potent, direct-acting inhibitors of MYC. C1 [McKeown, Michael R.; Bradner, James E.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. [Bradner, James E.] Broad Inst, Ctr Sci Therapeut, Cambridge, MA 02141 USA. [Bradner, James E.] Harvard Univ, Dept Med, Sch Med, Boston, MA 02115 USA. RP Bradner, JE (reprint author), Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. EM james_bradner@dfci.harvard.edu NR 138 TC 15 Z9 15 U1 0 U2 6 PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT PI COLD SPRING HARBOR PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA SN 2157-1422 J9 CSH PERSPECT MED JI Cold Spring Harb. Perspect. Med. PD OCT PY 2014 VL 4 IS 10 AR a014266 DI 10.1101/cshperspect.a014266 PG 16 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA AW8OI UT WOS:000346521400006 ER PT J AU Schmitt, L Bui, E Letamendia, C AF Schmitt, Laurent Bui, Eric Letamendia, Clara TI The creative escape from physical prisons SO EVOLUTION PSYCHIATRIQUE LA French DT Article DE Body; Motor handicap; Psychosomatic; Creativity; Art; Sami-Ali AB The present work aims to understand the creative impetus that has sometimes been described in response to one's body being paralysed. When this occurs the individuals experience many internal disruptions, and therefore need to find a new psychological equilibrium. How do they find a way to rebuild themselves? How and why create, when the body has been changed, mutilated, disabled, and when the slightest movement in everyday life becomes difficult? How can we understand this creative escape? Method and results. - Through many now recognized artists' work, such as those of Joe Bousquet, Frida Kahlo, Grand Corps Malade, Guilaume de Fonclare, and Jean-Dominique Bauby, we illustrate the way in which some authors have developed a rich imagination and operated fabulous creative processes. In line with the relational psychosomatic approach of Sami-Ali, this article aims to detail the various aspects that "the creative escape" may cover, by exposing the concepts of intellectual escape, escape by reverie and escape by sentimental idyll. Discussion and Conclusion. - This paper presents an original approach to the experiences of those who have become paralysed and have developed an outstanding creative energy. The body becomes an object of fiction, true support of creative activity. In addition, our work finds the concept of the creation as a psychosomatic act, through the notions of passage from the commonplace to the imaginary, mutual inclusion and physical dead end. (C) 2014 Elsevier Masson SAS. All rights reserved. C1 [Schmitt, Laurent; Letamendia, Clara] CHU Toulouse, Serv Psychiat & Psychol Med, TSA 70034, F-31059 Toulouse 9, France. [Schmitt, Laurent; Bui, Eric; Letamendia, Clara] Fac Med Rangueil, F-31400 Toulouse, France. [Bui, Eric] Massachusetts Gen Hosp, Ctr Anxiety & Traumat Stress Disorders, Boston, MA 02114 USA. [Bui, Eric] Harvard Univ, Sch Med, Boston, MA 02115 USA. RP Letamendia, C (reprint author), CHU Toulouse, Serv Psychiat & Psychol Med, TSA 70034, 330 Ave Grande Bretagne, F-31059 Toulouse 9, France. EM letamendia.c@chu-toulouse.fr RI Bui, Eric/J-8347-2015 OI Bui, Eric/0000-0002-1413-6473 NR 12 TC 0 Z9 0 U1 0 U2 8 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0014-3855 EI 1769-6674 J9 EVOL PSYCHIATR JI Evol. Psychiatr. PD OCT-DEC PY 2014 VL 79 IS 4 BP 715 EP 724 DI 10.1016/j.evopsy.2014.01.004 PG 10 WC Psychiatry SC Psychiatry GA AW7QC UT WOS:000346458700009 ER PT J AU Dranoff, G AF Dranoff, Glenn TI A New Cancer Immunology Research Special Feature: Perspective from a Master of Immunology SO CANCER IMMUNOLOGY RESEARCH LA English DT Editorial Material C1 Dana Farber Canc Inst, Boston, MA 02115 USA. RP Dranoff, G (reprint author), Dana Farber Canc Inst, Boston, MA 02115 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 2326-6066 EI 2326-6074 J9 CANCER IMMUNOL RES JI Cancer Immunol. Res. PD OCT PY 2014 VL 2 IS 10 BP 925 EP 925 DI 10.1158/2326-6066.CIR-14-0166 PG 1 WC Oncology; Immunology SC Oncology; Immunology GA AW2QR UT WOS:000346134100001 PM 25281319 ER PT J AU Kim, HJ Cantor, H AF Kim, Hye-Jung Cantor, Harvey TI The Path to Reactivation of Antitumor Immunity and Checkpoint Immunotherapy SO CANCER IMMUNOLOGY RESEARCH LA English DT Article ID REGULATORY T-CELLS; IMMUNOLOGICAL GENOME PROJECT; CTLA-4 COUNTER-RECEPTOR; CHRONIC VIRAL-INFECTION; NATURAL-KILLER-CELL; TUMOR MICROENVIRONMENT; IN-VITRO; PROGRAMMED DEATH-1; CD28 SUPERAGONIST; MONOCLONAL-ANTIBODIES AB Cancer immunology has recently made major therapeutic inroads that represent clinical application of basic insights into mechanisms that govern immunity against tumors. Research into fundamental elements of T-cell and natural killer-cell biology, including the basis of antigen recognition, activation, proliferation, and survival, has informed the design of new therapeutic approaches to augment the body's natural anticancer immune response. Here, we describe some of the key steps that have provided the foundation for current strategies of immunotherapy. (C)2014 AACR. C1 [Kim, Hye-Jung; Cantor, Harvey] Dana Farber Canc Inst, Dept Canc Immunol, Boston, MA 02215 USA. [Kim, Hye-Jung; Cantor, Harvey] Dana Farber Canc Inst, AIDS, Boston, MA 02215 USA. [Kim, Hye-Jung; Cantor, Harvey] Harvard Univ, Sch Med, Dept Microbiol & Immunol, Div Immunol, Boston, MA USA. RP Cantor, H (reprint author), Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA. EM Harvey_Cantor@dfci.harvard.edu FU LeRoy Schecter Research Foundation FX This activity was supported by a gift from the LeRoy Schecter Research Foundation. NR 159 TC 8 Z9 8 U1 2 U2 11 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 2326-6066 EI 2326-6074 J9 CANCER IMMUNOL RES JI Cancer Immunol. Res. PD OCT PY 2014 VL 2 IS 10 BP 926 EP 936 DI 10.1158/2326-6066.CIR-14-0153 PG 11 WC Oncology; Immunology SC Oncology; Immunology GA AW2QR UT WOS:000346134100002 PM 25281320 ER PT J AU McNeel, DG Gardner, TA Higano, CS Kantoff, PW Small, EJ Wener, MH Sims, RB DeVries, T Sheikh, NA Dreicer, R AF McNeel, Douglas G. Gardner, Thomas A. Higano, Celestia S. Kantoff, Philip W. Small, Eric J. Wener, Mark H. Sims, Robert B. DeVries, Todd Sheikh, Nadeem A. Dreicer, Robert TI A Transient Increase in Eosinophils Is Associated with Prolonged Survival in Men with Metastatic Castration-Resistant Prostate Cancer Who Receive Sipuleucel-T SO CANCER IMMUNOLOGY RESEARCH LA English DT Article ID ABSOLUTE LYMPHOCYTE COUNT; PROGNOSTIC-FACTOR; CLINICAL-TRIALS; IMPACT TRIAL; IMMUNOTHERAPY; DOCETAXEL; BENEFIT; ANTIGEN; LEUKAPHERESIS; MITOXANTRONE AB Sipuleucel-T is an autologous cellular immunotherapy used to treat asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Traditional short-term indicators of clinical response commonly used with chemotherapy have not correlated with survival in patients treated with sipuleucel-T. This retrospective study aimed to evaluate laboratory parameters as possible early biomarkers associated with clinical benefit following sipuleucel-T treatment. Patients treated with sipuleucel-T from three randomized, controlled, phase III clinical trials in mCRPC were considered: IMPACT (NCT00065442; n = 512), D9901 (NCT00005947; n = 127), and D9902A (NCT01133704; n = 98). Patients from these trials were included in this study if their samples were analyzed by the central laboratory and if data were available from baseline and >= 1 posttreatment time point (n = 377). We found that sipuleucel-T treatment was associated with a transient increase in serum eosinophil count at week 6 that resolved by week 14 in 28% of patients (105 of 377). This eosinophil increase correlated with induced immune response, longer prostate cancer-specific survival [HR, 0.713; 95% confidence interval (CI), 0.525-0.970; P = 0.031], and a trend in overall survival (HR, 0.753; 95% CI, 0.563-1.008; P = 0.057). Median serum globulin protein levels also increased transiently, which was associated with antigen-specific antibody responses; however, this finding did not correlate with longer survival. We conclude that transient increases in eosinophils at week 6 may be a useful, objective, short-term indicator of global immune activation and survival benefit with sipuleucel-T in patients with mCRPC. This observation warrants prospective evaluation in future clinical trials. (C) 2014 AACR. C1 [McNeel, Douglas G.] Univ Wisconsin, Carbone Canc Ctr, Dept Med, Madison, WI 53705 USA. [Gardner, Thomas A.] Indiana Univ, Simon Canc Ctr, Dept Urol, Indianapolis, IN 46204 USA. [Higano, Celestia S.] Univ Washington, Dept Med, Seattle, WA USA. [Higano, Celestia S.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Kantoff, Philip W.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Small, Eric J.] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco Comprehens Canc Ctr, San Francisco, CA 94143 USA. [Wener, Mark H.] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. [Sims, Robert B.; DeVries, Todd; Sheikh, Nadeem A.] Dendreon Corp, Seattle, WA USA. [Dreicer, Robert] Cleveland Clin, Taussig Canc Inst, Dept Solid Tumor Oncol, Cleveland, OH 44106 USA. RP McNeel, DG (reprint author), Univ Wisconsin, Ctr Comprehens Canc, Wisconsin Inst Med Res 7007, 1111 Highland Ave, Madison, WI 53705 USA. EM dm3@medicine.wisc.edu FU Dendreon Corporation FX This study was financially supported by Dendreon Corporation. NR 41 TC 9 Z9 9 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 2326-6066 EI 2326-6074 J9 CANCER IMMUNOL RES JI Cancer Immunol. Res. PD OCT PY 2014 VL 2 IS 10 BP 988 EP 999 DI 10.1158/2326-6066.CIR-14-0073 PG 12 WC Oncology; Immunology SC Oncology; Immunology GA AW2QR UT WOS:000346134100009 PM 25189164 ER PT J AU Bachhuber, MA Saloner, B Cunningham, CO Barry, CL AF Bachhuber, Marcus A. Saloner, Brendan Cunningham, Chinazo O. Barry, Colleen L. TI Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010 SO JAMA INTERNAL MEDICINE LA English DT Article ID CHRONIC NONCANCER PAIN; MARIJUANA USE; DRUG-USE; YOUNG-ADULTS; ABUSE; WITHDRAWAL; DEPENDENCE; PATTERNS; DEATHS; COHORT AB IMPORTANCE Opioid analgesic overdose mortality continues to rise in the United States, driven by increases in prescribing for chronic pain. Because chronic pain is a major indication for medical cannabis, laws that establish access to medical cannabis may change overdose mortality related to opioid analgesics in states that have enacted them. OBJECTIVE To determine the association between the presence of state medical cannabis laws and opioid analgesic overdose mortality. DESIGN, SETTING, AND PARTICIPANTS A time-series analysis was conducted of medical cannabis laws and state-level death certificate data in the United States from 1999 to 2010; all 50 states were included. EXPOSURES Presence of a law establishing a medical cannabis program in the state. MAIN OUTCOMES AND MEASURES Age-adjusted opioid analgesic overdose death rate per 100 000 population in each state. Regression models were developed including state and year fixed effects, the presence of 3 different policies regarding opioid analgesics, and the state-specific unemployment rate. RESULTS Three states (California, Oregon, and Washington) had medical cannabis laws effective prior to 1999. Ten states (Alaska, Colorado, Hawaii, Maine, Michigan, Montana, Nevada, New Mexico, Rhode Island, and Vermont) enacted medical cannabis laws between 1999 and 2010. States with medical cannabis laws had a 24.8% lower mean annual opioid overdose mortality rate (95% CI, -37.5% to -9.5%; P = .003) compared with states without medical cannabis laws. Examination of the association between medical cannabis laws and opioid analgesic overdose mortality in each year after implementation of the law showed that such laws were associated with a lower rate of overdose mortality that generally strengthened over time: year 1 (-19.9%; 95% CI, -30.6% to -7.7%; P = .002), year 2 (-25.2%; 95% CI, -40.6% to -5.9%; P = .01), year 3 (-23.6%; 95% CI, -41.1% to -1.0%; P = .04), year 4 (-20.2%; 95% CI, -33.6% to -4.0%; P = .02), year 5 (-33.7%; 95% CI, -50.9% to -10.4%; P = .008), and year 6 (-33.3%; 95% CI, -44.7% to -19.6%; P < .001). In secondary analyses, the findings remained similar. CONCLUSIONS AND RELEVANCE Medical cannabis laws are associated with significantly lower state-level opioid overdose mortality rates. Further investigation is required to determine how medical cannabis laws may interact with policies aimed at preventing opioid analgesic overdose. C1 [Bachhuber, Marcus A.] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA 19104 USA. [Bachhuber, Marcus A.] Univ Penn, Robert Wood Johnson Fdn Clin Scholars Program, Philadelphia, PA 19104 USA. [Bachhuber, Marcus A.; Saloner, Brendan; Barry, Colleen L.] Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA. [Saloner, Brendan] Univ Penn, Robert Wood Johnson Hlth & Soc Scholars Program, Philadelphia, PA 19104 USA. [Cunningham, Chinazo O.] Montefiore Med Ctr, Albert Einstein Coll Med, Div Gen Internal Med, Bronx, NY 10467 USA. [Barry, Colleen L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA. RP Bachhuber, MA (reprint author), Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, 423 Guardian Dr,1303-A Blockley Hall, Philadelphia, PA 19104 USA. EM marcus.bachhuber@gmail.com OI Bachhuber, Marcus/0000-0002-5610-8382 FU National Institutes of Health (NIH) [R01DA032110, R25DA023021]; Center for AIDS Research at the Albert Einstein College of Medicine; Montefiore Medical Center grant [NIH AI-51519]; Robert Wood Johnson Foundation Health and Society Scholars Program; Philadelphia Veterans Affairs Medical Center; Robert Wood Johnson Foundation Clinical Scholars Program FX This work was funded by National Institutes of Health (NIH) grants R01DA032110 and R25DA023021 and the Center for AIDS Research at the Albert Einstein College of Medicine and Montefiore Medical Center grant NIH AI-51519. Dr Saloner received funding support from the Robert Wood Johnson Foundation Health and Society Scholars Program. Dr Bachhuber received funding support from the Philadelphia Veterans Affairs Medical Center and the Robert Wood Johnson Foundation Clinical Scholars Program. NR 42 TC 64 Z9 65 U1 5 U2 38 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD OCT PY 2014 VL 174 IS 10 BP 1668 EP 1673 DI 10.1001/jamainternmed.2014.4005 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AU9JS UT WOS:000345909100029 PM 25154332 ER PT J AU Schopfer, DW Takemoto, S Allsup, K Helfrich, CD Ho, PM Forman, DE Whooley, MA AF Schopfer, David W. Takemoto, Steven Allsup, Kelly Helfrich, Christian D. Ho, P. Michael Forman, Daniel E. Whooley, Mary A. TI Cardiac Rehabilitation Use Among Veterans With Ischemic Heart Disease SO JAMA INTERNAL MEDICINE LA English DT Letter ID PERFORMANCE-MEASURES; ASSOCIATION; DELIVERY C1 [Schopfer, David W.; Takemoto, Steven; Whooley, Mary A.] San Francisco VA Med Ctr, Dept Med, San Francisco, CA 94121 USA. [Allsup, Kelly; Forman, Daniel E.] Vet Affairs Boston Healthcare Syst, New England Geriatr Res Educ & Clin Ctr, Boston, MA USA. [Helfrich, Christian D.] Vet Affairs Puget Sound Healthcare Syst, Northwest Hlth Serv Res & Dev Ctr Excellence, Seattle, WA USA. [Ho, P. Michael] Denver Vet Affairs Med Ctr, Div Cardiol, Denver, CO USA. [Ho, P. Michael] Univ Colorado, Div Cardiol, Dept Med, Hlth Sci Ctr, Denver, CO 80262 USA. [Forman, Daniel E.] Vet Affairs Boston Healthcare Syst, Div Cardiovasc Med, Boston, MA USA. [Forman, Daniel E.] Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA. [Forman, Daniel E.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Whooley, Mary A.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Whooley, Mary A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. RP Schopfer, DW (reprint author), San Francisco VA Med Ctr, 4150 Clement St 111A1, San Francisco, CA 94121 USA. EM david.schopfer@gmail.com RI Helfrich, Christian/D-2382-2016 OI Helfrich, Christian/0000-0002-9827-4768 NR 5 TC 3 Z9 3 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD OCT PY 2014 VL 174 IS 10 BP 1687 EP 1689 DI 10.1001/jamainternmed.2014.3441 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AU9JS UT WOS:000345909100033 PM 25133868 ER PT J AU Theisen-Toupal, J Horowitz, G Breu, A AF Theisen-Toupal, Jesse Horowitz, Gary Breu, Anthony TI Low Yield of Outpatient Serum Folate Testing: Eleven Years of Experience SO JAMA INTERNAL MEDICINE LA English DT Letter ID ANEMIA; UTILITY C1 [Theisen-Toupal, Jesse] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA. [Horowitz, Gary] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA. [Breu, Anthony] VA Boston Healthcare Syst, Med Serv, West Roxbury, MA USA. RP Theisen-Toupal, J (reprint author), Beth Israel Deaconess Med Ctr, 330 Brookline Ave,Span 2, Boston, MA 02215 USA. EM jtoupal@bidmc.harvard.edu NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD OCT PY 2014 VL 174 IS 10 BP 1696 EP 1697 DI 10.1001/jamainternmed.2014.3593 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AU9JS UT WOS:000345909100040 PM 25111789 ER PT J AU Schmajuk, G Bozic, KJ Yazdany, J AF Schmajuk, Gabriela Bozic, Kevin J. Yazdany, Jinoos TI Using Medicare Data to Understand Low-Value Health Care: The Case of Intra-articular Hyaluronic Acid Injections SO JAMA INTERNAL MEDICINE LA English DT Editorial Material C1 [Schmajuk, Gabriela; Yazdany, Jinoos] Univ Calif San Francisco, Dept Med & Rheumatol, San Francisco, CA 94143 USA. [Schmajuk, Gabriela] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Bozic, Kevin J.] Univ Calif San Francisco, Dept Orthoped Surg, San Francisco, CA 94143 USA. [Bozic, Kevin J.] Philip R Lee Inst Hlth Policy Studies, San Francisco, CA USA. RP Schmajuk, G (reprint author), San Francisco VA Med Ctr, Dept Med & Rheumatol, 4150 Clement St,Mail Stop 111R, San Francisco, CA 94121 USA. EM gabriela.schmajuk@ucsf.edu FU NIAMS NIH HHS [K23 AR060259, K23 AR063770] NR 7 TC 7 Z9 7 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD OCT PY 2014 VL 174 IS 10 BP 1702 EP 1704 DI 10.1001/jamainternmed.2014.3926 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AU9JS UT WOS:000345909100044 PM 25156406 ER PT J AU Motte, K Caldwell, CB Lamson, KS Ferimer, S Nims, JC AF Motte, Kristin Caldwell, C. Brooke Lamson, Karen S. Ferimer, Suzanne Nims, J. Chris CA Assoc Vision Sci Librarians TI Standards for vision science libraries: 2014 revision SO JOURNAL OF THE MEDICAL LIBRARY ASSOCIATION LA English DT Article AB Objective: This Association of Vision Science Librarians revision of the "Standards for Vision Science Libraries" aspires to provide benchmarks to address the needs for the services and resources of modern vision science libraries (academic, medical or hospital, pharmaceutical, and so on), which share a core mission, are varied by type, and are located throughout the world. Methods: Through multiple meeting discussions, member surveys, and a collaborative revision process, the standards have been updated for the first time in over a decade. Results: While the range of types of libraries supporting vision science services, education, and research is wide, all libraries, regardless of type, share core attributes, which the standards address. Conclusions: The current standards can and should be used to help develop new vision science libraries or to expand the growth of existing libraries, as well as to support vision science librarians in their work to better provide services and resources to their respective users. C1 [Motte, Kristin] New England Coll Optometry, Boston, MA 02115 USA. [Caldwell, C. Brooke] Southern Coll Optometry, Memphis, TN 38104 USA. [Lamson, Karen S.] Massachusetts Coll Pharm & Hlth Sci MCPHS Univ, Blais Family Lib, Worcester, MA 01608 USA. [Ferimer, Suzanne] Univ Houston, Weston A Pettey Lib, Houston, TX 77204 USA. [Nims, J. Chris] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA. RP Motte, K (reprint author), New England Coll Optometry, 424 Beacon St, Boston, MA 02115 USA. EM mottek@neco.edu; cbcaldwell@sco.edu; karen.lamson@mcphs.edu; SFerimer@optometry.uh.edu; Judith_nims@meei.harvard.edu NR 13 TC 0 Z9 0 U1 2 U2 8 PU MEDICAL LIBRARY ASSOC PI CHICAGO PA 65 EAST WACKER PLACE, STE 1900, CHICAGO, IL 60601-7298 USA SN 1536-5050 J9 J MED LIBR ASSOC JI J. Med. Libr. Assoc. PD OCT PY 2014 VL 102 IS 4 BP 288 EP 291 DI 10.3163/1536-5050.102.4.010 PG 4 WC Information Science & Library Science SC Information Science & Library Science GA AW2WB UT WOS:000346146200009 PM 25349547 ER PT J AU Lassen, KG Xavier, RJ AF Lassen, Kara G. Xavier, Ramnik J. TI An alteration in ATG16L1 stability in Crohn disease SO AUTOPHAGY LA English DT Editorial Material DE Crohn disease; ATG16L1; IL1B; antibacterial autophagy; caspase cleavage AB Individuals who harbor a common coding polymorphism (Thr300Ala) within a structurally unclassified region of ATG16L1 are at increased risk for the development of Crohn disease. Recently, we reported on the generation and characterization of knockin mice carrying the ATG16L1 T300A variant. We demonstrate that multiple cell types from T300A knock-in mice exhibit reduced selective autophagy, and we mechanistically link this phenotype with an increased susceptibility of ATG16L1 T300A to CASP3- and CASP7-mediated cleavage. These findings demonstrate how a single polymorphism can result in cell type-and pathway-specific disruptions of selective autophagy and alterations in the inflammatory milieu that can contribute to disease. C1 [Lassen, Kara G.; Xavier, Ramnik J.] Broad Inst, Cambridge, MA 02142 USA. [Lassen, Kara G.; Xavier, Ramnik J.] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA. [Xavier, Ramnik J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Gastrointestinal Unit, Boston, MA USA. [Xavier, Ramnik J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Study Inflammatory Bowel Dis, Boston, MA USA. RP Lassen, KG (reprint author), Broad Inst, Cambridge, MA 02142 USA. EM klassen@broadinstitute.org FU NIDDK NIH HHS [R01 DK097485] NR 0 TC 4 Z9 4 U1 0 U2 0 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8627 EI 1554-8635 J9 AUTOPHAGY JI Autophagy PD OCT PY 2014 VL 10 IS 10 BP 1858 EP 1860 DI 10.4161/auto.29963 PG 3 WC Cell Biology SC Cell Biology GA AU6HQ UT WOS:000345704900015 PM 25136803 ER PT J AU Wang, ZH Deisboeck, TS Cristini, V AF Wang, Zhihui Deisboeck, Thomas S. Cristini, Vittorio TI Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models SO IET SYSTEMS BIOLOGY LA English DT Article ID CELL LUNG-CANCER; EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR; CROSS-SCALE; IDENTIFICATION; UNCERTAINTY; PATHWAY; TIME AB There are two challenges that researchers face when performing global sensitivity analysis (GSA) on multiscale 'in silico' cancer models. The first is increased computational intensity, since a multiscale cancer model generally takes longer to run than does a scale-specific model. The second problem is the lack of a best GSA method that fits all types of models, which implies that multiple methods and their sequence need to be taken into account. In this study, the authors therefore propose a sampling-based GSA workflow consisting of three phases - pre-analysis, analysis and post-analysis - by integrating Monte Carlo and resampling methods with the repeated use of analysis of variance; they then exemplify this workflow using a two-dimensional multiscale lung cancer model. By accounting for all parameter rankings produced by multiple GSA methods, a summarised ranking is created at the end of the workflow based on the weighted mean of the rankings for each input parameter. For the cancer model investigated here, this analysis reveals that extracellular signal-regulated kinase, a downstream molecule of the epidermal growth factor receptor signalling pathway, has the most important impact on regulating both the tumour volume and expansion rate in the algorithm used. C1 [Wang, Zhihui; Cristini, Vittorio] Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA. [Deisboeck, Thomas S.] Massachusetts Gen Hosp, Harvard HST Athinoula Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA 02129 USA. [Cristini, Vittorio] Univ New Mexico, Dept Chem Engn, Albuquerque, NM 87131 USA. [Cristini, Vittorio] Univ New Mexico, Ctr Biomed Engn, Albuquerque, NM 87131 USA. [Cristini, Vittorio] King Abdulaziz Univ, Dept Math, Fac Sci, Jeddah 21589, Saudi Arabia. RP Wang, ZH (reprint author), ThinkMotu LLC, Wellesley, MA 02481 USA. EM ZWang@salud.unm.edu RI Cristini, Vittorio/N-3540-2013 FU National Science Foundation (NSF) [DMS-1263742]; NSF SBIR [1315372]; National Institutes of Health (NIH) [1U54CA149196, 1U54CA143837, 1U54CA151668, 1U54CA143907]; University of New Mexico Cancer Center Victor and Ruby Hansen Surface Professorship in Molecular Modeling of Cancer; Methodist Hospital Research Institute; Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging; Department of Radiology at Massachusetts General Hospital FX This work has been supported in part by the National Science Foundation (NSF) Grant DMS-1263742 (Z.W., V.C.), NSF SBIR 1315372, the National Institutes of Health (NIH) Grant 1U54CA149196, 1U54CA143837, 1U54CA151668, and 1U54CA143907 (V.C.), the University of New Mexico Cancer Center Victor and Ruby Hansen Surface Professorship in Molecular Modeling of Cancer (V.C.), the Methodist Hospital Research Institute (V.C.), and the Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging and the Department of Radiology at Massachusetts General Hospital (T.S.D.). NR 32 TC 3 Z9 3 U1 0 U2 7 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8849 EI 1751-8857 J9 IET SYST BIOL JI IET Syst. Biol. PD OCT PY 2014 VL 8 IS 5 BP 191 EP 197 DI 10.1049/iet-syb.2013.0026 PG 7 WC Cell Biology; Mathematical & Computational Biology SC Cell Biology; Mathematical & Computational Biology GA AU6JJ UT WOS:000345709300001 PM 25257020 ER PT J AU Wei, Y Yung, LM Qin, T Barfejani, AH Waeber, C AF Wei, Y. Yung, L. M. Qin, T. Barfejani, A. H. Waeber, C. TI delayed treatment with fingolimod (fty720) improves long-term recovery after stroke SO INTERNATIONAL JOURNAL OF STROKE LA English DT Meeting Abstract C1 [Wei, Y.; Yung, L. M.; Qin, T.; Barfejani, A. H.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA USA. [Waeber, C.] Natl Univ Ireland Univ Coll Cork, Dept Pharmacol, Sch Pharm, Cork, Ireland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1747-4930 EI 1747-4949 J9 INT J STROKE JI Int. J. Stroke PD OCT PY 2014 VL 9 SU 3 SI SI MA WSC-1513 BP 37 EP 37 PG 1 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AU7GB UT WOS:000345767700102 ER PT J AU Rost, NS Giugliano, RP Ruff, CT Murphy, SA Crompton, AE Mercuri, M Antman, EM Braunwald, EM AF Rost, N. S. Giugliano, R. P. Ruff, C. T. Murphy, S. A. Crompton, A. E. Mercuri, M. Antman, E. M. Braunwald, E. M. TI Efficacy and safety of edoxaban vs. warfarin in high-risk patients: The ENGAGE AF-TIMI 48 trial SO INTERNATIONAL JOURNAL OF STROKE LA English DT Meeting Abstract C1 [Rost, N. S.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Giugliano, R. P.; Ruff, C. T.; Murphy, S. A.; Crompton, A. E.; Antman, E. M.; Braunwald, E. M.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Mercuri, M.] Daiichi Sankyo Pharma Dev, Clin Dev, Edison, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1747-4930 EI 1747-4949 J9 INT J STROKE JI Int. J. Stroke PD OCT PY 2014 VL 9 SU 3 SI SI MA WSC-1119 BP 38 EP 39 PG 2 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AU7GB UT WOS:000345767700105 ER PT J AU Lanthier, S Ferro, JM Calabrese, LH Strbian, D Putaala, J Singhal, AB Salvarani, C Letourneau-Guillon, L Frosch, MP Chagnon, M Guilbert, F Raymond, J AF Lanthier, S. Ferro, J. M. Calabrese, L. H. Strbian, D. Putaala, J. Singhal, A. B. Salvarani, C. Letourneau-Guillon, L. Frosch, M. P. Chagnon, M. Guilbert, F. Raymond, J. TI The International Study on Primary Angiitis of the Central Nervous System (INTERSPACE) - More study sites are needed! SO INTERNATIONAL JOURNAL OF STROKE LA English DT Meeting Abstract C1 [Lanthier, S.] Univ Montreal, Dept Neurosci, Montreal, PQ, Canada. [Ferro, J. M.] Univ Lisbon, Hosp Santa Maria, Dept Neurol, P-1699 Lisbon, Portugal. [Calabrese, L. H.] Cleveland Clin, Dept Rheumat & Immunol Dis, Cleveland, OH 44106 USA. [Strbian, D.; Putaala, J.] Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland. [Singhal, A. B.] Massachusetts Gen Hosp, Div Neurol, Boston, MA 02114 USA. [Salvarani, C.] Azienda Osped ASMN Ist Ricovero & Cura Carattere, Div Rheumatol, Reggio Emilia, Italy. [Letourneau-Guillon, L.; Guilbert, F.; Raymond, J.] Univ Montreal, Dept Radiol, Montreal, PQ, Canada. [Frosch, M. P.] Massachusetts Gen Hosp, Kubik Lab Neuropathol, Boston, MA 02114 USA. [Chagnon, M.] Univ Montreal, Dept Math & Stat, Montreal, PQ H3C 3J7, Canada. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1747-4930 EI 1747-4949 J9 INT J STROKE JI Int. J. Stroke PD OCT PY 2014 VL 9 SU 3 SI SI MA WSC-1449 BP 251 EP 252 PG 2 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AU7GB UT WOS:000345767700721 ER PT J AU Santucci, AK Singer, LT Wisniewski, SR Luther, JF Eng, HF Dills, JL Sit, DKY Hanusa, BH Wisner, KL AF Santucci, Aimee K. Singer, Lynn T. Wisniewski, Stephen R. Luther, James F. Eng, Heather F. Dills, John L. Sit, Dorothy K. Y. Hanusa, Barbara H. Wisner, Katherine L. TI Impact of Prenatal Exposure to Serotonin Reuptake Inhibitors or Maternal Major Depressive Disorder on Infant Developmental Outcomes SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID ANTIDEPRESSANT DRUGS; SSRI ANTIDEPRESSANTS; ANTENATAL ANXIETY; FOLLOW-UP; IN-UTERO; PREGNANCY; CHILDREN; BEHAVIORS; NEWBORN; HEALTH AB Objective: To examine the impact of prenatal exposure to both serotonin reuptake inhibitors (SRIs; during any trimester) and maternal major depressive disorder (MDD; by DSM-IV criteria) on infant functioning. We hypothesized that infants with prenatal exposure to SRIs or MDD would have lower psychomotor, mental, and behavioral scores compared with nonexposed infants. Method: This longitudinal study included 166 mother-infant dyads: 68 with prenatal MDD/SRI (n = 41) or MDD/no SRI exposure (n = 27) and 98 nonexposed controls. Maternal depression and SRI exposure assessments were completed at or as near to 20, 30, and 36 prenatal weeks and 12, 26, 52, and 78 weeks postpartum as feasible. Infants were evaluated with the Bayley Scales of Infant Development, Second Edition, including the psychomotor (Psychomotor Development Index; PDI), cognitive (Mental Development Index; MDI), and behavioral (Behavioral Rating Scale; BRS) components. Study assessments occurred between 2003 and 2009. Results: Neither prenatal exposure to MDD/SRI nor MDD/no SRI significantly impacted overall PDI, MDI, or BRS scores. However, we observed a significant SRI exposure by time interaction for the PDI (P = .038). MDD/SRI exposure was associated with lower PDI scores at 26 (mean = 97.0) and 52 weeks (mean = 92.9) compared with nonexposed infants (mean = 101.4 and 100.5). This difference was no longer significant at the 78-week assessment. Conclusions: Consistent with previous studies, we found no impact of prenatal MDD/SRI exposure on MDI scores. Less favorable PDI scores were observed in the first year; notably, these scores remained well within the normative range. The effects of prenatal MDD/SRI exposure on motor functioning may be transitory. A longitudinal pattern of poor developmental outcomes has not been established. (C) Copyright 2014 Physicians Postgraduate Press, Inc. C1 [Santucci, Aimee K.] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, Memphis, TN 38105 USA. [Singer, Lynn T.] Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA. [Singer, Lynn T.] Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44106 USA. [Singer, Lynn T.] Case Western Reserve Univ, Dept Psychol, Cleveland, OH 44106 USA. [Singer, Lynn T.] Case Western Reserve Univ, Dept Environm Hlth Sci, Cleveland, OH 44106 USA. [Wisniewski, Stephen R.; Luther, James F.; Dills, John L.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA. [Sit, Dorothy K. Y.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA. [Hanusa, Barbara H.] VA Pittsburgh Healthcare Syst, CHERP, Pittsburgh, PA USA. [Hanusa, Barbara H.] VA Pittsburgh Healthcare Syst, MIRECC, Pittsburgh, PA USA. [Wisner, Katherine L.] Northwestern Univ, Asher Ctr Study & Treatment Depress Disorders, Chicago, IL 60611 USA. [Wisner, Katherine L.] Northwestern Univ, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA. [Wisner, Katherine L.] Northwestern Univ, Dept Obstet & Gynecol, Chicago, IL 60611 USA. RP Santucci, AK (reprint author), St Jude Childrens Res Hosp, 262 Danny Thomas Pl,Mail Stop 735, Memphis, TN 38105 USA. EM aimee.santucci@stjude.org OI Wisniewski, Stephen/0000-0002-3877-9860 FU National Institute of Mental Health [5R01 MH60335, 5K23MH082114-05]; Clinical Research Training Program at Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania - National Institute of Mental Health [T32 MH16804-22] FX This research was supported by National Institute of Mental Health grant 5R01 MH60335 (Project investigator: Dr Wisner). The corresponding author (Dr Santucci) was supported by the Clinical Research Training Program (T32 MH16804-22) at Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, funded by National Institute of Mental Health while this research was conducted. Dr Sit was supported by 5K23MH082114-05 (Project investigator: Dr Sit) funded by National Institute of Mental Health. This work was conducted within Women's Behavioral HealthCARE, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Drs Santucci, Hanusa, and Wisner have relocated. NR 40 TC 10 Z9 10 U1 1 U2 7 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD OCT PY 2014 VL 75 IS 10 BP 1088 EP 1095 DI 10.4088/JCP.13m08902 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AU4CT UT WOS:000345557300024 PM 25373117 ER PT J AU Goodman, JH Chenausky, KL Freeman, MP AF Goodman, Janice H. Chenausky, Kerry L. Freeman, Marlene P. TI Anxiety Disorders During Pregnancy: A Systematic Review SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Review ID OBSESSIVE-COMPULSIVE DISORDER; POSTTRAUMATIC-STRESS-DISORDER; QUALITY-OF-LIFE; PERINATAL DEPRESSION-RESEARCH; UNIT PND-RESCU; PANIC DISORDER; POSTPARTUM DEPRESSION; RISK-FACTORS; PSYCHIATRIC-DISORDERS; MATERNAL ANXIETY AB Objective: To systematically evaluate the literature on anxiety disorders during pregnancy. Data Sources: MEDLINE, PsycINFO, and CINAHL were searched through October 2013 for original research studies published in English using combinations of the terms pregnancy, prenatal, or pregnancy outcomes; anxiety disorder; and generalized anxiety. Reference lists of included studies were hand-searched and a PubMed search for in-process reports was conducted. Study Selection: Relevant studies of anxiety disorders during pregnancy as determined by diagnostic interview were included if they reported on prevalence; course, onset, and/or risk factors; maternal, obstetric, or fetal/child outcomes; and/or treatment trial results. Data Extraction: Two reviewers independently extracted relevant data and assessed methodological quality of each study. Results: Fifty-seven reports were included. Reports provided information on panic disorder (25 reports), generalized anxiety disorder (17 reports), obsessive-compulsive disorder (OCD) (23 reports), agoraphobia (6 reports), specific phobia (10 reports), social phobia (14 reports), posttraumatic stress disorder (14 reports), and any anxiety disorder (18 reports). Twenty reports provided information on prevalence, 16 on course, 10 on risk factors, and 22 on outcomes. Only 1 treatment study was identified. High anxiety disorder prevalence in pregnancy was found; however, estimates vary considerably, and evidence is inconclusive as to whether prevalence among pregnant women differs from that of nonpregnant populations. Considerable variation in prenatal course of OCD and panic disorder was found. Substantial heterogeneity limits conclusions regarding risk factors or outcomes. Conclusions: Additional research of higher methodological quality is required to more accurately determine prevalence, understand course, identify risk factors and outcomes, and determine effective treatments for anxiety disorders in pregnancy. (C) Copyright 2014 Physicians Postgraduate Press, Inc. C1 [Goodman, Janice H.; Chenausky, Kerry L.] Sch Nursing, MGH Inst Hlth Profess, Boston, MA USA. [Freeman, Marlene P.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Freeman, Marlene P.] Massachusetts Gen Hosp, Perinatal & Reprod Psychiat Program, Boston, MA 02114 USA. [Chenausky, Kerry L.] Fifth Ave Fertil, New York, NY USA. RP Goodman, JH (reprint author), Sch Nursing, Inst Hlth Profess, 36 1st Ave, Boston, MA 02129 USA. EM jgoodman@mghihp.edu FU GlaxoSmithKline FX Dr Freeman has received research support from GlaxoSmithKline; has served on advisory boards for Takeda/Lundbeck, Otsuka, Genentech, and Johnson and Johnson; has served as consultant for JDS Therapeutics and Relizen; and has performed medical editing for DSM nutritionals. Dr Goodman and Ms Chenausky have no potential conflicts of interest. NR 110 TC 21 Z9 21 U1 3 U2 46 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD OCT PY 2014 VL 75 IS 10 BP E1153 EP + DI 10.4088/JCP.14r09035 PG 38 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AU4CT UT WOS:000345557300008 PM 25373126 ER PT J AU Klingensmith, K Tsai, J Mota, N Southwick, SM Pietrzak, RH AF Klingensmith, Katherine Tsai, Jack Mota, Natalie Southwick, Steven M. Pietrzak, Robert H. TI Military Sexual Trauma in US Veterans: Results From the National Health and Resilience in Veterans Study SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; POSTTRAUMATIC-STRESS-DISORDER; WOMEN VETERANS; DSM-IV; ASSAULT; PREVALENCE; PTSD; QUESTIONNAIRE; VALIDATION; SYMPTOMATOLOGY AB Objective: To evaluate the prevalence of military sexual trauma (MST) among US veterans, identify sociodemographic and military characteristics of MST, and examine the relationships between MST and psychiatric comorbidities, functioning/quality of life, and mental health treatment utilization. Method: Data were analyzed from the National Health and Resilience in Veterans Study, a contemporary, nationally representative survey of 1,484 US veterans conducted September-October 2013. Poststratification weights were applied to analyses to permit generalizability of results to the US veteran population. Outcomes measured include history of MST, trauma histories, lifetime and current DSM-IV mental disorders, functioning and quality of life, and utilization of mental health treatment. Results: The overall prevalence of MST was 7.6% and was higher among female than male veterans (32.4% vs 4.8%) and younger than older veterans (22.8% among veterans aged 18-29 years vs 4.5% among veterans aged 60+ years). After adjustment for sociodemographic and military characteristics, MST was associated with elevated rates of current major depressive disorder, posttraumatic stress disorder, and generalized anxiety disorder (adjusted odds ratio [aOR] range, 2.19-3.12); past history of suicide attempt (aOR - 2.78) and current suicidal ideation (aOR = 2.19); and decreased mental and cognitive functioning and quality of life (Cohen d, 0.23-0.38). MST was also associated with increased current utilization of psychotropic medication (aOR = 3.70) and psychotherapy or counseling (aOR = 2.41), independent of psychiatric morbidities. Conclusions: 7.6% of US veterans screen positive for MST, with substantially higher rates among female and younger veterans. MST is associated with elevated rates of several psychiatric morbidities and suicidality, reduced functioning and quality of life, and increased mental health treatment utilization, independent of other sociodemographic, military, and mental health factors. These results suggest that MST is prevalent among US veterans and associated with elevated health burden. Findings can help inform efforts to identify at-risk veterans and characterize the concomitant health burden and needs associated with MST in this population. (C) Copyright 2014 Physicians Postgraduate Press, Inc. C1 [Klingensmith, Katherine; Tsai, Jack; Southwick, Steven M.; Pietrzak, Robert H.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Tsai, Jack] US Dept Vet Affairs, New England Mental Illness Res Educ & Clin Ctr, West Haven, CT USA. [Mota, Natalie] Univ Manitoba, Dept Psychol, Winnipeg, MB R3T 2N2, Canada. [Southwick, Steven M.; Pietrzak, Robert H.] US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, Clin Neurosci Div, West Haven, CT USA. RP Pietrzak, RH (reprint author), Yale Univ, US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, Sch Med,Dept Psychiat,VA Connecticut Healthcare S, 950 Campbell Ave 151E, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu FU US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder FX This study was supported by the US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder and a private donation. NR 41 TC 12 Z9 12 U1 3 U2 26 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD OCT PY 2014 VL 75 IS 10 BP E1133 EP E1139 DI 10.4088/JCP.14m09244 PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AU4CT UT WOS:000345557300005 PM 25373123 ER PT J AU Suri, R Lin, AS Cohen, LS Altshuler, LL AF Suri, Rita Lin, Alex S. Cohen, Lee S. Altshuler, Lori L. TI Acute and Long-Term Behavioral Outcome of Infants and Children Exposed in Utero to Either Maternal Depression or Antidepressants: A Review of the Literature SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Review ID SEROTONIN REUPTAKE INHIBITORS; AMERICAN PSYCHIATRIC ASSOCIATION; NEONATAL ABSTINENCE SYNDROME; PRENATAL EXPOSURE; TRICYCLIC ANTIDEPRESSANTS; SSRI ANTIDEPRESSANTS; PLACENTAL PASSAGE; ASSESSMENT CAPA; PREGNANT-WOMEN; SYMPTOMS AB Objective: The authors reviewed the published literature on the acute and long-term neurobehavioral effects on infants and children of either in utero exposure to maternal depression or in utero exposure to antidepressants. Data Sources: The PubMed electronic database was searched to locate 292 English-language studies from the first available year to October 2013 using the keywords pregnancy, antidepressants, depression, perinatal, and neurobehavioral. Study Selection: The authors reviewed only prospective studies that assessed the impact of maternal depression during pregnancy or maternal antidepressant treatment during pregnancy on (1) clearly defined short-term behavioral outcomes in infants (perinatal outcome) or (2) longer-term behavioral outcomes in infants and children (neurodevelopmental outcome). Data Extraction: Studies were included if they were prospective and assessed the impact of maternal depression or maternal antidepressant treatment during pregnancy on clearly measurable, objective short-term and longer-term behavioral outcomes in infants and children. Results: Untreated depression during pregnancy is associated with short-term neonatal effects, including increased distress after delivery, less than optimal orientation and motor activity, and disrupted sleep. Longer-term effects on neurobehavioral outcome have also been reported, including disruptive social behavior, depression, and changes in the period of sensitivity for language discrimination. Antidepressant exposure during pregnancy is associated with adverse short-term perinatal symptomatology, including effects on autonomic and motor activity, habituation, and sleep. Longer-term studies of neurobehavioral outcomes of in utero antidepressant exposure suggest potential effects on gross motor function and language development but not cognition. Conclusions: In utero exposure to either maternal depression or antidepressants carries risks to the developing fetus. Treatment decisions regarding whether and how to treat depression during pregnancy must be made on an individual basis, with careful consideration of the impact of these decisions on both mother and infant. (C) Copyright 2014 Physicians Postgraduate Press, Inc. C1 [Suri, Rita; Lin, Alex S.; Altshuler, Lori L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Cohen, Lee S.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA USA. RP Suri, R (reprint author), UCLA Mood Disorders Res Program, 300 Med Plaza,Ste 1544, Los Angeles, CA 90095 USA. EM rsuri03@gmail.com FU Astra-Zeneca Pharmaceuticals; Bristol-Myers Squibb; Cephalon, Inc; GlaxoSmithKline; National Institute on Aging; National Institute of Mental Health; Ortho-McNeil Janssen; Sunovion Pharmaceuticals, Inc. FX In the past 12 months, Dr Cohen has served as a consultant to and advisory board member for Noven Pharmaceuticals and has received research support from Astra-Zeneca Pharmaceuticals; Bristol-Myers Squibb; Cephalon, Inc; GlaxoSmithKline; National Institute on Aging; National Institute of Mental Health; Ortho-McNeil Janssen; and Sunovion Pharmaceuticals, Inc. Dr Altshuler has served as an advisory board member for Sunovion Pharmaceuticals, Inc. Drs Suri and Lin report no financial or other relationship relevant to the subject of this article in the past 12 months. None of the above affiliations should result in a conflict of interest related to the subject of this article. NR 65 TC 15 Z9 15 U1 5 U2 25 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD OCT PY 2014 VL 75 IS 10 BP E1142 EP E1152 DI 10.4088/JCP.13r08926 PG 11 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AU4CT UT WOS:000345557300007 PM 25373125 ER PT J AU Ovbiagele, B Schwamm, LH Smith, EE Grau-Sepulveda, MV Saver, JL Bhatt, DL Hernandez, AF Peterson, ED Fonarow, GC AF Ovbiagele, Bruce Schwamm, Lee H. Smith, Eric E. Grau-Sepulveda, Maria V. Saver, Jeffrey L. Bhatt, Deepak L. Hernandez, Adrian F. Peterson, Eric D. Fonarow, Gregg C. TI Hospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES LA English DT Article DE Chronic kidney disease; outcomes; hemorrhagic strokerenal; quality indicators; prognosis; guidelines; glomerular filtration rate ID CHRONIC KIDNEY-DISEASE; TRANSIENT ISCHEMIC ATTACK; QUALITY-OF-CARE; INTRACEREBRAL HEMORRHAGE; CEREBRAL MICROBLEEDS; ASSOCIATION; GUIDELINES; RISK; PROFESSIONALS; MANAGEMENT AB Background: There is a paucity of information on clinical characteristics, care patterns, and clinical outcomes for hospitalized intracerebral hemorrhage (ICH) patients with chronic kidney disease (CKD). We assessed characteristics, care processes, and in-hospital outcome among ICH patients with CKD in the Get With the Guidelines-Stroke (GWTG-Stroke) program. Methods: We analyzed 113,059 ICH patients hospitalized at 1472 US centers participating in the GWTG-Stroke program between January 2009 and December 2012. In-hospital mortality and use of 2 predefined ICH performance measures were examined based on glomerular filtration rate. Renal dysfunction was categorized as a dichotomous (+CKD = estimated glomerular filtration rate,60) or rank ordered variable as CKD (<60), and by clinical stage: (normal [>= 90], mild [>= 60-<90], moderate [>= 30-<60], severe [>= 15-<30], and/or kidney failure [<15 or dialysis]). Results: There were 33,219 (29%) ICH patients with CKD. Patients with CKD were more likely to be older, female, and with comorbid conditions such as diabetes. Compared with patients with normal kidney function, those with CKD were slightly less likely to receive deep venous thrombosis (DVT) prophylaxis but similarly received discharge smoking cessation intervention. Inpatient mortality was also higher for those with CKD (adjusted odds ratio [OR], 1.47; 95% confidence interval [CI], 1.42-1.52), mild dysfunction (adjusted OR, 1.12; 95% CI, 1.08-1.16), moderate dysfunction (adjusted OR, 1.46; 95% CI, 1.39-1.53), severe dysfunction (adjusted OR, 1.96; 95% CI, 1.81-2.12), and kidney failure (adjusted OR, 2.22; 95% CI, 2.04-2.43) relative to those with normal renal function. Conclusions: Chronic kidney disease is present in nearly a third of patients hospitalized with ICH and is associated with slightly worse care and substantially higher mortality than those with normal renal function. C1 [Ovbiagele, Bruce] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA. [Schwamm, Lee H.] Massachusetts Gen Hosp, Div Neurol, Boston, MA 02114 USA. [Smith, Eric E.] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada. [Smith, Eric E.] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada. [Grau-Sepulveda, Maria V.; Hernandez, Adrian F.; Peterson, Eric D.] Duke Clin Res Inst, Outcomes Res & Assessment Grp, Durham, NC USA. [Saver, Jeffrey L.] Univ Calif Los Angeles, Stroke Ctr, Los Angeles, CA USA. [Saver, Jeffrey L.] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA USA. [Bhatt, Deepak L.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Bhatt, Deepak L.] Harvard Univ, Sch Med, Boston, MA USA. [Fonarow, Gregg C.] Univ Calif Los Angeles, Div Cardiol, Los Angeles, CA USA. RP Ovbiagele, B (reprint author), Med Univ S Carolina, Dept Neurosci, 96 Jonathan Lucas St,CSB 301,MSC 606, Charleston, SC 29425 USA. EM ovibes@musc.edu RI Hernandez, Adrian F./A-7818-2016; OI Saver, Jeffrey/0000-0001-9141-2251; Schwamm, Lee/0000-0003-0592-9145; Hernandez, Adrian F./0000-0003-3387-9616; Smith, Eric/0000-0003-3956-1668 FU American Heart Association; American Stroke Association; American Heart Association by Pfizer (New York, NY); Merck-Schering Plough Partnership (North Wales, PA) FX The Get With the Guidelines Program (GWTG) is funded by the American Heart Association and the American Stroke Association. The program is also supported in part by unrestricted educational grants to the American Heart Association by Pfizer (New York, NY) and the Merck-Schering Plough Partnership (North Wales, PA), who did not participate in the design, analysis, or article preparation, and did not require approval of this article for submission. NR 21 TC 4 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1052-3057 EI 1532-8511 J9 J STROKE CEREBROVASC JI J. Stroke Cerebrovasc. Dis. PD OCT PY 2014 VL 23 IS 9 BP 2265 EP 2273 DI 10.1016/j.jstrokecerebrovasdis.2014.04.016 PG 9 WC Neurosciences; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA AU5MA UT WOS:000345649900012 PM 25158677 ER PT J AU Levine, DA Walter, JM AF Levine, Deborah A. Walter, James M. TI Response to "Index Event Bias: Problems with Eliminating the Paradox" SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES LA English DT Letter C1 [Levine, Deborah A.] Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA. [Levine, Deborah A.] VA Ann Arbor Healthcare Syst, Ann Arbor, MI 48105 USA. [Walter, James M.] Univ Calif San Francisco, Dept Internal Med, San Francisco, CA 94143 USA. [Walter, James M.] San Francisco VA Med Ctr, San Francisco, CA 94143 USA. RP Levine, DA (reprint author), Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA. EM s.sep@mumc.nl NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1052-3057 EI 1532-8511 J9 J STROKE CEREBROVASC JI J. Stroke Cerebrovasc. Dis. PD OCT PY 2014 VL 23 IS 9 BP 2464 EP 2465 DI 10.1016/j.jstrokecerebrovasdis.2014.06.028 PG 3 WC Neurosciences; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA AU5MA UT WOS:000345649900041 PM 25194741 ER PT J AU Bickart, KC Dickerson, BC Barrett, LF AF Bickart, Kevin C. Dickerson, Bradford C. Barrett, Lisa Feldman TI The amygdala as a hub in brain networks that support social life SO NEUROPSYCHOLOGIA LA English DT Review DE Amygdala; Networks; Social life; Social brain; Social network ID MEDIAL PREFRONTAL NETWORKS; VARIANT FRONTOTEMPORAL DEMENTIA; INTRINSIC FUNCTIONAL CONNECTIVITY; IMPAIRED AFFECTIVE THEORY; CORTICAL AREAS TE; MACAQUE MONKEYS; NEURAL RESPONSES; INDIVIDUAL-DIFFERENCES; FACIAL EXPRESSIONS; DECISION-MAKING AB A growing body of evidence suggests that the amygdala is central to handling the demands of complex social life in primates. In this paper, we synthesize extant anatomical and functional data from rodents, monkeys, and humans to describe the topography of three partially distinct large-scale brain networks anchored in the amygdala that each support unique functions for effectively managing social interactions and maintaining social relationships. These findings provide a powerful componential framework for parsing social behavior into partially distinct neural underpinnings that differ among healthy people and disintegrate or fail to develop in neuropsychiatric populations marked by social impairment, such as autism, antisocial personality disorder, and frontotemporal dementia. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Bickart, Kevin C.] Northeastern Univ, Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02115 USA. [Dickerson, Bradford C.; Barrett, Lisa Feldman] Northeastern Univ, Psychiat Neuroimaging Res Program, Boston, MA 02115 USA. [Dickerson, Bradford C.; Barrett, Lisa Feldman] Northeastern Univ, Martinos Ctr Biomed Imaging, Boston, MA 02115 USA. [Dickerson, Bradford C.] Massachusetts Gen Hosp, Dept Neurol, Frontotemporal Disorders Unit, Boston, MA 02114 USA. [Dickerson, Bradford C.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. [Barrett, Lisa Feldman] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA. RP Barrett, LF (reprint author), Northeastern Univ, Dept Psychol, 125 Nightingale Hall, Boston, MA 02115 USA. EM l.barrett@neu.edu FU [R21-MH097094]; [R21-NS084156] FX The authors gratefully acknowledge patients and families who have participated in research, and funding sources including R21-MH097094 and R21-NS084156. NR 215 TC 23 Z9 24 U1 12 U2 37 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0028-3932 EI 1873-3514 J9 NEUROPSYCHOLOGIA JI Neuropsychologia PD OCT PY 2014 VL 63 BP 235 EP 248 DI 10.1016/j.neuropsychologia.2014.08.013 PG 14 WC Behavioral Sciences; Neurosciences; Psychology, Experimental SC Behavioral Sciences; Neurosciences & Neurology; Psychology GA AU7ZQ UT WOS:000345817100026 PM 25152530 ER PT J AU Hunt, KJ Kistner-Griffin, E Spruill, I Teklehaimanot, AA Garvey, WT Sale, M Fernandes, J AF Hunt, Kelly J. Kistner-Griffin, Emily Spruill, Ida Teklehaimanot, Abeba A. Garvey, W. Timothy Sale, Michele Fernandes, Jyotika TI Cardiovascular Risk in Gullah African Americans with High Familial Risk of Type 2 Diabetes Mellitus: Project SuGAR SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE African Americans; community-based participatory research; diabetes complications; public health; secondary prevention ID NUCLEAR-MAGNETIC-RESONANCE; CORONARY-ARTERY-DISEASE; DENSITY-LIPOPROTEIN PARTICLES; NUTRITION EXAMINATION SURVEY; IMPAIRED GLUCOSE-TOLERANCE; INSULIN-RESISTANCE; METABOLIC SYNDROME; ATHEROSCLEROSIS RISK; UNITED-STATES; NATIONAL-HEALTH AB Objectives: To determine the prevalence of cardiovascular disease, levels of cardiovascular risk factors, and extent of preventive care in Gullah African Americans with a high familial risk of type 2 diabetes mellitus. Methods: Between 1995 and 2003, 1321 Gullah African Americans with a high prevalence of diabetes mellitus from the South Carolina Sea Islands consented to and enrolled in the Sea Islands Genetic African American Registry (Project SuGAR). A cross-sectional analysis of cardiometabolic risk, preventive care, and self-reported cardiovascular disease was conducted. Results: Cardiometabolic risk factor levels were high and vascular disease was prevalent. Among the subjects with diabetes mellitus, the mean disease duration was 10.5 years; approximately one-third reported reduced vision or blindness; and >80% reported numbness, pain, or burning in their feet. Preventive diabetes carewas limited, with <60%, <25%, and <40% seeing an ophthalmologist, podiatrist, and dentist, respectively, within the past year. Only 54.4% of women and 39.3% of men reported daily glucose monitoring. Conclusions: As the largest existing study of Gullah individuals, our study offers insight into not only the level of cardiovascular risk in this population but also the pathophysiological mechanisms central to ancestral differences in cardiometabolic risk in the broader African American population. C1 [Hunt, Kelly J.] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA. Med Univ S Carolina, Coll Nursing, Charleston, SC 29425 USA. Ralph H Johnson Dept Vet Affairs Med Ctr, Hlth Equ & Rural Outreach Innovat Ctr, Charleston, SC 29401 USA. Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35233 USA. Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22903 USA. RP Hunt, KJ (reprint author), Med Univ S Carolina, Dept Publ Hlth Sci, 135 Cannon St,Suite 302,POB 25 0835, Charleston, SC 29425 USA. EM huntke@musc.edu FU Sea Islands Genetics Network [R01 DK084350]; National Institute on Minority Health and Health Disparities [R01-MD004251]; South Carolina Center of Biomedical Research Excellence in Oral Health [P20 RR017696]; National Institutes of Health; Department of Veterans Affairs; National Institute of Diabetes and Digestive and Kidney Diseases; Merck; AstraZeneca; Weight Watchers FX The project was supported by the Sea Islands Genetics Network R01 DK084350 (M.S.); a grant from the National Institute on Minority Health and Health Disparities (R01-MD004251); a South Carolina Center of Biomedical Research Excellence in Oral Health Project P20 RR017696 (J.F., subaward); and the study from which the data originated, Project SuGAR (W.T.G., Sea Islands Genetic African American Registry, W.M. Keck Foundation and American Diabetes Association).; K.J.H. has received grants from the National Institutes of Health and the Department of Veterans Affairs. E.K.G. has received grants from the National Institutes of Health. A.A.T. has received grants from the National Institutes of Health. I.S. has received a grant from the National Institute of Diabetes and Digestive and Kidney Diseases. W.T.G. has been a consultant to Daiichi-Sankyo, Liposcience, Eisai, Vivus, Novo Nordisk, Janssen, Bristol-Myers Squibb, AstraZeneca, Takeda Pharmaceuticals, and Boehringer-Ingelheim; he has provided expert testimony to the Federal Trade Commission; he has grants or grants pending from Merck, AstraZeneca, and Weight Watchers; he has served on the speakers' bureaus of Merck and Eisai; he has developed educational presentations for Pri-Med, CME Incite, and Vindico. M.S. and J.F. have no financial relationships to disclose and no conflicts of interest to report. NR 52 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD OCT PY 2014 VL 107 IS 10 BP 607 EP 614 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AU6WZ UT WOS:000345743400002 PM 25279862 ER PT J AU Kopacz, MS McCarten, JM Pollitt, MJ AF Kopacz, Marek S. McCarten, Janet M. Pollitt, Michael J. TI VHA Chaplaincy Contact with Veterans at Increased Risk of Suicide SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE chaplains; military veterans; suicide ID HELP-SEEKING; CARE; MORTALITY; SERVICES; PTSD AB Objectives: To examine the extent to which chaplains interact with military veterans at increased risk of suicide and select characteristics related to those at-risk veterans who present for chaplaincy services. Methods: The nationwide network of chaplains affiliated with the Veterans Health Administration (n = 990) was e-mailed a letter inviting those who have contact with at-risk veterans to complete a survey. This letter included an Internet link, connecting respondents to an online survey collection service. One hundred eighteen chaplains (11.91%) responded to the survey. Results: More than half of the respondents reported that veterans at increased risk of suicide constitute either <5% or 5% to 10% of the overall population of veterans under their care. At-risk veterans are most often identified based on open admission of suicidal behavior or red flags in their treatment file. Veterans typically do not look for chaplains from their own faith tradition, will seek care from >1 chaplain, and present at a moderate-to-high level of risk. Conclusions: The present study finds that some at-risk veterans look to chaplains for supportive services. The findings also allow for opportunities for future research. C1 [Kopacz, Marek S.] US Dept Vet Affairs, VISN Ctr Excellence Suicide Prevent 2, Canandaigua, NY 14424 USA. US Dept Vet Affairs, Natl Chaplain Ctr, Hampton, VA USA. RP Kopacz, MS (reprint author), US Dept Vet Affairs, VISN Ctr Excellence Suicide Prevent 2, 400 Ft Hill Ave, Canandaigua, NY 14424 USA. EM marek.kopacz@va.gov NR 39 TC 6 Z9 6 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD OCT PY 2014 VL 107 IS 10 BP 661 EP 664 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AU6WZ UT WOS:000345743400013 PM 25279873 ER PT J AU Padole, A Singh, S Ackman, JB Wu, C Do, S Pourjabbar, S Khawaja, RDA Otrakji, A Digumarthy, S Shepard, JA Kalra, M AF Padole, Atul Singh, Sarabjeet Ackman, Jeanne B. Wu, Carol Do, Synho Pourjabbar, Sarvenaz Khawaja, Ranish Deedar Ali Otrakji, Alexi Digumarthy, Subba Shepard, Jo-Anne Kalra, Mannudeep TI Submillisievert Chest CT With Filtered Back Projection and Iterative Reconstruction Techniques SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE chest CT; CT radiation dose reduction; filtered back projection; iterative reconstruction techniques ID COMPUTED-TOMOGRAPHY; DOSE REDUCTION; IMAGE QUALITY AB OBJECTIVE. The purpose of this study was to compare submillisievert chest CT images reconstructed with filtered back projection (FBP), SafeCT, adaptive statistical iterative reconstruction (ASIR), and model-based iterative reconstruction (MBIR) with standard of care FBP images. SUBJECTS AND METHODS. Fifty patients (33 men and 17 women; mean age [+/- SD], 62 +/- 10 years) undergoing routine chest CT gave written informed consent for acquisition of an additional submillisievert chest CT series with reduced tube current but identical scanning length as standard of care chest CT. Sinogram data of the submillisievert series were reconstructed with FBP, SafeCT, ASIR, and MBIR and compared with FBP images at standard-dose chest CT (n = 8 x 50 = 400 series). Two thoracic radiologists performed independent comparison for visualization of lesion margin, visibility of small structures, and diagnostic acceptability. Objective noise measurements and noise spectral density were obtained. RESULTS. Of 287 detected lesions, 162 were less than 1-cm noncalcified nodules. Lesion margins were well seen on all submillisievert reconstruction images except MBIR, on which they were poorly visualized. Likewise, only submillisievert MBIR images were suboptimal for visibility of normal structures, such as pulmonary vessels in the outer 2 cm of the lung, interlobular fissures, and subsegmental bronchial walls. MBIR had the lowest image noise compared with other techniques. CONCLUSION. FBP, SafeCT, ASIR, and MBIR can enable optimal lesion evaluation on chest CT acquired at a volume CT dose index of 2 mGy. However, all submillisievert reconstruction techniques were suboptimal for visualization of mediastinal structures. Submillisievert MBIR images were suboptimal for visibility of normal lung structures despite showing lower image noise. C1 [Padole, Atul; Singh, Sarabjeet; Ackman, Jeanne B.; Wu, Carol; Do, Synho; Pourjabbar, Sarvenaz; Khawaja, Ranish Deedar Ali; Otrakji, Alexi; Digumarthy, Subba; Shepard, Jo-Anne; Kalra, Mannudeep] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. RP Padole, A (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St,Founders 202, Boston, MA 02114 USA. EM apadole@partners.org FU Radiological Society of North America Research and Education Foundation; GE Healthcare; Siemens Healthcare; Philips Healthcare; Society of Thoracic Radiology FX M. Kalra and S. Singh have received Educational Scholar grants from the Radiological Society of North America Research and Education Foundation. S. Singh has received research grants from GE Healthcare, Siemens Healthcare, Philips Healthcare, and the Society of Thoracic Radiology. None of the other coauthors have any pertinent financial disclosures and had complete unrestricted access to the data at all times. NR 18 TC 13 Z9 13 U1 0 U2 5 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2014 VL 203 IS 4 BP 772 EP 781 DI 10.2214/AJR.13.12312 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AU3OP UT WOS:000345523500036 PM 25247943 ER PT J AU Harvey, HB Ahn, R Price, DD Burke, TF AF Harvey, H. Benjamin Ahn, Roy Price, Daniel D. Burke, Thomas F. TI Innovating for the Developing World: Meeting the Affordability Challenge SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE developing world; health policy; maternal health; ultrasound ID AFRICA; CARE AB OBJECTIVE. Ultrasound technologies have gained increasing prominence and accessibility in the developing world as manufacturers focus on this region as an emerging market. More extensive ultrasound use holds promise for addressing the disproportionate morbidity and mortality that continues to plague the developing world, particularly in the area of obstetrics. CONCLUSION. In this article, we describe the challenge of making ultrasound technologies affordable to health care providers in resource-limited regions vis-a-vis an innovative group of midwives in Nairobi. C1 [Harvey, H. Benjamin] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Harvey, H. Benjamin; Ahn, Roy; Burke, Thomas F.] Massachusetts Gen Hosp, Dept Emergency Med, Div Global Hlth & Human Rights, Boston, MA 02114 USA. [Harvey, H. Benjamin; Ahn, Roy; Burke, Thomas F.] Harvard Univ, Sch Med, Boston, MA USA. [Price, Daniel D.] Alameda Cty Med Ctr, Dept Emergency Med, Oakland, CA USA. RP Harvey, HB (reprint author), Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St,FND 216, Boston, MA 02114 USA. EM hbharvey@partners.org NR 10 TC 0 Z9 0 U1 1 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2014 VL 203 IS 4 BP 835 EP 837 DI 10.2214/AJR.14.12484 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AU3OP UT WOS:000345523500044 PM 25247949 ER PT J AU Agarwal, S Fuentes-Orrego, JM Arnason, T Misdraji, J Jhaveri, KS Harisinghani, M Hahn, PF AF Agarwal, Sheela Fuentes-Orrego, Jorge M. Arnason, Thomas Misdraji, Joseph Jhaveri, Kartik S. Harisinghani, Mukesh Hahn, Peter F. TI Inflammatory Hepatocellular Adenomas Can Mimic Focal Nodular Hyperplasia on Gadoxetic Acid-Enhanced MRI SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE contrast-enhanced MRI; gadoxetate disodium; inflammatory hepatocellular adenoma; liver imaging ID MALIGNANT-TRANSFORMATION; DIAGNOSIS; DISODIUM; LESIONS; CLASSIFICATION; SUBTYPES; LIVER AB OBJECTIVE. Inflammatory hepatocellular adenoma (HCA) is a recently categorized entity of hepatocellular neoplasms. We investigated whether gadoxetic acid-enhanced MRI can distinguish inflammatory HCA from focal nodular hyperplasia (FNH). MATERIALS AND METHODS. From January 1, 2009, through January 1, 2013, gadoxetic acid-enhanced MRI examinations from two institutions were reviewed for HCA, with specific histologic features of inflammatory HCA. Biopsy and resection slides were reviewed, and immunohistochemistry for glutamine synthetase was performed in a subset to confirm the initial diagnosis. RESULTS. A total of 10 possible cases of inflammatory HCA were identified in the pathology database. On the basis of glutamine synthetase staining performed for this study, three cases were rediagnosed as FNH and thus were excluded from the study. Therefore, a total of seven patients with inflammatory HCA were identified. On gadoxetic acid-enhanced MRI, four of these patients had classic features of FNH (group A, FNH mimics), and three had imaging features suggestive of HCA (group B, typical inflammatory HCA). Imaging features that were considered diagnostic of FNH included isointense or minimal T2 hyperintensity, arterial enhancement, and diffuse hyperintensity on hepatobiliary phase. Three of the four patients with FNH mimics had slides available for pathologic rereview, and the diagnosis of inflammatory HCA was supported by glutamine synthetase immunohistochemistry findings. The pathology reports of the remaining four cases were rereviewed and were also found to have features consistent with inflammatory HCA. CONCLUSION. Inflammatory HCA can mimic FNH on MRI, including hepatobiliary phase hyperintensity. Moreover, conventional pathology using histopathology alone may lead to misclassification of inflammatory HCA. C1 [Agarwal, Sheela; Fuentes-Orrego, Jorge M.; Harisinghani, Mukesh; Hahn, Peter F.] Massachusetts Gen Hosp, Dept Radiol, Div Abdominal Imaging, Boston, MA 02114 USA. [Agarwal, Sheela; Fuentes-Orrego, Jorge M.; Misdraji, Joseph; Harisinghani, Mukesh; Hahn, Peter F.] Harvard Univ, Sch Med, Boston, MA 02114 USA. [Arnason, Thomas] Queen Elizabeth 2 Hlth Sci Ctr, Div Anat Pathol, Halifax, NS, Canada. [Arnason, Thomas] Dalhousie Univ, Halifax, NS, Canada. [Misdraji, Joseph] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Jhaveri, Kartik S.] Univ Hlth Network, Univ Toronto, Dept Med Imaging, Toronto, ON, Canada. [Jhaveri, Kartik S.] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada. RP Agarwal, S (reprint author), Massachusetts Gen Hosp, Dept Radiol, Div Abdominal Imaging, 55 Fruit St, Boston, MA 02114 USA. EM sagarwal5@partners.org OI Fuentes-Orrego, Jorge/0000-0002-9254-0746 NR 30 TC 14 Z9 15 U1 1 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2014 VL 203 IS 4 BP W408 EP W414 DI 10.2214/AJR.13.12251 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AU3OP UT WOS:000345523500008 PM 25055198 ER PT J AU Howard, SA Gray, KP O'Donnell, EK Fennessy, FM Beard, CJ Sweeney, CJ AF Howard, Stephanie A. Gray, Kathryn P. O'Donnell, Elizabeth K. Fennessy, Fiona M. Beard, Clair J. Sweeney, Christopher J. TI Craniocaudal Retroperitoneal Node Length as a Risk Factor for Relapse From Clinical Stage I Testicular Germ Cell Tumor SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE craniocaudal; craniocaudal lymph nodes; retroperitoneal; testicular cancer; testis cancer ID CANCER STUDY-GROUP; SEMINOMA; SURVEILLANCE; MANAGEMENT; DISSECTION; DISEASE; TRIAL AB OBJECTIVE. The purpose of this study was to investigate whether retroperitoneal craniocaudal nodal length or nodal volume predicts relapse risk in stage I testicular cancer. MATERIALS AND METHODS. We retrospectively reviewed 826 testicular cancer patients. Of these 826 patients, 118 had stage I disease and either less than 2 years of surveillance or retroperitoneal lymph node dissection with no adjuvant chemotherapy. These patients formed our analytic cohort, and 3D nodal volumes and craniocaudal nodal length were measured. Association between relapse risk and craniocaudal nodal length and nodal volume was evaluated using univariable or multivariable logistic regression models adjusted for known prognostic factors. RESULTS. Sixty-six (56%) of 118 patients had nonseminomatous germ cell tumor and 52 (44%) had seminomatous germ cell tumor. Craniocaudal nodal length proved to be an independent risk factor in nonseminomatous germ cell tumors using a multivariable logistic regression model adjusting for other potential known risk factors of embryonal predominance and lymphovascular invasion. For every 3-mm increase in craniocaudal nodal length, the risk of relapse increased by 52% (odds ratio [OR], 1.52; 95% CI, 1.03-2.25). For patients with seminomas, only primary tumor size was an independent risk factor for relapse (1.34, 1.02-1.75). CONCLUSION. In nonseminomatous germ cell tumors, craniocaudal nodal length was shown to be associated with increased risk of relapse independently of other known risk factors. If validated in an independent cohort, craniocaudal nodal length could provide important additional information to inform management decisions in these patients. C1 [Howard, Stephanie A.; O'Donnell, Elizabeth K.; Fennessy, Fiona M.; Beard, Clair J.; Sweeney, Christopher J.] Dana Farber Canc Inst, Dept Oncol, Boston, MA 02115 USA. [Howard, Stephanie A.; O'Donnell, Elizabeth K.; Fennessy, Fiona M.; Beard, Clair J.; Sweeney, Christopher J.] Dana Farber Canc Inst, Dept Radiol, Boston, MA 02115 USA. [Howard, Stephanie A.; O'Donnell, Elizabeth K.; Fennessy, Fiona M.; Beard, Clair J.; Sweeney, Christopher J.] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA. [Howard, Stephanie A.; O'Donnell, Elizabeth K.; Fennessy, Fiona M.; Beard, Clair J.; Sweeney, Christopher J.] Brigham & Womens Hosp, Dept Oncol, Boston, MA 02115 USA. [Howard, Stephanie A.; O'Donnell, Elizabeth K.; Fennessy, Fiona M.; Beard, Clair J.; Sweeney, Christopher J.] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA. [Howard, Stephanie A.; O'Donnell, Elizabeth K.; Fennessy, Fiona M.; Beard, Clair J.; Sweeney, Christopher J.] Brigham & Womens Hosp, Dept Radiat Oncol, Boston, MA 02115 USA. [Howard, Stephanie A.; Gray, Kathryn P.; O'Donnell, Elizabeth K.; Fennessy, Fiona M.; Beard, Clair J.; Sweeney, Christopher J.] Harvard Univ, Sch Med, Boston, MA USA. [Gray, Kathryn P.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. RP Howard, SA (reprint author), Dana Farber Canc Inst, Dept Oncol, 450 Brookline Ave, Boston, MA 02115 USA. EM sahoward@partners.org NR 22 TC 1 Z9 1 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2014 VL 203 IS 4 BP W415 EP W420 DI 10.2214/AJR.13.11615 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AU3OP UT WOS:000345523500009 PM 25247970 ER PT J AU Scheinfeld, MH Avery, LL AF Scheinfeld, Meir H. Avery, Laura L. TI A Fifth Mesh Appearance: The Gas Density Mesh SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter C1 [Scheinfeld, Meir H.] Montefiore Med Ctr, Bronx, NY 10467 USA. [Avery, Laura L.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. RP Scheinfeld, MH (reprint author), Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA. OI Scheinfeld, Meir H/0000-0001-8880-4318 NR 3 TC 0 Z9 0 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2014 VL 203 IS 4 BP W449 EP W449 DI 10.2214/AJR.13.12429 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AU3OP UT WOS:000345523500015 PM 25247976 ER PT J AU Bonakdar, N Schilling, A Lennert, P Sporrer, M Gerum, RC Alonso, JL Goldmann, WH AF Bonakdar, Navid Schilling, Achim Lennert, Pablo Spoerrer, Marina Gerum, Richard C. Alonso, Jose Luis Goldmann, Wolfgang H. TI Measuring mechanical properties in cells: three easy methods for biologists SO CELL BIOLOGY INTERNATIONAL LA English DT Article DE cell stretching; endothelial cells; keratinocytes; magnetic tweezer rheology; mouse fibroblasts; traction microscopy ID UNIAXIAL CYCLIC STRETCH; SMOOTH-MUSCLE-CELLS; CYTOSKELETON; ADHESION; ACTIVATION; DYNAMICS; LOCOMOTION; SUBSTRATE; PRESTRESS; RHEOLOGY AB The mechanism by which cells sense stresses and transmit them throughout the cytoplasm and the cytoskeleton (CSK) and by which these mechanical signals are converted into biochemical signaling responses is not clear. Specifically, there is little direct experimental evidence on how intracellular CSK structural elements in living cells deform and transmit stresses in response to external mechanical forces. Existing theories have invoked various biophysical and biochemical mechanisms to explain how cells spread, deform, divide, move, and change shape in response to mechanical inputs, but rigorous tests in cells are lacking. The lack of data and understanding is preventing the identification of mechanisms and sites of mechano-regulation in cells. Here, we introduce and describe three unique and easy methods for biologists to determine mechanical properties and signaling events in cells. C1 [Bonakdar, Navid; Schilling, Achim; Lennert, Pablo; Spoerrer, Marina; Gerum, Richard C.; Goldmann, Wolfgang H.] Univ Erlangen Nurnberg, Dept Phys, D-91054 Erlangen, Germany. [Alonso, Jose Luis] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Charlestown, MA 02129 USA. RP Goldmann, WH (reprint author), Univ Erlangen Nurnberg, Dept Phys, D-91054 Erlangen, Germany. EM wgoldmann@biomed.uni-erlangen.de FU Bayerische Forschungsallianz; Deutscher Akademischer Austauschdienst (DAAD); Deutsche Forschungsgemeinschaft (DFG) FX We thank Astrid Mainka for her help. This work was supported in part by grants from Bayerische Forschungsallianz, Deutscher Akademischer Austauschdienst (DAAD), and Deutsche Forschungsgemeinschaft (DFG). NR 39 TC 1 Z9 1 U1 4 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1065-6995 EI 1095-8355 J9 CELL BIOL INT JI Cell Biol. Int. PD OCT PY 2014 VL 38 IS 10 BP 1227 EP 1232 DI 10.1002/cbin.10303 PG 6 WC Cell Biology SC Cell Biology GA AU3QQ UT WOS:000345529100017 PM 24803101 ER PT J AU Claessen, BE Henriques, JPS Jaffer, FA Mehran, R Piek, JJ Dangas, GD AF Claessen, Bimmer E. Henriques, Jose P. S. Jaffer, Farouc A. Mehran, Roxana Piek, Jan J. Dangas, George D. TI Stent Thrombosis A Clinical Perspective SO JACC-CARDIOVASCULAR INTERVENTIONS LA English DT Editorial Material C1 [Claessen, Bimmer E.; Henriques, Jose P. S.; Piek, Jan J.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Jaffer, Farouc A.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Mehran, Roxana; Dangas, George D.] Cardiovasc Res Fdn, New York, NY USA. [Mehran, Roxana; Dangas, George D.] Mt Sinai Med Ctr, New York, NY 10029 USA. RP Claessen, BE (reprint author), Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. NR 0 TC 26 Z9 27 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-8798 EI 1876-7605 J9 JACC-CARDIOVASC INTE JI JACC-Cardiovasc. Interv. PD OCT PY 2014 VL 7 IS 10 BP 1081 EP 1081 DI 10.1016/j.jcin.2014.05.016 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AU0BG UT WOS:000345287500015 PM 25341705 ER PT J AU Armstrong, EJ Sab, S Singh, GD Lim, W Yeo, KK Waldo, SW Patel, M Reeves, R MacGregor, JS Low, RI Shunk, KA Mahmud, E Rogers, JH AF Armstrong, Ehrin J. Sab, Shiv Singh, Gagan D. Lim, Wayland Yeo, Khung-Keong Waldo, Stephen W. Patel, Mitul Reeves, Ryan MacGregor, John S. Low, Reginald I. Shunk, Kendrick A. Mahmud, Ehtisham Rogers, Jason H. TI Predictors and Outcomes of Recurrent Stent Thrombosis Results From a Multicenter Registry SO JACC-CARDIOVASCULAR INTERVENTIONS LA English DT Article DE angiography; recurrent stent thrombosis; stent thrombosis ID PERCUTANEOUS CORONARY INTERVENTION; DRUG-ELUTING STENTS; ELEVATION MYOCARDIAL-INFARCTION; ANTIPLATELET THERAPY; CLOPIDOGREL RESISTANCE; CLINICAL PRESENTATION; NETWORK METAANALYSIS; BIFURCATION LESIONS; PLATELET REACTIVITY; RANDOMIZED-TRIAL AB OBJECTIVES The aim of this study was to determine the incidence, predictors, and outcomes of recurrent stent thrombosis (rST). BACKGROUND Patients who had an initial stent thrombosis (ST) develop may be at high risk of rST. METHODS We analyzed a multicenter California registry of angiographic definite ST at 5 academic hospitals from 2005 to 2013. A detailed review of the angiogram and procedure was performed of patients with and without rST. RESULTS Among 221 patients with a median follow-up of 3.3 years, definite or probable rST developed in 29, including 19 with angiographic definite rST. The cumulative hazard ratio (HR) of definite or probable rST was 16% at 1 year and 24% at 5 years, whereas the cumulative HR of angiographic definite rST was 11% at 1 year and 20% at 5 years. Despite similar angiographic results, patients who had rST develop had significantly greater peak creatine kinase at the time of initial ST (mean, 2,655 mg/dl vs. 1,654 mg/dl; p = 0.05) than those without rST. The 3-year rate of major adverse cardiovascular events was 50% for patients with rST compared with 22% for patients with a single ST (p = 0.01). After multivariable adjustment, independent predictors of definite/probable rST were age (HR: 1.4; 95 confidence interval [CI]: 1.1 to 1.8 per 10 years), bifurcation ST (HR: 4.4; 95% CI: 1.8 to 10.9), and proximal vessel diameter (HR: 1.8; 95% CI: 1.1 to 3.2 per millimeter). CONCLUSIONS rST represents an important cause of long-term morbidity and mortality after an initial ST. Bifurcation ST and a larger proximal reference vessel diameter are independently associated with an increased risk of rST. (C) 2014 by the American College of Cardiology Foundation. C1 [Armstrong, Ehrin J.] Univ Colorado Denver, Dept Med, Div Cardiol, Denver, CO 80220 USA. [Sab, Shiv; Singh, Gagan D.; Lim, Wayland; Yeo, Khung-Keong; Low, Reginald I.; Rogers, Jason H.] Univ Calif Davis, Dept Med, Div Cardiovasc Med, Davis, CA 95616 USA. [Yeo, Khung-Keong] Natl Heart Ctr, Dept Cardiol, Singapore, Singapore. [Waldo, Stephen W.] Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA. [Patel, Mitul; Reeves, Ryan; Mahmud, Ehtisham] Univ Calif San Diego, Dept Med, Div Cardiovasc Med, San Diego, CA 92103 USA. [MacGregor, John S.; Shunk, Kendrick A.] Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA. [Shunk, Kendrick A.] Vet Affairs Med Ctr, Dept Med, San Francisco, CA 94121 USA. RP Armstrong, EJ (reprint author), Univ Colorado Denver, Dept Med, 1055 Clermont St, Denver, CO 80220 USA. EM ehrin.armstrong@gmail.com FU Medtronic; Boston Scientific; Abbott Vascular; Accumetrics; Cordis; Sanofi-Aventis; Gilead; InfraRedx; Siemens Medical Systems FX Dr. Yeo is on the Speakers' Bureau of Abbott Vascular; and receives research funding from Medtronic. Dr. Patel is on the Advisory Board of The Medicines Company; and is a consultant for Access Closure. Dr. Lim is a consultant for Volcano. Dr. Low is a consultant for Abbott Vascular and Boston Scientific. Dr. Rogers is a consultant for Volcano, Medtronic, and Boston Scientific. Dr. Mahmud is on the Speakers' Bureau of Medtronic and Eli Lilly; is a consultant for Eli Lilly; and has received research support from Boston Scientific, Abbott Vascular, Accumetrics, Cordis, and Sanofi-Aventis. Dr. Shunk receives institutional research support from Abbott Vascular, Gilead, InfraRedx, and Siemens Medical Systems; and is a consultant for TransAortic Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. NR 40 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-8798 EI 1876-7605 J9 JACC-CARDIOVASC INTE JI JACC-Cardiovasc. Interv. PD OCT PY 2014 VL 7 IS 10 BP 1105 EP 1113 DI 10.1016/j.jcin.2014.05.017 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AU0BG UT WOS:000345287500019 PM 25341707 ER PT J AU Erdem, SS Khan, S Palanisami, A Hasan, T AF Erdem, S. Sibel Khan, Shazia Palanisami, Akilan Hasan, Tayyaba TI Rapid, low-cost fluorescent assay of beta-lactamase-derived antibiotic resistance and related antibiotic susceptibility SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE rapid diagnostic; beta-lactam; bodipy; quenching; fluorescence; point-of-care ID CLINICAL MICROBIOLOGY; INFECTIONS; DISK; TIME; PCR AB Antibiotic resistance (AR) is increasingly prevalent in low and middle income countries (LMICs), but the extent of the problem is poorly understood. This lack of knowledge is a critical deficiency, leaving local health authorities essentially blind to AR outbreaks and crippling their ability to provide effective treatment guidelines. The crux of the problem is the lack of microbiology laboratory capacity available in LMICs. To address this unmet need, we demonstrate a rapid and simple test of beta-lactamase resistance (the most common form of AR) that uses a modified beta-lactam structure decorated with two fluorophores quenched due to their close proximity. When the beta-lactam core is cleaved by beta-lactamase, the fluorophores dequench, allowing assay speeds of 20 min to be obtained with a simple, streamlined protocol. Furthermore, by testing in competition with antibiotics, the beta-lactamase-associated antibiotic susceptibility can also be extracted. This assay can be easily implemented into standard lab work flows to provide near real-time information of beta- lactamase resistance, both for epidemiological purposes as well as individualized patient care. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Erdem, S. Sibel; Khan, Shazia; Palanisami, Akilan; Hasan, Tayyaba] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA 02114 USA. RP Hasan, T (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA 02114 USA. EM thasan@mgh.harvard.edu FU Department of Defense/Air Force Office of Research (DOD/AFOSR) [FA9550-11-1-0331]; NIH/NIBIB (National Institute of Biomedical Imaging and Bioengineering) (Point of Care Technology in Primary Care) through CIMIT (Centre for Integration of Medicine and Innovation Technology) [U54 EB015408] FX We thank Dr. Mary Jane Ferraro (Microbiology Labs, Massachusetts General Hospital, Boston, Massachusetts, USA) for providing the S. aureus clinical isolates. We also thank Drs. Sarika Verma and Ulysses W. Sallum for useful early discussions. This research was funded by the Department of Defense/Air Force Office of Research (DOD/AFOSR) (Grant No. FA9550-11-1-0331) and NIH/NIBIB (National Institute of Biomedical Imaging and Bioengineering) (Point of Care Technology in Primary Care) through CIMIT (Centre for Integration of Medicine and Innovation Technology) (Grant No. U54 EB015408). SSE and SK contributed to the design, conduct and analyses of experiments, and the writing and preparation of the manuscript. AP contributed to the design and analyses of experiments and the writing and preparation of the manuscript. TH contributed to the study conception and design, writing of the manuscript, and overall supervision. All authors read and approved the final manuscript. NR 33 TC 1 Z9 1 U1 1 U2 10 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 EI 1560-2281 J9 J BIOMED OPT JI J. Biomed. Opt. PD OCT PY 2014 VL 19 IS 10 AR 105007 DI 10.1117/1.JBO.19.10.105007 PG 11 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA AU8HM UT WOS:000345837200014 PM 25321396 ER PT J AU Xuan, WJ Vatansever, F Huang, LY Hamblin, MR AF Xuan, Weijun Vatansever, Fatma Huang, Liyi Hamblin, Michael R. TI Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE traumatic brain injury; transcranial low level light therapy; Morris water maze; wire grip motion test; neurogenesis; BrdU; NeuN; double-cortin; TUJ-1; caspase-3; mitochondrial modulation ID TERM NEUROLOGICAL DEFICITS; NEURON-SPECIFIC TUBULIN; ADULT NEUROGENESIS; LIGHT THERAPY; IMPACT; RAT; NEUROPROTECTION; DYSFUNCTION; EXPRESSION; DEPRESSION AB The use of transcranial low-level laser (light) therapy (tLLLT) to treat stroke and traumatic brain injury (TBI) is attracting increasing attention. We previously showed that LLLT using an 810-nm laser 4 h after controlled cortical impact (CCI)-TBI in mice could significantly improve the neurological severity score, decrease lesion volume, and reduce Fluoro-Jade staining for degenerating neurons. We obtained some evidence for neurogenesis in the region of the lesion. We now tested the hypothesis that tLLLT can improve performance on the Morris water maze (MWM, learning, and memory) and increase neurogenesis in the hippocampus and subventricular zone (SVZ) after CCI-TBI in mice. One and (to a greater extent) three daily laser treatments commencing 4-h post-TBI improved neurological performance as measured by wire grip and motion test especially at 3 and 4 weeks post-TBI. Improvements in visible and hidden platform latency and probe tests in MWM were seen at 4 weeks. Caspase-3 expression was lower in the lesion region at 4 days post-TBI. Double-stained BrdU-NeuN (neuroprogenitor cells) was increased in the dentate gyrus and SVZ. Increases in double-cortin (DCX) and TUJ-1 were also seen. Our study results suggest that tLLLT may improve TBI both by reducing cell death in the lesion and by stimulating neurogenesis. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Xuan, Weijun] Guangxi Univ Chinese Med, Ruikang Hosp, Dept Otolaryngol, Nanning 530021, Peoples R China. [Xuan, Weijun; Vatansever, Fatma; Huang, Liyi; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Xuan, Weijun; Vatansever, Fatma; Huang, Liyi; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Huang, Liyi] Guangxi Med Univ, Affiliated Coll & Hosp 1, Dept Infect Dis, Nanning 530021, Peoples R China. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu OI Hamblin, Michael/0000-0001-6431-4605 FU US NIH [R01AI050875]; Air Force Office of Scientific Research [FA9550-13-1-0068]; US Army Medical Research Acquisition Activity Grant [W81XWH-09-1-0514]; US Army Medical Research and Materiel Command Grant [W81XWH-13-2-0067] FX This work was supported by US NIH Grant No. R01AI050875, by Air Force Office of Scientific Research Grant No. FA9550-13-1-0068, by US Army Medical Research Acquisition Activity Grant No. W81XWH-09-1-0514 and by US Army Medical Research and Materiel Command Grant No. W81XWH-13-2-0067. NR 45 TC 19 Z9 20 U1 0 U2 10 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 EI 1560-2281 J9 J BIOMED OPT JI J. Biomed. Opt. PD OCT PY 2014 VL 19 IS 10 AR 108003 DI 10.1117/1.JBO.19.10.108003 PG 15 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA AU8HM UT WOS:000345837200036 PM 25292167 ER PT J AU Liapakis, IE Paschalis, EI Zambacos, GJ Englander, M Mandrekas, AD AF Liapakis, Ioannis E. Paschalis, Eleftherios I. Zambacos, George J. Englander, Miriam Mandrekas, Apostolos D. TI Redraping of the fat and eye lift for the correction of the tear trough SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY LA English DT Article DE Redraping; Blepharoplasty; Mid-face lift; Tear trough ID COMPOSITE RHYTIDECTOMY; ORBICULARIS OCULI; BLEPHAROPLASTY; REJUVENATION; MIDFACE; DISSECTION; SUSPENSION; FACELIFT; MUSCLE; MALAR AB Introduction: Tear trough deformity is very difficult to correct. It can appear at relatively young age and it deepens over the years due to laxity and loss of structural support. We describe a technique for the correction of tear trough deformity and mid-face laxity by means of redraping blepharoplasty and lateral "eye lift". Materials and methods: Upper lid markings were made and removal of the excess skin was employed. The herniated fat was removed from the nasal fat pad. Using a subciliary incision the dissection was completed at the level of the orbital rim and the fat was repositioned with 5-0 Monocryl (poliglecaprone 25, Ethicon) sutures at the inner canthus to correct the tear trough. Subsequently, a canthopexy performed to secure the lower eyelid. We then dissected the cheek over the periosteum of the zygomatic bone-arch and the flap was suspended through a tunnel at the periosteum of the upper-lateral orbit by 5-0 Monocryl (poliglecaprone 25, Ethicon) suture. Results: Thirty-five procedures were performed between 2009 and 2013. Patients were followed for at least one year. Successful correction of the tear trough deformity with middle face elevation was achieved in all patients. Sclera show was noted in 7 patients but resolved over 3-6 months period with no surgical intervention. Diplopia was noted in 1 patient probably due to oedema and was released 4 weeks after the operation. The oedema was prolonged (more than 1.5 month) in 10 patients probably due to the lymphatic stasis. Conjunctivitis was also noted in 2 patients and was released by conservative treatment. Conclusion: Our technique of redraping blepharoplasty and mid-face lift describes a relatively new approach for the correction of the tear trough deformity and middle face laxity. It shows stable results for up to 4 years although longer follow-up is needed to confirm the stability of the correction. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. C1 [Liapakis, Ioannis E.] OpsisClin Plast & Reconstruct Surg, Iraklion 71304, Greece. [Paschalis, Eleftherios I.; Englander, Miriam] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA. [Zambacos, George J.; Mandrekas, Apostolos D.] Artion Plast Surg Ctr, Athens 15451, Greece. RP Liapakis, IE (reprint author), OpsisClin Plast & Reconstruct Surg, 48 Anogion St, Iraklion 71304, Greece. EM liapjo@yahoo.com NR 22 TC 1 Z9 1 U1 0 U2 1 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1010-5182 EI 1878-4119 J9 J CRANIO MAXILL SURG JI J. Cranio-MaxilloFac. Surg. PD OCT PY 2014 VL 42 IS 7 BP 1497 EP 1502 DI 10.1016/j.jcms.2014.04.020 PG 6 WC Dentistry, Oral Surgery & Medicine; Surgery SC Dentistry, Oral Surgery & Medicine; Surgery GA AU2TH UT WOS:000345469900072 PM 24962046 ER PT J AU Chagin, AS Kronenberg, HM AF Chagin, Andrei S. Kronenberg, Henry M. TI Role of G-proteins in the differentiation of epiphyseal chondrocytes SO JOURNAL OF MOLECULAR ENDOCRINOLOGY LA English DT Review DE bone; G proteins; intracellular signaling; parathyroid and bone; skeletal ID RECEPTOR MESSENGER-RNA; XL-ALPHA-S; GROWTH-PLATE; PTH/PTHRP RECEPTOR; BONE-DEVELOPMENT; SKELETAL DEVELOPMENT; SIGNAL-TRANSDUCTION; INDIAN HEDGEHOG; RENAL-FAILURE; IN-VIVO AB Herein, we review the regulation of differentiation of the growth plate chondrocytes by G-proteins. In connection with this, we summarize the current knowledge regarding each family of G-protein alpha subunit, specifically, G alpha(s), G alpha(q/11), G alpha(12/13), and G alpha(i/o). We discuss different mechanisms involved in chondrocyte differentiation downstream of G-proteins and different G-protein-coupled receptors (GPCRs) activating G-proteins in the epiphyseal chondrocytes. We conclude that among all G-proteins and GPCRs expressed by chondrocytes, Gas has the most important role and prevents premature chondrocyte differentiation. Receptor for parathyroid hormone (PTHR1) appears to be the major activator of Gas in chondrocytes and ablation of either one leads to accelerated chondrocyte differentiation, premature fusion of the postnatal growth plate, and ultimately short stature. C1 [Chagin, Andrei S.] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden. [Kronenberg, Henry M.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA. RP Chagin, AS (reprint author), Karolinska Inst, Dept Physiol & Pharmacol, Nanna Svartz Vagen 2, S-17177 Stockholm, Sweden. EM andrei.chagin@ki.se RI Chagin, Andrei/F-4080-2014 OI Chagin, Andrei/0000-0002-2696-5850 FU Swedish Research Council [521-2012-1543]; NIH [DK056246] FX The work was supported by The Swedish Research Council grant number 521-2012-1543 and NIH grant number DK056246. NR 54 TC 5 Z9 5 U1 0 U2 4 PU BIOSCIENTIFICA LTD PI BRISTOL PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT, ENGLAND SN 0952-5041 J9 J MOL ENDOCRINOL JI J. Mol. Endocrinol. PD OCT PY 2014 VL 53 IS 2 BP R39 EP R45 DI 10.1530/JME-14-0093 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AU5AU UT WOS:000345620300001 PM 24982242 ER PT J AU Samuels, J Grados, MA Riddle, MA Bienvenu, OJ Goes, FS Cullen, B Wang, Y Greenberg, BD Fyer, AJ McCracken, JT Geller, D Murphy, DL Knowles, JA Rasmussen, SA McLaughlin, NC Piacentini, J Pauls, DL Stewart, SE Shugart, YY Maher, B Pulver, AE Nestadt, G AF Samuels, Jack Grados, Marco A. Riddle, Mark A. Bienvenu, O. Joseph Goes, Fernando S. Cullen, Bernadette Wang, Ying Greenberg, Benjamin D. Fyer, Abby J. McCracken, James T. Geller, Dan Murphy, Dennis L. Knowles, James A. Rasmussen, Steven A. McLaughlin, Nicole C. Piacentini, John Pauls, David L. Stewart, S. Evelyn Shugart, Yin-Yao Maher, Brion Pulver, Ann E. Nestadt, Gerald TI Hoarding in children and adolescents with obsessive-compulsive disorder SO JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS LA English DT Article DE OCD; Children; Adolescents; Hoarding; Social reciprocity; Indecision ID OCD COLLABORATIVE GENETICS; FACTOR-ANALYZED SYMPTOM; YOUNG-CHILDREN; LIFE EVENTS; BEHAVIOR; DIMENSIONS; AUTISM; INDIVIDUALS; SAMPLE; SCHIZOPHRENIA AB Compared to studies in adults, there have been few studies of hoarding in children and adolescents with obsessive-compulsive disorder (OCD). In the current study, we evaluated OCD clinical features, Axis I disorders, and social reciprocity scores in 641 children and adolescents with OCD, of whom 163 (25%) had hoarding compulsions and 478 did not. We found that, as a group, youth with hoarding had an earlier age at onset and more severe lifetime OCD symptoms, poorer insight, more difficulty making decisions and completing tasks, and more overall impairment. The hoarding group also had a greater lifetime prevalence of panic disorder, specific phobia, burette disorder, and tics. As measured with the Social Reciprocity Scale, the hoarding group had more severe deficits in parent-rated domains of social communication, social motivation, and restricted interests and repetitive behavior. In a multivariable model, the overall social reciprocity score, age at onset of OCD symptoms, symmetry obsessions, and indecision were independently related to hoarding in these children and adolescents with OCD. These features should be considered as candidate risk factors for the development of hoarding behavior in pediatric OCD. (C) 2014 Elsevier Inc. All rights reserved. C1 [Samuels, Jack; Grados, Marco A.; Riddle, Mark A.; Bienvenu, O. Joseph; Goes, Fernando S.; Cullen, Bernadette; Wang, Ying; Pulver, Ann E.; Nestadt, Gerald] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA. [Greenberg, Benjamin D.; Rasmussen, Steven A.; McLaughlin, Nicole C.] Butler Hosp, Brown Med Sch, Dept Psychiat & Behav Sci, Providence, RI 02906 USA. [Fyer, Abby J.] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA. [Fyer, Abby J.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA. [McCracken, James T.; Piacentini, John] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Geller, Dan] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Murphy, Dennis L.] NIMH, Clin Sci Lab, NIH, Bethesda, MD 20892 USA. [McCracken, James T.] Univ So Calif, Sch Med, Dept Psychiat, Los Angeles, CA USA. [Murphy, Dennis L.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Pauls, David L.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA. [Pauls, David L.] Harvard Univ, Sch Med, Boston, MA USA. [Stewart, S. Evelyn] Univ British Columbia, Dept Psychiat, Fac Med, Vancouver, BC, Canada. [Shugart, Yin-Yao] NIMH, Unit Stat Genom, Div Intramural Res, Bethesda, MD 20892 USA. [Maher, Brion] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA. RP Samuels, J (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA. EM jacks@jhmi.edu OI Samuels, Jack/0000-0002-6715-7905; Stewart, S. Evelyn/0000-0002-0994-6383 FU National Institutes of Health [MH50214, MH071507, MH79487, MH079488, MH079489, MH07 9494, K23-MH-64543, NIH/NCRR/OPD-GCRC RR00052]; James E. Marshall OCD Foundation FX This work was supported by National Institutes of Health grants MH50214, MH071507, MH79487, MH079488, MH079489, MH07 9494, K23-MH-64543, NIH/NCRR/OPD-GCRC RR00052, and by the James E. Marshall OCD Foundation. The National Institutes of Health and the James E. Marshall OCD Foundation had no role in the study design, collection, data analysis and interpretation, or writing the manuscript. NR 63 TC 6 Z9 6 U1 7 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2211-3649 J9 J OBSESS-COMPULS REL JI J. Obsessive-Compuls. Relat. Disord. PD OCT PY 2014 VL 3 IS 4 BP 325 EP 331 DI 10.1016/j.jocrd.2014.08.001 PG 7 WC Psychiatry SC Psychiatry GA AU4TN UT WOS:000345604400004 PM 25309849 ER PT J AU Pauls, DL Fernandez, TV Mathews, CA State, MW Scharf, JM AF Pauls, David L. Fernandez, Thomas V. Mathews, Carol A. State, Matthew W. Scharf, Jeremiah M. TI The inheritance of Tourette Disorder: A review SO JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS LA English DT Article DE Tourette Disorder; Genetics; Review; OCD; ADHD ID OBSESSIVE-COMPULSIVE DISORDER; COPY NUMBER VARIANTS; HUMAN GENOME; HISTIDINE-DECARBOXYLASE; PSYCHIATRIC-DISORDERS; NEURITE OUTGROWTH; TIC DISORDERS; SLITRK1 GENE; ASSOCIATION; FAMILY AB Georges Gilles de la Tourette, in describing the syndrome that now bears his name, observed that the condition aggregated within families. Over the last three decades, numerous studies have confirmed this observation, and demonstrated that familial clustering is in part due to genetic factors. Recent studies are beginning to provide clues about the underlying genetic mechanisms important for the manifestation of some cases of Tourette Disorder (TD). Evidence has come from different study designs, such as nuclear families, twins, multigenerational families, and case-control samples, together examining the broad spectrum of genetic variation including cytogenetic abnormalities, copy number variants, genome-wide association of common variants, and sequencing studies targeting rare and/or de nova variation. Each of these classes of genetic variation holds promise for identifying the causative genes and biological pathways contributing to this paradigmatic neuropsychiatric disorder. (C) 2014 Elsevier Inc. All rights reserved. C1 [Pauls, David L.; Scharf, Jeremiah M.] Harvard Univ, Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Dept Psychiat,Med Sch,Ctr Human Genet Res, Boston, MA 02114 USA. [Fernandez, Thomas V.] Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06520 USA. [Fernandez, Thomas V.] Yale Univ, Dept Psychiat, Sch Med, New Haven, CT 06520 USA. [Mathews, Carol A.; State, Matthew W.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. [Scharf, Jeremiah M.] Harvard Univ, Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Dept Neurol,Med Sch,Ctr Human Genet Res, Boston, MA 02114 USA. RP Pauls, DL (reprint author), Harvard Univ, Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Dept Psychiat,Med Sch,Ctr Human Genet Res, Boston, MA 02114 USA. EM dpauls@pngu.mgh.harvard.edu; dpauls@pngu.mgh.harvard.edu RI Fernandez, Thomas/D-4295-2009 OI Fernandez, Thomas/0000-0003-0830-022X FU NIH [R01 NS016648, U01 NS040024, K23 MH085057, K02 NS085048, R01 MH096767, K08 MH099424, R01 MH092289] FX This work was supported by NIH Grants R01 NS016648 (DLP), U01 NS040024 (DLP/JMS), K23 MH085057 (JMS), K02 NS085048 (JMS), R01 MH096767 (CAM), K08 MH099424 (TVF) and R01 MH092289 (MWS) NR 66 TC 11 Z9 11 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2211-3649 J9 J OBSESS-COMPULS REL JI J. Obsessive-Compuls. Relat. Disord. PD OCT PY 2014 VL 3 IS 4 BP 380 EP 385 DI 10.1016/j.jocrd.2014.06.003 PG 6 WC Psychiatry SC Psychiatry GA AU4TN UT WOS:000345604400012 PM 25506544 ER PT J AU Arle, JE Carlson, KW Mei, LZ Iftimia, N Shils, JL AF Arle, Jeffrey E. Carlson, Kristen W. Mei, Longzhi Iftimia, Nicolae Shils, Jay L. TI Mechanism of Dorsal Column Stimulation to Treat Neuropathic but not Nociceptive Pain: Analysis With a Computational Model SO NEUROMODULATION LA English DT Article DE Chronic pain; dorsal column stimulation; gate control theory of pain; neural circuitry modeling; neuromodulation mechanism; neuropathic pain; spinal cord stimulation ID SPINAL-CORD STIMULATION; GATE-CONTROL-THEORY; SUBSTANTIA-GELATINOSA; PARKINSONIAN CIRCUITRY; SUPERFICIAL DORSAL; NEURAL-NETWORKS; DBS ELECTRODE; LAMINA-I; NEURONS; HORN AB ObjectiveStimulation of axons within the dorsal columns of the human spinal cord has become a widely used therapy to treat refractory neuropathic pain. The mechanisms have yet to be fully elucidated and may even be contrary to standard gate control theory. Our hypothesis is that a computational model provides a plausible description of the mechanism by which dorsal column stimulation (DCS) inhibits wide dynamic range (WDR) cell output in a neuropathic model but not in a nociceptive pain model. Materials and MethodsWe created a computational model of the human spinal cord involving approximately 360,000 individual neurons and dendritic processing of some 60 million synapsesthe most elaborate dynamic computational model of the human spinal cord to date. Neuropathic and nociceptive pain signals were created by activating topographically isolated regions of excitatory interneurons and high-threshold nociceptive fiber inputs, driving analogous regions of WDR neurons. Dorsal column fiber activity was then added at clinically relevant levels (e.g., A firing rate between 0 and 110Hz by using a 210-sec pulse width, 50-150Hz frequency, at 1-3V amplitude). ResultsAnalysis of the nociceptive pain, neuropathic pain, and modulated circuits shows that, in contradiction to gate control theory, 1) nociceptive and neuropathic pain signaling must be distinct, and 2) DCS neuromodulation predominantly affects the neuropathic signal only, inhibiting centrally sensitized pathological neuron groups and ultimately the WDR pain transmission cells. ConclusionWe offer a different set of necessary premises than gate control theory to explain neuropathic pain inhibition and the relative lack of nociceptive pain inhibition by using retrograde DCS. Hypotheses regarding not only the pain relief mechanisms of DCS were made but also regarding the circuitry of pain itself, both nociceptive and neuropathic. These hypotheses and further use of the model may lead to novel stimulation paradigms. C1 [Arle, Jeffrey E.; Carlson, Kristen W.; Mei, Longzhi] Beth Israel Deaconess Med Ctr, Dept Neurosurg, Boston, MA 02215 USA. [Arle, Jeffrey E.] Harvard Univ, Sch Med, Dept Neurosurg, Boston, MA USA. [Iftimia, Nicolae] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA. [Shils, Jay L.] Lahey Clin Fdn, Dept Neurosurg, Burlington, MA USA. [Shils, Jay L.] Tufts Univ, Sch Med, Boston, MA 02111 USA. RP Arle, JE (reprint author), Beth Israel Deaconess Med Ctr, Dept Neurosurg, 110 Francis St, Boston, MA 02215 USA. EM jarle@bidmc.harvard.edu FU Sydney Family Foundation FX The work contained in this paper was performed with generous support from the Sydney Family Foundation. NR 85 TC 3 Z9 3 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1094-7159 EI 1525-1403 J9 NEUROMODULATION JI Neuromodulation PD OCT PY 2014 VL 17 IS 7 BP 642 EP 655 DI 10.1111/ner.12178 PG 14 WC Medicine, Research & Experimental; Clinical Neurology SC Research & Experimental Medicine; Neurosciences & Neurology GA AU3KT UT WOS:000345512700005 PM 24750347 ER PT J AU Lehrner, A Allen, NE AF Lehrner, Amy Allen, Nicole E. TI Construct Validity of the Conflict Tactics Scales: A Mixed-Method Investigation of Women's Intimate Partner Violence SO PSYCHOLOGY OF VIOLENCE LA English DT Article DE assessment; Conflict Tactics Scales; intimate partner violence; mixed-methods; play; women ID DATING VIOLENCE; PHYSICAL AGGRESSION; COURTSHIP VIOLENCE; COLLEGE-STUDENTS; RELIABILITY; COUPLES; SYMMETRY; CONTEXT; FORMS; PLAY AB Objective: The Conflict Tactics Scales 2 (CTS; Straus, Hamby, Boney-McCoy, & Sugarman, 1996) is the most widely used measure of intimate partner violence (IPV), and it consistently indicates high rates of IPV by young women in dating relationships. However, the CTS has been criticized for not assessing the context of the acts it measures. This study undertook a mixed-method investigation of women's IPV, incorporating both the CTS and in-depth interviews, to contextualize women's CTS reports of their use of violence against dating partners. Method: Four hundred seventy-six female undergraduates who had been in a heterosexual dating relationship in the past year completed the CTS. Women were then purposively recruited for follow-up interviews in a balanced design across 4 groups defined by self-reports of IPV perpetration on the CTS, ranging from none to severe and/or frequent violence. Thirty-four women completed interviews. Results: Although women's CTS reports were consistent with rates reported in the literature, there were discrepancies with the interview data. Findings indicate that women report endorsing acts of playful wrestling/fighting (i.e., "roughhousing") and mock violence on the CTS, and that such behavior is common among undergraduate women. The directionality of IPV identified by the CTS was also inconsistent with interview data. Conclusions: The CTS may potentially miscategorize acts and individuals and inflate estimates of the frequency and severity of women's IPV in young, dating, nonclinical samples. Research and clinical implications include the need for clearer definitions of the construct of IPV and the development of alternative or complementary assessment measures. C1 [Lehrner, Amy] James J Peters VA Med Ctr, Bronx, NY USA. [Allen, Nicole E.] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA. RP Lehrner, A (reprint author), James J Peters Vet Affairs Med Ctr, Mental Hlth Patient Care Ctr, 526 OOMH PTSD 116-A,130 West Kingsbridge Rd, Bronx, NY 10468 USA. EM amy.lehrner@va.gov NR 55 TC 6 Z9 6 U1 2 U2 12 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 2152-0828 EI 2152-081X J9 PSYCHOL VIOLENCE JI Psychol. Violence PD OCT PY 2014 VL 4 IS 4 SI SI BP 477 EP 490 DI 10.1037/a0037404 PG 14 WC Psychology, Clinical; Criminology & Penology; Family Studies SC Psychology; Criminology & Penology; Family Studies GA AU6GD UT WOS:000345700800009 ER PT J AU Ryan, DP Doody, DP AF Ryan, Daniel P. Doody, Daniel P. TI Management of congenital tracheal anomalies and laryngotracheoesophageal clefts SO SEMINARS IN PEDIATRIC SURGERY LA English DT Article DE Congenital airway obstruction; Congenital tracheal stenosis; Congenital laryngeal anomalies; Surgery; Laryngotracheoesophageal cleft; Tracheal rings; Tracheomalacia ID SLIDE TRACHEOPLASTY; TRACHEOESOPHAGEAL FISTULA; SURGICAL-MANAGEMENT; SUBGLOTTIC STENOSIS; ESOPHAGEAL ATRESIA; FOLLOW-UP; CHILDREN; RECONSTRUCTION; REPAIR; IV AB Congenital obstructions and anomalies of the pediatric airway are rare problems that may be associated with mild symptoms or critical stenoses that may be life threatening in the first few days of life. This review provides an overview of the embryologic development of the airway, different congenital anomalies associated with airway development, and surgical correction that may be associated with good long-term outcome. (C) 2014 Published by Elsevier Inc. C1 [Ryan, Daniel P.; Doody, Daniel P.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pediat Surg, Boston, MA 02114 USA. RP Ryan, DP (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pediat Surg, 55 Fruit St, Boston, MA 02114 USA. EM dryan@partners.org NR 52 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1055-8586 EI 1532-9453 J9 SEMIN PEDIATR SURG JI Semin. Pediatr. Surg. PD OCT PY 2014 VL 23 IS 5 BP 257 EP 260 DI 10.1053/j.sempedsurg.2014.09.005 PG 4 WC Pediatrics; Surgery SC Pediatrics; Surgery GA AU4WX UT WOS:000345610300005 PM 25459009 ER EF