FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Hirota, S Liu, Q Lee, HS Hossain, MG Lacy-Hulbert, A McCarty, JH AF Hirota, Shinya Liu, Qian Lee, Hye Shin Hossain, Mohammad G. Lacy-Hulbert, Adam McCarty, Joseph H. TI The astrocyte-expressed integrin alpha v beta 8 governs blood vessel sprouting in the developing retina SO DEVELOPMENT LA English DT Article DE Extracellular matrix; Itgb8; Cell adhesion; Blood-retinal barrier; Angiogenesis; Mouse ID ALPHA-V INTEGRINS; TGF-BETA; VASCULAR MORPHOGENESIS; CEREBRAL-HEMORRHAGE; ANGIOGENESIS; BRAIN; MOUSE; VEGF; MICE; HOMEOSTASIS AB The mouse retina is vascularized after birth when angiogenic blood vessels grow and sprout along a pre-formed latticework of astrocytes. How astrocyte-derived cues control patterns of blood vessel growth and sprouting, however, remains enigmatic. Here, we have used molecular genetic strategies in mice to demonstrate that alpha v beta 8 integrin expressed in astrocytes is essential for neovascularization of the developing retina. Selective ablation of alpha v or beta 8 integrin gene expression in astrocytes leads to impaired blood vessel sprouting and intraretinal hemorrhage, particularly during formation of the secondary vascular plexus. These pathologies correlate, in part, with diminished alpha v beta 8 integrin-mediated activation of extracellular matrix-bound latent transforming growth factor beta s (TGF beta s) and defective TGF beta signaling in vascular endothelial cells, but not astrocytes. Collectively, our data demonstrate that alpha v beta 8 integrin is a component of a paracrine signaling axis that links astrocytes to blood vessels and is essential for proper regulation of retinal angiogenesis. C1 [Hirota, Shinya; Liu, Qian; Lee, Hye Shin; Hossain, Mohammad G.; McCarty, Joseph H.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA. [Lacy-Hulbert, Adam] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA. RP McCarty, JH (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA. EM jhmccarty@mdanderson.org OI Lacy-Hulbert, Adam/0000-0003-2162-0156 FU Ellison Medical Foundation [AG-NS-0324-06]; National Institutes of Neurological Disease and Stroke [R01NS059876] FX This research was supported by grants from The Ellison Medical Foundation [AG-NS-0324-06 to J.H.M.] and the National Institutes of Neurological Disease and Stroke [R01NS059876 to J.H.M.]. Deposited in PMC for immediate release. NR 49 TC 21 Z9 22 U1 0 U2 3 PU COMPANY OF BIOLOGISTS LTD PI CAMBRIDGE PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND SN 0950-1991 J9 DEVELOPMENT JI Development PD DEC 1 PY 2011 VL 138 IS 23 BP 5157 EP 5166 DI 10.1242/dev.069153 PG 10 WC Developmental Biology SC Developmental Biology GA 844TC UT WOS:000296769200011 PM 22069187 ER PT J AU Robinaugh, DJ Marques, L Traeger, LN Marks, EH Sung, SC Beck, JG Pollack, MH Simon, NM AF Robinaugh, Donald J. Marques, Luana Traeger, Lara N. Marks, Elizabeth H. Sung, Sharon C. Beck, J. Gayle Pollack, Mark H. Simon, Naomi M. TI Understanding the relationship of perceived social support to post-trauma cognitions and posttraumatic stress disorder SO JOURNAL OF ANXIETY DISORDERS LA English DT Article DE Posttraumic stress disorder; Social support; Post-trauma cognitions; Cognitive models ID MOTOR-VEHICLE ACCIDENTS; PSYCHOMETRIC PROPERTIES; INVENTORY PTCI; SEXUAL ASSAULT; RISK-FACTORS; PTSD; VICTIMS; PREDICTORS; SYMPTOMS; TRAUMA AB Poor social support in the aftermath of a traumatic event is a well-established risk factor for posttraumatic stress disorder (PTSD) among adult trauma survivors. Yet, a great deal about the relationship between social support and PTSD remains poorly understood. In this study, we analyzed data from 102 survivors of a serious motor vehicle accident (MVA) at 4 weeks (Time 1) and 16 weeks (Time 2) post-MVA. We assessed the role of perceived dyadic social support, positive dyadic interaction, and negative dyadic interaction in the development and maintenance of PTSD. In addition, we examined how these social support constructs work together with negative post-trauma cognitions to affect the maintenance of PTSD. Neither perceived social support nor the quality of social interaction (i.e., positive or negative) was associated with PTSD symptom severity at Time 1. However, among those with elevated PTSD symptom severity at Time 1, greater social support and positive social interaction and lower negative social interaction were each associated with reductions in PTSD symptom severity from Time 1 to Time 2. For social support and negative social interaction, this association ceased to be significant when jointly assessed with negative post-trauma cognitions, suggesting that perceived social support and negative dyadic interaction were associated with maintenance of PTSD symptom severity because of their association with negative post-trauma cognitions. These results provide support to models and treatments of PTSD that emphasize the role of negative post-trauma cognitions in maintenance of PTSD. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Robinaugh, Donald J.] Harvard Univ, Dept Psychol, Sch Med, Cambridge, MA 02138 USA. [Robinaugh, Donald J.; Marques, Luana; Traeger, Lara N.; Marks, Elizabeth H.; Sung, Sharon C.; Pollack, Mark H.; Simon, Naomi M.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Beck, J. Gayle] Univ Memphis, Dept Psychol, Memphis, TN 38152 USA. [Robinaugh, Donald J.] Harvard Univ, Grad Sch Arts & Sci, Dept Psychol, Cambridge, MA 02138 USA. RP Robinaugh, DJ (reprint author), Harvard Univ, Dept Psychol, Sch Med, 33 Kirkland St, Cambridge, MA 02138 USA. EM robinaug@fas.harvard.edu FU NIMH NIH HHS [R36 MH075383, R36 MH075383-02] NR 39 TC 28 Z9 29 U1 8 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-6185 J9 J ANXIETY DISORD JI J. Anxiety Disord. PD DEC PY 2011 VL 25 IS 8 BP 1072 EP 1078 DI 10.1016/j.janxdis.2011.07.004 PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 839UH UT WOS:000296394400012 PM 21820854 ER PT J AU Tucker, JD Tuminez, AS AF Tucker, Joseph D. Tuminez, Astrid S. TI Reframing the Interpretation of Sex Worker Health: A Behavioral-Structural Approach SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HIV PREVENTION; COMMUNITY INTERVENTION; CONDOM USE; INDIA; INFECTION; RISK; SONAGACHI; PROSTITUTION; ENVIRONMENT; PROJECT AB Expanding sexually transmitted infection (STI) epidemics in many parts of Asia increase the importance of effective human immunodeficiency virus (HIV)/STI prevention programs for female sex workers. Designing sex worker health research and programs demands a well-stated conceptual approach, especially when one is interpreting the relationship between local policy environments and sex worker health. However, the core principles of the 2 most common conceptual approaches used in sex worker health programs-abolitionism and empowerment-have frequently divergent assumptions and implications. The abolitionist approach sees major aspects of the sex industry as fundamentally coercive and exploitative of women and supports dismantling all or parts of the sex sector. The empowerment approach strengthens sex workers' agency and rights in order to build collective self-efficacy and have women invested in implementing their own HIV/STI prevention programs. This review compares these approaches using implication analysis and empirical cases from Asia. The misperception of an unresolvable gap between the 2 approaches ignores common ground that forms the basis of a new behavioral-structural conceptual framework. Explicitly accounting for the interaction between female sex worker behaviors and larger structures and policies, a behavioral-structural approach may provide a solid foundation for sex work research and programs. C1 [Tucker, Joseph D.] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Tucker, Joseph D.] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA. [Tucker, Joseph D.] Guangdong Prov Ctr Skin Dis & STD Control, STD Control Dept, Guangzhou, Guangdong, Peoples R China. [Tuminez, Astrid S.] Natl Univ Singapore, Lee Kuan Yew Sch Publ Policy, Singapore, Singapore. RP Tucker, JD (reprint author), Guangdong Prov STI Control Ctr, 10 Xian Lie Dong Heng Rd, Guangzhou 510500, Guangdong, Peoples R China. EM jtucker4@partners.org FU National Institutes of Health (NIH) [Fogarty K01]; US NIH [1K01TW008200-01A1]; University of North Carolina (UNC) Fogarty [NIH FIC D43 TW01039]; UNC Social Science Research on HIV/AIDS in China [NIH NICHD R24 HD056670-01]; Harvard Institute for Global Health FX This work was supported by the National Institutes of Health (NIH) (Fogarty K01 Award; US NIH 1K01TW008200-01A1 to J. D. T.), the University of North Carolina (UNC) Fogarty AIDS International Research and Training Program (NIH FIC D43 TW01039), the UNC Social Science Research on HIV/AIDS in China (NIH NICHD R24 HD056670-01), and the Harvard Institute for Global Health. NR 35 TC 10 Z9 10 U1 0 U2 16 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2011 VL 204 SU 5 BP S1206 EP S1210 DI 10.1093/infdis/jir534 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 843FV UT WOS:000296658600002 PM 22043033 ER PT J AU Tucker, JD Kaufman, J Bhabha, J Kleinman, A AF Tucker, Joseph D. Kaufman, Joan Bhabha, Jacqueline Kleinman, Arthur TI Sex Work and Sexually Transmitted Infections in Asia: A Biosocial Analysis SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article AB The Harvard University Asia Center hosted a symposium in October 2010 focused on sex work and sexually transmitted infections in Asia, engaging a biosocial approach to promote sexual health in this region. Asia has an estimated 151 million cases of curable sexually transmitted infections (STIs; eg, syphilis, gonorrhea, chlamydia) each year, with commercial sex interactions playing a large role in ongoing transmission. Substantial human movement and migration, gender inequalities, and incipient medical and legal systems in many states stymie effective STI control in Asia. The articles in this supplement provide theoretical and empirical pathways to improving the sexual health of those who sell and purchase commercial sex in Asia. The unintended health consequences of various forms of regulating commercial sex are also reviewed, emphasizing the need to carefully consider the medical and public health consequences of new and existing policies and laws. C1 [Tucker, Joseph D.] Massachusetts Gen Hosp, Dept Med, Div Infect Dis, Boston, MA 02114 USA. [Tucker, Joseph D.] Univ N Carolina Chapel Hill, Sch Med, Dept Med, Chapel Hill, NC USA. [Tucker, Joseph D.; Kleinman, Arthur] Harvard Univ, Asia Ctr, Cambridge, MA 02138 USA. [Kaufman, Joan; Bhabha, Jacqueline] Harvard Univ, John F Kennedy Sch Govt, Cambridge, MA 02138 USA. [Kaufman, Joan] Brandeis Univ, Heller Sch Social Policy & Management, Waltham, MA USA. [Bhabha, Jacqueline] Harvard Univ, Sch Law, Cambridge, MA 02138 USA. RP Tucker, JD (reprint author), Massachusetts Gen Hosp, Dept Med, Div Infect Dis, 55 Fruit St,GRJ 504, Boston, MA 02114 USA. EM jtucker4@partners.org FU Harvard Asia Center; Michael Crichton Fund; Harvard Institute for Global Health (HIGH); Harvard Medical School Social Medicine Department/Francois-Xavier Bagnoud Center for Health and Human Rights; Harvard University Fairbank Center for Chinese Studies; Harvard-Yenching Institute; National Institutes of Health John E. Fogarty International Center [FIC 1K01TW008200-01A1] FX This conference was supported by the Harvard Asia Center, the Michael Crichton Fund, the Harvard Institute for Global Health (HIGH) Global Infectious Disease Program, Harvard Medical School Social Medicine Department/Francois-Xavier Bagnoud Center for Health and Human Rights, Harvard University Fairbank Center for Chinese Studies, and the Harvard-Yenching Institute. This research was supported by the National Institutes of Health John E. Fogarty International Center Career Development Award (FIC 1K01TW008200-01A1 to J. T.). NR 8 TC 4 Z9 4 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2011 VL 204 SU 5 BP S1203 EP S1205 DI 10.1093/infdis/jir533 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 843FV UT WOS:000296658600001 PM 22043032 ER PT J AU Singh, H Asali, S Werner, LL DeAngelo, DJ Ballen, KK Amrein, PC Wadleigh, M Galinsky, I Neuberg, DS Fox, EA Stone, RM Attar, EC AF Singh, Harshabad Asali, Salma Werner, Lillian L. DeAngelo, Daniel J. Ballen, Karen K. Amrein, Philip C. Wadleigh, Martha Galinsky, Ilene Neuberg, Donna S. Fox, Edward A. Stone, Richard M. Attar, Eyal C. TI Outcome of older adults with cytogenetically normal AML (CN-AML) and FLT3 mutations SO LEUKEMIA RESEARCH LA English DT Article DE FLT3ITD; AML; Elderly patients; Dose intensive therapy ID ACUTE MYELOID-LEUKEMIA; MICRORNA-EXPRESSION SIGNATURES; INTERNAL TANDEM DUPLICATION; GROUP-B; ELDERLY-PATIENTS; PROGNOSTIC IMPACT; NORMAL KARYOTYPE; CANCER; GENE; AGE AB AML patients under the age of 60 whose blasts harbor a FLT3 internal tandem duplication (ITD) mutation have a higher relapse rate and inferior survival compared to those without this mutation. To determine if FLT3ITD also carries a negative prognostic impact in older adults receiving therapies commonly used in this age group, we retrospectively analyzed outcomes of patients >= 60 years with CN-AML according to FLT3 mutation status. We identified 91 newly diagnosed CN-AML patients, 55 with wild-type FLT3 and 36 with FLT3ITD. Of the 91 patients, 36 received supportive care and/or experimental therapies while the remaining 55 received induction chemotherapy, followed by allogeneic SCT in 17 of these patients. Based on univariate analysis, advanced age at diagnosis was significantly associated with shorter overall survival (OS) (p<.0001) while intensive therapies were associated with improved OS (p<.0001). In a multivariate analysis that accounted for type of treatment, patient age, gender, and WBC count, FLT3ITD was significantly associated with shorter OS compared to wtFLT3 [p=.001; hazard ratio (HR) = 2.23; 95% CI: 1.35-3.70]. Our data support the negative prognostic impact of FLT3ITD in older adults with CN-AML. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Singh, Harshabad; Asali, Salma; Ballen, Karen K.; Amrein, Philip C.; Attar, Eyal C.] Massachusetts Gen Hosp, Bone Marrow Transplant Unit, Boston, MA 02114 USA. [Werner, Lillian L.; Neuberg, Donna S.] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [DeAngelo, Daniel J.; Wadleigh, Martha; Galinsky, Ilene; Stone, Richard M.] Dana Farber Canc Inst, Adult Leukemia Program, Boston, MA 02115 USA. [Fox, Edward A.] Dana Farber Canc Inst, Mol Diagnost Lab, Boston, MA 02115 USA. [Fox, Edward A.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. RP Attar, EC (reprint author), Massachusetts Gen Hosp, Hematol & Oncol Unit, Ctr Canc, 100 Blossom St, Boston, MA 02114 USA. EM eattar@partners.org FU Judith Keen Postdoctoral Research Fellowship; Massachusetts General Hospital FX H.S. is supported by the Judith Keen Postdoctoral Research Fellowship. This research is funded in part by the Leukemia Discovery and Treatment Fund at Massachusetts General Hospital. NR 22 TC 5 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0145-2126 J9 LEUKEMIA RES JI Leuk. Res. PD DEC PY 2011 VL 35 IS 12 BP 1611 EP 1615 DI 10.1016/j.leukres.2011.05.032 PG 5 WC Oncology; Hematology SC Oncology; Hematology GA 844BE UT WOS:000296721500014 PM 21696826 ER PT J AU Antoniadis, AG Petridou, ET Antonopoulos, CN Dessypris, N Panagopoulou, P Chamberland, JP Adami, HO Gogas, H Mantzoros, CS AF Antoniadis, Antonios G. Petridou, Eleni Th Antonopoulos, Constantine N. Dessypris, Nick Panagopoulou, Paraskevi Chamberland, John P. Adami, Hans Olov Gogas, Helen Mantzoros, Christos S. TI Insulin resistance in relation to melanoma risk SO MELANOMA RESEARCH LA English DT Article DE adipocytokines; adiponectin; insulin resistance; leptin; melanoma; obesity ID CUTANEOUS MALIGNANT-MELANOMA; PLASMA ADIPONECTIN CONCENTRATIONS; MOLECULAR-WEIGHT ADIPONECTIN; BODY-MASS INDEX; METABOLIC SYNDROME; ENDOMETRIAL CANCER; ALCOHOL INTAKE; BREAST-CANCER; LEPTIN; OBESITY AB Obesity, deregulation of adipocytokines, and insulin resistance are interrelated and have been implicated in carcinogenesis. In search of novel risk factors for melanoma, we explored the association of this disease with insulin resistance in a small size, case-control study. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), serum leptin, and adiponectin levels were determined in 55 patients with incident melanoma and 165 age-matched and sex-matched controls. Odds ratios were derived after adjusting for skin type, medical history, sociodemographic, lifestyle, and anthropometric parameters. Among the controls, HOMA-IR correlated positively with BMI (r = 0.34; P = 0.0001), waist-to-hip ratio (r = 0.20; P = 0.01) and negatively with serum adiponectin (r = -0.21; P = 0.006), whereas the correlation with leptin was essentially null (r = 0.09; P = 0.27). The mean HOMA-IR was approximately 1.5 times higher in cases than in controls (P = 0.05). The established positive association of melanoma with skin type was evident in multiple logistic regression models and so was the association with increasing HOMA-IR quintile (odds ratio for the fifth quintile = 3.68; 95% confidence intervals 1.15-11.79, P = 0.02). The latter persisted after adjustment for anthropometric variables and adiponectin but was attenuated when leptin was introduced in the model. These findings point to insulin resistance as a potentially independent risk factor for melanoma and need to be confirmed by future larger studies, ideally allowing the control of the directionality of the association. Melanoma Res 21:541-546 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. C1 [Antoniadis, Antonios G.; Petridou, Eleni Th; Antonopoulos, Constantine N.; Dessypris, Nick; Panagopoulou, Paraskevi] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece. [Antoniadis, Antonios G.; Gogas, Helen] Univ Athens, Sch Med, Dept Internal Med 1, Laiko Hosp, GR-11527 Athens, Greece. [Adami, Hans Olov] Karolinska Intitutet, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Adami, Hans Olov] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Chamberland, John P.; Mantzoros, Christos S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol Diabet & Metab,Dept Internal Med, Boston, MA 02215 USA. [Chamberland, John P.; Mantzoros, Christos S.] Harvard Univ, Sch Med, Endocrinol Sect, VA Boston Healthcare Syst, Boston, MA USA. [Mantzoros, Christos S.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. RP Petridou, ET (reprint author), Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, GR-11527 Athens, Greece. EM epetrid@med.uoa.gr OI Chamberland, John/0000-0002-7862-1371; Antonopoulos, Constantine N./0000-0003-0696-695X FU National and Kapodistrian University of Athens in Greece; Beth Israel Deaconess Medical Center FX this research project was supported in part by the National and Kapodistrian University of Athens in Greece and a discretionary grant from Beth Israel Deaconess Medical Center to C.S. Mantzoros. NR 45 TC 19 Z9 20 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0960-8931 J9 MELANOMA RES JI Melanoma Res. PD DEC PY 2011 VL 21 IS 6 BP 541 EP 546 DI 10.1097/CMR.0b013e32834b0eeb PG 6 WC Oncology; Dermatology; Medicine, Research & Experimental SC Oncology; Dermatology; Research & Experimental Medicine GA 844LX UT WOS:000296749800010 PM 21946019 ER PT J AU Epelbaum, S Benisty, S Reyes, S O'Sullivan, M Jouvent, E During, M Herve, D Opherk, C Hernandez, K Kurtz, A Viswanathan, A Bousser, MG Dichgans, M Chabriat, H AF Epelbaum, S. Benisty, S. Reyes, S. O'Sullivan, M. Jouvent, E. Duering, M. Herve, D. Opherk, C. Hernandez, K. Kurtz, A. Viswanathan, A. Bousser, M. G. Dichgans, M. Chabriat, H. TI Verbal memory impairment in subcortical ischemic vascular disease A descriptive analysis in CADASIL SO NEUROBIOLOGY OF AGING LA English DT Article DE CADASIL; Vascular dementia; Episodic memory; Cognitive test; MRI ID MILD COGNITIVE IMPAIRMENT; SMALL VESSEL DISEASE; ALZHEIMERS-DISEASE; NORMATIVE DATA; RECOGNITION MEMORY; DEMENTIA; CRITERIA; INFARCTS; ATROPHY; STROKE AB In the elderly, the high prevalence of Alzheimer's disease neuropathology presents a major challenge to the investigation of memory decline in common diseases such as small vessel disease. CADASIL represents a unique clinical model to determine the spectrum of memory impairment in subcortical ischemic vascular dementia (SIVD). One hundred and forty CADASIL patients underwent detailed clinical, neuropsychological and imaging analyses. The Free and Cued Selective Reminding Test was used as a measure of verbal memory. Forty-four out of 140 CADASIL patients (31.4%) presented with memory impairment according to this test. Eight out of 44(18.2%) subjects with memory impairment matched the definition of the amnestic syndrome of hippocampal type. While alterations in spontaneous recall were related to the severity of subcortical ischemic lesions, the profile of memory impairment, particularly the sensitivity to cueing was found related to other factors such as hippocampal atrophy. (C) 2010 Elsevier Inc. All rights reserved. C1 [O'Sullivan, M.] Univ Cardiff, Wales Inst Cognit Neurosci, Cardiff, Wales. [Duering, M.; Opherk, C.; Dichgans, M.] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany. [Viswanathan, A.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Viswanathan, A.] Massachusetts Gen Hosp, Clin Trials Unit, Boston, MA 02114 USA. [Viswanathan, A.] Harvard Univ, Sch Med, Boston, MA USA. [Bousser, M. G.; Chabriat, H.] INSERM, U740, Fac Med Lariboisiere St Louis, Paris, France. RP Chabriat, H (reprint author), Hop Lariboisiere, Serv Neurol, 2 Rue Ambroise Pare, F-75010 Paris, France. EM stephane.epelbaum@psl.aphp.fr; hugues.chabriat@lrb.ap-hop-paris.fr RI O'Sullivan, Michael/A-1796-2010; Jouvent, Eric/I-6635-2012; Jouvent, Eric/B-4320-2014; Chabriat, Hugues/G-5699-2010 OI Jouvent, Eric/0000-0001-7797-2236; Chabriat, Hugues/0000-0001-8436-6074 FU French Ministry of Health [AOR 02-001]; Bouygues Company FX This work was supported by French Ministry of Health (PHRC grant AOR 02-001 (DRC/APHP)) and performed with the help of ARNEVA (Association de Recherche en Neurologie VAsculaire), Hopital Lariboisiere, France who received a grant under the corporate patronage of Bouygues Company. NR 60 TC 14 Z9 14 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0197-4580 J9 NEUROBIOL AGING JI Neurobiol. Aging PD DEC PY 2011 VL 32 IS 12 BP 2172 EP 2182 DI 10.1016/j.neurobiolaging.2009.12.018 PG 11 WC Geriatrics & Gerontology; Neurosciences SC Geriatrics & Gerontology; Neurosciences & Neurology GA 839PJ UT WOS:000296379900007 PM 20149485 ER PT J AU Bendlin, BB Canu, E Willette, A Kastman, EK McLaren, DG Kosmatka, KJ Xu, G Field, AS Colman, RJ Coe, CL Weindruch, RH Alexander, AL Johnson, SC AF Bendlin, B. B. Canu, E. Willette, A. Kastman, E. K. McLaren, D. G. Kosmatka, K. J. Xu, G. Field, A. S. Colman, R. J. Coe, C. L. Weindruch, R. H. Alexander, A. L. Johnson, S. C. TI Effects of aging and calorie restriction on white matter in rhesus macaques SO NEUROBIOLOGY OF AGING LA English DT Article DE Rhesus macaque; Diffusion tensor imaging; Magnetic resonance imaging; Aging; Caloric restriction; White matter ID LATERAL GENICULATE NEURONS; PRIMARY VISUAL-CORTEX; AGE-RELATED DECLINE; DIETARY RESTRICTION; BRAIN ABNORMALITIES; ALZHEIMERS-DISEASE; MYELIN BREAKDOWN; OXIDATIVE DAMAGE; HUMAN OBESITY; IN-VIVO AB Rhesus macaques on a calorie restricted diet (CR) develop less age-related disease, have virtually no indication of diabetes, are protected against sarcopenia, and potentially live longer. Beneficial effects of caloric restriction likely include reductions in age-related inflammation and oxidative damage. Oligodendrocytes are particularly susceptible to inflammation and oxidative stress, therefore, we hypothesized that CR would have a beneficial effect on brain white matter and would attenuate age-related decline in this tissue. CR monkeys and controls underwent diffusion tensor imaging (DTI). A beneficial effect of CR indexed by DTI was observed in superior longitudinal fasciculus, fronto-occipital fasciculus, external capsule, and brainstem. Aging effects were observed in several regions, although CR appeared to attenuate age-related alterations in superior longitudinal fasciculus, frontal white matter, external capsule, right parahippocampal white matter, and dorsal occipital bundle. The results, however, were regionally specific and also suggested that CR is not salutary across all white matter. Further evaluation of this unique cohort of elderly primates to mortality will shed light on the ultimate benefits of an adult-onset, moderate CR diet for deferring brain aging. Published by Elsevier Inc. C1 [Bendlin, B. B.; Canu, E.; Kastman, E. K.; McLaren, D. G.; Kosmatka, K. J.; Xu, G.; Weindruch, R. H.; Johnson, S. C.] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI 53705 USA. [Bendlin, B. B.; Canu, E.; Kastman, E. K.; McLaren, D. G.; Kosmatka, K. J.; Xu, G.; Weindruch, R. H.; Johnson, S. C.] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI USA. [Willette, A.; Coe, C. L.] Univ Wisconsin, Dept Psychol, Harlow Primate Lab, Madison, WI 53706 USA. [Willette, A.; Colman, R. J.; Coe, C. L.; Weindruch, R. H.] Wisconsin Natl Primate Res Ctr, Madison, WI USA. [Field, A. S.] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI 53706 USA. [Alexander, A. L.] Univ Wisconsin, Dept Psychiat, Sch Med & Publ Hlth, Madison, WI 53706 USA. [Alexander, A. L.] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA. [Alexander, A. L.] Waisman Lab Brain Imaging & Behav, Madison, WI USA. RP Johnson, SC (reprint author), William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, 2500 Overlook Terrace 11G, Madison, WI 53705 USA. EM scj@medicine.wisc.edu RI McLaren, Donald/G-9906-2011; Kastman, Erik/N-6645-2016; Canu, Elisa/K-1423-2016; OI Kastman, Erik/0000-0001-7221-9042; Canu, Elisa/0000-0001-5804-3378; Bendlin, Barbara/0000-0002-0580-9875 FU Waisman Center, UW-Madison; NIH [AG11915, RR000167, AG000213]; NCRR [RR15459-01, RR020141-01] FX The authors gratefully acknowledge the support of researchers and staff at the Waisman Center, UW-Madison, where MR imaging took place, and the technical assistance provided by S. Baum, J. Christensen, JA. Adriansjach, and C. E. Armstrong. We also acknowledge the assistance provided by the Animal Care, Veterinary and Pathology Staff of the Wisconsin National Primate Research Center. The project was supported by funding from the NIH to the Wisconsin National Primate Research Center grants AG11915 and RR000167 and NIH grant AG000213. This research was conducted in part at a facility constructed with support from Research Facilities Improvement Program grant numbers RR15459-01 and RR020141-01 from NCRR. The project also benefited from resources and facilities at the Wm. S. Middleton Memorial Veterans Hospital. GRECC Manuscript 2010-11. NR 67 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0197-4580 J9 NEUROBIOL AGING JI Neurobiol. Aging PD DEC PY 2011 VL 32 IS 12 AR 2319.e1 DI 10.1016/j.neurobiolaging.2010.04.008 PG 11 WC Geriatrics & Gerontology; Neurosciences SC Geriatrics & Gerontology; Neurosciences & Neurology GA 839PJ UT WOS:000296379900030 PM 20541839 ER PT J AU Chu, SH Roeder, K Ferrell, RE Devlin, B DeMichele-Sweet, MAA Kamboh, MI Lopez, OL Sweet, RA AF Chu, Su Hee Roeder, Kathryn Ferrell, Robert E. Devlin, Bernie DeMichele-Sweet, Mary Ann A. Kamboh, M. Ilyas Lopez, Oscar L. Sweet, Robert A. TI TOMM40 poly-T repeat lengths, age of onset and psychosis risk in Alzheimer disease SO NEUROBIOLOGY OF AGING LA English DT Article DE Apolipoprotein E (APOE) epsilon 4; Late-onset Alzheimer disease (LOAD); Psychosis; TOMM40; Variable length poly-T repeat sequence ID DEMENTIA; HERITABILITY; ASSOCIATION; APOE AB Apolipoprotein E (APOE) epsilon 4 alleles increase the risk for late-onset Alzheimer disease (LOAD) and decrease the age of onset. Recently, sequencing the APOE region in a small sample of LOAD subjects identified a variable length poly-T repeat sequence in the nearby gene, TOMM40, which may affect age of onset. We genotyped the TOMM40 poly-T repeat using a novel statistical approach to refine the identification of allele length in 892 LOAD subjects and evaluated its effects on age of onset. Because psychosis in LOAD is a heritable phenotype which has shown conflicting associations with APOE genotype, we also evaluated the association of poly-T repeat length with psychosis. Poly-T repeat lengths had a trimodal distribution which differed between APOE genotype groups. After accounting for APOE epsilon 4 there was no association of poly-T repeat length with age of onset. Neither APOE epsilon 4 nor poly-T repeat length was associated with psychosis. Our findings do not support the association of poly-T repeat length with age of onset in LOAD. The clinical implications of this repeat length polymorphism remain to be elucidated. (C) 2011 Elsevier Inc. All rights reserved. C1 [Chu, Su Hee; Roeder, Kathryn] Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA. [Ferrell, Robert E.; Kamboh, M. Ilyas] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA. [Devlin, Bernie; DeMichele-Sweet, Mary Ann A.; Kamboh, M. Ilyas; Lopez, Oscar L.; Sweet, Robert A.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA. [Lopez, Oscar L.; Sweet, Robert A.] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA. [Sweet, Robert A.] VA Pittsburgh Healthcare Syst, MIRECC, VISN Mental Illness Res Educ & Clin Ctr 4, Pittsburgh, PA USA. RP Sweet, RA (reprint author), Biomed Sci Tower,Rm W-1645,3811 OHara St, Pittsburgh, PA 15213 USA. EM sweetra@upmc.edu OI Kamboh, M. Ilyas/0000-0002-3453-1438 FU National Institute on Aging (NIA) [AG 027224, AG030653, AG 05133] FX This work was supported by National Institute on Aging (NIA) grants AG 027224, AG030653, and AG 05133. NR 19 TC 6 Z9 7 U1 3 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0197-4580 J9 NEUROBIOL AGING JI Neurobiol. Aging PD DEC PY 2011 VL 32 IS 12 AR 2328.e1 DI 10.1016/j.neurobiolaging.2011.06.016 PG 9 WC Geriatrics & Gerontology; Neurosciences SC Geriatrics & Gerontology; Neurosciences & Neurology GA 839PJ UT WOS:000296379900053 PM 21820212 ER PT J AU Wang, J Ono, K Dickstein, DL Arrieta-Cruz, I Zhao, W Qian, XJ Lamparello, A Subnani, R Ferruzzi, M Pavlides, C Ho, L Hof, PR Teplow, DB Pasinetti, GM AF Wang, Jun Ono, Kenjiro Dickstein, Dara L. Arrieta-Cruz, Isabel Zhao, Wei Qian, Xianjuan Lamparello, Ashley Subnani, Rakesh Ferruzzi, Mario Pavlides, Constantine Ho, Lap Hof, Patrick R. Teplow, David B. Pasinetti, Giulio M. TI Carvedilol as a potential novel agent for the treatment of Alzheimer's disease SO NEUROBIOLOGY OF AGING LA English DT Article DE Oligomeric A beta; Cognitive function; Spatial memory; Basal neuronal transmission; Dendritic spine; Synaptic plasticity; Bioavailability ID AMYLOID-BETA-PROTEIN; LONG-TERM POTENTIATION; SCANNING MICROSCOPY IMAGES; MOUSE MODEL; SYNAPTIC PLASTICITY; DENDRITIC SPINES; IN-VIVO; COGNITIVE FUNCTION; PREFRONTAL CORTEX; NATURAL OLIGOMERS AB Oligomeric beta-amyloid (A beta) has recently been linked to synaptic plasticity deficits, which play a major role in progressive cognitive decline in Alzheimer's disease (AD). Here we present evidence that chronic oral administration of carvedilol, a nonselective beta-adrenergic receptor blocker, significantly attenuates brain oligomeric beta-amyloid content and cognitive deterioration in 2 independent AD mouse models. We found that carvedilol treatment significantly improved neuronal transmission, and that this improvement was associated with the maintenance of number of the less stable "learning" thin spines in the brains of AD mice. Our novel observation that carvedilol interferes with the neuropathologic, biochemical, and electrophysiological mechanisms underlying cognitive deterioration in AD supports the potential development of carvedilol as a treatment for AD. (C) 2011 Elsevier Inc. All rights reserved. C1 [Wang, Jun; Arrieta-Cruz, Isabel; Zhao, Wei; Qian, Xianjuan; Lamparello, Ashley; Subnani, Rakesh; Ho, Lap; Pasinetti, Giulio M.] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA. [Wang, Jun; Ho, Lap; Pasinetti, Giulio M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA. [Ono, Kenjiro; Teplow, David B.] Univ Calif Los Angeles, Brain Res Inst, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90024 USA. [Ono, Kenjiro; Teplow, David B.] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA. [Dickstein, Dara L.; Hof, Patrick R.; Pasinetti, Giulio M.] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA. [Ferruzzi, Mario] Purdue Univ, Dept Food Sci, W Lafayette, IN 47907 USA. [Pavlides, Constantine] Rockefeller Univ, New York, NY 10021 USA. [Ho, Lap; Pasinetti, Giulio M.] James J Peters Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Bronx, NY USA. RP Pasinetti, GM (reprint author), Mt Sinai Sch Med, Dept Neurol, 1425 Madison Ave,Box 1230, New York, NY 10029 USA. EM giulio.pasinetti@mssm.edu RI Dickstein, Dara/F-3036-2013 FU NIH [UO1 AG29310]; Altschul Foundation FX This work is supported by NIH UO1 AG29310 (GMP) and funding provided by Altschul Foundation. NR 56 TC 5 Z9 6 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0197-4580 J9 NEUROBIOL AGING JI Neurobiol. Aging PD DEC PY 2011 VL 32 IS 12 AR 2321.e1 DI 10.1016/j.neurobiolaging.2010.05.004 PG 12 WC Geriatrics & Gerontology; Neurosciences SC Geriatrics & Gerontology; Neurosciences & Neurology GA 839PJ UT WOS:000296379900036 PM 20579773 ER PT J AU Misra, M Klibanski, A AF Misra, Madhusmita Klibanski, Anne TI Bone health in anorexia nervosa SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY LA English DT Article DE anorexia nervosa; bone density; bone microarchitecture; gonadal steroids; growth hormone; insulin-like growth factor-1 ID TRABECULAR STRUCTURE-ANALYSIS; MAPK SIGNALING PATHWAY; PANEL VOLUME CT; ADOLESCENT GIRLS; MINERAL DENSITY; GROWTH-HORMONE; SECRETORY DYNAMICS; HUMAN OSTEOBLASTS; DOUBLE-BLIND; YOUNG-WOMEN AB Purpose of review Anorexia nervosa is associated with low bone mineral density (BMD), concerning for an increased risk of fractures, and decreased bone accrual in adolescents, concerning for suboptimal peak bone mass. This review discusses causes of impaired bone health in anorexia nervosa and potential therapeutic strategies. Recent findings Low BMD in anorexia nervosa is consequent to decreased lean mass, hypogonadism, low insulin-like growth factor-1 (IGF-1), relative hypercortisolemia and alterations in hormones impacted by energy availability. Weight gain causes some improvement in bone accrual, but not to the extent observed in controls, and vitamin D supplementation does not increase BMD. Oral estrogen is not effective in increasing BMD, likely from IGF-1 suppressive effects. In contrast, transdermal estrogen replacement is effective in increasing bone accrual in adolescents with anorexia nervosa, although not to the extent seen in controls. Recombinant human IGF-1 increases bone formation in adolescents, and with oral estrogen increases BMD in adults with anorexia nervosa. Bisphosphonates increase BMD in adults, but not in adolescents, and should be used cautiously given their long half-life. Summary Further investigation is necessary to explore therapies for low BMD in anorexia nervosa. Weight gain is to be encouraged. Transdermal estrogen in adolescents, and bisphosphonates in adults, have a potential therapeutic role. C1 [Misra, Madhusmita; Klibanski, Anne] Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA. [Misra, Madhusmita] Harvard Univ, Sch Med, MassGen Hosp Children, Pediat Endocrine Unit, Boston, MA USA. RP Misra, M (reprint author), Massachusetts Gen Hosp, Neuroendocrine Unit, Bulfinch 457,55 Fruit St, Boston, MA 02114 USA. EM mmisra@partners.org FU National Institutes of Health [R01 DK 062249, K23 RR018851, 1 R01 HD060827-01A1, M01-RR-01066, 1 UL1 RR025758-03] FX This work was supported by National Institutes of Health Grants R01 DK 062249, K23 RR018851, 1 R01 HD060827-01A1, M01-RR-01066 and 1 UL1 RR025758-03. NR 65 TC 29 Z9 29 U1 0 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1752-296X EI 1752-2978 J9 CURR OPIN ENDOCRINOL JI Curr. Opin. Endocrinol. Diabetes Obes. PD DEC PY 2011 VL 18 IS 6 BP 376 EP 382 DI 10.1097/MED.0b013e32834b4bdc PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 841EV UT WOS:000296496200007 PM 21897220 ER PT J AU Gupta, AO Singh, N AF Gupta, Ashish O. Singh, Nina TI Immune reconstitution syndrome and fungal infections SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Review DE fungal infections; HIV; immune reconstitution syndrome; mycoses; transplants ID ORGAN TRANSPLANT RECIPIENTS; CRYPTOCOCCUS-NEOFORMANS INFECTION; PENICILLIUM-MARNEFFEI INFECTION; ADJUVANT CORTICOSTEROID-THERAPY; ACTIVE ANTIRETROVIRAL THERAPY; HIV-POSITIVE PATIENTS; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; INFLAMMATORY SYNDROME; DISSEMINATED HISTOPLASMOSIS AB Purpose of review Fungal infections-related immune reconstitution syndrome (IRS) poses challenging diagnostic and management issues in immunocompromised hosts. This review summarizes the current state of knowledge regarding its pathophysiologic basis, presentation, and treatment strategies. Recent findings Existing evidence suggests that IRS is a state of an imbalance between protective immunity and inflammatory pathology versus anti-inflammatory responses that restrain inflammation. IRS has been observed in diverse hosts including HIV-infected patients initiating potent antiretroviral therapy, transplant recipients, pregnant women, and recipients of iatrogenic biologic agents. Among the most common fungal infections associated with IRS is cryptococcosis, although this entity has been documented during the course of invasive aspergillosis, histoplasmosis, and candidiasis. Unique risk factors for IRS have been recognized in specific hosts. Summary IRS is a culmination of immunologic sequelae of host-pathogen interaction during evolution of an opportunistic infection, and as such the development of biomarkers that differentiate it from progressive disease would represent an important advance. Optimal management of immunosuppression and immunomodulatory approaches that target precise regulatory pathways for IRS warrant future investigations. C1 [Singh, Nina] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Gupta, Ashish O.] Univ Pittsburgh, Childrens Hosp, Div Hematol & Oncol, Pittsburgh, PA 15260 USA. RP Singh, N (reprint author), VA Med Ctr, Infect Dis Sect, Univ Dr C, Pittsburgh, PA 15240 USA. EM nis5@pitt.edu FU Pfizer FX N.S. has received investigator-initiated grant support from Pfizer. NR 71 TC 15 Z9 15 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD DEC PY 2011 VL 24 IS 6 BP 527 EP 533 DI 10.1097/QCO.0b013e32834ab20a PG 7 WC Infectious Diseases SC Infectious Diseases GA 841FB UT WOS:000296496800003 PM 22025021 ER PT J AU Lydall, GJ Bass, NJ McQuillin, A Lawrence, J Anjorin, A Kandaswamy, R Pereira, A Guerrini, I Curtis, D Vine, AE Sklar, P Purcell, SM Gurling, HMD AF Lydall, Gregory John Bass, Nicholas J. McQuillin, Andrew Lawrence, Jacob Anjorin, Adebayo Kandaswamy, Radhika Pereira, Ana Guerrini, Irene Curtis, David Vine, Anna E. Sklar, Pamela Purcell, Shaun M. Gurling, Hugh Malcolm Douglas TI Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder SO PSYCHIATRIC GENETICS LA English DT Article DE alcoholism; bipolar; comorbid; gene wise; genome-wide association ID AFFECTED SIB PAIR; HISTAMINE N-METHYLTRANSFERASE; ADDICTION MOLECULAR-GENETICS; SUBSTANCE USE DISORDERS; D-2 DOPAMINE-RECEPTOR; DRUG-DEPENDENCE; LINKAGE ANALYSIS; CANDIDATE GENES; FUNCTIONAL POLYMORPHISM; PROMOTER POLYMORPHISMS AB Objectives Alcoholism and affective disorders are both strongly comorbid and heritable. We have investigated the genetic comorbidity between bipolar affective disorder and alcoholism. Methods A genome-wide allelic association study of 506 patients from the University College London bipolar disorder case-control sample and 510 ancestrally matched supernormal controls. One hundred forty-three of the bipolar patients fulfilled the Research Diagnostic Criteria diagnosis of alcoholism. A total of 372 193 single nucleotide polymorphisms (SNPs) were genotyped. Genes previously shown to be associated with alcoholism and addiction phenotypes were then tested for association in the bipolar alcoholic sample using gene-wise permutation tests of all SNPs genotyped within a 50-kb region flanking each gene. Results Several central nervous system genes showed significant (P<0.05) gene-wise evidence of association with bipolar alcoholism. The genes implicated, which replicated genes previously shown to be associated with alcoholism were: cadherin 11, collagen type 11 alpha 2, neuromedin U receptor 2, exportin7, and semaphorin-associated protein 5A. The SNPs most strongly implicated in bipolar alcoholism, but, which did not meet conventional genome-wide significance criteria were the insulin-like growth factor-binding protein 7, carboxypeptidase O, cerebellin 2, and the cadherin 12 genes. Conclusion We have confirmed the role of some genes previously shown to be associated with alcoholism in the comorbid bipolar alcoholism subgroup. In this subgroup, bipolar disorder may lower the threshold for the phenotypic expression of these alcoholism susceptibility genes. We also show that some genes may independently increase susceptibility to affective disorder and alcoholism. Psychiatr Genet 21: 294-306 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. Psychiatric Genetics 2011, 21: 294-306 C1 [Lydall, Gregory John; Bass, Nicholas J.; McQuillin, Andrew; Lawrence, Jacob; Anjorin, Adebayo; Kandaswamy, Radhika; Pereira, Ana; Guerrini, Irene; Gurling, Hugh Malcolm Douglas] UCL, Mol Psychiat Lab, Dept Mental Hlth Sci, London W1T 4JF, England. [Curtis, David; Vine, Anna E.] Univ London, Barts & London Sch Med & Dent, Ctr Psychiat, London, England. [Sklar, Pamela; Purcell, Shaun M.] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA. [Sklar, Pamela; Purcell, Shaun M.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Sklar, Pamela; Purcell, Shaun M.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA. [Sklar, Pamela; Purcell, Shaun M.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Sklar, Pamela; Purcell, Shaun M.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Sklar, Pamela; Purcell, Shaun M.] Broad Inst Harvard & MIT, Cambridge, MA USA. RP Gurling, HMD (reprint author), UCL, Univ Coll Med Sch, Windeyer Inst Med Sci, Res Dept Mental Hlth Sci,Mol Psychiat Lab, London W1T 4JF, England. EM h.gurling@ucl.ac.uk RI Gurling, Hugh/A-5029-2010; McQuillin, Andrew/C-1623-2008 OI McQuillin, Andrew/0000-0003-1567-2240 FU UK Medical Research Council; Brain Damage Research Trust; Neuroscience Research Charitable Trust; Stanley Foundation; Stanley Psychiatric Research Center at the Broad Institute; Camden and Islington NHS Foundation Trust; Wellcome Trust [076392] FX Sources of support: funded by the UK Medical Research Council, The Brain Damage Research Trust, the Neuroscience Research Charitable Trust, the Stanley Foundation and the Stanley Psychiatric Research Center at the Broad Institute, and the Camden and Islington NHS Foundation Trust. Genotyping was carried out at the Broad Institute. A.E.V. is supported by Wellcome Trust Project Grant 076392. NR 123 TC 20 Z9 20 U1 6 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0955-8829 EI 1473-5873 J9 PSYCHIAT GENET JI Psychiatr. Genet. PD DEC PY 2011 VL 21 IS 6 BP 294 EP 306 DI 10.1097/YPG.0b013e32834915c2 PG 13 WC Genetics & Heredity; Neurosciences SC Genetics & Heredity; Neurosciences & Neurology GA 841ZT UT WOS:000296555000004 PM 21876473 ER PT J AU Kraft, S Mackler, E Schlickman, P Welch, K DePestel, DD AF Kraft, Shawna Mackler, Emily Schlickman, Peter Welch, Kathy DePestel, Daryl D. TI Outcomes of therapy: vancomycin-resistant enterococcal bacteremia in hematology and bone marrow transplant patients SO SUPPORTIVE CARE IN CANCER LA English DT Article DE Daptomycin; Linezolid; Vancomycin-resistant enterococci; Hematology; Bone marrow transplant; Bacteremia ID GRAM-POSITIVE INFECTIONS; BLOOD-STREAM INFECTION; FAECIUM BACTEREMIA; RISK-FACTORS; DAPTOMYCIN; MORTALITY; NEUTROPENIA; MULTICENTER; IMPACT AB The purpose of this study was to evaluate the risk factors associated with the treatment failure and 30-day mortality in hematology and bone marrow transplant patients treated with daptomycin or linezolid for vancomycin-resistant enterococci (VRE) bacteremia. The safety and tolerability of therapy was also assessed. This single-center, retrospective study included adult patients admitted to the hematology or bone marrow transplant service with documented vancomycin-resistant Enterococcus faecium or Enterococcus faecalis bacteremia and received at least 48 h of either linezolid or daptomycin as primary treatment. Clinical and microbiologic outcomes were assessed at day 7, 14, and 30 of hospital stay. A total of 72 patients were included in the analysis. Forty-three patients received daptomycin as primary treatment and 29 received linezolid as primary treatment. Overall success rate at day 7 was 81.9%, day 14 success rate was 79.2%, and day 30 success rate was 76.4% for all patients. Forty-one patients (57.0%) had high-grade bacteremia defined as greater than one positive blood culture for VRE. The mortality rate was significantly higher if high-grade bacteremia was present (34.1% vs. 7.0%; p = 0.009). This study suggests that linezolid and daptomycin are both reasonable options for treating VRE bacteremia in hematology and bone marrow transplant patients; however, patients with high-grade VRE bacteremia may be at increased risk for treatment failure. C1 [Kraft, Shawna; Mackler, Emily; DePestel, Daryl D.] Univ Michigan Hlth Syst, Dept Pharm, Ann Arbor, MI 48109 USA. [Schlickman, Peter] Denver VA Med Ctr, Dept Pharm, Denver, CO 80220 USA. [Welch, Kathy] Univ Michigan, Ctr Stat Consultat & Res, Ann Arbor, MI 48109 USA. RP Kraft, S (reprint author), Univ Michigan Hlth Syst, Dept Pharm, Ann Arbor, MI 48109 USA. EM svandeko@umich.edu FU Cubist Pharmaceuticals FX Dr. DePestel is a consultant for Pfizer and Cubist Pharmaceuticals and has received funding for other projects from Cubist Pharmaceuticals. All other authors have nothing to disclose. NR 19 TC 24 Z9 25 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0941-4355 J9 SUPPORT CARE CANCER JI Support. Care Cancer PD DEC PY 2011 VL 19 IS 12 BP 1969 EP 1974 DI 10.1007/s00520-010-1038-z PG 6 WC Oncology; Health Care Sciences & Services; Rehabilitation SC Oncology; Health Care Sciences & Services; Rehabilitation GA 839KA UT WOS:000296362900010 PM 21110047 ER PT J AU Jardin, BF LaRowe, SD Hall, BJ Malcolm, RJ AF Jardin, Bianca F. LaRowe, Steven D. Hall, Brian J. Malcolm, Robert J. TI The Obsessive Compulsive Cocaine Scale: Assessment of factor structure, reliability, and validity SO ADDICTIVE BEHAVIORS LA English DT Article DE Obsessive Compulsive Cocaine Scale; Cocaine; Confirmatory factor analysis; Psychometric properties ID DRINKING-SCALE; FIT INDEXES; ALCOHOL; BEHAVIOR; OCDS; QUANTIFICATION; QUESTIONNAIRE; DEPENDENCE; GOODNESS AB The present study assessed the factor structure, reliability, test retest, convergent validity, and predictive validity of the Obsessive Compulsive Cocaine Scale (OCCS), a newly developed questionnaire adapted from the Obsessive Compulsive Drinking Scale (OCDS). The questionnaire was administered to 189 cocaine-dependent individuals participating in two medication treatment trials for cocaine dependence. Confirmatory factor analysis of this measure revealed that it primarily assesses two factors, obsessions and compulsions. In addition, the data provided strong support for the internal consistency, test-retest reliability, predictive validity, and convergent validity of this two-factor measure. Overall, the data provide support for the psychometric strength of a modified version of the OCDS specifically designed to assess obsessive and compulsive cocaine use among those with cocaine dependence. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Jardin, Bianca F.; LaRowe, Steven D.; Hall, Brian J.] Charleston Consortium Psychol Internship Training, Charleston, SC 29425 USA. [LaRowe, Steven D.; Malcolm, Robert J.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Ctr Drug & Alcohol Programs, Charleston, SC 29425 USA. [LaRowe, Steven D.] Ralph H Johnson VAMC, Charleston, SC 29401 USA. RP Jardin, BF (reprint author), Charleston Consortium Psychol Internship Training, 67 President St, Charleston, SC 29425 USA. EM jardin@musc.edu OI Hall, Brian/0000-0001-9358-2377 FU NIDA [DA019903, DA016368] FX Funding for this study was provided by NIDA grants DA019903 and DA016368. NIDA had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. NR 29 TC 2 Z9 2 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 J9 ADDICT BEHAV JI Addict. Behav. PD DEC PY 2011 VL 36 IS 12 BP 1223 EP 1227 DI 10.1016/j.addbeh.2011.07.028 PG 5 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA 836LZ UT WOS:000296114500016 PM 21862227 ER PT J AU Paul, LA Grubaugh, AL Frueh, BC Ellis, C Egede, LE AF Paul, Lisa A. Grubaugh, Anouk L. Frueh, B. Christopher Ellis, Charles Egede, Leonard E. TI Associations between binge and heavy drinking and health behaviors in a nationally representative sample SO ADDICTIVE BEHAVIORS LA English DT Article DE Binge drinking; Heavy drinking; Health behaviors; Preventive care; BUSS ID ALCOHOL-CONSUMPTION; ADULTS; RISK; POPULATION; PATTERNS; DEFINITIONS; PREVALENCE; SERVICES; WOMEN; OLDER AB Background: Binge and heavy drinking are noted in the literature for their relatively high prevalence and adverse health-related effects. Design and participants: We used data from the 2006 Behavioral Risk Factor Surveillance Survey (BRFSS) to determine the associations between binge and heavy drinking and a wide range of health-related variables, including positive and negative health behaviors, preventive care practices, and quality of life indices in a nationally representative sample of 344,793 adults. Results: Rates of binge and heavy drinking in the current sample were 15% and 5%, respectively. Binge and heavy drinking were more common among men, younger adults, and individuals with higher incomes and at least some college education. After controlling for relevant demographic variables, binge and heavy drinking were associated with a number of adverse health-related and preventive care behaviors (e.g., smoking, failing to receive a mammogram), as well as less life satisfaction and a greater number of poor mental health days than those who did not engage in these drinking behaviors. Interestingly, binge and heavy drinking were also associated with some positive health-related variables (e.g., recent physical activity, positive perceptions of one's own health). Conclusions: The current study findings provide additional information regarding the relations between health-related attitudes and behaviors and binge and heavy drinking in the U.S. population. Implications of study findings are discussed. Published by Elsevier Ltd. C1 [Paul, Lisa A.; Grubaugh, Anouk L.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA. [Grubaugh, Anouk L.; Ellis, Charles; Egede, Leonard E.] Ralph H Johnson VA Med Ctr, Charleston VA REAP, Charleston, SC USA. [Frueh, B. Christopher] Univ Hawaii, Dept Psychol, Hilo, HI 96720 USA. [Frueh, B. Christopher] Menninger Clin, Houston, TX USA. [Ellis, Charles] Med Univ S Carolina, Dept Hlth Sci & Res, Charleston, SC 29425 USA. [Egede, Leonard E.] Med Univ S Carolina, Dept Med, Ctr Hlth Dispar Res, Charleston, SC 29425 USA. RP Grubaugh, AL (reprint author), Med Univ S Carolina, Dept Psychiat & Behav Sci, POB 250861, Charleston, SC 29425 USA. EM grubaugh@musc.edu FU NIDDK NIH HHS [K24 DK093699]; NIMH NIH HHS [T32 MH018869] NR 33 TC 18 Z9 19 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 J9 ADDICT BEHAV JI Addict. Behav. PD DEC PY 2011 VL 36 IS 12 BP 1240 EP 1245 DI 10.1016/j.addbeh.2011.07.034 PG 6 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA 836LZ UT WOS:000296114500019 PM 21868171 ER PT J AU Behlau, I Mukherjee, K Todani, A Tisdale, AS Cade, F Wang, LQ Leonard, EM Zakka, FR Gilmore, MS Jakobiec, FA Dohlman, CH Klibanov, AM AF Behlau, Irmgard Mukherjee, Koushik Todani, Amit Tisdale, Ann S. Cade, Fabiano Wang, Liqiang Leonard, Elizabeth M. Zakka, Fouad R. Gilmore, Michael S. Jakobiec, Frederick A. Dohlman, Claes H. Klibanov, Alexander M. TI Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials SO BIOMATERIALS LA English DT Article DE Antibacterial; Polyethylenimine (PEI); Keratoprosthesis; PMMA; Titanium; Corneal cytotoxicity ID STAPHYLOCOCCUS-AUREUS; ALKYLATED POLYETHYLENIMINE; INFECTIONS; ENDOPHTHALMITIS; COATINGS; BACTERIA; DEVICES; CULTURE; LENS AB The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, we observed that HMPEI-derivatized materials exert an inhibitory effect on biofilm formation by Staphylococcus aureus clinical isolates, as compared to the parent poly(methyl methacrylate) (PMMA) and titanium. There was no additional corneal epithelial cell cytotoxicity of HMPEI-coated PMMA compared to that of control PMMA in tissue cultures in vitro. Likewise, no toxicity or adverse reactivity was detected with HMPEI-derivatized PMMA or titanium compared to those of the control materials after intrastromal or anterior chamber implantation in rabbits in vivo. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Behlau, Irmgard; Leonard, Elizabeth M.] Massachusetts Eye & Ear Infirm, Henry Whittier Porter Bacteriol Lab, Boston, MA 02114 USA. [Behlau, Irmgard; Tisdale, Ann S.] Schepens Eye Res Inst, Boston, MA 02114 USA. [Mukherjee, Koushik; Klibanov, Alexander M.] MIT, Dept Chem, Cambridge, MA 02139 USA. [Mukherjee, Koushik; Klibanov, Alexander M.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Behlau, Irmgard] Mt Auburn Hosp, Dept Med, Div Infect Dis, Cambridge, MA 02138 USA. [Behlau, Irmgard; Zakka, Fouad R.; Gilmore, Michael S.; Jakobiec, Frederick A.; Dohlman, Claes H.] Harvard Univ, Sch Med, Boston, MA 02115 USA. RP Behlau, I (reprint author), Massachusetts Eye & Ear Infirm, Henry Whittier Porter Bacteriol Lab, 243 Charles St, Boston, MA 02114 USA. EM irmgard_behlau@meei.harvard.edu FU MEEI B-KPro Fund; Institute for Soldier Nanotechnologies at MIT through the U.S. Army Research Office [DAAD-19-D-0002]; NIH [EY017381] FX This work was made possible by the generous support of Fight for Sight Grant-In-Aid (LB.), MEEI B-KPro Fund, Institute for Soldier Nanotechnologies at MIT under contract through the U.S. Army Research Office DAAD-19-D-0002 (A.M.K.), and NIH grant EY017381 (M.S.G.). NR 39 TC 25 Z9 25 U1 3 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 J9 BIOMATERIALS JI Biomaterials PD DEC PY 2011 VL 32 IS 34 BP 8783 EP 8796 DI 10.1016/j.biomaterials.2011.08.010 PG 14 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 836LP UT WOS:000296113500004 PM 21903257 ER PT J AU Naeser, MA Martin, PI Theoret, H Kobayashi, M Fregni, F Nicholas, M Tormos, JM Steven, MS Baker, EH Pascual-Leone, A AF Naeser, Margaret A. Martin, Paula I. Theoret, Hugo Kobayashi, Masahito Fregni, Felipe Nicholas, Marjorie Tormos, Jose M. Steven, Megan S. Baker, Errol H. Pascual-Leone, Alvaro TI TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia SO BRAIN AND LANGUAGE LA English DT Article DE TMS; Brain stimulation; Aphasia; Stroke rehabilitation ID TRANSCRANIAL MAGNETIC STIMULATION; PARADOXICAL FUNCTIONAL FACILITATION; INFERIOR PREFRONTAL CORTEX; SPEECH-PERCEPTION; PREMOTOR CORTEX; NONFLUENT APHASIA; FRONTAL-CORTEX; GLOBAL APHASIA; BRAIN; RECOVERY AB This study sought to discover if an optimum 1 cm(2) area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. Published by Elsevier Inc. C1 [Naeser, Margaret A.; Martin, Paula I.; Nicholas, Marjorie; Baker, Errol H.] Boston Univ Sch Med, Harold Goodglass Boston Univ Aphasia Res Ctr, VA Boston Healthcare Syst, Boston, MA USA. [Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Steven, Megan S.; Pascual-Leone, Alvaro] Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA. [Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Steven, Megan S.; Pascual-Leone, Alvaro] Harvard Univ, Sch Med, Boston, MA USA. [Tormos, Jose M.; Pascual-Leone, Alvaro] Inst Guttmann, Barcelona, Spain. [Steven, Megan S.] Dartmouth Coll, Ctr Cognit Neurosci, Hanover, NH 03755 USA. RP Naeser, MA (reprint author), VA Boston Healthcare Syst, Aphasia Res Ctr 12A, JP Campus,150 So Huntington Ave, Boston, MA 02130 USA. EM mnaeser@bu.edu FU NIH [RO1 DC05672, RRO18875, P30 DC05207]; National Institute on Deafness and Other Communication Disorders, Bethesda, MD; Medical Research Service, Department of Veterans Affairs, Washington, D.C.; BBVA Chair in Translational Medicine, Harvard Clinical and Translational Science Center [UL1 RR025758, RO1-NS 47754, RO1-NS 20068]; Harvard-Thorndike General Clinical Research Center [NCRR MO1 RR01032]; National Institute on Deafness and Other Communication Disorders FX The authors would like to thank Mark Thivierge for the invaluable administrative support and Heidi Seekins for help with data acquisition and Michael Ho, Ph.D. for MRI assistance. Statement of Funding: Research supported by NIH Grant RO1 DC05672 from the National Institute on Deafness and Other Communication Disorders, Bethesda, MD and a grant from the Medical Research Service, Department of Veterans Affairs, Washington, D.C. (to M.A.N.); a K24 NIH award (RRO18875), BBVA Chair in Translational Medicine, Harvard Clinical and Translational Science Center (UL1 RR025758), RO1-NS 47754, and RO1-NS 20068 (to A.P.-L.); the Harvard-Thorndike General Clinical Research Center (NCRR MO1 RR01032); and NIH Grant P30 DC05207, National Institute on Deafness and Other Communication Disorders (to the Harold Goodglass Boston University Aphasia Research Center). NR 60 TC 52 Z9 57 U1 5 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0093-934X J9 BRAIN LANG JI Brain Lang. PD DEC PY 2011 VL 119 IS 3 BP 206 EP 213 DI 10.1016/j.bandl.2011.07.005 PG 8 WC Audiology & Speech-Language Pathology; Linguistics; Neurosciences; Psychology, Experimental SC Audiology & Speech-Language Pathology; Linguistics; Neurosciences & Neurology; Psychology GA 837RH UT WOS:000296220400010 PM 21864891 ER PT J AU Trenor, CC AF Trenor, Cameron C., III TI Sirolimus for Refractory Vascular Anomalies SO PEDIATRIC BLOOD & CANCER LA English DT Editorial Material ID KASABACH-MERRITT PHENOMENON; PROPRANOLOL TREATMENT; INFANTILE HEMANGIOMA; KAPOSIFORM HEMANGIOENDOTHELIOMA; INFANCY; HYPOGLYCEMIA C1 [Trenor, Cameron C., III] Childrens Hosp Boston, Div Hematol Oncol, Vasc Anomalies Ctr, Boston, MA 02215 USA. [Trenor, Cameron C., III] Dana Farber Canc Inst, Boston, MA 02215 USA. RP Trenor, CC (reprint author), Childrens Hosp Boston, Div Hematol Oncol, Vasc Anomalies Ctr, 300 Longwood Ave, Boston, MA 02215 USA. EM Cameron.trenor@childrens.harvard.edu NR 16 TC 6 Z9 7 U1 0 U2 0 PU WILEY PERIODICALS, INC PI SAN FRANCISCO PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD DEC PY 2011 VL 57 IS 6 BP 904 EP 905 DI 10.1002/pbc.23178 PG 2 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 825FX UT WOS:000295257700003 PM 21538825 ER PT J AU Billett, AL Reaman, GH AF Billett, Amy Louise Reaman, Gregory H. TI What Price Cure? SO PEDIATRIC BLOOD & CANCER LA English DT Editorial Material ID ACUTE LYMPHOBLASTIC-LEUKEMIA C1 [Billett, Amy Louise] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA. [Billett, Amy Louise] Childrens Hosp, Dept Med, Div Hematol Oncol, Boston, MA 02115 USA. [Billett, Amy Louise] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02215 USA. [Reaman, Gregory H.] US FDA, Off Oncol Drug Prod, Ctr Drug Evaluat & Res, Silver Spring, MD USA. RP Billett, AL (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, 450 Brookline Ave, Boston, MA 02215 USA. EM amy_billett@dfci.harvard.edu NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD DEC PY 2011 VL 57 IS 6 BP 908 EP 909 DI 10.1002/pbc.23302 PG 2 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 825FX UT WOS:000295257700005 PM 22010290 ER PT J AU Ferrari, A Sultan, I Huang, TT Rodriguez-Galindo, C Shehadeh, A Meazza, C Ness, KK Casanova, M Spunt, SL AF Ferrari, Andrea Sultan, Iyad Huang, Tseng Tien Rodriguez-Galindo, Carlos Shehadeh, Ahmad Meazza, Cristina Ness, Kirsten K. Casanova, Michela Spunt, Sheri L. TI Soft Tissue Sarcoma Across the Age Spectrum: A Population-Based Study From the Surveillance Epidemiology and End Results Database SO PEDIATRIC BLOOD & CANCER LA English DT Article DE age; epidemiology; prognosis; SEER; soft tissue sarcoma ID INDEPENDENT PROGNOSTIC-FACTOR; ADULT RHABDOMYOSARCOMA; POSTOPERATIVE NOMOGRAM; RETROSPECTIVE ANALYSIS; SINGLE INSTITUTION; INCIDENCE PATTERNS; RESULTS PROGRAM; PEDIATRIC-AGE; DIAGNOSIS; VALIDATION AB Background. Soft tissue sarcomas (STS) are a heterogeneous group of mesenchymal malignancies that occur throughout the life-span. The impact of age on disease features and outcome is unclear. Methods. We analyzed the clinical features and outcome of all STS cases registered between 1973 and 2006 in the SEER database. Results. There were 48,012 cases that met the selection criteria. Individuals less than 20 years of age represented 5.6%, with rhabdomyosarcoma being the most common subtype. In adults, the most common types were Kaposi sarcoma, fibrohistiocytic tumors, and leiomyosarcoma. Rhabdomyosarcoma was the only entity with a median age <20 years. Male predominance (male/female of 1.5:1) was noticed for almost all types of STS, except for alveolar soft part sarcoma and leiomyosarcoma. Tumor stage was similar across different age groups. Younger patients (<50 years) had significantly better survival than older patients (88.8 + 0.2% vs. 40 +/- 0.3%, P < 0.001), but for most histologies the survival decline with advancing age was gradual and did not occur abruptly at the onset of adulthood. The decline in survival with advancing age was particularly significant for rhabdomyosarcoma. Conclusion. With few exceptions, the clinical features of STS are similar in children and adults. However, individuals over 50 years of age have an inferior survival. Pediatr Blood Cancer 2011; 57: 943-949. (C) 2011 Wiley-Liss, Inc. C1 [Sultan, Iyad] King Hussein Canc Ctr, Dept Pediat Oncol, Amman 11941, Jordan. [Ferrari, Andrea; Meazza, Cristina; Casanova, Michela] Ist Nazl Tumori, Pediat Oncol Unit, I-20133 Milan, Italy. [Huang, Tseng Tien; Ness, Kirsten K.] St Jude Childrens Hosp, Dept Epidemiol & Canc Control, Memphis, TN 38105 USA. [Rodriguez-Galindo, Carlos] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Rodriguez-Galindo, Carlos] Harvard Univ, Sch Med, Childrens Hosp, Boston, MA 02115 USA. [Shehadeh, Ahmad] King Hussein Canc Ctr, Dept Surg, Orthoped Oncol Unit, Amman 11941, Jordan. [Spunt, Sheri L.] St Jude Childrens Hosp, Dept Oncol, Memphis, TN 38105 USA. [Spunt, Sheri L.] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Memphis, TN USA. RP Sultan, I (reprint author), King Hussein Canc Ctr, Dept Pediat Oncol, Queen Rania Al Abdullah St,POB 1269, Amman 11941, Jordan. EM isultan@khcc.jo RI Casanova, Michela/K-8436-2016; Meazza, Cristina/E-8191-2017; OI Casanova, Michela/0000-0003-0368-7883; Meazza, Cristina/0000-0002-1875-9563; Ferrari, Andrea/0000-0002-4724-0517 FU NCI NIH HHS [P30 CA021765] NR 30 TC 37 Z9 43 U1 0 U2 6 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD DEC PY 2011 VL 57 IS 6 BP 943 EP 949 DI 10.1002/pbc.23252 PG 7 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 825FX UT WOS:000295257700010 PM 21793180 ER PT J AU Truong, TH Weeks, JC Cook, EF Joffe, S AF Truong, Tony H. Weeks, Jane C. Cook, E. Francis Joffe, Steven TI Outcomes of Informed Consent Among Parents of Children in Cancer Clinical Trials SO PEDIATRIC BLOOD & CANCER LA English DT Article DE clinical trials; ethics; informed consent; outcomes; participant knowledge ID CHILDHOOD LEUKEMIA TRIALS; QUALITY; ONCOLOGY AB Background. Clinical trials are central to pediatric oncology, yet the process and outcomes of informed consent are poorly understood. We evaluated correlates of understanding among parents of pediatric trial participants, and explored differences in the process and outcome of informed consent between parents and a comparison group of adult participants. Procedure. We administered the Quality of Informed Consent (QuIC) to parents of children who were newly enrolled onto a cancer trial. We identified independent correlates of knowledge among parents, and compared parents' knowledge to that of a contemporaneous group of adult participants, using multiple linear regression models. Results. Parents (n = 47) were less likely than adult participants (n 204) to report having enough time to learn about the trial (64% vs. 87%, P = 0.001) or sufficient opportunity for questions (79% vs. 93%, P = 0.01), and reported lower overall satisfaction with the consent process (71% vs. 90%, P = 0.002). The mean parental knowledge score was 73.6 (95% confidence interval [CI] 69.5-77.8, theoretical maximum 100). Knowledge did not differ between parents and adult trial participants. In multivariate analysis, two predictors were significantly associated with higher parent knowledge scores: consent sought by the study's principal investigator (increment 13.6, CI 2.7-24.6) and physician-reported poor prognosis (increment 13.8, 95% CI 5.4-22.1). Conclusions. Although we observed no differences in knowledge between parents of pediatric cancer trial participants and their adult counterparts, parents report more problems with the informed consent process for their trials. The increased prevalence of problems is likely due to clinical and contextual differences between pediatric and adult trials. Pediatr Blood Cancer 2011; 57: 998-1004. (C) 2011 Wiley-Liss, Inc. C1 [Joffe, Steven] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Truong, Tony H.] Univ Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada. [Weeks, Jane C.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Cook, E. Francis] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Joffe, Steven] Childrens Hosp, Dept Med, Boston, MA 02115 USA. RP Joffe, S (reprint author), Dana Farber Canc Inst, Dept Pediat Oncol, 44 Binney St,Smith 207, Boston, MA 02115 USA. EM steven_joffe@dfci.harvard.edu OI Joffe, Steven/0000-0002-0667-7384 NR 25 TC 8 Z9 8 U1 0 U2 2 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD DEC PY 2011 VL 57 IS 6 BP 998 EP 1004 DI 10.1002/pbc.22983 PG 7 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 825FX UT WOS:000295257700018 PM 21280199 ER PT J AU Kenney, LB Bradeen, H Kadan-Lottick, NS Diller, L Homans, A Schwartz, CL AF Kenney, Lisa B. Bradeen, Heather Kadan-Lottick, Nina S. Diller, Lisa Homans, Alan Schwartz, Cindy L. TI The Current Status of Follow-Up Services for Childhood Cancer Survivors, Are We Meeting Goals and Expectations: A Report From the Consortium for New England Childhood Cancer Survivors SO PEDIATRIC BLOOD & CANCER LA English DT Article DE childhood cancer; follow-up care; regional collaboration; survivorship ID YOUNG-ADULT SURVIVORS; ADOLESCENT CANCER; 5-YEAR SURVIVORS; PRIMARY-CARE; HEALTH-CARE; DISEASE; RADIATION; FERTILITY; PROGRAMS; INSIGHTS AB Background. National guidelines for follow-up care of childhood cancer survivors have been established. It has not been determined if pediatric oncology programs have successfully incorporated these standards for long term survivor care into clinical practice. Methods. To describe survivor services available in a geographically and socio-economically diverse region of the US we surveyed all 12 academic institutions with pediatric oncology programs in the New England (NE) region. Results. Participating sites diagnose a median of 34 (range 10-250) new pediatric cancers annually. The 12 institutions have 11 survivor clinics. Clinics are staffed by: pediatric oncologists (11/11); nursepractitioners (7/11); social workers/psychologists (9/11); RNs (5/11); primary care physicians (3/11); and sub-specialists (3/11). Most clinics recommend annual follow-up for all survivors (7/11); however, point of entry into survivor programs is variable. Treatment summaries and care plans are part of survivor care at each program. Almost all (10/11) refer to sub-specialists to manage late effects. Only 4 programs identified a policy for transitioning survivors to adult care (2 to adult survivor programs, 2 to adult primary-care) and 4 reported this as a problem. Two clinics had no designated funding for survivor services; 8/11 receive institutional support; 5/11 philanthropic. Five institutions conduct research in survivorship (1 government-funded, 2 philanthropy-funded, and 2 both). Conclusions. Pediatric oncology services in the NE region are making progress toward meeting follow-up care goals for childhood cancer survivors. Funding for resource intense programs, transitioning care to adult clinical services, volume of sub-specialty referral, and participation in research are common challenges. Pediatr Blood Cancer 2011;57:1062-1066. (C) 2011 Wiley-Liss, Inc. C1 [Kenney, Lisa B.; Diller, Lisa] Dana Farber Canc Inst, Boston, MA 02115 USA. [Kenney, Lisa B.; Diller, Lisa] Childrens Hosp, Boston, MA 02115 USA. [Bradeen, Heather; Homans, Alan] Vermont Childrens Hosp, Burlington, VT USA. [Bradeen, Heather; Homans, Alan] Fletcher Allen Hlth Care, Burlington, VT USA. [Kadan-Lottick, Nina S.] Yale Canc Ctr, New Haven, CT USA. [Schwartz, Cindy L.] Hasbro Childrens Hosp, Providence, RI USA. RP Kenney, LB (reprint author), Dana Farber Canc Inst, D321,44 Binney St, Boston, MA 02115 USA. EM lisa_kenney@dfci.harvard.edu NR 27 TC 10 Z9 10 U1 1 U2 5 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD DEC PY 2011 VL 57 IS 6 BP 1062 EP 1066 DI 10.1002/pbc.22924 PG 5 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 825FX UT WOS:000295257700029 PM 21910208 ER PT J AU Choi, Y Marchani, EE Bird, TD Steinbart, EJ Blacker, D Wijsman, EM AF Choi, Yoonha Marchani, Elizabeth E. Bird, Thomas D. Steinbart, Ellen J. Blacker, Deborah Wijsman, Ellen M. TI Genome Scan of Age-at-Onset in the NIMH Alzheimer Disease Sample Uncovers Multiple Loci, Along With Evidence of Both Genetic and Sample Heterogeneity SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS LA English DT Article DE MCMC; oligogenic; Bayesian; dementia; linkage analysis ID BAYESIAN MODEL SELECTION; APOLIPOPROTEIN-E; LINKAGE ANALYSIS; WIDE ASSOCIATION; SEGREGATION ANALYSIS; QUANTITATIVE TRAIT; OLIGOGENIC SEGREGATION; CARIBBEAN HISPANICS; EPSILON-4 ALLELE; DUTCH POPULATION AB Alzheimer's disease (AD) is a common neurodegenerative disorder of late life with a complex genetic basis. Although several genes are known to play a role in rare early onset AD, only the APOE gene is known to have a high contribution to risk of the common late-onset form of the disease (LOAD, onset>60 years). APOE genotypes vary in their AD risk as well as age-at-onset distributions, and it is likely that other loci will similarly affect AD age-at-onset. Here we present the first analysis of age-at-onset in the NIMH LOAD sample that allows for both a multilocus trait model and genetic heterogeneity among the contributing sites, while at the same time accommodating age censoring, effects of known genetic covariates, and full pedigree and marker information. The results provide evidence for genomic regions not previously implicated in this data set, including regions on chromosomes 7q, 15, and 19p. They also affirm evidence for loci on chromosomes 1q, 6p, 9q, 11, and, of course, the APOE locus on 19q, all of which have been reported previously in the same sample. The analyses failed to find evidence for linkage to chromosome 10 with inclusion of unaffected subjects and extended pedigrees. Several regions implicated in these analyses in the NIMH sample have been previously reported in genome scans of other AD samples. These results, therefore, provide independent confirmation of AD loci in family-based samples on chromosomes 1q, 7q, 19p, and suggest that further efforts towards identifying the underlying causal loci are warranted. Published 2011 Wiley-Liss, Inc.(dagger) C1 [Marchani, Elizabeth E.; Bird, Thomas D.; Wijsman, Ellen M.] Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USA. [Choi, Yoonha; Wijsman, Ellen M.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Bird, Thomas D.; Steinbart, Ellen J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Div, Ctr Geriatr Res Educ & Clin, Seattle, WA USA. [Bird, Thomas D.; Steinbart, Ellen J.] Univ Washington, Dept Neurol, Seattle, WA 98195 USA. [Blacker, Deborah] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA USA. [Blacker, Deborah] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Wijsman, Ellen M.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. RP Wijsman, EM (reprint author), Univ Washington, Div Med Genet, Dept Med, Box 357720, Seattle, WA 98195 USA. EM wijsman@u.washington.edu OI Wijsman, Ellen/0000-0002-2725-6669 FU National Institute of Health (NIH) [P50 AG005136, T32 AG000258, N01 HG65403]; National Institute of Mental Health (NIMH) Alzheimer Disease Genetics Initiative [U01 MH46281, U01 MH46290, U01 MH46373]; National Institute of Aging (NIA); Veterans Affairs research funds; anonymous foundation FX Financial support was provided by National Institute of Health (NIH) grants P50 AG005136 and T32 AG000258 from the National Institute of Aging (NIA), Veterans Affairs research funds, and an anonymous foundation. Data and biomaterials for the NIMH sample were collected in three projects that participated in the National Institute of Mental Health (NIMH) Alzheimer Disease Genetics Initiative, funded from 1991 to 1998 by U01 MH46281 (M.S. Albert and D. Blacker), U01 MH46290 (S. Bassett, G.A. Chase, and M.F. Folstein) and U01 MH46373 (R.C.P. Go and L.E. Harrell). Genotyping services were provided by the Center for Inherited Disease Research, which is fully funded through a federal contract from the NIH to The Johns Hopkins University, Contract Number N01 HG65403. NR 70 TC 4 Z9 4 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4841 EI 1552-485X J9 AM J MED GENET B JI Am. J. Med. Genet. B PD DEC PY 2011 VL 156B IS 7 BP 785 EP 798 DI 10.1002/ajmg.b.31220 PG 14 WC Genetics & Heredity; Psychiatry SC Genetics & Heredity; Psychiatry GA 824OE UT WOS:000295210600005 PM 21812099 ER PT J AU Harrison, MR Hahn, NM Pili, R Oh, WK Hammers, H Sweeney, C Kim, K Perlman, S Arnott, J Sidor, C Wilding, G Liu, G AF Harrison, Michael R. Hahn, Noah M. Pili, Roberto Oh, William K. Hammers, Hans Sweeney, Christopher Kim, KyungMann Perlman, Scott Arnott, Jamie Sidor, Carolyn Wilding, George Liu, Glenn TI A phase II study of 2-methoxyestradiol (2ME2) NanoCrystalA (R) dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC) SO INVESTIGATIONAL NEW DRUGS LA English DT Article DE Prostate cancer; Castrate-resistant; Antiangiogenesis; Antiproliferative; PET scan; Clinical trials ID POSITRON-EMISSION-TOMOGRAPHY; ENDOTHELIAL GROWTH-FACTOR; ENDOGENOUS ESTROGEN METABOLITE; MITOXANTRONE PLUS PREDNISONE; INHIBITS ANGIOGENESIS; TUMOR ANGIOGENESIS; CLINICAL-TRIAL; CHEMOTHERAPY; DOCETAXEL; CARCINOMA AB Purpose: 2ME2 (PanzemA (R)) is a non-estrogenic derivative of estradiol with antiproliferative and antiangiogenic activity. Preclinical data support antitumor activity in prostate cancer. This trial evaluated the efficacy of 2ME2 NCD in patients with taxane-refractory, metastatic CRPC. Experimental Design: Patients with metastatic CRPC who had progressed on only one prior taxane-based regimen were eligible. All patients received 2ME2 NCD at 1,500 mg orally four times daily, repeated in 28 day cycles. The primary endpoint was progression-free survival at month 6, with a secondary endpoint of PSA response. An exploratory endpoint was metabolic response on FDG-PET imaging. Results: A total of 50 pts was planned. The study was terminated after 21 pts when a futility analysis showed the primary endpoint was unlikely to be reached. The median number of cycles on study was 2 (range < 1 to 12). Adverse events (AE) of grade a parts per thousand yen3 related to the study drug occurred in 7 unique patients (33%): elevations in liver function tests, fatigue or weakness, gastrointestinal hemorrhage, and hyponatremia. Paired FDG-PET scans were obtained for 11 pts. No metabolic responses were observed. Conclusions: 2ME2 NCD did not appear to have clinically significant activity in this study. 2ME2 NCD was well-tolerated and showed some evidence of biologic activity. Given the aggressive biology in this taxane-refractory population, the potential benefit from a cytostatic agent like 2ME2 might better be realized in the pre-chemotherapy (or rising PSA only) stage of CRPC. C1 [Harrison, Michael R.; Kim, KyungMann; Perlman, Scott; Wilding, George; Liu, Glenn] Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53705 USA. [Hahn, Noah M.] Indiana Univ, Simon Canc Ctr, Indianapolis, IN 46204 USA. [Pili, Roberto] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Oh, William K.] Mt Sinai Med Ctr, Tisch Canc Inst, New York, NY 10029 USA. [Hammers, Hans] Johns Hopkins Kimmel Canc Ctr, Baltimore, MD USA. [Sweeney, Christopher] Dana Farber Canc Inst, Boston, MA 02115 USA. [Arnott, Jamie; Sidor, Carolyn] EntreMed Inc, Rockville, MD USA. [Harrison, Michael R.; Perlman, Scott; Liu, Glenn] Univ Wisconsin, Translat Imaging Res TIR Grp, Madison, WI 53705 USA. [Harrison, Michael R.; Hammers, Hans; Sweeney, Christopher; Kim, KyungMann; Wilding, George; Liu, Glenn] Dept Def Prostate Canc Clin Trials Consortium, New York, NY USA. RP Harrison, MR (reprint author), Univ Wisconsin, Carbone Canc Ctr, WIMR Room 7131,1111 Highland Ave, Madison, WI 53705 USA. EM mrharris@medicine.wisc.edu RI Oh, William/B-9163-2012 OI Oh, William/0000-0001-5113-8147 FU EntreMed, Inc.; Department of Defense Prostate Cancer Clinical Trial Consortium [P30 CA14520]; Prostate Cancer Foundation Therapy Consortium FX EntreMed, Inc. (sponsor/funding); Department of Defense Prostate Cancer Clinical Trial Consortium Award (P30 CA14520); Prostate Cancer Foundation Therapy Consortium. NR 51 TC 33 Z9 33 U1 0 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6997 J9 INVEST NEW DRUG JI Invest. New Drugs PD DEC PY 2011 VL 29 IS 6 BP 1465 EP 1474 DI 10.1007/s10637-010-9455-x PG 10 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA 819KQ UT WOS:000294824200038 PM 20499131 ER PT J AU Estrada, CA Krishnamoorthy, P Smith, A Staton, L Korf, MJ Allison, JJ Houston, TK AF Estrada, Carlos A. Krishnamoorthy, Periyakaruppan Smith, Ann Staton, Lisa Korf, Michele J. Allison, Jeroan J. Houston, Thomas K. TI Marketing to Increase Participation in a Web-Based Continuing Medical Education Cultural Competence Curriculum SO JOURNAL OF CONTINUING EDUCATION IN THE HEALTH PROFESSIONS LA English DT Article DE marketing; continuing medical education; Internet; Web; online; cultural competence ID ONLINE CME AB Introduction: CME providers may be interested in identifying effective marketing strategies to direct users to specific content. Online advertisements for recruiting participants into activities such as clinical trials, public health programs, and continuing medical education (CME) have been effective in some but not all studies. The purpose of this study was to compare the impact of 2 marketing strategies in the context of an online CME cultural competence curriculum (www.c-comp.org). Methods: In an interrupted time-series quasi-experimental design, 2 marketing strategies were tested: (1) wide dissemination to relevant organizations over a period of approximately 4 months, and (2) Internet paid search using Google Ads (5 consecutive 8-week periods-control 1, cultural/CME advertisement, control 2, hypertension/content advertisement, control 3). Outcome measures were CME credit requests, Web traffic (visits per day, page views, pages viewed per visit), and cost. Results: Overall, the site was visited 19,156 times and 78,160 pages were viewed. During the wide dissemination phase, the proportion of visits requesting CME credit decreased between the first (5.3%) and second (3.3%) halves of this phase (p = .04). During the Internet paid search phase, the proportion of visits requesting CME credit was highest during the cultural/CME advertisement period (control 1, 1.4%; cultural/CME ad, 4.3%; control 2, 1.5%; hypertension/content ad, 0.6%; control 3, 0.8%; p < .001). All measures of Web traffic changed during the Internet paid search phase (p < .01); however, changes were independent of the advertisement periods. The incremental cost for the cultural advertisement per CME credit requested was US$0.64. Discussion: Internet advertisement focusing on cultural competence and CME was associated with about a threefold increase in requests for CME credit at an incremental cost of under US$1; however, Web traffic changes were independent of the advertisement strategy. C1 [Estrada, Carlos A.] Univ Alabama, Birmingham Vet Affairs Med Ctr, Div Gen Internal Med, VA Natl Qual Scholars Program, Birmingham, AL 35294 USA. [Estrada, Carlos A.] Univ Alabama, DSCE, REAP Ctr Surg Med Acute Care Res & Transit C SMAR, Birmingham VA Med Ctr, Birmingham, AL 35294 USA. [Krishnamoorthy, Periyakaruppan] Univ Alabama, Div Continuing Med Educ, Birmingham, AL 35294 USA. [Smith, Ann] Univ Alabama, Div Prevent Med, UAB Minor Hlth & Hlth Dispar Res Ctr, Birmingham, AL 35294 USA. [Staton, Lisa] Univ Tennessee, Coll Med Chattanooga, Knoxville, TN 37996 USA. [Houston, Thomas K.] Univ Massachusetts, Sch Med, CHQOER, Bedford VAMC, Amherst, MA 01003 USA. [Houston, Thomas K.] Univ Massachusetts, Sch Med, Div Hlth Informat & Implementat Sci, Amherst, MA 01003 USA. RP Estrada, CA (reprint author), Univ Alabama, Birmingham Vet Affairs Med Ctr, Div Gen Internal Med, VA Natl Qual Scholars Program, 732 Fac Off Tower,510 20th St S, Birmingham, AL 35294 USA. EM cestrada@uab.edu RI Houston, Thomas/F-2469-2013; OI Allison, Jeroan/0000-0003-4472-2112 FU National Heart, Lung, and Blood Institute [K07 HL081373-01] FX This study was funded by a grant from the National Heart, Lung, and Blood Institute (K07 HL081373-01) to Dr. Estrada; approved by the institutional review boards of the University of Alabama at Birmingham; and presented in part at the 2009 and 2010 Southern Society of General Internal Medicine Annual Meetings, New Orleans, Louisiana. The authors report no conflict of interest. NR 23 TC 4 Z9 4 U1 0 U2 4 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 0894-1912 J9 J CONTIN EDUC HEALTH JI J. Contin. Educ. Health Prof. PD WIN PY 2011 VL 31 IS 1 BP 21 EP 27 DI 10.1002/chp.20097 PG 7 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 738AL UT WOS:000288611600004 PM 21425356 ER PT J AU Brown, JA Beaser, RS Neighbours, J Shuman, J AF Brown, Julie A. Beaser, Richard S. Neighbours, James Shuman, Jill TI The Integrated Joslin Performance Improvement/CME Program: A New Paradigm for Better Diabetes Care SO JOURNAL OF CONTINUING EDUCATION IN THE HEALTH PROFESSIONS LA English DT Article DE performance improvement; education; continuing; medical; Internet; diabetes; primary care ID CONTINUING MEDICAL-EDUCATION; SELF-ASSESSMENT; STRATEGIES; OUTCOMES AB Ongoing continuing medical education is an essential component of life- long learning and can have a positive influence on patient outcomes. However, some evidence suggests that continuing medical education has not fulfilled its potential as a performance improvement (PI) tool, in part due to a paradigm of CME that has focused on the quantity of continuing medical education credits attained rather than the quality of outcomes. The Joslin Diabetes Center has undertaken a new performance-based CME program model that offers performance improvement and continuing medical education as a unified entity that is convenient and accessible for the overburdened primary care physician. This paper describes the origins of the Joslin Professional Educational Continuum as well as its infrastructure and intended outcomes. C1 [Brown, Julie A.; Beaser, Richard S.; Neighbours, James] Joslin Diabet Ctr, Dept Profess Educ, Boston, MA USA. [Beaser, Richard S.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. RP Shuman, J (reprint author), 71 Hammond Pl, Woburn, MA 01801 USA. EM writersgroup@comcast.net NR 27 TC 8 Z9 8 U1 1 U2 1 PU WILEY PERIODICALS, INC PI SAN FRANCISCO PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA SN 0894-1912 EI 1554-558X J9 J CONTIN EDUC HEALTH JI J. Contin. Educ. Health Prof. PD WIN PY 2011 VL 31 IS 1 BP 57 EP 63 DI 10.1002/chp.20101 PG 7 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 738AL UT WOS:000288611600009 PM 21425361 ER PT J AU Qureshi, SU Long, ME Bradshaw, MR Pyne, JM Magruder, KM Kimbrell, T Hudson, TJ Jawaid, A Schulz, PE Kunik, ME AF Qureshi, Salah U. Long, Mary E. Bradshaw, Major R. Pyne, Jeffrey M. Magruder, Kathy M. Kimbrell, Timothy Hudson, Teresa J. Jawaid, Ali Schulz, Paul E. Kunik, Mark E. TI Does PTSD Impair Cognition Beyond the Effect of Trauma? SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; SMALLER HIPPOCAMPAL VOLUME; NEUROPSYCHOLOGICAL FUNCTION; ALZHEIMERS-DISEASE; EXECUTIVE FUNCTION; WORKING-MEMORY; SURVIVORS; SYMPTOMS; VETERANS; DEFICITS AB This systematic review analyzed data from studies examining memory and cognitive function in subjects with posttraumatic stress disorder (PTSD), compared with subjects exposed to trauma (but without PTSD). Based on analysis of 21 articles published in English from 1968 to 2009, the conclusion is that individuals with PTSD, particularly veterans, show signs of cognitive impairment when tested with neuropsychological instruments, more so than individuals exposed to trauma who do not have PTSD. (The Journal of Neuropsychiatry and Clinical Neurosciences 2011; 23:16-28) C1 [Qureshi, Salah U.; Long, Mary E.; Kunik, Mark E.] Michael E DeBakey Vet Affairs VA Med Ctr, Hlth Serv Res & Dev Serv, Houston Ctr Qual Care & Utilizat Studies, Houston, TX USA. [Qureshi, Salah U.; Schulz, Paul E.] Baylor Coll Med, Neurosensory Ctr, Houston, TX 77030 USA. [Qureshi, Salah U.; Schulz, Paul E.] Michael E DeBakey VA Med Ctr, Neurol Care Line, Houston, TX USA. [Qureshi, Salah U.; Long, Mary E.; Kimbrell, Timothy; Kunik, Mark E.] Baylor Coll Med, VA S Cent Mental Illness Res Educ & Clin Ctr, Houston, TX 77030 USA. [Bradshaw, Major R.; Jawaid, Ali; Schulz, Paul E.] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA. [Pyne, Jeffrey M.; Kimbrell, Timothy; Hudson, Teresa J.] Univ Arkansas Med Sci, Ctr Mental Hlth & Outcomes Res, Cent Arkansas Vet Healthcare Syst, Coll Med, Little Rock, AR 72205 USA. [Pyne, Jeffrey M.; Kimbrell, Timothy; Hudson, Teresa J.] Univ Arkansas Med Sci, Coll Med, Dept Psychiat, Little Rock, AR 72205 USA. [Magruder, Kathy M.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USA. [Kunik, Mark E.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Kunik, Mark E.] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA. RP Kunik, ME (reprint author), Michael E DeBakey VAMC 152, Houston Ctr Qual Care & Utilizat Studies, 2002 Holcombe, Houston, TX 77030 USA. EM mkunik@bcm.tmc.edu RI Schueter, nicos/A-3625-2014 FU Houston Center for Quality of Care & Utilization Studies, Health Services Research and Development Service, Office of Research and Development, Department of Veterans Affairs [HFP90-020] FX This material is based on work supported in part by the Houston Center for Quality of Care & Utilization Studies, Health Services Research and Development Service, Office of Research and Development, Department of Veterans Affairs (HFP90-020).; The views expressed are those of the authors and do not necessarily reflect those of the VA or Baylor College of Medicine. NR 55 TC 47 Z9 48 U1 3 U2 16 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0895-0172 J9 J NEUROPSYCH CLIN N JI J. Neuropsychiatr. Clin. Neurosci. PD WIN PY 2011 VL 23 IS 1 BP 16 EP 28 DI 10.1176/appi.neuropsych.23.1.16 PG 13 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 717VY UT WOS:000287076700028 PM 21304135 ER PT J AU Gordon, AJ Ettaro, L Rodriguez, KL Mocik, J Clark, DB AF Gordon, Adam J. Ettaro, Lorraine Rodriguez, Keri L. Mocik, John Clark, Duncan B. TI Provider, Patient, and Family Perspectives of Adolescent Alcohol Use and Treatment in Rural Settings SO JOURNAL OF RURAL HEALTH LA English DT Article DE Access to care; adolescents; alcohol abuse; geography; patient assessment ID RANDOMIZED CONTROLLED-TRIAL; HIGH-RISK DRINKING; PRIMARY-CARE; BRIEF INTERVENTION; COLLEGE-STUDENTS; SUBSTANCE-ABUSE; USE DISORDERS; SCREENING-TEST; PREVENTION; BEHAVIORS AB Purpose: We examined rural primary care providers' (PCPs) self-reported practices of screening, brief interventions, and referral to treatment (SBIRT) on adolescent alcohol use and examined PCPs', adolescents', and parents' attitudes regarding SBIRT on adolescent alcohol use in rural clinic settings. Methods: In 2007, we mailed surveys that inquired about alcohol-related knowledge, attitudes, and treatment practices of adolescent alcohol use to all PCPs in 8 counties in rural Pennsylvania who may have treated adolescents. We then conducted 7 focus groups of PCPs and their staffs (n = 3), adolescents (n = 2), and parents (n = 2) and analyzed the narratives using structured grounded theory, evaluating for consistent or discordant themes. Results: Twenty-seven PCPs from 7 counties returned the survey. While 92% of PCPs felt that routine screening for alcohol use should begin by age 14, 84% reportedly screened for alcohol use occasionally, and reportedly 32% screened all adolescent patients. The provider focus groups (n = 20 PCPs/staff) related that SBIRT for alcohol use for adolescents was not currently effective. Poor provider training, lack of alcohol screening tools, and lack of referral treatment options were identified barriers. Adolescents (n = 12) worried that physicians would not maintain confidentiality. Parents (n = 12) acknowledged a parental contribution to adolescent alcohol use. All groups indicated computer-based methods to screen for alcohol use among adolescents may facilitate PCP engagement. Conclusions: Despite awareness that rural adolescent alcohol use is a significant problem, PCPs, adolescents, and parents recognize that SBIRT for adolescent alcohol use in rural PCP settings is ineffective, but it may improve with computer-based screening and intervention techniques. C1 [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Mental Illness Res Educ & Clincal Ctr, Pittsburgh, PA USA. [Gordon, Adam J.; Rodriguez, Keri L.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. [Gordon, Adam J.] Ctr Res Healthcare, Pittsburgh, PA USA. [Gordon, Adam J.; Ettaro, Lorraine; Mocik, John; Clark, Duncan B.] NW Penn Adolescent Alcohol Res Cooperat, Pittsburgh, PA USA. [Ettaro, Lorraine; Mocik, John] Univ Pittsburgh, Ctr Rural Hlth Practice, Bradford, PA USA. [Rodriguez, Keri L.] VA Pittsburgh Healthcare Syst, Ctr Geriatr Res Educ & Clin, Pittsburgh, PA USA. [Clark, Duncan B.] Pittsburgh Adolescent Alcohol Res Ctr, Pittsburgh, PA USA. [Gordon, Adam J.; Rodriguez, Keri L.; Clark, Duncan B.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. RP Gordon, AJ (reprint author), Mailcode 151-C-H,7180 Highland Dr, Pittsburgh, PA 15206 USA. EM adam.gordon@va.gov FU National Institutes of Health (NIH), National Institute of Alcohol Abuse and Alcoholism (NIAAA) [U01AA016482, K02AA00291] FX This study was supported by the National Institutes of Health (NIH), National Institute of Alcohol Abuse and Alcoholism (NIAAA) from grants U01AA016482 (PI: Clark) and K02AA00291 (PI: Clark). The authors wish to acknowledge Margaret Krumm, BA, for her assistance in editing this manuscript. The authors affirm that they have listed everyone who has contributed significantly to the work of this manuscript. For further information, contact: Adam J. Gordon, MD, MPH, FACP, FASAM, CHERP; Mailcode 151-C-H, 7180 Highland Drive, Pittsburgh, PA 15206; e-mail adam.gordon@va.gov. NR 45 TC 12 Z9 12 U1 2 U2 12 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0890-765X J9 J RURAL HEALTH JI J. Rural Health PD WIN PY 2011 VL 27 IS 1 BP 81 EP 90 DI 10.1111/j.1748-0361.2010.00321.x PG 10 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 702JZ UT WOS:000285891700010 PM 21204975 ER PT J AU DeLuca, DS Keskin, DB Zhang, GL Reinherz, EL Brusic, V AF DeLuca, David S. Keskin, Derin B. Zhang, Guang Lan Reinherz, Ellis L. Brusic, Vladimir TI PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments SO BMC BIOINFORMATICS LA English DT Article; Proceedings Paper CT 1st ISCB Asia Joint Conference on Computational Biology (InCoB/ISCB-Asia)/Asia Pacific Bioinformatics Network (APBioNet) 10th International Conference on Bioinformatics CY NOV 30-DEC 02, 2011 CL Kuala Lumpur, MALAYSIA SP ISCB, Asia Pacific Bioinformat Network (APBioNet) ID A VIRUS; PROTEIN AB Background: PB1-F2 is a major virulence factor of influenza A. This protein is a product of an alternative reading frame in the PB1-encoding RNA segment 2. Its presence of is dictated by the presence or absence of premature stop codons. This virulence factor is present in every influenza pandemic and major epidemic of the 20th century. Absence of PB1-F2 is associated with mild disease, such as the 2009 H1N1 ("swine flu"). Results: The analysis of 8608 segment 2 sequences showed that only 8.5% have been annotated for the presence of PB1-F2. Our analysis indicates that 75% of segment 2 sequences are likely to encode PB1-F2. Two major populations of PB1-F2 are of lengths 90 and 57 while minor populations include lengths 52, 63, 79, 81, 87, and 101. Additional possible populations include the lengths of 59, 69, 81, 95, and 106. Previously described sequences include only lengths 57, 87, and 90. We observed substantial variation in PB1-F2 sequences where certain variants show up to 35% difference to well-defined reference sequences. Therefore this dataset indicates that there are many more variants that need to be functionally characterized. Conclusions: Our web-accessible tool PB1-F2 Finder enables scanning of influenza sequences for potential PB1-F2 protein products. It provides an initial screen and annotation of PB1-F2 products. It is accessible at http://cvc.dfci.harvard.edu/pb1-f2. C1 [DeLuca, David S.; Keskin, Derin B.; Zhang, Guang Lan; Reinherz, Ellis L.; Brusic, Vladimir] Dana Farber Canc Inst, Canc Vaccine Ctr, Boston, MA 02115 USA. [DeLuca, David S.] Broad Inst, Cambridge, MA 02142 USA. RP Brusic, V (reprint author), Dana Farber Canc Inst, Canc Vaccine Ctr, 77 Ave Louis Pasteur, Boston, MA 02115 USA. EM vladimir_brusic@dfci.harvard.edu FU NIAID NIH HHS [U01 AI 90043, P30 AI060354] NR 10 TC 2 Z9 2 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD NOV 30 PY 2011 VL 12 SU 13 AR S6 DI 10.1186/1471-2105-12-S13-S6 PG 4 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 941AW UT WOS:000303935200006 PM 22373288 ER PT J AU Dohgu, S Fleegal-DeMotta, MA Banks, WA AF Dohgu, Shinya Fleegal-DeMotta, Melissa A. Banks, William A. TI Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF SO JOURNAL OF NEUROINFLAMMATION LA English DT Article DE Blood-brain barrier; Human immunodeficiency virus type 1; Lipopolysaccharide; Interleukin-6; Granulocyte-macrophage colony-stimulating factor; Mitogen-activated protein kinase ID TUMOR-NECROSIS-FACTOR; IMMUNODEFICIENCY-VIRUS-INFECTION; JUNCTION PROTEIN EXPRESSION; ENDOTHELIAL-CELLS; IN-VITRO; ADSORPTIVE ENDOCYTOSIS; SURFACE-PROTEINS; PERMEABILITY; CYTOKINES; ACTIVATION AB Elevated levels of cytokines/chemokines contribute to increased neuroinvasion of human immunodeficiency virus type 1 (HIV-1). Previous work showed that lipopolysaccharide (LPS), which is present in the plasma of patients with HIV-1, enhanced transcellular transport of HIV-1 across the blood-brain barrier (BBB) through the activation of p38 mitogen-activated protein kinase (MAPK) signaling in brain microvascular endothelial cells (BMECs). Here, we found that LPS (100 mu g/mL, 4 hr) selectively increased interleukin (IL)-6 and granulocyte-macrophage colony-stimulating factor (GM-CSF) release from BMECs. The enhancement of HIV-1 transport induced by luminal LPS was neutralized by treatment with luminal, but not with abluminal, antibodies to IL-6 and GM-CSF without affecting paracellular permeability as measured by transendothelial electrical resistance (TEER). Luminal, but not abluminal, IL-6 or GMCSF also increased HIV-1 transport. U0126 (MAPK kinase (MEK) 1/2 inhibitor) and SB203580 (p38 MAPK inhibitor) decreased the LPS-enhanced release of IL-6 and GM-CSF. These results show that p44/42 and p38 MAPK signaling pathways mediate the LPS-enhanced release of IL-6 and GM-CSF. These cytokines, in turn, act at the luminal surface of the BMEC to enhance the transcellular transport of HIV-1 independently of actions on paracellular permeability. C1 [Dohgu, Shinya; Fleegal-DeMotta, Melissa A.; Banks, William A.] Geriatr Res Educ & Clin Ctr St Louis, St Louis, MO USA. [Dohgu, Shinya] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmaceut Care & Hlth Sci, Fukuoka 81401, Japan. [Dohgu, Shinya; Fleegal-DeMotta, Melissa A.; Banks, William A.] St Louis Univ, Sch Med, Dept Internal Med, Div Geriatr Med, St Louis, MO 63103 USA. [Fleegal-DeMotta, Melissa A.] Clarke Univ, Dept Biol, Dubuque, IA USA. [Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA. [Banks, William A.] Univ Washington, Dept Internal Med, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA. RP Banks, WA (reprint author), Geriatr Res Educ & Clin Ctr St Louis, St Louis, MO USA. EM wabanks1@uw.edu FU National Cancer Institute, National Institutes of Health [N01-CO-12400]; VA Merit Review; NIH [R01NS050547, R01AG029839] FX The authors thank Dr. Maria A. Deli (Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences) for technical advice on primary BMEC culture and comments on this study. The virus was a kind gift the National Cancer Institute, National Institutes of Health. Funded in part with Federal funds from National Cancer Institute, National Institutes of Health, under Contract No. N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of names, commercial products, or organization imply endorsement by the U. S. government. Supported by VA Merit Review (WAB), NIH R01NS050547 (WAB), and NIH R01AG029839 (WAB). NR 53 TC 26 Z9 26 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD NOV 30 PY 2011 VL 8 AR 167 DI 10.1186/1742-2094-8-167 PG 12 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 878SK UT WOS:000299276600001 PM 22129063 ER PT J AU Folli, F Okada, T Perego, C Gunton, J Liew, CW Akiyama, M D'Amico, A La Rosa, S Placidi, C Lupi, R Marchetti, P Sesti, G Hellerstein, M Perego, L Kulkarni, RN AF Folli, Franco Okada, Terumasa Perego, Carla Gunton, Jenny Liew, Chong Wee Akiyama, Masaru D'Amico, Anna La Rosa, Stefano Placidi, Claudia Lupi, Roberto Marchetti, Piero Sesti, Giorgio Hellerstein, Marc Perego, Lucia Kulkarni, Rohit N. TI Altered Insulin Receptor Signalling and beta-Cell Cycle Dynamics in Type 2 Diabetes Mellitus SO PLOS ONE LA English DT Article ID HUMAN PANCREATIC-ISLETS; IN-VIVO; GENE-EXPRESSION; GROWTH-FACTOR; NUDE-MICE; APOPTOSIS; INHIBITORS; GLUCOSE; TRANSCRIPTION; REPLICATION AB Insulin resistance, reduced beta-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of islet cells. We observed reduced beta-cell mass and increased alpha-cell mass in the Type 2 diabetic pancreas. Confocal microscopy, real-time PCR and western blotting analyses revealed increased expression of PCNA and down-regulation of p27-Kip1 and altered expression of insulin receptors, insulin receptor substrate-2 and phosphorylated BAD. To investigate the mechanisms underlying these findings, we examined a mouse model of insulin resistance in beta-cells - which also exhibits reduced beta-cell mass, the beta-cell-specific insulin receptor knockout (beta IRKO). Freshly isolated islets and beta-cell lines derived from beta IRKO mice exhibited poor cell-cycle progression, nuclear restriction of FoxO1 and reduced expression of cell-cycle proteins favoring growth arrest. Re-expression of insulin receptors in beta IRKO beta-cells reversed the defects and promoted cell cycle progression and proliferation implying a role for insulin-signaling in beta-cell growth. These data provide evidence that human beta- and alpha-cells can enter the cell-cycle, but proliferation of beta-cells in T2DM fails due to G1-to-S phase arrest secondary to defective insulin signaling. Activation of insulin signaling, FoxO1 and proteins in beta-cell-cycle progression are attractive therapeutic targets to enhance beta-cell regeneration in the treatment of T2DM. C1 [Folli, Franco] Univ Texas Hlth Sci Ctr San Antonio, Div Diabet, Dept Med, San Antonio, TX 78229 USA. [Okada, Terumasa; Liew, Chong Wee; Akiyama, Masaru; Kulkarni, Rohit N.] Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02115 USA. [Okada, Terumasa; Liew, Chong Wee; Akiyama, Masaru; Kulkarni, Rohit N.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Perego, Carla; D'Amico, Anna; Perego, Lucia] Univ Milan, Dept Mol Sci Appl Biosyst, Milan, Italy. [Gunton, Jenny] Garvan Inst Med Res, Sydney, NSW, Australia. [La Rosa, Stefano; Placidi, Claudia] Univ Insubria, Dept Pathol, Osped Circolo, Varese, Italy. [La Rosa, Stefano; Placidi, Claudia] Univ Insubria, Dept Human Morphol, Varese, Italy. [Lupi, Roberto; Marchetti, Piero] Univ Pisa, Div Endocrinol, Pisa, Italy. [Sesti, Giorgio] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med, Catanzaro, Italy. [Hellerstein, Marc] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA. RP Folli, F (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Diabet, Dept Med, San Antonio, TX 78229 USA. EM folli@uthscsa.edu; Rohit.Kulkarni@joslin.harvard.edu RI Sesti, Giorgio/B-1509-2012; Gunton, Jenny/E-1561-2012; Marchetti, Piero/J-7439-2013; Perego, Carla/L-6147-2015; OI Marchetti, Piero/0000-0003-4907-0635; Perego, Carla/0000-0003-3027-1779; folli, franco/0000-0001-9824-5222 FU National Institutes of Health (NIH) [RO1 67536, 1-K99 DK090210-01]; National Health and Medical Research Council of Australia; Royal Australian College of Physicians; Ministero della Salute; MIUR; University of Milano, School of Medicine; Sunstar Fellowship FX This study was supported by grants from the National Institutes of Health (NIH) RO1 67536 (RNK). JG was supported by a C.J. Martin Fellowship from the National Health and Medical Research Council of Australia and Royal Australian College of Physicians Servier Award. FF was supported by Ministero della Salute and MIUR. LP was supported by a postdoctoral fellowship from the University of Milano, School of Medicine. CWL was supported by NIH 1-K99 DK090210-01, and MA is supported by a Sunstar Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 59 TC 34 Z9 35 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 30 PY 2011 VL 6 IS 11 AR e28050 DI 10.1371/journal.pone.0028050 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863MI UT WOS:000298168100032 PM 22140505 ER PT J AU Li, CG Fang, R Sun, YH Han, XK Li, F Gao, B Iafrate, AJ Liu, XY Pao, W Chen, HQ Ji, HB AF Li, Chenguang Fang, Rong Sun, Yihua Han, Xiangkun Li, Fei Gao, Bin Iafrate, A. John Liu, Xin-Yuan Pao, William Chen, Haiquan Ji, Hongbin TI Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers SO PLOS ONE LA English DT Article ID CANCER STATISTICS; EGFR; DIAGNOSIS; SURVIVAL; KINASES; FUSION; TRIAL AB Purpose: We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) of lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. Here, we sought to extend these findings to more samples and identify driver alterations in tumors negative for these mutations. Experimental Design: We have collected and analyzed 202 resected lung adenocarcinomas from never smokers seen at Fudan University Shanghai Cancer Center. Since mutations were mutually exclusive in the first 52 examined, we determined the status of EGFR, KRAS, HER2, ALK, and BRAF in stepwise fashion as previously described. Samples negative for mutations in these 5 genes were subsequently examined for known ROS1 fusions by RT-PCR and direct sequencing. Results: 152 tumors (75.3%) harbored EGFR mutations, 12 (6%) had HER2 mutations, 10 (5%) had ALK fusions all involving EML4 as the 59 partner, 4 (2%) had KRAS mutations, and 2 (1%) harbored ROS1 fusions. No BRAF mutation were detected. Conclusion: The vast majority (176 of 202; 87.1%, 95% CI: 0.82 to 0.91) of lung adenocarcinomas from never smokers harbor mutant kinases sensitive to available TKIs. Interestingly, patients with EGFR mutant patients tend to be older than those without EGFR mutations (58.3 Vs 54.3, P = 0.016) and patient without any known oncogenic driver tend to be diagnosed at a younger age (52.3 Vs 57.9, P = 0.013). Collectively, these data indicate that the majority of never smokers with lung adenocarcinoma could benefit from treatment with a specific tyrosine kinase inhibitor. C1 [Li, Chenguang; Fang, Rong; Han, Xiangkun; Li, Fei; Gao, Bin; Liu, Xin-Yuan; Ji, Hongbin] Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China. [Li, Chenguang; Sun, Yihua; Chen, Haiquan] Fudan Univ, Dept Thorac Surg, Shanghai Canc Ctr, Shanghai 200433, Peoples R China. [Li, Chenguang; Sun, Yihua; Chen, Haiquan] Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China. [Iafrate, A. John] Massachusetts Gen Hosp, Dept Pathol, Ctr Canc, Boston, MA 02114 USA. [Pao, William] Vanderbilt Ingram Canc Ctr, Nashville, TN USA. RP Li, CG (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China. EM william.pao@vanderbilt.edu; hqchen1@yahoo.com; hbji@sibs.ac.cn FU National Basic Research Program of China [2010CB912102, 2012CB910800]; National Natural Science Foundation of China [30871284, 30971461]; Chinese Academy of Sciences [2010KIP504]; Science and Technology Commission of Shanghai Municipality [09JC1416300]; National Cancer Institute (USA) [R01 CA121210]; Specialized Program of Research Excellence in Lung Cancer [CA90949]; Vanderbilt-Ingram Cancer Center [CA68485]; Xcovery FX This work was supported by the National Basic Research Program of China (2010CB912102; 2012CB910800), the National Natural Science Foundation of China (30871284 and 30971461), the Chinese Academy of Sciences (2010KIP504), and the Science and Technology Commission of Shanghai Municipality (09JC1416300). H.J. is a scholar of the Hundred Talents Program of the Chinese Academy of Sciences. W. P. received funding from the National Cancer Institute (USA): R01 CA121210; the Specialized Program of Research Excellence in Lung Cancer Grant (CA90949), and the Vanderbilt-Ingram Cancer Center Core Grant (CA68485). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; The authors have read the journal's policy and have the following conflicts: Dr. William Pao has consulted for AstraZeneca and MolecularMD and has received research funding from Xcovery. Dr. A. John Iafrate has consulted for Pfizer and Abbott Molecular. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. NR 20 TC 96 Z9 104 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 30 PY 2011 VL 6 IS 11 AR e28204 DI 10.1371/journal.pone.0028204 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863MI UT WOS:000298168100050 PM 22140546 ER PT J AU Zhang, GL Ansari, HR Bradley, P Cawley, GC Hertz, T Hu, XH Jojic, N Kim, Y Kohlbacher, O Lund, O Lundegaard, C Magaret, CA Nielsen, M Papadopoulos, H Raghava, GPS Tal, VS Xue, LC Yanover, C Zhu, SF Rock, MT Crowe, JE Panayiotou, C Polycarpou, MM Duch, W Brusic, V AF Zhang, Guang Lan Ansari, Hifzur Rahman Bradley, Phil Cawley, Gavin C. Hertz, Tomer Hu, Xihao Jojic, Nebojsa Kim, Yohan Kohlbacher, Oliver Lund, Ole Lundegaard, Claus Magaret, Craig A. Nielsen, Morten Papadopoulos, Harris Raghava, G. P. S. Tal, Vider-Shalit Xue, Li C. Yanover, Chen Zhu, Shanfeng Rock, Michael T. Crowe, James E. Panayiotou, Christos Polycarpou, Marios M. Duch, Wlodzislaw Brusic, Vladimir TI Machine learning competition in immunology - Prediction of HLA class I binding peptides SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Editorial Material DE Computational models; HLA; Human leukocyte antigen; Machine learning; Peptide binding; Predictions ID T-CELL EPITOPES; IDENTIFICATION; DATABASE; SYSTEM C1 [Zhang, Guang Lan; Brusic, Vladimir] Dana Farber Canc Inst, CVC, Boston, MA 02115 USA. [Ansari, Hifzur Rahman; Raghava, G. P. S.] Inst Microbial Technol, Chandigarh, India. [Bradley, Phil; Hertz, Tomer; Magaret, Craig A.; Yanover, Chen] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Cawley, Gavin C.] Univ E Anglia, Norwich NR4 7TJ, Norfolk, England. [Hu, Xihao; Zhu, Shanfeng] Fudan Univ, Shanghai 200433, Peoples R China. [Jojic, Nebojsa] Microsoft Res, Redmond, WA USA. [Kim, Yohan] La Jolla Inst Allergy & Immunol, La Jolla, CA USA. [Kohlbacher, Oliver] Univ Tubingen, Tubingen, Germany. [Lund, Ole; Lundegaard, Claus; Nielsen, Morten] Danish Tech Univ, CBS, Lyngby, Denmark. [Papadopoulos, Harris] Frederick Univ, Nicosia, Cyprus. [Tal, Vider-Shalit] Bar Ilan Univ, Ramat Gan, Israel. [Xue, Li C.] Iowa State Univ, Ames, IA USA. [Rock, Michael T.; Crowe, James E.] Vanderbilt Univ, Nashville, TN USA. [Panayiotou, Christos; Polycarpou, Marios M.] Univ Cyprus, Nicosia, Cyprus. [Duch, Wlodzislaw] Nanyang Technol Univ, SCE, Singapore, Singapore. [Duch, Wlodzislaw] Nicholas Copernicus Univ, Torun, Poland. RP Brusic, V (reprint author), Dana Farber Canc Inst, CVC, Boston, MA 02115 USA. EM vladimir_brusic@dfci.harvard.edu RI Lundegaard, Claus/B-3938-2012; Yanover, Chen/A-3754-2012; Duch, Wlodzislaw/A-2002-2011; Kohlbacher, Oliver/B-7310-2008; Papadopoulos, Harris/A-4990-2013; Crowe, James/B-5549-2009; Lund, Ole/F-4437-2014; Nielsen, Morten/E-7754-2011; Raghava, Gajendra/B-1717-2009; Hertz, Tomer/S-5744-2016 OI Raghava, Gajendra/0000-0002-8902-2876; Panayiotou, Christos/0000-0002-6476-9025; Yanover, Chen/0000-0003-3663-4286; Duch, Wlodzislaw/0000-0001-7882-4729; Ansari, Hifzur Rahman/0000-0002-0646-1743; Kohlbacher, Oliver/0000-0003-1739-4598; Papadopoulos, Harris/0000-0002-6839-6940; Crowe, James/0000-0002-0049-1079; Lund, Ole/0000-0003-1108-0491; Nielsen, Morten/0000-0001-7885-4311; Hertz, Tomer/0000-0002-0561-1578 NR 13 TC 28 Z9 28 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD NOV 30 PY 2011 VL 374 IS 1-2 SI SI BP 1 EP 4 DI 10.1016/j.jim.2011.09.010 PG 4 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA 864DP UT WOS:000298217500001 PM 21986107 ER PT J AU Zhang, GL Lin, HH Keskin, DB Reinherz, EL Brusic, V AF Zhang, Guang Lan Lin, Hong Huang Keskin, Derin B. Reinherz, Ellis L. Brusic, Vladimir TI Dana-Farber repository for machine learning in immunology SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE HLA binding; Prediction; Mathematical model; Data repository; Immune system; T cell epitope ID MAJOR HISTOCOMPATIBILITY COMPLEX; PEPTIDE BINDING PREDICTION; CLASS-II MHC; HLA-DR; COMPUTATIONAL SYSTEM; RESTRICTED EPITOPES; VACCINE DEVELOPMENT; T-CELLS; MOLECULES; GENOMICS AB The immune system is characterized by high combinatorial complexity that necessitates the use of specialized computational tools for analysis of immunological data. Machine learning (ML) algorithms are used in combination with classical experimentation for the selection of vaccine targets and in computational simulations that reduce the number of necessary experiments. The development of ML algorithms requires standardized data sets, consistent measurement methods, and uniform scales. To bridge the gap between the immunology community and the ML community, we designed a repository for machine learning in immunology named Dana-Farber Repository for Machine Learning in Immunology (DFRMLI). This repository provides standardized data sets of HLA-binding peptides with all binding affinities mapped onto a common scale. It also provides a list of experimentally validated naturally processed T cell epitopes derived from tumor or virus antigens. The DFRMLI data were preprocessed and ensure consistency, comparability, detailed descriptions, and statistically meaningful sample sizes for peptides that bind to various HLA molecules. The repository is accessible at http://bio.dfci.harvard.edu/DFRMLI/. (C) 2011 Elsevier B.V. All rights reserved. C1 [Zhang, Guang Lan; Lin, Hong Huang; Keskin, Derin B.; Reinherz, Ellis L.; Brusic, Vladimir] Dana Farber Canc Inst, Canc Vaccine Ctr, Boston, MA 02115 USA. RP Brusic, V (reprint author), Dana Farber Canc Inst, Canc Vaccine Ctr, Boston, MA 02115 USA. EM vladimir_brusic@dfci.harvard.edu OI Lin, Honghuang/0000-0003-3043-3942 FU NIH [U19AI57330, 470 U01AI90043]; DOD [W81XWH-07-1-0080] FX This work was supported by NIH grants U19AI57330 and 470 U01AI90043 and a grant from DOD W81XWH-07-1-0080. We are thankful to Dr Songsak Tongchusak for providing a list of T cell epitopes that was included in DFRMLI and Tara C. Mayo for thoughtful review of the manuscript. NR 58 TC 13 Z9 13 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD NOV 30 PY 2011 VL 374 IS 1-2 SI SI BP 18 EP 25 DI 10.1016/j.jim.2011.07.007 PG 8 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA 864DP UT WOS:000298217500004 PM 21782820 ER PT J AU Zhang, GL DeLuca, DS Keskin, DB Chitkushev, L Zlateva, T Lund, O Reinherz, EL Brusic, V AF Zhang, Guang Lan DeLuca, David S. Keskin, Derin B. Chitkushev, Lou Zlateva, Tanya Lund, Ole Reinherz, Ellis L. Brusic, Vladimir TI MULTIPRED2: A computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE T-cell epitope hotspots; HLA; HLA supertype; Human leukocyte antigen; Promiscuous binding peptide; Vaccine design ID CLASS-I SUPERTYPES; VACCINE DEVELOPMENT; HIV ENVELOPE; PROTEIN; POLYMORPHISM; MOLECULES; HOTSPOTS; SERVERS; REGIONS; ANTIGEN AB MULTIPRED2 is a computational system for facile prediction of peptide binding to multiple alleles belonging to human leukocyte antigen (HLA) class land class II DR molecules. It enables prediction of peptide binding to products of individual HLA alleles, combination of alleles, or HLA supertypes. NetMHCpan and NetMHCIIpan are used as prediction engines. The 13 HLA Class I supertypes are A1, A2, A3, A24, B7, B8, B27, B44, B58, B62, C1, and C4. The 13 HLA Class II DR supertypes are DR1, DR3, DR4, DR6, DR7, DR8, DR9, DR11, DR12, DR13, DR14, DR15, and DR16. In total, MULTIPRED2 enables prediction of peptide binding to 1077 variants representing 26 HLA supertypes. MULTIPRED2 has visualization modules for mapping promiscuous T-cell epitopes as well as those regions of high target concentration - referred to as T-cell epitope hotspots. Novel graphic representations are employed to display the predicted binding peptides and immunological hotspots in an intuitive manner and also to provide a global view of results as heat maps. Another function of MULTIPRED2, which has direct relevance to vaccine design, is the calculation of population coverage. Currently it calculates population coverage in five major groups in North America. MULTIPRED2 is an important tool to complement wet-lab experimental methods for identification of T-cell epitopes. It is available at http://cvc.dfci.harvard.edu/multipred2/. (C) 2010 Elsevier By. All rights reserved. C1 [Zhang, Guang Lan; DeLuca, David S.; Keskin, Derin B.; Reinherz, Ellis L.; Brusic, Vladimir] Harvard Univ, Sch Med, Dana Farber Canc Inst, Canc Vaccine Ctr, Boston, MA 02115 USA. [Chitkushev, Lou; Zlateva, Tanya] Boston Univ, Dept Comp Sci, Metropolitan Coll, Boston, MA 02215 USA. [Lund, Ole] Tech Univ Denmark, Ctr Biol Sequence Anal, Dept Syst Biol, DK-2800 Lyngby, Denmark. RP Zhang, GL (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Canc Vaccine Ctr, 44 Binney St, Boston, MA 02115 USA. EM guanglan_zhang@dfci.harvard.edu RI Lund, Ole/F-4437-2014 OI Lund, Ole/0000-0003-1108-0491 FU NIH [U19 AI 57330, U01 AI 90043]; DOD [W81XWH-07-1-0080] FX This work was supported by NIH grants U19 AI 57330 and U01 AI 90043 and a grant from DOD W81XWH-07-1-0080. NR 33 TC 22 Z9 22 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD NOV 30 PY 2011 VL 374 IS 1-2 SI SI BP 53 EP 61 DI 10.1016/j.jim.2010.11.009 PG 9 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA 864DP UT WOS:000298217500009 PM 21130094 ER PT J AU Von Roenn, JH Temel, J AF Von Roenn, Jamie H. Temel, Jennifer TI The Integration of Palliative Care and Oncology: the Evidence SO ONCOLOGY-NEW YORK LA English DT Review ID CELL LUNG-CANCER; QUALITY-OF-LIFE; RANDOMIZED-TRIAL; SUPPORTIVE CARE; ELDERLY-PATIENTS; PHASE-III; CHEMOTHERAPY; PLUS; GEMCITABINE; VINORELBINE AB Cancer care and palliative care each require a complex multi- and interdisciplinary approach to maximize the care of people with cancer. Recommendations for cancer treatment should both relieve the symptoms of cancer and prevent and treat side effects of anticancer therapy. Unrelieved symptoms not only contribute to worse quality of life but also can reduce a patient's ability to tolerate cancer therapy and may have a negative impact on survival. Consistent integration of palliative care practices into standard oncology care is needed across the trajectory of the cancer experience. This article will review the overlap between palliative care and oncology and discuss the available evidence that true integration of palliative and oncology care provides patients with optimal oncology care. C1 [Von Roenn, Jamie H.] Northwestern Univ, NW Mem Hosp, Home Hosp Program, Feinberg Sch Med, Chicago, IL 60611 USA. [Von Roenn, Jamie H.] Northwestern Univ, NW Mem Hosp, Home Hosp Program, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. [Temel, Jennifer] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. RP Von Roenn, JH (reprint author), Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, 676 N St Clair St,Suite 850, Chicago, IL 60611 USA. EM j-vonroenn@northwestern.edu NR 25 TC 12 Z9 12 U1 0 U2 1 PU UBM MEDICA PI NORWALK PA 535 CONNECTICUT AVE, STE 300, NORWALK, CT 06854 USA SN 0890-9091 J9 ONCOLOGY-NY JI Oncology-NY PD NOV 30 PY 2011 VL 25 IS 13 SI SI BP 1258 EP + PG 6 WC Oncology SC Oncology GA 861KW UT WOS:000298018800002 PM 22272492 ER PT J AU Sperling, RA Jack, CR Aisen, PS AF Sperling, Reisa A. Jack, Clifford R., Jr. Aisen, Paul S. TI Testing the Right Target and Right Drug at the Right Stage SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; AMYLOID DEPOSITION; A-BETA; CSF BIOMARKERS; OLDER-ADULTS; ASSOCIATION; MRI; RECOMMENDATIONS; IMMUNIZATION AB Alzheimer's disease (AD) is the only leading cause of death for which no disease-modifying therapy is currently available. Recent disappointing trial results at the dementia stage of AD have raised multiple questions about our current approaches to the development of disease-modifying agents. Converging evidence suggests that the pathophysiological process of AD begins many years before the onset of dementia. So why do we keep testing drugs aimed at the initial stages of the disease process in patients at the end-stage of the illness? C1 [Sperling, Reisa A.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Alzheimer Res & Treatment,Brigham & Womens Ho, Boston, MA 02446 USA. [Jack, Clifford R., Jr.] Mayo Clin, Dept Radiol, Rochester, MN 55902 USA. [Aisen, Paul S.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA. RP Sperling, RA (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Alzheimer Res & Treatment,Brigham & Womens Ho, Boston, MA 02446 USA. EM reisa@rics.bwh.harvard.edu RI Jack, Clifford/F-2508-2010 OI Jack, Clifford/0000-0001-7916-622X FU Baxter; Pfizer; Baxter International FX We acknowledge the thoughtful comments from our colleagues on early drafts of this manuscript, including K. Johnson, D. Rentz, and all of the researchers who have contributed to the scientific evidence discussed in this perspective. Competing interests. R. A. S. has served as a site investigator and/or consultant for Pfizer, Janssen, Bristol-Myers-Squibb, Elan, Bayer, Avid, Roche, Eli Lilly, Biogen/IDEC, and Eisai. C.R.J. has served as a consultant for Eli Lilly, Eisai, and Elan; is an investigator in clinical trials sponsored by Baxter and Pfizer; and owns stock in Johnson and Johnson. P. S. A. serves on a scientific advisory board for NeuroPhage; serves as a consultant to Elan Corporation, Wyeth, Eisai, Bristol-Myers Squibb, Eli Lilly and Company, NeuroPhage, Merck & Co., Roche, Amgen, Abbott, Pfizer, Novartis, Bayer, Astellas, Dainippon, Biomarin, Solvay, Otsuka, Daiichi, AstraZeneca, Janssen, and Medivation; receives research support from Pfizer and Baxter International; and has received stock options from Medivation and NeuroPhage. NR 36 TC 63 Z9 66 U1 0 U2 4 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 J9 SCI TRANSL MED JI Sci. Transl. Med. PD NOV 30 PY 2011 VL 3 IS 111 AR 111cm33 DI 10.1126/scitranslmed.3002609 PG 5 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA 862GX UT WOS:000298079000001 PM 22133718 ER PT J AU Candidi, M Stienen, BMC Aglioti, SM de Gelder, B AF Candidi, Matteo Stienen, Bernard M. C. Aglioti, Salvatore Maria de Gelder, Beatrice TI Event-Related Repetitive Transcranial Magnetic Stimulation of Posterior Superior Temporal Sulcus Improves the Detection of Threatening Postural Changes in Human Bodies SO JOURNAL OF NEUROSCIENCE LA English DT Article ID EXTRASTRIATE BODY AREA; VISUAL CORTICAL ACTIVATION; VENTRAL PREMOTOR CORTEX; SHORT-TERM-MEMORY; BIOLOGICAL MOTION; STATE-DEPENDENCY; EMOTIONAL MODULATION; SOCIAL-PERCEPTION; NEURAL MECHANISMS; NEURONAL-ACTIVITY AB Perceiving others' emotions through their body movements and postures is crucial for successful social interaction. While imaging studies indicate that perceiving body emotions relies upon a wide network of subcortico-cortical neural regions, little is known on the causative role of different nodes of this network. We applied event-related repetitive transcranial magnetic stimulation (rTMS) over nonfacial, body-and action-related extrastriate (EBA), temporal (pSTS), and premotor (vPM) cortices to test their active contribution in perceiving changes between two successive images of either threatening or neutral human body or animal postures. While stimulation of EBA and vPM showed no selective effect on threatening stimuli with respect to neutral ones, rTMS over pSTS selectively impaired neutral posture detection and increased the accuracy in detecting changes of threatening human postures with respect to all other experimental conditions. No such effect was found for animal stimuli. These results support the notion that pSTS is crucially devoted to the detection of socially relevant information concerning others' actions, fostering the notion that amygdalo-temporo-cortical modulatory connections mediate perception of emotionally salient body postures. C1 [Candidi, Matteo; Aglioti, Salvatore Maria] Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy. [Candidi, Matteo; Aglioti, Salvatore Maria] Fdn Santa Lucia, IRCCS, I-00179 Rome, Italy. [Stienen, Bernard M. C.; de Gelder, Beatrice] Tilburg Univ, Cognit & Affect Neurosci Lab, NL-5000 LE Tilburg, Netherlands. [de Gelder, Beatrice] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA. [de Gelder, Beatrice] Harvard Univ, Sch Med, Charlestown, MA 02129 USA. RP Candidi, M (reprint author), Univ Roma La Sapienza, Dept Psychol, Via Marsi 78,POB 00185, I-00185 Rome, Italy. EM matteo.candidi@uniroma1.it FU Istituto Italiano di Tecnologia SEED [21538]; Italian Ministry of Health; European FP7 Grant Tango; The Netherlands Organisation for Scientific Research; Tango; European Commission [249858] FX S.M.A. was funded by the Istituto Italiano di Tecnologia SEED (Prot. Num. 21538), the Italian Ministry of Health, and the European FP7 Grant Tango. B.d.G. was funded by The Netherlands Organisation for Scientific Research and by Tango. The project Tango acknowledges the financial support of the Future and Emerging Technologies (FET) program within the Seventh Framework Programme for Research of the European Commission, under FET-Open Grant number 249858. NR 80 TC 21 Z9 22 U1 0 U2 8 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD NOV 30 PY 2011 VL 31 IS 48 BP 17547 EP 17554 DI 10.1523/JNEUROSCI.0697-11.2011 PG 8 WC Neurosciences SC Neurosciences & Neurology GA 860FY UT WOS:000297935400022 PM 22131416 ER PT J AU Putcha, D Brickhouse, M O'Keefe, K Sullivan, C Rentz, D Marshall, G Dickerson, B Sperling, R AF Putcha, Deepti Brickhouse, Michael O'Keefe, Kelly Sullivan, Caroline Rentz, Dorene Marshall, Gad Dickerson, Brad Sperling, Reisa TI Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults SO JOURNAL OF NEUROSCIENCE LA English DT Article ID MILD COGNITIVE IMPAIRMENT; DEFAULT MODE NETWORK; FUNCTIONAL CONNECTIVITY; AD DEMENTIA; AMYLOID DEPOSITION; ENTORHINAL CORTEX; BRAIN ACTIVITY; OLDER-ADULTS; MEMORY; ACTIVATION AB Alzheimer's disease (AD) is associated with functional and structural alterations in a distributed network of brain regions supporting memory and other cognitive domains. Functional abnormalities are present in mild cognitive impairment (MCI) with evidence of early hyperactivity in medial temporal lobe regions, followed by failure of hippocampal activation as dementia develops. Atrophy in a consistent set of cortical regions, the "cortical signature of AD," has been reported at the stage of dementia, MCI, and even in clinically normal (CN) older individuals predicted to develop AD. Despite multiple lines of evidence for each of these findings, the relationship between this structural marker of AD-related neurodegeneration and this functional marker of the integrity of the episodic memory system has not yet been elucidated. We investigated this relationship in 34 nondemented older humans (CN, N = 18; MCI, N = 16). Consistent with previous studies, we found evidence of hippocampal hyperactivation in MCI compared with CN. Additionally, within this MCI group, increased hippocampal activation correlated with cortical thinning in AD-signature regions. Even within the CN group, increased hippocampal activity was negatively correlated with cortical thinning in a subset of regions, including the superior parietal lobule (r = -0.66; p < 0.01). These findings, across a continuum of nondemented and mildly impaired older adults, support the hypothesis that paradoxically increased hippocampal activity may be an early indicator of AD-related neurodegeneration in a distributed network. C1 [Putcha, Deepti; O'Keefe, Kelly; Sullivan, Caroline; Rentz, Dorene; Marshall, Gad; Sperling, Reisa] Harvard Univ, Ctr Alzheimer Res & Treatment, Brigham & Womens Hosp, Dept Neurol,Med Sch, Boston, MA 02115 USA. [Putcha, Deepti; Brickhouse, Michael; O'Keefe, Kelly; Sullivan, Caroline; Rentz, Dorene; Marshall, Gad; Dickerson, Brad; Sperling, Reisa] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Putcha, Deepti; Brickhouse, Michael; O'Keefe, Kelly; Sullivan, Caroline; Rentz, Dorene; Marshall, Gad; Dickerson, Brad; Sperling, Reisa] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02114 USA. RP Sperling, R (reprint author), Harvard Univ, Ctr Alzheimer Res & Treatment, Brigham & Womens Hosp, Dept Neurol,Med Sch, 221 Longwood Ave, Boston, MA 02115 USA. EM reisa@rics.bwh.harvard.edu FU National Institute on Aging [R01 AG-027435, P01 AG036694, K23 AG027171, P50 AG005134] FX This work was supported by the National Institute on Aging Grants R01 AG-027435, P01 AG036694, K23 AG027171, and P50 AG005134. We gratefully acknowledge Mary Foley, Larry White, and the Athinoula A. Martinos Center for Biomedical Imaging for assistance with scan acquisition. We are also grateful for the participation of our research subjects. NR 61 TC 71 Z9 71 U1 1 U2 16 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD NOV 30 PY 2011 VL 31 IS 48 BP 17680 EP 17688 DI 10.1523/JNEUROSCI.4740-11.2011 PG 9 WC Neurosciences SC Neurosciences & Neurology GA 860FY UT WOS:000297935400034 PM 22131428 ER PT J AU Schurpf, T Springer, TA AF Schuerpf, Thomas Springer, Timothy A. TI Regulation of integrin affinity on cell surfaces SO EMBO JOURNAL LA English DT Article DE ICAM-1; CD11a/CD18; lymphocyte function-associated antigen-1 (LFA-1); metal ion-dependent adhesion site (MIDAS); stromal cell-derived factor (SDF) ID FUNCTION-ASSOCIATED ANTIGEN-1; ADHESION MOLECULE-1 ICAM-1; I-LIKE DOMAIN; T-CELL; STRUCTURAL BASIS; CYTOPLASMIC DOMAIN; CRYSTAL-STRUCTURE; EXTENDED CONFORMATIONS; IMMUNOLOGICAL SYNAPSE; MONOCLONAL-ANTIBODY AB Lymphocyte activation triggers adhesiveness of lymphocyte function-associated antigen-1 (LFA-1; integrin alpha(L)beta(2)) for intercellular adhesion molecules (ICAMs) on endothelia or antigen-presenting cells. Whether the activation signal, after transmission through multiple domains to the ligand-binding alpha I domain, results in affinity changes for ligand has been hotly debated. Here, we present the first comprehensive measurements of LFA-1 affinities on T lymphocytes for ICAM-1 under a broad array of activating conditions. Only a modest increase in affinity for soluble ligand was detected after activation by chemokine or T-cell receptor ligation, conditions that primed LFA-1 and robustly induced lymphocyte adhesion to ICAM-1 substrates. By stabilizing well-defined LFA-1 conformations by Fab, we demonstrate the absolute requirement of the open LFA-1 headpiece for adhesiveness and high affinity. Interaction of primed LFA-1 with immobilized but not soluble ICAM-1 triggers energy-dependent affinity maturation of LFA-1 to an adhesive, high affinity state. Our results lend support to the traction or translational motion dependence of integrin activation. The EMBO Journal (2011) 30, 4712-4727. doi:10.1038/emboj.2011.333; Published online 23 September 2011 C1 [Springer, Timothy A.] Harvard Univ, Sch Med, Dept Pathol, Immune Dis Inst, Boston, MA 02115 USA. [Springer, Timothy A.] Childrens Hosp, Boston, MA 02115 USA. RP Springer, TA (reprint author), Harvard Univ, Sch Med, Dept Pathol, Immune Dis Inst, 3 Blackfan Circle, Boston, MA 02115 USA. EM springer@idi.harvard.edu RI Schurpf, Thomas/E-7380-2012 FU NIH [CA31798]; Swiss National Science Foundation FX This work was supported by NIH Grant CA31798 and a fellowship from the Swiss National Science Foundation. We thank Dr M Robinson (Celltech, Slough, UK), Dr Nancy Hogg (Imperial Cancer Research Fund, London, UK), and Dr V Horejsi (Institute of Molecular Genetics, Prague) for providing KIM127, m24, and MEM148 antibodies, respectively. We acknowledge Dr Terence Kelly (Boehringer Ingelheim, Ridgeway, CT), Dr Paul Gillespie (Roche, Nutley, NJ), and Genentech (South San Francisco, CA) for providing BIRT377, XVA143, and compound #4, respectively. The expression vector pLEXm was obtained from Dr Y Jones, Oxford, UK. We thank Drs Xing Chen and Yamei Yu for help with Fab fragmentation, and Drs Chafen Lu and Motomu Shimaoka for critically reading the manuscript. NR 75 TC 55 Z9 57 U1 0 U2 7 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0261-4189 J9 EMBO J JI Embo J. PD NOV 30 PY 2011 VL 30 IS 23 BP 4712 EP 4727 DI 10.1038/emboj.2011.333 PG 16 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 857CO UT WOS:000297692100005 PM 21946563 ER PT J AU Ohki, Y Higo, T Uemura, K Shimada, N Osawa, S Berezovska, O Yokoshima, S Fukuyama, T Tomita, T Iwatsubo, T AF Ohki, Yu Higo, Takuya Uemura, Kengo Shimada, Naoaki Osawa, Satoko Berezovska, Oksana Yokoshima, Satoshi Fukuyama, Tohru Tomita, Taisuke Iwatsubo, Takeshi TI Phenylpiperidine-type gamma-secretase modulators target the transmembrane domain 1 of presenilin 1 SO EMBO JOURNAL LA English DT Article DE Alzheimer; modulation; protease; secretase ID AMYLOID-BETA-PROTEIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CARBOXYL-TERMINAL FRAGMENT; ALZHEIMER-DISEASE; CATALYTIC PORE; A-BETA; A-BETA-42; PEPTIDE; COMPLEX; OVERPRODUCTION AB Amyloid-beta peptide ending at the 42nd residue (A beta 42) is implicated in the pathogenesis of Alzheimer's disease (AD). Small compounds that exhibit selective lowering effects on A beta 42 production are termed gamma-secretase modulators (GSMs) and are deemed as promising therapeutic agents against AD, although the molecular target as well as the mechanism of action remains controversial. Here, we show that a phenylpiperidine-type compound GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1) by photoaffinity labelling experiments combined with limited digestion. Binding of GSM-1 affected the structure of the initial substrate binding and the catalytic sites of the gamma-secretase, thereby decreasing production of A beta 42, possibly by enhancing its conversion to A beta 38. These data indicate an allosteric action of GSM-1 by directly binding to the TMD1 of PS1, pinpointing the target structure of the phenylpiperidine-type GSMs. The EMBO Journal (2011) 30, 4815-4824. doi:10.1038/emboj.2011.372; Published online 14 October 2011 C1 [Tomita, Taisuke; Iwatsubo, Takeshi] Univ Tokyo, Dept Neuropathol & Neurosci, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan. [Higo, Takuya; Shimada, Naoaki; Yokoshima, Satoshi; Fukuyama, Tohru] Univ Tokyo, Dept Synthet Nat Prod Chem, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan. [Uemura, Kengo; Berezovska, Oksana] Massachusetts Gen Hosp, MassGen Inst Neurodegenerat Dis, Alzheimer Res Unit, Charlestown, MA USA. [Tomita, Taisuke; Iwatsubo, Takeshi] Japan Sci & Technology Corp, Core Res Evolut Sci & Technol, Tokyo, Japan. [Iwatsubo, Takeshi] Univ Tokyo, Dept Neuropathol, Grad Sch Med, Tokyo 1130033, Japan. RP Tomita, T (reprint author), Univ Tokyo, Dept Neuropathol & Neurosci, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan. EM taisuke@mol.f.u-tokyo.ac.jp; iwatsubo@m.u-tokyo.ac.jp RI Tomita, Taisuke/L-5427-2015; Yokoshima, Satoshi/I-6961-2014 OI Tomita, Taisuke/0000-0002-0075-5943; Yokoshima, Satoshi/0000-0003-4036-0062 FU Japan Society for the Promotion of Science (JSPS); Ministry of Education, Culture, Sports, Science and Technology, Japan; National Institute of Biomedical Innovation; Japan Science and Technology Corporation (JST); Core Research for Evolutional Science and Technology of JST, Japan; NIH [AG15379] FX We are grateful to Drs R Kopan (Washington University in St Louis), G Thinakaran (The University of Chicago), T Golde (University of Florida), B De Strooper (VIB Leuven), H Fuwa (Tohoku University) and Y Li (Sloan-Kettering Cancer Center), T Kitamura (The University of Tokyo), S Funamoto and Y Ihara (Doshisha University) for valuable reagents, Takeda pharmaceutical company for Ab ELISA, and our current and previous laboratory members for helpful discussions and technical assistance. This work was supported in part by grants-in-aid for Young Scientists (S) from the Japan Society for the Promotion of Science (JSPS) (TT), Scientific Research on Priority Areas Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology, Japan (TT and TI), by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (TT and TI), by Targeted Proteins Research Program of the Japan Science and Technology Corporation (JST) (SY, TF, TTand TI), by Core Research for Evolutional Science and Technology of JST (SY, TF, TT and TI), Japan, and by NIH AG15379 (OB). YO and TH are research fellows of JSPS. NR 43 TC 61 Z9 62 U1 0 U2 6 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0261-4189 J9 EMBO J JI Embo J. PD NOV 30 PY 2011 VL 30 IS 23 BP 4815 EP 4824 DI 10.1038/emboj.2011.372 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 857CO UT WOS:000297692100013 PM 22002539 ER PT J AU Makihira, S Nikawa, H Kajiya, M Kawai, T Mine, Y Kosaka, E Silva, MJB Tobiume, K Terada, Y AF Makihira, Seicho Nikawa, Hiroki Kajiya, Mikihito Kawai, Toshihisa Mine, Yuichi Kosaka, Eduardo Silva, Marcelo J. B. Tobiume, Kei Terada, Yoshihiro TI Blocking of sodium and potassium ion-dependent adenosine triphosphatase-alpha 1 with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article DE Osteoclast; RANKL; Na(+)/K(+)-ATPase; Ouabain; Vanadate; DC-STAMP ID LESS-THAN-OR-EQUAL-TO-5 NUCLEI OSTEOCLASTS; LARGE GREATER-THAN-OR-EQUAL-TO-10 NUCLEI; NA+/K+-ATPASE; GIANT-CELLS; DC-STAMP; ACTIVATION; APOPTOSIS; SUBUNIT; PROTEIN; PUMP AB To examine the possible enrolment of Na(+)/K(+)-ATPase during osteoclast differentiation. Na(+)/K(+)-ATPase inhibitors, including ouabain and vanadate, were used in this study. These inhibitors significantly inhibited cell-cell fusion of RAW264.7 cells and bone marrow cells induced by RANKL Interestingly, in response to RANKL-stimulation, ouabain and vanadate decreased the number of large TRAP+ osteoclasts in the culture of RAW264.7 cells, as well as bone marrow cells. In contrast, the number of small TRAP+ osteoclasts either increased in RAW264.7 cells or were otherwise less affected in bone marrow cells than large TRAP+ osteoclasts. Large TRAP+ osteoclasts are defined as having >= 10 nuclei/cell and having more potency in bone resorption than small multinuclear osteoclasts with <9 nuclei/cell. Na(+)/K(+)-ATPase alpha 1 and beta 2 mRNAs were detected in sRANKL-stimulated RAW264.7 cells. Moreover, real-time quantitative PCR showed that ouabain and vanadate suppressed the RANKL-dependent induction of the osteoclast fusion-promotion molecule DC-STAMP at the mRNA level. Finally, and importantly, RNAi-mediated suppression of Na(+)/K(+)-ATPase alpha 1 resulted in a diminished number of large TRAP+ osteoclasts in the sRANKL-stimulated RAW264.7 cells, along with the decreased level of DC-STAMP mRNA expression. These findings strongly suggest that blockage of the Na(+)/K(+)-ATPase alpha 1 subunit by ouabain or vanadate caused the inhibition of RANKL-induced cell-cell fusion, resulting in the generation of large osteoclasts through suppression of DC-STAMP expression. Thus, in addition to its known function of sodium and potassium ion exchange during bone resorption by mature osteoclasts, this study has revealed a novel molecular role of the Na(+)/K(+)-ATPase alpha 1 subunit in osteoclastogenesis. (C) 2011 Elsevier B.V. All rights reserved. C1 [Makihira, Seicho; Terada, Yoshihiro] Kyushu Univ, Fac Dent Sci, Dept Oral Rehabil, Sect Fixed Prosthodont, Fukuoka 8128582, Japan. [Nikawa, Hiroki; Mine, Yuichi; Kosaka, Eduardo] Hiroshima Univ, Grad Sch Biomed Sci, Div Oral Hlth Sci, Dept Oral Biol & Engn, Hiroshima 7348553, Japan. [Kajiya, Mikihito; Kawai, Toshihisa; Silva, Marcelo J. B.] Forsyth Inst, Dept Immunol, Cambridge, MA 02142 USA. [Kajiya, Mikihito; Kawai, Toshihisa] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA. [Tobiume, Kei] Hiroshima Univ, Grad Sch Biomed Sci, Div Med Intelligence & Informat, Hiroshima 7348553, Japan. RP Makihira, S (reprint author), Kyushu Univ, Fac Dent Sci, Dept Oral Rehabil, Sect Fixed Prosthodont, 3-1-1 Maidashi Higashi Ku, Fukuoka 8128582, Japan. EM makihira@dent.kyushu-u.ac.jp RI Silva, Marcelo/J-4298-2012; U-ID, Kyushu/C-5291-2016 OI Silva, Marcelo/0000-0002-5807-4286; FU Japan Society for the Promotion of Science [18689046, 21390516]; NIH [DE-018499, DE-019917]; JICA FX This study was supported, in part, by a grant-in-aid for scientific research from the Japan Society for the Promotion of Science (Grant Nos. 18689046 and 21390516) and by NIH RO1 grants DE-018499 and DE-019917. We acknowledge the constructive and intuitive suggestions by Professor Roland Baron at the Harvard School of Dental Medicine. Eduardo Kosaka was supported by the scholarship from the JICA program. This work was partly carried out with the kind cooperation of the Analysis Center of Life Science, Hiroshima University. NR 32 TC 4 Z9 4 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD NOV 30 PY 2011 VL 670 IS 2-3 BP 409 EP 418 DI 10.1016/j.ejphar.2011.08.044 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 853TQ UT WOS:000297449000010 PM 21945676 ER PT J AU Li, XB Large, CH Ricci, R Taylor, JJ Nahas, Z Bohning, DE Morgan, P George, MS AF Li, Xingbao Large, Charles H. Ricci, Raffaella Taylor, Joseph J. Nahas, Ziad Bohning, Daryl E. Morgan, Paul George, Mark S. TI Using interleaved transcranial magnetic stimulation/functional magnetic resonance imaging (fMRI) and dynamic causal modeling to understand the discrete circuit specific changes of medications: Lamotrigine and valproic acid changes in motor or prefrontal effective connectivity SO PSYCHIATRY RESEARCH-NEUROIMAGING LA English DT Article DE Transcranial magnetic stimulation; Neuroimaging; Dynamic causal modeling; Network; Lamotrigine; Valproic acid ID ANTIEPILEPTIC DRUGS; BIPOLAR DISORDER; CORTICAL EXCITABILITY; TMS; CORTEX; MECHANISMS; SYSTEM; MOOD; MRI; DEPRESSION AB The purpose of this study was to use interleaved transcranial magnetic stimulation/functional magnetic resonance imaging (TMS/fMRI) to investigate the effects of lamotrigine (LTG) and valproic acid (VPA) on effective connectivity within motor and corticolimbic circuits. In this randomized, double-blind, crossover trial, 30 healthy volunteers received either drug or placebo 3.5 h prior to interleaved TMS/fMRI. We utilized dynamic causal modeling (DCM) to assess changes in the endogenous effective connectivity of bidirectional networks in the motor-sensory system and corticolimbic circuit. Results indicate that both LTG and VPA have network-specific effects. When TMS was applied over the motor cortex, both LTG and VPA reduced TMS-specific effective connectivity between primary motor (M1) and pre-motor cortex (PMd), and between M1 and the supplementary area motor (SMA). When TMS was applied over prefrontal cortex, however, LTG alone increased TMS-specific effective connectivity between the left dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate cortex (ACC). In summary, LTG and VPA both inhibited effective connectivity in motor circuits, but LTG alone increased effective connectivity in prefrontal circuits. These results suggest that interleaved TMS/fMRI can assess region- and circuit-specific effects of medications or interventions. Published by Elsevier Ireland Ltd. C1 [Li, Xingbao] Med Univ S Carolina, Brain Stimulat Lab, MUSC IOP, Dept Psychiat, Charleston, SC 29425 USA. [Li, Xingbao; Taylor, Joseph J.; Bohning, Daryl E.; Morgan, Paul; George, Mark S.] Med Univ S Carolina, Ctr Adv Imaging Res, Charleston, SC 29425 USA. [Large, Charles H.] GlaxoSmithKline SpA, Med Res Ctr, Verona, Italy. [George, Mark S.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. RP Li, XB (reprint author), Med Univ S Carolina, Brain Stimulat Lab, MUSC IOP, Dept Psychiat, 502 N,67 President St, Charleston, SC 29425 USA. EM lixi@musc.edu FU GlaxoSmithKline; Center for Advanced Imaging Research; Brain Stimulation Laboratory FX This study was funded primarily by an unrestricted research grant from GlaxoSmithKline to Dr. George, as well as from Center for Advanced Imaging Research and Brain Stimulation Laboratory infrastructure and resources. CHL is a full-time employee of GlaxoSmithKline S.p.A. None of the other authors has equity or financial conflicts. Drs. Li and George had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Presented in abstract form at the annual meeting of American College of Neuropsychopharmacology, Hollywood, FL, Dec 14, 2006 and the annual meeting of the Society of Biological Psychiatry, San Diego, CA, May 21, 2007. NR 50 TC 15 Z9 15 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0925-4927 J9 PSYCHIAT RES-NEUROIM JI Psychiatry Res. Neuroimaging PD NOV 30 PY 2011 VL 194 IS 2 BP 141 EP 148 DI 10.1016/j.pscychresns.2011.04.012 PG 8 WC Clinical Neurology; Neuroimaging; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 843QD UT WOS:000296686200005 PM 21924874 ER PT J AU Traylor-Knowles, N Granger, BR Lubinski, TJ Parikh, JR Garamszegi, S Xia, Y Marto, JA Kaufman, L Finnerty, JR AF Traylor-Knowles, Nikki Granger, Brian R. Lubinski, Tristan J. Parikh, Jignesh R. Garamszegi, Sara Xia, Yu Marto, Jarrod A. Kaufman, Les Finnerty, John R. TI Production of a reference transcriptome and transcriptomic database (PocilloporaBase) for the cauliflower coral, Pocillopora damicornis SO BMC GENOMICS LA English DT Article ID REEF-BUILDING CORALS; NEMATOSTELLA-VECTENSIS; GENE-EXPRESSION; MONTASTRAEA-FAVEOLATA; GENOMICS DATABASE; ACROPORA-PALMATA; SEA-ANEMONE; STRESS; CONSERVATION; SYMBIOSIS AB Background: Motivated by the precarious state of the world's coral reefs, there is currently a keen interest in coral transcriptomics. By identifying changes in coral gene expression that are triggered by particular environmental stressors, we can begin to characterize coral stress responses at the molecular level, which should lead to the development of more powerful diagnostic tools for evaluating the health of corals in the field. Furthermore, the identification of genetic variants that are more or less resilient in the face of particular stressors will help us to develop more reliable prognoses for particular coral populations. Toward this end, we performed deep mRNA sequencing of the cauliflower coral, Pocillopora damicornis, a geographically widespread Indo-Pacific species that exhibits a great diversity of colony forms and is able to thrive in habitats subject to a wide range of human impacts. Importantly, P. damicornis is particularly amenable to laboratory culture. We collected specimens from three geographically isolated Hawaiian populations subjected to qualitatively different levels of human impact. We isolated RNA from colony fragments ("nubbins") exposed to four environmental stressors (heat, desiccation, peroxide, and hypo-saline conditions) or control conditions. The RNA was pooled and sequenced using the 454 platform. Description: Both the raw reads (n = 1, 116, 551) and the assembled contigs (n = 70, 786; mean length = 836 nucleotides) were deposited in a new publicly available relational database called PocilloporaBase http://www.PocilloporaBase.org. Using BLASTX, 47.2% of the contigs were found to match a sequence in the NCBI database at an E-value threshold of <=.001; 93.6% of those contigs with matches in the NCBI database appear to be of metazoan origin and 2.3% bacterial origin, while most of the remaining 4.1% match to other eukaryotes, including algae and amoebae. Conclusions: P. damicornis now joins the handful of coral species for which extensive transcriptomic data are publicly available. Through PocilloporaBase http://www.PocilloporaBase.org, one can obtain assembled contigs and raw reads and query the data according to a wide assortment of attributes including taxonomic origin, PFAM motif, KEGG pathway, and GO annotation. C1 [Granger, Brian R.; Lubinski, Tristan J.; Parikh, Jignesh R.; Kaufman, Les; Finnerty, John R.] Boston Univ, Dept Biol, Boston, MA 02215 USA. [Traylor-Knowles, Nikki] Stanford Univ, Hopkins Marine Stn, Dept Biol, Pacific Grove, CA 93950 USA. [Granger, Brian R.; Parikh, Jignesh R.; Garamszegi, Sara; Xia, Yu; Finnerty, John R.] Boston Univ, Bioinformat Program, Boston, MA 02215 USA. [Xia, Yu] Boston Univ, Dept Chem, Boston, MA 02215 USA. [Xia, Yu] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA. [Marto, Jarrod A.] Dana Farber Canc Inst, Dept Canc Biol & Blais Prote Ctr, Boston, MA 02115 USA. [Marto, Jarrod A.] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA. RP Finnerty, JR (reprint author), Boston Univ, Dept Biol, 5 Cummington St, Boston, MA 02215 USA. EM jrf3@bu.edu RI Finnerty, John/B-6564-2011; OI Xia, Yu/0000-0002-5596-5518 FU Conservation International Marine Management Area Science Program FX The authors would like to thank Jonathan Martinez, Luc Rougee, Bob Richmond and Laetitia Hedouin for assistance with permits and animal collections, Derek Stefanik for assistance with database conception, Mark Martindale and members of the Martindale Lab of Kewalo Marine Labs for logistical support and supplies. This research was supported by a grant from the Conservation International Marine Management Area Science Program to JRF. We are grateful to three anonymous reviewers for helping us to significantly improve the clarity of the manuscript and utility of the associated database. NR 38 TC 32 Z9 33 U1 0 U2 28 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD NOV 29 PY 2011 VL 12 AR 585 DI 10.1186/1471-2164-12-585 PG 11 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 907RV UT WOS:000301436200001 PM 22126435 ER PT J AU Shaw, SY Brettman, AD AF Shaw, Stanley Y. Brettman, Ari D. TI Phenotyping Patient-Derived Cells for Translational Studies in Cardiovascular Disease SO CIRCULATION LA English DT Article DE cells; genetics; genomic studies; pathway analysis; systems biology ID ENDOTHELIAL PROGENITOR CELLS; CORONARY-ARTERY-DISEASE; ACUTE MYOCARDIAL-INFARCTION; PLURIPOTENT STEM-CELLS; RESIDUAL PLATELET REACTIVITY; CIRCULATING TUMOR-CELLS; COLONY-FORMING-UNITS; GENE-EXPRESSION; MONOCYTE SUBSETS; RISK-FACTORS C1 [Shaw, Stanley Y.] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA. [Shaw, Stanley Y.] Broad Inst Harvard & MIT, Cambridge, MA USA. [Shaw, Stanley Y.; Brettman, Ari D.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Shaw, Stanley Y.; Brettman, Ari D.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. RP Shaw, SY (reprint author), Simches Res Ctr, CPZN 5226,185 Cambridge St, Boston, MA 02114 USA. EM shaw.stanley@mgh.harvard.edu FU NHLBI NIH HHS [K08 HL077186]; NLM NIH HHS [U54 LM008748, U54 LM008748-08] NR 123 TC 3 Z9 3 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 29 PY 2011 VL 124 IS 22 BP 2444 EP 2455 DI 10.1161/CIRCULATIONAHA.111.043943 PG 12 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 862YT UT WOS:000298130700016 PM 22125190 ER PT J AU McCann, CK Growdon, WB Kulkarni-Datar, K Curley, MD Friel, AM Proctor, JL Sheikh, H Deyneko, I Ferguson, JA Vathipadiekal, V Birrer, MJ Borger, DR Mohapatra, G Zukerberg, LR Foster, R MacDougall, JR Rueda, BR AF McCann, Christopher K. Growdon, Whitfield B. Kulkarni-Datar, Kashmira Curley, Michael D. Friel, Anne M. Proctor, Jennifer L. Sheikh, Hana Deyneko, Igor Ferguson, Jeanne A. Vathipadiekal, Vinod Birrer, Michael J. Borger, Darrell R. Mohapatra, Gayatry Zukerberg, Lawrence R. Foster, Rosemary MacDougall, John R. Rueda, Bo R. TI Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model SO PLOS ONE LA English DT Article ID PROSTATE-CANCER; STEM-CELL; PATHWAY; MEDULLOBLASTOMA; PROLIFERATION; ACTIVATION; PARADIGMS; THERAPY AB Background: Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to determine if inhibition of this pathway could inhibit serous ovarian cancer growth. Methodology: We utilized an in vivo pre-clinical model of serous ovarian cancer to characterize the anti-tumor activity of Hh pathway inhibitors cyclopamine and a clinically applicable derivative, IPI-926. Primary human serous ovarian tumor tissue was used to generate tumor xenografts in mice that were subsequently treated with cyclopamine or IPI-926. Principal Findings: Both compounds demonstrated significant anti-tumor activity as single agents. When IPI-926 was used in combination with paclitaxel and carboplatinum (T/C), no synergistic effect was observed, though sustained treatment with IPI-926 after cessation of T/C continued to suppress tumor growth. Hh pathway activity was analyzed by RT-PCR to assess changes in Gli1 transcript levels. A single dose of IPI-926 inhibited mouse stromal Gli1 transcript levels at 24 hours with unchanged human intra-tumor Gli1 levels. Chronic IPI-926 therapy for 21 days, however, inhibited Hh signaling in both mouse stromal and human tumor cells. Expression data from the micro-dissected stroma in human serous ovarian tumors confirmed the presence of Gli1 transcript and a significant association between elevated Gli1 transcript levels and worsened survival. Conclusions/Significance: IPI-926 treatment inhibits serous tumor growth suggesting the Hh signaling pathway contributes to the pathogenesis of ovarian cancer and may hold promise as a novel therapeutic target, especially in the maintenance setting. C1 [McCann, Christopher K.; Growdon, Whitfield B.; Kulkarni-Datar, Kashmira; Curley, Michael D.; Friel, Anne M.; Foster, Rosemary; Rueda, Bo R.] Massachusetts Gen Hosp, Dept Vincent Obstet & Gynecol, Vincent Ctr Reprod Biol, Boston, MA 02114 USA. [McCann, Christopher K.; Growdon, Whitfield B.; Rueda, Bo R.] Massachusetts Gen Hosp, Div Gynecol Oncol, Dept Vincent Obstet & Gynecol, Boston, MA 02114 USA. [McCann, Christopher K.; Growdon, Whitfield B.; Kulkarni-Datar, Kashmira; Curley, Michael D.; Friel, Anne M.; Vathipadiekal, Vinod; Birrer, Michael J.; Borger, Darrell R.; Mohapatra, Gayatry; Zukerberg, Lawrence R.; Foster, Rosemary; Rueda, Bo R.] Harvard Univ, Sch Med, Boston, MA USA. [Proctor, Jennifer L.; Sheikh, Hana; Deyneko, Igor; Ferguson, Jeanne A.; MacDougall, John R.] Infin Pharmaceut, Cambridge, MA USA. [Vathipadiekal, Vinod; Birrer, Michael J.; Borger, Darrell R.; Mohapatra, Gayatry] Massachusetts Gen Hosp, Div Hematol Oncol, Ctr Canc, Boston, MA 02114 USA. [Zukerberg, Lawrence R.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. RP McCann, CK (reprint author), Massachusetts Gen Hosp, Dept Vincent Obstet & Gynecol, Vincent Ctr Reprod Biol, Boston, MA 02114 USA. EM brueda@partners.org OI Vathipadiekal, Vinod/0000-0002-8181-6890 FU Ovarian Cancer Research Fund; Advanced Medical Research Foundation; Vincent Memorial Research Funds FX This research was funded by grants from the Ovarian Cancer Research Fund (BRR), Advanced Medical Research Foundation (BRR), and the Vincent Memorial Research Funds (BRR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 27 TC 27 Z9 28 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 29 PY 2011 VL 6 IS 11 AR e28077 DI 10.1371/journal.pone.0028077 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863LT UT WOS:000298166300025 PM 22140510 ER PT J AU Nair, P Spiegelman, BM AF Nair, Prashant Spiegelman, Bruce M. TI QnAs with Bruce M. Spiegelman SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Editorial Material C1 [Spiegelman, Bruce M.] Dana Farber Canc Inst, Boston, MA USA. [Spiegelman, Bruce M.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 29 PY 2011 VL 108 IS 48 BP 19121 EP 19121 DI 10.1073/pnas.1117668108 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 853ZB UT WOS:000297463100011 ER PT J AU Ballabeni, A Park, IH Zhao, R Wang, WP Lerou, PH Daley, GQ Kirschner, MW AF Ballabeni, Andrea Park, In-Hyun Zhao, Rui Wang, Weiping Lerou, Paul H. Daley, George Q. Kirschner, Marc W. TI Cell cycle adaptations of embryonic stem cells SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE pluripotency; differentiation; protein degradation ID ANAPHASE-PROMOTING COMPLEX; S-PHASE ENTRY; DNA-REPLICATION; MITOTIC REGULATOR; DEPENDENT KINASES; UBIQUITIN CHAINS; GEMININ; MITOSIS; DIFFERENTIATION; REREPLICATION AB ES cells proliferate with very short gap phases yet maintain their capacity to differentiate. It had been thought that the levels of cyclins and other substrates of ubiquitin ligase APC/C remain nearly constant and Cdk activity remains constitutively high in mouse ES cells. Here we demonstrate that APC/C (anaphase-promoting complex/cyclosome) enzyme is active in ES cells but attenuated by high levels of the Emi1 (early mitotic inhibitor-1) protein. Despite the presence of high Cdk activity during the G1 phase, chromatin can be effectively licensed for DNA replication and fast entry into the S phase can still occur. High Cdk activity during S-G2-M phases produces high levels of the DNA replication factor Cdt1, and this leads to efficient Mcm proteins loading on chromatin after mitotic exit. Although disturbing the usual balance between Cdk activity and APC/C activity found in somatic cells, a few key adaptations allow normal progression of a very rapid cell cycle. C1 [Ballabeni, Andrea; Wang, Weiping; Kirschner, Marc W.] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA. [Zhao, Rui; Daley, George Q.] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA. [Park, In-Hyun] Yale Univ, Sch Med, Yale Stem Cell Ctr, Dept Genet, New Haven, CT 06520 USA. [Zhao, Rui; Daley, George Q.] Childrens Hosp Boston, Stem Cell Transplantat Program, Div Pediat Hematol Oncol, Manton Ctr Orphan Dis Res,Howard Hughes Med Inst, Boston, MA 02115 USA. [Zhao, Rui; Daley, George Q.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lerou, Paul H.] Harvard Univ, Sch Med, Dept Newborn Med,Childrens Hosp, Brigham & Womens Hosp,Harvard Stem Cell Inst, Boston, MA 02115 USA. [Daley, George Q.] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA. [Zhao, Rui; Daley, George Q.] Harvard Stem Cell Inst, Cambridge, MA 02138 USA. RP Kirschner, MW (reprint author), Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA. EM marc@hms.harvard.edu FU National Institutes of Health (NIH) [R01GM026875, K99HD061981]; Charles H. Hood Foundation; Children's Hospital Trust; Harvard Stem Cell Institute FX We thank Sean Irwin, Hongguang Huo, and Raffaella Zamponi for technical support, and Tao Wu for providing reagents for degradation assays. This work was supported in part by National Institutes of Health (NIH) Grant R01GM026875 (to M. W. K.; also supported A.B. and W.W.); the Charles H. Hood Foundation (I.-H.P.); NIH Grant K99HD061981 (to G.Q.D.; also supported R.Z.); an Instructor Development Award from the Harvard Stem Cell Institute (to P.H.L.); a grant from the Harvard Stem Cell Institute (to G.Q.D.); and private funds from the Children's Hospital Trust (to G.Q.D.). NR 33 TC 36 Z9 37 U1 1 U2 7 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 29 PY 2011 VL 108 IS 48 BP 19252 EP 19257 DI 10.1073/pnas.1116794108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 853ZB UT WOS:000297463100036 PM 22084091 ER PT J AU Miletich, I Yu, WY Zhang, RF Yang, K de Andrade, SC Pereira, SFD Ohazama, A Mock, OB Buchner, G Sealby, J Webster, Z Zhao, ML Bei, M Sharpe, PT AF Miletich, Isabelle Yu, Wei-Yuan Zhang, Ruofang Yang, Kai de Andrade, Simone Caixeta Pereira, Silvia Fontes do A. Ohazama, Atsushi Mock, Orin B. Buchner, Georg Sealby, Jane Webster, Zoe Zhao, Minglian Bei, Marianna Sharpe, Paul T. TI Developmental stalling and organ-autonomous regulation of morphogenesis SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE heterochrony; odontogenesis; molar; shrew ID TOOTH DEVELOPMENT; MOUSE TOOTH; ENAMEL KNOT; MSX1; GENE; BARX1; MICE; ABNORMALITIES; INHIBITION; EXPRESSION AB Timing of organ development during embryogenesis is coordinated such that at birth, organ and fetal size and maturity are appropriately proportioned. The extent to which local developmental timers are integrated with each other and with the signaling interactions that regulate morphogenesis to achieve this end is not understood. Using the absolute requirement for a signaling pathway activity (bone morphogenetic protein, BMP) during a critical stage of tooth development, we show that suboptimal levels of BMP signaling do not lead to abnormal morphogenesis, as suggested by mutants affecting BMP signaling, but to a 24-h stalling of the intrinsic developmental clock of the tooth. During this time, BMP levels accumulate to reach critical levels whereupon tooth development restarts, accelerates to catch up with development of the rest of the embryo and completes normal morphogenesis. This suggests that individual organs can autonomously control their developmental timing to adjust their stage of development to that of other organs. We also find that although BMP signaling is critical for the bud-tocap transition in all teeth, levels of BMP signaling are regulated differently in multicusped teeth. We identify an interaction between two homeodomain transcription factors, Barx1 and Msx1, which is responsible for setting critical levels of BMP activity in multicusped teeth and provides evidence that correlates the levels of Barx1 transcriptional activity with cuspal complexity. This study highlights the importance of absolute levels of signaling activity for development and illustrates remarkable self-regulation in organogenesis that ensures coordination of developmental processes such that timing is subordinate to developmental structure. C1 [Miletich, Isabelle; Yu, Wei-Yuan; Zhang, Ruofang; Yang, Kai; de Andrade, Simone Caixeta; Pereira, Silvia Fontes do A.; Ohazama, Atsushi; Buchner, Georg; Sharpe, Paul T.] Kings Coll London, Guys Hosp, Inst Dent, Dept Craniofacial Dev, London SE1 6RT, England. [de Andrade, Simone Caixeta] Univ Estadual Campinas, Dept Morphol, Piracicaba Dent Sch, Sp Campinas, Brazil. [Mock, Orin B.] AT Still Univ, Coll Osteopath Med, Kirksville, MO 63501 USA. [Sealby, Jane; Webster, Zoe] Univ London Imperial Coll Sci Technol & Med, Med Res Council Clin Sci Ctr, Embryon Stem Cell Facil, London W12 0NN, England. [Zhao, Minglian; Bei, Marianna] Forsyth Inst, Ctr Regenerat Dev Biol, Boston, MA 02115 USA. [Bei, Marianna] Massachusetts Gen Hosp, Ctr Engn Med, Dept Surg, Boston, MA 02129 USA. [Bei, Marianna] Harvard Univ, Sch Med, Boston, MA 02129 USA. RP Sharpe, PT (reprint author), Kings Coll London, Guys Hosp, Inst Dent, Dept Craniofacial Dev, London SE1 6RT, England. EM paul.sharpe@kcl.ac.uk RI andrade, simone/E-8511-2012 OI andrade, simone/0000-0002-9988-7881 FU Wellcome Trust; Research Councils UK; Coordination for the Improvement of Higher Education Personnel (CAPES) Foundation [BEX 5408/10-5] FX We thank Benoit Robert for generously providing the Msx1 mutant mice and Jeremy Green for helpful discussion and comments. Work in the United Kingdom was supported by the Wellcome Trust (P.T.S.) and Research Councils UK (I.M.). S.C.A. had a scholarship from the Coordination for the Improvement of Higher Education Personnel (CAPES) Foundation BEX 5408/10-5. NR 24 TC 15 Z9 16 U1 0 U2 8 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 29 PY 2011 VL 108 IS 48 BP 19270 EP 19275 DI 10.1073/pnas.1112801108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 853ZB UT WOS:000297463100039 PM 22084104 ER PT J AU Kosugi, M Ahmad, R Alam, M Uchida, Y Kufe, D AF Kosugi, Michio Ahmad, Rehan Alam, Maroof Uchida, Yasumitsu Kufe, Donald TI MUC1-C Oncoprotein Regulates Glycolysis and Pyruvate Kinase m2 Activity in Cancer Cells SO PLOS ONE LA English DT Article ID BETA-CATENIN; TUMOR-GROWTH; CARCINOMA ANTIGEN; SURVIVAL RESPONSE; LUNG-CANCER; C-SRC; METABOLISM; PROTEIN; PHOSPHORYLATION; PROLIFERATION AB Aerobic glycolysis in cancer cells is regulated by multiple effectors that include Akt and pyruvate kinase M2 (PKM2). Mucin 1 (MUC1) is a heterodimeric glycoprotein that is aberrantly overexpressed by human breast and other carcinomas. Here we show that transformation of rat fibroblasts by the oncogenic MUC1-C subunit is associated with Akt-mediated increases in glucose uptake and lactate production, consistent with the stimulation of glycolysis. The results also demonstrate that the MUC1-C cytoplasmic domain binds directly to PKM2 at the B-and C-domains. Interaction between the MUC1-C cytoplasmic domain Cys-3 and the PKM2 C-domain Cys-474 was found to stimulate PKM2 activity. Conversely, epidermal growth factor receptor (EGFR)-mediated phosphorylation of the MUC1-C cytoplasmic domain on Tyr-46 conferred binding to PKM2 Lys-433 and inhibited PKM2 activity. In human breast cancer cells, silencing MUC1-C was associated with decreases in glucose uptake and lactate production, confirming involvement of MUC1-C in the regulation of glycolysis. In addition, EGFR-mediated phosphorylation of MUC1-C in breast cancer cells was associated with decreases in PKM2 activity. These findings indicate that the MUC1-C subunit regulates glycolysis and that this response is conferred in part by PKM2. Thus, the overexpression of MUC1-C oncoprotein in diverse human carcinomas could be of importance to the Warburg effect of aerobic glycolysis. C1 [Kosugi, Michio; Ahmad, Rehan; Alam, Maroof; Uchida, Yasumitsu; Kufe, Donald] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RP Kosugi, M (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, 44 Binney St, Boston, MA 02115 USA. EM donald_kufe@dfci.harvard.edu FU National Cancer Institute [CA97098, CA42802, CA100707] FX This work was supported by Grants CA97098, CA42802 and CA100707 awarded by the National Cancer Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 19 Z9 19 U1 0 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 28 PY 2011 VL 6 IS 11 AR e28234 DI 10.1371/journal.pone.0028234 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KW UT WOS:000298163400040 PM 22140559 ER PT J AU Leder, K Foo, J Skaggs, B Gorre, M Sawyers, CL Michor, F AF Leder, Kevin Foo, Jasmine Skaggs, Brian Gorre, Mercedes Sawyers, Charles L. Michor, Franziska TI Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-Existing Resistance in Chronic Myeloid Leukemia SO PLOS ONE LA English DT Article ID CHRONIC MYELOGENOUS LEUKEMIA; LURIA-DELBRUCK DISTRIBUTION; DRUG-RESISTANCE; CLONAL EXPANSION; IMATINIB RESISTANCE; TYROSINE KINASE; CHRONIC-PHASE; CANCER; MODEL; EVOLUTION AB Chronic myeloid leukemia (CML) is the first human malignancy to be successfully treated with a small molecule inhibitor, imatinib, targeting a mutant oncoprotein (BCR-ABL). Despite its successes, acquired resistance to imatinib leads to reduced drug efficacy and frequent progression of disease. Understanding the characteristics of pre-existing resistant cells is important for evaluating the benefits of first-line combination therapy with second generation inhibitors. However, due to limitations of assay sensitivity, determining the existence and characteristics of resistant cell clones at the start of therapy is difficult. Here we combined a mathematical modeling approach using branching processes with experimental data on the fitness changes (i.e., changes in net reproductive rate) conferred by BCR-ABL kinase domain mutations to investigate the likelihood, composition, and diversity of pre-existing resistance. Furthermore, we studied the impact of these factors on the response to tyrosine kinase inhibitors. Our approach predicts that in most patients, there is at most one resistant clone present at the time of diagnosis of their disease. Interestingly, patients are no more likely to harbor the most aggressive, pan-resistant T315I mutation than any other resistance mutation; however, T315I cells on average establish larger-sized clones at the time of diagnosis. We established that for patients diagnosed late, the relative benefit of combination therapy over monotherapy with imatinib is significant, while this benefit is modest for patients with a typically early diagnosis time. These findings, after pre-clinical validation, will have implications for the clinical management of CML: we recommend that patients with advanced-phase disease be treated with combination therapy with at least two tyrosine kinase inhibitors. C1 [Leder, Kevin] Univ Minnesota, Program Ind & Syst Engn, Minneapolis, MN 55455 USA. [Foo, Jasmine] Univ Minnesota, Sch Math, Minneapolis, MN 55455 USA. [Skaggs, Brian] David Geffen Univ Calif Los Angeles, Sch Med, Div Rheumatol, Los Angeles, CA USA. [Gorre, Mercedes] Combimatrix, Irvine, CA USA. [Sawyers, Charles L.] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA. [Michor, Franziska] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Michor, Franziska] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. RP Leder, K (reprint author), Univ Minnesota, Program Ind & Syst Engn, Minneapolis, MN 55455 USA. EM michor@jimmy.harvard.edu RI Sawyers, Charles/G-5327-2016 FU NCI (National Cancer Institute) [U54CA143798] FX This work was supported through NCI (National Cancer Institute) grant U54CA143798. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 21 Z9 22 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 28 PY 2011 VL 6 IS 11 AR e27682 DI 10.1371/journal.pone.0027682 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KW UT WOS:000298163400012 PM 22140458 ER PT J AU Levine, DA Funkhouser, EM Houston, TK Gerald, JK Johnson-Roe, N Allison, JJ Richman, J Kiefe, CI AF Levine, Deborah A. Funkhouser, Ellen M. Houston, Thomas K. Gerald, Joe K. Johnson-Roe, Nancy Allison, Jeroan J. Richman, Joshua Kiefe, Catarina I. TI Improving Care After Myocardial Infarction Using a 2-Year Internet-Delivered Intervention The Department of Veterans Affairs Myocardial Infarction-Plus Cluster-Randomized Trial SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID CORONARY-HEART-DISEASE; CONTINUOUS-QUALITY-IMPROVEMENT; RE-AIM FRAMEWORK; MEDICARE BENEFICIARIES; SECONDARY PREVENTION; MANAGEMENT PROGRAMS; CARDIAC-DISEASE; AMBULATORY-CARE; RISK-FACTORS; MI-PLUS AB Background: Cardiovascular risk reduction in ambulatory patients who survive myocardial infarction (MI) is effective but underused. We sought to evaluate a provider-directed, Internet-delivered intervention to improve cardiovascular management for post-MI outpatients. Methods: The Department of Veterans Affairs (VA) MI-Plus study was a cluster-randomized trial involving 168 community-based primary care clinics and 847 providers in 26 states, the Virgin Islands, and Puerto Rico, from January 1, 2002, through December 31, 2008, with the clinic as the randomization unit. We collected administrative data for 15 847 post-MI patients and medical record data for 10 452 of these. A multicomponent, Internet-delivered intervention included quarterly educational modules, practice guidelines, monthly literature summaries, and automated e-mail reminders delivered to providers for 27 months. Main outcome measures included percentage of patients who achieved each of 7 clinical indicators, a composite score of the 7 clinical indicators, and mean low-density lipoprotein cholesterol and hemoglobin A(1c) levels. Results: Clinics had a median of 3 providers (interquartile range, 2-6), with a median of 50.0% of providers (33.3%-66.7%) participating in the study. Patients in intervention clinics had greater improvements (from 70.0% to 85.5%) in the percentages prescribed beta-blockers than patients in control clinics (71.9% to 84.0%; adjusted improvement gain for intervention vs control, 2.6%; 95% CI, 0.1%-4.1%). We found nonsignificant differences in improvements favoring patients in intervention clinics for 5 of 6 remaining clinical indicators and levels of low-density lipoprotein cholesterol and hemoglobin A(1c). Conclusion: A longitudinal, Internet-delivered intervention improved only 1 of 7 clinical indicators of cardiovascular management in ambulatory post-MI patients. C1 [Levine, Deborah A.] Univ Michigan, Div Gen Med, Dept Med, Ann Arbor, MI 48109 USA. [Levine, Deborah A.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA. [Levine, Deborah A.] Ann Arbor Vet Affairs VA Healthcare Syst, Ann Arbor, MI USA. [Levine, Deborah A.; Funkhouser, Ellen M.] Univ Alabama Birmingham Sch Med, Dept Med, Birmingham, AL USA. [Richman, Joshua] Univ Alabama Birmingham Sch Med, Dept Surg, Birmingham, AL USA. [Johnson-Roe, Nancy; Richman, Joshua] Birmingham VA Med Ctr, VA Res Enhancement Award Program, Birmingham, AL USA. [Houston, Thomas K.; Allison, Jeroan J.; Kiefe, Catarina I.] Univ Massachusetts, Sch Med, Dept Quantitat Hlth Sci, Worcester, MA USA. [Allison, Jeroan J.; Kiefe, Catarina I.] Univ Massachusetts, Sch Med, Transit Risks & Act Coronary Events Ctr Outcomes, Worcester, MA USA. [Houston, Thomas K.] Bedford VA Med Ctr, Ctr Hlth Qual Outcomes & Econ Res, Bedford, MA USA. [Gerald, Joe K.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Publ Hlth Policy & Management, Tucson, AZ USA. RP Levine, DA (reprint author), Univ Michigan, Div Gen Med, Dept Med, 300 N Ingalls St,Room 7C27, Ann Arbor, MI 48109 USA. EM deblevin@umich.edu RI Houston, Thomas/F-2469-2013; OI Allison, Jeroan/0000-0003-4472-2112 FU VA Health Services Research and Development office [IHD-04-387]; National Institutes of Health [R01 HL70786-02] FX This study was supported by grant IHD-04-387 from the VA Health Services Research and Development office and grant R01 HL70786-02 from the National Institutes of Health for a parallel study. NR 51 TC 8 Z9 8 U1 0 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV 28 PY 2011 VL 171 IS 21 BP 1910 EP 1917 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 853JV UT WOS:000297423000006 PM 22123798 ER PT J AU Alia, I de la Cal, MA Esteban, A Abella, A Ferrer, R Molina, FJ Torres, A Gordo, F Elizalde, JJ de Pablo, R Huete, A Anzueto, A AF Alia, Inmaculada de la Cal, Miguel A. Esteban, Andres Abella, Ana Ferrer, Ricard Molina, Francisco J. Torres, Antoni Gordo, Federico Elizalde, Jose J. de Pablo, Raul Huete, Alejandro Anzueto, Antonio TI Efficacy of Corticosteroid Therapy in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease Receiving Ventilatory Support SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID ACUTE RESPIRATORY-FAILURE; INTENSIVE-CARE-UNIT; COMMUNITY-ACQUIRED PNEUMONIA; RANDOMIZED CONTROLLED-TRIAL; INVASIVE MECHANICAL VENTILATION; PLACEBO-CONTROLLED TRIAL; NONINVASIVE VENTILATION; SYSTEMIC GLUCOCORTICOIDS; DISTRESS-SYNDROME; CLINICAL-COURSE AB Background: Randomized trials assessing the effect of systemic corticosteroids on chronic obstructive pulmonary disease (COPD) exacerbations excluded patients who were mechanically ventilated or admitted to the intensive care unit (ICU). Critically ill patients constitute a population of persons who are prone to develop complications that are potentially associated with the use of corticosteroids (eg, infections, hyperglycemia, ICU-acquired paresis) that could prolong the duration of mechanical ventilation and even increase mortality. Methods: A double-blind placebo-controlled trial was conducted to evaluate the efficacy and safety of systemic corticosteroid treatment in patients with an exacerbation of COPD who were receiving ventilatory support (invasive or noninvasive mechanical ventilation). A total of 354 adult patients who were admitted to the ICUs of 8 hospitals in 4 countries from July 2005 through July 2009 were screened, and 83 were randomized to receive intravenous methylprednisolone (0.5 mg/kg every 6 hours for 72 hours, 0.5 mg/kg every 12 hours on days 4 through 6, and 0.5 mg/kg/d on days 7 through 10) or placebo. The main outcome measures were duration of mechanical ventilation, length of ICU stay, and need for intubation in patients treated with noninvasive mechanical ventilation. Results: There were no significant differences between the groups in demographics, severity of illness, reasons for COPD exacerbation, gas exchange variables, and corticosteroid rescue treatment. Corticosteroid treatment was associated with a significant reduction in the median duration of mechanical ventilation (3 days vs 4 days; P=.04), a trend toward a shorter median length of ICU stay (6 days vs 7 days; P=.09), and significant reduction in the rate of NIV failure (0% vs 37%; P=.04). Conclusion: Systemic corticosteroid therapy in patients with COPD exacerbations requiring mechanical ventilation is associated with a significant increase in the success of noninvasive mechanical ventilation and a reduction in the duration of mechanical ventilation C1 [Alia, Inmaculada; de la Cal, Miguel A.; Esteban, Andres; Abella, Ana; Huete, Alejandro] Hosp Univ Getafe, Intens Care Units ICUs, Ctr Invest Biomed Red Enfermedades Resp CIBERes, Getafe, Spain. [Ferrer, Ricard] Consorci Hosp Parc Tauli, CIBERes, Sabadell, Spain. [Torres, Antoni] Hosp Clin Barcelona, CIBERes, Barcelona, Spain. [Molina, Francisco J.] Clin Univ Bolivariana, ICU, Medellin, Colombia. [Gordo, Federico] Hosp Univ Fdn Alcorcon, ICU, Madrid, Spain. [Elizalde, Jose J.] Hosp ABC, ICU, Mexico City, DF, Mexico. [de Pablo, Raul] Hosp Univ Principe Asturias, ICU, Alcala De Henares, Spain. [Anzueto, Antonio] Univ Texas Hlth Sci Ctr, ICU, San Antonio, TX USA. [Anzueto, Antonio] S Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Esteban, A (reprint author), Hosp Getafe, Unidad Cuidados Intens, Carretera Toledo Km 12-5, Getafe 28905, Spain. EM aesteban@ucigetafe.com FU Fondo de Investigacion Sanitaria [PI041233] FX This study was funded in part by grant PI041233 from Fondo de Investigacion Sanitaria. NR 44 TC 29 Z9 29 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV 28 PY 2011 VL 171 IS 21 BP 1939 EP 1946 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 853JV UT WOS:000297423000013 PM 22123804 ER PT J AU Cao, Y Kenfield, S Song, Y Rosner, B Qiu, WL Sesso, HD Gaziano, JM Ma, J AF Cao, Yin Kenfield, Stacey Song, Yan Rosner, Bernard Qiu, Weiliang Sesso, Howard D. Gaziano, J. Michael Ma, Jing TI Cigarette Smoking Cessation and Total and Cause-Specific Mortality: A 22-Year Follow-up Study Among US Male Physicians SO ARCHIVES OF INTERNAL MEDICINE LA English DT Letter ID WOMEN C1 [Cao, Yin; Kenfield, Stacey; Rosner, Bernard; Qiu, Weiliang; Ma, Jing] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. [Sesso, Howard D.; Gaziano, J. Michael] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. [Sesso, Howard D.; Gaziano, J. Michael] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA. [Cao, Yin; Kenfield, Stacey] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Song, Yan] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Song, Yan] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA. [Song, Yan] Univ Calif Los Angeles, Program Genom & Nutr, Los Angeles, CA USA. [Gaziano, J. Michael] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol & Res Informat Ctr MA, Boston, MA USA. RP Ma, J (reprint author), Brigham & Womens Hosp, Dept Med, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA. EM jing.ma@channing.harvard.edu FU NCI NIH HHS [CA-097193, CA-34944, CA-40360, CA42182, R01 CA034944, R01 CA040360, R01 CA042182, R01 CA097193, R01 CA097193-10]; NHLBI NIH HHS [R01 HL026490, HL-26490, HL-34595, R01 HL034595] NR 7 TC 12 Z9 12 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV 28 PY 2011 VL 171 IS 21 BP 1956 EP 1959 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 853JV UT WOS:000297423000020 PM 22123811 ER PT J AU Boas, DA Franceschini, MA AF Boas, David A. Franceschini, Maria Angela TI Haemoglobin oxygen saturation as a biomarker: the problem and a solution SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Review DE near-infrared spectroscopy; haemoglobin oxygen saturation; oxygen metabolism; muscle; breast; brain ID NEAR-INFRARED SPECTROSCOPY; DIFFUSE OPTICAL SPECTROSCOPY; PERIPHERAL VASCULAR-DISEASE; MODIFIED GRUBBS EXPONENT; CEREBRAL BLOOD-VOLUME; HEALTHY-HUMAN BRAINS; BREAST-CANCER; CAROTID-ENDARTERECTOMY; NONINVASIVE MEASUREMENT; TRANSCRANIAL DOPPLER AB Near-infrared spectroscopy measures of haemoglobin oxygen saturation are often used as an indicator of sufficient oxygen delivery to assess injury susceptibility and tissue damage. They have also often been used as a surrogate measure of oxygen metabolism. Unfortunately, these measures have generally failed to provide robust indicators of injury and metabolism. In this paper, we first review when haemoglobin oxygen saturation does work as a robust indicator, and then detail when and why it fails for assessing brain injury and breast cancer. Finally, we discuss the solution to obtain more robust measures of tissue injury and cancer by combining oxygen saturation measurements with measures of blood flow and volume to more accurately estimate oxygen metabolism. C1 [Boas, David A.; Franceschini, Maria Angela] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Opt Div,Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA. RP Boas, DA (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Opt Div,Martinos Ctr Biomed Imaging, 149 13th St,Rm 2301, Charlestown, MA 02129 USA. EM dboas@nmr.mgh.harvard.edu FU National Institute of Health [R01-EB06385, P41-14075, R01-HD042908, R01-NS057476, P01-NS055104] FX Britton Chance's leadership in biomedical optics and mitochondrial respiration has inspired us in our endeavour to translate optical methods to the clinic and to unravel the dynamic energetic processes in health and disease. We will miss him but are comforted by the opportunity to follow in his giant footsteps. In preparing this presentation and manuscript, we are grateful for the assistance of and discussions from Juliette Selb, Nadege Roche-Labarbe, Ellen Grant, Abbas Yaseen, Bruce Tromberg, Arjun Yodh and Marco Ferrari. We acknowledge support from the National Institute of Health under R01-EB06385, P41-14075, R01-HD042908, R01-NS057476 and P01-NS055104. NR 72 TC 33 Z9 33 U1 1 U2 5 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1364-503X J9 PHILOS T R SOC A JI Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci. PD NOV 28 PY 2011 VL 369 IS 1955 BP 4407 EP 4424 DI 10.1098/rsta.2011.0250 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 842AV UT WOS:000296558900005 PM 22006898 ER PT J AU del Rio, ML Kurtz, J Perez-Martinez, C Ghosh, A Perez-Simon, JA Rodriguez-Barbosa, JI AF del Rio, Maria-Luisa Kurtz, Josef Perez-Martinez, Claudia Ghosh, Arnab Antonio Perez-Simon, Jose Rodriguez-Barbosa, Jose-Ignacio TI B- and T-Lymphocyte Attenuator Targeting Protects Against the Acute Phase of Graft Versus Host Reaction by Inhibiting Donor Anti-Host Cytotoxicity SO TRANSPLANTATION LA English DT Article DE BTLA; HVEM; Alloreactivity; GvHR; Cosignaling ID HERPESVIRUS ENTRY MEDIATOR; DENDRITIC CELLS; CD8+T CELLS; IN-VIVO; BTLA; ACTIVATION; DISEASE; TOLERANCE; RECEPTOR; SURVIVAL AB Background. B- and T-lymphocyte attenuator (BTLA) functions as a coinhibitory/ costimulatory molecule that belongs to the immunoglobulin superfamily and exhibits a pattern of expression restricted to the hematopoietic compartment. Engagement of BTLA by its ligand, herpes virus entry mediator (HVEM), delivers negative signals to T cells, whereas engagement of HVEM receptor on T cells by surface BTLA expressed on other immune cells costimulates T activation. Previous work has reported that parental donor BTLA knock-out or HVEM knock-out T cells adoptively transferred into nonirradiated F1 recipient mice survived poorly, and the rejection of host hematopoietic cells was attenuated compared with F1 recipients receiving wild-type T cells. Methods. Parent into nonirradiated immunocompetent F1 murine model of acute graft versus host reaction, which is induced with the adoptive transfer of splenocytes from donor B6 mice (H-2())(b) into F1 recipients (BALB/cxB6, H-2(d/b)), was used as an experimental approach to test the therapeutic effect of targeting BTLA during the course of an allogeneic immune response. Results. We herein provide evidence that administration of an anti-BTLA monoclonal antibody leads to significant reduction of donor anti-host allogeneic immune response against bone marrow and thymus during the acute phase of graft versus host reaction in a parent into nonirradiated F1 murine model of alloreactivity. Anti-BTLA protection against donor anti-host hematopoietic cell rejection correlated with impaired anti-host cytotoxic T-lymphocyte activity than reduction in T-cell number infiltrating host tissues. Conclusions. These findings place BTLA receptor as a potential immunoregulatory target for the modulation of cytotoxic T-lymphocyte-mediated alloresponses. C1 [del Rio, Maria-Luisa; Rodriguez-Barbosa, Jose-Ignacio] Univ Leon, Inst Biomed, Immunobiol Sect, Leon 24007, Spain. [Kurtz, Josef] Univ Cambridge Emmanuel Coll, Dept Biol, Boston, MA USA. [Kurtz, Josef] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Transplantat Biol Res Ctr, Boston, MA USA. [Perez-Martinez, Claudia] Univ Leon, Sch Vet Sci, Dept Anim Hlth, Sect Anat Pathol, Leon 24007, Spain. [Ghosh, Arnab] Mem Sloan Kettering Canc Ctr, Dept Immunol, New York, NY 10021 USA. [Ghosh, Arnab] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA. [Antonio Perez-Simon, Jose] Virgen del Rocio Univ Hosp, Dept Hematol, Seville, Spain. RP Rodriguez-Barbosa, JI (reprint author), Univ Leon, Inst Biomed, Immunobiol Sect, Leon 24007, Spain. EM ignacio.barbosa@unileon.es RI Perez-Martinez, Claudia/M-4759-2013; IBIS, ONCOHEMATOLOGI/P-3457-2015; OI Perez-Martinez, Claudia/0000-0001-8060-6368; Ghosh, Arnab/0000-0003-3355-5427; Rodriguez-Barbosa, Jose-Ignacio/0000-0001-7427-5654 FU Fondo de Investigaciones Sanitarias, Ministry of Health, Spanish Government [050021]; Department of Education of the Regional Government, Junta de Castilla y Leon [LE007A10-2] FX This work was supported by grants FIS PI#050021 (Fondo de Investigaciones Sanitarias, Ministry of Health, Spanish Government) and LE007A10-2 (Department of Education of the Regional Government, Junta de Castilla y Leon) (J.-I.R.-B.). NR 37 TC 7 Z9 7 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD NOV 27 PY 2011 VL 92 IS 10 BP 1085 EP 1093 DI 10.1097/TP.0b013e3182339d4a PG 9 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 845BP UT WOS:000296798100010 PM 21978997 ER PT J AU Tallaj, JA Pamboukian, SV George, JF Brown, RN Pajaro, OE Bourge, RC Cadeiras, M Smallfield, M Kirklin, JK McGiffin, DC AF Tallaj, Jose A. Pamboukian, Salpy V. George, James F. Brown, Robert N. Pajaro, Octavio E. Bourge, Robert C. Cadeiras, Martin Smallfield, Melissa Kirklin, James K. McGiffin, David C. TI Total Lymphoid Irradiation in Heart Transplantation: Long-Term Efficacy and Survival-An 18-Year Experience SO TRANSPLANTATION LA English DT Article DE Total lymphoid irradiation; Outcomes; Heart transplantation ID RISK-FACTORS; LUNG TRANSPLANTATION; CARDIAC TRANSPLANTATION; RECURRENT REJECTION; ALLOGRAFT-REJECTION; HODGKINS-DISEASE; IMMUNOSUPPRESSION; DEATH AB Background. Total lymphoid irradiation (TLI) has been used in transplantation for over 20 years and is currently used in a number of major heart transplant centers as a secondary therapy for recalcitrant recurrent rejection or rejection with hemodynamic compromise. The purpose of this study is to evaluate the long-term risks and efficacy of TLI in the treatment of rejection. Methods. Between 1990 and 1996, 73 adult patients (from 211 adult transplant recipients) received TLI for recurrent rejection (71%), rejection with hemodynamic compromise (25%), and rejection with vasculitis (4%). The treatment consisted of 80 cGy twice per week for 5 weeks. Fifty-five patients received at least 80% of the full dose (>640 cGy). Follow-up ended December 31, 2007, comprising a total 18 year experience. Results. Patients treated with TLI exhibited a short-term decrease in hazard for rejection in the first 12 months posttransplantation (relative risk, 0.36) but exhibited increased cumulative rejection over the long term. There were no differences in the rates of infection, allograft coronary disease, or malignancy, but seven patients developed myelodysplasia or acute myelogenous leukemia, four of those being the rare but uniformly fatal acute megakaryocytic leukemia type 7. Conclusions. Patients treated with TLI seemed to experience a reduction in the early hazard for rejection, but long-term outcomes indicate that such patients continued to accumulate more rejection and rejection-death events, likely because these patients were overall at much higher risk for rejection than the other patient groups. We observed minimal long-term complications, except for the unique occurrence of myelodysplasia and acute megakaryocytic leukemia type 7. C1 [Tallaj, Jose A.; Pamboukian, Salpy V.; Bourge, Robert C.; Cadeiras, Martin; Smallfield, Melissa] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA. [Tallaj, Jose A.] Birmingham VA Med Ctr, Dept Med, Birmingham, AL USA. [George, James F.; Brown, Robert N.; Pajaro, Octavio E.; Kirklin, James K.; McGiffin, David C.] Univ Alabama Birmingham, Dept Med, Div Cardiothorac Surg, Birmingham, AL 35294 USA. RP Tallaj, JA (reprint author), Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, THT331,1900 Univ Blvd, Birmingham, AL 35294 USA. EM jtallaj@uab.edu NR 30 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 EI 1534-6080 J9 TRANSPLANTATION JI Transplantation PD NOV 27 PY 2011 VL 92 IS 10 BP 1159 EP 1164 DI 10.1097/TP.0b013e318231e9d3 PG 6 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 845BP UT WOS:000296798100021 PM 22015463 ER PT J AU Chonghaile, TN Sarosiek, KA Vo, TT Ryan, JA Tammareddi, A Moore, VD Deng, J Anderson, KC Richardson, P Tai, YT Mitsiades, CS Matulonis, UA Drapkin, R Stone, R DeAngelo, DJ McConkey, DJ Sallan, SE Silverman, L Hirsch, MS Carrasco, DR Letai, A AF Chonghaile, Triona Ni Sarosiek, Kristopher A. Thanh-Trang Vo Ryan, Jeremy A. Tammareddi, Anupama Moore, Victoria Del Gaizo Deng, Jing Anderson, Kenneth C. Richardson, Paul Tai, Yu-Tzu Mitsiades, Constantine S. Matulonis, Ursula A. Drapkin, Ronny Stone, Richard DeAngelo, Daniel J. McConkey, David J. Sallan, Stephen E. Silverman, Lewis Hirsch, Michelle S. Carrasco, Daniel Ruben Letai, Anthony TI Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy SO SCIENCE LA English DT Article ID CHRONIC LYMPHOCYTIC-LEUKEMIA; MULTIPLE-MYELOMA CELLS; IN-VIVO; APOPTOSIS; PROLIFERATION; INHIBITOR; PROTEINS; THERAPY; DEATH; LENALIDOMIDE AB Cytotoxic chemotherapy targets elements common to all nucleated human cells, such as DNA and microtubules, yet it selectively kills tumor cells. Here we show that clinical response to these drugs correlates with, and may be partially governed by, the pretreatment proximity of tumor cell mitochondria to the apoptotic threshold, a property called mitochondrial priming. We used BH3 profiling to measure priming in tumor cells from patients with multiple myeloma, acute myelogenous and lymphoblastic leukemia, and ovarian cancer. This assay measures mitochondrial response to peptides derived from proapoptotic BH3 domains of proteins critical for death signaling to mitochondria. Patients with highly primed cancers exhibited superior clinical response to chemotherapy. In contrast, chemoresistant cancers and normal tissues were poorly primed. Manipulation of mitochondrial priming might enhance the efficacy of cytotoxic agents. C1 [Chonghaile, Triona Ni; Sarosiek, Kristopher A.; Thanh-Trang Vo; Ryan, Jeremy A.; Tammareddi, Anupama; Deng, Jing; Anderson, Kenneth C.; Richardson, Paul; Tai, Yu-Tzu; Mitsiades, Constantine S.; Matulonis, Ursula A.; Drapkin, Ronny; Stone, Richard; DeAngelo, Daniel J.; Carrasco, Daniel Ruben; Letai, Anthony] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. [Moore, Victoria Del Gaizo] Elon Univ, Dept Chem, Elon, NC 27244 USA. [McConkey, David J.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA. [Thanh-Trang Vo] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA. [Drapkin, Ronny; Hirsch, Michelle S.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Sallan, Stephen E.; Silverman, Lewis] Childrens Hosp Boston, Dana Farber Canc Inst, Dept Pediat Hematol Oncol, Boston, MA 02215 USA. RP Letai, A (reprint author), Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave, Boston, MA 02215 USA. EM anthony_letai@dfci.harvard.edu RI Ni Chonghaile, Triona/L-9418-2015; Drapkin, Ronny/E-9944-2016; OI Ni Chonghaile, Triona/0000-0002-3041-4031; Drapkin, Ronny/0000-0002-6912-6977; Del Gaizo Moore, Victoria/0000-0002-6317-7693 FU Multiple Myeloma Research Foundation; American Cancer Society [121360-PF-11-256-01-TBG]; Dana-Farber Cancer Institute; Gabrielle's Angel Foundation for Cancer Research; FLAMES Fund of the Pan-Mass Challenge; NIH [RO1CA129974, P01CA068484, P01CA139980] FX We thank I. Galinsky, J. Feather, R. Berkowitz, N. Horowitz, C. Feltmate, M. Muto, E. Kantoff, K. Daniels, and C. Doyle for assistance with human tumor sample procurement; K.-K. Wong and T. Mitchison for critical review; and K. Stevenson for help with biostatistical analysis. We thank Abbott Laboratories for providing ABT-737. We gratefully acknowledge funding from the Multiple Myeloma Research Foundation (T. N. C.), American Cancer Society Postdoctoral Fellowship 121360-PF-11-256-01-TBG (K. A. S.), Women's Cancers Program at the Dana-Farber Cancer Institute (K. A. S.), Gabrielle's Angel Foundation for Cancer Research (T.-T.V.), FLAMES Fund of the Pan-Mass Challenge, and NIH grants RO1CA129974, P01CA068484, and P01CA139980. A. L. is a Leukemia and Lymphoma Society Scholar. A. L. is a cofounder of and a paid advisor to Eutropics Pharmaceuticals, which has purchased a license for BH3 profiling from Dana-Farber Cancer Institute. P. R. is a paid advisor to Millennium Pharmaceuticals, Celgene Corporation, Novartis Pharmaceuticals, Johnson & Johnson, and Bristol Myers Squibb. T. N. C. and J. A. R. are paid consultants to Eutropics Pharmaceuticals. R. D. is a paid consultant for Novartis Pharmaceuticals and Forma Therapeutics. C. S. M. is a paid consultant for Millennium, Celgene, Novartis, Bristol-Myers Squibb, Merck & Co., Kosan Pharmaceuticals, Pharmion, Centocor, and Amnis Therapeutics. The authors (A. L.) and Dana-Farber Cancer Institute have applied for a patent relating to the use of BH3 profiling in predicting chemosensitivity. NR 31 TC 63 Z9 64 U1 2 U2 20 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD NOV 25 PY 2011 VL 334 IS 6059 BP 1129 EP 1133 DI 10.1126/science.1206727 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 852AF UT WOS:000297313900050 ER PT J AU Czupryn, A Zhou, YD Chen, X McNay, D Anderson, MP Flier, JS Macklis, JD AF Czupryn, Artur Zhou, Yu-Dong Chen, Xi McNay, David Anderson, Matthew P. Flier, Jeffrey S. Macklis, Jeffrey D. TI Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice SO SCIENCE LA English DT Article ID ARCUATE NUCLEUS; GLUCOSE-HOMEOSTASIS; PROOPIOMELANOCORTIN NEURONS; ENERGY-BALANCE; POMC NEURONS; BODY-WEIGHT; RECEPTOR; NEUROGENESIS; CHANNELS; PROGENITORS AB Evolutionarily old and conserved homeostatic systems in the brain, including the hypothalamus, are organized into nuclear structures of heterogeneous and diverse neuron populations. To investigate whether such circuits can be functionally reconstituted by synaptic integration of similarly diverse populations of neurons, we generated physically chimeric hypothalami by microtransplanting small numbers of embryonic enhanced green fluorescent protein-expressing, leptin-responsive hypothalamic cells into hypothalami of postnatal leptin receptor-deficient (db/db) mice that develop morbid obesity. Donor neurons differentiated and integrated as four distinct hypothalamic neuron subtypes, formed functional excitatory and inhibitory synapses, partially restored leptin responsiveness, and ameliorated hyperglycemia and obesity in db/db mice. These experiments serve as a proof of concept that transplanted neurons can functionally reconstitute complex neuronal circuitry in the mammalian brain. C1 [Zhou, Yu-Dong; Anderson, Matthew P.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA. [Zhou, Yu-Dong; Anderson, Matthew P.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02215 USA. [Zhou, Yu-Dong; Anderson, Matthew P.] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02215 USA. [Zhou, Yu-Dong; Anderson, Matthew P.] Beth Israel Deaconess Med Ctr, Ctr Life Sci, Boston, MA 02215 USA. [Czupryn, Artur; Macklis, Jeffrey D.] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA. [Czupryn, Artur; Macklis, Jeffrey D.] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA. [Czupryn, Artur; Macklis, Jeffrey D.] Harvard Univ, Sch Med, Dept Neurol, MGH HMS Ctr Nervous Syst Repair, Boston, MA 02114 USA. [Czupryn, Artur; Macklis, Jeffrey D.] Harvard Univ, Sch Med, Dept Neurosurg, MGH HMS Ctr Nervous Syst Repair, Boston, MA 02114 USA. [Czupryn, Artur; Macklis, Jeffrey D.] Massachusetts Gen Hosp, Nayef Al Rodhan Labs, Boston, MA 02114 USA. [Czupryn, Artur] M Nencki Inst Expt Biol, Dept Mol & Cellular Neurobiol, PL-02093 Warsaw, Poland. [Chen, Xi; McNay, David; Flier, Jeffrey S.] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA. RP Anderson, MP (reprint author), Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA. EM matthew_anderson@bidmc.harvard.edu; jeffrey_flier@hms.harvard.edu; jeffrey_macklis@hms.harvard.edu FU NIH [NS41590]; Jane and Lee Seidman Fund for Central Nervous System Research; Emily and Robert Pearlstein Fund for Nervous System Repair; National Institute of Neurological Disorders and Stroke (NINDS) [NS057444, NS054674, NS070295]; Ministerstwa Nauki i Szkolnictwa Wyzszego [N303 298437]; Foundation for Polish Science; [DKR37-28082] FX We thank T. Yamamoto, K. Billmers, A. Palmer, L. Pasquina, K. Quinn, A. Wheeler, and P. Davis (J.D.M. laboratory), and H. Yin (J.S.F. laboratory) for excellent technical assistance. We thank O.K. Ronnekleiv at Oregon Health and Science University for providing antibody to beta-endorphin. We thank M. McKee of the MGH Microscopy Core for excellent EM assistance. This study was partially supported by NIH grant NS41590 (to J.D.M.), with additional infrastructure supported by NS45523 and NS49553 (to J.D.M.), and with additional support from the Jane and Lee Seidman Fund for Central Nervous System Research and the Emily and Robert Pearlstein Fund for Nervous System Repair (to J.D.M.), grant DKR37-28082 (to J.S.F.), the Picower Foundation (to J.S.F. and M. P. A.), National Institute of Neurological Disorders and Stroke (NINDS) grants NS057444, NS054674, and NS070295 (to M. P. A.), and the Nancy Lurie Marks Family Foundation (to M. P. A.). A. C. was partially supported by Ministerstwa Nauki i Szkolnictwa Wyzszego grant N303 298437 and by the Foundation for Polish Science. NR 33 TC 29 Z9 29 U1 2 U2 19 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD NOV 25 PY 2011 VL 334 IS 6059 BP 1133 EP 1137 DI 10.1126/science.1209870 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 852AF UT WOS:000297313900051 PM 22116886 ER PT J AU Shen, Q Huang, SL Du, F Duong, TQ AF Shen, Qiang Huang, Shiliang Du, Fang Duong, Timothy Q. TI Probing ischemic tissue fate with BOLD fMRI of brief oxygen challenge SO BRAIN RESEARCH LA English DT Article DE MRI; Perfusion; Diffusion; Oxygen inhalation; Penumbra ID CEREBRAL-BLOOD-FLOW; FUNCTIONAL MRI; QUANTITATIVE PREDICTION; FOCAL ISCHEMIA; PERFUSION; HYPEROXIA; DIFFUSION; PENUMBRA; STROKE; RATS AB It has been recently shown that at-risk tissue exhibits exaggerated T*(2)-weighted MRI signal increases during transient oxygen challenge (OC), suggesting that the tissue is still metabolically active. This study further characterized the effects of transient OC on T*(2)-weighted MRI in permanent focal stroke rats (N=8) using additional quantitative measures. The major findings were: i) the ischemic core cluster showed no significant response, whereas the mismatch cluster showed markedly higher percent changes relative to normal tissue in the acute phase. ii) Many of the mismatch pixels showed exaggerated OC responses which became hyperintense on T(2)-weighted MRI at 24 h. The area with exaggerated OC responses was larger than the mismatch, suggesting that some tissue with reduced diffusion were potentially at risk. iii) Basal T*(2)-weighted intensities on the perfusion-diffusion contourplot were high in normal tissue and low in the core, with a sharp transition in the mismatch. iv) OC-induced changes on the perfusion-diffusion contourplot dropped as perfusion and diffusion values fell below their respective viability thresholds. v) Basal T(1) increased slightly in the ischemic core (P<0.05). OC decreased T(1) in normal (P<0.05) but not in mismatch and core pixels. vi) OC decreased CBF in normal (P<0.05) but not in mismatch and core pixels. T*(2)-weighted MRI of OC has the potential to offer unique clinically relevant data. (C) 2011 Elsevier B.V. All rights reserved. C1 [Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, Dept Ophthalmol Radiol & Physiol, San Antonio, TX 78229 USA. S Texas Vet Hlth Care Syst, Res Serv, San Antonio, TX USA. RP Duong, TQ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, Dept Ophthalmol Radiol & Physiol, 8403 Floyd Curl Dr, San Antonio, TX 78229 USA. EM duongt@uthscsa.edu RI Duong, Timothy/B-8525-2008; Shen, Qiang/B-8784-2008; Huang, Shiliang/F-3143-2010 OI Shen, Qiang/0000-0002-4287-3403; FU NIH [R01-NS45879]; American Heart Association [ELA 0940104 N, SDG 0830293 N]; Clinical and Translational Science Awards [UL1RR025767] FX This work was supported by the NIH (R01-NS45879), the American Heart Association (EIA 0940104 N and SDG 0830293 N) and Clinical and Translational Science Awards (parent grant UL1RR025767). NR 28 TC 17 Z9 18 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD NOV 24 PY 2011 VL 1425 BP 132 EP 141 DI 10.1016/j.brainres.2011.09.052 PG 10 WC Neurosciences SC Neurosciences & Neurology GA 862VN UT WOS:000298122300014 PM 22032876 ER PT J AU Rousseau, J Gagne, V Labuda, M Beaubois, C Sinnett, D Laverdiere, C Moghrabi, A Sallan, SE Silverman, LB Neuberg, D Kutok, JL Krajinovic, M AF Rousseau, Julie Gagne, Vincent Labuda, Malgorzata Beaubois, Cyrielle Sinnett, Daniel Laverdiere, Caroline Moghrabi, Albert Sallan, Stephen E. Silverman, Lewis B. Neuberg, Donna Kutok, Jeffery L. Krajinovic, Maja TI ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia SO BLOOD LA English DT Article ID ASPARAGINE SYNTHETASE EXPRESSION; MESSENGER-RNA; CELL-LINES; GENE; RESISTANCE; CANCER; IDENTIFICATION; TRANSCRIPTION; CHEMOTHERAPY; REGION AB Asparaginase is a standard and critical component in the therapy of childhood acute lymphoblastic leukemia. Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) and arginosuccinate synthase 1 (ASS1) have been shown to mediate the antileukemic effect of asparaginase and to display variable expression between leukemia cells that are resistant and sensitive to treatment. Fourteen polymorphisms in the regulatory and coding regions of these genes were investigated for an association with acute lymphoblastic leukemia outcome. Lower event-free survival (EFS) was associated with ATF5 T1562C, tandem-repeat ASNS polymorphism, derived haplotype, and ASS1 G1343T and G34T substitutions (P <= .03). Associations were limited to patients who received Escherichia coli asparaginase. Variations that sustained correction for multiple testing (ATF5 T1562C, P = .005; ASNS tandem-repeat and related haplotype, P <= .01) were subsequently analyzed in the replication cohort. The E coli-dependent association of the ATF5 T1562 allele with reduced EFS was confirmed (P = .01). A gene-reporter assay showed that the haplotype tagged by T1562 had higher promoter activity (P <= .01). The remaining regulatory polymorphisms also appeared to affect ATF5 function; 2 additional high-activity haplotypes were identified (P <= .02) and were further corroborated by quantitative mRNA analysis in lymphoblastoid cell lines. The ATF5-regulated increase in ASNS expression in response to more efficacious E coli-induced asparagine depletion may explain our observed results. (Blood. 2011;118(22):5883-5890) C1 [Rousseau, Julie; Gagne, Vincent; Labuda, Malgorzata; Beaubois, Cyrielle; Sinnett, Daniel; Laverdiere, Caroline; Moghrabi, Albert; Krajinovic, Maja] CHU St Justine, Ctr Rech, Montreal, PQ H3T 1C5, Canada. [Sinnett, Daniel; Laverdiere, Caroline; Moghrabi, Albert; Krajinovic, Maja] Univ Montreal, Dept Pediat, Montreal, PQ H3C 3J7, Canada. [Sallan, Stephen E.; Silverman, Lewis B.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Sallan, Stephen E.; Silverman, Lewis B.] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA. [Neuberg, Donna] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Kutok, Jeffery L.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Krajinovic, Maja] Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada. RP Krajinovic, M (reprint author), CHU St Justine, Ctr Rech, 3175 Chemin Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada. EM maja.krajinovic@umontreal.ca FU Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada; Charles Bruneau Foundation; Center d'excellence en Oncologie pediatrique et en soins palliatifs; National Cancer Institute/National Institutes of Health [P01 CA 68484] FX Canadian Institutes of Health Research, Leukemia and Lymphoma Society of Canada, Charles Bruneau Foundation, and Center d'excellence en Oncologie pediatrique et en soins palliatifs supported this study. Dana-Farber Cancer Institute ALL treatment protocols are supported by a National Cancer Institute/National Institutes of Health grant (P01 CA 68484). M.K. and D.S. are scholars of the Fonds de la Recherche en Sante du Quebec. The gene-reporter assay was carried out in part within the Genome Quebec/Genome Canada: Gene Regulators in Disease project. NR 38 TC 19 Z9 20 U1 1 U2 6 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 24 PY 2011 VL 118 IS 22 BP 5883 EP 5890 DI 10.1182/blood-2011-05-355560 PG 8 WC Hematology SC Hematology GA 855PL UT WOS:000297576600028 PM 21972289 ER PT J AU Hu, Z Van Rooijen, N Yang, YG AF Hu, Zheng Van Rooijen, Nico Yang, Yong-Guang TI Macrophages prevent human red blood cell reconstitution in immunodeficient mice SO BLOOD LA English DT Article ID HEMATOPOIETIC GROWTH-FACTORS; COLONY-STIMULATING FACTOR; RECOMBINANT HUMAN INTERLEUKIN-3; INTEGRIN-ASSOCIATED PROTEIN; HUMAN IMMUNE-SYSTEM; STEM-CELLS; MOUSE MODEL; XENOGRAFT REJECTION; PROGENITOR CELLS; BONE-MARROW AB An animal model supporting human erythropoiesis will be highly valuable for assessing the biologic function of human RBCs under physiologic and disease settings, and for evaluating protocols of in vitro RBC differentiation. Herein, we analyzed human RBC reconstitution in NOD/SCID or NOD/SCID/gamma c(-/-) mice that were transplanted with human CD34(+) fetal liver cells and fetal thymic tissue. Although a large number of human CD45(-)CD71(+) nucleated immature erythroid cells were detected in the bone marrow, human RBCs were undetectable in the blood of these mice. Human RBCs became detectable in blood after macrophage depletion but disappeared again after withdrawal of treatment. Furthermore, treatment with human erythropoietin and IL-3 significantly increased human RBC reconstitution in macrophage-depleted, but not control, humanized mice. Significantly more rapid rejection of human RBCs than CD47-deficient mouse RBCs indicates that mechanisms other than insufficient CD47-SIRP alpha signaling are involved in human RBC xenorejection in mice. All considered, our data demonstrate that human RBCs are highly susceptible to rejection by macrophages in immunodeficient mice. Thus, strategies for preventing human RBC rejection by macrophages are required for using immunodeficient mice as an in vivo model to study human erythropoiesis and RBC function. (Blood. 2011;118(22):5938-5946) C1 [Hu, Zheng; Yang, Yong-Guang] Columbia Univ Coll Phys & Surg, Columbia Ctr Translat Immunol, New York, NY 10032 USA. [Hu, Zheng] Univ Sci & Technol China, Inst Immunol, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China. [Hu, Zheng] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China. [Hu, Zheng; Yang, Yong-Guang] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Transplantat Biol Res Ctr, Boston, MA USA. [Van Rooijen, Nico] Vrije Univ Amsterdam, Dept Cell Biol, Amsterdam, Netherlands. RP Yang, YG (reprint author), Columbia Univ Coll Phys & Surg, Columbia Ctr Translat Immunol, 650 W 168th St,BB1501, New York, NY 10032 USA. EM yy2324@columbia.edu FU National Institutes of Health [RC1 HL100117, PO1 CA111519, R01 AI064569] FX This work was supported by the National Institutes of Health (grants RC1 HL100117, PO1 CA111519, and R01 AI064569). NR 48 TC 41 Z9 43 U1 0 U2 8 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 24 PY 2011 VL 118 IS 22 BP 5938 EP 5946 DI 10.1182/blood-2010-11-321414 PG 9 WC Hematology SC Hematology GA 855PL UT WOS:000297576600035 PM 21926352 ER PT J AU McNaughton-Collins, MF Barry, MJ AF McNaughton-Collins, Mary F. Barry, Michael J. TI One Man at a Time - Resolving the PSA Controversy SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material C1 [McNaughton-Collins, Mary F.] Harvard Univ, Sch Med, Boston, MA 02115 USA. Massachusetts Gen Hosp, Boston, MA 02114 USA. RP McNaughton-Collins, MF (reprint author), Harvard Univ, Sch Med, Boston, MA 02115 USA. NR 5 TC 43 Z9 45 U1 0 U2 2 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 24 PY 2011 VL 365 IS 21 BP 1951 EP 1953 DI 10.1056/NEJMp1111894 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 851PF UT WOS:000297282600003 PM 22029758 ER PT J AU Senecal, EL Rosenfield, K Caldera, AE Passeri, JJ AF Senecal, Emily L. Rosenfield, Kenneth Caldera, Angel E. Passeri, Jonathan J. TI Case 36-2011: A 93-Year-Old Woman with Shortness of Breath and Chest Pain SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID ACUTE MYOCARDIAL-INFARCTION; ACUTE AORTIC DISSECTION; EARLY REPOLARIZATION; THROMBOLYTIC THERAPY; ST ELEVATION; ELECTROCARDIOGRAM; CARDIOMYOPATHY; ASSOCIATION C1 [Senecal, Emily L.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [Rosenfield, Kenneth; Caldera, Angel E.; Passeri, Jonathan J.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Senecal, Emily L.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Rosenfield, Kenneth; Caldera, Angel E.; Passeri, Jonathan J.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. RP Senecal, EL (reprint author), Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. NR 19 TC 1 Z9 1 U1 0 U2 2 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 24 PY 2011 VL 365 IS 21 BP 2021 EP 2028 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 851PF UT WOS:000297282600013 PM 22111721 ER PT J AU Bokov, AF Garg, N Ikeno, Y Thakur, S Musi, N DeFronzo, RA Zhang, N Erickson, RC Gelfond, J Hubbard, GB Adamo, ML Richardson, A AF Bokov, Alex F. Garg, Neha Ikeno, Yuji Thakur, Sachin Musi, Nicolas DeFronzo, Ralph A. Zhang, Ning Erickson, Rebecca C. Gelfond, Jon Hubbard, Gene B. Adamo, Martin L. Richardson, Arlan TI Does Reduced IGF-1R Signaling in Igf1r(+/-) Mice Alter Aging? SO PLOS ONE LA English DT Article ID GROWTH-FACTOR-I; LIFE-SPAN EXTENSION; FATAL NEOPLASTIC DISEASES; AMES DWARF MICE; INSULIN-RECEPTOR; CAENORHABDITIS-ELEGANS; CALORIE RESTRICTION; DELAYED OCCURRENCE; LONGEVITY; GENE AB Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased longevity in various invertebrate models. Therefore, the effect of the haplo-insufficiency of the IGF-1 receptor (Igf1r(+/-)) on longevity/aging was evaluated in C57Bl/6 mice using rigorous criteria where lifespan and end-of-life pathology were measured under optimal husbandry conditions using large sample sizes. Igf1r(+/-) mice exhibited reductions in IGF-1 receptor levels and the activation of Akt by IGF-1, with no compensatory increases in serum IGF-1 or tissue IGF-1 mRNA levels, indicating that the Igf1r(+/-) mice show reduced IGF-1 signaling. Aged male, but not female Igf1r(+/-) mice were glucose intolerant, and both genders developed insulin resistance as they aged. Female, but not male Igf1r(+/-) mice survived longer than wild type mice after lethal paraquat and diquat exposure, and female Igf1r(+/-) mice also exhibited less diquat-induced liver damage. However, no significant difference between the lifespans of the male Igf1r(+/-) and wild type mice was observed; and the mean lifespan of the Igf1r(+/-) females was increased only slightly (less than 5%) compared to wild type mice. A comprehensive pathological analysis showed no significant difference in end-of-life pathological lesions between the Igf1r(+/-) and wild type mice. These data show that the Igf1r(+/-) mouse is not a model of increased longevity and delayed aging as predicted by invertebrate models with mutations in the insulin/IGF-1 signaling pathway. C1 [Bokov, Alex F.; Ikeno, Yuji; Musi, Nicolas; Gelfond, Jon; Hubbard, Gene B.; Adamo, Martin L.; Richardson, Arlan] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. [Bokov, Alex F.; Richardson, Arlan] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA. [Garg, Neha; Thakur, Sachin; Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Gelfond, Jon] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Ikeno, Yuji; Hubbard, Gene B.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Musi, Nicolas; DeFronzo, Ralph A.; Zhang, Ning] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Ikeno, Yuji; Musi, Nicolas; Richardson, Arlan] S Texas Vet Hlth Care Syst, GRECC, San Antonio, TX USA. [Erickson, Rebecca C.] Univ Texas Austin, Coll Nat Sci, Austin, TX 78712 USA. RP Bokov, AF (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. EM Richardson@uthscsa.edu FU National Institutes of Health (NIH) [AGO-21890]; Beeson Career Development Award [AG-030979, DK-80157, DK-089229, DK-24092 RAD, R01AG026012, AG-19316, AG-13319, AG-23843, AG-26557]; Nathan Shock [1P30-AG-13319]; Department of Veteran's Affairs; University of Texas System FX This work was supported by National Institutes of Health (NIH) (http://grants.nih.gov/grants/oer.htm) AGO-21890 to AFB; AG-030979 (Beeson Career Development Award), DK-80157 and DK-089229 to NM; DK-24092 RAD; R01AG026012 to MLA; AG-19316, AG-13319, AG-23843, and AG-26557 to AR; Nathan Shock: 1P30-AG-13319 to AR; Department of Veteran's Affairs: Research Enhancement Award Program, Merit Grant to AR; and University of Texas System's Graduate Programs Initiative: Translational Science Training (TST) Across Disciplines to NG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 47 Z9 48 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 23 PY 2011 VL 6 IS 11 AR e26891 DI 10.1371/journal.pone.0026891 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KL UT WOS:000298162000007 PM 22132081 ER PT J AU Prabhakaran, V Rypma, B Narayanan, NS Meier, TB Austin, BP Nair, VA Naing, L Thomas, LE Gabrieli, JDE AF Prabhakaran, Vivek Rypma, Bart Narayanan, Nandakumar S. Meier, Timothy B. Austin, Benjamin P. Nair, Veena A. Naing, Lin Thomas, Lisa E. Gabrieli, John D. E. TI Capacity-Speed Relationships in Prefrontal Cortex SO PLOS ONE LA English DT Article ID WORKING-MEMORY CAPACITY; GENERAL INTELLIGENCE; CORTICAL ACTIVITY; AGE-DIFFERENCES; ADULT AGE; INFORMATION; SPAN; MAINTENANCE; PERFORMANCE; STRATEGIES AB Working memory (WM) capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this interdependence has not been elucidated. We have carried out two functional MRI studies to separately identify brain regions involved in capacity and speed. Experiment 1, using a block-design WM verbal task, identified increased WM capacity with increased activity in right prefrontal regions, and Experiment 2, using a single-trial WM verbal task, identified increased WM processing speed with increased activity in similar regions. Our results suggest that right prefrontal areas may be a common region interlinking these two cognitive measures. Moreover, an overlap analysis with regions associated with binding or chunking suggest that this strategic memory consolidation process may be the mechanism interlinking WM capacity and WM speed. C1 [Prabhakaran, Vivek; Meier, Timothy B.] Univ Wisconsin, Neurosci Training Program, Madison, WI 53715 USA. [Prabhakaran, Vivek; Naing, Lin] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA. [Rypma, Bart] Univ Texas Dallas, Ctr Brain Hlth, Dallas, TX 75230 USA. [Narayanan, Nandakumar S.] Yale Univ, Dept Neurol, New Haven, CT USA. [Austin, Benjamin P.] Univ Wisconsin, Cardiovasc Res Ctr, Madison, WI USA. [Thomas, Lisa E.] Brigham & Womens Hosp, Dept Emergency Med, Boston, MA 02115 USA. [Thomas, Lisa E.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Gabrieli, John D. E.] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA. RP Prabhakaran, V (reprint author), Univ Wisconsin, Neurosci Training Program, Madison, WI 53715 USA. EM vprabhakaran@uwhealth.org RI Vasudevan, prabhakaran/C-7240-2012; Nair, Veena/E-4037-2013; OI NAIR, VEENA/0000-0002-5666-3239 FU National Center for Research Resources (NCRR), National Institutes of Health (NIH) [UL1RR025011]; NIH [RO1 DC05375]; Coulter Foundation; NIH NIMH [RC1MH090912-01] FX Supported by grants UL1RR025011 from the Clinical and Translational Science Award (CTSA) program of the National Center for Research Resources (NCRR), National Institutes of Health (NIH), NIH RO1 DC05375, Coulter Foundation, and RC1MH090912-01 NIH NIMH Challenge Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 8 Z9 8 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 23 PY 2011 VL 6 IS 11 AR e27504 DI 10.1371/journal.pone.0027504 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KL UT WOS:000298162000022 PM 22132105 ER PT J AU Wang, JH Reinherz, EL AF Wang, Jia-huai Reinherz, Ellis L. TI A New Angle on TCR Activation SO IMMUNITY LA English DT Editorial Material ID T-CELL-RECEPTOR; COMPLEX AB Functional cognate T cell recognition is mediated via the interaction of a T cell receptor complex with its pMHC ligand. Adams et al. (2011) in this issue of Immunity provide evidence that docking geometry may impact 2D binding and T cell activation. C1 [Wang, Jia-huai; Reinherz, Ellis L.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Immunobiol Lab, Boston, MA 02115 USA. [Wang, Jia-huai] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Reinherz, Ellis L.] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. RP Reinherz, EL (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Immunobiol Lab, 44 Binney St, Boston, MA 02115 USA. EM ellis_reinherz@dfci.harvard.edu FU NHLBI NIH HHS [P01 HL103526]; NIAID NIH HHS [U01 AI090043, R37 AI019807] NR 10 TC 4 Z9 4 U1 0 U2 2 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-7613 J9 IMMUNITY JI Immunity PD NOV 23 PY 2011 VL 35 IS 5 BP 658 EP 660 DI 10.1016/j.immuni.2011.11.008 PG 3 WC Immunology SC Immunology GA 852XM UT WOS:000297390800003 PM 22118519 ER PT J AU Guinan, EC Barbon, CM Kalish, LA Parmar, K Kutok, J Mancuso, CJ Stoler-Barak, L Suter, EE Russell, JD Palmer, CD Gallington, LC Voskertchian, A Vergilio, JA Cole, G Zhu, KY D'Andrea, A Soiffer, R Weiss, JP Levy, O AF Guinan, Eva C. Barbon, Christine M. Kalish, Leslie A. Parmar, Kalindi Kutok, Jeff Mancuso, Christy J. Stoler-Barak, Liat Suter, Eugenie E. Russell, Janice D. Palmer, Christine D. Gallington, Leighanne C. Voskertchian, Annie Vergilio, Jo-Anne Cole, Geoffrey Zhu, Kaya D'Andrea, Alan Soiffer, Robert Weiss, Jerrold P. Levy, Ofer TI Bactericidal/Permeability-Increasing Protein (rBPI(21)) and Fluoroquinolone Mitigate Radiation-Induced Bone Marrow Aplasia and Death SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID HOST-DISEASE; MICE; INHIBITION; ACTIVATION; PROTECTION; INFECTION; ENDOTOXIN; SURVIVAL; MODELS; INJURY AB Identification of safe, effective treatments to mitigate toxicity after extensive radiation exposure has proven challenging. Only a limited number of candidate approaches have emerged, and the U. S. Food and Drug Administration has yet to approve any agent for a mass-casualty radiation disaster. Because patients undergoing hematopoietic stem cell transplantation undergo radiation treatment that produces toxicities similar to radiation-disaster exposure, we studied patients early after such treatment to identify new approaches to this problem. Patients rapidly developed endotoxemia and reduced plasma bactericidal/permeability-increasing protein (BPI), a potent endotoxin-neutralizing protein, in association with neutropenia. We hypothesized that a treatment supplying similar endotoxin-neutralizing activity might replace the BPI deficit and mitigate radiation toxicity and tested this idea in mice. A single 7-Gy radiation dose, which killed 95% of the mice by 30 days, was followed 24 hours later by twice-daily, subcutaneous injections of the recombinant BPI fragment rBPI(21) or vehicle alone for 14 or 30 days, with or without an oral fluoroquinolone antibiotic with broad-spectrum antibacterial activity, including that against endotoxin-bearing Gram-negative bacteria. Compared to either fluoroquinolone alone or vehicle plus fluoroquinolone, the combined rBPI21 plus fluoroquinolone treatment improved survival, accelerated hematopoietic recovery, and promoted expansion of stem and progenitor cells. The observed efficacy of rBPI(21) plus fluoroquinolone initiated 24 hours after lethal irradiation, combined with their established favorable bioactivity and safety profiles in critically ill humans, suggests the potential clinical use of this radiation mitigation strategy and supports its further evaluation. C1 [Guinan, Eva C.; Parmar, Kalindi; Russell, Janice D.; Zhu, Kaya; D'Andrea, Alan] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02215 USA. [Guinan, Eva C.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA. [Guinan, Eva C.; D'Andrea, Alan] Harvard Univ, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA. [Guinan, Eva C.] Childrens Hosp Boston, Div Hematol Oncol, Boston, MA 02115 USA. [Barbon, Christine M.; Voskertchian, Annie; Cole, Geoffrey; Soiffer, Robert] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. [Kalish, Leslie A.] Childrens Hosp Boston, Clin Res Program, Boston, MA 02115 USA. [Kutok, Jeff] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Mancuso, Christy J.; Stoler-Barak, Liat; Suter, Eugenie E.; Palmer, Christine D.; Gallington, Leighanne C.; Levy, Ofer] Childrens Hosp Boston, Div Infect Dis, Boston, MA 02115 USA. [Vergilio, Jo-Anne] Childrens Hosp Boston, Dept Pathol, Boston, MA 02115 USA. [Soiffer, Robert] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. [Weiss, Jerrold P.] Univ Iowa, Inflammat Program, Coralville, IA 52241 USA. [Weiss, Jerrold P.] Univ Iowa, Dept Med, Coralville, IA 52241 USA. [Levy, Ofer] Harvard Univ, Sch Med, Leder Human Biol & Translat Med Program, Boston, MA 02115 USA. [Levy, Ofer] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. RP Guinan, EC (reprint author), Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02215 USA. EM eva_guinan@dfci.harvard.edu RI Gallington, Leighanne/G-9341-2011 OI Gallington, Leighanne/0000-0002-0383-7522 FU Defense Advanced Research Projects Agency [HR001-08-1-0011]; NIH [5R21 HL089659, 5U19 AI067751]; Dana Foundation; G. Green Foundation; Shea Family Fund FX Defense Advanced Research Projects Agency HR001-08-1-0011, NIH 5R21 HL089659 and 5U19 AI067751, the Dana Foundation, the G. Green Foundation, and Shea Family Fund. NR 50 TC 0 Z9 0 U1 1 U2 10 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 J9 SCI TRANSL MED JI Sci. Transl. Med. PD NOV 23 PY 2011 VL 3 IS 110 AR 110ra118 DI 10.1126/scitranslmed.3003126 PG 12 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA 853EA UT WOS:000297407800004 ER PT J AU Pittet, MJ Weissleder, R AF Pittet, Mikael J. Weissleder, Ralph TI Intravital Imaging SO CELL LA English DT Article ID IN-VIVO; DENDRITIC CELLS; LYMPH-NODE; T-CELLS; FLUORESCENT PROTEINS; 2-PHOTON MICROSCOPY; HEMATOPOIETIC STEM; SINGLE CELLS; LIVING CELLS; BONE-MARROW AB Until recently, the idea of observing life deep within the tissues of a living mouse, at a resolution sufficient to pick out cellular behaviors and molecular signals underlying them, remained a much-coveted dream. Now, a new era of intravital fluorescence microscopy has dawned. In this Primer, we review the technologies that made this revolution possible and demonstrate how intravital imaging is beginning to provide quantitative and dynamic insights into cell biology, immunology, tumor biology, and neurobiology. C1 [Pittet, Mikael J.; Weissleder, Ralph] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA. [Pittet, Mikael J.; Weissleder, Ralph] Harvard Univ, Sch Med, Boston, MA 02114 USA. [Weissleder, Ralph] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA. RP Pittet, MJ (reprint author), Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA. EM mpittet@mgh.harvard.edu FU US National Institutes of Health (NIH) [R01-AI084880, P50-CA086355, U54-CA126515]; NIH [P50-CA086355, R01-CA164448] FX We apologize to the authors whose work we could not cite because of the limit on the number of references. We would like to thank Drs. Claudio Vinegoni, Rainer Kohler, Misha Pivovarov, and Martin Etzrodt for valuable comments and data generation; Drs. Thomas Reiner, Sarah Earley, and Katy Yang for some of the examples in Figures 1 and 3; and Dr. Yvonna Fisher-Jeffes for review. Special thanks go to Drs. Charles Lin, Timothy Mitchison, Peter Sorger, and Gaudenz Danuser for helpful discussions. The work of M.J.P. is supported by US National Institutes of Health (NIH) grants R01-AI084880, P50-CA086355, and U54-CA126515. The work of R. W. is supported by NIH grants R01-CA164448 and P50-CA086355. NR 75 TC 157 Z9 157 U1 2 U2 67 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 J9 CELL JI Cell PD NOV 23 PY 2011 VL 147 IS 5 BP 983 EP 991 DI 10.1016/j.cell.2011.11.004 PG 9 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 852SA UT WOS:000297376600012 PM 22118457 ER PT J AU Piskounova, E Polytarchou, C Thornton, JE LaPierre, RJ Pothoulakis, C Hagan, JP Iliopoulos, D Gregory, RI AF Piskounova, Elena Polytarchou, Christos Thornton, James E. LaPierre, Robert J. Pothoulakis, Charalabos Hagan, John P. Iliopoulos, Dimitrios Gregory, Richard I. TI Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms SO CELL LA English DT Article ID HUMAN HEPATOCELLULAR-CARCINOMA; REDUCES TUMOR-GROWTH; EMBRYONIC STEM-CELLS; PROMOTES TRANSFORMATION; MICROPROCESSOR COMPLEX; CAENORHABDITIS-ELEGANS; FEEDBACK LOOP; SELF-RENEWAL; CANCER-CELLS; LIN-28 AB Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase (Zcchc11/TUT4) to let-7 precursors to block processing by Dicer in the cell cytoplasm. Here we find that unlike Lin28A, Lin28B represses let-7 processing through a Zcchc11-independent mechanism. Lin28B functions in the nucleus by sequestering primary let-7 transcripts and inhibiting their processing by the Microprocessor. The inhibitory effects of Zcchc11 depletion on the tumorigenic capacity and metastatic potential of human cancer cells and xenografts are restricted to Lin28A-expressing tumors. Furthermore, the majority of human colon and breast tumors analyzed exclusively express either Lin28A or Lin28B. Lin28A is expressed in HER2-overexpressing breast tumors, whereas Lin28B expression characterizes triple-negative breast tumors. Overall our results illuminate the distinct mechanisms by which Lin28A and Lin28B function and have implications for the development of new strategies for cancer therapy. C1 [Polytarchou, Christos; Iliopoulos, Dimitrios] Harvard Univ, Sch Med, Dept Microbiol & Immunol, Boston, MA 02115 USA. [Piskounova, Elena; Thornton, James E.; LaPierre, Robert J.; Hagan, John P.; Gregory, Richard I.] Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA. [Piskounova, Elena; Thornton, James E.; LaPierre, Robert J.; Hagan, John P.; Gregory, Richard I.] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA. [Piskounova, Elena; Thornton, James E.; LaPierre, Robert J.; Hagan, John P.; Gregory, Richard I.] Harvard Stem Cell Inst, Boston, MA 02115 USA. [Polytarchou, Christos; Iliopoulos, Dimitrios] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA. [Pothoulakis, Charalabos] Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90095 USA. [Hagan, John P.] Ohio State Univ, Med Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA. RP Iliopoulos, D (reprint author), Harvard Univ, Sch Med, Dept Microbiol & Immunol, Boston, MA 02115 USA. EM dimitrios_iliopoulos@dfci.harvard.edu; rgregory@enders.tch.harvard.edu OI Hagan, John/0000-0003-0295-4898 FU US National Institute of General Medical Sciences (NIGMS) [1R01GM086386-01A1]; Harvard Stem Cell Institute; American Cancer Society [121635-RSG-11-175-01-RMC]; Department of Cancer Immunology & AIDS at Dana-Farber Cancer Institute FX We thank Dr. Akihiko Yoshimura, Keio University, Japan, for the human Flag-Zcchc11 plasmid; Dr. Na Liu, Memorial Sloan Kettering Cancer Center, for the Myc-Ago2 plasmid; Dr. Bharat Ramratnam, Brown University, for the GFP-Drosha plasmid; and Dr. Ramin Shiekhattar, Wistar Institute, for the FlagEif6 expression plasmid. We thank Chiara Giacomelli, Dr. Saurabh Patel, and Dr. Maria Hatziapostolou for technical assistance. R. I. G. was supported by grants from the US National Institute of General Medical Sciences (NIGMS) (1R01GM086386-01A1), The Harvard Stem Cell Institute, and The American Cancer Society (121635-RSG-11-175-01-RMC). R. I. G. is a Pew Research Scholar. D. I. was supported by start-up funds from the Department of Cancer Immunology & AIDS at Dana-Farber Cancer Institute. NR 50 TC 217 Z9 230 U1 3 U2 32 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 J9 CELL JI Cell PD NOV 23 PY 2011 VL 147 IS 5 BP 1066 EP 1079 DI 10.1016/j.cell.2011.10.039 PG 14 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 852SA UT WOS:000297376600018 PM 22118463 ER PT J AU Cheriyan, T Schmid, TM Spector, M AF Cheriyan, Thomas Schmid, Thomas M. Spector, Myron TI Presence and distribution of the lubricating protein, lubricin, in the meibomian gland in rabbits SO MOLECULAR VISION LA English DT Article ID SUPERFICIAL ZONE PROTEIN; BOVINE SYNOVIAL-FLUID; ARTICULAR-CARTILAGE; TEAR FILM; HYALURONIC-ACID; MODEL SURFACES; GLYCOPROTEIN; LIPIDS; PROTEOGLYCAN; CHONDROCYTES AB Purpose: Lubricin is a principal boundary lubricating and anti-adhesion protein found in synovial fluid and several musculoskeletal tissues. This study investigates the presence of lubricin in the meibomian gland, lacrimal gland and ocular surface of healthy rabbits; prompted by the hypothesis that lubricin acts as boundary lubricant and anti-adhesive protein in the eye. Methods: Thirty six eyelids were resected from ten cadaveric New Zealand White rabbits and two eyeballs and two lacrimal glands from two of them. Thirty two samples from 8 animals were processed for immunohistochemical localization of lubricin using a purified monoclonal antibody and quantification of the lubricin-containing meibocytes. Confirmatory western blot analysis was performed on four eyelids from 2 animals. Results: Lubricin-positive meibomian cells were seen in the glands in all eight animals evaluated immunohistochemically. The percentage of lubricin-positive cells ranged from was 8%-50% in the upper and 3%-50% in the lower eyelid, with no significant difference between the upper and lower eyelid. Western blot analysis confirmed the presence of lubricin ranging from 10 to 40 ng in four eyelids from the other two rabbits. Occasional staining was seen in the epithelium of the hair follicles of the eyelid. No lubricin was evident on the ocular surface or in the lacrimal gland. Conclusions: Lubricin is secreted by the meibomian gland. The results provide a basis for the hypothesis that lubricin plays a role in boundary lubrication and in preventing adhesions in the eye, as well as in contributing to other functions of the meibomian gland. Moreover, if lubricin functions to decrease the friction between the eyelid and ocular surface, this study provides a rationale to supplement the amount of lubricin in cases of compromised meibomian gland function and other conditions. C1 [Cheriyan, Thomas; Spector, Myron] VA Boston Healthcare Syst, Tissue Engn, Boston, MA 02130 USA. [Cheriyan, Thomas; Spector, Myron] Harvard Univ, Brigham & Womens Hosp, Dept Orthoped Surg, Sch Med, Boston, MA 02115 USA. [Schmid, Thomas M.] Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA. RP Spector, M (reprint author), VA Boston Healthcare Syst, Tissue Engn, Mail Stop 151 Res,150 S Huntington Ave, Boston, MA 02130 USA. EM mspector@rics.bwh.harvard.edu FU U.S Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service; VA Research Career Scientist Award FX The research reported here was supported in part by the U.S Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service. M. Spector is supported by a VA Research Career Scientist Award. NR 40 TC 2 Z9 2 U1 1 U2 3 PU MOLECULAR VISION PI ATLANTA PA C/O JEFF BOATRIGHT, LAB B, 5500 EMORY EYE CENTER, 1327 CLIFTON RD, N E, ATLANTA, GA 30322 USA SN 1090-0535 J9 MOL VIS JI Mol. Vis. PD NOV 23 PY 2011 VL 17 IS 327-30 BP 3055 EP 3061 PG 7 WC Biochemistry & Molecular Biology; Ophthalmology SC Biochemistry & Molecular Biology; Ophthalmology GA 852DM UT WOS:000297328400002 PM 22162624 ER PT J AU Mega, JL Hochholzer, W Frelinger, AL Kluk, MJ Angiolillo, DJ Kereiakes, DJ Isserman, S Rogers, WJ Ruff, CT Contant, C Pencina, MJ Scirica, BM Longtine, JA Michelson, AD Sabatine, MS AF Mega, Jessica L. Hochholzer, Willibald Frelinger, Andrew L., III Kluk, Michael J. Angiolillo, Dominick J. Kereiakes, Dean J. Isserman, Steven Rogers, William J. Ruff, Christian T. Contant, Charles Pencina, Michael J. Scirica, Benjamin M. Longtine, Janina A. Michelson, Alan D. Sabatine, Marc S. TI Dosing Clopidogrel Based on CYP2C19 Genotype and the Effect on Platelet Reactivity in Patients With Stable Cardiovascular Disease SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID PERCUTANEOUS CORONARY INTERVENTION; MAINTENANCE-DOSE CLOPIDOGREL; ST-SEGMENT ELEVATION; CLINICAL-OUTCOMES; GENETIC POLYMORPHISMS; MYOCARDIAL-INFARCTION; ACTIVE METABOLITE; HEALTHY-SUBJECTS; CONTROLLED TRIAL; 150 MG/DAY AB Context Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel. Objective To test whether higher doses (up to 300 mg daily) improve the response to clopidogrel in the setting of loss-of-function CYP2C19 genotypes. Design, Setting, and Patients ELEVATE-TIMI 56 was a multicenter, randomized, double-blind trial that enrolled and genotyped 333 patients with cardiovascular disease across 32 sites from October 2010 until September 2011. Interventions Maintenance doses of clopidogrel for 4 treatment periods, each lasting approximately 14 days, based on genotype. In total, 247 noncarriers of a CYP2C19*2 loss-of-function allele were to receive 75 and 150 mg daily of clopidogrel (2 periods each), whereas 86 carriers (80 heterozygotes, 6 homozygotes) were to receive 75, 150, 225, and 300 mg daily. Main Outcome Measures Platelet function test results (vasodilator-stimulated phosphoprotein [VASP] phosphorylation and VerifyNow P2Y(12) assays) and adverse events. Results With 75 mg daily, CYP2C19*2 heterozygotes had significantly higher on-treatment platelet reactivity than did noncarriers (VASP platelet reactivity index [PRI]: mean, 70.0%; 95% CI, 66.0%-74.0%, vs 57.5%; 95% CI, 55.1%-59.9%, and VerifyNow P2Y(12) reaction units[PRU]: mean, 225.6; 95% CI, 207.7-243.4, vs 163.6; 95% CI, 154.4-173.9; P < .001 for both comparisons). Among CYP2C19*2 heterozygotes, doses up to 300 mg daily significantly reduced platelet reactivity, with VASPPRI decreasing to 48.9%(95% CI, 44.6%-53.2%) and PRU to 127.5(95% CI, 109.9-145.2) (P < .001 for trend across doses for both). Whereas 52% of CYP2C19*2 heterozygotes were nonresponders (>= 230 PRU) with 75 mg of clopidogrel, only 10% were nonresponders with 225 or 300 mg(P < .001 for both). Clopidogrel, 225 mg daily, reduced platelet reactivity in CYP2C19*2 heterozygotes to levels achieved with standard clopidogrel, 75 mg, in noncarriers (mean ratios of platelet reactivity, VASP PRI, 0.92; 90% CI, 0.85-0.99, and PRU, 0.94; 90% CI, 0.84-1.04). In CYP2C19*2 homozygotes, even with 300 mg daily of clopidogrel, mean VASP PRI was 68.3% (95% CI, 44.9%-91.6%) and mean PRU, 287.0 (95% CI, 170.2-403.8). Conclusion Among patients with stable cardiovascular disease, tripling the maintenance dose of clopidogrel to 225 mg daily in CYP2C19*2 heterozygotes achieved levels of platelet reactivity similar to that seen with the standard 75-mg dose in noncarriers; in contrast, for CYP2C19*2 homozygotes, doses as high as 300 mg daily did not result in comparable degrees of platelet inhibition. C1 [Mega, Jessica L.; Ruff, Christian T.; Scirica, Benjamin M.; Sabatine, Marc S.] Brigham & Womens Hosp, Dept Med, Div Cardiovasc, TIMI Study Grp, Boston, MA 02115 USA. [Mega, Jessica L.; Ruff, Christian T.; Scirica, Benjamin M.; Sabatine, Marc S.] Harvard Univ, Sch Med, Boston, MA USA. [Hochholzer, Willibald] Herz Zentrum Bad Krozingen, Bad Krozingen, Germany. [Frelinger, Andrew L., III; Michelson, Alan D.] Childrens Hosp Boston, Ctr Platelet Res Studies, Boston, MA USA. [Kluk, Michael J.; Longtine, Janina A.] Brigham & Womens Hosp, Ctr Adv Mol Diagnost, Dept Pathol, Boston, MA 02115 USA. [Angiolillo, Dominick J.] Univ Florida, Coll Med, Jacksonville, FL USA. [Kereiakes, Dean J.] Childrens Hosp, Heart & Vasc Ctr, Cincinnati, OH 45229 USA. [Isserman, Steven] Clin Trials Amer, Hickory, NC USA. [Rogers, William J.] Univ Alabama, Birmingham Med Ctr, Tuscaloosa, AL 35487 USA. [Pencina, Michael J.] Harvard Clin Res Inst, Boston, MA USA. [Pencina, Michael J.] Boston Univ, Boston, MA 02215 USA. RP Mega, JL (reprint author), Brigham & Womens Hosp, Dept Med, Div Cardiovasc, TIMI Study Grp, Boston, MA 02115 USA. EM jmega@partners.org FU Bristol-Myers Squibb/sanofi-aventis; Eli Lilly; Daiichi Sankyo; Johnson Johnson/Bayer; Nanosphere; GL Synthesis; Takeda; Medicines Company; Portola; Accumetrics; Schering-Plough; AstraZeneca; Eisai; Johnson Johnson; GlaxoSmithKline; Otsuka; James and Esther King Biomedical Research Grant; Merck; Bristol-Myers Squibb; Bayer Healthcare; Gilead; sanofi-aventis; National Institutes of Health [K99/R00 HL098461]; German Heart Foundation FX All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Mega reported receiving research grants from Bristol-Myers Squibb/sanofi-aventis, Eli Lilly, Daiichi Sankyo, and Johnson & Johnson/Bayer, and other research support from Nanosphere and Accumetrics and serving on consultant/advisory boards for Bristol-Myers Squibb, sanofi-aventis, AstraZeneca, Bayer, Novartis, and Merck. Dr Hochholzer reported serving on a consultant/advisory board for sanofi-aventis. Dr Frelinger reported receiving research grants from Bristol-Myers Squibb/sanofi-aventis, Eli Lilly, Daiichi Sankyo, GL Synthesis, and Takeda and serving on a consultant/advisory board for Eli Lilly. Dr Angiolillo reported receiving research grants from Eli Lilly, Daiichi Sankyo, The Medicines Company, Portola, Accumetrics, Schering-Plough, AstraZeneca, Eisai, Johnson & Johnson, Bristol-Myers Squibb/sanofi-aventis, GlaxoSmithKline, and Otsuka; other research support from a James and Esther King Biomedical Research Grant; and honoraria for lectures from Bristol-Myers Squibb, sanofi-aventis, Eli Lilly, and Daiichi Sankyo and serving on consultant/advisory boards for The Medicines Company, Portola, Novartis, Medicure, Accumetrics, Arena Pharmaceuticals, Merck, Evolva, Bristol-Myers Squibb, sanofi-aventis, Eli Lilly, Daiichi Sankyo, Abbott Vascular, and AstraZeneca. Dr Ruff reported receiving a research grant from Bristol-Myers Squibb/sanofi-aventis and Merck and serving on consultant/advisory boards for Daiichi Sankyo, Beckman Coulter, and Alere. Dr Scirica reported receiving research grants from AstraZeneca, Bristol-Myers Squibb, Merck, Johnson & Johnson, Bayer Healthcare, Gilead, and Daiichi Sankyo and serving on consultant/advisory boards for Gilead and AstraZeneca. Dr Michelson reported receiving research grants from Bristol-Myers Squibb/sanofi-aventis, Eli Lilly, Daiichi Sankyo, GL Synthesis, and Takeda and serving on a consultant/advisory board for Eli Lilly. Dr Sabatine reported receiving research grants from AstraZeneca, Bristol-Myers Squibb/sanofi-aventis joint venture, Daiichi Sankyo, sanofi-aventis, and Schering-Plough and other research support from Nanosphere and serving on consultant/advisory boards for AstraZeneca, Bristol-Myers Squibb/sanofi-aventis, Daiichi Sankyo/Eli Lilly, Eli Lilly, and sanofi-aventis. No other disclosures were reported.; The ELEVATE-TIMI 56 trial was funded by an investigator-initiated grant from Bristol-Myers Squibb/sanofi-aventis. Research supplies were provided by Accumetrics and Nanosphere. Dr Mega is supported in part by grant K99/R00 HL098461 from the National Institutes of Health. Dr Hochholzer is supported in part by the German Heart Foundation. NR 31 TC 182 Z9 196 U1 1 U2 14 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 23 PY 2011 VL 306 IS 20 BP 2221 EP 2228 DI 10.1001/jama.2011.1703 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 851GD UT WOS:000297255500021 PM 22088980 ER PT J AU Afilalo, J Flynn, A Agnihotri, AK Castrillo, C Bendayan, M Shahian, DM Picard, MH AF Afilalo, Jonathan Flynn, Aidan Agnihotri, Arvind K. Castrillo, Cristina Bendayan, Melissa Shahian, David M. Picard, Michael H. TI Incremental Value of Routine Preoperative Echocardiography in Patients Undergoing Coronary Artery Bypass Surgery: The Pre-Operative Surgical Stratification by Echocardiography (POSSE) Study SO CIRCULATION LA English DT Meeting Abstract DE Echocardiography; Cardiac surgery; Outcomes; Ischemic heart disease; Aortocoronary bypass C1 [Afilalo, Jonathan; Flynn, Aidan; Agnihotri, Arvind K.; Castrillo, Cristina; Bendayan, Melissa; Shahian, David M.; Picard, Michael H.] Harvard Univ, Massachusetts Gen Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16590 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708088 ER PT J AU Altman, RK Shah, RV Zilinski, J Leyton-Mange, J Orencole, M Anderson, A Heist, EK Barrett, CD Park, MY Picard, MH Das, RK Singh, JP Das, S AF Altman, Robert K. Shah, Ravi V. Zilinski, Jodi Leyton-Mange, Jordan Orencole, Mary Anderson, Amanda Heist, E. Kevin Barrett, Conor D. Park, Mi Young Picard, Michael H. Das, Ranendra K. Singh, Jagmeet P. Das, Saumya TI Predictors of Outcomes Following Cardiac Resynchronization Therapy in Diabetics with Heart Failure: A Prospective Cohort Study SO CIRCULATION LA English DT Meeting Abstract DE CRT; Heart failure; Type 2 Diabetes; Outcomes C1 [Altman, Robert K.; Shah, Ravi V.; Zilinski, Jodi; Leyton-Mange, Jordan; Orencole, Mary; Anderson, Amanda; Heist, E. Kevin; Barrett, Conor D.; Park, Mi Young; Picard, Michael H.; Singh, Jagmeet P.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Das, Ranendra K.] Johns Hopkins Univ, Baltimore, MD USA. [Das, Saumya] Beth Israel Deaconess Med Cntr, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A10331 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738702301 ER PT J AU Altman, RK Orencole, M Parks, KA Moore, SA Park, MY Kumar, P Deeprasertkul, P Truong, QA Schlett, CL Lewis, GD Heist, EK Picard, MH Singh, JP AF Altman, Robert K. Orencole, Mary Parks, Kimberly A. Moore, Stephanie A. Park, Mi Young Kumar, Prabhat Deeprasertkul, Peerawut Truong, Quynh A. Schlett, Christopher L. Lewis, Gregory D. Heist, E. Kevin Picard, Michael H. Singh, Jagmeet P. TI Multidisciplinary Care of Patients Receiving Cardiac Resynchronization Therapy Improves Clinical Outcomes SO CIRCULATION LA English DT Meeting Abstract DE Resynchronization therapy; Heart failure; Patient care; Outcomes; Pacemakers C1 [Altman, Robert K.; Orencole, Mary; Parks, Kimberly A.; Moore, Stephanie A.; Park, Mi Young; Kumar, Prabhat; Deeprasertkul, Peerawut; Truong, Quynh A.; Schlett, Christopher L.; Lewis, Gregory D.; Heist, E. Kevin; Picard, Michael H.; Singh, Jagmeet P.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A8577 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701138 ER PT J AU Angiolillo, DJ Schneider, DJ Bhatt, DL French, WJ Price, MJ Saucedo, JF Shaburishvili, T Huber, K Prats, J Liu, TP Harrington, RA Becker, R AF Angiolillo, Dominick J. Schneider, David J. Bhatt, Deepak L. French, William J. Price, Matthew J. Saucedo, Jorge F. Shaburishvili, Tamaz Huber, Kurt Prats, Jayne Liu, Tiepu Harrington, Robert A. Becker, Richard TI Pharmacodynamic Effects of Cangrelor and Clopidogrel: The Platelet Function Substudy from the Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition in Patients Undergoing Percutaneous Coronary Intervention (CHAMPION-PCI) Trial SO CIRCULATION LA English DT Meeting Abstract DE Cangrelor; Antiplatelet drugs; Drug interactions; Pharmacology; Percutaneous coronary intervention C1 [Angiolillo, Dominick J.] Univ Florida, Dept Med, Div Cardiol, Jacksonville, FL USA. [Schneider, David J.] Univ Vermont, Dept Med, Div Cardiol, Burlington, VT USA. [Bhatt, Deepak L.] Harvard Univ, Brigham & Womens Hosp, Sch Med, VA Boston Healthcare Syst, Boston, MA 02115 USA. [French, William J.] Harbor UCLA Med Ctr, Torrance, CA 90509 USA. [Price, Matthew J.] Scripps Clin, Div Cardiovasc Dis, La Jolla, CA USA. [Saucedo, Jorge F.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Shaburishvili, Tamaz] Diagnost Serv Clin, Tbilisi, Rep of Georgia. [Huber, Kurt] Wilhelminenhospital, Dept Med Cardiol & Emergency Med 3, Vienna, Austria. [Prats, Jayne; Liu, Tiepu] Med Co, Parsippany, NJ USA. [Harrington, Robert A.; Becker, Richard] Duke Univ, Med Ctr, Duke Clin Rsch Inst, Durham, NC USA. NR 0 TC 2 Z9 2 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13354 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705125 ER PT J AU Bagarova, J Paskin-Flerlage, SD Lai, CS Bloch, KD Yu, PB AF Bagarova, Jana Paskin-Flerlage, Samuel D. Lai, Carol S. Bloch, Kenneth D. Yu, Paul B. TI BMP9 Regulates Endothelin-1 Gene Transcription in Cooperation With TGF-beta Signaling SO CIRCULATION LA English DT Meeting Abstract DE Endothelin; Endothelium; Pulmonary hypertension; Gene expression C1 [Bagarova, Jana; Paskin-Flerlage, Samuel D.; Lai, Carol S.; Yu, Paul B.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiol, Boston, MA 02115 USA. [Bloch, Kenneth D.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A17230 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708307 ER PT J AU Baggish, AL Hale, AE Weiner, RB Lewis, GD Systrom, DM Wang, F Wang, TJ Chan, SY AF Baggish, Aaron L. Hale, Andrew E. Weiner, Rory B. Lewis, Gregory D. Systrom, David M. Wang, Francis Wang, Thomas J. Chan, Stephen Y. TI Dynamic Regulation of Circulating MicroRNA During Acute Exhaustive Exercise and Sustained Aerobic Exercise Training SO CIRCULATION LA English DT Meeting Abstract DE Exercise tests; Microrna; Cardiorespiratory fitness; Biomarkers C1 [Baggish, Aaron L.; Weiner, Rory B.; Lewis, Gregory D.; Systrom, David M.; Wang, Thomas J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Hale, Andrew E.; Chan, Stephen Y.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Hale, Andrew E.; Chan, Stephen Y.] Harvard Univ, Sch Med, Boston, MA USA. [Wang, Francis] Harvard Univ Hlth Sci, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A10354 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738702303 ER PT J AU Bair, SM Minamishima, YA Liao, RL Kaelin, WG Moslehi, J AF Bair, Steven M. Minamishima, Yoji A. Liao, Ronglih Kaelin, William G. Moslehi, Javid TI Acute HIF Prolyl Hydroxylase 2 Inactivation Confers Protection Against Myocardial Ischemic Reperfusion Injury SO CIRCULATION LA English DT Meeting Abstract DE Ischemia reperfusion C1 [Bair, Steven M.; Minamishima, Yoji A.; Kaelin, William G.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Liao, Ronglih; Moslehi, Javid] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA. RI Minamishima, Yoji/E-5380-2010 OI Minamishima, Yoji/0000-0001-7995-9318 NR 0 TC 0 Z9 0 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16056 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707285 ER PT J AU Beaudoin, J Handschumacher, MD Hung, J Levine, RA Schwammenthal, E AF Beaudoin, Jonathan Handschumacher, Mark D. Hung, Judy Levine, Robert A. Schwammenthal, Ehud TI Mitral Valve Adaptation in Chronic Aortic Regurgitation with Preserved Systolic Function: A Three-Dimensional Echocardiographic Study SO CIRCULATION LA English DT Meeting Abstract DE Valvular disease; Echocardiography; Mitral regurgitation; Aortic regurgitation C1 [Beaudoin, Jonathan; Handschumacher, Mark D.; Hung, Judy; Levine, Robert A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cardiac Ultrasound Lab, Boston, MA USA. [Schwammenthal, Ehud] Sheba Med Cntr, Inst Prevent Cardiol & Cardiac Rehabil, Tel Hashomer, Israel. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9177 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701288 ER PT J AU Berg, DD Wiviott, SD Sloan, S Kashani, A Gibson, CM Cannon, CP Morrow, D Contant, CF Sabatine, MS Braunwald, E Giugliano, RP AF Berg, David D. Wiviott, Stephen D. Sloan, Sarah Kashani, Amir Gibson, C. Michael Cannon, Christopher P. Morrow, David Contant, Charles F. Sabatine, Marc S. Braunwald, Eugene Giugliano, Robert P. TI Causes and Timing of Death in Patients With NSTE ACS: An Analysis of the TIMI Trials SO CIRCULATION LA English DT Meeting Abstract DE Myocardial infarction, NSTEMI; Acute coronary syndromes; Sudden cardiac death C1 [Berg, David D.; Wiviott, Stephen D.; Sloan, Sarah; Kashani, Amir; Gibson, C. Michael; Cannon, Christopher P.; Morrow, David; Contant, Charles F.; Sabatine, Marc S.; Braunwald, Eugene; Giugliano, Robert P.] Harvard Univ, Brigham & Womens Hosp, TIMI Study Grp, Sch Med,Cardiovasc Div,Dept Med, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16393 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708019 ER PT J AU Berghausen, EM Vantler, M Jannsen, W ten Freyhaus, H Zhao, JJ Schermuly, RT Rosenkranz, S AF Berghausen, Eva M. Vantler, Marius Jannsen, Wiebke ten Freyhaus, Henrik Zhao, Jean J. Schermuly, Ralf T. Rosenkranz, Stephan TI The Catalytic PI 3-Kinase Subunit p110 alpha Represents a Promising Target to Inhibit Vascular Remodeling in Pulmonary Arterial Hypertension SO CIRCULATION LA English DT Meeting Abstract DE Pulmonary hypertension; Growth factors; Vascular disease C1 [Berghausen, Eva M.; Vantler, Marius; ten Freyhaus, Henrik; Rosenkranz, Stephan] Univ Hosp Colonge, Dept Internal Med 3, D-50937 Cologne, Germany. [Jannsen, Wiebke; Schermuly, Ralf T.] Max Planck Inst, Dept Heart & Lung Rsch, D-61231 Bad Nauheim, Germany. [Zhao, Jean J.] Harvard Univ, Dana Farber Canc Inst, Sch Med, Boston, MA 02215 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15487 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707090 ER PT J AU Bhardwaj, A Rehman, SU Mohammed, AA Han-na, K Barajas, L Barajas, J Moore, SA Sullivan, DA Januzzi, JL AF Bhardwaj, Anju Rehman, Shafiq U. Mohammed, Asim A. Han-na, Kim Barajas, Linda Barajas, Justine Moore, Stephanie A. Sullivan, Dorothy A. Januzzi, James L., Jr. TI NT-ProBNP Guided Therapy Improves the Quality of Life in Patients with Chronic Heart Failure. Results From the ProBNP Outpatient Tailored Chronic Heart Failure Therapy Study. SO CIRCULATION LA English DT Meeting Abstract DE Heart failure; Natriuretic peptide; Quality of life C1 [Bhardwaj, Anju; Rehman, Shafiq U.; Mohammed, Asim A.; Han-na, Kim; Barajas, Linda; Barajas, Justine; Moore, Stephanie A.; Sullivan, Dorothy A.; Januzzi, James L., Jr.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13596 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705222 ER PT J AU Britton, K Pedley, A Massaro, J Corsini, E Murabito, JM Hoffmann, U Ingram, C Keaney, J Vasan, R Fox, C AF Britton, Kathryn Pedley, Alison Massaro, Joseph Corsini, Erin Murabito, Joanne M. Hoffmann, Udo Ingram, Cheryl Keaney, John Vasan, Ramachandran Fox, Caroline TI Adipose Tissue Depots and Their Cross-Sectional Association With Circulating Biomarkers of Metabolic Regulation SO CIRCULATION LA English DT Meeting Abstract DE Obesity; Biomarkers; Adipokine; Epidemiology C1 [Britton, Kathryn] Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA. [Pedley, Alison; Murabito, Joanne M.; Vasan, Ramachandran; Fox, Caroline] NHLBI, Framingham Heart Study, Framingham, MA USA. [Massaro, Joseph] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA. [Corsini, Erin; Hoffmann, Udo] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Ingram, Cheryl; Keaney, John] Univ Massachusetts, Sch Med, Div Cardiovasc Med, Worcester, MA USA. [Vasan, Ramachandran] Boston Univ, Dept Med, Cardiol Sect, Framingham, MA USA. [Vasan, Ramachandran] Boston Univ, Dept Med, Sect Prevent Med, Framingham, MA USA. [Fox, Caroline] NHLBI, Div Endocrinol Metab & Hypertens, Framingham, MA USA. [Fox, Caroline] Cntr Populat Studies, Framingham, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12918 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704362 ER PT J AU Buys, ES Raher, MJ Kirby, A Hayton, SR Baron, DM Sips, PY Mohd, S Rauwerdink, KM Yan, QS Tainsh, LT Shakartzi, H Stevens, C Decaluwe, K Van de Voorde, J Wang, T Brouckaert, P Daly, MJ Bloch, KD AF Buys, Emmanuel S. Raher, Michael J. Kirby, Andrew Hayton, Sarah R. Baron, David M. Sips, Patrick Y. Mohd, Shahid Rauwerdink, Kristen M. Yan, Qingshang Tainsh, Laurel T. Shakartzi, Hannah Stevens, Christine Decaluwe, Kelly Van de Voorde, Johan Wang, Tong Brouckaert, Peter Daly, Mark J. Bloch, Kenneth D. TI Genetic Mapping of a Modifier Locus Affecting Blood Pressure in Soluble Guanylate Cyclase alpha 1-Deficient Mice SO CIRCULATION LA English DT Meeting Abstract DE Hypertension; Nitric oxide; Genome-wide association studies (GWAS); Aldosterone; Vascular C1 [Buys, Emmanuel S.; Raher, Michael J.; Hayton, Sarah R.; Baron, David M.; Sips, Patrick Y.; Mohd, Shahid; Rauwerdink, Kristen M.; Tainsh, Laurel T.; Shakartzi, Hannah; Bloch, Kenneth D.] Massachusetts Gen Hosp, Anesthesia Cntr Crit Care Rsch, Boston, MA 02114 USA. [Kirby, Andrew; Stevens, Christine] Massachusetts Gen Hosp, Cntr Human Genet Rsch, Boston, MA 02114 USA. [Yan, Qingshang; Wang, Tong] Yale Univ, Sch Med, New Haven, CT USA. [Brouckaert, Peter] Univ Ghent, VIB, B-9000 Ghent, Belgium. NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13076 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705032 ER PT J AU Byrd, JB Maddox, TM O'Donnell, C Bhatt, DL Tsai, TT Rumsfeld, JS Ho, PM AF Byrd, James B. Maddox, Thomas M. O'Donnell, Colin Bhatt, Deepak L. Tsai, Thomas T. Rumsfeld, John S. Ho, P. M. TI Hospital-Level Variation in Delays to Clopidogrel Filling Following Stent Implantation and Short-Term Cardiovascular Outcomes: Insights from the National VA Clinical Assessment, Reporting, and Tracking (CART) Program SO CIRCULATION LA English DT Meeting Abstract DE Clopidogrel; Adherence; Quality assessment; Health services research; Outcomes C1 [Maddox, Thomas M.; Tsai, Thomas T.; Rumsfeld, John S.; Ho, P. M.] Univ Colorado Denver, VA Eastern Colorado Hlth Care Syst, Aurora, CO USA. [Bhatt, Deepak L.] Brigham & Womens Hosp, VA Boston Healthcare Syst, Brockton, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13974 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705363 ER PT J AU Chatterjee, NA Murphy, RM Malhotra, R Hough, SS Pappagianopoulos, PP Semigran, MJ Lewis, GD AF Chatterjee, Neal A. Murphy, Ryan M. Malhotra, Rajeev Hough, Stacyann S. Pappagianopoulos, Paul P. Semigran, Marc J. Lewis, Gregory D. TI Oxygen Uptake Kinetics Are Closely Related to Right Ventricular-Pulmonary Vascular Function During Exercise in Heart Failure SO CIRCULATION LA English DT Meeting Abstract DE Exercise tests; Oxygen uptake C1 [Chatterjee, Neal A.; Murphy, Ryan M.; Malhotra, Rajeev; Hough, Stacyann S.; Pappagianopoulos, Paul P.; Semigran, Marc J.; Lewis, Gregory D.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 3 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16579 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708087 ER PT J AU Chuang, ML Gona, P Oyama-Manabe, N Manders, ES Salton, CJ Hoffmann, U Manning, WJ O'Donnell, CJ AF Chuang, Michael L. Gona, Philimon Oyama-Manabe, Noriko Manders, Emily S. Salton, Carol J. Hoffmann, Udo Manning, Warren J. O'Donnell, Christopher J. TI Prevalence and Risk Factor Correlates of Descending Aortic Plaque in the Framingham Offspring Cohort: Comparison of Noncontrast Magnetic Resonance and Noncontrast Computed Tomography SO CIRCULATION LA English DT Meeting Abstract DE Arteriosclerosis; Aorta; Computed tomography; Magnetic resonance imaging; Risk factors C1 [Chuang, Michael L.; Gona, Philimon; Manders, Emily S.; O'Donnell, Christopher J.] NHLBIs Framingham Heart Study, Framingham, MA USA. [Oyama-Manabe, Noriko; Salton, Carol J.; Manning, Warren J.] Beth Israel Deaconess Med Ctr, Div Cardiovasc, Boston, MA 02215 USA. [Hoffmann, Udo] Massachusetts Gen Hosp, Boston, MA 02114 USA. RI Oyama-Manabe, Noriko/A-5212-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A10775 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738703042 ER PT J AU Clerte, M Baron, DM Flynn, A Raher, MJ Bloch, KD Picard, MH Buys, ES Brouckaert, P Scherrer-Crosbie, M AF Clerte, Maeva Baron, David M. Flynn, Aidan Raher, Michael J. Bloch, Kenneth D. Picard, Michael H. Buys, Emmanuel S. Brouckaert, Peter Scherrer-Crosbie, Marielle TI Detection of Brown Adipose Tissue Activation and Mass Using Contrast Ultrasound SO CIRCULATION LA English DT Meeting Abstract DE Contrast echo; Adipose C1 [Clerte, Maeva; Flynn, Aidan; Picard, Michael H.; Scherrer-Crosbie, Marielle] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Brouckaert, Peter] Univ Ghent, B-9000 Ghent, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16795 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708156 ER PT J AU Derwall, M Malhotra, R Beppu, Y Zapol, WM Yu, PB Bloch, KD AF Derwall, Matthias Malhotra, Rajeev Beppu, Yuko Zapol, Warren M. Yu, Paul B. Bloch, Kenneth D. TI Bone Morphogenetic Protein Signaling is a Regulator of Hepatic Cholesterol Biosynthesis in vitro and in vivo SO CIRCULATION LA English DT Meeting Abstract DE Lipids; Lipoproteins; Cholesterol-lowering drugs; Arteriosclerosis; Statins C1 [Malhotra, Rajeev] Massachusetts Gen Hosp, Cardiovasc Rsch Cntr, Boston, MA 02114 USA. [Malhotra, Rajeev; Yu, Paul B.] Massachusetts Gen Hosp, Div Cardiol, Dept Med, Boston, MA 02114 USA. [Derwall, Matthias; Malhotra, Rajeev; Beppu, Yuko; Zapol, Warren M.; Yu, Paul B.; Bloch, Kenneth D.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13617 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705227 ER PT J AU Desai, NR Morrow, DA Murphy, SA Gerszten, RE Cannon, CP Sabatine, MS AF Desai, Nihar R. Morrow, David A. Murphy, Sabina A. Gerszten, Robert E. Cannon, Christopher P. Sabatine, Marc S. TI Evaluation of Multiple Biomarkers of Cardiomyocyte Stress or Injury to Predict Cardiovascular Death or CHF in STEMI: Findings from CLARITY-TIMI 28 SO CIRCULATION LA English DT Meeting Abstract DE STEMI; Biomarkers; Natriuretic peptides, atrial C1 [Desai, Nihar R.; Morrow, David A.; Murphy, Sabina A.; Cannon, Christopher P.; Sabatine, Marc S.] Brigham & Womens Hosp, TIMI Study Grp, Boston, MA 02115 USA. [Gerszten, Robert E.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16198 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707329 ER PT J AU Dubin, R Li, YM Ix, JH Shlipak, M Whooley, M Peralta, CA AF Dubin, Ruth Li, Yongmei Ix, Joachim H. Shlipak, Michael Whooley, Mary Peralta, Carmen A. TI Associations of Pentraxin-3 With Cardiovascular Events, Incident Heart Failure and Mortality Among Persons With Coronary Heart Disease: Data From the Heart and Soul Study SO CIRCULATION LA English DT Meeting Abstract DE Biomarkers; Heart failure; Renal function; Epidemiology C1 [Dubin, Ruth; Peralta, Carmen A.] UC San Francisco, San Francisco, CA USA. [Li, Yongmei; Shlipak, Michael; Whooley, Mary] San Francisco VA Med Ctr, San Francisco, CA USA. [Ix, Joachim H.] UC San Diego, La Jolla, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15991 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707258 ER PT J AU Dubin, R Schiller, NB Teerlink, JR Alokozai, D Johansen, K AF Dubin, Ruth Schiller, Nelson B. Teerlink, John R. Alokozai, Dean Johansen, Kirsten TI Dialysis-Related Symptoms are Associated with Deterioration of Cardiac Function During Dialysis SO CIRCULATION LA English DT Meeting Abstract DE Kidney; Diastolic function; Ejection fraction C1 [Dubin, Ruth; Schiller, Nelson B.; Johansen, Kirsten] UC San Francisco, San Francisco, CA USA. [Teerlink, John R.] San Francisco VA Med Ctr, San Francisco, CA USA. [Alokozai, Dean] Cardiocore, Echocardiog, San Francisco, CA USA. RI Teerlink, John/D-2986-2012 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A11164 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738703153 ER PT J AU Felker, GM Tang, WHW Hernandez, AF Hasselblad, V Armstrong, PW Fonarow, GC Voors, AA Metra, M Butler, J Dickstein, K Troughton, RW Anker, SD Heizer, GM Massie, BM McMurray, JJ Califf, RM Starling, RC O'Connor, CM AF Felker, G. Michael Tang, W. H. Wilson Hernandez, Adrian F. Hasselblad, Vic Armstrong, Paul W. Fonarow, Gregg C. Voors, Adriaan A. Metra, Marco Butler, Javed Dickstein, Kenneth Troughton, Richard W. Anker, Stefan D. Heizer, Gretchen M. Massie, Barry M. McMurray, John J. Califf, Robert M. Starling, Randall C. O'Connor, Christopher M. TI High Sensitivity Troponin I in Acute Decompensated Heart Failure: Insights from the ASCEND-HF Study SO CIRCULATION LA English DT Meeting Abstract CT Scientific Sessions of the American-Heart-Association/Resuscitation Science Symposium CY NOV 12-16, 2011 CL Orlando, FL SP Amer Heart Assoc DE Biomarkers C1 [Felker, G. Michael; Hernandez, Adrian F.; Hasselblad, Vic; Heizer, Gretchen M.; O'Connor, Christopher M.] Duke Univ, Med Ctr, Duke Clin Rsch Inst, Durham, NC USA. [Tang, W. H. Wilson; Starling, Randall C.] Cleveland Clin, Cleveland, OH 44106 USA. [Armstrong, Paul W.] Univ Alberta, Edmonton, AB, Canada. [Fonarow, Gregg C.] Univ Calif Los Angeles, Los Angeles, CA USA. [Voors, Adriaan A.] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands. [Metra, Marco] Univ Brescia, Brescia, Italy. [Butler, Javed] Emory Univ, Atlanta, GA 30322 USA. [Dickstein, Kenneth] Univ Bergen, Inst Internal Med, Stavanger Univ Hosp, Bergen, Norway. [Troughton, Richard W.] Univ Otago, Christchurch, New Zealand. [Anker, Stefan D.] Appl Cachexia Rsch, Dept Cardiol, Berlin, Germany. [Massie, Barry M.] Univ Calif San Francisco, San Francisco VA Med Ctr, San Francisco, CA 94143 USA. [McMurray, John J.] Univ Glasgow, Glasgow, Lanark, Scotland. [Califf, Robert M.] Duke Univ, Med Ctr, Duke Translat Med Inst, Durham, NC USA. RI Tang, Wai Hong/I-1238-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13262 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705098 ER PT J AU Figueroa, AL Abdelbaky, A Corsini, EM Lawler, MA Gurm, G Uthamalingam, S Subramanian, S Vijayakumar, J Brady, TJ Hoffmann, U Tawakol, A AF Figueroa, Amparo L. Abdelbaky, Amr Corsini, Erin M. Lawler, Meredith A. Gurm, Gagandeep Uthamalingam, Shanmugam Subramanian, Sharath Vijayakumar, Jayanthi Brady, Thomas J. Hoffmann, Udo Tawakol, Ahmed TI Measurement of Atherosclerotic Inflammation with FDG-PET Imaging Improves Cardiovascular Risk Stratification SO CIRCULATION LA English DT Meeting Abstract DE Positron emission tomography; Risk factors; Cardiovascular disease; Myocardial infarction; Stroke C1 [Figueroa, Amparo L.; Abdelbaky, Amr; Corsini, Erin M.; Lawler, Meredith A.; Gurm, Gagandeep; Uthamalingam, Shanmugam; Subramanian, Sharath; Vijayakumar, Jayanthi; Brady, Thomas J.; Hoffmann, Udo; Tawakol, Ahmed] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16875 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708194 ER PT J AU Fontes, JDT Yamamoto, JY Larson, MG Wang, N Dallmeier, D Rienstra, M Hakanson, AS Schnabel, RB Vasan, RS Keaney, JF Benjamin, EJ AF Fontes, Joao Daniel T. Yamamoto, Jennifer Y. Larson, Martin G. Wang, Na Dallmeier, Dhayana Rienstra, Michiel Hakanson, Amanda S. Schnabel, Renate B. Vasan, Ramachandran S. Keaney, John F., Jr. Benjamin, Emelia J. TI Increase in Concentration of Inflammatory Biomarker is Partially Explained by Traditional Cardiovascular Risk Factors SO CIRCULATION LA English DT Meeting Abstract DE Biomarkers; Longitudinal studies; Risk factors; Epidemiology; Inflammation C1 [Fontes, Joao Daniel T.; Larson, Martin G.; Vasan, Ramachandran S.; Benjamin, Emelia J.] Boston Univ, Framingham, MA USA. [Yamamoto, Jennifer Y.; Wang, Na; Dallmeier, Dhayana; Hakanson, Amanda S.] Boston Univ, Boston, MA 02215 USA. [Rienstra, Michiel] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Schnabel, Renate B.] Johannes Gutenberg Univ Mainz, Mainz, Germany. [Keaney, John F., Jr.] Univ Massachusetts, Worcester, MA 01605 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13856 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705323 ER PT J AU Fontes, JDT Cheng, S McCabe, EL Hwang, SJ Vasan, RS Shaw, SY Cohen, KS Larson, MG Benjamin, EJ Wang, TJ AF Fontes, Joao Daniel T. Cheng, Susan McCabe, Elizabeth L. Hwang, Shih-Jen Vasan, Ramachandran S. Shaw, Stanley Y. Cohen, Kenneth S. Larson, Martin G. Benjamin, Emelia J. Wang, Thomas J. TI Circulating Endothelial Progenitor Cell Phenotypes are Weakly Associated With Select Biomarkers of Inflammation SO CIRCULATION LA English DT Meeting Abstract DE Biomarkers; Angiogenesis; Cardiovascular disease; Epidemiology; Risk factors C1 [Fontes, Joao Daniel T.; Vasan, Ramachandran S.; Larson, Martin G.; Benjamin, Emelia J.] Boston Univ, Framingham, MA USA. [Cheng, Susan; McCabe, Elizabeth L.; Hwang, Shih-Jen; Cohen, Kenneth S.; Wang, Thomas J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Shaw, Stanley Y.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13763 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705285 ER PT J AU Friedman, DJ Altman, RK Park, MY Orencole, M Britt, CM Picard, MH Ruskin, JN Singh, JP Heist, EK AF Friedman, Daniel J. Altman, Robert K. Park, Mi Young Orencole, Mary Britt, Carmella M. Picard, Michael H. Ruskin, Jeremy N. Singh, Jagmeet P. Heist, Edwin K. TI Progressive Worsening of Left Ventricular Size and Function is Associated with Increased Ventricular Arrhythmia Burden Among Patients Undergoing Cardiac Resynchronization Therapy SO CIRCULATION LA English DT Meeting Abstract DE Ventricular arrhythmia; CRT; Heart failure; Prognosis C1 [Altman, Robert K.; Orencole, Mary; Britt, Carmella M.; Ruskin, Jeremy N.; Singh, Jagmeet P.; Heist, Edwin K.] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA. [Park, Mi Young; Picard, Michael H.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9885 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738702152 ER PT J AU Giraldez, RR Clare, R Lopes, RD Dalby, AJ Prabhakaran, D Brogan, GX Giugliano, RP Tricoci, P James, SK Tanguay, JF Pollack, CV Harrington, RA Braunwald, E Newby, LK AF Giraldez, Roberto R. Clare, Robert Lopes, Renato D. Dalby, Anthony J. Prabhakaran, Dorairaj Brogan, Gerald X., Jr. Giugliano, Robert P. Tricoci, Pierluigi James, Stefan K. Tanguay, Jean-Francois Pollack, Charles V., Jr. Harrington, Robert A. Braunwald, Eugene Newby, L. K. TI Undiagnosed Diabetes Mellitus, Pre-Diabetes, and Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndromes SO CIRCULATION LA English DT Meeting Abstract DE Acute coronary syndromes; Risk factors; Outcomes C1 [Giraldez, Roberto R.] Univ Sao Paulo, Inst Coracao, Sao Paulo, Brazil. [Clare, Robert; Lopes, Renato D.; Tricoci, Pierluigi; Harrington, Robert A.; Newby, L. K.] Duke Univ Med Cntr, Duke Clin Rsch Inst, Durham, NC USA. [Dalby, Anthony J.] Milpk Hosp, Johannesburg, South Africa. [Prabhakaran, Dorairaj] Cntr Chron Dis Control, New Delhi, India. [Brogan, Gerald X., Jr.] NYU Sch Med, Dept Clin Emergency Med, New York, NY USA. [Giugliano, Robert P.; Braunwald, Eugene] Brigham & Womens Hosp, TIMI Study Grp, Boston, MA 02115 USA. [James, Stefan K.] Univ Uppsala Hosp, Uppsala, Sweden. [Tanguay, Jean-Francois] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada. [Pollack, Charles V., Jr.] Penn Hosp, Dept Emergency Med, Philadelphia, PA 19107 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9147 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701275 ER PT J AU Gold, MR Birgersdotter-Green, U Singh, JP Ellenbogen, KA Yu, YH Meyer, TE Seth, M Tchou, PJ AF Gold, Michael R. Birgersdotter-Green, Ulrika Singh, Jagmeet P. Ellenbogen, Kenneth A. Yu, Yinghong Meyer, Timothy E. Seth, Milan Tchou, Patrick J. TI The Role of Electrical Delay (QLV) to Predict Left Ventricular Reverse Remodeling with Cardiac Resynchronization Therapy SO CIRCULATION LA English DT Meeting Abstract DE Heart failure; Resynchronization therapy; Outcomes C1 [Gold, Michael R.] MUSC, Div Cardiol, Charleston, SC USA. [Birgersdotter-Green, Ulrika] Univ Calif San Diego, Dept Cardiol, San Diego, CA 92103 USA. [Singh, Jagmeet P.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA. [Ellenbogen, Kenneth A.] Virginia Commonwealth Univ, Med Cntr, Div Cardiol, Richmond, VA USA. [Yu, Yinghong] Boston Sci Corp, CRV Rsch, St Paul, MN USA. [Meyer, Timothy E.; Seth, Milan] Boston Sci Corp, CRV Clin Programs, St Paul, MN USA. [Tchou, Patrick J.] Cleveland Clin, Div Cardiol, Cleveland, OH 44106 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12258 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704160 ER PT J AU Gornik, HL Hutchisson, M Khan, M Benenati, JF Jaff, MR Katanick, S Needleman, L AF Gornik, Heather L. Hutchisson, Marge Khan, Mariam Benenati, James F. Jaff, Michael R. Katanick, Sandra Needleman, Laurence TI Diagnostic Criteria for Ultrasound Diagnosis of Internal Carotid Artery Stenosis Vary Widely Among Accredited Vascular Laboratories. A Survey from the Intersocietal Commission for the Accreditation of Vascular Laboratories (ICAVL) SO CIRCULATION LA English DT Meeting Abstract DE Carotid arteries; Ultrasound; Vascular disease C1 [Gornik, Heather L.; Khan, Mariam] Cleveland Clin Fdn, Cleveland, OH 44195 USA. [Hutchisson, Marge] ICAVL, Intersocietal Commiss Accreditat Vasc Labs, Ellicott City, MD USA. [Benenati, James F.] Baptist Cardiac & Vasc Inst, Peripheral Vasc Lab, Miami, FL USA. [Jaff, Michael R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Katanick, Sandra] Intersocietal Accreditat Commiss, Intersocietal Commiss Accreditat Vasc Labs, Ellicott City, MD USA. [Needleman, Laurence] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A8918 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701231 ER PT J AU Harris, KM Braverman, AC Pyeritz, R Myrmel, T Peterson, M Voehringer, M Fattori, R Januzzi, JL Gilon, D Montgomery, D Eagle, KA Nienaber, CA Isselbacher, EM Evangelista, A AF Harris, Kevin M. Braverman, Alan C. Pyeritz, Reed Myrmel, Truls Peterson, Mark Voehringer, Matthias Fattori, Rossella Januzzi, James L. Gilon, Dan Montgomery, Daniel Eagle, Kim A. Nienaber, Christoph A. Isselbacher, Eric M. Evangelista, Arturo TI Acute Aortic Intramural Hematoma: an Analysis from the International Registry of Acute Aortic Dissection SO CIRCULATION LA English DT Meeting Abstract DE Aortic diseases; Outcomes; Vascular disease C1 [Harris, Kevin M.] Minneapolis Heart Inst Fdn, Minneapolis, MN USA. [Braverman, Alan C.] Washington Univ, Marfan Syndrome Clin, St Louis, MO USA. [Pyeritz, Reed] Univ Penn, Dept Cardiol, Philadelphia, PA 19104 USA. [Myrmel, Truls] Univ Tromso Hosp, Dept Cardiol, N-9012 Tromso, Norway. [Peterson, Mark] St Med Hosp, Dept Cardiol, Toronto, ON, Canada. [Voehringer, Matthias] Univ Minnesota, Minneapolis Heart Inst, Auerbachstrasse, Germany. [Fattori, Rossella] Univ Hosp S Orsola, Dept Cardiol, Policlinico, Italy. [Januzzi, James L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Gilon, Dan] Hadassah Univ Hosp, Inst Heart, IL-91120 Jerusalem, Israel. [Montgomery, Daniel; Eagle, Kim A.] Univ Michigan, Ann Arbor, MI 48109 USA. [Nienaber, Christoph A.] Univ Hosp Eppendorf Rostock, Rostock, Germany. [Isselbacher, Eric M.] Massachusetts Gen Hosp, Thorac Aort Cntr, Boston, MA 02114 USA. [Evangelista, Arturo] Hosp Gen Univ Vall DHebron, Barcelona, Spain. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A17170 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708287 ER PT J AU Heist, EK Herre, JM Binkley, PF Van Bakel, AB Porterfield, JG Porterfield, LM Pavri, BB AF Heist, E. Kevin Herre, John M. Binkley, Philip F. Van Bakel, Adrian B. Porterfield, James G. Porterfield, Linda M. Pavri, Behzad B. TI Analysis of a Different Device-Based Intrathoracic Impedance Vector for Detection of Heart Failure Events: Results of the DEFEAT-PE Study SO CIRCULATION LA English DT Meeting Abstract DE Pulmonary edema; Implantable cardioconvert defibrillator; Pacemakers; Heart failure C1 [Heist, E. Kevin] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA. [Herre, John M.] Sentara Norfolk Gen Hosp, Norfolk, VA USA. [Binkley, Philip F.] Ohio State Univ, Columbus, OH 43210 USA. [Van Bakel, Adrian B.] Med Univ S Carolina, Charleston, SC 29425 USA. [Porterfield, James G.; Porterfield, Linda M.] Methodist Univ Hosp, Memphis, TN USA. [Pavri, Behzad B.] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13586 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705217 ER PT J AU Hou, JB Huang, XT Wang, XL Wang, XD Fang, Y Zhang, SS Yu, B Jang, IK AF Hou, Jingbo Huang, Xingtao Wang, Xinlong Wang, Xuedong Fang, Yan Zhang, Shaosong Yu, Bo Jang, Ik-Kyung TI Changes in Neointimal Tissue Characteristics Inside Sirolimus-Eluting Stent Over Time: OCT Quantitative Tissue Property Analysis SO CIRCULATION LA English DT Meeting Abstract DE Cardiovascular imaging; Coronary artery disease; Vasculogenesis C1 [Hou, Jingbo; Huang, Xingtao; Wang, Xinlong; Wang, Xuedong; Fang, Yan; Yu, Bo] Harbin Med Coll, Affiliated Hosp 2, Harbin, Peoples R China. [Zhang, Shaosong] St Jude Med, LightLab Imaging, Westford, MA USA. [Jang, Ik-Kyung] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12534 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704237 ER PT J AU Hsich, E Grau-Sepulveda, MV Hernandez, A Peterson, ED Schwamm, LH Bhatt, DL Fonarow, G AF Hsich, Eileen Grau-Sepulveda, Maria V. Hernandez, Adrian Peterson, Eric D. Schwamm, Lee H. Bhatt, Deepak L. Fonarow, Gregg TI Sex Differences for Heart Failure Patients with Preserved and Reduced Systolic Function: Data from the American Heart Association Get With the Guidelines-Heart Failure SO CIRCULATION LA English DT Meeting Abstract CT Scientific Sessions of the American-Heart-Association/Resuscitation Science Symposium CY NOV 12-16, 2011 CL Orlando, FL SP Amer Heart Assoc DE Heart failure C1 [Hsich, Eileen] Cleveland Clin, Cleveland, OH 44106 USA. [Schwamm, Lee H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Bhatt, Deepak L.] VA Boston Healthcare Syst, Cardiol, W Roxbury, MA USA. [Fonarow, Gregg] Univ Calif Los Angeles, Los Angeles, CA USA. [Grau-Sepulveda, Maria V.; Hernandez, Adrian; Peterson, Eric D.] Duke, Duke Clin Rsch, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12863 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704341 ER PT J AU Hynes, B Ruggiero, NJ Kennedy, KF Rosenfield, K Garasic, JM AF Hynes, Brian Ruggiero, Nicholas J. Kennedy, Kevin F. Rosenfield, Kenneth Garasic, Joseph M. TI Outcomes of Carotid Artery Stenting for Recurrent Carotid Artery Restenosis Following Prior Ipsilateral Carotid Artery Endarterectomy or Stenting SO CIRCULATION LA English DT Meeting Abstract C1 [Hynes, Brian; Ruggiero, Nicholas J.; Rosenfield, Kenneth; Garasic, Joseph M.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Kennedy, Kevin F.] Univ Missouri, Kansas City, MO 64110 USA. [Kennedy, Kevin F.] St Lukes Mid Amer Heart Inst, Div Cardiol, Kansas City, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A14423 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738706117 ER PT J AU Jones, M Chokshi, A Collado, JE Layton, A Armstrong, HF Forman, DE Bartels, M Mancini, D Schulze, PC AF Jones, Meaghan Chokshi, Aalap Collado, J. Elias Layton, Aimee Armstrong, Hilary F. Forman, Daniel E. Bartels, Matthew Mancini, Donna Schulze, P. Christian TI Prolonged Muscle Fiber Recruitment Intervals and Impaired Skeletal Muscle Work Capacity in Patients With Advanced Heart Failure SO CIRCULATION LA English DT Meeting Abstract DE Heart failure; Exercise tests; Muscle, skeletal C1 [Jones, Meaghan; Chokshi, Aalap; Collado, J. Elias; Layton, Aimee; Armstrong, Hilary F.; Bartels, Matthew; Mancini, Donna; Schulze, P. Christian] Columbia Univ Med Cntr, New York, NY USA. [Forman, Daniel E.] VA Boston Healthcare Syst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13748 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705278 ER PT J AU Jonker, FH Trimarchi, S Moll, FL Rampoldi, V Patel, H O'Gara, P Peterson, MD Fattori, R Voehringer, M Pyeritz, RE Hutchison, S Montgomery, D Isselbacher, EM Nienaber, CA Eagle, KA AF Jonker, Frederik H. Trimarchi, Santi Moll, Frans L. Rampoldi, Vincenzo Patel, Himanshu O'Gara, Patrick Peterson, Mark D. Fattori, Rossella Voehringer, Matthias Pyeritz, Reed E. Hutchison, Stuart Montgomery, Daniel Isselbacher, Eric M. Nienaber, Christoph A. Eagle, Kim A. TI Predictors of Aortic Growth After Acute Type B Aortic Dissection SO CIRCULATION LA English DT Meeting Abstract C1 [Jonker, Frederik H.] Maastad Hosp Rotterdam, Dept Surg, Rotterdam, Netherlands. [Trimarchi, Santi] IRCCS Policlin San Donato, Ctr Cardiovasc, San Donato Milanese, Italy. [Moll, Frans L.; Rampoldi, Vincenzo] IRCCS Policlin, Ctr Cardiovasc, San Donato Milanese, Italy. [Patel, Himanshu] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA. [O'Gara, Patrick] Brigham&Womans Hosp, Boston, MA USA. [Peterson, Mark D.] St Michaels Hosp, Div Cardiac Surg, Toronto, ON M5B 1W8, Canada. [Fattori, Rossella] Univ Hosp S Orsola, Bologna, Italy. [Voehringer, Matthias] Robert Bosch Krankenhaus, Stuttgart, Germany. [Pyeritz, Reed E.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Hutchison, Stuart] Univ Calgary, Dept Cardiol, Med Ctr, Calgary, AB, Canada. [Isselbacher, Eric M.] Massachusetts Gen Hosp, Thorac Aort Ctr, Boston, MA 02114 USA. [Nienaber, Christoph A.] Univ Hosp Eppendorf Rostock, Dept Internal Med, Rostock, Germany. RI Trimarchi, Santi/J-7361-2016 OI Trimarchi, Santi/0000-0001-5996-3264 NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15306 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707021 ER PT J AU Kaess, BM Pedley, A Massaro, JM Larson, MG Corsini, E Hoffmann, U Smith, HM Sawyer, DB Vasan, RS Fox, CS AF Kaess, Bernhard M. Pedley, Alison Massaro, Joseph M. Larson, Martin G. Corsini, Erin Hoffmann, Udo Smith, Holly M. Sawyer, Douglas B. Vasan, Ramachandran S. Fox, Caroline S. TI Relation of Vascular Growth Factors with CT-Derived Measures of Body Fat Distribution: The Framingham Heart Study SO CIRCULATION LA English DT Meeting Abstract CT Scientific Sessions of the American-Heart-Association/Resuscitation Science Symposium CY NOV 12-16, 2011 CL Orlando, FL SP Amer Heart Assoc DE Adipose; Vasculogenesis; Obesity C1 [Kaess, Bernhard M.; Pedley, Alison; Larson, Martin G.; Vasan, Ramachandran S.; Fox, Caroline S.] Framingham Heart Dis Epidemiol Study, Sch Publ Hlth, Dept Biostat, Framingham, MA 02114 USA. [Massaro, Joseph M.] Boston Univ, Dept Radiol, Boston, MA USA. [Corsini, Erin; Hoffmann, Udo] Massachusetts Gen Hosp, Cardiovasc Div, Boston, MA USA. [Smith, Holly M.; Sawyer, Douglas B.] Vanderbilt Univ, Nashville, TN USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9803 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738702128 ER PT J AU Kallianos, KG Engel, LC Szymonifka, J Maurovich-Horvat, P Schlett, CL Fox, CS Nagurney, JT Hoffmann, U Truong, QA AF Kallianos, Kimberly G. Engel, Leif-Christopher Szymonifka, Jackie Maurovich-Horvat, Pal Schlett, Christopher L. Fox, Caroline S. Nagurney, John T. Hoffmann, Udo Truong, Quynh A. TI Pericoronary Fat is Independently Associated to the Presence and Extent of Coronary Artery Disease as Compared to Other Thoracic Fat Depots SO CIRCULATION LA English DT Meeting Abstract DE Cardiac CT; Adipose; Coronary artery disease C1 [Kallianos, Kimberly G.; Engel, Leif-Christopher; Maurovich-Horvat, Pal; Schlett, Christopher L.; Hoffmann, Udo; Truong, Quynh A.] Massachusetts Gen Hosp, Cardiac MR PET CT Program, Boston, MA 02114 USA. [Fox, Caroline S.] NHLBI, Framingham Heart Study, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13661 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705246 ER PT J AU Kawase, Y Honye, J Okubo, M Miyake, T Kamikawa, S Ota, H Kondo, H Tsuchiya, K Matsuo, H Jang, IK Ueno, K AF Kawase, Yoshiaki Honye, Junko Okubo, Munenori Miyake, Taiji Kamikawa, Sigeshi Ota, Hideaki Kondo, Hiroki Tsuchiya, Kunihiko Matsuo, Hitoshi Jang, Ik-Kyung Ueno, Katsumi TI The Early Calcification in Neointima of in Stent Restenosis SO CIRCULATION LA English DT Meeting Abstract DE Calcification; Restenosis; Intravascular ultrasound/Doppler; Stent C1 [Kawase, Yoshiaki; Honye, Junko; Okubo, Munenori; Miyake, Taiji; Kamikawa, Sigeshi; Ota, Hideaki; Kondo, Hiroki; Tsuchiya, Kunihiko; Matsuo, Hitoshi; Ueno, Katsumi] Gifu Heart Cntr, Gifu, Japan. [Jang, Ik-Kyung] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A8611 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701146 ER PT J AU Kim, HN Truong, QA Rehman, SU Mohammed, AA Bhardwaj, A Parks, K Sullivan, D Chen-Tournoux, A Moore, SA Barajas, J Barajas, L Weiner, RB Baggish, AL Semigran, MJ Januzzi, JL AF Kim, Han-Na Truong, Quynh A. Rehman, Shafiq U. Mohammed, Asim A. Bhardwaj, Anju Parks, Kimberly Sullivan, Dorothy Chen-Tournoux, Annabel Moore, Stephanie A. Barajas, Justine Barajas, Linda Weiner, Rory B. Baggish, Aaron L. Semigran, Marc J. Januzzi, James L. TI Predicting Non-response to NT-proBNP Guided Heart Failure Management Using the PROTECT Risk Score SO CIRCULATION LA English DT Meeting Abstract DE Heart failure; Biomarkers; Natriuretic peptide; Risk factors C1 [Kim, Han-Na; Rehman, Shafiq U.; Mohammed, Asim A.; Bhardwaj, Anju; Parks, Kimberly; Sullivan, Dorothy; Chen-Tournoux, Annabel; Moore, Stephanie A.; Barajas, Justine; Barajas, Linda; Weiner, Rory B.; Baggish, Aaron L.; Semigran, Marc J.; Januzzi, James L.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Truong, Quynh A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13081 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705035 ER PT J AU Kim, JW Thompson, B Kessinger, CW Henke, PK McCarthy, JR Lin, CP Jaffer, FA AF Kim, Jin Won Thompson, Brian Kessinger, Chase W. Henke, Peter K. McCarthy, Jason R. Lin, Charles P. Jaffer, Farouc A. TI Short-Term Statin Therapy Improves Murine Deep Venous Thrombosis Resolution While Reducing Thrombus Inflammation: An in vivo Multi-Targeted Imaging Study SO CIRCULATION LA English DT Meeting Abstract DE Inflammation; Venous thrombosis; Imaging agents; Molecular C1 [Kim, Jin Won; Kessinger, Chase W.; Jaffer, Farouc A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cardiovasc Rsch Ctr, Boston, MA USA. [Kim, Jin Won] Korea Univ, Seoul, South Korea. [Thompson, Brian] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr,Wellman Ctr Photomed, Boston, MA USA. [Henke, Peter K.] Univ Michigan, Vasc Surg Sect, Ann Arbor, MI 48109 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9505 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738702042 ER PT J AU Kinlay, S Gaziano, M Young, M Lawler, E Faxon, DP AF Kinlay, Scott Gaziano, Michael Young, Melissa Lawler, Elizabeth Faxon, David P. TI Prolonged Use of Clopidogrel and Risk of Death and Myocardial Infarction 4 Years after Coronary Stenting in Diabetes: the VA DES Study SO CIRCULATION LA English DT Meeting Abstract DE Stent Cardiovascular therapeutics Coronary heart disease C1 [Kinlay, Scott; Faxon, David P.] VA Boston Healthcare Syst, Div Cardiovasc, W Roxbury, MA USA. [Gaziano, Michael; Young, Melissa; Lawler, Elizabeth] VA Boston Healthcare Syst, MAVERIC, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A18334 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738709146 ER PT J AU Kociol, RD McNulty, SE Lee, KL Apple, FS Tracy, RP Hernandez, AF Mentz, RJ Braunwald, E O'Connor, CM Felker, GM AF Kociol, Robb D. McNulty, Steven E. Lee, Kerry L. Apple, Fred S. Tracy, Russell P. Hernandez, Adrian F. Mentz, Robert J. Braunwald, Eugene O'Connor, Christopher M. Felker, G. Michael TI Circulating Cardiac Troponin I as Detected By a High-Sensitivity Assay among Patients Hospitalized with Acute Decompensated Heart Failure SO CIRCULATION LA English DT Meeting Abstract DE Hemodynamics; Acute heart failure; Outcomes C1 [Kociol, Robb D.; Lee, Kerry L.; Mentz, Robert J.; O'Connor, Christopher M.; Felker, G. Michael] Duke Univ, Durham, NC USA. [McNulty, Steven E.; Hernandez, Adrian F.] Duke Clin Rsch Inst, Durham, NC USA. [Apple, Fred S.] Hennepin Cty Med Cntr, Minneapolis, MN USA. [Apple, Fred S.] Univ Minnesota, Minneapolis, MN USA. [Tracy, Russell P.] Univ Vermont, Burlington, VT USA. [Braunwald, Eugene] Brigham & Womens Hosp, TIMI Study Grp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16818 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708170 ER PT J AU Kostis, WJ Deng, YZ Moreyra, AE Pantazopoulos, JS Kostis, JB AF Kostis, William J. Deng, Yingzi Moreyra, Abel E. Pantazopoulos, John S. Kostis, John B. CA Myocardial Infarction Data TI No Decrease in the Incidence of Heart Failure Following Acute Myocardial Infarction in the Years 1994-2006 SO CIRCULATION LA English DT Meeting Abstract DE Myocardial infarction; Heart failure; Epidemiology; Outcomes C1 [Kostis, William J.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Deng, Yingzi; Moreyra, Abel E.; Pantazopoulos, John S.; Kostis, John B.] UMDNJ Robert Wood Johnson Med Sch, Cardiovasc Inst, New Brunswick, NJ USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A17546 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708400 ER PT J AU Kumbhani, DJ Steg, PG Cannon, CP Eagle, KA Smith, SC Crowley, K Goto, S Ohman, EM Bhatt, DL AF Kumbhani, Dharam J. Steg, Ph Gabriel Cannon, Christopher P. Eagle, Kim A. Smith, Sidney C., Jr. Crowley, Kevin Goto, Shinya Ohman, E. M. Bhatt, Deepak L. CA REACH Registry Investigators TI Prospective Assessment of the Relationship Between Use of Evidence-Based Secondary Prevention Therapies and Long-Term (4-Year) Clinical Outcomes in Stable Outpatients With Established Atherothrombotic Disease: Insights from the International REduction of Atherothrombosis for Continued Health (REACH) Registry SO CIRCULATION LA English DT Meeting Abstract DE Evidence-based medicine; Risk factors; Arteriosclerosis; Community-based care; Longitudinal studies C1 [Kumbhani, Dharam J.; Cannon, Christopher P.; Crowley, Kevin] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA. [Steg, Ph Gabriel] Univ Paris Diderot, Div Cardiovasc Med, INSERM, U698, Paris, France. [Eagle, Kim A.] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA. [Steg, Ph Gabriel] Assistance Publ Hop Paris, Paris, France. [Smith, Sidney C., Jr.] Univ N Carolina, Div Cardiovasc Med, Chapel Hill, NC USA. [Goto, Shinya] Tokai Univ, Div Cardiovasc Med, Kanagawa 2591100, Japan. [Ohman, E. M.] Duke Univ, Div Cardiovasc Med, Durham, NC USA. [Bhatt, Deepak L.] Brigham & Womens Hosp, Div Cardiovasc Med, VA Boston Healthcare Syst, W Roxbury, MA USA. [Bhatt, Deepak L.] Harvard Univ, Sch Med, W Roxbury, MA USA. NR 0 TC 2 Z9 2 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15957 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707244 ER PT J AU Kumbhani, DJ Hirsch, AT Han, CH Ren, F Goto, S Steg, PG Bhatt, DL AF Kumbhani, Dharam J. Hirsch, Alan T. Han, Carin H. Ren, Fang Goto, Shinya Steg, Ph. Gabriel Bhatt, Deepak L. CA REACH Registry Investigators TI Predictors of Incident Symptomatic Peripheral Arterial Disease in Stable Outpatients: The International REduction of Atherothrombosis for Continued Health (REACH) Registry SO CIRCULATION LA English DT Meeting Abstract DE Peripheral arterial disease; Community-based care; Epidemiology; Vascular disease; Longitudinal studies C1 [Bhatt, Deepak L.] Brigham & Womens Hosp, Div Cardiovasc Med, VA Boston Healthcare Syst, Boston, MA 02115 USA. [Hirsch, Alan T.] Univ Minnesota, Sch Med, Div Cardiovasc, Minneapolis, MN 55455 USA. [Han, Carin H.] Childrens Hosp, Div Neurosurg, Boston, MA 02115 USA. [Goto, Shinya] Tokai Univ, Sch Med, Dept Med Cardiol, Hiratsuka, Kanagawa 25912, Japan. [Steg, Ph. Gabriel] Univ Paris Diderot, INSERM, U698, Div Cardiovasc Med, Paris, France. [Steg, Ph. Gabriel] AP HP, Paris, France. [Bhatt, Deepak L.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A14117 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738706021 ER PT J AU Lam, CS Anand, IS Carson, PE Massie, BM Rector, TS Kuskowski, M McKelvie, RS Zile, MR McMurray, JJ Komajda, M Kitzman, DW AF Lam, Carolyn S. Anand, Inder S. Carson, Peter E. Massie, Barry M. Rector, Thomas S. Kuskowski, Michael McKelvie, Robert S. Zile, Michael R. McMurray, John J. Komajda, Michel Kitzman, Dalane W. TI Sex Differences in Clinical Characteristics and Outcomes in Elderly Patients with Heart Failure and Preserved Ejection Fraction: The I-PRESERVE Trial SO CIRCULATION LA English DT Meeting Abstract C1 [Lam, Carolyn S.] Natl Univ Hlth Syst, Natl Univ Heart Ctr Singapore, Singapore, Singapore. [Anand, Inder S.; Rector, Thomas S.; Kuskowski, Michael] Vet Adm Med Ctr, Minneapolis, MN 55417 USA. [Anand, Inder S.] Univ Minnesota, Minneapolis, MN USA. [Carson, Peter E.] Georgetown Univ, Washington, DC USA. [Carson, Peter E.] Washington DC Vet Affairs Med Ctr, Washington, DC USA. [Massie, Barry M.] Univ Calif San Francisco, Vet Affairs Med Ctr 111C, San Francisco, CA 94143 USA. [Massie, Barry M.] San Francisco VA Med Ctr, San Francisco, CA USA. [McKelvie, Robert S.] McMaster Univ, Hamilton, ON, Canada. [Zile, Michael R.] RHJ Dept Vet Affairs Med Ctr, Dept Med, Div Cardiol, Charleston, SC USA. [Zile, Michael R.] Med Univ S Carolina, Charleston, SC 29425 USA. [McMurray, John J.] Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Rsch Ctr, Glasgow, Lanark, Scotland. [Komajda, Michel] Univ Paris, Pitie Salpetriere Hosp, Dept Cardiol, F-75252 Paris, France. [Kitzman, Dalane W.] Wake Forest Univ, Dept Internal Med Cardiol & Geriatr, Sch Med, Winston Salem, NC 27109 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A10912 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738703086 ER PT J AU Lee, S Chutkow, WA Patwari, P Feener, EP Lee, RT AF Lee, Samuel Chutkow, William A. Patwari, Parth Feener, Edward P. Lee, Richard T. TI Thioredoxin Interacting Protein Interacts with Protein Disulfide Isomerases and increases Endoplasmic Reticulum Stress SO CIRCULATION LA English DT Meeting Abstract DE Cell physiology; Redox C1 [Lee, Samuel; Chutkow, William A.; Patwari, Parth; Lee, Richard T.] Brigham & Womens Hosp, Div Cardiovasc, Dept Med, Cambridge, MA USA. [Feener, Edward P.] Joslin Diabet Cntr, Rsch Div, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15319 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707026 ER PT J AU Leonardi, S Koehler, ML Truffa, A Tricoci, P White, H Gibson, CM Stone, GW Harrington, RA Bhatt, DL Mahaffey, KW AF Leonardi, Sergio Koehler, Megan L. Truffa, Adriano Tricoci, Pierluigi White, Harvey Gibson, C. Michael Stone, Gregg W. Harrington, Robert A. Bhatt, Deepak L. Mahaffey, Kenneth W. TI A Novel Approach to Define Type 4a Myocardial Infarction in Acute Coronary Syndrome Patients Undergoing Early Invasive Management: Insights From the CHAMPION PLATFORM Trial SO CIRCULATION LA English DT Meeting Abstract DE Myocardial infarction, NSTEMI; Antiplatelet drugs; Percutaneous coronary intervention C1 [Leonardi, Sergio; Koehler, Megan L.; Truffa, Adriano; Tricoci, Pierluigi; Gibson, C. Michael; Harrington, Robert A.; Mahaffey, Kenneth W.] Duke Clin Rsch Inst, Durham, NC USA. [White, Harvey] Green Lane Cardiovasc Serv, Auckland, New Zealand. [Stone, Gregg W.] Columbia Univ, New York, NY USA. [Bhatt, Deepak L.] VA Boston Healthcare Syst, Boston, MA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A10045 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738702212 ER PT J AU Leuschner, F Ueno, T Gorbatov, R Higgins, JM Pittet, MJ Swirski, FK Weissleder, R Nahrendorf, M AF Leuschner, Florian Ueno, Takuya Gorbatov, Rostic Higgins, John M. Pittet, Mikael J. Swirski, Filip K. Weissleder, Ralph Nahrendorf, Matthias TI Fate Mapping of Monocytes Shows Rapid Turnover Kinetics in Acute Myocardial Infarction SO CIRCULATION LA English DT Meeting Abstract DE Myocardial infarction; Inflammation; Immune system C1 Massachusetts Gen Hosp, Cntr Syst Biol, Boston, MA 02114 USA. Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9029 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701258 ER PT J AU Leuschner, F Rauch, PJ Gorbatov, R Marinelli, B Lee, WW Sena, B Panizzi, P Libby, P Pittet, MJ Swirski, FK Weissleder, R Nahrendorf, M AF Leuschner, Florian Rauch, Philipp J. Gorbatov, Rostic Marinelli, Brett Lee, Won Woo Sena, Brena Panizzi, Peter Libby, Peter Pittet, Mikael J. Swirski, Filip K. Weissleder, Ralph Nahrendorf, Matthias TI Serial in vivo Imaging Reveals a Key Function for Splenic Monocytes in Infarct Healing SO CIRCULATION LA English DT Meeting Abstract DE Myocardial infarction; Immunology; Remodeling C1 [Leuschner, Florian; Rauch, Philipp J.; Gorbatov, Rostic; Marinelli, Brett; Lee, Won Woo; Sena, Brena; Panizzi, Peter; Pittet, Mikael J.; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias] Massachusetts Gen Hosp, Cntr Syst Biol, Boston, MA 02114 USA. [Leuschner, Florian; Rauch, Philipp J.; Gorbatov, Rostic; Marinelli, Brett; Lee, Won Woo; Sena, Brena; Panizzi, Peter; Pittet, Mikael J.; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias] Harvard Univ, Sch Med, Boston, MA USA. [Libby, Peter] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9018 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701256 ER PT J AU Li, Q Chitilian, H Liu, YH Kacmarek, RM Jiang, YD AF Li, Qian Chitilian, Hovig Liu, Yanhong Kacmarek, Robert M. Jiang, Yandong TI Arterial Oxygen Saturation May Be the Limiting Factor for O-2 Delivery During Compression-Only CPR SO CIRCULATION LA English DT Meeting Abstract DE Cardiac arrest; Cardiopulmonary resuscitation; Oxygen uptake; Ventilation C1 [Li, Qian; Chitilian, Hovig; Liu, Yanhong; Kacmarek, Robert M.; Jiang, Yandong] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A188 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738700173 ER PT J AU Liu, HX Hou, JB Jia, HB Kong, JY Sun, R Gao, GR Zhang, SS Yu, B Jang, IK AF Liu, Haixia Hou, Jingbo Jia, Haibo Kong, Junying Sun, Rong Gao, Guangren Zhang, Shaosong Yu, Bo Jang, Ik-Kyung TI Differences in Culprit Plaque Morphology in Patients with ST Elevation Myocardial Infarction versus Non ST Elevation Acute Coronary Syndrome: Optical Coherence Tomography Study SO CIRCULATION LA English DT Meeting Abstract DE Acute coronary syndromes; Plaque; Myocardial infarction; NSTEMI; Myocardial infarction, STEMI; Plaque rupture C1 [Liu, Haixia; Hou, Jingbo; Jia, Haibo; Kong, Junying; Sun, Rong; Gao, Guangren; Yu, Bo] Harbin Med Coll, Affiliated Hosp 2, Harbin, Peoples R China. [Zhang, Shaosong] St Jude Med, LightLab Imaging, Westford, MA USA. [Jang, Ik-Kyung] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12399 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704202 ER PT J AU Loffredo, FS Steinhauser, ML Tian, J Gannon, J Shadrach, J Miller, C Pizzimenti, CL Wagers, AJ Lee, RT AF Loffredo, Francesco S. Steinhauser, Matthew L. Tian, Jack Gannon, Joseph Shadrach, Jennifer Miller, Christine Pizzimenti, Christie L. Wagers, Amy J. Lee, Richard T. TI Circulating Systemic Factors From Young Mice Reverse Age-Related Cardiac Hypertrophy SO CIRCULATION LA English DT Meeting Abstract DE Aging; Cardiac hypertrophy; Heart failure; Remodeling C1 [Lee, Richard T.] Harvard Univ, Sch Med, BWH, Harvard Stem Cell Inst, Cambridge, MA 02138 USA. [Shadrach, Jennifer; Miller, Christine; Wagers, Amy J.] Harvard Univ, Sch Med, Harvard Stem Cell Inst, Joslin Diabet Cntr, Boston, MA USA. RI Loffredo, Francesco/F-6638-2014 OI Loffredo, Francesco/0000-0001-5911-780X NR 0 TC 0 Z9 0 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16496 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708058 ER PT J AU Lubitz, S Moser, C Sullivan, L Rienstra, M Fontes, J Villalon, M Pai, MJ Magnani, J Yin, XY Levy, D Pencina, M Larson, M Ellinor, P Benjamin, E AF Lubitz, Steven Moser, Carlee Sullivan, Lisa Rienstra, Michiel Fontes, Joao Villalon, Mark Pai, Manju Magnani, Jared Yin, Xiaoyan Levy, Daniel Pencina, Michael Larson, Martin Ellinor, Patrick Benjamin, Emelia TI Atrial Fibrillation Patterns in the Community and Risks of Stroke, Heart Failure, or Death SO CIRCULATION LA English DT Meeting Abstract DE Atrial fibrillation; Epidemiology; Prognosis; Longitudinal studies; Risk factors C1 [Lubitz, Steven; Ellinor, Patrick] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA. [Moser, Carlee; Sullivan, Lisa; Pencina, Michael; Larson, Martin] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. [Rienstra, Michiel] Massachusetts Gen Hosp, Cardiovasc Rsch Cntr, Charlestown, MA USA. [Fontes, Joao; Magnani, Jared] Boston Univ, Sch Med, Dept Cardiol, Boston, MA 02118 USA. [Villalon, Mark; Pai, Manju] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Yin, Xiaoyan; Benjamin, Emelia] Boston Univ, Framingham Heart Study, Framingham, MA USA. [Levy, Daniel] NHLBI, Framingham Heart Study, Framingham, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13665 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705247 ER PT J AU Mahaffey, KW White, HD Nessel, CC Goodman, SG Piccini, JP Patel, MR Paolini, JF Becker, RC Halperin, JL Hacke, W Singer, DE Hankey, GJ Califf, RM Fox, KA Breithardt, G AF Mahaffey, Kenneth W. White, Harvey D. Nessel, Christopher C. Goodman, Shaun G. Piccini, Jonathan P. Patel, Manesh R. Paolini, John F. Becker, Richard C. Halperin, Jonathan L. Hacke, Werner Singer, Daniel E. Hankey, Graeme J. Califf, Robert M. Fox, Keith A. Breithardt, Gunter TI Ischemic Cardiac Outcomes in Patients with AF Treated with Vitamin K Antagonism or Factor Xa Inhibition: Results from the ROCKET AF Trial SO CIRCULATION LA English DT Meeting Abstract DE Myocardial infarction C1 [Mahaffey, Kenneth W.; Piccini, Jonathan P.; Patel, Manesh R.; Becker, Richard C.] Duke Univ Med Cntr, Duke Clin Rsch Inst, Durham, NC USA. [White, Harvey D.] Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand. [Nessel, Christopher C.] Johnson & Johnson Pharmaceut Rsch & Dev LLC, Raritan, NJ USA. [Goodman, Shaun G.] Univ Toronto, St Michaels Hosp, Canadian Heart Rsch Cntr, Toronto, ON M5B 1W8, Canada. [Paolini, John F.] Bayer HealthCare, Montville, NJ USA. [Halperin, Jonathan L.] Mt Sinai Med Cntr, New York, NY USA. [Hacke, Werner] Univ Heidelberg, Heidelberg, Germany. [Singer, Daniel E.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Hankey, Graeme J.] Royal Perth Hosp, Perth, WA, Australia. [Califf, Robert M.] Duke Univ Med Cntr, Duke Translat Med Inst, Durham, NC USA. [Fox, Keith A.] Univ Edinburgh, Royal Infirm Edinburgh, Edinburgh, Midlothian, Scotland. [Breithardt, Gunter] Hosp Univ Munster, Munster, Germany. RI Hankey, Graeme /H-4968-2014 OI Hankey, Graeme /0000-0002-6044-7328 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13482 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705175 ER PT J AU Mak, GS Khan, AM Arora, P Martinez, A Ryan, A Newton-Cheh, C Wang, TJ Scherrer-Crosbie, M AF Mak, Gary S. Khan, Abigail May Arora, Pankaj Martinez, Andrew Ryan, Allicia Newton-Cheh, Christopher Wang, Thomas J. Scherrer-Crosbie, Marielle TI Effects of Subacute and Acute Salt Loading on Diastolic Function in Young Normotensive Individuals SO CIRCULATION LA English DT Meeting Abstract DE Diastolic function; Sodium; Tissue doppler; Echocardiography C1 [Mak, Gary S.; Khan, Abigail May; Arora, Pankaj; Martinez, Andrew; Ryan, Allicia; Newton-Cheh, Christopher; Wang, Thomas J.; Scherrer-Crosbie, Marielle] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. RI Arora, Pankaj/F-3437-2011 OI Arora, Pankaj/0000-0003-2420-3550 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13142 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705058 ER PT J AU Malhotra, R Derwall, M Spagnolli, E Beppu, Y Shakartzi, HR Buys, ES Yu, PB Bloch, KD AF Malhotra, Rajeev Derwall, Matthias Spagnolli, Ester Beppu, Yuko Shakartzi, Hannah R. Buys, Emmanuel S. Yu, Paul B. Bloch, Kenneth D. TI Bone Morphogenetic Protein Signaling is Required for Vascular Calcification in a Murine Model of Matrix GLA Protein Deficiency SO CIRCULATION LA English DT Meeting Abstract DE Calcification; Vascular disease; Aortic diseases; Molecular biology C1 [Malhotra, Rajeev; Beppu, Yuko; Shakartzi, Hannah R.; Yu, Paul B.; Bloch, Kenneth D.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16812 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708165 ER PT J AU Martin, BC Casciano, JP Kwong, WJ Singer, DE AF Martin, Bradley C. Casciano, Julian P. Kwong, W. J. Singer, Daniel E. TI Can a Model-Based Decision Support Tool Improve Anticoagulation Outcomes for Atrial Fibrillation? Results From a Large Database Cohort SO CIRCULATION LA English DT Meeting Abstract DE Anticoagulation; Atrial fibrillation; Stroke; Risk factors; Disease management C1 [Martin, Bradley C.] Univ Arkansas Med Sci, Coll Pharm, Div Pharmaceut Evaluat & Policy, Little Rock, AR 72205 USA. [Casciano, Julian P.] eMAX Hlth Syst LLC, eMAX, White Plains, NY USA. [Kwong, W. J.] Daiichi Sankyo Inc, Hlth Econ & Outcomes Rsch, Parsippany, NJ USA. [Singer, Daniel E.] Massachusetts Gen Hosp, Div Gen Med, Clin Epidemiol Unit, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16467 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708047 ER PT J AU Maurovich-Horvat, P Schlett, C Alkadhi, H Kriegel, M Nakano, M Otsuka, F Stolzmann, P Scheffel, H Ferencik, M Virmani, R Hoffmann, U AF Maurovich-Horvat, Pal Schlett, Christopher Alkadhi, Hatem Kriegel, Matthias Nakano, Masataka Otsuka, Fumiyuki Stolzmann, Paul Scheffel, Hans Ferencik, Maros Virmani, Renu Hoffmann, Udo TI Plaque Attenuation Pattern Assessment to Predict Advanced Atherosclerotic Lesions in Coronary CT Angiography SO CIRCULATION LA English DT Meeting Abstract DE Coronary artery disease; CT angiography; Cardiac imaging; Vulnerable plaque C1 [Maurovich-Horvat, Pal] Semmelweis Univ, Heart Cntr, Budapest, Hungary. [Schlett, Christopher; Alkadhi, Hatem; Kriegel, Matthias; Stolzmann, Paul; Scheffel, Hans; Hoffmann, Udo] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cardiac MR PET CT Program, Boston, MA USA. [Nakano, Masataka; Otsuka, Fumiyuki; Virmani, Renu] CV Path Inst Inc, CV Path, Gaithersburg, MD USA. [Ferencik, Maros] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16969 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708224 ER PT J AU McCabe, JM Armstrong, EJ Ku, I Bhave, PD Hoffmayer, KS Kinlay, S Marcus, GM Stein, JC Ganz, P AF McCabe, James M. Armstrong, Ehrin J. Ku, Ivy Bhave, Prashant D. Hoffmayer, Kurt S. Kinlay, Scott Marcus, Gregory M. Stein, John C. Ganz, Peter TI Physician Accuracy in Interpreting Potential ST-Segment Elevation Myocardial Infarction Electrocardiograms in the Absence of Clinical Context SO CIRCULATION LA English DT Meeting Abstract DE STEMI; Electrocardiography; Quality assessment C1 [McCabe, James M.; Armstrong, Ehrin J.; Ku, Ivy; Bhave, Prashant D.; Hoffmayer, Kurt S.; Marcus, Gregory M.; Stein, John C.] UCSF, San Francisco, CA USA. [Kinlay, Scott] Brigham & Womens Hosp, Div Cardiovasc, VA Boston Healthcare Syst, Boston, MA 02115 USA. [Kinlay, Scott] Harvard Univ, Sch Med, Boston, MA USA. [Ganz, Peter] UCSF, San Francisco Gen Hosp, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A10953 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738703093 ER PT J AU McCabe, JM Armstrong, EJ Hoffmayer, KS Bhave, PD Garg, S Patel, A Stein, JC Kinlay, S Ganz, P AF McCabe, James M. Armstrong, Ehrin J. Hoffmayer, Kurt S. Bhave, Prashant D. Garg, Sonia Patel, Ateet Stein, John C. Kinlay, Scott Ganz, Peter TI Factors Associated with Delays in Primary PCI and Cardiac Catheterization Laboratory Activation for ST-Segment Elevation Myocardial Infarctions; A Report From the Activate-SF Registry SO CIRCULATION LA English DT Meeting Abstract DE STEMI; Emergency care; Quality improvement; Efficacy C1 [McCabe, James M.; Armstrong, Ehrin J.; Hoffmayer, Kurt S.; Bhave, Prashant D.; Garg, Sonia; Patel, Ateet; Stein, John C.] UCSF, San Francisco, CA USA. [Kinlay, Scott] Brigham & Womens Hosp, Div Cardiovasc, VA Boston Healthcare Syst, Boston, MA 02115 USA. [Kinlay, Scott] Harvard Univ, Sch Med, Boston, MA USA. [Ganz, Peter] UCSF, San Francisco Gen Hosp, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A10961 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738703095 ER PT J AU Mehrotra, P Mak, G Jansen, K Zeng, X Flynn, A Passeri, J Hung, J AF Mehrotra, Praveen Mak, Gary Jansen, Katrijn Zeng, Xin Flynn, Aidan Passeri, Jon Hung, Judy TI Cutoff of 1.0 cm(2) For Severe Aortic Stenosis? A Case for Redefining this Cutoff Based on Eccentricity of LVOT Geometry SO CIRCULATION LA English DT Meeting Abstract DE Aortic valve stenosis C1 [Mehrotra, Praveen; Mak, Gary; Jansen, Katrijn; Zeng, Xin; Flynn, Aidan; Passeri, Jon; Hung, Judy] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A18366 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738709149 ER PT J AU Mehrotra, P Jansen, K Picard, MH Hung, J AF Mehrotra, Praveen Jansen, Katrijn Picard, Michael H. Hung, Judy TI Co-Existing Mitral Regurgitation in Significant Aortic Stenosis: Adverse Impact on Left Ventricular Geometry, Function and Patient Outcome SO CIRCULATION LA English DT Meeting Abstract DE Aortic valve stenosis; Mitral regurgitation C1 [Mehrotra, Praveen; Jansen, Katrijn; Picard, Michael H.; Hung, Judy] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A17436 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708369 ER PT J AU Mehrotra, P Jansen, K Picard, M Hung, J AF Mehrotra, Praveen Jansen, Katrijn Picard, Michael Hung, Judy TI Preserved Ejection Fraction With Low Gradient and Low Flow Aortic Stenosis: A True Entity or Misclassification? Can Left Ventricular Remodeling Differences Improve Characterization of This Group? SO CIRCULATION LA English DT Meeting Abstract DE Aortic valve stenosis C1 [Mehrotra, Praveen; Jansen, Katrijn; Picard, Michael; Hung, Judy] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16547 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708075 ER PT J AU Miller, PS Evangelista, LS Giger, JN Martinez-Maza, O Corvera-Tindel, T Doering, LV AF Miller, Pamela S. Evangelista, Lorraine S. Giger, Joyce Newman Martinez-Maza, Otoniel Corvera-Tindel, Teresita Doering, Lynn V. TI Bypassing Troubles: Relation of Exhaustion, Viral Burden, and Inflammation to Depressive Symptoms After Cardiac Surgery SO CIRCULATION LA English DT Meeting Abstract DE Cardiac surgery; Coronary artery disease; Inflammation C1 [Miller, Pamela S.] Univ Calif San Francisco, Sch Nursing, San Francisco, CA 94143 USA. [Evangelista, Lorraine S.] Univ Calif Irvine, Coll Hlth Sci, Program Nursing Sci, Irvine, CA USA. [Giger, Joyce Newman; Doering, Lynn V.] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA. [Corvera-Tindel, Teresita] Vet Affairs Greater Los Angeles Hlth Care Syst, Nursing Rsch Dept, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A14769 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738706205 ER PT J AU Miller, PS Evangelista, LS Giger, JN Corvera-Tindel, T Martinez-Maza, O Dracup, K Doering, LV AF Miller, Pamela S. Evangelista, Lorraine S. Giger, Joyce Newman Corvera-Tindel, Teresita Martinez-Maza, Otoniel Dracup, Kathleen Doering, Lynn V. TI Who is at Risk for Exhaustion Post-Cardiac Surgery SO CIRCULATION LA English DT Meeting Abstract DE Coronary heart disease; Cardiac surgery C1 [Miller, Pamela S.; Dracup, Kathleen] Univ Calif San Francisco, Sch Nursing, San Francisco, CA 94143 USA. [Evangelista, Lorraine S.] Univ Calif Irvine, Coll Hlth Sci, Program Nursing Sci 2, Irvine, CA USA. [Giger, Joyce Newman; Doering, Lynn V.] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA. [Corvera-Tindel, Teresita] Vet Affairs Greater Los Angeles Hlth Care Syst, Nursing Rsch Dept, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A14574 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738706159 ER PT J AU Murabito, JM Pedley, A Massaro, JM Vasan, RS Glazer, NL Hoffman, U Fox, CS AF Murabito, Joanne M. Pedley, Alison Massaro, Joseph M. Vasan, Ramachandran S. Glazer, Nicole L. Hoffman, Udo Fox, Caroline S. TI The Relation of Physical Activity With Accelerometry and Adipose Tissue Depots in a Community-Based Sample of Adults: The Framingham Third Generation Cohort SO CIRCULATION LA English DT Meeting Abstract DE Physical activity; Adipose; Obesity C1 [Murabito, Joanne M.] Boston Univ, Sch Med, Gen Internal Med Sect, Framingham, MA USA. [Fox, Caroline S.] NHLBI, Framingham Heart Study, Div Endocrinol, Framingham, MA USA. [Massaro, Joseph M.] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA. [Hoffman, Udo] Massachusetts Gen Hosp, Dept Cardiac MR PET CT, Boston, MA 02114 USA. [Hoffman, Udo; Fox, Caroline S.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13457 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705164 ER PT J AU Murray, DR Mummidi, S Valente, AJ Dinarello, CA Delafontaine, P Chandrasekar, B AF Murray, David R. Mummidi, Srinivas Valente, Anthony J. Dinarello, Charles A. Delafontaine, Patrice Chandrasekar, Bysani TI IL-18 Binding Protein (IL-18BP) Inhibits beta-AR Induced Cardiomyocyte Hypertrophy in vitro and Myocardial Hypertrophy in vivo SO CIRCULATION LA English DT Meeting Abstract DE Hypertrophic cardiomyopathy; Heart failure; Inflammation; Signal transduction; Cardioprotection C1 [Murray, David R.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. [Mummidi, Srinivas; Valente, Anthony J.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Dinarello, Charles A.] Univ Colarado, Aurora, CO USA. [Delafontaine, Patrice; Chandrasekar, Bysani] Tulane Univ, Sch Med, Inst Heart & Vasc, New Orleans, LA 70112 USA. RI Mummidi, Srinivas/C-1004-2008 OI Mummidi, Srinivas/0000-0002-4068-6380 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A8393 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701090 ER PT J AU Noseworthy, PA Peloso, GM Hwang, SJ Larson, MG Levy, D O'Donnell, CJ Newton-Cheh, C AF Noseworthy, Peter A. Peloso, Gina M. Hwang, Shih-Jen Larson, Martin G. Levy, Daniel O'Donnell, Christopher J. Newton-Cheh, Christopher TI QT Interval Duration and Incident Mortality in the Framingham Heart Study SO CIRCULATION LA English DT Meeting Abstract DE Qt interval; Sudden cardiac death; Heart rate/Heart rate variability C1 [Noseworthy, Peter A.; Newton-Cheh, Christopher] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Peloso, Gina M.; Hwang, Shih-Jen; Larson, Martin G.; Levy, Daniel; O'Donnell, Christopher J.] NHLBI, Framingham Heart Study, Framingham, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9138 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701272 ER PT J AU Otani, K Takeuchi, M Kaku, K Haruki, N Yoshitani, H Levine, RA Otsuji, Y AF Otani, Kyoko Takeuchi, Masaaki Kaku, Kyoko Haruki, Nobuhiko Yoshitani, Hidetoshi Levine, Robert A. Otsuji, Yutaka TI Evidence of Vicious Cycle in Mitral Regurgitation with Prolapse: Secondary Tethering Due to Primary Prolapse Demonstrated by 3-Dimensional Echocardiography Exacerbates Regurgitation SO CIRCULATION LA English DT Meeting Abstract DE Mitral valve disease; Mitral regurgitation C1 [Otani, Kyoko; Takeuchi, Masaaki; Kaku, Kyoko; Haruki, Nobuhiko; Yoshitani, Hidetoshi; Otsuji, Yutaka] Univ Occupat & Environm Hlth, Dept Internal Med 2, Kitakyushu, Fukuoka 807, Japan. [Levine, Robert A.] Massachusetts Gen Hosp, Cardiac Ultrasound Lab, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A17938 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738709055 ER PT J AU Pape, L Awais, M Suzuki, T Trimarchi, S Evangelista, A Myrmel, T Larsen, M Harris, KM Greason, K Di Eusanio, M Montgomery, D Eagle, KA Nienaber, CA Isselbacher, EM O'Gara, P AF Pape, Linda Awais, Mazen Suzuki, Toru Trimarchi, Santi Evangelista, Arturo Myrmel, Truls Larsen, Magnus Harris, Kevin M. Greason, Kevin Di Eusanio, Marco Montgomery, Daniel Eagle, Kim A. Nienaber, Christoph A. Isselbacher, Eric M. O'Gara, Patrick TI Trends in the Presentation, Diagnosis and Outcomes of Acute Aortic Dissection Over 15 Years, From the International Registry of Acute Aortic Dissection (IRAD). SO CIRCULATION LA English DT Meeting Abstract DE Aortic diseases; Outcomes C1 [Pape, Linda] Univ Massachusetts Hosp, Worcester, MA USA. [Awais, Mazen; Montgomery, Daniel; Eagle, Kim A.] Univ Michigan, Ann Arbor, MI 48109 USA. [Suzuki, Toru] Univ Tokyo, Tokyo, Japan. [Trimarchi, Santi] IRCCS Policlin San Donato, San Donato Milanese, Italy. [Evangelista, Arturo] Hosp Gen Univ Vall DHebron, Barcelona, Spain. [Myrmel, Truls; Larsen, Magnus] Univ Tromso Hosp, N-9012 Tromso, Norway. [Harris, Kevin M.] Univ Minnesota, Minneapolis Heart Inst, Minneapolis, MN USA. [Greason, Kevin] Mayo Clin, Rochester, MN USA. [Di Eusanio, Marco] Univ Hosp S Orsola, Bologna, Italy. [Nienaber, Christoph A.] Univ Hosp Eppendorf Rostock, Rostock, Germany. [Isselbacher, Eric M.] Massachusetts Gen Hosp, Thorac Aort Cntr, Boston, MA 02114 USA. [O'Gara, Patrick] Brigham & Womens Hosp, Boston, MA 02115 USA. RI Trimarchi, Santi/J-7361-2016 OI Trimarchi, Santi/0000-0001-5996-3264 NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16892 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708199 ER PT J AU Parikh, VN Jin, RC Rabello, S Gulbahce, N Hale, AE Shaik, RS Waxman, AB Hartner, JC Fujiwara, Y Orkin, SH Barabasi, AL Loscalzo, J Chan, SY AF Parikh, Victoria N. Jin, Richard C. Rabello, Sabrina Gulbahce, Natali Hale, Andrew E. Shaik, Rahamtullah S. Waxman, Aaron B. Hartner, Jochen C. Fujiwara, Yuko Orkin, Stuart H. Barabasi, Albert-Laszlo Loscalzo, Joseph Chan, Stephen Y. TI A Systems-Biology Approach Reveals That MicroRNA-21 Integrates Diverse Pathogenic Signaling to Control Pulmonary Hypertension SO CIRCULATION LA English DT Meeting Abstract DE Microrna; Pulmonary hypertension; Endothelial; Endothelial progenitor cell C1 [Shaik, Rahamtullah S.] Brigham & Womens Hosp, Med Pulm & Crit Care Div, Boston, MA 02115 USA. [Parikh, Victoria N.; Jin, Richard C.; Hale, Andrew E.; Loscalzo, Joseph; Chan, Stephen Y.] Harvard Univ, Sch Med, Boston, MA USA. [Rabello, Sabrina; Gulbahce, Natali; Barabasi, Albert-Laszlo] Northeastern Univ, Cntr Complex Network Rsch, Boston, MA 02115 USA. [Waxman, Aaron B.] Brigham & Womens Hosp, Div Pulm, Boston, MA 02115 USA. [Hartner, Jochen C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Orkin, Stuart H.] Childrens Hosp, Div Hematol, Boston, MA 02115 USA. [Orkin, Stuart H.] Howard Hughes Med Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13395 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705143 ER PT J AU Park, MY Altman, RK Orencole, M Kumar, P Parks, KA Heist, EK Singh, J Picard, MH AF Park, Mi Young Altman, Robert K. Orencole, Mary Kumar, Prabhat Parks, Kimberly Ann Heist, E. Kevin Singh, Jagmeet Picard, Michael H. TI Characteristics of Responders to Cardiac Resynchronization Therapy: Real World Observations from a Multidisciplinary Cardiac Resynchronization Program SO CIRCULATION LA English DT Meeting Abstract DE Resynchronization therapy; Heart failure; Echocardiography C1 [Park, Mi Young; Altman, Robert K.; Orencole, Mary; Kumar, Prabhat; Parks, Kimberly Ann; Heist, E. Kevin; Singh, Jagmeet; Picard, Michael H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A11035 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738703113 ER PT J AU Park, MY Altman, RK Orencole, M Kumar, P Singh, JP Picard, MH AF Park, Mi Young Altman, Robert K. Orencole, Mary Kumar, Prabhat Singh, Jagmeet P. Picard, Michael H. TI Identification of Response to Cardiac Resynchronization Therapy by Radial Strain: Influence of Cardiomyopathy Type SO CIRCULATION LA English DT Meeting Abstract DE Echocardiography; Resynchronization therapy; Heart failure C1 [Park, Mi Young; Altman, Robert K.; Orencole, Mary; Kumar, Prabhat; Singh, Jagmeet P.; Picard, Michael H.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9619 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738702077 ER PT J AU Pong, T Scherrer-Crosbie, M Bloch, KD Huang, PL AF Pong, Terrence Scherrer-Crosbie, Marielle Bloch, Kenneth D. Huang, Paul L. TI eNOS-Phosphorylation Regulates Myocardial Perfusion and the Outcome of Ischemic Postconditioning SO CIRCULATION LA English DT Meeting Abstract DE Myocardial perfusion; Nitric oxide synthase; Cardioprotection; Myocardial infarction; Echocardiography C1 [Pong, Terrence] Harvard MIT, Div Hlth Sci & Technol, Cambridge, MA USA. [Scherrer-Crosbie, Marielle; Bloch, Kenneth D.; Huang, Paul L.] Massachusetts Gen Hosp, Cardiovasc Rsch Cntr, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16375 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708012 ER PT J AU Pulido, JN Cook, DJ Thompson, JE Sundt, T Rohleder, TR Roger, VL AF Pulido, Juan N. Cook, David J. Thompson, Jeffrey E. Sundt, Thor Rohleder, Thomas R. Roger, Veronique L. TI Care Standardization in the Cardiac Surgical Intensive Care Unit: Clinical Outcome and Value SO CIRCULATION LA English DT Meeting Abstract DE Quality improvement; Systems of care; Cardiac surgery; Healthcare innovation C1 [Pulido, Juan N.; Cook, David J.; Thompson, Jeffrey E.; Rohleder, Thomas R.; Roger, Veronique L.] Mayo Clin Coll Med, Rochester, MN USA. [Sundt, Thor] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16823 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708172 ER PT J AU Qi, QB Meigs, JB Rexrode, KM Hu, FB Qi, L AF Qi, Qibin Meigs, James B. Rexrode, Kathryn M. Hu, Frank B. Qi, Lu TI Genetic Predisposition to Diabetes Associated With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies SO CIRCULATION LA English DT Meeting Abstract DE Cardiovascular disease; Genetics; Type 2 Diabetes C1 [Qi, Qibin; Hu, Frank B.; Qi, Lu] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Meigs, James B.] Massachusetts Gen Hosp, Div Gen Med, Boston, MA 02114 USA. [Meigs, James B.] Massachusetts Gen Hosp, Cntr Human Genet Rsch, Boston, MA 02114 USA. [Meigs, James B.] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA. [Rexrode, Kathryn M.] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13954 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705355 ER PT J AU Ramani, R Lemster, B Gorcsan, J Alexis, J Torre-Amione, G Dec, GW Liu, P McTiernan, C McNamara, DM AF Ramani, Ravi Lemster, Bonnie Gorcsan, John, III Alexis, Jeffrey Torre-Amione, Guillermo Dec, G. William Liu, Peter McTiernan, Charles McNamara, Dennis M. CA IMAC Investigators TI Differential Expression of Serum MicroRNAs is Associated with Recovery from Heart Failure SO CIRCULATION LA English DT Meeting Abstract DE Heart failure; Microrna C1 [Ramani, Ravi; Lemster, Bonnie; Gorcsan, John, III; McTiernan, Charles; McNamara, Dennis M.] Univ Pittsburgh, Inst Heart & Vasc, Pittsburgh, PA USA. [Alexis, Jeffrey] Univ Rochester, Rochester, NY USA. [Torre-Amione, Guillermo] Methodist Hosp, Houston, TX 77030 USA. [Dec, G. William] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Liu, Peter] Univ Toronto, Inst Heart, Toronto, ON, Canada. NR 0 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13104 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705043 ER PT J AU Ruff, CT Bhatt, DL Steg, PG Crowley, K Contant, CF Shinya, G AF Ruff, Christian T. Bhatt, Deepak L. Steg, Ph. Gabriel Crowley, Kevin Contant, Charles F. Shinya, Goto CA REACH Registry Investigators TI Long-Term Cardiovascular Outcomes in Patients with Atrial Fibrillation and Atherothrombosis in the REACH Registry SO CIRCULATION LA English DT Meeting Abstract DE Atrial fibrillation; Arteriosclerosis; Epidemiology C1 [Bhatt, Deepak L.] Brigham & Womens Hosp, TIMI Study Grp, Div Cardiovasc, VA Boston Healthcare Syst, Boston, MA 02115 USA. [Steg, Ph. Gabriel] Univ Paris Diderot, AP HP, INSERM U698, Paris, France. [Shinya, Goto] Tokai Univ, Dept Med, Tokyo 151, Japan. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12822 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704326 ER PT J AU Ruggiero, NJ Hynes, BG Kennedy, KF Garasic, JM Rosenfield, K AF Ruggiero, Nicholas J., II Hynes, Brian G. Kennedy, Kevin F. Garasic, Joseph M. Rosenfield, Kenneth TI The Impact of Timing on Carotid Artery Stenting in the Symptomatic Population SO CIRCULATION LA English DT Meeting Abstract DE Carotid arteries; Stent; Outcomes C1 [Ruggiero, Nicholas J., II] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA. [Hynes, Brian G.; Garasic, Joseph M.; Rosenfield, Kenneth] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Kennedy, Kevin F.] Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO 64110 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A14363 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738706094 ER PT J AU Scirica, BM Bhatt, DL Ohman, EM Smith, SC Eagle, KA Goto, S Crowley, K Contant, C Steg, PG AF Scirica, Benjamin M. Bhatt, Deepak L. Ohman, E. M. Smith, Sidney C., Jr. Eagle, Kim A. Goto, Shinya Crowley, Kevin Contant, Charles Steg, Ph G. TI A History of Stable Angina Significantly Increases the Risk of Cardiovascular Death and Myocardial Infarction in the REACH Registry SO CIRCULATION LA English DT Meeting Abstract DE Ischemic heart disease; Outcomes C1 [Scirica, Benjamin M.; Crowley, Kevin; Contant, Charles] Brigham & Womens Hosp, Dept Med, CV Div, TIMI Study Grp, Boston, MA 02115 USA. [Ohman, E. M.] Duke Univ Med Cntr, Duke Clin Rsch Inst, Durham, NC USA. [Smith, Sidney C., Jr.] Univ N Carolina, Cntr Cardiovasc Sci & Med, Chapel Hill, NC USA. [Eagle, Kim A.] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA. [Goto, Shinya] Tokai Univ, Dept Med Cardiol, Tokyo 151, Japan. [Steg, Ph G.] Univ Paris Diderot, INSERM, U698, Paris, France. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13420 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705149 ER PT J AU Seifarth, H Schlett, CL Lehman, SJ Bamberg, F Donnelly, P Januzzi, JL Truong, QA Koenig, W Hoffmann, U AF Seifarth, Harald Schlett, Christopher L. Lehman, Sam J. Bamberg, Fabian Donnelly, Patrick Januzzi, James L., Jr. Truong, Quynh A. Koenig, Wolfgang Hoffmann, Udo TI Levels of Inflammatory Biomarkers Correlate with Plaque Progression as Measured in Coronary CT Angiography SO CIRCULATION LA English DT Meeting Abstract DE Cardiovascular imaging; Cardiac CT; Coronary artery disease; Biomarkers; Inflammation C1 [Seifarth, Harald; Schlett, Christopher L.; Lehman, Sam J.; Donnelly, Patrick; Truong, Quynh A.; Hoffmann, Udo] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Bamberg, Fabian] Univ Munich, Univ Hosps Grosshadern, Dept Radiol, Munich, Germany. [Januzzi, James L., Jr.] Massachusetts Gen Hosp, Cardiac Intens Care Unit, Boston, MA 02114 USA. [Koenig, Wolfgang] Univ Ulm, Med Cntr, Dept Internal Med Cardiol 2, Ulm, Germany. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13035 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705016 ER PT J AU Shah, R Zilinski, J Abtahian, F Das, S AF Shah, Ravi Zilinski, Jodi Abtahian, Farhad Das, Saumya TI A Novel Mutation in HERG Leading to an LQTS Overlap Syndrome SO CIRCULATION LA English DT Meeting Abstract DE Genetics; Electrophysiology C1 [Shah, Ravi; Zilinski, Jodi; Abtahian, Farhad; Das, Saumya] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A8129 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701053 ER PT J AU Singer, DE Hellkamp, AS Halperin, JL Mahaffey, KW Becker, RC Breithardt, G Hankey, GJ Hacke, W Patel, MR Califf, RM Fox, KA AF Singer, Daniel E. Hellkamp, Anne S. Halperin, Jonathan L. Mahaffey, Kenneth W. Becker, Richard C. Breithardt, Gunter Hankey, Graeme J. Hacke, Werner Patel, Manesh R. Califf, Robert M. Fox, Keith A. TI Individual and Regional Determinants of Time in Therapeutic Range Among Patients Randomized to Warfarin in the ROCKET AF Trial of Rivaroxaban SO CIRCULATION LA English DT Meeting Abstract DE Anticoagulation C1 [Singer, Daniel E.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Hellkamp, Anne S.; Mahaffey, Kenneth W.; Becker, Richard C.; Patel, Manesh R.] Duke Univ Med Cntr, Duke Clin Rsch Inst, Durham, NC USA. [Halperin, Jonathan L.] Mt Sinai Med Cntr, New York, NY USA. [Breithardt, Gunter] Hosp Univ Munster, Munster, Germany. [Hankey, Graeme J.] Royal Perth Hosp, Perth, WA, Australia. [Hacke, Werner] Univ Heidelberg, Heidelberg, Germany. [Califf, Robert M.] Duke Univ Med Cntr, Duke Translat Med Inst, Durham, NC USA. [Fox, Keith A.] Univ Edinburgh, Royal Infirm Edinburgh, Edinburgh, Midlothian, Scotland. RI Hankey, Graeme /H-4968-2014 OI Hankey, Graeme /0000-0002-6044-7328 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16169 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707319 ER PT J AU Sinner, M Greiner, MA Mi, XJ Hernandez, AF Jensen, PN Piccini, JP Setoguchi, S Walkey, AJ Heckbert, SR Benjamin, EJ Curtis, LH AF Sinner, Moritz Greiner, Melissa A. Mi, Xioajuan Hernandez, Adrian F. Jensen, Paul N. Piccini, Jonathan P. Setoguchi, Soko Walkey, Allan J. Heckbert, Susan R. Benjamin, Emelia J. Curtis, Lesley H. TI Guideline Recommended Evaluation in Patients with a First Episode of Atrial Fibrillation SO CIRCULATION LA English DT Meeting Abstract DE Atrial fibrillation; Guidelines; Quality of medical care; Epidemiologic methods C1 [Sinner, Moritz] Massachusetts Gen Hosp, Cardiovasc Rsch Cntr, Charlestown, MA USA. [Greiner, Melissa A.; Mi, Xioajuan; Hernandez, Adrian F.; Piccini, Jonathan P.; Setoguchi, Soko; Curtis, Lesley H.] Duke Univ, Sch Med, Duke Clin Rsch Inst, Durham, NC USA. [Jensen, Paul N.; Heckbert, Susan R.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Walkey, Allan J.] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA. [Benjamin, Emelia J.] NHLBI, Framingham Heart Study, Framingham, MA USA. [Benjamin, Emelia J.] Boston Univ, Framingham Heart Study, Framingham, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A8440 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701105 ER PT J AU Tang, WHW Felker, GM Hernandez, AF Hsu, AP Gottlieb, SS Voors, AA Butler, J Metra, M Anker, SD Troughton, RW McMurray, JJ Armstrong, PW Massie, BM Califf, RM O'Connor, CM Starling, RC AF Tang, W. H. Wilson Felker, G. Michael Hernandez, Adrian F. Hsu, Amy P. Gottlieb, Stephen S. Voors, Adriaan A. Butler, Javed Metra, Marco Anker, Stefan D. Troughton, Richard W. McMurray, John J. Armstrong, Paul W. Massie, Barry M. Califf, Robert M. O'Connor, Christopher M. Starling, Randall C. TI Baseline Cystatin C is Associated with Short-Term Adverse Events in Acute Heart Failure but Does Not Predict Treatment Effects with Nesiritide Therapy SO CIRCULATION LA English DT Meeting Abstract CT Scientific Sessions of the American-Heart-Association/Resuscitation Science Symposium CY NOV 12-16, 2011 CL Orlando, FL SP Amer Heart Assoc DE Renal function C1 [Tang, W. H. Wilson; Hsu, Amy P.; Starling, Randall C.] Cleveland Clin, Cleveland, OH 44106 USA. [Felker, G. Michael; Hernandez, Adrian F.; O'Connor, Christopher M.] Duke Univ, Med Ctr, Duke Clin Rsch Inst, Durham, NC USA. [Gottlieb, Stephen S.] Univ Maryland, Baltimore, MD 21201 USA. [Voors, Adriaan A.] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands. [Butler, Javed] Emory Univ, Atlanta, GA 30322 USA. [Metra, Marco] Univ Brescia, Brescia, Italy. [Anker, Stefan D.] Appl Cachexia Rsch, Dept Cardiol, Berlin, Germany. [Troughton, Richard W.] Univ Otago, Christchurch, New Zealand. [McMurray, John J.] Univ Glasgow, Glasgow, Lanark, Scotland. [Armstrong, Paul W.] Univ Alberta, Edmonton, AB, Canada. [Massie, Barry M.] Univ Calif San Francisco, San Francisco VA Med Ctr, San Francisco, CA 94143 USA. [Califf, Robert M.] Duke Univ, Med Ctr, Duke Translat Med Inst, Durham, NC USA. RI Tang, Wai Hong/I-1238-2013 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13339 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705119 ER PT J AU Tawakol, A Fayad, ZA Mogg, R Alon, A Subramanian, S Abdelbaky, A Nunes, I Herman, G Beals, C Shankar, SS AF Tawakol, Ahmed Fayad, Zahi A. Mogg, Robin Alon, Achilles Subramanian, Sharath Abdelbaky, Amr Nunes, Irene Herman, Gary Beals, Chan Shankar, Sudha S. TI High Dose Statin Results in a Further Reduction in Atherosclerotic Inflammation Compared with Low Dose Statin: Results of a Multi-Center PET-CT Study SO CIRCULATION LA English DT Meeting Abstract DE Positron emission tomography; Arteriosclerosis; Statins; Inflammation C1 [Tawakol, Ahmed; Subramanian, Sharath; Abdelbaky, Amr] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Fayad, Zahi A.] Mt Sainai Hosp, New York, NY USA. [Mogg, Robin; Alon, Achilles; Nunes, Irene; Herman, Gary; Beals, Chan; Shankar, Sudha S.] Merck, Expt Med, Rahway, NJ USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A18242 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738709127 ER PT J AU Thirunavukkarasu, M Oriowo, B Zhan, LJ Maulik, G Takeda, K Fong, GH Sanchez, JA Maulik, N AF Thirunavukkarasu, Mahesh Oriowo, Babatunde Zhan, Lijun Maulik, Gautam Takeda, Kotaro Fong, Guo-Hua Sanchez, Juan A. Maulik, Nilanjana TI Silencing Prolyl Hydroxylase-1(phd-1) Induces Neovascularization, Reduces Ventricular Remodeling by Stabilization and Activation of Hif-1 Alpha, Nf-Kappab/Hspa12b in the Infarcted Myocardium: A Study With Phd-1 Knockout Mice SO CIRCULATION LA English DT Meeting Abstract DE Infarction; Growth factors; Stress; Angiogenesis; Signal transduction C1 [Thirunavukkarasu, Mahesh; Oriowo, Babatunde; Zhan, Lijun; Takeda, Kotaro; Fong, Guo-Hua; Maulik, Nilanjana] Univ Connecticut, Sch Med, Farmington, CT USA. [Maulik, Gautam] Dana Farber Canc Inst, Boston, MA 02115 USA. [Sanchez, Juan A.] St Marys Hosp, Waterbury, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15905 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707229 ER PT J AU Ton, K Watts, J Malhotra, R Sanchorawala, V Seldin, D Borase, M Semigran, M AF Ton, Khue Watts, James Malhotra, Rajeev Sanchorawala, Vaishali Seldin, David Borase, Megan Semigran, Marc TI Predictors of Survival to Orthotopic Heart Transplant in Patients with Immunoglobulin Light Chain Amyloid Cardiomyopathy SO CIRCULATION LA English DT Meeting Abstract DE Heart failure; Ampk C1 [Ton, Khue; Watts, James; Malhotra, Rajeev; Borase, Megan; Semigran, Marc] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Sanchorawala, Vaishali; Seldin, David] Boston Med Cntr, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A18160 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738709109 ER PT J AU Tricoci, P Leonardi, S White, JA Tinga, B Giugliano, RP White, HD Armstrong, PW Kleiman, NS Sulimov, VA Tanguay, JF Lewis, BS James, SK Gibson, CM Braunwald, E Van de Werf, F Califf, RM Mahaffey, KW Newby, LK AF Tricoci, Pierluigi Leonardi, Sergio White, Jennifer A. Tinga, Brian Giugliano, Robert P. White, Harvey D. Armstrong, Paul W. Kleiman, Neal S. Sulimov, Vitaly A. Tanguay, Jean-Francois Lewis, Basil S. James, Stefan K. Gibson, C. M. Braunwald, Eugene Van de Werf, Frans Califf, Robert M. Mahaffey, Kenneth W. Newby, L. K. TI Re-Elevation of Troponin Following Percutaneous Coronary Intervention Significantly Predicts 1-Year Mortality in Patients with High-risk Non-ST-Segment Elevation Acute Coronary Syndromes SO CIRCULATION LA English DT Meeting Abstract DE Troponin; Percutaneous coronary intervention; Acute coronary syndromes; Prognosis C1 [Tricoci, Pierluigi; Leonardi, Sergio; White, Jennifer A.; Tinga, Brian; Gibson, C. M.; Califf, Robert M.; Mahaffey, Kenneth W.; Newby, L. K.] Duke Univ Med Cntr, Duke Clin Rsch Inst, Durham, NC USA. [Giugliano, Robert P.; Braunwald, Eugene] Brigham & Womens Hosp, TIMI Study Grp, Boston, MA 02115 USA. [White, Harvey D.] Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand. [Armstrong, Paul W.] Univ Alberta, Canadian VIGOUR Cntr, Edmonton, AB, Canada. [Kleiman, Neal S.] Methodist Hosp, Methodist DeBakey Heart & Vasc Cntr, Houston, TX 77030 USA. [Sulimov, Vitaly A.] First Moscow State Med Univ, Dept Internal Dis, Moscow, Russia. [Tanguay, Jean-Francois] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada. [Lewis, Basil S.] Technion Israel Inst Technol, Haifa, Israel. [James, Stefan K.] Univ Uppsala Hosp, Uppsala, Sweden. [Van de Werf, Frans] Gasthuisberg Univ Hosps Leuven, Dept Cardiovasc Dis, Louvain, Belgium. NR 0 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9150 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701278 ER PT J AU Tsai, TT Maddox, TM Nallamothu, BK Stanislawski, MA Adams, JC Box, TL Ho, PM Rao, SV Casserly, IP Rumsfeld, JS Brilakis, ES AF Tsai, Thomas T. Maddox, Thomas M. Nallamothu, Brahmajee K. Stanislawski, Maggie A. Adams, Jill C. Box, Tamara L. Ho, P. Michael Rao, Sunil V. Casserly, Ivan P. Rumsfeld, John S. Brilakis, Emmanouil S. TI Use and Effectiveness of Drug-Eluting versus Bare Metal Stents in Saphenous Vein Bypass Graft Percutaneous Coronary Interventions: Insights from the National VA Clinical Assessment, Reporting and Tracking (CART) Program SO CIRCULATION LA English DT Meeting Abstract DE Percutaneous coronary intervention; Interventional cardiology; Drug eluting stents C1 [Tsai, Thomas T.; Maddox, Thomas M.; Stanislawski, Maggie A.; Adams, Jill C.; Box, Tamara L.; Ho, P. Michael; Casserly, Ivan P.; Rumsfeld, John S.] Denver VAMC, Denver, CO USA. [Nallamothu, Brahmajee K.] Ann Arbor VAMC, Ann Arbor, MI USA. [Rao, Sunil V.] Durham VA Med Cntr, Durham, NC USA. [Brilakis, Emmanouil S.] VA N Texas Hlth Care Syst, Dallas, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A17341 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708367 ER PT J AU Tsai, TT Dattilo, PB Warner, J Donaldson, D Virchow, A Stanislawski, MA O'Donnell, CI Rogers, RK Shunk, KA Jones, WS Kinlay, S Brilakis, ES Klein, AP Casserly, IP Rumsfeld, JS AF Tsai, Thomas T. Dattilo, Philip B. Warner, Jeremy Donaldson, Darcy Virchow, Allison Stanislawski, Maggie A. O'Donnell, Colin I. Rogers, R. Kevin Shunk, Kendrick A. Jones, William S. Kinlay, Scott Brilakis, Emmanouil S. Klein, Andrew P. Casserly, Ivan P. Rumsfeld, John S. TI Contemporary Treatment and Outcomes of Peripheral Vascular Interventions for Symptomatic Lower Extremity Peripheral Arterial Disease: Insights From the National VA Clinical Assessment, Reporting and Tracking (VA-CART) Program Peripheral Registry SO CIRCULATION LA English DT Meeting Abstract DE Peripheral arterial disease; Vascular disease C1 [Dattilo, Philip B.] Univ Colorado, Denver VAMC, Denver, CO USA. [Shunk, Kendrick A.] San Francisco VA Med Ctr, Internal Med Cardiol, San Francisco, CA USA. [Jones, William S.] Durham VA Med Cntr, Durham, NC USA. [Kinlay, Scott] VA Boston Healthcare Syst, Internal Med Cardiol, Boston, MA USA. [Brilakis, Emmanouil S.] VA N Texas Hlth Care Syst, Internal Med Cardiol, Dallas, TX USA. [Klein, Andrew P.] St Louis VA Med Cntr, St Louis, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A16711 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738708129 ER PT J AU Tsai, TT Maddox, TM Bradley, SM Gylys-Colwell, I McDermott, K Helfrich, CD Fihn, SD Bryson, CL Rumsfeld, JS Ho, PM AF Tsai, Thomas T. Maddox, Thomas M. Bradley, Steven M. Gylys-Colwell, Ina McDermott, Kelly Helfrich, Christian D. Fihn, Stephan D. Bryson, Christopher L. Rumsfeld, John S. Ho, P. Michael TI Long-Term Risk of Bleeding and Impact of Non-Therapeutic INRs in Patients Discharged on Triple Antithrombotic Therapy After Hospitalization For Acute Coronary Syndrome SO CIRCULATION LA English DT Meeting Abstract DE Acute coronary syndromes; Anticoagulants; Antiplatelet drugs C1 [Tsai, Thomas T.; Maddox, Thomas M.; Rumsfeld, John S.; Ho, P. Michael] Denver VAMC, Denver, CO USA. [Bradley, Steven M.] VA Puget Sound Hlth Care Syst, Internal Med Cardiol, Seattle, WA USA. [Gylys-Colwell, Ina; McDermott, Kelly; Helfrich, Christian D.; Fihn, Stephan D.; Bryson, Christopher L.] VA Puget Sound Hlth Care Syst, Internal Med, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A14336 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738706085 ER PT J AU Udell, JA Steg, PG Scirica, BM Smith, SC Ohman, EM Eagle, KA Goto, S Cho, JI Bhatt, DL AF Udell, Jacob A. Steg, Ph. G. Scirica, Benjamin M. Smith, Sidney C., Jr. Ohman, E. M. Eagle, Kim A. Goto, Shinya Cho, Jang Ik Bhatt, Deepak L. CA REACH Registry Investigators TI Living Alone and Cardiovascular Events in Stable Outpatients at Risk of or with Atherothrombosis: Insight From the REACH Registry SO CIRCULATION LA English DT Meeting Abstract DE Cardiovascular disease; Epidemiology; Longitudinal studies; Lifestyle; Risk factors C1 [Udell, Jacob A.; Scirica, Benjamin M.; Cho, Jang Ik] Brigham & Womens Hosp, Boston, MA 02115 USA. [Steg, Ph. G.] Univ Paris Diderot, Dept Cardiol, INSERM, U698, Paris, France. [Steg, Ph. G.] AP HP, Paris, France. [Smith, Sidney C., Jr.] Univ N Carolina, Cntr Cardiovasc Sci & Med, Chapel Hill, NC USA. [Ohman, E. M.] Duke Clin Rsch Inst, Durham, NC USA. [Eagle, Kim A.] Univ Michigan Hlth Syst, Ann Arbor, MI USA. [Goto, Shinya] Tokai Univ, Sch Med, Dept Med, Isehara, Kanagawa 25911, Japan. [Bhatt, Deepak L.] VA Boston Healthcare Syst, Cardiovasc Med, W Roxbury, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A9328 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738701347 ER PT J AU Venkitachalam, L Spertus, JA Kennedy, KF Amin, AP Stolker, JM Yeh, RW Normand, SLT Kleiman, NS Cohen, DJ AF Venkitachalam, Lakshmi Spertus, John A. Kennedy, Kevin F. Amin, Amit P. Stolker, Joshua M. Yeh, Robert W. Normand, Sharon-Lise T. Kleiman, Neal S. Cohen, David J. TI Optimal Use of Drug-Eluting Stents in PCI: Implications of Healthcare Policy in Real-World Practice SO CIRCULATION LA English DT Meeting Abstract DE Drug eluting stents; Percutaneous coronary intervention; Health policy; Effectiveness C1 [Venkitachalam, Lakshmi; Spertus, John A.; Kennedy, Kevin F.; Amin, Amit P.; Cohen, David J.] St Lukes Mid Amer Heart & Vasc Inst, CV Outcomes Rsch, Kansas City, MO USA. [Stolker, Joshua M.] St Louis Univ, CV Outcomes Rsch, St Louis, MO 63103 USA. [Yeh, Robert W.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol,Dept Med, Boston, MA USA. [Normand, Sharon-Lise T.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Normand, Sharon-Lise T.] Harvard Univ, Sch Publ Hlth, Dept Healthcare Policy, Boston, MA 02115 USA. [Kleiman, Neal S.] Methodist Debakey Heart Cntr, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A14469 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738706127 ER PT J AU Waks, JW Sabatine, MS Cannon, CP Morrow, DA Gibson, CM Wiviott, SD Giugliano, RP Sloan, S Braunwald, E Scirica, BM AF Waks, Jonathan W. Sabatine, Marc S. Cannon, Christopher P. Morrow, David A. Gibson, C. M. Wiviott, Stephen D. Giugliano, Robert P. Sloan, Sarah Braunwald, Eugene Scirica, Benjamin M. TI Improved Risk Stratification in Patients with ST-Elevation Myocardial Infarction Treated with Fibrinolysis by Combining New Q-Waves on the Initial Electrocardiogram with ST-Segment Resolution-Observations from the CLARITY-TIMI 28 Trial SO CIRCULATION LA English DT Meeting Abstract DE STEMI; Acute coronary syndromes; Prognosis; Clopidogrel; ST segments C1 [Waks, Jonathan W.; Sabatine, Marc S.; Cannon, Christopher P.; Morrow, David A.; Wiviott, Stephen D.; Giugliano, Robert P.; Sloan, Sarah; Braunwald, Eugene; Scirica, Benjamin M.] Brigham & Womens Hosp, Dept Med, TIMI Study Grp, Boston, MA 02115 USA. [Gibson, C. M.] Beth Isreal Deaconess Hosp, Dept Med, TIMI Study Grp, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A11302 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738703194 ER PT J AU Weiner, R Kim, J Wang, FL Wood, MJ Wang, TJ Hutter, AM Picard, MH Baggish, AL AF Weiner, Rory Kim, Jonathan Wang, Francis L. Wood, Malissa J. Wang, Thomas J. Hutter, Adolph M. Picard, Michael H. Baggish, Aaron L. TI Endurance Exercise Training Impairs the Myocardial Response to Acute Pressure Challenge SO CIRCULATION LA English DT Meeting Abstract DE Hypertrophy; Myocardial torsion and recoil; Pressure - volume relation; Ventricular function C1 [Weiner, Rory; Kim, Jonathan; Wood, Malissa J.; Wang, Thomas J.; Hutter, Adolph M.; Picard, Michael H.; Baggish, Aaron L.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Wang, Francis L.] Harvard Univ Hlth Serv, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15384 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707049 ER PT J AU Xian, Y Fonarow, GC Reeves, MJ Webb, LE Blevins, J Demyanenko, VS Olson, DM Hernandez, AF Peterson, ED Schwamm, LH Smith, EE AF Xian, Ying Fonarow, Gregg C. Reeves, Mathew J. Webb, Laura E. Blevins, Jason Demyanenko, Vladimir S. Olson, DaiWai M. Hernandez, Adrian F. Peterson, Eric D. Schwamm, Lee H. Smith, Eric E. TI Data Quality in the American Heart Association Get With the Guidelines-Stroke: Results from a National Data Validation Audit SO CIRCULATION LA English DT Meeting Abstract DE Outcomes; Stroke; Quality improvement C1 [Xian, Ying; Webb, Laura E.; Blevins, Jason; Demyanenko, Vladimir S.; Olson, DaiWai M.; Hernandez, Adrian F.; Peterson, Eric D.] Duke Clin Rsch Inst, Durham, NC USA. [Fonarow, Gregg C.] Univ Calif Los Angeles, Div Cardiol, Los Angeles, CA USA. [Reeves, Mathew J.] Michigan State Univ, Dept Epidemiol, E Lansing, MI 48824 USA. [Schwamm, Lee H.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Smith, Eric E.] Univ Calgary, Dept Clin Neurosci, Hotchkiss Brain Inst, Calgary, AB, Canada. RI Smith, Eric/C-5443-2012 OI Smith, Eric/0000-0003-3956-1668 NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA 13246 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705095 ER PT J AU Zeng, X Zou, L Levine, RA Guerrero, JL Handschumacher, MD Sullivan, S Solis, J Berlin, J Braithwaite, GJ Muratoglu, OK Vlahakes, GJ Hung, J AF Zeng, Xin Zou, Lin Levine, Robert A. Guerrero, J. Luis Handschumacher, Mark D. Sullivan, Suzanne Solis, Jorge Berlin, Jason Braithwaite, Gavin J. Muratoglu, Orhun K. Vlahakes, Gus J. Hung, Judy TI Chronic Polymer Injection to Reduce Ischemic MR: Stabilizes the Mitral Valve-Ventricular Spatial Relationship SO CIRCULATION LA English DT Meeting Abstract DE Mitral regurgitation; Myocardial infarction; Remodeling; Echocardiography C1 [Zeng, Xin; Zou, Lin; Levine, Robert A.; Handschumacher, Mark D.; Solis, Jorge; Hung, Judy] Massachusetts Gen Hosp, Cardiac Ultrasound Lab, Boston, MA 02114 USA. [Guerrero, J. Luis; Sullivan, Suzanne; Vlahakes, Gus J.] Massachusetts Gen Hosp, Div Cardiac Surg, Boston, MA 02114 USA. [Berlin, Jason] Cambridge Polymer Inc, Boston, MA USA. [Braithwaite, Gavin J.] Cambridge Polymer Grp Inc, Boston, MA USA. [Muratoglu, Orhun K.] Massachusetts Gen Hosp, Dept Orthoped Surg, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12795 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704313 ER PT J AU Zou, L Zeng, X Solis, J Handschumacher, MD Guerrero, JL Sullivan, SM Palmeri, NO Chaput, M Levine, RA Hung, J AF Zou, Lin Zeng, Xin Solis, Jorge Handschumacher, Mark D. Guerrero, J. Luis Sullivan, Suzanne M. Palmeri, Nicholoas O. Chaput, Miguel Levine, Robert A. Hung, Judy TI Adequate Mitral Leaflet Compensation Prevents Development of Ischemic Mitral Regurgitation SO CIRCULATION LA English DT Meeting Abstract DE Mitral regurgitation; Echocardiography; Cardiac imaging C1 [Zou, Lin; Zeng, Xin; Solis, Jorge; Handschumacher, Mark D.; Sullivan, Suzanne M.; Palmeri, Nicholoas O.; Chaput, Miguel; Levine, Robert A.; Hung, Judy] Massachusetts Gen Hosp, Cardiac Ultrasound Lab, Boston, MA 02114 USA. [Guerrero, J. Luis] Massachusetts Gen Hosp, Cardiac Surg Lab, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15629 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707136 ER PT J AU Zou, YP Yu, H Ren, XF Hou, JB Zhang, SS Yu, B Jang, IK AF Zou, Yongpeng Yu, Huai Ren, Xuefeng Hou, Jingbo Zhang, Shaosong Yu, Bo Jang, Ik-Kyung TI Prevention of Stent Grafts Restenosis by Pretreatment with Sirolimus Eluting Stent (SES) SO CIRCULATION LA English DT Meeting Abstract DE Stent; Restenosis; Coronary heart disease; Angiocardiography C1 [Zou, Yongpeng; Yu, Huai; Ren, Xuefeng; Hou, Jingbo; Yu, Bo] Harbin Med Coll, Affiliated Hosp 2, Harbin, Peoples R China. [Zhang, Shaosong] St Jude Med, LightLab Imaging, Boston, MA USA. [Jang, Ik-Kyung] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A12401 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738704203 ER PT J AU Stienen, BMC de Gelde, B AF Stienen, Bernard M. C. de Gelde, Beatrice TI Fear modulates visual awareness similarly for facial and bodily expressions SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Article DE binocular rivalry; emotion; face; body; expression; consciousness ID HUMAN EXTRASTRIATE CORTEX; EMOTIONAL BODY LANGUAGE; BINOCULAR-RIVALRY; STRIATE CORTEX; HUMAN AMYGDALA; NEURAL BASES; FACES; ATTENTION; STIMULATION; RECOGNITION AB Background: Social interaction depends on a multitude of signals carrying information about the emotional state of others. But the relative importance of facial and bodily signals is still poorly understood. Past research has focused on the perception of facial expressions while perception of whole body signals has only been studied recently. In order to better understand the relative contribution of affective signals from the face only or from the whole body we performed two experiments using binocular rivalry. This method seems to be perfectly suitable to contrast two classes of stimuli to test our processing sensitivity to either stimulus and to address the question how emotion modulates this sensitivity. Method: In the first experiment we directly contrasted fearful, angry, and neutral bodies and faces. We always presented bodies in one eye and faces in the other simultaneously for 60s and asked participants to report what they perceived. In the second experiment we focused specifically on the role of fearful expressions of faces and bodies. Results: Taken together the two experiments show that there is no clear bias toward either the face or body when the expression of the body and face are neutral or angry. However, the perceptual dominance in favor of either the face of the body is a function of the stimulus class expressing fear. C1 [Stienen, Bernard M. C.; de Gelde, Beatrice] Tilburg Univ, Lab Cognit & Affect Neurosci, NL-5000 LE Tilburg, Netherlands. [de Gelde, Beatrice] Massachusetts Gen Hosp, Mart Ctr Biomed Imaging, Charlestown, MA USA. [de Gelde, Beatrice] Harvard Univ, Sch Med, Charlestown, MA USA. RP de Gelde, B (reprint author), Tilburg Univ, Lab Cognit & Affect Neurosci, NL-5000 LE Tilburg, Netherlands. EM B.deGelder@uvt.nl FU NWO; Tango; European Commission [249858]; EU [FDP6-NEST-043403] FX Beatrice de Gelder was funded by NWO and by Tango. The project Tango acknowledges the financial support of the Future and Emerging Technologies (FET) programme within the Seventh Framework Programme for Research of the European Commission, under FET-Open grant number: 249858. Bernard M. C. Stienen was funded by EU project COBOL (FDP6-NEST-043403). NR 42 TC 4 Z9 5 U1 2 U2 13 PU FRONTIERS RES FOUND PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD NOV 22 PY 2011 VL 5 AR 132 DI 10.3389/fnhum.2011.00132 PG 8 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA 882GD UT WOS:000299550900001 PM 22125517 ER PT J AU McCabe, JM Bhave, PD McGlothlin, D Teerlink, JR AF McCabe, James M. Bhave, Prashant D. McGlothlin, Dana Teerlink, John R. TI Running From Her Past A Case of Rapidly Progressive Dyspnea on Exertion SO CIRCULATION LA English DT Article DE microvascular obstruction; pulmonary hypertension; right ventricular failure; tumor; microangiopathy ID TUMOR THROMBOTIC MICROANGIOPATHY; PULMONARY-HYPERTENSION; DIAGNOSIS; CATHETER C1 [McCabe, James M.; Bhave, Prashant D.; McGlothlin, Dana; Teerlink, John R.] Univ Calif San Francisco, Div Cardiol, San Francisco, CA USA. [Teerlink, John R.] San Francisco VA Med Ctr, Cardiol Sect, San Francisco, CA USA. RP McCabe, JM (reprint author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiol, 75 Francis St, Boston, MA 02115 USA. EM mccabe@aya.yale.edu RI Teerlink, John/D-2986-2012 NR 13 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 BP 2355 EP 2361 DI 10.1161/CIRCULATIONAHA.111.045906 PG 7 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 852BR UT WOS:000297320900020 PM 22105198 ER PT J AU Giugliano, RP Braunwald, E AF Giugliano, Robert P. Braunwald, Eugene TI The Year in Non-ST-Segment Elevation Acute Coronary Syndrome SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article DE acute coronary syndrome(s); myocardial infarction; unstable angina ID CARDIOVASCULAR RISK PREDICTION; OPTICAL COHERENCE TOMOGRAPHY; ACUTE MYOCARDIAL-INFARCTION; UNSTABLE ANGINA-PECTORIS; BARE-METAL STENTS; TRITON-TIMI 38; ANTIPLATELET THERAPY; PLATELET INHIBITION; RANDOMIZED-TRIAL; PROGNOSTIC VALUE C1 [Giugliano, Robert P.; Braunwald, Eugene] Harvard Univ, Sch Med, TIMI Study Grp, Div Cardiovasc Med,Brigham & Womens Hosp, Boston, MA 02115 USA. RP Braunwald, E (reprint author), Harvard Univ, Sch Med, TIMI Study Grp, Div Cardiovasc Med,Brigham & Womens Hosp, 350 Longwood Ave, Boston, MA 02115 USA. EM ebraunwald@partners.org FU AstraZeneca; Bayer; Bristol-Myers Squibb; Beckman Coulter; Daiichi Sankyo; Eli Lilly; GlaxoSmithKline; Genentech; Integrated Therapeutics; Johnson Johnson; Merck; Roche Diagnostics; Sanofi-Aventis; Amgen; Regeneron FX From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Dr. Giugliano has received research grant support and/or honoraria for consulting/CME lectures from Amgen, Daiichi Sankyo, Merck, Regeneron, and Sanofi-Aventis. Dr. Braunwald has received research grant support from AstraZeneca, Bayer, Bristol-Myers Squibb, Beckman Coulter, Daiichi Sankyo, Eli Lilly, GlaxoSmithKline, Genentech, Integrated Therapeutics, Johnson & Johnson, Merck, Roche Diagnostics, and Sanofi-Aventis; and consults for or serves on the advisory board of Amorcyte, CardioRentis, Daiichi Sankyo, Eli Lilly, Genzyme, The Medicines Co., and Merck. NR 101 TC 5 Z9 6 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD NOV 22 PY 2011 VL 58 IS 22 BP 2342 EP 2354 DI 10.1016/j.jacc.2011.08.042 PG 13 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 849UD UT WOS:000297149900015 PM 22093514 ER PT J AU Vandenwijngaert, S Pokreisz, P Gillijns, H Hermans, H Swinnen, M Dresselaers, T Balogh, A Papp, Z Herijgers, P D'hooge, J Bartunek, J Bloch, KD Janssens, S AF Vandenwijngaert, Sara Pokreisz, Peter Gillijns, Hilde Hermans, Hadewich Swinnen, Melissa Dresselaers, Tom Balogh, Agnes Papp, Zoltan Herijgers, Paul D'hooge, Jan Bartunek, Jozef Bloch, Kenneth D. Janssens, Stefan TI Myocardial Phosphodiesterase 5 is Increased in Patients With Severe Aortic Stenosis and Contributes to Left Ventricular Dysfunction in Pressure-Overloaded Mice SO CIRCULATION LA English DT Meeting Abstract CT American-Heart-Association Resuscitation Science Symposium CY NOV 12-16, 2011 CL Orlando, FL SP Amer Heart Assoc (AHA) DE Ventricular remodeling; Aortic stenosis; Signal transduction; Cardiac hypertrophy; Heart failure C1 [Vandenwijngaert, Sara; Pokreisz, Peter; Gillijns, Hilde; Hermans, Hadewich; Swinnen, Melissa; Herijgers, Paul; D'hooge, Jan; Janssens, Stefan] Katholieke Univ Leuven, Dept Cardiovasc Dis, Louvain, Belgium. [Dresselaers, Tom] Katholieke Univ Leuven, Dept Med Diagnost Sci, Louvain, Belgium. [Balogh, Agnes; Papp, Zoltan] Univ Debrecen, Div Clin Physiol, Inst Cardiol, H-4012 Debrecen, Hungary. [Bartunek, Jozef] Onze Lieve Vrouw Hosp, Cardiovas Cntr Aalst, Aalst, Belgium. [Bloch, Kenneth D.] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA. [Bloch, Kenneth D.] Harvard Univ, Sch Med, Boston, MA USA. RI Herijgers, Paul/B-8064-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15839 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707206 ER PT J AU Ono, J Yaeger, KA Genevay, M Mino-Kenudson, M Brugge, WR Pitman, MB AF Ono, Jill Yaeger, Kurt A. Genevay, Muriel Mino-Kenudson, Mari Brugge, William R. Pitman, Martha B. TI Cytological analysis of small branch-duct intraductal papillary mucinous neoplasms provides a more accurate risk assessment of malignancy than symptoms SO CYTOJOURNAL LA English DT Article DE Branch-duct; cytology; fine needle aspiration biopsy; intraductal papillary mucinous neoplasm; pancreas; Sendai guidelines; symptoms ID INCIDENTAL PANCREATIC CYSTS; CLINICOPATHOLOGICAL CHARACTERISTICS; UPDATED EXPERIENCE; MANAGEMENT; PREDICTORS; RESECTION; GUIDELINES; DIAGNOSIS; LESIONS; GRADE AB Objectives: The Sendai guidelines for management of patients with clinically suspected intraductal papillary mucinous neoplasms (IPMN) recommend resection of cysts > 30 mm, a dilated main pancreatic duct (MPD) > 6 mm, a mural nodule (MN), symptoms or positive cytology. Although sensitive, asymptomatic cysts, nonspecific symptoms, and a high threshold for positive cytology limit the specificity of the guidelines. We have assessed the value of cytology relative to symptom for predicting malignancy in IPMNs without high-risk imaging features. Materials and Methods: We retrospectively reviewed the clinical, radiological, and cytological data of 31 small branch-duct IPMNs without a MN. The cytological presence of high-grade atypical epithelial cells (HGA) was considered true positive, with a corresponding histology of high-grade dysplasia or invasive carcinoma. The performance of cytology versus symptoms was evaluated by calculating the sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy. Results: The sensitivity (0.80), specificity (0.85), and accuracy (0.84) of HGA were higher than the corresponding performance characteristics of symptoms (0.60, 0.45, and 0.48, respectively). The NPV of no HGA on cytology was > 95. Conclusions: Cytology is a better predictor of malignancy than symptoms, for the conservative management of small branch-duct IPMNs. Cytology contributes to a highly accurate triple negative test for malignancy in small IPMN: No dilated MPD, MN or HGA. C1 [Ono, Jill; Yaeger, Kurt A.; Mino-Kenudson, Mari; Pitman, Martha B.] Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Brugge, William R.] Harvard Univ, Sch Med, Dept Med, Massachusetts Gen Hosp,Div Gastroenterol, Boston, MA 02115 USA. [Genevay, Muriel] Univ Hosp Geneva, Serv Clin Pathol, Geneva, Switzerland. RP Pitman, MB (reprint author), Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA. EM jillcono@yahoo.com; kurtyaegs@msn.com; muriel.Genevay@hcuge.ch; mminokenudson@partners.org; wbrugge@partners.org; mpitman@partners.org NR 36 TC 18 Z9 18 U1 0 U2 0 PU MEDKNOW PUBLICATIONS PI MUMBAI PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA SN 0974-5963 J9 CYTOJOURNAL JI CytoJournal PD NOV 21 PY 2011 VL 8 AR 21 DI 10.4103/1742-6413.90084 PG 5 WC Pathology SC Pathology GA 976BL UT WOS:000306555400002 PM 22145009 ER PT J AU Wernimont, SM Clark, AG Stover, PJ Wells, MT Litonjua, AA Weiss, ST Gaziano, JM Tucker, KL Baccarelli, A Schwartz, J Bollati, V Cassano, PA AF Wernimont, Susan M. Clark, Andrew G. Stover, Patrick J. Wells, Martin T. Litonjua, Augusto A. Weiss, Scott T. Gaziano, J. Michael Tucker, Katherine L. Baccarelli, Andrea Schwartz, Joel Bollati, Valentina Cassano, Patricia A. TI Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study SO BMC MEDICAL GENETICS LA English DT Article ID ONE-CARBON METABOLISM; CORONARY-HEART-DISEASE; DNA METHYLATION; S-ADENOSYLHOMOCYSTEINE; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE; METAANALYSIS; POLYMORPHISMS; VETERANS; MTHFR AB Background: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease. Methods: 330 SNPs in 52 genes were studied in relation to plasma homocysteine and global genomic DNA methylation. SNPs were selected based on functional effects and gene coverage, and assays were completed on the Illumina Goldengate platform. Age-, smoking-, and nutrient-adjusted genotype-phenotype associations were estimated in regression models. Results: Using a nominal P <= 0.005 threshold for statistical significance, 20 SNPs were associated with plasma homocysteine, 8 with Alu methylation, and 1 with LINE-1 methylation. Using a more stringent false discovery rate threshold, SNPs in FTCD, SLC19A1, and SLC19A3 genes remained associated with plasma homocysteine. Gene by vitamin B-6 interactions were identified for both Alu and LINE-1 methylation, and epistatic interactions with the MTHFR rs1801133 SNP were identified for the plasma homocysteine phenotype. Pleiotropy involving the MTHFD1L and SARDH genes for both plasma homocysteine and Alu methylation phenotypes was identified. Conclusions: No single gene was associated with all three phenotypes, and the set of the most statistically significant SNPs predictive of homocysteine or Alu or LINE-1 methylation was unique to each phenotype. Genetic variation in folate-mediated one-carbon metabolism, other than the well-known effects of the MTHFR c.665C > T (known as c.677 C > T, rs1801133, p.Ala222Val), is predictive of cardiovascular disease biomarkers. C1 [Wernimont, Susan M.; Stover, Patrick J.; Cassano, Patricia A.] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA. [Clark, Andrew G.] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA. [Wells, Martin T.] Cornell, Dept Biol Stat & Computat Biol, Ithaca, NY USA. [Litonjua, Augusto A.; Weiss, Scott T.] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA. [Litonjua, Augusto A.; Weiss, Scott T.] Harvard Univ, Sch Med, Boston, MA USA. [Gaziano, J. Michael] VA Boston Healthcare Syst, Vet Adm VA Normat Aging Study, Boston, MA USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Div Aging, Boston, MA 02115 USA. [Tucker, Katherine L.] Northeastern Univ, Dept Hlth Sci, Boston, MA 02115 USA. [Baccarelli, Andrea; Schwartz, Joel] Harvard Univ, Dept Environm Hlth, Boston, MA 02115 USA. [Baccarelli, Andrea; Schwartz, Joel] Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA. [Baccarelli, Andrea; Bollati, Valentina] Univ Milan, Dept Environm & Occupat Hlth, Ctr Mol & Genet Epidemiol, Milan, Italy. [Baccarelli, Andrea; Bollati, Valentina] IRCCS Fdn Ca Granda Osped Maggiore Policlin, Milan, Italy. RP Cassano, PA (reprint author), Cornell Univ, Div Nutr Sci, 209 Savage Hall, Ithaca, NY 14853 USA. EM pac6@cornell.edu OI Baccarelli, Andrea/0000-0002-3436-0640; Litonjua, Augusto/0000-0003-0422-5875; Tucker, Katherine/0000-0001-7640-662X; Bollati, Valentina/0000-0002-0370-9598 FU Center for Vertebrate Genomics (PAC) at Cornell University; Presidents Council for Cornell Women (PAC) at Cornell University; Bronfenbrenner Life Course Center (PAC) at Cornell University; U.S. Department of Agriculture Cooperative State Research, Education, and Extension Service [2003-34324-13135]; Department of Veterans Affairs/ERIC; Massachusetts Veterans Epidemiology and Information Center (MAVERIC); National Institute of Environmental Health Sciences [ES014663, R01ES015172]; National Institute of Diabetes, Digestive and Kidney Diseases [T32DK007158]; Harvard School of Public Health-National Institute of Environmental Health Sciences Center for Environmental Health [ES000002]; National Heart, Lung, and Blood Institute [N01-HV-48195] FX The authors wish to thank Ms. Ellen M. Smith, Cornell '09, for her contributions to preliminary analyses for this work. The project was supported in part by the Center for Vertebrate Genomics (PAC), the Presidents Council for Cornell Women (PAC), and the Bronfenbrenner Life Course Center (PAC), all at Cornell University; by U.S. Department of Agriculture Cooperative State Research, Education, and Extension Service grant 2003-34324-13135 (subproject to PAC); The Veterans Administration (VA) Normative Aging Study is supported by the Department of Veterans Affairs Cooperative Studies Program/ERIC and is a research component of the Massachusetts Veterans Epidemiology and Information Center (MAVERIC); by National Institute of Environmental Health Sciences grant ES014663 (JS); and by T32DK007158 (SMW), National Institute of Diabetes, Digestive and Kidney Diseases. Dr. Baccarelli receives salary support from New Investigator funding from the Harvard School of Public Health-National Institute of Environmental Health Sciences Center for Environmental Health (ES000002). Dr. Schwartz receives support through National Institute of Environmental Health Sciences grant R01ES015172. Genotyping services were provided (to PAC) by the Johns Hopkins University under federal contract number (N01-HV-48195) from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes And Digestive And Kidney Diseases, the National Heart, Lung, and Blood Institute, or the National Institutes of Health. The funding bodies played no role in study design, the collection, analysis, and interpretation of data, the writing of the manuscript, or in the decision to submit the manuscript for publication. NR 44 TC 11 Z9 12 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2350 J9 BMC MED GENET JI BMC Med. Genet. PD NOV 21 PY 2011 VL 12 AR 150 DI 10.1186/1471-2350-12-150 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA 890PR UT WOS:000300157300001 PM 22103680 ER PT J AU Sinha, AU Merrill, E Armstrong, SA Clark, TW Das, S AF Sinha, Amit U. Merrill, Emily Armstrong, Scott A. Clark, Tim W. Das, Sudeshna TI eXframe: reusable framework for storage, analysis and visualization of genomics experiments SO BMC BIOINFORMATICS LA English DT Article ID MODEL-BASED ANALYSIS; MICROARRAY DATABASE; GENE-EXPRESSION; RNA-SEQ; INFORMATION; REPOSITORY; STANDARDS; MOLGENIS; PLATFORM AB Background: Genome-wide experiments are routinely conducted to measure gene expression, DNA-protein interactions and epigenetic status. Structured metadata for these experiments is imperative for a complete understanding of experimental conditions, to enable consistent data processing and to allow retrieval, comparison, and integration of experimental results. Even though several repositories have been developed for genomics data, only a few provide annotation of samples and assays using controlled vocabularies. Moreover, many of them are tailored for a single type of technology or measurement and do not support the integration of multiple data types. Results: We have developed eXframe - a reusable web-based framework for genomics experiments that provides 1) the ability to publish structured data compliant with accepted standards 2) support for multiple data types including microarrays and next generation sequencing 3) query, analysis and visualization integration tools (enabled by consistent processing of the raw data and annotation of samples) and is available as open-source software. We present two case studies where this software is currently being used to build repositories of genomics experiments - one contains data from hematopoietic stem cells and another from Parkinson's disease patients. Conclusion: The web-based framework eXframe offers structured annotation of experiments as well as uniform processing and storage of molecular data from microarray and next generation sequencing platforms. The framework allows users to query and integrate information across species, technologies, measurement types and experimental conditions. Our framework is reusable and freely modifiable - other groups or institutions can deploy their own custom web-based repositories based on this software. It is interoperable with the most important data formats in this domain. We hope that other groups will not only use eXframe, but also contribute their own useful modifications. C1 [Merrill, Emily; Clark, Tim W.; Das, Sudeshna] Massachusetts Gen Hosp, MassGen Inst Neurodegenerat Dis, Cambridge, MA 02139 USA. [Sinha, Amit U.; Armstrong, Scott A.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Clark, Tim W.; Das, Sudeshna] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA. RP Das, S (reprint author), Massachusetts Gen Hosp, MassGen Inst Neurodegenerat Dis, Cambridge, MA 02139 USA. EM sudeshna_das@harvard.edu OI Clark, Timothy/0000-0003-4060-7360 FU Harvard Stem Cell Institute (HSCI) FX We would like to acknowledge the Harvard Stem Cell Institute (HSCI) for funding and support. We thank Dr. Daniel Tenen, Dr. David Scadden, Dr. Len Zon, Dr. Stuart Orkin and Dr. Clemens Scherzer for helpful discussions and for providing requirements. Lastly, we thank Siavash Safarizadeh of We Web Workers (http://www.wewebworkers.com/) for all his contributions to Drupal programming. NR 29 TC 2 Z9 2 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD NOV 21 PY 2011 VL 12 AR 452 DI 10.1186/1471-2105-12-452 PG 13 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 861FW UT WOS:000298005800001 PM 22103807 ER PT J AU Kuranov, RV Kazmi, S McElroy, AB Kiel, JW Dunn, AK Milner, TE Duong, TQ AF Kuranov, Roman V. Kazmi, Shams McElroy, Austin B. Kiel, Jeffrey W. Dunn, Andrew K. Milner, Thomas E. Duong, Timothy Q. TI In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT SO OPTICS EXPRESS LA English DT Article ID OPTICAL COHERENCE TOMOGRAPHY; RETINAL OXYGENATION; BLOOD-FLOW; TISSUE; RAT; RESOLUTION; TENSION; BRAIN; PHOSPHORESCENCE; ERYTHROCYTES AB Microvasculature hemoglobin oxygen saturation (SaO(2)) is important in the progression of various pathologies. Non-invasive depth-resolved measurement of SaO(2) levels in tissue microvasculature has the potential to provide early biomarkers and a better understanding of the pathophysiological processes allowing improved diagnostics and prediction of disease progression. We report proof-of-concept in vivo depth-resolved measurement of SaO(2) levels in selected 30 mu m diameter arterioles in the murine brain using Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) with 800 nm and 770 nm photothermal excitation wavelengths. Depth location of back-reflected light from a target arteriole was confirmed using Doppler and speckle contrast OCT images. SaO(2) measured in a murine arteriole with DWP-OCT is linearly correlated (R-2=0.98) with systemic SaO(2) values recorded by a pulse-oximeter. DWP-OCT are steadily lower (10.1%) than systemic SaO(2) values except during pure oxygen breathing. DWP-OCT is insensitive to OCT intensity variations and is a candidate approach for in vivo depth-resolved quantitative imaging of microvascular SaO(2) levels. (C) 2011 Optical Society of America C1 [Kuranov, Roman V.; Kiel, Jeffrey W.; Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. [Kuranov, Roman V.; Kazmi, Shams; McElroy, Austin B.; Dunn, Andrew K.; Milner, Thomas E.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. [Duong, Timothy Q.] S Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. RP Kuranov, RV (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. EM rkuranov@yahoo.com RI Duong, Timothy/B-8525-2008; Dunn, Andrew/I-9527-2014 FU NIH [UL1RR025767, KL2RR025766, R01 EY018855, R01 EY014211]; San Antonio Area Foundation [130977]; Department of Veterans Affairs FX This research was partially supported by NIH KL2 training grants (Parent grants UL1RR025767 and KL2RR025766), San Antonio Area Foundation grant 130977 to RVK, Department of Veterans Affairs (VA MERIT Award) to TQD and NIH (R01 EY018855 and R01 EY014211) to TQD. Authors would like to thank Joe Ho of OptoWaves Inc. (San Jose, CA) for the endowment of 800 nm couplers to combine 770 nm and 800 nm photothermal excitation lights. NR 56 TC 15 Z9 15 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD NOV 21 PY 2011 VL 19 IS 24 BP 23831 EP 23844 DI 10.1364/OE.19.023831 PG 14 WC Optics SC Optics GA 865PE UT WOS:000298322000021 PM 22109408 ER PT J AU Loggia, ML Jensen, K Gollub, RL Wasan, AD Edwards, RR Kong, J AF Loggia, Marco L. Jensen, Karin Gollub, Randy L. Wasan, Ajay D. Edwards, Robert R. Kong, Jian TI The Catechol-O-Methyltransferase (COMT) val(158)met Polymorphism Affects Brain Responses to Repeated Painful Stimuli SO PLOS ONE LA English DT Article ID GENE POLYMORPHISMS; PLACEBO ANALGESIA; OPIOID RECEPTORS; SENSITIVITY; PERCEPTION; MECHANISMS; DISSOCIATION; FIBROMYALGIA; ASSOCIATION; EXPECTANCY AB Despite the explosion of interest in the genetic underpinnings of individual differences in pain sensitivity, conflicting findings have emerged for most of the identified "pain genes". Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several others. In line with findings from behavioral studies, we hypothesized that the effect of COMT on pain processing would become apparent only when the pain system was adequately challenged (i.e., after repeated pain stimulation). In the present study, we used functional Magnetic Resonance Imaging (fMRI) to investigate the brain response to heat pain stimuli in 54 subjects genotyped for the common COMT val158met polymorphism (val/val = n 22, val/met = n 20, met/met = n 12). Met/met subjects exhibited stronger pain-related fMRI signals than val/val in several brain structures, including the periaqueductal gray matter, lingual gyrus, cerebellum, hippocampal formation and precuneus. These effects were observed only for high intensity pain stimuli after repeated administration. In spite of our relatively small sample size, our results suggest that COMT appears to affect pain processing. Our data demonstrate that the effect of COMT on pain processing can be detected in presence of 1) a sufficiently robust challenge to the pain system to detect a genotype effect, and/or 2) the recruitment of pain-dampening compensatory mechanisms by the putatively more pain sensitive met homozygotes. These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation. C1 [Loggia, Marco L.; Wasan, Ajay D.; Edwards, Robert R.] Harvard Univ, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Sch Med, Boston, MA 02115 USA. [Loggia, Marco L.; Jensen, Karin; Gollub, Randy L.; Kong, Jian] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Loggia, Marco L.; Jensen, Karin; Gollub, Randy L.; Kong, Jian] MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, Boston, MA USA. [Wasan, Ajay D.; Edwards, Robert R.] Harvard Univ, Brigham & Womens Hosp, Dept Psychiat, Sch Med, Boston, MA 02115 USA. RP Loggia, ML (reprint author), Harvard Univ, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Sch Med, Boston, MA 02115 USA. EM marco@nmr.mgh.harvard.edu OI Gollub, Randy L./0000-0002-9434-4044; Jensen, Karin/0000-0003-2521-3160 FU NIH (NCCAM) [PO1-AT002048]; National Center for Research Resources (NCRR) [M01-RR-01066, UL1 RR025758-01, P41RR14075]; MIND Research Network [DE-FG03-99ER62764]; Swedish Society for Medical Research; [R01AT005280]; [R21AT00949]; [KO1AT003883]; [R21AT004497] FX Funding and support for this study came from: R01AT005280 and R21AT00949 to Randy Gollub, KO1AT003883 and R21AT004497 to Jian Kong, NIH (NCCAM) PO1-AT002048 to Bruce Rosen, M01-RR-01066 and UL1 RR025758-01 for Clinical Research Center Biomedical Imaging Core from National Center for Research Resources (NCRR), P41RR14075 for Center for Functional Neuroimaging Technologies from NCRR and the MIND Research Network, DE-FG03-99ER62764 to Bruce Rosen. Karin Jensen is supported by the Swedish Society for Medical Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 25 Z9 27 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 21 PY 2011 VL 6 IS 11 AR e27764 DI 10.1371/journal.pone.0027764 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 858IO UT WOS:000297789900019 PM 22132136 ER PT J AU Do, S Karl, WC Liang, ZL Kalra, M Brady, TJ Pien, HH AF Do, Synho Karl, W. Clem Liang, Zhuangli Kalra, Mannudeep Brady, Thomas J. Pien, Homer H. TI A decomposition-based CT reconstruction formulation for reducing blooming artifacts SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article ID ACUTE CHEST-PAIN; TOMOGRAPHY CORONARY-ANGIOGRAPHY; X-RAY CT; COMPUTED-TOMOGRAPHY; ITERATIVE METHODS; CONVERGENCE; VALIDATION; PARAMETER; SELECTION; PLAQUE AB Cardiac computed tomography represents an important advancement in the ability to assess coronary vessels. The accuracy of these non-invasive imaging studies is limited, however, by the presence of calcium, since calcium blooming artifacts lead to an over-estimation of the degree of luminal narrowing. To address this problem, we have developed a unified decomposition-based iterative reconstruction formulation, where different penalty functions are imposed on dense objects (i.e. calcium) and soft tissue. The result is a quantifiable reduction in blooming artifacts without the introduction of new distortions away from the blooming observed in other methods. Results are shown for simulations, phantoms, ex vivo, and in vivo studies. C1 [Do, Synho; Kalra, Mannudeep; Brady, Thomas J.; Pien, Homer H.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Karl, W. Clem] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Liang, Zhuangli] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA. RP Do, S (reprint author), Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. EM sdo@partners.org FU US Army; Gordon-CenSSIS program FX The authors gratefully acknowledge CIMIT, through a grant from the US Army, as well as the Gordon-CenSSIS program, for supporting this research. The authors are also grateful to Siemens for providing DRASIM and data structure information of CT sinogram. NR 33 TC 8 Z9 8 U1 0 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-9155 J9 PHYS MED BIOL JI Phys. Med. Biol. PD NOV 21 PY 2011 VL 56 IS 22 BP 7109 EP 7125 DI 10.1088/0031-9155/56/22/008 PG 17 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA 844SX UT WOS:000296768700012 PM 22025109 ER PT J AU Knopf, AC Hong, TS Lomax, A AF Knopf, Antje-Christin Hong, Theodore S. Lomax, Antony TI Scanned proton radiotherapy for mobile targets-the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article ID PAUL-SCHERRER-INSTITUTE; PARTICLE THERAPY; ORGAN MOTION; RESPIRATORY MOTION; MOVING TARGETS; MANAGEMENT; BEAMS; IRRADIATION; GANTRY AB The most advanced delivery technique for proton radiotherapy is active spot scanning. So far, predominantly static targets have been treated with active spot scanning, since mobile targets in combination with dynamic treatment delivery can lead to interplay effects, causing inhomogeneous dose distributions. One way to mitigate motion effects is re-scanning. In this study we investigate the effectiveness of re-scanning in relation to different plan parameters (number of fields, field directions, number of re-scans) as well as in respect to different motion parameters (motion amplitude, motion starting phase). A systematic study was performed for three liver patients, for which ten different plans have been calculated, respectively. The treatment plans were evaluated for three different scenarios (static, motion/single-scan-delivery, motion/re-scanned-delivery). The choice of motion parameters was based on an evaluation of the 4D CT data sets of the three patients. It is shown that the effect of motion/re-scanning per fraction is largest the fewer fields per plan are used and the more the field direction differs from the main motion direction. For amplitudes up to 6 mm, re-scanning may not be required if multiple fields are used, since only dose blurring effects appear that cannot be compensated by re-scanning. For larger motion amplitudes two planning strategies are proposed. C1 [Knopf, Antje-Christin; Lomax, Antony] Paul Scherrer Inst, Ctr Proton Therapy, Villigen, Switzerland. [Hong, Theodore S.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiat Oncol, Boston, MA USA. [Lomax, Antony] ETH, Zurich, Switzerland. RP Knopf, AC (reprint author), Paul Scherrer Inst, Ctr Proton Therapy, Villigen, Switzerland. EM antje-christin.knopf@psi.ch FU Swiss National Funds [320030-122526] FX This work was part of the Swiss National Funds grant 320030-122526. The liver 4DCT data sets were kindly provided by the radiation Oncology Department of the Massachusetts General hospital (MGH). NR 20 TC 51 Z9 51 U1 0 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-9155 J9 PHYS MED BIOL JI Phys. Med. Biol. PD NOV 21 PY 2011 VL 56 IS 22 BP 7257 EP 7271 DI 10.1088/0031-9155/56/22/016 PG 15 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA 844SX UT WOS:000296768700020 PM 22037710 ER PT J AU Taggart, DR London, WB Schmidt, ML DuBois, SG Monclair, TF Nakagawara, A De Bernardi, B Ambros, PF Pearson, ADJ Cohn, SL Matthay, KK AF Taggart, Denah R. London, Wendy B. Schmidt, Mary Lou DuBois, Steven G. Monclair, Tom F. Nakagawara, Akira De Bernardi, Bruno Ambros, Peter F. Pearson, Andrew D. J. Cohn, Susan L. Matthay, Katherine K. TI Prognostic Value of the Stage 4S Metastatic Pattern and Tumor Biology in Patients With Metastatic Neuroblastoma Diagnosed Between Birth and 18 Months of Age SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID CHILDRENS-ONCOLOGY-GROUP; IVS NEUROBLASTOMA; RISK GROUP; FAVORABLE PROGNOSIS; INFANTS; AMPLIFICATION; EXPERIENCE; PLOIDY; CLASSIFICATION; SURVIVAL AB Purpose Patients with neuroblastoma younger than 12 months of age with a 4S pattern of disease (metastases limited to liver, skin, bone marrow) have better outcomes than infants with stage 4 disease. The new International Neuroblastoma Risk Group (INRG) staging system extends age to 18 months for the 4S pattern. Our aim was to determine which prognostic features could be used for optimal risk classification among patients younger than 18 months with metastatic disease. Methods Event-free survival (EFS) and overall survival were analyzed by log-rank tests, Cox models, and survival tree regression for 656 infants with stage 4S neuroblastoma younger than 12 months of age and 1,019 patients with stage 4 disease younger than 18 months of age in the INRG database. Results Unfavorable biologic features were more frequent in infants with stage 4 disease than in infants with 4S tumors and higher overall in those age 12 to 18 months (although not different for stage 4 v 4S pattern). EFS was significantly better for infants younger than 12 months with 4S pattern than with stage 4 disease (P < .01) but similar for toddlers age 12 to 18 months with stage 4 versus 4S pattern. Among 717 patients with stage 4S pattern, patients age 12 to 18 months had worse EFS than those age younger than 12 months (P < .01). MYCN, 11q, mitosis-karyorrhexis index (MKI), ploidy, and lactate dehydrogenase were independently statistically significant predictors of EFS and more highly predictive than age or metastatic pattern. MYCN, 11q, MKI, histology, and 1p were combined in a survival tree for improved risk stratification. Conclusion Tumor biology is more critical than age or metastatic pattern for prognosis of patients age younger than 18 months with metastatic neuroblastoma and should be considered for risk stratification. C1 [Matthay, Katherine K.] Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USA. [Taggart, Denah R.; DuBois, Steven G.; Matthay, Katherine K.] Benioff Childrens Hosp, San Francisco, CA USA. [London, Wendy B.] Childrens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. [Schmidt, Mary Lou] Univ Illinois, Chicago, IL 60680 USA. [Cohn, Susan L.] Univ Chicago, Chicago, IL 60637 USA. [Monclair, Tom F.] Univ Oslo, Rikshosp, Univ Hosp, N-0027 Oslo, Norway. [Nakagawara, Akira] Chiba Canc Ctr, Chiba 2608717, Japan. [De Bernardi, Bruno] Ist Giannina Gaslini, I-16148 Genoa, Italy. [Ambros, Peter F.] St Anna Kinderkrebsforsch, Childrens Canc Res Inst, Vienna, Austria. [Pearson, Andrew D. J.] Inst Canc Res, Sutton, Surrey, England. RP Matthay, KK (reprint author), Univ Calif San Francisco, Sch Med, Dept Pediat, 505 Parnassus Ave,Box 0106, San Francisco, CA 94143 USA. EM matthayk@peds.ucsf.edu OI Ambros, Peter F./0000-0002-5507-7211; Cohn, Susan/0000-0001-5749-7650 FU National Institutes of Health [T32 CA128583-01]; William Guy Forbeck Research Foundation; Dougherty Foundation; Conner Research Fund; Campini Foundation; Mildred V. Strouss Professorship FX Supported in part by National Institutes of Health Grant No. T32 CA128583-01, William Guy Forbeck Research Foundation, Dougherty Foundation, Conner Research Fund, Campini Foundation, and Mildred V. Strouss Professorship. NR 33 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD NOV 20 PY 2011 VL 29 IS 33 BP 4358 EP 4364 DI 10.1200/JCO.2011.35.9570 PG 7 WC Oncology SC Oncology GA 851GW UT WOS:000297257400011 PM 21969516 ER PT J AU Thameem, F Puppala, S Arar, NH Blangero, J Duggirala, R Abboud, HE AF Thameem, Farook Puppala, Sobha Arar, Nedal H. Blangero, John Duggirala, Ravindranath Abboud, Hanna E. TI Genetic variants in Transient Receptor Potential cation channel, subfamily M 1 (TRPM1) and their risk of albuminuria-related traits in Mexican Americans SO CLINICA CHIMICA ACTA LA English DT Article DE TRPM1; Type 2 diabetes; Albumin to creatinine ration; Polymorphisms; Association analysis; Mexican Americans ID CORONARY-ARTERY-DISEASE; MEASURED GENOTYPE; CANDIDATE GENES; MELASTATIN; MELANOMA; LINKAGE; SEARCH; CELLS; LOCI AB Background: Evidence for linkage of albuminuria to GABRB3 marker region on chromosome 15q12 was previously reported in Mexican Americans. The objective of this study is to scan a positional candidate gene. Transient Receptor Potential cation channel, subfamily M 1 (TRPM1), for genetic variants that may contribute to the variation in albumin-to-creatinine ratio (ACR). Methods: To identify the sequence variants, the exons and 2 kb putative promoter region of TRPM1 were PCR amplified and sequenced in 32 selected individuals. Identified variants were genotyped in the entire data set (N = 670; 39 large families) by TaqMan assays. Association analyses between the sequence variants and ACR, type 2 diabetes (T2DM) and related phenotypes were carried out using a measured genotype approach as implemented in the program SOLAR. Results: Sequencing analysis identified 18 single nucleotide polymorphisms (SNPs) including 8 SNPs in the coding regions, 7 SNPs in the promoter region and 3 SNPs in introns. Of the 8 SNPs identified in the coding regions, 3 were non synonymous [Met(1)Thr, Ser(32)Asn, Val(1395)Ile] and one SNP caused stop codon (Glu1375/*). Of the SNPs examined, none of them exhibited statistically significant association with ACR after accounting for the effect of age, sex, diabetes, duration of diabetes, systolic blood pressure and anti-hypertensive medications. However, a SNP (rs11070811) located in the putative promoter region showed a modest association with triglycerides levels (P= 0.039). Conclusion: The present investigation found no evidence for an association between sequence variation at the TRPM1 gene and ACR in Mexican Americans, although it appears to have modest influence on T2DM risk factors. (C) 2011 Elsevier B.V. All rights reserved. C1 [Thameem, Farook; Arar, Nedal H.; Abboud, Hanna E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Nephrol, San Antonio, TX 78229 USA. [Puppala, Sobha; Blangero, John; Duggirala, Ravindranath] Texas Biomed Res Inst, Dept Genet, San Antonio, TX 78227 USA. [Arar, Nedal H.; Abboud, Hanna E.] S Texas Vet Healthcare Syst, San Antonio, TX 78229 USA. RP Thameem, F (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Nephrol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM thameem@uthscsa.edu FU American Heart Association; Diabetes Action Research and Education Foundation; American Society of Nephrology; Satellite Health Care; George O'Brien Kidney Research Center [P50 DK061597]; VA-Merit Review; National Institute of Diabetes, Digestive and Kidney Diseases [DK42273, DK47482, DK53889]; National Center for Research Resources [UL1 RR025767, KL2 RR025766] FX We thank members of the SAFDGS for their participation and cooperation. This study was supported by the American Heart Association, Diabetes Action Research and Education Foundation, American Society of Nephrology, Satellite Health Care, George O'Brien Kidney Research Center (P50 DK061597), VA-Merit Review, and by grants from the National Institute of Diabetes, Digestive and Kidney Diseases (DK42273, DK47482 and DK53889). This work was also supported by the National Center for Research Resources contracts UL1 RR025767 and KL2 RR025766 for the Institute for Integration of Medicine and Science. We also thank the General Clinical Research Center, and South Texas Healthcare System. NR 33 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD NOV 20 PY 2011 VL 412 IS 23-24 BP 2058 EP 2062 DI 10.1016/j.cca.2011.03.024 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 843QC UT WOS:000296686100007 PM 21439949 ER PT J AU Mahon, JL Beam, CA Marcovina, SM Boulware, DC Palmer, JP Winter, WE Skyler, JS Krischer, JP AF Mahon, Jeffrey L. Beam, Craig A. Marcovina, Santica M. Boulware, David C. Palmer, Jerry P. Winter, William E. Skyler, Jay S. Krischer, Jeffrey P. CA Type 1 Diabet TrialNet Study Grp TI Comparison of two insulin assays for first-phase insulin release in type 1 diabetes prediction and prevention studies SO CLINICA CHIMICA ACTA LA English DT Article DE First-phase insulin release; Insulin radioimmunoassay; Insulin immunoenzymometric assay; Prediction and prevention of type 1 diabetes ID INTRAVENOUS GLUCOSE; INTERVENTION TRIAL; STANDARDIZATION; PROGRESSION; RELATIVES; RISK AB Background: Detection of below-threshold first-phase insulin release or FPIR (1 + 3 minute insulin concentrations during an intravenous glucose tolerance test [IVGTT]) is important in type 1 diabetes prediction and prevention studies including the TrialNet Oral Insulin Prevention Trial. We assessed whether an insulin immunoenzymometric assay (IEMA) could replace the less practical but current standard of a radioimmunoassay (RIA) for FPIR. Methods: One hundred thirty-three islet autoantibody positive relatives of persons with type 1 diabetes underwent 161 IVGTTs. Insulin concentrations were measured by both assays in 1056 paired samples. A rule classifying FPIR (below-threshold, above-threshold, uncertain) by the IEMA was derived and validated against FPIR by the RIA. Results: The insulin IEMA-based rule accurately classified below- and above-threshold FPIRs by the RIA in 110/161(68%) IVGTTs, but was uncertain in 51/161 (32%) tests for which FPIR by RIA is needed. An uncertain FPIR by the IEMA was more likely among below-threshold vs above-threshold FPIRs by the RIA (64%[30/47] vs. 18% [21/114], respectively; p<0.05). Conclusions: An insulin IEMA for FPIR in subjects at risk for type 1 diabetes accurately determined below- and above-threshold FPIRs in 2/3 of tests relative to the current standard of the insulin RIA. but could not reliably classify the remaining FPIRs. TrialNet is limiting the insulin RIA for FPIR to the latter given the practical advantages of the more specific IEMA. (C) 2011 Elsevier B.V. All rights reserved. C1 [Mahon, Jeffrey L.] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada. [Mahon, Jeffrey L.] Univ Western Ontario, Dept Med, London, ON, Canada. [Beam, Craig A.; Boulware, David C.; Krischer, Jeffrey P.] Univ S Florida, Dept Pediat, Pediat Epidemiol Ctr, Tampa, FL 33620 USA. [Marcovina, Santica M.] Univ Washington, NW Lipid Metab & Diabet Res Labs, Seattle, WA 98195 USA. [Palmer, Jerry P.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Winter, William E.] Univ Florida, Dept Pathol, Gainesville, FL 32611 USA. [Winter, William E.] Univ Florida, Dept Immunol & Lab Med, Gainesville, FL USA. [Skyler, Jay S.] Univ Miami, Div Endocrinol, Miami, FL USA. RP Mahon, JL (reprint author), Robarts Clin Trials, POB 5015,100 Perth Dr, London, ON N6A 5K8, Canada. EM JLMahon@Ihsc.on.ca RI Skyler, Jay/F-4211-2016 FU National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; Juvenile Diabetes Research Foundation International; American Diabetes Diabetes Association FX TrialNet is funded by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and National Center for Research Resources; the Juvenile Diabetes Research Foundation International; and the American Diabetes Diabetes Association. NR 16 TC 9 Z9 9 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD NOV 20 PY 2011 VL 412 IS 23-24 BP 2128 EP 2131 DI 10.1016/j.cca.2011.07.019 PG 4 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 843QC UT WOS:000296686100018 PM 21843518 ER PT J AU Richardson, PG Spencer, A Cannel, P Harrison, SJ Catley, L Underhill, C Zimmerman, TM Hofmeister, CC Jakubowiak, AJ Laubach, JP Palladino, MA Longenecker, AM Lay, A Wear, S Lloyd, GK Hannah, AL Reich, S Spear, MA Anderson, KC AF Richardson, Paul G. Spencer, Andrew Cannel, Paul Harrison, Simon J. Catley, Laurence Underhill, Craig Zimmerman, Todd M. Hofmeister, Craig C. Jakubowiak, Andrzej J. Laubach, Jacob P. Palladino, Michael A. Longenecker, Angie M. Lay, Ana Wear, Sandra Lloyd, G. Kenneth Hannah, Alison L. Reich, Steve Spear, Matthew A. Anderson, Kenneth C. TI Phase 1 Clinical Evaluation of Twice-Weekly Marizomib (NPI-0052), a Novel Proteasome Inhibitor, in Patients with Relapsed/Refractory Multiple Myeloma (MM) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Spencer, Andrew] Alfred Hosp, Melbourne, Vic, Australia. [Cannel, Paul] Royal Perth Hosp, Perth, WA, Australia. [Harrison, Simon J.] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia. [Catley, Laurence] Mater Adult Hosp, Brisbane, Qld, Australia. [Underhill, Craig] Border Med Oncol, Wodonga, Vic, Australia. [Zimmerman, Todd M.] Univ Chicago, Dept Med, Chicago, IL 60637 USA. [Hofmeister, Craig C.] Ohio State Univ, Med Ctr, Div Hematol, Columbus, OH 43210 USA. [Jakubowiak, Andrzej J.] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA. [Laubach, Jacob P.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Dis Ctr, Boston, MA 02115 USA. [Palladino, Michael A.; Longenecker, Angie M.; Lay, Ana; Lloyd, G. Kenneth; Hannah, Alison L.; Reich, Steve; Spear, Matthew A.] Nereus Pharmaceut Inc, San Diego, CA USA. [Wear, Sandra] Multiple Myeloma Res Consortium, Norwalk, CT USA. RI Catley, Laurence/E-5313-2013 NR 0 TC 0 Z9 0 U1 4 U2 7 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 140 EP 141 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100303 ER PT J AU Richardson, PG Baz, R Wang, LH Jakubowiak, AJ Berg, D Liu, GH Gupta, N Di Bacco, A Hui, AM Lonial, S AF Richardson, Paul G. Baz, Rachid Wang, Luhua Jakubowiak, Andrzej J. Berg, Deborah Liu, Guohui Gupta, Neeraj Di Bacco, Alessandri Hui, Ai-Min Lonial, Sagar TI Investigational Agent MLN9708, An Oral Proteasome Inhibitor, in Patients (Pts) with Relapsed and/or Refractory Multiple Myeloma (MM): Results From the Expansion Cohorts of a Phase 1 Dose-Escalation Study SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Baz, Rachid] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL 33612 USA. [Wang, Luhua] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Jakubowiak, Andrzej J.] Univ Michigan, Ann Arbor, MI 48109 USA. [Berg, Deborah; Liu, Guohui; Gupta, Neeraj; Di Bacco, Alessandri; Hui, Ai-Min] Millennium Pharmaceut Inc, Cambridge, MA USA. [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 140 EP 140 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100302 ER PT J AU Anasetti, C Logan, BR Lee, SJ Waller, EK Weisdorf, DJ Wingard, JR Cutler, CS Westervelt, P Woolfrey, A Couban, S Johnston, L Maziarz, RT Pulsipher, M Anderlini, P Bensinger, WI Leitman, SF Rowley, SD Carter, SL Horowitz, MM Confer, DL AF Anasetti, Claudio Logan, Brent R. Lee, Stephanie J. Waller, Edmund K. Weisdorf, Daniel J. Wingard, John R. Cutler, Corey S. Westervelt, Peter Woolfrey, Ann Couban, Stephen Johnston, Laura Maziarz, Richard T. Pulsipher, Michael Anderlini, Paolo Bensinger, William I. Leitman, Susan F. Rowley, Scott D. Carter, Shelly L. Horowitz, Mary M. Confer, Dennis L. TI Increased Incidence of Chronic Graft-Versus-Host Disease (GVHD) and No Survival Advantage with Filgrastim-Mobilized Peripheral Blood Stem Cells (PBSC) Compared to Bone Marrow (BM) Transplants From Unrelated Donors: Results of Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Protocol 0201, a Phase III, Prospective, Randomized Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Anasetti, Claudio] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. [Bensinger, William I.] Fred Hutchinson Canc Res Ctr, Clin Div, Seattle, WA 98104 USA. [Waller, Edmund K.] Emory Univ, Winship Canc Inst, Dept Heamtol Med Oncol, Atlanta, GA 30322 USA. [Weisdorf, Daniel J.] Univ Minnesota, Med Ctr, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA. [Wingard, John R.] Univ Florida, Shands Canc Ctr, Gainesville, FL USA. [Cutler, Corey S.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Westervelt, Peter] Washington Univ, Sch Med, Dept Med, Siteman Canc Ctr, St Louis, MO 63110 USA. [Couban, Stephen] Dalhousie Univ, Halifax, NS, Canada. [Johnston, Laura] Stanford Univ, Med Ctr, Stanford, CA 94305 USA. [Maziarz, Richard T.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Pulsipher, Michael] Univ Utah, Med Ctr, Salt Lake City, UT USA. [Anderlini, Paolo] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA. [Leitman, Susan F.] NIH, Dept Transfus Med, Bethesda, MD 20892 USA. [Rowley, Scott D.] Hackensack Univ, John Theurer Canc Ctr, Med Ctr, Hackensack, NJ USA. [Carter, Shelly L.] EMMES Corp, Rockville, MD USA. [Horowitz, Mary M.] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. [Confer, Dennis L.] Natl Marrow Donor Program, Minneapolis, MN USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 3 EP 3 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100002 ER PT J AU Liel, MS Klein, R Recht, M Greenberg, DL Taylor, J AF Liel, Meghan S. Klein, Robert Recht, Michael Greenberg, Daniel L. Taylor, Jason TI Reduced Bone Mineral Density in Factor VIII Deficient Mice and the Role of Inflammatory Cytokines SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Klein, Robert] Oregon Hlth & Sci Univ, Bone & Mineral Res Unit, Dept Endocrinol, Portland, OR 97201 USA. [Recht, Michael; Greenberg, Daniel L.] Oregon Hlth & Sci Univ, Hemophilia Ctr, Portland, OR 97201 USA. [Taylor, Jason] Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 14 EP 14 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100022 ER PT J AU Thomas, GM Brill, A Wagner, DD AF Thomas, Grace M. Brill, Alexander Wagner, Denisa D. TI Cancer-Associated Thrombosis: Cancer Cell-Derived Microparticles As a Trigger of Venous Thrombosis in a Mouse Model of Flow Restriction SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Thomas, Grace M.; Wagner, Denisa D.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Brill, Alexander] Childrens Hosp, Program Cellular & Mol Med, Immune Dis Inst, Boston, MA 02115 USA. RI Thomas, Grace/G-1020-2011 OI Thomas, Grace/0000-0003-4502-7154 NR 0 TC 0 Z9 1 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 19 EP 19 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100035 ER PT J AU Gao, CY Xie, R Wang, J Yu, CY Tan, XY Li, JA Xie, RJ Zhou, J Gilbert, GE Shi, JL AF Gao, Chunyan Xie, Rui Wang, Jing Yu, Chengyuan Tan, Xiaoyan Li, Jianan Xie, Rujuan Zhou, Jin Gilbert, Gary E. Shi, Jialan TI Erythrocytes and Platelets May Contribute to Hypercoagulability In Nephrotic Syndrome Through Enhanced Phosphatidylserine Exposure and Microparticles Release SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Gao, Chunyan; Xie, Rui; Wang, Jing; Tan, Xiaoyan; Li, Jianan; Zhou, Jin; Shi, Jialan] Harbin Med Coll, Hlth Minist Key Lab Cell Transplantat, Heilongjiang Inst Hematol & Oncol, Dept Hematol,Hosp 1, Harbin, Peoples R China. [Yu, Chengyuan; Xie, Rujuan] Harbin Med Coll, Dept Nephrol, Hosp 1, Harbin, Peoples R China. [Gilbert, Gary E.] Harvard Univ, Brigham & Womens Hosp, Sch Med, VA Boston Healthcare Syst,Dept Med, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 20 EP 20 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100037 ER PT J AU Thomas, GM Carbo, C Curtis, B Martinod, K Mazo, IB Schatzberg, D Cifuni, SM Fuchs, TA von Andrian, UH Hartwig, JH Aster, RH Wagner, DD AF Thomas, Grace M. Carbo, Carla Curtis, Brian Martinod, Kimberly Mazo, Irina B. Schatzberg, Daphne Cifuni, Stephen M. Fuchs, Tobias A. von Andrian, Ulrich H. Hartwig, John H. Aster, Richard H. Wagner, Denisa D. TI Extracellular DNA Traps Are Associated with Pathogenesis of TRALI in Humans and Mice SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Thomas, Grace M.; Carbo, Carla; Mazo, Irina B.; Fuchs, Tobias A.; Wagner, Denisa D.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Curtis, Brian; Aster, Richard H.] Blood Ctr Wisconsin, Blood Res Inst, Milwaukee, WI USA. [Curtis, Brian; Aster, Richard H.] Blood Ctr Wisconsin, Platelet & Neutrophil Immunol Lab, Milwaukee, WI USA. [Curtis, Brian; Aster, Richard H.] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA. [Martinod, Kimberly; Schatzberg, Daphne; Cifuni, Stephen M.] Childrens Hosp, Immune Dis Inst, Program Cellular & Mol Med, Boston, MA 02115 USA. [von Andrian, Ulrich H.] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA USA. [Hartwig, John H.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Translat Med,Dept Med, Boston, MA 02115 USA. RI Thomas, Grace/G-1020-2011 OI Thomas, Grace/0000-0003-4502-7154 NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 20 EP 21 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100038 ER PT J AU Baron, DM Yu, BL Lei, C Bagchi, A Beloiartsev, A Steinbicker, AU Stowell, CP Malhotra, R Bloch, KD Zapol, WM AF Baron, David M. Yu, Binglan Lei, Chong Bagchi, Aranya Beloiartsev, Arkadi Steinbicker, Andrea U. Stowell, Christopher P. Malhotra, Rajeev Bloch, Kenneth D. Zapol, Warren M. TI Pulmonary Hypertension During Autologous Transfusion of Stored Blood Is Prevented by Nitric Oxide Inhalation in Lambs SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Baron, David M.; Yu, Binglan; Lei, Chong; Bagchi, Aranya; Beloiartsev, Arkadi; Steinbicker, Andrea U.; Bloch, Kenneth D.; Zapol, Warren M.] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA. [Stowell, Christopher P.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Malhotra, Rajeev] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 21 EP 22 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100040 ER PT J AU Yu, BL Lei, C Baron, DM Steinbicker, AU Bloch, KD Zapol, WM AF Yu, Binglan Lei, Chong Baron, David M. Steinbicker, Andrea U. Bloch, Kenneth D. Zapol, Warren M. TI Endothelial Deficiency Augments and Inhaled Nitric Oxide Prevents the Adverse Hemodynamic Effects of Transfusing Syngeneic Stored Blood in Mice SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Yu, Binglan; Lei, Chong; Baron, David M.; Steinbicker, Andrea U.; Bloch, Kenneth D.; Zapol, Warren M.] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 21 EP 21 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100039 ER PT J AU Weigert, O Lane, AA Bird, L Kopp, N Toms, AV Gaul, C Vangrevelinghe, E De Pover, A Regnier, CH Erdmann, D Hofmann, F Eck, M Kung, AL Radimerski, T Weinstock, DM AF Weigert, Oliver Lane, Andrew A. Bird, Liat Kopp, Nadja Toms, Angela V. Gaul, Christoph Vangrevelinghe, Eric De Pover, Alain Regnier, Catherine H. Erdmann, Dirk Hofmann, Francesco Eck, Michael Kung, Andrew L. Radimerski, Thomas Weinstock, David M. TI Genetic Resistance to JAK2 Enzymatic Inhibitors Is Overcome by HSP90 Inhibition SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kung, Andrew L.] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Gaul, Christoph; Vangrevelinghe, Eric; De Pover, Alain; Regnier, Catherine H.; Erdmann, Dirk; Hofmann, Francesco; Radimerski, Thomas] Novartis Inst Biomed Res, Basel, Switzerland. [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Kung, Andrew L.] Childrens Hosp Boston, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 30 EP 30 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100063 ER PT J AU Fleischman, AG Sanda, T Gutierrez, A Luty, SB Willis, SG Look, AT Druker, BJ Tyner, JW AF Fleischman, Angela G. Sanda, Takaomi Gutierrez, Alejandro Luty, Samuel B. Willis, Stephanie G. Look, A. Thomas Druker, Brian J. Tyner, Jeffrey W. TI Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Fleischman, Angela G.] Oregon & Hlth & Sci Univ, Knight Canc Inst, Div Hematol & Med Oncol, Portland, OR USA. [Sanda, Takaomi; Gutierrez, Alejandro] Dana Farber Canc Inst, Somerville, NJ USA. [Look, A. Thomas] Dana Farber Canc Inst, Boston, MA 02115 USA. [Druker, Brian J.; Tyner, Jeffrey W.] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 36 EP 36 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100075 ER PT J AU Douer, D Zickl, L Schiffer, CA Appelbaum, FR Feusner, JH Shepherd, LE Willman, CL Bloomfield, CD Rowe, JM Wiernik, PH Tallman, MS AF Douer, Dan Zickl, Lynette Schiffer, Charles A. Appelbaum, Frederick R. Feusner, James H. Shepherd, Lois E. Willman, Cheryl L. Bloomfield, Clara D. Rowe, Jacob M. Wiernik, Peter H. Tallman, Martin S. TI Late Relapses Following All-Trans Retinoic Acid for Acute Promyelocytic Leukemia Are Uncommon, Respond Well to Salvage Therapy and Occur Independently of Prognostic Factors At Diagnosis: Long-Term Follow-up of North American Intergroup Study I0129 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Douer, Dan; Tallman, Martin S.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Zickl, Lynette] Dana Farber Canc Inst, Ctr Stat, Brookline, MA USA. [Schiffer, Charles A.] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA. [Appelbaum, Frederick R.] Univ Washington, Seattle, WA 98195 USA. [Feusner, James H.] Childrens Hosp & Res Ctr, Oakland, CA USA. [Shepherd, Lois E.] Queens Univ, Kingston, ON, Canada. [Willman, Cheryl L.] Univ New Mexico, Ctr Canc, Albuquerque, NM 87131 USA. [Bloomfield, Clara D.] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA. [Rowe, Jacob M.] Technion Israel Inst Technol, Rambam Med Ctr, Haifa, Israel. [Wiernik, Peter H.] Montefiore Med Ctr, Bronx, NY 10467 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 40 EP 40 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100084 ER PT J AU Winter, JN Hong, FX Rimsza, LM LeBlanc, M Variakojis, D Krajewska, M Habermann, TM Melnick, A Weick, JK Pollock, F Botros, I Reed, JC Fisher, RI Kahl, BS Horning, SJ Gascoyne, RD AF Winter, Jane N. Hong, Fangxin Rimsza, Lisa M. LeBlanc, Michael Variakojis, Daina Krajewska, Maryla Habermann, Thomas M. Melnick, Ari Weick, James K. Pollock, Frederick Botros, Ihab Reed, John C. Fisher, Richard I. Kahl, Brad S. Horning, Sandra J. Gascoyne, Randy D. TI Gene Risk Scores Based on Expression of 6 Genes Quanitated by Nuclease Protection Assay in Formalin Fixed Paraffin-Embedded Tissue (FFPET) Specimens From CHOP and RCHOP Treated Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Predict Outcome: An ECOG and SWOG Study SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Winter, Jane N.] ECOG, Lymphoma Comm, Chicago, IL USA. [Hong, Fangxin] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Rimsza, Lisa M.] Univ Arizona, Dept Pathol, Tucson, AZ USA. [LeBlanc, Michael] SW Oncol Grp, Lymphoma Comm, San Antonio, TX USA. [Variakojis, Daina] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA. [Krajewska, Maryla; Reed, John C.] Sanford Burnham Med Res Inst, La Jolla, CA USA. [Habermann, Thomas M.] Mayo Clin, Div Hematol, Rochester, MN USA. [Melnick, Ari] Weill Cornell Med Coll, Div Hematol & Oncol, New York, NY USA. [Weick, James K.] VA Med Ctr, Riviera Beach, FL USA. [Pollock, Frederick] HTG Inc, Corp Dev Res, Tucson, AZ USA. [Botros, Ihab] HTG Inc, Res, Tucson, AZ USA. [Fisher, Richard I.] Univ Rochester, James P Wilmot Canc Ctr, Rochester, NY USA. [Kahl, Brad S.] Univ Wisconsin, Dept Med Hematol Oncol, Madison, WI USA. [Horning, Sandra J.] Genentech Inc, Clin Dev Hem Onc, San Francisco, CA 94080 USA. [Gascoyne, Randy D.] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 41 EP 42 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100088 ER PT J AU Zhou, YS Liu, X Xu, L Yang, G Cao, Y Hunter, Z Treon, SP AF Zhou, Yangsheng Liu, Xia Xu, Lian Yang, Guang Cao, Yang Hunter, Zachary Treon, Steven P. TI Aberrant Expression of Oct-2, Spi-B, and Id2/Id1 Is Associated with Repression of Plasma Cell Differentiation in Waldenstrom's Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Zhou, Yangsheng; Liu, Xia; Xu, Lian; Yang, Guang; Cao, Yang; Hunter, Zachary] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Treon, Steven P.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 41 EP 41 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100087 ER PT J AU Cortes, JE Kim, DW Pinilla-Ibarz, J Le Coutre, PD Chuah, C Nicolini, FE Paquette, R Apperley, JF DiPersio, JF Khoury, HJ Rea, D Talpaz, M DeAngelo, DJ Abruzzese, E Baccarani, M Mueller, MC Gambacorti-Passerini, C Wong, S Lustgarten, S Turner, CD Rivera, VM Clackson, T Haluska, F Kantarjian, HM AF Cortes, Jorge E. Kim, Dong-Wook Pinilla-Ibarz, Javier Le Coutre, Philipp D. Chuah, Charles Nicolini, Franck E. Paquette, Ron Apperley, Jane F. DiPersio, John F. Khoury, H. Jean Rea, Delphine Talpaz, Moshe DeAngelo, Daniel J. Abruzzese, Elisabetta Baccarani, Michele Mueller, Martin C. Gambacorti-Passerini, Carlo Wong, Stephane Lustgarten, Stephanie Turner, Christopher D. Rivera, Victor M. Clackson, Tim Haluska, Frank Kantarjian, Hagop M. CA PACE Study Grp TI Initial Findings From the PACE Trial: A Pivotal Phase 2 Study of Ponatinib in Patients with CML and Ph+ ALL Resistant or Intolerant to Dasatinib or Nilotinib, or with the T315I Mutation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Cortes, Jorge E.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Kim, Dong-Wook] Catholic Univ Korea, Seoul St Marys Hosp, Seoul, South Korea. [Le Coutre, Philipp D.] Charite, D-13353 Berlin, Germany. [Pinilla-Ibarz, Javier] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Chuah, Charles] Duke NUS Grad Med Sch, Singapore Gen Hosp, Singapore, Singapore. [Nicolini, Franck E.] Hop Edouard Herriot, Lyon, France. [Paquette, Ron] Univ Calif Los Angeles, Ronald Reagan UCLA Med Ctr, Los Angeles, CA USA. [Apperley, Jane F.] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Dept Haematol, London, England. [DiPersio, John F.] Washington Univ, Sch Med, St Louis, MO USA. [Khoury, H. Jean] Emory Winship Canc Inst, Atlanta, GA USA. [Rea, Delphine] Hop St Louis, Serv Malad Sang, Paris, France. [Talpaz, Moshe] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA. [DeAngelo, Daniel J.] Childrens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. [Baccarani, Michele] S Orsola Malpighi Univ Hosp, Dept Hematol Oncol L&A Seragnoli, Bologna, Italy. [Abruzzese, Elisabetta] Osped S Eugenio, Rome, Italy. [Mueller, Martin C.] Univ Med Mannheim, Med Klin 3, Mannheim, Germany. [Gambacorti-Passerini, Carlo] Univ Milano Bicocca, Azienda Osped San Gerardo, Unita Ric Clin Ematol, Monza, Italy. [Wong, Stephane] MolecularMD Corp, Portland, OR USA. [Lustgarten, Stephanie; Turner, Christopher D.; Rivera, Victor M.; Clackson, Tim; Haluska, Frank] ARIAD Pharmaceut Inc, Cambridge, MA USA. [Kantarjian, Hagop M.] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA. NR 0 TC 4 Z9 4 U1 0 U2 6 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 52 EP 53 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100110 ER PT J AU Koreth, J Pidala, J Perez, WS Deeg, HJ Garcia-Manero, G Malcovati, L Cazzola, M Park, S Itzykson, R Ades, L Fenaux, P Jadersten, M Hellstrom-Lindberg, E Gale, RP Beach, CL Greenberg, PL Tallman, MS DiPersio, JF Bunjes, D Weisdorf, DJ Cutler, CS AF Koreth, John Pidala, Joseph Perez, Waleska S. Deeg, H. Joachim Garcia-Manero, Guillermo Malcovati, Luca Cazzola, Mario Park, Sophie Itzykson, Raphael Ades, Lionel Fenaux, Pierre Jaedersten, Martin Hellstrom-Lindberg, Eva Gale, Robert Peter Beach, C. L. Greenberg, Peter L. Tallman, Martin S. DiPersio, John F. Bunjes, Donald Weisdorf, Daniel J. Cutler, Corey S. TI A Decision Analysis of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients with De-Novo Myelodysplastic Syndrome (MDS): Early Transplantation Offers Survival Benefit in Higher-Risk MDS SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Koreth, John; Cutler, Corey S.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Pidala, Joseph] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Perez, Waleska S.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Deeg, H. Joachim] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Garcia-Manero, Guillermo] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA. [Malcovati, Luca; Cazzola, Mario] Fdn IRCCS Policlin San Matteo, Dept Hematol Oncol, Pavia, Italy. [Malcovati, Luca; Cazzola, Mario] Univ Pavia, I-27100 Pavia, Italy. [Park, Sophie] Univ Paris 05, Hop Cochin, Paris, France. [Itzykson, Raphael] Hop Avicenne, Hematol Serv, F-93009 Bobigny, France. [Ades, Lionel] Grp Francophone Myelodysplasies, Bobigny, France. [Fenaux, Pierre] Univ Paris 13, AP HP, Hop Avicenne, Bobigny, France. [Jaedersten, Martin] Karolinska Inst, Dept Med, Div Hematol, Stockholm, Sweden. [Hellstrom-Lindberg, Eva] Karolinska Inst, Dept Med, Div Hem, Stockholm, Sweden. [Gale, Robert Peter; Beach, C. L.] Celgene Corp, Summit, NJ USA. [Greenberg, Peter L.] Stanford Univ, Div Hematol, Stanford Canc Ctr, Stanford, CA 94305 USA. [Tallman, Martin S.] Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY 10021 USA. [DiPersio, John F.] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA. [Bunjes, Donald] Univ Ulm, Ulm, Germany. [Weisdorf, Daniel J.] Univ Minnesota, Med Ctr, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA. RI PARK, Sophie/M-6597-2014 NR 0 TC 3 Z9 3 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 56 EP 57 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100116 ER PT J AU Deshpande, A Reddy, MM Schade, G Ray, A Chowdary, TK Griffin, JD Sattler, M AF Deshpande, Anagha Reddy, Mamatha M. Schade, Georg Ray, Arghya Chowdary, Tirumala K. Griffin, James D. Sattler, Martin TI Kinase Domain Mutations in JAK2V617F Confer Resistance to the Novel JAK2 Inhibitor Ruxolitinib SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Chowdary, Tirumala K.] Tufts Univ, Sch Med, Boston, MA 02111 USA. [Griffin, James D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 61 EP 61 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100126 ER PT J AU Gorgun, G Hideshima, T Raje, NS Mimura, N Bradner, JE Cirstea, D Santo, L Tai, YT Sellitto, M Hu, YG Fabre, C Ohguchi, H Minami, J Richardson, PG Munshi, NC Anderson, KC AF Gorgun, Gullu Hideshima, Teru Raje, Noopur S. Mimura, Naoya Bradner, James E. Cirstea, Diana Santo, Loredana Tai, Yu-Tzu Sellitto, Michael Hu, Yiguo Fabre, Claire Ohguchi, Hiroto Minami, Jiro Richardson, Paul G. Munshi, Nikhil C. Anderson, Kenneth C. TI Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Hideshima, Teru; Bradner, James E.; Sellitto, Michael; Hu, Yiguo; Fabre, Claire; Ohguchi, Hiroto; Minami, Jiro; Richardson, Paul G.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol,Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. [Cirstea, Diana; Santo, Loredana] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc, Boston, MA USA. [Munshi, Nikhil C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Munshi, Nikhil C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 62 EP 62 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100129 ER PT J AU Mimura, N Fulciniti, M Gorgun, G Tai, YT Cirstea, DD Santo, L Hu, YG Fabre, C Minami, J Ohguchi, H Kiziltepe, T Ikeda, H Kawano, Y Blumenthal, M Tam, V Kertesz, NL Hokenson, M Zeng, QP Patterson, JB Richardson, PG Munshi, NC Anderson, KC AF Mimura, Naoya Fulciniti, Mariateresa Gorgun, Gullu Tai, Yu-Tzu Cirstea, Diana D. Santo, Loredana Hu, Yiguo Fabre, Claire Minami, Jiro Ohguchi, Hiroto Kiziltepe, Tanyel Ikeda, Hiroshi Kawano, Yutaka Blumenthal, Martina Tam, Victor Kertesz, Nathalie L. Hokenson, Mark Zeng, Qingping Patterson, John B. Richardson, Paul G. Munshi, Nikhil C. Anderson, Kenneth C. TI Blockade of XBP1 Splicing by Inhibition of IRE1 alpha Is a Promising Therapeutic Option in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Mimura, Naoya; Fulciniti, Mariateresa; Gorgun, Gullu; Tai, Yu-Tzu; Hu, Yiguo; Fabre, Claire; Minami, Jiro; Ohguchi, Hiroto; Richardson, Paul G.; Munshi, Nikhil C.; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol,Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. [Cirstea, Diana D.; Santo, Loredana] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc, Boston, MA USA. [Kiziltepe, Tanyel] Univ Notre Dame, Notre Dame, IN 46556 USA. [Ikeda, Hiroshi] Sapporo Med Univ, Dept Internal Med 1, Sapporo, Hokkaido, Japan. [Kawano, Yutaka] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Blumenthal, Martina; Tam, Victor; Kertesz, Nathalie L.; Hokenson, Mark; Zeng, Qingping; Patterson, John B.] MannKind Corp, Valencia, CA USA. RI Luste, Elena/D-3472-2016 OI Luste, Elena/0000-0003-3691-9038 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 64 EP 65 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100134 ER PT J AU Tian, Z Zhao, JJ Lin, JH Chauhan, D Anderson, KC AF Tian, Ze Zhao, Jian-Jun Lin, Jianhong Chauhan, Dharminder Anderson, Kenneth C. TI Investigational Agent MLN9708 Target Tumor Suppressor MicroRNA-33b in Multiple Myeloma Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Chauhan, Dharminder] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Chauhan, Dharminder] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 66 EP 66 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100137 ER PT J AU Jacobsohn, D Lee, SJ Kurland, B Cutler, CS Pidala, J Carpenter, PA Chai, S Arai, S Arora, M Palmer, J Martin, PJ Pavletic, SZ Flowers, MED AF Jacobsohn, David Lee, Stephanie J. Kurland, Brenda Cutler, Corey S. Pidala, Joseph Carpenter, Paul A. Chai, Shawn Arai, Sally Arora, Mukta Palmer, Jeanne Martin, Paul J. Pavletic, Steven Z. Flowers, Mary E. D. TI Change in NIH Skin Score 0-3 Correlates with Provider- and Patient-Reported Skin Changes and Overall Survival: Results From the Chronic Gvhd Consortium SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Jacobsohn, David] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Lee, Stephanie J.; Kurland, Brenda; Carpenter, Paul A.; Chai, Shawn; Martin, Paul J.; Flowers, Mary E. D.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Cutler, Corey S.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Pidala, Joseph] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. [Arai, Sally] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Arora, Mukta] Univ Minnesota, Minneapolis, MN USA. [Palmer, Jeanne] MCW & Froedtert Clin Canc Ctr, Milwaukee, WI USA. [Pavletic, Steven Z.] NCI, Expt Transplantat & hnmunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 73 EP 74 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100152 ER PT J AU Pai, SY Notarangelo, LD Harris, C Cattaneo, F Wladkowski, M Armant, M Kao, GS Wielgosz, M Nienhuis, AW Modlich, U Brugman, M Schambach, A Rothe, M Thornhill, SI Gaspar, HB Parsley, K Cooray, S Grassman, E Bushman, F Shupien, S Oleastro, M Hacein-Bey-Abina, S Fischer, A Cavazzana-Calvo, M Malik, P Filipovich, A Kohn, DB Baum, C Williams, DA Thrasher, AI AF Pai, Sung-Yun Notarangelo, Luigi Daniele Harris, Chad Cattaneo, Federica Wladkowski, Matthew Armant, Myriam Kao, Grace S. Wielgosz, Matthew Nienhuis, Arthur W. Modlich, Ute Brugman, Martijn Schambach, Axel Rothe, Michael Thornhill, Susannah I. Gaspar, H. Bobby Parsley, Kathryn Cooray, Samantha Grassman, Elke Bushman, Frederic Shupien, Sally Oleastro, Matias Hacein-Bey-Abina, Salima Fischer, Alain Cavazzana-Calvo, Marina Malik, Punam Filipovich, Alexandra Kohn, Donald B. Baum, Christopher Williams, David A. Thrasher, Adrian I. TI Somatic Gene Therapy for X-Linked Severe Combined Immunodeficiency Using a Self-Inactivating Modified Gammaretroviral Vector Results in An Improved Preclinical Safety Profile and Early Clinical Efficacy in a Human Patient SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Harris, Chad] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA. [Armant, Myriam] Ctr Human Cell Therapy, Immune Dis Inst, Boston, MA USA. [Kao, Grace S.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Nienhuis, Arthur W.] St Jude Childrens Hosp, Dept Hematol, Memphis, TN 38105 USA. [Modlich, Ute] Hannover Med Sch, D-3000 Hannover, Germany. [Brugman, Martijn] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Leiden, Netherlands. [Schambach, Axel; Rothe, Michael] Hannover Med Sch, Dept Expt Hematol, D-3000 Hannover, Germany. [Thornhill, Susannah I.] GlaxoSmithKline Inc, Brentford, England. [Parsley, Kathryn; Thrasher, Adrian I.] Inst Childrens Hlth, Mol Immunol Unit, London, England. [Parsley, Kathryn] Great Ormond St Hosp Sick Children, London WC1N 3JH, England. [Bushman, Frederic; Malik, Punam] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA. [Bushman, Frederic] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA. [Kohn, Donald B.] Univ Calif Los Angeles, MMG & Pediat, Los Angeles, CA USA. [Oleastro, Matias] Hosp Pediatria Prof Dr Juan P Garrahan, Buenos Aires, DF, Argentina. [Cavazzana-Calvo, Marina] Hop Necker Enfants Malad, Biotherapy Dept, Paris, France. RI Brugman, Martijn/F-3389-2011; Notarangelo, Luigi/F-9718-2016 OI Brugman, Martijn/0000-0003-2675-2705; Notarangelo, Luigi/0000-0002-8335-0262 NR 0 TC 2 Z9 2 U1 0 U2 7 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 80 EP 81 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100165 ER PT J AU Marklin, M Bugl, S Bechtel, M Poljak, A Kopp, HG Kanz, L Rao, A Wirths, S Muller, MR AF Marklin, Melanie Bugl, Stefanie Bechtel, Marina Poljak, Alexandra Kopp, Hans-Georg Kanz, Lothar Rao, Anjana Wirths, Stefan Mueller, Martin R. TI Ca2+/NFAT Signaling Regulates the Expression CD38 and ZAP70 in Murine B Cells and Controls B1a Cell Homeostasis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Marklin, Melanie; Bugl, Stefanie; Bechtel, Marina; Poljak, Alexandra; Kopp, Hans-Georg; Kanz, Lothar; Wirths, Stefan; Mueller, Martin R.] Univ Tubingen, Dept Hematol Oncol & Immunol, Tubingen, Germany. [Rao, Anjana] Harvard Univ, Sch Med, Dept Pathol, Immune Dis Inst, Boston, MA 02115 USA. [Rao, Anjana] Program Cellular & Mol Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 88 EP 88 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100184 ER PT J AU Lewis, KB Nguyen, PC Schuman, JT Walsh, CE Josephson, NC Howard, TE Matthews, DC Key, NS Pratt, KP AF Lewis, Kenneth B. Phuong-Cac Nguyen Schuman, Jason T. Walsh, Christopher E. Josephson, Neil C. Howard, Tom E. Matthews, Dana C. Key, Nigel S. Pratt, Kathleen P. TI Determination of Anti-Factor VIIII Antibody Titers, Isotypes and Epitopes by SPR Analysis of Human Plasma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lewis, Kenneth B.; Phuong-Cac Nguyen; Josephson, Neil C.; Pratt, Kathleen P.] Puget Sound Blood Ctr, Res Inst, Seattle, WA 98104 USA. [Schuman, Jason T.] GE Healthcare, Life Sci, Piscataway, NJ USA. [Walsh, Christopher E.] Mt Sinai Sch Med, New York, NY USA. [Howard, Tom E.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Matthews, Dana C.] Seattle Childrens Hosp, Seattle, WA USA. [Key, Nigel S.] Univ N Carolina, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 94 EP 95 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100203 ER PT J AU Krause, DS Fulzele, K Barry, K Lotinun, S Baron, R Bonewald, L Feng, JQ Chen, M Weinstein, LS Bouxsein, M Scadden, DT Divieti-Pajevic, P AF Krause, Daniela S. Fulzele, Keertik Barry, Kevin Lotinun, Sutada Baron, Roland Bonewald, Lynda Feng, Jian Q. Chen, Min Weinstein, Lee S. Bouxsein, Mary Scadden, David T. Divieti-Pajevic, Paola TI Osteocytes Support Hematopoiesis by Altering the Bone Marrow Microenvironment Through Gs alpha Signaling SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Krause, Daniela S.] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA. [Fulzele, Keertik; Barry, Kevin; Divieti-Pajevic, Paola] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA. [Lotinun, Sutada; Baron, Roland] Harvard Univ, Sch Dent Med, Boston, MA 02115 USA. [Bonewald, Lynda] Univ Missouri, Dept Oral Biol, Kansas City, MO 64110 USA. [Feng, Jian Q.] Baylor Coll Dent, Texas A&M Hlth Sci Ctr, Dept Biomed Sci, Dallas, TX 75246 USA. [Chen, Min; Weinstein, Lee S.] NIDDK, Metab Dis Branch, NIH, Bethesda, MD USA. [Bouxsein, Mary] Beth Israel Deaconess Med Ctr, Ctr Adv Orthoped Studies, Boston, MA 02215 USA. [Bouxsein, Mary] Harvard Univ, Sch Med, Boston, MA USA. [Scadden, David T.] Harvard Univ, Ctr Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 101 EP 101 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100220 ER PT J AU Vo, TTT Stone, R DeAngelo, DJ Frattini, MG Letai, AG AF Vo, Thanh-Trang T. Stone, Richard DeAngelo, Daniel J. Frattini, Mark G. Letai, Anthony G. TI Measuring Mitochondrial Apoptotic Priming by BH3 Profiling Predicts Induction Outcome for Acute Myeloid Leukemia Patients SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Letai, Anthony G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Frattini, Mark G.] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10021 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 109 EP 109 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100240 ER PT J AU Wayne, AS Bhojwani, D Silverman, LB Richards, K Stetler-Stevenson, M Shah, NN Jeha, S Pui, CH Buzoianu, M FitzGerald, DJ Kreitman, RJ Ibrahim, R Pastan, I AF Wayne, Alan S. Bhojwani, Deepa Silverman, Lewis B. Richards, Kelly Stetler-Stevenson, Maryalice Shah, Nirali N. Jeha, Sima Pui, Ching-Hon Buzoianu, Manuela FitzGerald, David J. Kreitman, Robert J. Ibrahim, Ramy Pastan, Ira TI A Novel Anti-CD22 Immunotoxin, Moxetumomab Pasudotox: Phase I Study in Pediatric Acute Lymphoblastic Leukemia (ALL) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Wayne, Alan S.; Richards, Kelly; Shah, Nirali N.] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Bhojwani, Deepa; Jeha, Sima; Pui, Ching-Hon] St Jude Childrens Hosp, Memphis, TN 38105 USA. [Silverman, Lewis B.] Childrens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. [Stetler-Stevenson, Maryalice] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. [Buzoianu, Manuela; Ibrahim, Ramy] MedImmune LLC, Gaithersburg, MD USA. [Pastan, Ira] NCI, Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. NR 0 TC 10 Z9 9 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 113 EP 113 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100249 ER PT J AU Powell, BL Moser, BK Stock, W Gallagher, RE Willman, CL Stone, RM Rowe, JM Coutre, SE Feusner, JH Gregory, J Couban, S Appelbaum, FR Tallman, MS Larson, RA AF Powell, Bayard L. Moser, Barry K. Stock, Wendy Gallagher, Robert E. Willman, Cheryl L. Stone, Richard M. Rowe, Jacob M. Coutre, Steven E. Feusner, James H. Gregory, John Couban, Stephen Appelbaum, Frederick R. Tallman, Martin S. Larson, Richard A. TI Adding Mercaptopurine and Methotrexate to Alternate Week ATRA Maintenance Therapy Does Not Improve the Outcome for Adults with Acute Promyelocytic Leukemia (APL) in First Remission: Results From North American Leukemia Intergroup Trial C9710 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Powell, Bayard L.] Wake Forest Univ, Ctr Comprehens Canc, Winston Salem, NC 27109 USA. [Moser, Barry K.] Duke Univ, CALGB Stat Ctr, Durham, NC USA. [Stock, Wendy; Larson, Richard A.] Univ Chicago, Ctr Comprehens Canc, Chicago, IL 60637 USA. [Gallagher, Robert E.] Albert Einstein Coll Med, Bronx, NY 10467 USA. [Willman, Cheryl L.] Univ New Mexico, Ctr Canc, Albuquerque, NM 87131 USA. [Stone, Richard M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Rowe, Jacob M.] Technion Israel Inst Technol, Rambam Med Ctr, Haifa, Israel. [Coutre, Steven E.] Stanford Univ, Sch Med, Div Hematol, Stanford, CA 94305 USA. [Coutre, Steven E.] Stanford Univ, Sch Med, Div Oncol, Stanford, CA 94305 USA. [Coutre, Steven E.] Stanford Univ, Sch Med, Stanford Canc Ctr, Stanford, CA 94305 USA. [Feusner, James H.] Childrens Hosp & Res Ctr, Oakland, CA USA. [Gregory, John] Goryeb Childrens Hosp, Atlantic Hlth Syst, Morristown, NJ USA. [Couban, Stephen] Dalhousie Univ, Halifax, NS, Canada. [Appelbaum, Frederick R.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Tallman, Martin S.] Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY 10021 USA. NR 0 TC 7 Z9 7 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 118 EP 119 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100259 ER PT J AU Lohr, J Stojanov, P Lawrence, MS Auclair, D Chapuy, B Carter, S Sougnez, C Gould, J Cruz-Gordillo, P Cerhan, JR Dogan, A Habermann, TM Link, BK Rangel-Escareno, C Hernadez-Lemus, E Hidalgo-Miranda, A Melendez-Zajgla, J Fernandez-Lopez, JC Imaz, I Schwarz, A Shipp, MA Getz, G Golub, TR AF Lohr, Jens Stojanov, Petar Lawrence, Michael S. Auclair, Daniel Chapuy, Bjoern Carter, Scott Sougnez, Carrie Gould, Joshua Cruz-Gordillo, Peter Cerhan, James R. Dogan, Ahmet Habermann, Thomas M. Link, Brian K. Rangel-Escareno, Claudia Hernadez-Lemus, Enrique Hidalgo-Miranda, Alfredo Melendez-Zajgla, Jorge Fernandez-Lopez, Juan Carlos Imaz, Ivan Schwarz, Angela Shipp, Margaret A. Getz, Gad Golub, Todd R. TI The Mutational Landscape of Diffuse Large B Cell Lymphoma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lohr, Jens] DFCI, Boston, MA USA. [Chapuy, Bjoern; Shipp, Margaret A.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Cerhan, James R.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Dogan, Ahmet] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. [Habermann, Thomas M.] Mayo Clin, Div Hematol, Rochester, MN USA. [Link, Brian K.] Univ Iowa, Holden Comprehens Canc Ctr, Iowa City, IA USA. [Rangel-Escareno, Claudia; Hernadez-Lemus, Enrique; Hidalgo-Miranda, Alfredo; Melendez-Zajgla, Jorge; Fernandez-Lopez, Juan Carlos; Imaz, Ivan; Schwarz, Angela] Inst Nacl Med Genom, Mexico City, DF, Mexico. [Golub, Todd R.] Harvard Univ, Broad Inst, Canc Program, Cambridge, MA 02138 USA. [Golub, Todd R.] MIT, Cambridge, MA 02139 USA. RI Hidalgo-Miranda, Alfredo/B-2123-2010; Rangel-Escareno, Claudia/F-4587-2012 OI Hidalgo-Miranda, Alfredo/0000-0003-2315-3977; Rangel-Escareno, Claudia/0000-0003-1303-0834 NR 0 TC 0 Z9 0 U1 1 U2 5 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 119 EP 119 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100260 ER PT J AU Xu, L Sohani, AR Arcaini, L Hunter, Z Yang, G Zhou, YS Liu, X Cao, Y Manning, R Patterson, CJ Ioakimidis, L Tripsas, C Pinkus, GS Harris, NL Rodig, SJ Treon, S AF Xu, Lian Sohani, Aliyah R. Arcaini, Luca Hunter, Zachary Yang, Guang Zhou, Yangsheng Liu, Xia Cao, Yang Manning, Robert Patterson, Christopher J. Ioakimidis, Leukothea Tripsas, Christina Pinkus, Geraldine S. Harris, Nancy Lee Rodig, Scott J. Treon, Steven TI A Somatic Variant in MYD88 (L265P) Revealed by Whole Genome Sequencing Differentiates Lymphoplasmacytic Lymphoma From Marginal Zone Lymphomas SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Xu, Lian; Hunter, Zachary; Yang, Guang; Zhou, Yangsheng; Liu, Xia; Cao, Yang; Manning, Robert; Ioakimidis, Leukothea; Tripsas, Christina] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Sohani, Aliyah R.] Maasachusetts Gen Hosp, Boston, MA USA. [Arcaini, Luca] Univ Pavia, Div Hematol, I-27100 Pavia, Italy. [Patterson, Christopher J.] Dana Farber Canc Inst, Waldenstroms Macroglobulinemia Ctr, Boston, MA 02115 USA. [Pinkus, Geraldine S.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Harris, Nancy Lee] Massachusetts Gen Hosp, Waban, MA USA. [Rodig, Scott J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Treon, Steven] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 1 Z9 1 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 120 EP 120 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100262 ER PT J AU Komrokji, RS Wadleigh, M Seymour, JF Roberts, AW To, LB Zhu, HJ Mesa, RA AF Komrokji, Rami S. Wadleigh, Martha Seymour, John F. Roberts, Andrew W. To, Luen Bik Zhu, Huan J. Mesa, Ruben A. TI Results of a Phase 2 Study of Pacritinib (SB1518), a Novel Oral JAK2 Inhibitor, In Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Komrokji, Rami S.] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. [Wadleigh, Martha] Dana Farber Canc Inst, Boston, MA 02115 USA. [Seymour, John F.] Peter MacCallum Canc Inst, Dept Haematol Tumour Stream, Melbourne, Vic, Australia. [Roberts, Andrew W.] Royal Melbourne Hosp, Dept Clin Haematol & Med Oncol, Parkville, Vic 3050, Australia. [To, Luen Bik] IMVS, Dept Haematol, Adelaide, SA, Australia. [Zhu, Huan J.] SBIO Inc, Global Clin Dev, Redwood City, CA USA. [Mesa, Ruben A.] Mayo Clin, Div Hematol & Med Oncol, Scottsdale, AZ USA. NR 0 TC 9 Z9 9 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 130 EP 131 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100283 ER PT J AU Landau, DA Stojanov, P Lawrence, MS Sougnez, C McKeena, A Carter, S Gabriel, S Neuberg, D Hacohen, N Lander, ES Brown, JR Getz, G Wu, C AF Landau, Dan-Avi Stojanov, Petar Lawrence, Michael S. Sougnez, Carrie McKeena, Aaron Carter, Scott Gabriel, Stacey Neuberg, Donna Hacohen, Nir Lander, Eric S. Brown, Jennifer R. Getz, Gad Wu, Cathy TI Shifts in Intra-Clonal Dynamics Rather Than Novel Mutations Are the Main Engine Driving Tumor Evolution in Relapsed CLL SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Landau, Dan-Avi; Stojanov, Petar; Lawrence, Michael S.; Sougnez, Carrie; McKeena, Aaron; Carter, Scott; Gabriel, Stacey; Hacohen, Nir; Lander, Eric S.; Getz, Gad] Broad Inst, Cambridge, MA USA. [Neuberg, Donna; Brown, Jennifer R.; Wu, Cathy] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 131 EP 132 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100285 ER PT J AU Kaufman, M Yan, XJ Ghia, EM Neuberg, D Rassenti, LZ Stamatopoulos, K Ghia, P Oscier, DG Davi, F Rosenquist, R Belessi, C Davis, Z Agathangelidis, A Kay, N Byrd, JC Brown, JR Rai, KR Kipps, TJ Chiorazzi, N AF Kaufman, Matthew Yan, Xiao J. Ghia, Emanuela M. Neuberg, Donna Rassenti, Laura Z. Stamatopoulos, Kostas Ghia, Paolo Oscier, David G. Davi, Frederic Rosenquist, Richard Belessi, Chrysoula Davis, Zadie Agathangelidis, Andreas Kay, Neil Byrd, John C. Brown, Jennifer R. Rai, Kanti R. Kipps, Thomas J. Chiorazzi, Nicholas TI Chronic Lymphocytic Leukemia Patients with IGHV Genes Carrying Only Silent Mutations Have A Longer Time From Diagnosis to Initial Therapy Than Patients Expressing B-Cell Receptors with No Somatic Mutations SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kaufman, Matthew] Long Isl Jewish Med Ctr, New Hyde Pk, NY 11042 USA. [Yan, Xiao J.] Feinstein Inst Med Res, Manhasset, NY USA. [Ghia, Emanuela M.; Rassenti, Laura Z.] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 92093 USA. [Brown, Jennifer R.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Stamatopoulos, Kostas] G Papanicolaou Hosp, Thessaloniki, Greece. [Ghia, Paolo] Univ Vita Salute San Raffaele, Div Mol Oncol, Milan, Italy. [Ghia, Paolo] Univ Vita Salute San Raffaele, Dept Oncohematol, Milan, Italy. [Ghia, Paolo] Ist Sci San Raffaele, Milan, Italy. [Davi, Frederic] Hop La Pitie Salpetriere, APHP, Serv Hematol Biol, Paris, France. [Oscier, David G.] Royal Bournemouth Hosp, Dept Hematol, Bournemouth, Dorset, England. [Rosenquist, Richard] Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden. [Rosenquist, Richard] Uppsala Univ, Rudbeck Lab, Uppsala, Sweden. [Belessi, Chrysoula] Nikea Gen Hosp, Dept Hematol, Piraeus, Greece. [Davis, Zadie] Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England. [Agathangelidis, Andreas] Inst Agrobiotechnol, Thessaloniki, Greece. [Kay, Neil] Mayo Clin, Div Hematol, Rochester, MN USA. [Byrd, John C.] Ohio State Univ, Div Hematol, Columbus, OH 43210 USA. [Rai, Kanti R.] N Shore Long Isl Jewish Hlth Syst, Dept Med, New Hyde Pk, NY USA. [Chiorazzi, Nicholas] N Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Manhasset, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 133 EP 134 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100289 ER PT J AU James, DF Brown, JR Werner, L Wierda, WG Barrientos, JC Castro, J Greaves, A Rassenti, LZ Rai, KR Neuberg, D Kipps, TJ AF James, Danelle F. Brown, Jennifer R. Werner, Lillian Wierda, William G. Barrientos, Jaqueline C. Castro, Januario Greaves, Andrew Rassenti, Laura Z. Rai, Kanti R. Neuberg, Donna Kipps, Thomas J. TI Lenalidomide and Rituximab for the Initial Treatment of Patients with Chronic Lymphocytic Leukemia (CLL) A Multicenter Study of the CLL Research Consortium SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [James, Danelle F.] Univ Calif San Diego, Div Hematol & Oncol, Moores UCSD Canc Ctr, San Diego, CA 92103 USA. [James, Danelle F.; Castro, Januario] UCSD, La Jolla, CA USA. [Brown, Jennifer R.; Werner, Lillian; Neuberg, Donna] Dana Farber Canc Inst, Boston, MA 02115 USA. [Wierda, William G.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Barrientos, Jaqueline C.] Noth Shore Long Isl JEwish Hlth Syst, New Hyde Pk, NY USA. [Greaves, Andrew] UCSD Moores Canc Ctr, Moores Canc Ctr, La Jolla, CA USA. [Rassenti, Laura Z.] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 92093 USA. [Rai, Kanti R.] N Shore Long Isl Jewish Hlth Syst, Dept Med, New Hyde Pk, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 135 EP 135 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100292 ER PT J AU Munshi, NC Avet-Loiseau, H Stephens, PJ Bignell, GR Tai, YT Shammas, M Li, C Shah, PK Fulciniti, M Pal, J Vahia, AV Richardson, PG Minvielle, S Campbell, P Anderson, KC Futreal, A AF Munshi, Nikhil C. Avet-Loiseau, Herve Stephens, Philip J. Bignell, Graham R. Tai, Yu-Tzu Shammas, Masood Li, Cheng Shah, Parantu K. Fulciniti, Mariateresa Pal, Jagannath Vahia, Ankit V. Richardson, Paul G. Minvielle, Stephane Campbell, Peter Anderson, Kenneth C. Futreal, Andrew TI Whole Genome Sequencing Defines the Clonal Architecture and Genomic Evolution in Myeloma: Tumor Heterogeneity with Continued Acquisition of New Mutational Change SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Munshi, Nikhil C.] VA Boston Healthcare Syst, Hematol, Boston, MA USA. [Avet-Loiseau, Herve] CHU Nantes, F-44035 Nantes 01, France. [Campbell, Peter] Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge, England. [Tai, Yu-Tzu; Fulciniti, Mariateresa; Richardson, Paul G.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. RI Minvielle, Stephane/K-8251-2015 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 138 EP 139 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100298 ER PT J AU Treon, SP Xu, L Zhou, YS Liu, X Yang, G Cao, Y Hanzis, C Sheehy, P Manning, R Patterson, CJ Laramie, JM Skifter, DA Lincoln, SE Hunter, Z AF Treon, Steven P. Xu, Lian Zhou, Yangsheng Liu, Xia Yang, Guang Cao, Yang Hanzis, Christina Sheehy, Patricia Manning, Robert Patterson, Christopher J. Laramie, Jason M. Skifter, Donald. A. Lincoln, Stephen E. Hunter, Zachary TI Whole Genome Sequencing Reveals a Widely Expressed Mutation (MYD88 L265P) with Oncogenic Activity in Waldenstrom's Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Treon, Steven P.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Xu, Lian; Zhou, Yangsheng; Liu, Xia; Yang, Guang; Cao, Yang; Hanzis, Christina; Sheehy, Patricia; Manning, Robert; Hunter, Zachary] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Patterson, Christopher J.] Dana Farber Canc Inst, Waldenstroms Macroglubulinemia Ctr, Boston, MA 02115 USA. [Laramie, Jason M.; Skifter, Donald. A.; Lincoln, Stephen E.] Complete Genom, Mountain View, CA USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 140 EP 140 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100301 ER PT J AU Lonial, S Jakubowiak, AJ Jagannath, S Raab, MS Facon, T Vij, R Moreau, P Reece, DE White, DJ Benboubker, L Zonder, JA Rossi, JF Tsao, C Parli, T Kroog, G Singhal, AK Richardson, PG AF Lonial, Sagar Jakubowiak, Andrzej J. Jagannath, Sundar Raab, Marc S. Facon, Thierry Vij, Ravi Moreau, Philippe Reece, Donna E. White, Darrell J. Benboubker, Lotfi Zonder, Jeffrey A. Rossi, Jean-Francois Tsao, Claire Parli, Teresa Kroog, Glenn Singhal, Anil K. Richardson, Paul G. TI A Phase 2 Study of Elotuzumab in Combination with Lenalidomide and Low-Dose Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. [Jakubowiak, Andrzej J.] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA. [Jagannath, Sundar] Mt Sinai Med Ctr, Multiple Myeloma Program, New York, NY 10029 USA. [Raab, Marc S.] Univ Klinikum Heildelberg, Heidelberg, Germany. [Facon, Thierry] Ctr Hosp Reg & Univ Lille, Hop Huriez, Serv Malad Sang, CHRU, F-59037 Lille, France. [Vij, Ravi] Washington Univ, Sch Med, Div Oncol, St Louis, MO USA. [Moreau, Philippe] CHU Nantes, Hematol Dept, F-44035 Nantes 01, France. [Reece, Donna E.] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada. [White, Darrell J.] Queen Elizabeth 2 Hlth Sci Ctr, Div Hematol, Halifax, NS, Canada. [Benboubker, Lotfi] CHU Tours Hop Bretonneau, Serv Hematol, Tours, France. [Zonder, Jeffrey A.] Karmanos Canc Inst, Myeloma Program, Detroit, MI USA. [Rossi, Jean-Francois] Chu Montpellier Hop St Eloi, Serv Hematol Clin & Biotherapies, Montpellier, France. [Tsao, Claire; Parli, Teresa] Abbott Pharmaceut, Abbott Pk, IL USA. [Kroog, Glenn] Bristol Myers Squibb, Plainsboro, NJ USA. [Singhal, Anil K.] Abbott Labs, Abbott Pk, IL 60064 USA. [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. RI FACON, THIERRY/M-9736-2014; richard, chrystelle/K-8595-2015 OI FACON, THIERRY/0000-0001-7705-8460; NR 0 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 141 EP 142 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100304 ER PT J AU Jagannath, S Chanan-Khan, A Heffner, LT Avigan, D Zimmerman, TM Lonial, S Lutz, RJ Engling, A Uherek, C Osterroth, F Ruehle, M Beelitz, MA Niemann, G Wartenberg-Demand, A Haeder, T Anderson, KC Munshi, NC AF Jagannath, Sundar Chanan-Khan, Asher Heffner, Leonard T. Avigan, David Zimmerman, Todd M. Lonial, Sagar Lutz, Robert J. Engling, Andre Uherek, Christoph Osterroth, Frank Ruehle, Markus Beelitz, Michelle A. Niemann, Gabriele Wartenberg-Demand, Andrea Haeder, Thomas Anderson, Kenneth C. Munshi, Nikhil C. TI BT062, An Antibody-Drug Conjugate Directed Against CD138, Shows Clinical Activity in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Jagannath, Sundar] Mt Sinai Med Ctr, Multiple Myeloma Program, New York, NY 10029 USA. [Chanan-Khan, Asher] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. [Avigan, David] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Zimmerman, Todd M.] Univ Chicago, Dept Med, Chicago, IL 60637 USA. [Lutz, Robert J.] ImmunoGen Inc, Translat Res & Dev, Waltham, MA USA. [Engling, Andre; Uherek, Christoph; Osterroth, Frank] Biotest AG, GBU Biotherapeut, Dreieich, Germany. [Ruehle, Markus] Biotest AG, Corp Drug Safety, Dreieich, Germany. [Beelitz, Michelle A.] Biotest Pharmaceut Corp, Clin Res, Boca Raton, FL USA. [Niemann, Gabriele; Wartenberg-Demand, Andrea; Haeder, Thomas] Biotest AG, Corp Clin Res, Dreieich, Germany. [Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 142 EP 143 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100306 ER PT J AU Lentzsch, S O'Sullivan, A Kennedy, R Abbas, M Gill, N Dai, L Andreas, C Gardner, D Pregja, SL Burt, S Redner, RL Volkin, R Roodman, GD Mapara, MY Viverette, JF Agha, M Waas, JK Shuai, YL Normolle, D Zonder, JA AF Lentzsch, Suzanne O'Sullivan, Amy Kennedy, Ryan Abbas, Mohammad Gill, Navkiranjit Dai, Lijun Andreas, Carrie Gardner, Diane Pregja, Silvana Lalo Burt, Steve Redner, Robert L. Volkin, Robert Roodman, G. David Mapara, Markus Y. Viverette, J. Franklin Agha, Mounzer Waas, John K. Shuai, Yongli Normolle, Daniel Zonder, Jeffrey A. TI Combination of Bendamustine, Lenalidomide, and Dexamethasone (BLD) in Patients with Refractory or Relapsed Multiple Myeloma Is Safe and Highly Effective: Results of Phase I/II Open-Label, Dose Escalation Study SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lentzsch, Suzanne; O'Sullivan, Amy; Kennedy, Ryan; Abbas, Mohammad; Gill, Navkiranjit; Dai, Lijun; Andreas, Carrie; Gardner, Diane; Redner, Robert L.; Mapara, Markus Y.] Univ Pittsburgh, Sch Med, Dept Med, Div Hematol Oncol, Pittsburgh, PA USA. [Lentzsch, Suzanne; O'Sullivan, Amy; Kennedy, Ryan; Abbas, Mohammad; Gill, Navkiranjit; Dai, Lijun; Andreas, Carrie; Gardner, Diane; Redner, Robert L.; Mapara, Markus Y.] Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA. [Pregja, Silvana Lalo; Burt, Steve; Zonder, Jeffrey A.] Barbara Ann Karmanos Canc Inst, MYELOMA PROGRAM, Detroit, MI USA. [Volkin, Robert; Agha, Mounzer] UPMC Canc Ctr, Pittsburgh, PA USA. [Roodman, G. David] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Viverette, J. Franklin; Waas, John K.] UPMC Canc Ctr, Greensburg, PA USA. [Shuai, Yongli; Normolle, Daniel] Univ Pittsburgh, Inst Canc, Biostat Facil, Pittsburgh, PA USA. RI mapara, markus/A-2134-2013 NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 142 EP 142 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100305 ER PT J AU Srinivasan, M Flynn, R Price, A Ranger, A Browning, JL Taylor, PA Ritz, J Antin, JH Murphy, WJ Luznik, L Shlomchik, M Panoskaltsis-Mortari, A Blazar, BR AF Srinivasan, Mathangi Flynn, Ryan Price, Andrew Ranger, Ann Browning, Jeffrey L. Taylor, Patricia A. Ritz, Jerome Antin, Joseph H. Murphy, William J. Luznik, Leo Shlomchik, Mark Panoskaltsis-Mortari, Angela Blazar, Bruce R. TI Donor B-Cell Alloantibody Deposition and Germinal Center Formation Are Required for the Development of Murine Chronic Gvhd and Bronchiotitis Obliterans SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Srinivasan, Mathangi; Flynn, Ryan; Price, Andrew] Univ MN, Div Blood & Marrow Transplantat, Masonic Canc Ctr, Minneapolis, MN USA. [Ranger, Ann; Browning, Jeffrey L.] Biogen Idec Inc, Cambridge, MA 02142 USA. [Taylor, Patricia A.; Panoskaltsis-Mortari, Angela] Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Masonic Canc Ctr, Minneapolis, MN 55455 USA. [Antin, Joseph H.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Murphy, William J.] UNR, Reno, NV USA. [Luznik, Leo] Johns Hopkins Univ, Baltimore, MD USA. [Shlomchik, Mark] Yale New Haven Med Ctr, Dept Immunobiol & Lab Med, New Haven, CT 06504 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 143 EP 144 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100308 ER PT J AU Mielcarek, M Storer, B Martin, PJ Negrin, RS Forman, SJ Flowers, MED Inamoto, Y Chauncey, T Storb, R Appelbaum, FR Bensinger, WI AF Mielcarek, Marco Storer, Barry Martin, Paul J. Negrin, Robert S. Forman, Stephen J. Flowers, Mary E. D. Inamoto, Yoshihiro Chauncey, Thomas Storb, Rainer Appelbaum, Frederick R. Bensinger, William I. TI Transplantation of Peripheral Blood Cells As Compared with Bone Marrow From HLA-Identical Related Donors Is Associated with Superior Long-Term Outcomes SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Mielcarek, Marco; Storer, Barry; Martin, Paul J.; Inamoto, Yoshihiro; Appelbaum, Frederick R.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Negrin, Robert S.] Stanford Univ, Stanford, CA 94305 USA. [Forman, Stephen J.] City Hope Natl Med Ctr, Beckman Res Inst, Dept Hematol & Hematopoiet Cell Transplantat, Dept Canc Immunotherapeut & Tumor Immunol, Duarte, CA 91010 USA. [Flowers, Mary E. D.; Storb, Rainer; Bensinger, William I.] Univ Washington, Seattle, WA 98195 USA. [Chauncey, Thomas] VA Puget Sound Hlth Care Syst, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 149 EP 149 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100320 ER PT J AU Armand, P Gibson, CJ Cutler, C Ho, VT Koreth, J Alyea, EP Antin, JH Soiffer, RJ Kim, HT AF Armand, Philippe Gibson, Christopher J. Cutler, Corey Ho, Vincent T. Koreth, John Alyea, Edwin P., III Antin, Joseph H. Soiffer, Robert J. Kim, Haesook T. TI A Disease and Stage Risk Grouping System for Patients Undergoing Allogeneic Stem Cell Transplantation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Armand, Philippe; Gibson, Christopher J.; Cutler, Corey; Ho, Vincent T.; Koreth, John; Alyea, Edwin P., III; Antin, Joseph H.; Soiffer, Robert J.; Kim, Haesook T.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 153 EP 154 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100328 ER PT J AU Shah, DI Takahashi-Makise, N Cooney, JD Li, LT Schultz, I Pierce, EL Narla, A Hattangadi, S Langer, N Chen, W Dailey, TA Hurst, SN Faccenda, D Wiwczar, J Law, TC Vogin, G Brugnara, C Zhou, Y Ward, DM Ebert, BL Campanella, M Danial, N Lodish, HF Dailey, HA Kaplan, J Paw, BH AF Shah, Dhvanit I. Takahashi-Makise, Naoko Cooney, Jeffrey D. Li, Liangtao Schultz, Iman Pierce, Eric L. Narla, Anupama Hattangadi, Shilpa Langer, Nathanial Chen, Wen Dailey, Tamara A. Hurst, Slater N. Faccenda, Danilo Wiwczar, Jessica Law, Terrence C. Vogin, Guillaume Brugnara, Carlo Zhou, Yi Ward, Diane M. Ebert, Benjamin L. Campanella, Michelangelo Danial, Nika Lodish, Harvey F. Dailey, Harry A. Kaplan, Jerry Paw, Barry H. TI Mitochondrial Atpif1 Regulates Heme Synthesis in Developing Erythroblasts SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Shah, Dhvanit I.; Cooney, Jeffrey D.; Schultz, Iman; Pierce, Eric L.; Narla, Anupama; Langer, Nathanial; Chen, Wen; Hurst, Slater N.; Vogin, Guillaume; Ebert, Benjamin L.; Paw, Barry H.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Hematol,Dept Med, Boston, MA 02115 USA. [Takahashi-Makise, Naoko; Li, Liangtao] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA. [Hattangadi, Shilpa] Harvard Univ, Sch Med, Childrens Hosp Boston, Div Hematol Oncol, Boston, MA USA. [Dailey, Tamara A.; Dailey, Harry A.] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. [Dailey, Tamara A.; Dailey, Harry A.] Univ Georgia, Dept Biochem, Athens, GA 30602 USA. [Dailey, Tamara A.; Dailey, Harry A.] Univ Georgia, Dept Mol Biol, Athens, GA 30602 USA. [Faccenda, Danilo] Univ London, Dept Pharmacol, London WC1N 1AX, England. [Wiwczar, Jessica] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. [Brugnara, Carlo] Harvard Univ, Sch Med, Childrens Hosp Boston, Dept Pathol, Boston, MA 02115 USA. [Lodish, Harvey F.] MIT, Whitehead Inst Biomed Res, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 161 EP 162 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100344 ER PT J AU Xu, J Peng, C Sankaran, VG Orkin, SH AF Xu, Jian Peng, Cong Sankaran, Vijay G. Orkin, Stuart H. TI Correction of Murine Sickle Cell Disease Through Interference with Fetal Hemoglobin Silencing SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Xu, Jian; Peng, Cong; Sankaran, Vijay G.] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA. [Orkin, Stuart H.] Harvard Univ, Sch Med, Dana Farber Canc Inst,Howard Hughes Med Inst, Dept Pediat Oncol,Harvard Stem Cell Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 165 EP 165 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100352 ER PT J AU Esrick, EB Xu, J Lin, K McConkey, ME Frisbee, A Poveromo, L Orkin, SH Bradner, JE Ebert, BL AF Esrick, Erica B. Xu, Jian Lin, Katherine McConkey, Marie Ellen Frisbee, Alyse Poveromo, Luke Orkin, Stuart H. Bradner, James E. Ebert, Benjamin L. TI Induction of Fetal Hemoglobin by Inactivation of HDAC1 or HDAC2 without Altering Cellular Proliferation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Esrick, Erica B.] Childrens Hosp, Boston, MA 02115 USA. [Xu, Jian] Howard Hughes Med Inst, Boston, MA 02115 USA. [Lin, Katherine; McConkey, Marie Ellen; Frisbee, Alyse; Poveromo, Luke; Ebert, Benjamin L.] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA. [Orkin, Stuart H.; Bradner, James E.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 166 EP 166 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100355 ER PT J AU Shi, JL Nikova, DN Gilbert, GE AF Shi, Jialan Nikova, Dessislava N. Gilbert, Gary E. TI Stressed Endothelial Cells Compartmentalize the Prothrombinase Complex on Filopodia and Other Convex Membrane Features near the Cell Margin SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Shi, Jialan; Gilbert, Gary E.] Harvard Univ, Sch Med, Dept Med, VA Boston Healthcare Syst,Brigham & Womens Hosp, Boston, MA USA. [Nikova, Dessislava N.] Harvard Univ, Sch Med, W Roxbury, MA USA. [Nikova, Dessislava N.] VA Boston Healthcare Syst, Res, W Roxbury, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 173 EP 173 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100373 ER PT J AU Kalaitzidis, D Sykes, SM Punt, N Tang, YF Lane, SW Clish, C Gilliland, DG Scadden, DT Guertin, D Armstrong, SA AF Kalaitzidis, Demetrios Sykes, Stephen M. Punt, Natalie Tang, Yuefeng Lane, Steven W. Clish, Clary Gilliland, D. Gary Scadden, David T. Guertin, David Armstrong, Scott A. TI Mtor Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Punt, Natalie] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA. [Sykes, Stephen M.; Scadden, David T.] Harvard Univ, Massachusetts Gen Hosp, Ctr Regenerat Med, Dept Stem Cell & Regenerat Biol, Boston, MA 02115 USA. [Sykes, Stephen M.; Scadden, David T.] Harvard Stem Cell Inst, Boston, MA USA. [Punt, Natalie; Armstrong, Scott A.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Tang, Yuefeng; Guertin, David] Univ Massachusetts, Sch Med, Worcester, MA USA. [Lane, Steven W.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Clish, Clary] Broad Inst MIT & Harvard, Boston, MA USA. [Gilliland, D. Gary] Merck Res Labs, Boston, MA USA. RI Tang, Yuefeng/J-9770-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 180 EP 180 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100392 ER PT J AU Abdel-Wahab, O Adli, M Saunders, L Gao, J Shih, AH Pandey, S Jaffe, J Zhao, XY Perna, F Carroll, M Melnick, A Nimer, SD Aifantis, I Bernstein, B Levine, RL AF Abdel-Wahab, Omar Adli, Mazhar Saunders, Lindsay Gao, Jie Shih, Alan H. Pandey, Suveg Jaffe, Jake Zhao, Xinyang Perna, Fabiana Carroll, Martin Melnick, Ari Nimer, Stephen D. Aifantis, Iannis Bernstein, Bradley Levine, Ross L. TI ASXL1 Mutations Promote Myeloid Transformation Through Inhibition of PRC2-Mediated Gene Repression SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Abdel-Wahab, Omar; Saunders, Lindsay; Levine, Ross L.] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA. [Shih, Alan H.] Mem Sloan Kettering Canc Ctr, Leukemia Serv, Dept Med, New York, NY 10021 USA. [Adli, Mazhar; Jaffe, Jake] Broad Inst Harvard & MIT, Cambridge, MA USA. [Adli, Mazhar] Massachusetts Gen Hosp, Howard Hughes Med Inst, Dept Pathol, Cambridge, MA USA. [Adli, Mazhar] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. [Gao, Jie] NYU, Sch Med, New York, NY USA. [Zhao, Xinyang] Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10021 USA. [Carroll, Martin] Univ Penn, Div Hematol & Oncol, Philadelphia, PA 19104 USA. [Melnick, Ari] Weill Cornell Med Coll, New York, NY USA. [Bernstein, Bradley] Massachusetts Gen Hosp, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 185 EP 186 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100406 ER PT J AU Scott, DW Chan, FC Hong, FX Rogic, S Tan, K Meissner, B Farinha, P Horning, SJ Fisher, RI Bartlett, NL Shepherd, LE Connors, JM de Sousa, AB Kahl, BS Gordon, LI Steidl, C Gascoyne, RD AF Scott, David W. Chan, Fong Chun Hong, Fangxin Rogic, Sanja Tan, King Meissner, Barbara Farinha, Pedro Horning, Sandra J. Fisher, Richard I. Bartlett, Nancy L. Shepherd, Lois E. Connors, Joseph M. de Sousa, Aida B. Kahl, Brad S. Gordon, Leo I. Steidl, Christian Gascoyne, Randy D. TI A Gene. Expression Signature in Diagnostic Formalin Fixed Paraffin Embedded Tissue Predicts Overall Survival in Locally Advanced and Advanced Stage Classical Hodgkin Lymphoma - a Correlative Study From the E2496 Intergroup Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Scott, David W.; Chan, Fong Chun; Rogic, Sanja; Tan, King; Meissner, Barbara; Farinha, Pedro; Connors, Joseph M.; Steidl, Christian; Gascoyne, Randy D.] British Columbia Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC V5Z 4E6, Canada. [Hong, Fangxin] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Horning, Sandra J.] Genentech Inc, Clin Dev Hem Onc, San Francisco, CA 94080 USA. [Fisher, Richard I.] Univ Rochester, James P Wilmot Canc Ctr, Rochester, NY USA. [Bartlett, Nancy L.] Washington Univ, Sch Med, St Louis, MO USA. [Shepherd, Lois E.] Queens Univ, NCIC Clin Trials Grp, Kingston, ON, Canada. [de Sousa, Aida B.] Ctr Hosp Lisboa Cent, Lisbon, Portugal. [Kahl, Brad S.] Univ Wisconsin, Dept Med Hematol Oncol, Madison, WI USA. [Gordon, Leo I.] Northwestern Univ, Div Hematol Oncol, Feinberg Sch Med, Chicago, IL 60611 USA. [Gordon, Leo I.] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 198 EP 199 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100431 ER PT J AU Hunter, Z Xu, L Zhou, YS Yang, G Liu, X Cao, Y Hanzis, C Sheehy, P Manning, R Patterson, CJ Laramie, JM Skifter, DA Lincoln, SE Treon, SP AF Hunter, Zachary Xu, Lian Zhou, Yangsheng Yang, Guang Liu, Xia Cao, Yang Hanzis, Christina Sheehy, Patricia Manning, Robert Patterson, Christopher J. Laramie, Jason M. Skifter, Donald A. Lincoln, Stephen E. Treon, Steven P. TI Whole-Genome Sequencing Results From 30 Patients with Waldenstrom's Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Hunter, Zachary; Xu, Lian; Zhou, Yangsheng; Yang, Guang; Liu, Xia; Cao, Yang; Hanzis, Christina; Sheehy, Patricia; Manning, Robert; Patterson, Christopher J.] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Laramie, Jason M.; Skifter, Donald A.; Lincoln, Stephen E.] Complete Genom, Mountain View, CA USA. [Treon, Steven P.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 200 EP 200 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100435 ER PT J AU Ottmann, OG DeAngelo, DJ Garcia-Manero, G Lubbert, M Jillella, A Sekeres, MA Zahlten, A Squier, M Acharyya, S Winiger, IJ Fenaux, P AF Ottmann, Oliver G. DeAngelo, Daniel J. Garcia-Manero, Guillermo Luebbert, Michael Jillella, Anand Sekeres, Mikkael A. Zahlten, Anita Squier, Margaret Acharyya, Suddhasatta Winiger, Ivo J. Fenaux, Pierre TI Determination of a Phase II Dose of Panobinostat in Combination with 5-Azacitidine in Patients with Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ottmann, Oliver G.] Goethe Univ Frankfurt, Dept Internal Med, Frankfurt, Germany. [DeAngelo, Daniel J.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Garcia-Manero, Guillermo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Luebbert, Michael] Univ Freiburg, D-79106 Freiburg, Germany. [Jillella, Anand] Georgia Hlth Sci Univ, Augusta, GA USA. [Sekeres, Mikkael A.] Cleveland Clin, Cleveland, OH 44106 USA. [Zahlten, Anita; Winiger, Ivo J.] Novartis Pharma AG, Basel, Switzerland. [Squier, Margaret; Acharyya, Suddhasatta] Novartis Pharmaceut, E Hanover, NJ USA. [Fenaux, Pierre] Hop Avicenne, AP HP, F-93009 Bobigny, France. RI Ottmann, Oliver/D-5007-2016 OI Ottmann, Oliver/0000-0001-9559-1330 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 212 EP 213 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100460 ER PT J AU Patnaik, MM Lasho, TL Hodnefield, JM Knudson, RA Ketterling, RP Al-Kali, A Garcia-Manero, G Steensma, DP Pardanani, A Hanson, CA Tefferi, A AF Patnaik, Mrinal M. Lasho, Terra L. Hodnefield, Janice M. Knudson, Ryan A. Ketterling, Rhett P. Al-Kali, Aref Garcia-Manero, Guillermo Steensma, David P. Pardanani, Animesh Hanson, Curtis A. Tefferi, Ayalew TI SF3B1 Mutations Are Prevalent in Myelodysplastic Syndromes with Ring Sideroblasts but Do Not Hold Independent Prognostic Value SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Patnaik, Mrinal M.; Lasho, Terra L.; Al-Kali, Aref; Pardanani, Animesh; Tefferi, Ayalew] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA. [Hodnefield, Janice M.] Mayo Clin, Div Hematopathol, Rochester, MN USA. [Knudson, Ryan A.; Ketterling, Rhett P.] Mayo Clin, Dept Lab Med, Cytogenet Div, Rochester, MN USA. [Garcia-Manero, Guillermo] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA. [Steensma, David P.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 213 EP 213 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100461 ER PT J AU Wan, YZ Lawrence, MS Wang, LL Stojanov, P Sougnez, C Stevenson, K Werner, L Zhang, WD Folco, EG Tesar, B Sievers, QL Gabriel, S Hacohen, N Reed, R Meyerson, M Golub, TR Lander, ES Neuberg, D Brown, JR Getz, G Wu, CJ AF Wan, Youzhong Lawrence, Michael S. Wang, Lili Stojanov, Petar Sougnez, Carrie Stevenson, Kristen Werner, Lillian Zhang, Wandi Folco, Eric G. Tesar, Bethany Sievers, Quinlan L. Gabriel, Stacey Hacohen, Nir Reed, Robin Meyerson, Matthew Golub, Todd R. Lander, Eric S. Neuberg, Donna Brown, Jennifer R. Getz, Gad Wu, Catherine J. TI Large-Scale CLL Genome Analysis Reveals Novel Cancer Genes, Including SF3B1 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Wang, Lili] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Lawrence, Michael S.; Stojanov, Petar; Sougnez, Carrie; Gabriel, Stacey; Hacohen, Nir; Golub, Todd R.; Lander, Eric S.; Getz, Gad] Broad Inst, Cambridge, MA USA. [Zhang, Wandi] Dana Farber Canc Inst, Canc Vaccine Ctr, Boston, MA 02115 USA. [Wu, Catherine J.] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA USA. RI Folco, Eric/M-2665-2013 NR 0 TC 0 Z9 0 U1 3 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 214 EP 215 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100464 ER PT J AU Brown, JR Lawrence, MS Hanna, M Tesar, B Stojanov, P Vartanov, AR Fernandes, SM Sougnez, C MacConaill, L Pochet, N Regev, A Werner, L Gabriel, S Lander, ES Neuberg, D Freedman, AS Getz, G Wu, CJ AF Brown, Jennifer R. Lawrence, Michael S. Hanna, Megan Tesar, Bethany Stojanov, Petar Vartanov, Alexander R. Fernandes, Stacey M. Sougnez, Carrie MacConaill, Laura Pochet, Nathalie Regev, Aviv Werner, Lillian Gabriel, Stacey Lander, Eric S. Neuberg, Donna Freedman, Arnold S. Getz, Gad Wu, Catherine J. TI Novel Germline Genetic Variants Associated with Familial Chronic Lymphocytic Leukemia (CLL) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Brown, Jennifer R.; Freedman, Arnold S.; Wu, Catherine J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA. [Lawrence, Michael S.; Stojanov, Petar; Sougnez, Carrie; Pochet, Nathalie; Regev, Aviv; Gabriel, Stacey; Lander, Eric S.; Getz, Gad] Broad Inst, Cambridge, MA USA. [Hanna, Megan; MacConaill, Laura] Dana Farber Canc Inst, Ctr Canc Genome Discovery, Boston, MA 02115 USA. [Tesar, Bethany; Vartanov, Alexander R.; Fernandes, Stacey M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 215 EP 216 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100466 ER PT J AU Azab, AK Hu, JS Quang, P Azab, F Pitsillides, C Thompson, B Maiso, P Roccaro, AM Sacco, A Ngo, HT Issa, GC Lin, C Kung, AL Vanderkerken, K Ghobrial, IM AF Azab, Abdel Kareem Hu, Jinsong Quang, Phong Azab, Feda Pitsillides, Costas Thompson, Brian Maiso, Patricia Roccaro, Aldo M. Sacco, Antonio Ngo, Hai T. Issa, Ghayas C. Lin, Charles Kung, Andrew L. Vanderkerken, Karin Ghobrial, Irene M. TI Hypoxia Promotes Dissemination of Multiple Myeloma Through Acquisition of Endothelial to Mesenchymal Transition (EMT) Features SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Azab, Abdel Kareem; Quang, Phong; Azab, Feda; Maiso, Patricia; Roccaro, Aldo M.; Sacco, Antonio; Ngo, Hai T.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Hu, Jinsong; Vanderkerken, Karin] Vrije Univ Brussel, Myeloma Ctr Brussels, Brussels, Belgium. [Pitsillides, Costas; Thompson, Brian; Lin, Charles] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Kung, Andrew L.] Childrens Hosp, Boston, MA 02115 USA. RI Vanderkerken, Karin/I-3513-2013 NR 0 TC 1 Z9 1 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 218 EP 218 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100472 ER PT J AU San Miguel, JF Schlag, R Khuageva, NK Dimopoulos, MA Shpilberg, O Kropff, M Spicka, I Petrucci, MT Palumbo, A Samoilova, OS Dmoszynska, A Abdulkadyrov, KM Delforge, M Jiang, B Mateos, MV Anderson, KC Esseltine, DL Liu, K Deraedt, WM Cakana, AZ van de Velde, H Richardson, PG AF San Miguel, Jesus F. Schlag, Rudolf Khuageva, Nuriet K. Dimopoulos, Meletios Athanasios Shpilberg, Ofer Kropff, Martin Spicka, Ivan Petrucci, Maria T. Palumbo, Antonio Samoilova, Olga S. Dmoszynska, Anna Abdulkadyrov, Kudrat M. Delforge, Michel Jiang, Bin Mateos, Maria-Victoria Anderson, Kenneth C. Esseltine, Dixie-Lee Liu, Kevin Deraedt, William M. Cakana, Andrew Z. van de Velde, Helgi Richardson, Paul G. TI Continued Overall Survival Benefit After 5 Years' Follow-up with Bortezomib-Melphalan-Prednisone (VMP) Versus Melphalan-Prednisone (MP) in Patients with Previously Untreated Multiple Myeloma, and No Increased Risk of Second Primary Malignancies: Final Results of the Phase 3 VISTA Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [San Miguel, Jesus F.; Mateos, Maria-Victoria] Hosp Clin Univ, Salamanca, Spain. [Schlag, Rudolf] Praxisklin Dr Schlag, Wurzburg, Germany. [Khuageva, Nuriet K.] SP Botkin Moscow City Clin Hosp, Moscow, Russia. [Dimopoulos, Meletios Athanasios] Univ Athens, Sch Med, Dept Clin Therapeut, GR-11527 Athens, Greece. [Shpilberg, Ofer] Rabin Med Ctr, Inst Hematol, Petah Tiqwa, Israel. [Kropff, Martin] Univ Munster, Munster, Germany. [Spicka, Ivan] Charles Univ Prague, Prague, Czech Republic. [Petrucci, Maria T.] Univ Roma La Sapienza, Rome, Italy. [Palumbo, Antonio] Univ Turin, Div Hematol, Myeloma Unit, AOU S Giovanni Battista, Turin, Italy. [Samoilova, Olga S.] Nizhnii Novgorod Reg Clin Hosp, Novgorod, Russia. [Dmoszynska, Anna] Med Univ Lublin, Lublin, Poland. [Abdulkadyrov, Kudrat M.] St Petersburg Clin Res Inst Hematol & Transfusiol, St Petersburg, Russia. [Delforge, Michel] Belgian Hematol Soc, Myeloma Study Grp, Brussels, Belgium. [Jiang, Bin] Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China. [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Esseltine, Dixie-Lee] Millennium Pharmaceut Inc, Cambridge, MA USA. [Liu, Kevin] Janssen Res & Dev, Raritan, NJ USA. [Deraedt, William M.; van de Velde, Helgi] Janssen Res & Dev, Beerse, Belgium. [Cakana, Andrew Z.] Janssen Res & Dev, High Wycombe, Bucks, England. RI 2011, Secribsal/D-9425-2012 NR 0 TC 4 Z9 4 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 221 EP 222 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100477 ER PT J AU Berdeja, JG Richardson, PG Lonial, S Niesvizky, R Hui, AM Berg, D Gupta, N Liu, GH Di Bacco, A Kumar, S AF Berdeja, Jesus G. Richardson, Paul G. Lonial, Sagar Niesvizky, Ruben Hui, Ai-Min Berg, Deborah Gupta, Neeraj Liu, Guohui Di Bacco, Alessandra Kumar, Shaji TI Phase 1/2 Study of Oral MLN9708, A Novel, Investigational Proteasome Inhibitor, in Combination with Lenalidomide and Dexamethasone in Patients with Previously Untreated Multiple Myeloma (MM) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Berdeja, Jesus G.] Sarah Cannon Res Inst, Nashville, TN USA. [Richardson, Paul G.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. [Niesvizky, Ruben] New York Presbyterian Hosp, Weill Cornell Med Coll, Ctr Excellence Lymphoma & Myeloma, New York, NY USA. [Hui, Ai-Min; Berg, Deborah; Gupta, Neeraj; Liu, Guohui; Di Bacco, Alessandra] Millennium Pharmaceut Inc, Cambridge, MA USA. [Kumar, Shaji] Mayo Clin, Div Hematol, Rochester, MN USA. RI Kumar, Shaji/A-9853-2008 OI Kumar, Shaji/0000-0001-5392-9284 NR 0 TC 4 Z9 4 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 223 EP 223 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100480 ER PT J AU Siegel, DS Dimopoulos, MA Yoon, SS Laubach, JP Kaufman, JL Goldschmidt, H Reece, DE Leleu, X Durrant, S Offner, FC Cavo, M Nagler, A Jagannath, S Graef, T Houp, J Sun, LD Howe, J Wear, SM Anderson, KC AF Siegel, David S. Dimopoulos, Meletios Athanasios Yoon, Sung-Soo Laubach, Jacob P. Kaufman, Jonathan L. Goldschmidt, Hartmut Reece, Donna E. Leleu, Xavier Durrant, Simon Offner, Fritz C. Cavo, Michele Nagler, Arnon Jagannath, Sundar Graef, Thorsten Houp, Jennifer Sun, Linda Howe, Jason Wear, Sandra M. Anderson, Kenneth C. TI Vantage 095: Vorinostat in Combination with Bortezomib in Salvage Multiple Myeloma Patients: Final Study Results of a Global Phase 2b Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Siegel, David S.] Hackensack Univ, Med Ctr, Hackensack, NJ USA. [Dimopoulos, Meletios Athanasios] Univ Athens, Dept Therapeut, Athens, Greece. [Yoon, Sung-Soo] Seoul Natl Univ Hosp, Dept Internal Med, Seoul 110744, South Korea. [Laubach, Jacob P.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Kaufman, Jonathan L.] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA. [Goldschmidt, Hartmut] Univ Klinikum Heidelberg, Med Klin 5, Heidelberg, Germany. [Reece, Donna E.] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada. [Leleu, Xavier] CHRU, Hop Claude Huriez, Serv Malad Sang, Lille, France. [Durrant, Simon] Royal Brisbane & Womens Hosp, Bone Marrow Transplant Unit, Herston, Qld, Australia. [Offner, Fritz C.] UZ Gent, Ghent, Belgium. [Cavo, Michele] Univ Bologna, Sch Med, Seragnoli Inst Hematol, Bologna, Italy. [Nagler, Arnon] Chaim Sheba Med Ctr, Div Hematol, IL-52621 Tel Hashomer, Israel. [Jagannath, Sundar] Mt Sinai Hosp, New York, NY USA. [Graef, Thorsten; Howe, Jason] Merck Res Labs, N Wales, PA USA. [Houp, Jennifer; Sun, Linda] Merck & Co Inc, N Wales, PA USA. [Wear, Sandra M.] Multiple Myeloma Res Consortium, Norwalk, CT USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 223 EP 224 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100481 ER PT J AU Richardson, PG Smith, AR Grupp, SA Kernan, NA Arai, S Haut, PR Triplett, BM Gillio, AP Symons, HJ Adams, RH Horn, BN Lucas, K Martin, PL Mineishi, S Ball, ED Boyer, M Fort, J Kirov, II Lehmann, LE Madigan, C Maglio, ME Massaro, J D'Agostino, RB Hannah, AL Tudone, E Hume, R Iacobelli, M Soiffer, RJ AF Richardson, Paul G. Smith, Angela R. Grupp, Stephan A. Kernan, Nancy A. Arai, Sally Haut, Paul R. Triplett, Brandon M. Gillio, Alfred P., III Symons, Heather J. Adams, Roberta H. Horn, Biljana N. Lucas, Kenneth Martin, Paul L. Mineishi, Shin Ball, Edward D. Boyer, Michael Fort, John Kirov, Ivan I. Lehmann, Leslie E. Madigan, Catherine Maglio, Michelle E. Massaro, Joseph D'Agostino, Ralph B. Hannah, Alison L. Tudone, Elena Hume, Robin Iacobelli, Massimo Soiffer, Robert J. CA Defibrotide Study Grp TI Defibrotide (DF) in the Treatment of Hepatic Veno-Occlusive Disease (VOD) in Stem Cell Transplant (SCT) and Non-SCT Patients (Pts): Early Intervention Improves Outcome - Updated Results of a Treatment IND Expanded Access Protocol SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Smith, Angela R.] Univ Minnesota, Div Pediat Hematol Oncol Bone & Marrow Transplant, Minneapolis, MN USA. [Grupp, Stephan A.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA. [Kernan, Nancy A.] Mem Sloan Kettering Canc Ctr, Pediat BMT Serv, New York, NY 10021 USA. [Arai, Sally] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Haut, Paul R.] Indiana Univ, Simon Canc Ctr, Indianapolis, IN 46204 USA. [Triplett, Brandon M.] St Jude Childrens Hosp, Memphis, TN 38105 USA. [Gillio, Alfred P., III] Hackensack Univ, Med Ctr, Tomorrows Childrens Inst, Hackensack, NJ USA. [Symons, Heather J.] Johns Hopkins Univ, Baltimore, MD USA. [Adams, Roberta H.] Mayo Clin Arizona, Div Hematol & Med Oncol, Scottsdale, AZ USA. [Horn, Biljana N.] UCSF Childrens Hosp, Blood & Marrow Transplant Program, San Francisco, CA USA. [Lucas, Kenneth] Penn State Childrens Hosp, Hershey, PA USA. [Martin, Paul L.] Duke Univ, Med Ctr, Durham, NC USA. [Mineishi, Shin] Univ Michigan, Ann Arbor, MI 48109 USA. [Ball, Edward D.] Moores UCSD Canc Ctr, La Jolla, CA USA. [Boyer, Michael] Primary Childrens Med Ctr, Hem Onc Dept, Salt Lake City, UT 84103 USA. [Fort, John] Miami Childrens Hosp, Miami, FL USA. [Kirov, Ivan I.] Childrens Hosp Orange Cty, Orange, CA 92668 USA. [Lehmann, Leslie E.] Dana Farber Canc Inst, Pediat Oncol HSCT, Boston, MA 02115 USA. [Madigan, Catherine] Rady Childrens Hosp UCSD, San Diego, CA USA. [Maglio, Michelle E.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Massaro, Joseph] Boston Univ, Dept Stat, Boston, MA 02215 USA. [Hannah, Alison L.] Gentium SpA, Como, Italy. [Tudone, Elena; Hume, Robin; Defibrotide Study Grp] Gentium, Como, Italy. [Iacobelli, Massimo] Gentium SpA, Med Sci Dept, Villa Guardia, Italy. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 226 EP 227 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100488 ER PT J AU Warlick, ED McClune, B Pedersen, TL Awn, KW Antin, JH Cahn, JY DeLima, M Gupta, V Marks, DI Bunjes, D DiPersio, JF Devine, S Weisdorf, DJ AF Warlick, Erica D. McClune, Brian Pedersen, Tanya L. Awn, Kwang W. Antin, Joseph H. Cahn, Jean-Yves DeLima, Marcos Gupta, Vikas Marks, David I. Bunjes, Donald DiPersio, John F. Devine, Steven Weisdorf, Daniel J. TI Older Adults with Chronic Myelogenous Leukemia (CML), During the Tyrosine Kinase Inhibitor (TKI) Era, Can Be Successfully Treated with Reduced Intensity Conditioning (RIC) Hematopoietic Cell Transplant (HCT) Using Sibling or Unrelated Donors: A Center for International Blood and Marrow Transplant Research (CIBMTR) Analysis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Warlick, Erica D.; McClune, Brian] Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA. [Pedersen, Tanya L.] Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA. [Awn, Kwang W.] Med Coll Wisonsin, Div Biostat, Milwaukee, WI USA. [Antin, Joseph H.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Cahn, Jean-Yves] CHU Grenoble, F-38043 Grenoble 09, France. [DeLima, Marcos] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA. [Gupta, Vikas] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada. [Marks, David I.] Bristol Royal Hosp Children, Dept Adult Bone Marrow Transplantat, Bristol, Avon, England. [Bunjes, Donald] Univ Ulm, Ulm, Germany. [DiPersio, John F.] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA. [Devine, Steven] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA. RI Cahn, Jean-Yves/M-6493-2014 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 230 EP 231 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100495 ER PT J AU Kerenyi, MA Hsu, J Shao, Z Orkin, SH AF Kerenyi, Marc A. Hsu, Jessica Shao, Zhen Orkin, Stuart H. TI Histone Demethylase LSD1 Is Required to Repress Hematopoietic Stem Cell Signatures in Mature Blood Cells to Permit Terminal Differentiation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kerenyi, Marc A.; Hsu, Jessica; Shao, Zhen] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA. [Orkin, Stuart H.] Childrens Hosp, Dept Pediat Oncol, Boston, MA 02115 USA. [Orkin, Stuart H.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Harvard Stem Cell Inst,Howard Hughes Med Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 254 EP 254 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100551 ER PT J AU Chambwe, N Kormaksson, M De, S Michor, F Johnson, N Scott, DW Gascoyne, RD Melnick, A Campagne, F Shaknovich, R AF Chambwe, Nyasha Kormaksson, Matthias De, Subhajyoti Michor, Franziska Johnson, Nathalie Scott, David W. Gascoyne, Randy D. Melnick, Ari Campagne, Fabien Shaknovich, Rita TI Epigenetic Profiling of Primary DLBCLs Reveals Novel DNA Methylation-Based Clusters and New Underlying Mechanisms of Lymphomagenesis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Chambwe, Nyasha; Campagne, Fabien] Cornell Univ, Dept Physiol & Biophys, Inst Computat Biomed, Weill Med Coll, New York, NY 10021 USA. [Kormaksson, Matthias] Weill Cornell Med Ctr, New York, NY USA. [De, Subhajyoti; Michor, Franziska] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Johnson, Nathalie] McGill Univ, Jewish Gen Hosp, Dept Med, Montreal, PQ H3T 1E2, Canada. [Scott, David W.; Gascoyne, Randy D.] British Columbia Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC V5Z 4E6, Canada. [Melnick, Ari; Shaknovich, Rita] Weill Cornell Med Coll, New York, NY USA. RI Chambwe, Nyasha/M-7796-2013 OI Chambwe, Nyasha/0000-0002-2812-0122 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 256 EP 256 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100557 ER PT J AU Roti, G Carlton, A Ross, KN Markstein, M Pajcini, K Perrimon, N Kung, AL Pear, WS Blacklow, SC Aster, JC Stegmaier, K AF Roti, Giovanni Carlton, Annie Ross, Kenneth N. Markstein, Michele Pajcini, Kostandin Perrimon, Norbert Kung, Andrew L. Pear, Warren S. Blacklow, Stephen C. Aster, Jon C. Stegmaier, Kimberly TI Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Roti, Giovanni; Carlton, Annie; Kung, Andrew L.; Stegmaier, Kimberly] Childrens Hosp, Boston, MA 02115 USA. [Ross, Kenneth N.] Harvard Univ, Broad Inst, Cambridge, MA 02138 USA. [Ross, Kenneth N.] MIT, Cambridge, MA 02139 USA. [Markstein, Michele; Perrimon, Norbert] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA. [Pajcini, Kostandin; Pear, Warren S.] Abramson Family Canc Res Inst, Philadelphia, PA USA. [Aster, Jon C.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 8 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 256 EP 256 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100556 ER PT J AU Weigert, O Bird, L Kopp, N Lane, AA Chapuy, B van Bodegom, D Marubayashi, S Yoda, A Romanet, V Murakami, M Sallan, SE Levine, RL Kung, AL Radimerski, T Weinstock, DM AF Weigert, Oliver Bird, Liat Kopp, Nadja Lane, Andrew A. Chapuy, Bjoern van Bodegom, Diederik Marubayashi, Sachie Yoda, Akinori Romanet, Vincent Murakami, Masato Sallan, Stephen E. Levine, Ross L. Kung, Andrew L. Radimerski, Thomas Weinstock, David M. TI HSP90 Inhibition Targets JAK2 and Is Highly Effective in CRLF2-Rearranged Acute Lymphoblastic Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kung, Andrew L.] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Marubayashi, Sachie; Levine, Ross L.] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA. [Romanet, Vincent; Murakami, Masato; Radimerski, Thomas] Novartis Inst Biomed Res, Basel, Switzerland. [Sallan, Stephen E.] Dana Farber Canc Inst Hosp Boston, Boston, MA USA. [Levine, Ross L.] Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY 10021 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Kung, Andrew L.] Childrens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 265 EP 266 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100577 ER PT J AU Yang, G Zhou, YS Liu, X Cao, Y Hunter, Z Treon, SP AF Yang, Guang Zhou, Yangsheng Liu, Xia Cao, Yang Hunter, Zachary Treon, Steven P. TI Disruption of MYD88 Pathway Signaling Leads to Loss of Constitutive IRAK1, NF-kappa beta and JAK/STAT Signaling and Induces Apoptosis of Cells Expressing the MYD88 L265P Mutation in Waldenstrom's Macroglobalinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Yang, Guang; Zhou, Yangsheng; Liu, Xia; Cao, Yang; Hunter, Zachary] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Treon, Steven P.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 1 Z9 1 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 274 EP 275 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100598 ER PT J AU Roccaro, AM Sacco, A Azab, AK Tai, YT Maiso, P Zhang, Y Liu, Y Reagan, M Azab, F Issa, GC Ngo, HT Quang, P Anderson, KC Dalla-Favera, R Ghobrial, IM AF Roccaro, Aldo M. Sacco, Antonio Azab, Abdel Kareem Tai, Yu-Tzu Maiso, Patricia Zhang, Yong Liu, Yang Reagan, Michaela Azab, Feda Issa, Ghayas C. Ngo, Hai T. Quang, Phong Anderson, Kenneth C. Dalla-Favera, Riccardo Ghobrial, Irene M. TI Stroma-Derived Exosomes Mediate Oncogenesis in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Dalla-Favera, Riccardo] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Inst Canc Genet, New York, NY USA. RI Reagan, Michaela/E-3549-2017 NR 0 TC 0 Z9 0 U1 0 U2 6 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 286 EP 286 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100626 ER PT J AU Pal, J Nanjappa, P Vahia, AV Shi, JL Shammas, MA Munshi, NC AF Pal, Jagannath Nanjappa, Puru Vahia, Ankit V. Shi, Jialan Shammas, Masood A. Munshi, Nikhil C. TI A Novel Role of Telomerase in DNA Repair and Genome Maintenance in Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Pal, Jagannath; Munshi, Nikhil C.] VA Boston Healthcare Syst, Boston, MA USA. [Nanjappa, Puru; Vahia, Ankit V.; Shammas, Masood A.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Shi, Jialan] VA Hlth Care Syst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 287 EP 287 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100629 ER PT J AU Richardson, PG Siegel, DS Vij, R Hofmeister, CC Jagannath, S Chen, C Lonial, S Jakubowiak, AJ Bahlis, NJ Baz, R Larkins, G Chen, M Zaki, M Anderson, KC AF Richardson, Paul G. Siegel, David S. Vij, Ravi Hofmeister, Craig C. Jagannath, Sundar Chen, Christine Lonial, Sagar Jakubowiak, Andrzej J. Bahlis, Nizar J. Baz, Rachid Larkins, Gail Chen, Min Zaki, Mohamed Anderson, Kenneth C. TI Randomized, Open Label Phase 1/2 Study of Pomalidomide (POM) Alone or in Combination with Low-Dose Dexamethasone (LoDex) in Patients (Pts) with Relapsed and Refractory Multiple Myeloma Who Have Received Prior Treatment That Includes Lenalidomide (LEN) and Bortezomib (BORT): Phase 2 Results SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Richardson, Paul G.; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Siegel, David S.] Hackensack Univ, Med Ctr, John Theurer Canc Ctr, Hackensack, NJ USA. [Vij, Ravi] Washington Univ, Sch Med, Div Oncol, St Louis, MO USA. [Hofmeister, Craig C.] Ohio State Univ, Med Ctr, Div Hematol, Columbus, OH 43210 USA. [Jagannath, Sundar] St Vincents Comprehens Canc Ctr, New York, NY USA. [Chen, Christine] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada. [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. [Jakubowiak, Andrzej J.] Univ Michigan, Ann Arbor, MI 48109 USA. [Bahlis, Nizar J.] Univ Calgary, Div Hematol, Calgary, AB, Canada. [Baz, Rachid] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL 33612 USA. [Larkins, Gail; Chen, Min; Zaki, Mohamed] Celgene Corp, Summit, NJ USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 290 EP 291 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100635 ER PT J AU Hill, JA Koo, S Suarez, BG Ho, VT Cutler, C Koreth, J Armand, P Alyea, EP Baden, LR Antin, JH Soiffer, RJ Marty, FM AF Hill, Joshua A. Koo, Sophia Suarez, Belisa Guzman Ho, Vincent T. Cutler, Corey Koreth, John Armand, Philippe Alyea, Edwin P., III Baden, Lindsey R. Antin, Joseph H. Soiffer, Robert J. Marty, Francisco M. TI HHV-6-Associated Post-Transplantation Acute Limbic Encephalitis Following Cord Blood Stem Cell Transplantation: A Cohort Analysis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Hill, Joshua A.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Koo, Sophia; Suarez, Belisa Guzman; Baden, Lindsey R.; Marty, Francisco M.] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Ho, Vincent T.; Cutler, Corey; Koreth, John; Armand, Philippe; Alyea, Edwin P., III; Antin, Joseph H.; Soiffer, Robert J.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 296 EP 297 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100650 ER PT J AU Cutler, CS Shoemaker, D Ballen, KK Robbins, D Desponts, C Kao, GS Chen, YBA Dey, BR McAfee, SL Alyea, EP Koreth, J Armand, P Ho, VT Kim, HT Goessling, W North, TE Spitzer, TR Soiffer, RJ Antin, JH Ritz, J Mendlein, J Multani, PS AF Cutler, Corey S. Shoemaker, Daniel Ballen, Karen K. Robbins, David Desponts, Caroline Kao, Grace S. Chen, Yi-Bin A. Dey, Bimalangshu R. McAfee, Steven L. Alyea, Edwin P., III Koreth, John Armand, Philippe Ho, Vincent T. Kim, Haesook T. Goessling, Wolfram North, Trista E. Spitzer, Thomas R. Soiffer, Robert J. Antin, Joseph H. Ritz, Jerome Mendlein, John Multani, Pratik S. TI FT1050 (16,16-dimethyl Prostaglandin E2)-Enhanced Umbilical Cord Blood Accelerates Hematopoietic Engraftment After Reduced Intensity Conditioning and Double Umbilical Cord Blood Transplantation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Cutler, Corey S.; Kao, Grace S.; Alyea, Edwin P., III; Koreth, John; Armand, Philippe; Ho, Vincent T.; Soiffer, Robert J.; Antin, Joseph H.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Shoemaker, Daniel; Robbins, David; Desponts, Caroline; Mendlein, John; Multani, Pratik S.] Fate Therapeut Inc, San Diego, CA USA. [Ballen, Karen K.; Chen, Yi-Bin A.; Dey, Bimalangshu R.; McAfee, Steven L.; Spitzer, Thomas R.] Massachusetts Gen Hosp, Bone Marrow Transplant Unit, Boston, MA 02114 USA. [Kim, Haesook T.] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Goessling, Wolfram] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Goessling, Wolfram] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA. [Goessling, Wolfram] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA. [North, Trista E.] Harvard Univ, Sch Med, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA. NR 0 TC 5 Z9 5 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 298 EP 299 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100654 ER PT J AU Mueller, L Milsom, MD Harris, C Vyas, R Brumme, K Parmar, K Schambach, A Grassman, E Park, IH Wendy, L Strait, K Schlaeger, T Devine, AL D'Andrea, AD Daley, GQ Williams, DA AF Mueller, Lars Milsom, Michael D. Harris, Chad Vyas, Rutesh Brumme, Kristina Parmar, Kalindi Schambach, Axel Grassman, Elke Park, In-Hyun Wendy, London Strait, Kelly Schlaeger, Thorsten Devine, Alexander L. D'Andrea, Alan D. Daley, George Q. Williams, David A. TI Gene-Correction Rescues Reprogramming of Fanconi Anemia Fibroblasts and Enables Hematopoietic Differentiation of FA Induced Pluripotent Stem Cells in Vitro and In Vivo SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Mueller, Lars; Harris, Chad; Park, In-Hyun; Wendy, London] Childrens Hosp Boston, Div Hematol Oncol, Boston, MA USA. [Brumme, Kristina] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA. [D'Andrea, Alan D.] Dana Farber Canc Inst, Dept Rad Onc, Boston, MA 02115 USA. [Schambach, Axel] Hannover Med Sch, Dept Expt Hematol, D-3000 Hannover, Germany. [Grassman, Elke] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA. [Daley, George Q.] Childrens Hosp, Childrens Hosp Boston, Boston, MA 02115 USA. [Daley, George Q.] Howard Hughes Med Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 309 EP 309 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100673 ER PT J AU Steinbicker, AU Mayeur, C Lohmeyer, LK Leyton, P Kao, SM Pappas, AE Nobre, R Peterson, RT Bloch, DB Yu, PB Bloch, KD AF Steinbicker, Andrea U. Mayeur, Claire Lohmeyer, Lisa K. Leyton, Patricio Kao, Sonya M. Pappas, Alexandra E. Nobre, Rita Peterson, Randall T. Bloch, Donald B. Yu, Paul B. Bloch, Kenneth D. TI Alk3, a BMP Type I Receptor Is Required for the Induction of Hepatic Hepcidin Gene Expression by Interleukin-6 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lohmeyer, Lisa K.] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Anesthesia Ctr Crit Care Res, Boston, MA 02114 USA. [Peterson, Randall T.; Yu, Paul B.] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 314 EP 314 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597100687 ER PT J AU Hoggatt, J Mohammad, KS Chitteti, BR Singh, P Speth, JM Hu, PR Poteat, B Srour, E Guise, T Pelus, LM AF Hoggatt, Jonathan Mohammad, Khalid S. Chitteti, Brahmananda Reddy Singh, Pratibha Speth, Jennifer M. Hu, Peirong Poteat, Bradley Srour, Edward Guise, Theresa Pelus, Louis M. TI Bone Marrow Niche Attenuation by Non-Steroidal Anti-Inflammatory Drugs Mobilizes Hematopoietic Stem and Progenitor Cells by Differing Mechanisms SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Hoggatt, Jonathan] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Harvard Stem Cell Inst, Boston, MA USA. [Mohammad, Khalid S.; Chitteti, Brahmananda Reddy; Singh, Pratibha; Speth, Jennifer M.; Hu, Peirong; Poteat, Bradley; Srour, Edward; Guise, Theresa; Pelus, Louis M.] Indiana Univ Sch Med, Indianapolis, IN USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 328 EP 329 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597100725 ER PT J AU Miller, P Al-Shahrour, F Hartwell, KA Chu, LP Marcus, J Puram, RV Puissant, A Callahan, K Ashton, JM McConkey, ME Poveromo, L Cowley, G Kharas, MG Labelle, M Shterental, S Al-Hajj, M Shelton, C Armstrong, SA Root, DE Hynes, R Mukherjee, S Stegmaier, K Jordan, CT Ebert, BL AF Miller, Peter Al-Shahrour, Fatima Hartwell, Kimberly A. Chu, Lisa P. Marcus, Jaras Puram, Rishi V. Puissant, Alexandre Callahan, Kevin Ashton, John M. McConkey, Marie Ellen Poveromo, Luke Cowley, Glenn Kharas, Michael G. Labelle, Myriam Shterental, Sebastian Al-Hajj, Muhammad Shelton, Christopher Armstrong, Scott A. Root, David E. Hynes, Richard Mukherjee, Siddhartha Stegmaier, Kimberly Jordan, Craig T. Ebert, Benjamin L. TI In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Miller, Peter] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Callahan, Kevin; Jordan, Craig T.] Univ Rochester, Med Ctr, Wilmot Canc Ctr, Rochester, NY 14642 USA. [Ashton, John M.] Univ Rochester, Sch Med & Dent, Dept Biomed Genet, Rochester, NY USA. [Cowley, Glenn; Root, David E.] Broad Inst, Cambridge, MA USA. [Kharas, Michael G.] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10021 USA. [Labelle, Myriam; Hynes, Richard] MIT, Ctr Canc, Cambridge, MA 02139 USA. [Puissant, Alexandre; Armstrong, Scott A.; Stegmaier, Kimberly] Dana Farber Canc Inst, Boston, MA 02115 USA. [Armstrong, Scott A.; Stegmaier, Kimberly] Childrens Hosp, Boston, MA 02115 USA. [Mukherjee, Siddhartha] Columbia Univ, Sch Med, Dept Med, Irving Canc Res Ctr, New York, NY 10027 USA. [Ebert, Benjamin L.] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA. [Marcus, Jaras; McConkey, Marie Ellen] Brigham & Womens, Hematol, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 344 EP 345 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101029 ER PT J AU Hartwell, KA Miller, PG Stewart, AL Kahn, AR Logan, DJ Negri, J Duvet, M Chattopadhyay, S Shterental, S Chu, LP Shieh, JH Jaeraas, M Dancik, V Narayan, R Huang, C Haydu, JE Mukherjee, S Shamji, AF Tolliday, NJ Carpenter, AE Schreiber, SL Stern, AM Moore, MAS Scadden, DT Ebert, BL Golub, TR AF Hartwell, Kimberly A. Miller, Peter G. Stewart, Alison L. Kahn, Alissa R. Logan, David J. Negri, Joseph Duvet, Mildred Chattopadhyay, Shrikanta Shterental, Sebastian Chu, Lisa P. Shieh, Jae Hung Jaeraas, Marcus Dancik, Vladimir Narayan, Rajiv Huang, Christina Haydu, J. Erika Mukherjee, Siddhartha Shamji, Alykhan F. Tolliday, Nicola J. Carpenter, Anne E. Schreiber, Stuart L. Stern, Andrew M. Moore, Malcolm A. S. Scadden, David T. Ebert, Benjamin L. Golub, Todd R. TI Niche-Based Screening Reveals Leukemia Stem Cell Specific Therapeutics SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Hartwell, Kimberly A.; Miller, Peter G.] Harvard Univ, Sch Med, Boston, MA USA. [Golub, Todd R.] Harvard Univ, Broad Inst, Canc Program, Cambridge, MA 02138 USA. [Stewart, Alison L.; Dancik, Vladimir; Narayan, Rajiv; Huang, Christina; Shamji, Alykhan F.; Tolliday, Nicola J.] Massachusetts Inst, Cambridge, MA USA. [Kahn, Alissa R.; Shieh, Jae Hung; Moore, Malcolm A. S.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Chattopadhyay, Shrikanta] Broad Inst MIT & Harvard, Ctr Regenerat Med, Boston, MA USA. [Duvet, Mildred] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA. [Chattopadhyay, Shrikanta] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Chattopadhyay, Shrikanta] Harvard Stem Cell Inst, Boston, MA USA. [Ebert, Benjamin L.] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA. [Chu, Lisa P.] Brigham & Womens, Hematol, Boston, MA USA. [Mukherjee, Siddhartha] Columbia Univ, Sch Med, Dept Med, Irving Canc Res Ctr, New York, NY 10027 USA. [Schreiber, Stuart L.] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA. [Schreiber, Stuart L.] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA. [Scadden, David T.] Harvard Univ, Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02115 USA. [Scadden, David T.] Harvard Univ, Ctr Canc, Dept Stem Cell & Regenerat Biol, Boston, MA 02115 USA. [Scadden, David T.] Harvard Stem Cell Inst, Boston, MA USA. [Golub, Todd R.] MIT, Cambridge, MA 02139 USA. RI Carpenter, Anne/C-4982-2008 OI Carpenter, Anne/0000-0003-1555-8261 NR 0 TC 0 Z9 0 U1 2 U2 5 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 345 EP 346 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101031 ER PT J AU Yusuf, RZ Acharya, SS Yu, V Saez, B Duvet, M Scadden, E Warraich, G Clish, C Churchill, M Doench, J Logan, DJ Cook, C Das, S Brown, A Sykes, SM Chattopadhyay, S Carpenter, AE Vander Heiden, M Armstrong, SA Mukherjee, S Ebert, BL Scadden, DT AF Yusuf, Rushdia Z. Acharya, Sanket S. Yu, Vionnie Saez, Borja Duvet, Mildred Scadden, Elizabeth Warraich, Gohar Clish, Clary Churchill, Michael Doench, John Logan, David J. Cook, Colleen Das, Sudeshna Brown, Adam Sykes, Stephen M. Chattopadhyay, Shrikanta Carpenter, Anne E. Vander Heiden, Mathew Armstrong, Scott A. Mukherjee, Siddhartha Ebert, Benjamin L. Scadden, David T. TI Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Yusuf, Rushdia Z.; Scadden, David T.] Harvard Univ, Ctr Canc, Dept Stem Cell & Regenerat Biol, Boston, MA 02115 USA. [Acharya, Sanket S.] Harvard Univ, Grad Program Immunol, Boston, MA 02115 USA. [Chattopadhyay, Shrikanta] Broad Inst Harvard & MIT, Ctr Regenerat Med, Boston, MA USA. [Churchill, Michael; Mukherjee, Siddhartha] Columbia Univ, Sch Med, Dept Med, New York, NY 10027 USA. [Churchill, Michael; Mukherjee, Siddhartha] Columbia Univ, Sch Med, Irving Canc Res Ctr, New York, NY 10027 USA. [Chattopadhyay, Shrikanta] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Vander Heiden, Mathew] MIT, Koch Inst Canc Res, Boston, MA USA. [Vander Heiden, Mathew; Armstrong, Scott A.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Armstrong, Scott A.] Childrens Hosp, Boston, MA 02115 USA. [Ebert, Benjamin L.] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA. [Acharya, Sanket S.; Saez, Borja; Cook, Colleen; Sykes, Stephen M.] Harvard Univ, Massachusetts Gen Hosp, Ctr Regenerat Med, Dept Stem Cell & Regenerat Biol,Harvard Stem Cell, Boston, MA 02115 USA. RI Carpenter, Anne/C-4982-2008 OI Carpenter, Anne/0000-0003-1555-8261 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 345 EP 345 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101030 ER PT J AU Adamia, S Bar-Natan, M Haibe-Kains, B Avet-Loiseau, H Lode, L Pevzner, S Verselis, S Fox, E Galinsky, I Quackenbush, J Stone, RM Griffin, JD AF Adamia, Sophia Bar-Natan, Michal Haibe-Kains, Benjamin Avet-Loiseau, Herve Lode, Laurence Pevzner, Samuel Verselis, Sigitas Fox, Edward Galinsky, Ilene Quackenbush, John Stone, Richard M. Griffin, James D. TI Genome-Wide Aberrant Splicing in Patients with Acute Myeloid Leukemia (AML) Indetifies Potential Novel Targets SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Pevzner, Samuel] Dana Farber Canc Inst, Canc Biol CCSB, Boston, MA 02115 USA. [Adamia, Sophia] Harvard Univ, Sch Med, Boston, MA USA. [Lode, Laurence] CHU Nantes, Inst Biol, F-44035 Nantes 01, France. [Verselis, Sigitas] Dana Farber Canc Inst, Mol Diagnost Lab, Boston, MA 02115 USA. RI Haibe-Kains, Benjamin/D-3702-2011 OI Haibe-Kains, Benjamin/0000-0002-7684-0079 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 346 EP 346 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101032 ER PT J AU Wang, LL Shalek, AK Gaublomme, J Yosef, N Brown, JR Neuberg, D Hacohen, N Park, H Wu, CJ AF Wang, Lili Shalek, Alex K. Gaublomme, Jellert Yosef, Nir Brown, Jennifer R. Neuberg, Donna Hacohen, Nir Park, Hongkun Wu, Catherine J. TI Sensitivity to Wnt Pathway Inhibition in CLL Is Associated with Specific Gene Expression Signatures SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Wang, Lili] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Shalek, Alex K.; Gaublomme, Jellert; Park, Hongkun] Harvard Univ, Cambridge, MA 02138 USA. [Brown, Jennifer R.; Wu, Catherine J.] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA USA. [Neuberg, Donna] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 364 EP 364 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101072 ER PT J AU Shah, PK Minvielle, S Avet-Loiseau, H Li, C Munshi, NC AF Shah, Parantu K. Minvielle, Stephane Avet-Loiseau, Herve Li, Cheng Munshi, Nikhil C. TI Are Gene Expression Signatures Treatment Specific? SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Shah, Parantu K.; Li, Cheng] Dana Farber Canc Inst, Boston, MA 02115 USA. [Minvielle, Stephane; Avet-Loiseau, Herve] CHU Nantes, F-44035 Nantes 01, France. [Munshi, Nikhil C.] VA Boston Healthcare Syst, Boston, MA USA. RI Minvielle, Stephane/K-8251-2015 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 367 EP 367 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101078 ER PT J AU Dimopoulos, MA Jagannath, S Yoon, SS Siegel, DS Lonial, S Hajek, R Facon, T Rosinol, L Blacklock, HA Goldschmidt, H Hungria, V Spencer, A Palumbo, A Reece, DE Graef, T Houp, J Sun, LD Eid, JE Anderson, KC AF Dimopoulos, Meletios Athanasios Jagannath, Sundar Yoon, Sung-Soo Siegel, David S. Lonial, Sagar Hajek, Roman Facon, Thierry Rosinol, Laura Blacklock, Hilary Anne Goldschmidt, Hartmut Hungria, Vania Spencer, Andrew Palumbo, Antonio Reece, Donna E. Graef, Thorsten Houp, Jennifer Sun, Linda Eid, Joseph E. Anderson, Kenneth C. TI Vantage 088: Vorinostat in Combination with Bortezomib in Patients with Relapsed/Refractory Multiple Myeloma: Results of a Global, Randomized Phase 3 Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Dimopoulos, Meletios Athanasios] Univ Athens, Dept Therapeut, Athens, Greece. [Yoon, Sung-Soo] Seoul Natl Univ Hosp, Seoul 110744, South Korea. [Jagannath, Sundar] Mt Sinai Hosp, New York, NY 10029 USA. [Siegel, David S.] Hackensack Univ, John Theurer Canc Ctr, Med Ctr, Hackensack, NJ USA. [Lonial, Sagar] Emory Univ, Dept Hematol & Med Oncol, Sch Med, Atlanta, GA 30322 USA. [Hajek, Roman] Masaryk Univ, Brno 62500, Czech Republic. [Hajek, Roman] Univ Hosp Brno, Dept Internal Med & Hematooncol, Brno 62500, Czech Republic. [Facon, Thierry] Hop Claude Huriez, Serv Malad Sang, Lille, France. [Rosinol, Laura] Hosp Clin Barcelona, Barcelona, Spain. [Blacklock, Hilary Anne] Middlemore Hosp, Auckland 6, New Zealand. [Goldschmidt, Hartmut] Univ Klinikum Heidelberg, Med Klin 5, Heidelberg, Germany. [Hungria, Vania] Santa Casa Sao Paulo, Sao Paulo, Brazil. [Spencer, Andrew] Monash Univ, Alfred Hosp, Melbourne, Vic 3181, Australia. [Palumbo, Antonio] Univ Turin, Myeloma Unit, Div Hematol, AOU S Giovanni Battista, Turin, Italy. [Reece, Donna E.] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada. [Graef, Thorsten; Eid, Joseph E.] Merck Res Labs, Upper Gwynedd, PA USA. [Houp, Jennifer; Sun, Linda] Merck & Co Inc, N Wales, PA USA. [Anderson, Kenneth C.] Dana Farber Canc Inst, Boston, MA 02115 USA. RI Hungria, Vania/G-3141-2012; FACON, THIERRY/M-9736-2014 OI FACON, THIERRY/0000-0001-7705-8460 NR 0 TC 6 Z9 6 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 368 EP 369 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101082 ER PT J AU Richardson, PG Alsina, M Weber, DM Coutre, SE Lonial, S Gasparetto, C Warsi, G Ondovik, M Mukhopadhyay, S Snodgrass, S Schlossman, R AF Richardson, Paul G. Alsina, Melissa Weber, Donna M. Coutre, Steven E. Lonial, Sagar Gasparetto, Cristina Warsi, Ghulam Ondovik, Michael Mukhopadhyay, Sutapa Snodgrass, Susan Schlossman, Robert TI Phase II Study of the Pan-Deacetylase Inhibitor Panobinostat in Combination with Bortezomib and Dexamethasone in Relapsed and Bortezomib-Refractory Multiple Myeloma (PANORAMA 2) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Richardson, Paul G.; Schlossman, Robert] Dana Farber Canc Inst, Boston, MA 02115 USA. [Alsina, Melissa] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. [Weber, Donna M.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Coutre, Steven E.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Lonial, Sagar] Emory Univ, Winship Canc Inst, Sch Med, Atlanta, GA USA. [Gasparetto, Cristina] Duke Univ, Div Cellular Therapy, Med Ctr, Durham, NC USA. [Warsi, Ghulam; Ondovik, Michael; Mukhopadhyay, Sutapa; Snodgrass, Susan] Novartis Pharmaceut, E Hanover, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 370 EP 371 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101085 ER PT J AU Richardson, PG Wolf, JL Jakubowiak, AJ Zonder, JA Lonial, S Irwin, D Densmore, J Krishnan, A Raje, NS Bar, MH Schlossman, R Ghobrial, IM Munshi, NC Martin, T Laubach, JP Allerton, JP Hideshima, T Sportelli, P Gardner, L Anderson, KC AF Richardson, Paul G. Wolf, Jeffrey Lee Jakubowiak, Andrzej J. Zonder, Jeffrey A. Lonial, Sagar Irwin, David Densmore, John Krishnan, Amrita Raje, Noopur S. Bar, Michael H. Schlossman, Robert Ghobrial, Irene M. Munshi, Nikhil C. Martin, Thomas Laubach, Jacob P. Allerton, Jeffrey P. Hideshima, Teru Sportelli, Peter Gardner, Lesa Anderson, Kenneth C. TI Perifosine Plus Bortezomib and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Bortezomib: Final Results of a Phase I/II Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Richardson, Paul G.; Schlossman, Robert; Ghobrial, Irene M.; Munshi, Nikhil C.; Laubach, Jacob P.; Hideshima, Teru; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Wolf, Jeffrey Lee; Martin, Thomas] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Jakubowiak, Andrzej J.] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA. [Zonder, Jeffrey A.] Karmanos Canc Inst, Myeloma Program, Detroit, MI USA. [Lonial, Sagar] Emory Univ, Winship Canc Inst, Sch Med, Atlanta, GA USA. [Irwin, David] Alta Bates Canc Ctr, Berkeley, CA USA. [Densmore, John] Univ Virginia, Hlth Sci Ctr, Charlottesville, VA USA. [Krishnan, Amrita] City Hope Natl Med Ctr, Duarte, CA 91010 USA. [Raje, Noopur S.] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Boston, MA 02114 USA. [Bar, Michael H.] Bennett Canc Ctr, Stamford, CT USA. [Allerton, Jeffrey P.] Penn State Hershey Med Grp, State Coll, PA USA. [Sportelli, Peter; Gardner, Lesa] Keryx Biopharmaceut Inc, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 371 EP 371 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101086 ER PT J AU Freytes, CO Vesole, DH Zhong, XB Le-Rademacher, J Dispenzieri, A Lonial, S Milone, G Hari, P AF Freytes, Cesar O. Vesole, David H. Zhong, Xiaobo Le-Rademacher, Jennifer Dispenzieri, Angela Lonial, Sagar Milone, Gustavo Hari, Parameswaran TI Second Transplants in Relapsed Multiple Myeloma (MM): Autologous (AHCT) Versus Non-Myeloablative/Reduced Intensity (NST/RIC) Allogeneic Transplantation (AlloHCT) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Freytes, Cesar O.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Freytes, Cesar O.] S Vet Hlth Care Syst, BMT, San Antonio, TX USA. [Vesole, David H.] Hackensack Univ, John Theurer Canc Ctr, Med Ctr, Hackensack, NJ USA. [Zhong, Xiaobo] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. [Le-Rademacher, Jennifer; Hari, Parameswaran] Med Coll Wisconsin CIBMTR, Rochester, MN USA. [Dispenzieri, Angela] Mayo Clin, Rochester, MN USA. [Lonial, Sagar] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA. [Milone, Gustavo] FUNDALEU, Buenos Aires, DF, Argentina. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 375 EP 375 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101095 ER PT J AU Field, J Lin, G Okam, M Majerus, E Onyekwere, O Ross, A Neuberg, D Campigotto, F Nathan, DG Linden, J AF Field, Joshua Lin, Gene Okam, Maureen Majerus, Elaine Onyekwere, Onyinye Ross, Ainsley Neuberg, Donna Campigotto, Federico Nathan, David G. Linden, Joel TI Regadenoson, An Adenosine 2A Receptor Agonist, Is Safe and Inhibits Invariant NKT Cells in Sickle Cell Disease SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Field, Joshua] BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI USA. [Lin, Gene; Linden, Joel] La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA USA. [Okam, Maureen; Ross, Ainsley] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Majerus, Elaine] Washington Univ, Sch Med, Div Hematol, St Louis, MO USA. [Onyekwere, Onyinye] Howard Univ, Ctr Sickle Cell Dis, Washington, DC 20059 USA. [Campigotto, Federico] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 388 EP 388 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101120 ER PT J AU Silverman, LB Stevenson, K Vrooman, LM Supko, JG Asselin, B Athale, U Clavell, LA Cole, P Kelly, KM Laverdiere, C Michon, B Schorin, MA Schwartz, C Neuberg, D Sallan, SE AF Silverman, Lewis B. Stevenson, Kristen Vrooman, Lynda M. Supko, Jeffrey G. Asselin, Barbara Athale, Uma Clavell, Luis A. Cole, Peter Kelly, Kara M. Laverdiere, Caroline Michon, Bruno Schorin, Marshall A. Schwartz, Cindy Neuberg, Donna Sallan, Stephen E. TI Randomized Comparison of IV PEG and IM E. Coli Asparaginase in Children and Adolescents with Acute Lymphoblastic Leukemia: Results of the DFCI ALL Consortium Protocol 05-01 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Silverman, Lewis B.; Sallan, Stephen E.] Childrens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. [Stevenson, Kristen] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Supko, Jeffrey G.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Asselin, Barbara] Univ Rochester, Sch Med, Dept Pediat, Golisano Childrens Hosp URMC, Rochester, NY 14642 USA. [Athale, Uma] McMaster Univ, Div Pediat Hematol Oncol, Hamilton, ON, Canada. [Clavell, Luis A.] San Jorge Childrens Hosp, San Juan, PR USA. [Cole, Peter] Montefiore Med Ctr, Bronx, NY 10467 USA. [Kelly, Kara M.] Columbia Univ, Div Pediat Oncol, Med Ctr, New York, NY USA. [Laverdiere, Caroline] Hosp St Justine, Montreal, PQ, Canada. [Michon, Bruno] Ctr Hosp Univ Quebec, Ste Foy, PQ, Canada. [Schorin, Marshall A.] Inova Fairfax Hosp Children, Providence, RI USA. [Schwartz, Cindy] Brown Univ, Hasbro Childrens Hosp, Providence, RI 02912 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 398 EP 399 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101145 ER PT J AU Tai, YT Chang, BY Kong, SY Fulciniti, M Yang, G Calle, Y Hu, YG Lin, JH Zhao, JJ Cea, M Cagnetta, A Sellitto, MA Chen, M Hunter, Z Carrasco, R Buggy, JJ Elias, L Matsui, W Treon, SP Richardson, PG Munshi, NC Anderson, KC AF Tai, Yu-Tzu Chang, Betty Y. Kong, Sun-Young Fulciniti, Mariateresa Yang, Guang Calle, Yolanda Hu, Yiguo Lin, Jianhong Zhao, Jian-Jun Cea, Michele Cagnetta, Antonia Sellitto, Michael A. Chen, Michelle Hunter, Zachary Carrasco, Ruben Buggy, Joseph J. Elias, Laurence Matsui, William Treon, Steven P. Richardson, Paul G. Munshi, Nikhil C. Anderson, Kenneth C. TI Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenstrom Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Tai, Yu-Tzu; Kong, Sun-Young; Fulciniti, Mariateresa; Cea, Michele; Cagnetta, Antonia; Munshi, Nikhil C.; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Tai, Yu-Tzu; Kong, Sun-Young; Fulciniti, Mariateresa; Cea, Michele; Cagnetta, Antonia; Munshi, Nikhil C.; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. [Chang, Betty Y.; Elias, Laurence] Pharmacyclics, Res, Sunnyvale, CA USA. [Yang, Guang; Hunter, Zachary] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Calle, Yolanda] Kings Coll London, Dept Haematol Med, London WC2R 2LS, England. [Richardson, Paul G.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. [Buggy, Joseph J.] Pharmacyclics Inc, Sunnyvale, CA USA. [Matsui, William] Johns Hopkins Univ, Sch Med, Div Hematol Malignancies, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 404 EP 404 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101154 ER PT J AU Roccaro, AM Sacco, A Quang, P Azab, A Maiso, P Azab, F Zhang, Y Issa, GC Liu, Y Ngo, HT Kruschinski, A Ghobrial, IM AF Roccaro, Aldo M. Sacco, Antonio Quang, Phong Azab, AbdelKareem Maiso, Patricia Azab, Feda Zhang, Yong Issa, Ghayas C. Liu, Yang Ngo, Hai T. Kruschinski, Anna Ghobrial, Irene M. TI L-Stereoisomer RNA Oligonucleotide Anti-SDF-1 (Nox-A12) Disrupts the Interaction of Multiple Myeloma Cells with the Bone Marrow Milieu In Vivo, Leading to Enhanced Sensitivity to Bortezomib SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Roccaro, Aldo M.; Sacco, Antonio; Quang, Phong; Azab, AbdelKareem; Maiso, Patricia; Azab, Feda; Zhang, Yong; Issa, Ghayas C.; Liu, Yang; Ngo, Hai T.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Kruschinski, Anna] Noxxon Pharma AG, Berlin, Germany. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 405 EP 406 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101158 ER PT J AU Kohno, K Iwasaki, H Iino, T Mizuno, S Sicinski, P Akashi, K AF Kohno, Kentaro Iwasaki, Hiromi Iino, Tadafumi Mizuno, Shin-ichi Sicinski, Peter Akashi, Koichi TI Cyclin A2 Plays a Critical Role in Proliferation of Lymphoid Progenitors SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kohno, Kentaro; Iwasaki, Hiromi; Iino, Tadafumi; Akashi, Koichi] Kyushu Univ Hosp, Ctr Cellular & Mol Med, Fukuoka 812, Japan. [Mizuno, Shin-ichi] Kurume Univ, Sch Med, Dept Med, Div Hematol & Oncol, Kurume, Fukuoka 830, Japan. [Sicinski, Peter] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 417 EP 417 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101185 ER PT J AU Speth, JM Hoggatt, J Pelus, LM AF Speth, Jennifer M. Hoggatt, Jonathan Pelus, Louis M. TI Enhanced Homing of HSPCs After Treatment with Prostaglandin E2 (PGE(2)) May Be An Effect of Transcriptional Regulation of CXC Chemokine Receptor 4 (CXCR4) Through Hypoxia Inducible Factor 1 alpha (HIF1 alpha) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Speth, Jennifer M.; Pelus, Louis M.] Indiana Univ Sch Med, Indianapolis, IN USA. [Hoggatt, Jonathan] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Harvard Stem Cell Inst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 418 EP 419 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101189 ER PT J AU MacLean, GA Menne, TF Park, IH Daley, GQ Orkin, SH AF MacLean, Glenn A. Menne, Tobias F. Park, In-Hyun Daley, George Q. Orkin, Stuart H. TI Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Daley, George Q.] Childrens Hosp Boston, Div Hematol Oncol, Howard Hughes Med Inst, Boston, MA USA. [Daley, George Q.] Childrens Hosp Boston, Howard Hughes Med Inst, Stem Cell Program, Boston, MA USA. [Orkin, Stuart H.] Childrens Hosp Boston, Dana Farber Canc Inst, Dept Pediat Oncol, Harvard Stem Cell Inst,Howard Hughes Med Inst, Boston, MA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 419 EP 420 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101192 ER PT J AU Rosenblatt, J Stone, RM Avivi, I Uhl, L Neuberg, D Joyce, R Tzachanis, D Levine, JD Boussiotis, VA Zwicker, J Arnason, JE Luptakova, K Steensma, DP DeAngelo, DJ Galinsky, I Vasir, B Somaiya, P Mills, H Yuan, YE Bonhoff, J Delaney, C Drummy, N Nicholson, L Stroopinsky, D Held, V Katz, T Bisharat, L Rowe, JM Kufe, D Avigan, D AF Rosenblatt, Jacalyn Stone, Richard M. Avivi, Irit Uhl, Lynne Neuberg, Donna Joyce, Robin Tzachanis, Dimitrios Levine, James D. Boussiotis, Vassiliki A. Zwicker, Jeffrey Arnason, Jon E. Luptakova, Katarina Steensma, David P. DeAngelo, Daniel J. Galinsky, Ilene Vasir, Baldev Somaiya, Poorvi Mills, Heidi Yuan, Yan Emily Bonhoff, Jessica Delaney, Carol Drummy, Natalie Nicholson, Lowell Stroopinsky, Dina Held, Vicki Katz, Tami Bisharat, Lina Rowe, Jacob M. Kufe, Donald Avigan, David TI Clinical Trial Evaluating DC/AML Fusion Cell Vaccination Alone and in Conjunction with PD-1 Blockade in AML Patients Who Achieve a Chemotherapy-Induced Remission SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Rosenblatt, Jacalyn; Uhl, Lynne; Joyce, Robin; Tzachanis, Dimitrios; Levine, James D.; Boussiotis, Vassiliki A.; Zwicker, Jeffrey; Arnason, Jon E.; Luptakova, Katarina; Somaiya, Poorvi; Mills, Heidi; Yuan, Yan Emily; Bonhoff, Jessica; Delaney, Carol; Drummy, Natalie; Stroopinsky, Dina; Avigan, David] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Stone, Richard M.; Neuberg, Donna; Steensma, David P.; DeAngelo, Daniel J.; Galinsky, Ilene; Vasir, Baldev; Nicholson, Lowell; Kufe, Donald] Dana Farber Canc Inst, Boston, MA 02115 USA. [Avivi, Irit; Held, Vicki; Katz, Tami; Bisharat, Lina] Rambam Med Ctr, Haifa, Israel. [Rowe, Jacob M.] Shaare Zedek Med Ctr, Jerusalem, Israel. NR 0 TC 2 Z9 2 U1 1 U2 5 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 432 EP 433 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101219 ER PT J AU Rubenstein, JL Chen, LJ Advani, R Drappatz, J Gerstner, E Batchelor, T Krouwer, H Kadoch, C Munster, P Cha, S Shuman, MA Damon, LE AF Rubenstein, James L. Chen, Lingjing Advani, Ranjana Drappatz, Jan Gerstner, Elizabeth Batchelor, Tracy Krouwer, Hendrikus Kadoch, Cigall Munster, Pamela Cha, Soonmee Shuman, Marc A. Damon, Lloyd E. TI Multicenter Phase I Trial of Intraventricular Immuno-Chemotherapy in Recurrent CNS Lymphoma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Shuman, Marc A.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Advani, Ranjana] Stanford Univ, Stanford, CA 94305 USA. [Drappatz, Jan] Dana Farber Canc Ctr, Boston, MA USA. [Gerstner, Elizabeth; Batchelor, Tracy] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Krouwer, Hendrikus] Med Coll Wisconsin, Milwaukee, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 438 EP 439 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101230 ER PT J AU Zhang, B Ho, YW Holyoake, TL Huettner, CS Bhatia, R AF Zhang, Bin Ho, Yin Wei Holyoake, Tessa L. Huettner, Claudia S. Bhatia, Ravi TI Leukemia-Induced Alterations in Bone Marrow Cytokine and Chemokine Levels Contribute to Altered Stem Cell Lodgment and Impairment of Normal Stem Cell Growth in CML SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Zhang, Bin; Ho, Yin Wei; Bhatia, Ravi] City Hope Natl Med Ctr, Div Hematopoiet Stem Cell & Leukemia Res, Duarte, CA 91010 USA. [Holyoake, Tessa L.] Paul OGorman Leukaemia Res Ctr, Sect Expt Haematol, Gartnavel Gen Hosp, Glasgow, Lanark, Scotland. [Huettner, Claudia S.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 439 EP 440 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101233 ER PT J AU Bejar, R Stevenson, K Caughey, B Abdel-Wahab, O Galili, N Garcia-Manero, G Kantarjian, HM Raza, A Steensma, DP Levine, RL Neuberg, D Ebert, BL AF Bejar, Rafael Stevenson, Kristen Caughey, Bennett Abdel-Wahab, Omar Galili, Naomi Garcia-Manero, Guillermo Kantarjian, Hagop M. Raza, Azra Steensma, David P. Levine, Ross L. Neuberg, Donna Ebert, Benjamin L. TI Validation of a Prognostic Model and the Impact of SF3B1, DNMT3A, and Other Mutations in 289 Genetically Characterized Lower Risk MDS Patient Samples SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Bejar, Rafael; Caughey, Bennett; Ebert, Benjamin L.] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA. [Stevenson, Kristen; Neuberg, Donna] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Abdel-Wahab, Omar; Levine, Ross L.] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA. [Abdel-Wahab, Omar; Levine, Ross L.] Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY 10021 USA. [Galili, Naomi] Columbia Univ, Med Ctr, Irving Canc Res Ctr, New York, NY USA. [Garcia-Manero, Guillermo; Kantarjian, Hagop M.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Raza, Azra] Columbia Presbyterian Med Ctr, New York, NY 10032 USA. NR 0 TC 2 Z9 2 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 443 EP 443 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101240 ER PT J AU Virgilio, M Payne, E Narla, A Sun, H Paw, BH Look, T Ebert, BL Berliner, N Khanna-Gupta, A AF Virgilio, Maria Payne, Elspeth Narla, Anupama Sun, Hong Paw, Barry H. Look, Thomas Ebert, Benjamin L. Berliner, Nancy Khanna-Gupta, Arati TI L-Leucine Improves the Anemia of the 5q-Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Payne, Elspeth] UCL, Inst Canc, London, England. [Narla, Anupama] Childrens Hosp Boston, Boston, MA USA. [Paw, Barry H.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Hematol,Dept Med, Boston, MA 02115 USA. [Look, Thomas] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 443 EP 444 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101241 ER PT J AU Davids, MS Lannutti, BJ Brown, JR Letai, AG AF Davids, Matthew S. Lannutti, Brian J. Brown, Jennifer R. Letai, Anthony G. TI BH3 Profiling Demonstrates That Restoration of Apoptotic Priming Contributes to Increased Sensitivity to PI3K Inhibition in Stroma-Exposed Chronic Lymphocytic Leukemia Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Davids, Matthew S.; Brown, Jennifer R.; Letai, Anthony G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Lannutti, Brian J.] Gilead Sci Inc, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 445 EP 445 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101245 ER PT J AU Naito, M Hainz, U Stevenson, K Alonso, A Matsuoka, K Sasada, T Neuberg, D Ritz, J Freeman, GJ Wu, CJ AF Naito, Masayasu Hainz, Ursula Stevenson, Kristen Alonso, Anselmo Matsuoka, Ken-ichi Sasada, Tesuro Neuberg, Donna Ritz, Jerome Freeman, Gordon J. Wu, Catherine J. TI Ex Vivo Expansion of Donor-Derived Anti-Tumor T Cells for CLL-Specific Adoptive Immunotherapy SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Naito, Masayasu; Hainz, Ursula; Alonso, Anselmo; Sasada, Tesuro; Wu, Catherine J.] Dana Farber Canc Inst, Canc Vaccine Ctr, Boston, MA 02115 USA. [Stevenson, Kristen; Neuberg, Donna] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 447 EP 447 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101249 ER PT J AU Imataki, O Tanaka, M Berezovskaya, A Butler, MO Nadler, LM Hirano, N AF Imataki, Osamu Tanaka, Makito Berezovskaya, Alla Butler, Marcus O. Nadler, Lee M. Hirano, Naoto TI Endogenous Ligands Selectively Stimulate Highly Avid Autoreactive Human Invariant Natural Killer T Cells with Distinctive T-Cell Receptor V beta 11 CDR3 Sequence Motifs SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Imataki, Osamu; Tanaka, Makito; Berezovskaya, Alla; Butler, Marcus O.; Nadler, Lee M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Hirano, Naoto] Ontario Canc Inst, Toronto, ON M4X 1K9, Canada. NR 0 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 456 EP 457 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101270 ER PT J AU Waller, EK Harris, WAC Devine, S Porter, DL Mineishi, S McCarty, JM Gonzalez, CE Spitzer, TR Krijanovski, OI Linenberger, ML Woolfrey, A Howard, A Gurgol, C Logan, BR Confer, DL Anasetti, C AF Waller, Edmund K. Harris, Wayne A. C. Devine, Steven Porter, David L. Mineishi, Shin McCarty, John M. Gonzalez, Corina E. Spitzer, Thomas R. Krijanovski, Oleg I. Linenberger, Michael L. Woolfrey, Ann Howard, Alan Gurgol, Cathy Logan, Brent R. Confer, Dennis L. Anasetti, Claudio TI Larger Numbers of Donor Naive CD8+T-Cells and Plasmacytoid Dendritic Cell Precursors In Allogeneic BM Grafts From Unrelated Donors Are Associated with Improved Survival: Results From BMT CTN 0201 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Waller, Edmund K.] Emory Univ, Winship Canc Inst, Dept Heamtol Med Oncol, Atlanta, GA 30322 USA. [Devine, Steven] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA. [Porter, David L.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Mineishi, Shin] Univ Michigan, Blood & Marrow Transplant Program, Ann Arbor, MI 48109 USA. [McCarty, John M.] Virginia Commonwealth Univ, Med Coll Virginia, VCU Hlth Syst, Richmond, VA 23298 USA. [Gonzalez, Corina E.] Georgetown Univ Hosp, Washington, DC 20007 USA. [Spitzer, Thomas R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Krijanovski, Oleg I.] Sutter E Bay Med Fdn, Berkeley, CA USA. [Linenberger, Michael L.; Woolfrey, Ann] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Howard, Alan; Confer, Dennis L.] Natl Marrow Donor Program, Minneapolis, MN USA. [Gurgol, Cathy] Blood & Marrow Transplant Clin Trials Network, Rockville, MD USA. [Logan, Brent R.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Anasetti, Claudio] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 459 EP 460 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101275 ER PT J AU Sullivan, A Alexander, S Back, A Wilson-Genderson, M Loberiza, FR Tulsky, J Block, S Lee, SJ AF Sullivan, Amy Alexander, Stewart Back, Anthony Wilson-Genderson, Maureen Loberiza, Fausto R., Jr. Tulsky, James Block, Susan Lee, Stephanie J. TI What Predicts Agreement about Prognosis Between Patients and Physicians? SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Sullivan, Amy] Harvard Univ, Sch Med, Boston, MA USA. [Back, Anthony] Univ Washington, Seattle, WA 98195 USA. [Wilson-Genderson, Maureen] Virginia Commonwealth Univ, Dept Social & Behav Hlth, Richmond, VA 23284 USA. [Loberiza, Fausto R., Jr.] Univ Nebraska Med Ctr, Div Hematol Oncol, Omaha, NE USA. [Tulsky, James] Duke Univ, Med Ctr, Ctr Palliat Care, Durham, NC 27706 USA. [Block, Susan] Dana Farber Canc Inst, Dept Psychosocial Oncol & Palliat Care, Boston, MA USA. [Lee, Stephanie J.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 469 EP 469 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101292 ER PT J AU Wear, SM Richardson, PG Revta, C Vij, R Fiala, M Lonial, S Mitchell, AR Siegel, DS Aleman, A Jakubowiak, AJ Durecki, DE Reece, DE Gul, E Chari, A Jagannath, S La, L Hofmeister, CC Bowers, MA Stewart, AK Hagerty, R Wolf, JL Pelle-Day, G Krishnan, A Duarte, L Zimmerman, TM Larsen, D Kumar, S Birgin, A Raje, NS Roy, V Maharaj, M Fay, JW Messing, T Ott, RF Tasca, L Anderson, KC Giusti, K AF Wear, Sandra M. Richardson, Paul G. Revta, Carolyn Vij, Ravi Fiala, Mark Lonial, Sagar Mitchell, Alaina R. Siegel, David S. Aleman, Adolfo Jakubowiak, Andrzej J. Durecki, Diane E. Reece, Donna E. Gul, Engin Chari, Ajai Jagannath, Sundar La, Lisa Hofmeister, Craig C. Bowers, Mindy A. Stewart, A. Keith Hagerty, Rachel Wolf, Jeffrey L. Pelle-Day, Geraldine Krishnan, Amrita Duarte, Lupe Zimmerman, Todd M. Larsen, Daniel Kumar, Shaji Birgin, Ann Raje, Noopur S. Roy, Vivek Maharaj, Michele Fay, Joseph W. Messing, Tracey Ott, Robert F. Tasca, Leah Anderson, Kenneth C. Giusti, Kathy TI The Multiple Myeloma Research Consortium (MMRC): Accelerated Start up and Accrual Metrics Speeds Drug Development SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Wear, Sandra M.; Ott, Robert F.; Tasca, Leah] Multiple Myeloma Res Consortium, Norwalk, CT USA. [Richardson, Paul G.; Revta, Carolyn; Anderson, Kenneth C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Vij, Ravi; Fiala, Mark] Washington Univ, Sch Med, St Louis, MO USA. [Lonial, Sagar; Mitchell, Alaina R.] Emory Univ, Sch Med, Atlanta, GA USA. [Siegel, David S.; Aleman, Adolfo] Hackensack Univ, Med Ctr, Hackensack, NJ USA. [Jakubowiak, Andrzej J.; Durecki, Diane E.] Univ Michigan, Ann Arbor, MI 48109 USA. [Reece, Donna E.; Gul, Engin] Princess Margaret Hosp, Univ Hlth Network, Toronto, ON M4X 1K9, Canada. [Chari, Ajai; Jagannath, Sundar; La, Lisa] Mt Sinai Sch Med, New York, NY USA. [Hofmeister, Craig C.; Bowers, Mindy A.] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA. [Stewart, A. Keith; Hagerty, Rachel] Mayo Clin, Scottsdale, AZ USA. [Wolf, Jeffrey L.; Pelle-Day, Geraldine] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Krishnan, Amrita; Duarte, Lupe] City Hope Natl Med Ctr, Duarte, CA 91010 USA. [Zimmerman, Todd M.; Larsen, Daniel] Univ Chicago, Med Ctr, Chicago, IL 60637 USA. [Kumar, Shaji; Birgin, Ann] Mayo Clin, Rochester, MN USA. [Raje, Noopur S.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Roy, Vivek; Maharaj, Michele] Mayo Clin, Jacksonville, FL 32224 USA. [Fay, Joseph W.; Messing, Tracey] Baylor Univ, Med Ctr, Dallas, TX USA. [Giusti, Kathy] Multiple Myeloma Res Fdn Consortium, Norwalk, CT USA. RI Kumar, Shaji/A-9853-2008 OI Kumar, Shaji/0000-0001-5392-9284 NR 2 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 470 EP 471 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101295 ER PT J AU Sykes, DB Schroyens, WA O'Connell, CL Feinstein, DI Bazari, H Dahl, DM Colvin, RB Paelinck, BP Uppot, RN Op de Beeck, B Boswell, W Raje, NS Harris, NL Attar, EC AF Sykes, David B. Schroyens, Wilfried A. O'Connell, Casey L. Feinstein, Donald I. Bazari, Hasan Dahl, Douglas M. Colvin, Robert B. Paelinck, Bernard P. Uppot, Raul N. Op de Beeck, Bart Boswell, William Raje, Noopur S. Harris, Nancy Lee Attar, Eyal C. TI The TEMPI Syndrome: Telangiectasias, Elevated Erythropoietin and Erythrocytosis, Monoclonal Gammopathy, Perinephric Fluid Collections, and Intrapulmonary Shunting SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Sykes, David B.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA. [Schroyens, Wilfried A.] Univ Antwerp Hosp, Edegem, Belgium. [O'Connell, Casey L.] Univ So Calif, Keck Sch Med, Jane Anne Nohl Div Hematol, Ctr Study Blood Dis,USC Dept Internal Med, Los Angeles, CA 90033 USA. [Paelinck, Bernard P.; Op de Beeck, Bart] Univ Antwerp Hosp, Antwerp, Belgium. [Raje, Noopur S.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA USA. [Attar, Eyal C.] Massachusetts Gen Hosp, Bone Marrow Transplant Unit, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 479 EP 479 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101308 ER PT J AU Jakubowski, JA Zhou, CM Small, DS Winters, KJ Lachno, DR Frelinger, AL Howard, J Jurcevic, S Payne, CD AF Jakubowski, Joseph A. Zhou, Chunmei Small, David S. Winters, Kenneth J. Lachno, D. Richard Frelinger, Andrew L., III Howard, Jo Jurcevic, Stipo Payne, Christopher D. TI A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Effects on In Vivo Markers of Platelet Activation and of Coagulation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Jakubowski, Joseph A.] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA. [Zhou, Chunmei] Eli Lilly & Co, Cardiovasc, Indianapolis, IN 46285 USA. [Lachno, D. Richard] Eli Lilly & Co, Windlesham, Surrey, England. [Frelinger, Andrew L., III] Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Platelet Res Studies,Childrens Hosp Boston, Boston, MA 02115 USA. [Howard, Jo] Guys & St Thomas NHS Trust, London, England. [Jurcevic, Stipo] Kings Coll London, London WC2R 2LS, England. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 483 EP 484 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101320 ER PT J AU Jakubowski, JA Zhou, CM Small, DS Winters, KJ Lachno, R Frelinger, AL Howard, J Jurcevic, S Payne, CD AF Jakubowski, Joseph A. Zhou, Chunmei Small, David S. Winters, Kenneth J. Lachno, Richard Frelinger, Andrew L., III Howard, Jo Jurcevic, Stipo Payne, Christopher D. TI A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Impact on Ex Vivo Platelet Reactivity SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Jakubowski, Joseph A.] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA. [Zhou, Chunmei] Eli Lilly & Co, Cardiovasc, Indianapolis, IN 46285 USA. [Winters, Kenneth J.] Eli Lilly & Co, Windlesham, Surrey, England. [Frelinger, Andrew L., III] Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Platelet Res Studies,Childrens Hosp Boston, Boston, MA 02115 USA. [Howard, Jo] Guys & St Thomas NHS Trust, London, England. [Jurcevic, Stipo] Kings Coll London, London WC2R 2LS, England. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 485 EP 485 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101324 ER PT J AU Pandey, GS Garfield, S Curran, JE Moses, EK Kimchi-Sarfaty, C Yanover, C Howard, TE Sauna, ZE AF Pandey, Gouri Shankar Garfield, Susan Curran, Joanne E. Moses, Eric K. Kimchi-Sarfaty, Chava Yanover, Chen Howard, Tom E. Sauna, Zuben E. TI The Entire Primary Sequence of Factor VIII Is Synthesized As Two Polypeptide Chains in Hemophilia A Patients with the Intron-22-Inversion SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Pandey, Gouri Shankar] US FDA, Lab Hemostasis, DH CBER, Bethesda, MD 20014 USA. [Garfield, Susan] NCI, NIH, Bethesda, MD 20892 USA. [Curran, Joanne E.] SW Fdn Biomed Res, Dept Genet, San Antonio, TX USA. [Kimchi-Sarfaty, Chava; Sauna, Zuben E.] US FDA, Ctr Biol Evaluat & Res, Div Hematol, Bethesda, MD 20892 USA. [Yanover, Chen] Fred Hutchinson Canc Res Ctr, Program Computat Biol, Seattle, WA 98104 USA. [Howard, Tom E.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 531 EP 532 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101445 ER PT J AU Harris, JM Harris, LJ Cox, AG Garnaas, MK Frechette, GM Cortes, M Cutting, CC Dovey, MC Paw, BH Vander Heiden, M Goessling, W North, TE AF Harris, James M. Harris, Lauren J. Cox, Andrew G. Garnaas, Maija K. Frechette, Gregory M. Cortes, Mauricio Cutting, Claire C. Dovey, Michael C. Paw, Barry H. Vander Heiden, Matthew Goessling, Wolfram North, Trista E. TI Metabolism-Induced Reactive Oxygen Species and Hifl alpha-Mediated Gene Regulation Control the Timing and Magnitude of Hematopoietic Stem Cell Induction SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Harris, James M.; Harris, Lauren J.; Frechette, Gregory M.; Cortes, Mauricio; Dovey, Michael C.; North, Trista E.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pathol, Boston, MA 02215 USA. [Cox, Andrew G.; Garnaas, Maija K.; Cutting, Claire C.; Goessling, Wolfram] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA. [Cox, Andrew G.; Garnaas, Maija K.; Cutting, Claire C.; Goessling, Wolfram] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA. [Cox, Andrew G.; Garnaas, Maija K.; Cutting, Claire C.; Goessling, Wolfram] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Paw, Barry H.] Harvard Univ, Brigham & Womens Hosp, Div Hematol, Dept Med,Sch Med, Boston, MA 02115 USA. [Vander Heiden, Matthew] MIT, Koch Inst Canc Res, Cambridge, MA 02139 USA. NR 0 TC 0 Z9 0 U1 1 U2 6 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 565 EP 566 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101535 ER PT J AU Carroll, KJ Dovey, MC Cutting, CC Sheward, LV Harris, JM Goessling, W North, TE AF Carroll, Kelli J. Dovey, Michael C. Cutting, Claire C. Sheward, Lea Vedder Harris, James M. Goessling, Wolfram North, Trista E. TI Hematopoietic Stem Cell Formation in Zebrafish Is Regulated in a Temporally Distinct Manner by Estrogen Receptor SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Carroll, Kelli J.; Dovey, Michael C.; Sheward, Lea Vedder; Harris, James M.; North, Trista E.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pathol, Boston, MA 02215 USA. [Cutting, Claire C.; Goessling, Wolfram] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA. [Cutting, Claire C.; Goessling, Wolfram] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA. [Cutting, Claire C.; Goessling, Wolfram] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 566 EP 567 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101537 ER PT J AU Dao, KHT Rotelli, MD Petersen, CL Brown, BR Nelson, WD Yates, JE Newell, AH Olson, SB Druker, BJ Bagby, GC AF Dao, Kim-Hien T. Rotelli, Michael D. Petersen, Curtis L. Brown, Brie R. Nelson, Whitney D. Yates, Jane E. Newell, Amy Hanlon Olson, Susan B. Druker, Brian J. Bagby, Grover C., Jr. TI FANCL Ubiquitinates Beta-Catenin and Enhances Its Nuclear Function SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Dao, Kim-Hien T.; Rotelli, Michael D.; Petersen, Curtis L.; Brown, Brie R.; Nelson, Whitney D.] Oregon Hlth & Sci Univ, Ctr Hematol Malignancies, Knight Canc Inst Hematol Oncol, Portland, OR 97201 USA. [Yates, Jane E.] NW VA Canc Res Ctr, Portland, OR USA. [Druker, Brian J.] Oregon Hlth & Sci Univ, Knight Canc Inst, Howard Hughes Med Inst, Portland, OR 97201 USA. [Bagby, Grover C., Jr.] Portland VA Med Ctr, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 588 EP 589 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101604 ER PT J AU Yan, CT Park, JH Muniandy, P Troppito, L Welner, R AF Yan, Catherine T. Park, Ji Hye Muniandy, Parames Troppito, Logan Welner, Robert TI Lig4 R278H Mutation Impacts on LT-HSC Functions, Cancer Development and Aging SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Yan, Catherine T.; Muniandy, Parames; Troppito, Logan] Harvard Univ, Sch Med, BIDMC, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 594 EP 594 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101619 ER PT J AU Faber, K Bullinger, L Garding, A Mertens, D Martin, D Walcher, D Dohner, K Doehner, H Sykes, SM Claus, R Plass, C Lane, SW Scholl, C Frohling, S AF Faber, Katrin Bullinger, Lars Garding, Angela Mertens, Daniel Martin, Daniela Walcher, Daniel Doehner, Konstanze Doehner, Hartmut Sykes, Stephen M. Claus, Rainer Plass, Christoph Lane, Steven W. Scholl, Claudia Froehling, Stefan TI Myeloid Leukemogenesis Driven by Aberrant CDX2 Expression Involves Transcriptional Repression of KLF4 and Deregulated PPAR gamma Signaling SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Faber, Katrin; Bullinger, Lars; Garding, Angela; Mertens, Daniel; Martin, Daniela; Doehner, Konstanze; Doehner, Hartmut; Scholl, Claudia; Froehling, Stefan] Univ Ulm, Dept Internal Med 3, D-7900 Ulm, Germany. [Walcher, Daniel] Univ Ulm, Dept Internal Med 2, D-7900 Ulm, Germany. [Sykes, Stephen M.] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA. [Claus, Rainer; Plass, Christoph] German Canc Res Ctr, Div Epigen & Canc Risk Factors, D-6900 Heidelberg, Germany. [Lane, Steven W.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. RI Plass, Christoph/H-7192-2014 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 595 EP 596 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597101624 ER PT J AU Mulligan, G Lichter, DI Di Bacco, A Blakemore, SJ Berger, A Koenig, E Bernard, H Trepicchio, WL Li, B Lonial, S Richardson, PG Anderson, KC Sonneveld, P San Miguel, JF Esseltine, DL Schu, M AF Mulligan, George Lichter, David I. Di Bacco, Alessandra Blakemore, Stephen J. Berger, Allison Koenig, Erik Bernard, Hugues Trepicchio, William L. Li, Bin Lonial, Sagar Richardson, Paul G. Anderson, Kenneth C. Sonneveld, Pieter San Miguel, Jesus F. Esseltine, Dixie-Lee Schu, Matthew TI Mutational Analysis of Tumor Samples From Patients with Relapsed or Refractory Multiple Myeloma (MM) Highlights the Prevalence of RAS/RAF Pathway Activation and Demonstrates Previously Unreported Mutations in Known Cancer Genes SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Berger, Allison] Millennium Pharmaceut Inc, Discovery, Cambridge, MA USA. [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Sonneveld, Pieter] Erasmus MC, Dept Hematol, Rotterdam, Netherlands. [San Miguel, Jesus F.] Hosp Clin Univ, Salamanca, Spain. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 603 EP 603 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101646 ER PT J AU Kentsis, A Sanda, T Reed, C Rodig, SJ Tholouli, E Ngo, V Kutok, JL Dahlberg, SE Moreau, LA Woude, GV Christensen, J Byers, R Kung, AL Staudt, LM Look, T AF Kentsis, Alex Sanda, Takaomi Reed, Casie Rodig, Scott J. Tholouli, Eleni Vu Ngo Kutok, Jeffery Lorne Dahlberg, Suzanne E. Moreau, Lisa A. Woude, George Vande Christensen, James Byers, Richard Kung, Andrew L. Staudt, Louis M. Look, Thomas TI Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kentsis, Alex; Sanda, Takaomi] Harvard Univ, Sch Med, Dana Farber Canc Inst, Childrens Hosp Boston, Boston, MA 02115 USA. [Kutok, Jeffery Lorne] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Tholouli, Eleni; Byers, Richard] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England. [Dahlberg, Suzanne E.] Dana Farber Canc Inst, Dept Biostat Sci, Boston, MA 02115 USA. [Woude, George Vande] Van Andel Res Inst, Grand Rapids, MI USA. [Christensen, James] Pfizer, San Diego, CA USA. [Kung, Andrew L.] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Staudt, Louis M.] NCI, Metab Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 612 EP 612 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597101673 ER PT J AU Issa, GC Delmore, JE McKeown, MR Lemieux, ME Rahl, PB Jacobs, HM Kastritis, E Gilpatrick, T Paranal, RM Qi, J Shi, JW Chesi, M Schinzel, AC Vakoc, CR Bergsagel, PL Richardson, PG Young, R Hahn, WC Ghobrial, IM Anderson, KC Kung, AL Mitsiades, CS Bradner, JE AF Issa, Ghayas C. Delmore, Jake E. McKeown, Michael R. Lemieux, Madeleine E. Rahl, Peter B. Jacobs, Hannah M. Kastritis, Efstathios Gilpatrick, Timothy Paranal, Ronald M. Qi, Jun Shi, Junwei Chesi, Marta Schinzel, Anna C. Vakoc, Christopher R. Bergsagel, P. Leif Richardson, Paul G. Young, Richard Hahn, William C. Ghobrial, Irene M. Anderson, Kenneth C. Kung, Andrew L. Mitsiades, Constantine S. Bradner, James E. TI Inhibition of c-Myc Expression and Function in Hematologic Malignancies SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Rahl, Peter B.; Young, Richard] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Shi, Junwei; Vakoc, Christopher R.] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA. [Chesi, Marta; Bergsagel, P. Leif] Mayo Clin Arizona, Div Hematol Oncol, Scottsdale, AZ USA. [Kung, Andrew L.] Lurie Family Imaging Ctr, Boston, MA USA. [Kung, Andrew L.] Childrens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 613 EP 614 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102004 ER PT J AU Zhao, JJ Chu, ZB Lin, JH Tai, YT Munshi, NC Anderson, KC Carrasco, R AF Zhao, Jian-Jun Chu, Zhangbo Lin, Jianhong Tai, Yu-Tzu Munshi, Nikhil C. Anderson, Kenneth C. Carrasco, Ruben TI Mir-222-221 Induce Dexamethasone Resistance by Targeting BBC3/PUMA in Human Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Tai, Yu-Tzu] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. [Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 617 EP 617 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102014 ER PT J AU Davids, MS Vartanov, AR Werner, L Neuberg, D Dal Cin, P Brown, JR AF Davids, Matthew S. Vartanov, Alexander R. Werner, Lillian Neuberg, Donna Dal Cin, Paola Brown, Jennifer R. TI Rearrangement of 14q32 in the Absence of t(14;18) Is Associated with Short Time to First Treatment in Chronic Lymphocytic Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Davids, Matthew S.; Vartanov, Alexander R.; Brown, Jennifer R.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Dal Cin, Paola] Brigham & Womens Hosp, Ctr Adv Mol Diagnost, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 625 EP 625 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102033 ER PT J AU Chonghaile, TN Sarosiek, K Ryan, J Moore, VDG Tai, YT Richardson, PG Anderson, KC Stone, RM DeAngelo, DJ Mitsiades, CS Sallan, SE Hirsch, M Silverman, LB Carrasco, R Letai, AG AF Chonghaile, Triona Ni Sarosiek, Kristopher Ryan, Jeremy Moore, Vicki Del Gaizo Tai, Yu-Tzu Richardson, Paul G. Anderson, Kenneth C. Stone, Richard M. DeAngelo, Daniel J. Mitsiades, Constantine S. Sallan, Stephen E. Hirsch, Michelle Silverman, Lewis B. Carrasco, Ruben Letai, Anthony G. TI Mitochondrial Apoptotic Priming Measured by BH3 Profiling Regulates Clinical Response to Chemotherapy in Myeloma and Acute Lymphoblastic Leukemia and Explains Therapeutic Index SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Richardson, Paul G.; Letai, Anthony G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Moore, Vicki Del Gaizo] Elon Univ, Dept Chem, Elon, NC USA. [Tai, Yu-Tzu] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Tai, Yu-Tzu] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. [Mitsiades, Constantine S.] Harvard Univ, Sch Med, Dana Farber Canc Inst,Dept Med Oncol, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. [Sallan, Stephen E.; Silverman, Lewis B.] Childrens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. [Hirsch, Michelle] Brigham & Womens Hosp, Boston, MA 02115 USA. RI Ni Chonghaile, Triona/L-9418-2015 OI Ni Chonghaile, Triona/0000-0002-3041-4031 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 626 EP 627 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102037 ER PT J AU Newell, LF Othus, M Walter, RB Petergdorf, SH Chauncey, T Anderson, JE Godwin, JE Kopecky, KJ Appelbaum, FR Estey, EH AF Newell, Laura F. Othus, Megan Walter, Roland B. Petergdorf, Stephen H. Chauncey, Thomas Anderson, Jeanne E. Godwin, John E. Kopecky, Kenneth J. Appelbaum, Frederick R. Estey, Elihu H. TI Prognostic Import of French-American-British (FAB) System As Embedded in 2008 Revision of World Health Organization Classification of AML: Review of SWOG Data SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Newell, Laura F.; Walter, Roland B.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA. [Petergdorf, Stephen H.; Chauncey, Thomas; Estey, Elihu H.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. [Chauncey, Thomas] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Anderson, Jeanne E.] Katmai Oncol Grp, Anchorage, AK USA. [Godwin, John E.] So Illinois Univ, Simmons Canc Inst, Div Hematol Oncol, Springfield, IL USA. [Kopecky, Kenneth J.] Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98104 USA. RI Walter, Roland/C-1064-2008 OI Walter, Roland/0000-0002-9268-3341 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 628 EP 629 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102041 ER PT J AU Ma, WX Smith, KM Gutierrez, A Leu, HS Jiang, QF Wu, CCN Shih, AY Court-Recart, AC Sadarangani, A Goff, DJ Wei, P Look, AT Jamieson, CHM AF Ma, Wenxue Smith, Kristen M. Gutierrez, Alejandro Leu, Heather S. Jiang, Qingfei Wu, Christina C. N. Shih, Alice Y. Court-Recart, Angela C. Sadarangani, Anil Goff, Daniel J. Wei, Ping Look, A. Thomas Jamieson, Catriona H. M. TI NOTCH1 Signaling Defines a Leukemia Initiating Cell Population in T-Cell Acute Lymphoblastic Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ma, Wenxue; Smith, Kristen M.; Leu, Heather S.; Jiang, Qingfei; Wu, Christina C. N.; Shih, Alice Y.; Court-Recart, Angela C.; Sadarangani, Anil; Jamieson, Catriona H. M.] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. [Gutierrez, Alejandro] Childrens Hosp, Boston, MA 02115 USA. [Gutierrez, Alejandro; Look, A. Thomas] Dana Farber Canc Inst, Boston, MA 02115 USA. [Wei, Ping] Pfizer Inc, Drug Discovery & Oncol Res Unit, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 653 EP 654 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102102 ER PT J AU Ravandi, F Pigneux, A DeAngelo, DJ Dombret, H Delaunay, J Thomas, X Kadia, T Luepfert, C Asatiani, E Donica, M Kantarjian, HM Smith, BD AF Ravandi, Farhad Pigneux, Arnaud DeAngelo, Daniel J. Dombret, Herve Delaunay, Jacques Thomas, Xavier Kadia, Tapan Luepfert, Christian Asatiani, Ekaterine Donica, Margarita Kantarjian, Hagop M. Smith, B. Douglas TI Preliminary Clinical, Pharmacokinetic (PK) and Pharmacodynamic (PD) Results of the Safety Run-In Part of a Phase II Trial of Orally Available MEK-Inhibitor MSC1936369 in Patients (Pts) with Advanced Hematological Malignancies (HM) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ravandi, Farhad; Kadia, Tapan; Kantarjian, Hagop M.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Pigneux, Arnaud] Hop Haut Leveque, Pessac, France. [DeAngelo, Daniel J.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Dombret, Herve] Hop St Louis, AP HP, Paris, France. [Delaunay, Jacques] Hop Hotel Dieu, Nantes, France. [Thomas, Xavier] Univ Lyon 2, HCL, Hop Edouard Herriot, Lyon, France. [Luepfert, Christian] Merck KGaA, Darmstadt, Germany. [Asatiani, Ekaterine; Donica, Margarita] Merck Serono SA, Geneva, Switzerland. [Smith, B. Douglas] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 675 EP 676 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102149 ER PT J AU Advani, RH Hong, FX Li, HL Kahl, BS Pfreundschuh, M Ziepert, M AF Advani, Ranjana H. Hong, Fangxin Li, Hailun Kahl, Brad S. Pfreundschuh, Michael Ziepert, Marita TI Validation of the Elderly IPI (E-IPI) for Patients with Diffuse Large B Cell Lymphoma Using An Independent Data Set From the RICOVER-60 Trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Advani, Ranjana H.] Stanford Univ, Med Ctr, Stanford, CA 94305 USA. [Hong, Fangxin; Li, Hailun] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Kahl, Brad S.] Univ Wisconsin, Dept Med Hematol Oncol, Madison, WI USA. [Pfreundschuh, Michael] Univ Saarland, D-6650 Homburg, Germany. [Ziepert, Marita] Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 681 EP 681 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102163 ER PT J AU Mahindra, AK Sohani, AR Toomey, CE Michaelson, JS Barnes, JA Abramson, JS Takvorian, R Raje, NS Hochberg, EP AF Mahindra, Anuj K. Sohani, Aliyah R. Toomey, Christiana E. Michaelson, James S. Barnes, Jeffrey A. Abramson, Jeremy S. Takvorian, Ronald Raje, Noopur S. Hochberg, Ephraim P. TI B Cell Lymphoma In Association with Multiple Myeloma: Analysis of the Biologic Relationship SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Mahindra, Anuj K.; Toomey, Christiana E.; Barnes, Jeffrey A.; Abramson, Jeremy S.; Hochberg, Ephraim P.] Massachusetts Gen Hosp, Ctr Canc, Ctr Lymphoma, Boston, MA USA. [Sohani, Aliyah R.; Michaelson, James S.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Hochberg, Ephraim P.] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 691 EP 691 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102185 ER PT J AU Abramson, JS Hellmann, MD Feng, Y Barnes, JA Takvorian, T Toomey, CE Sheppard, M Michaelson, JS Neuberg, D Hochberg, EP AF Abramson, Jeremy S. Hellmann, Matthew D. Feng, Yang Barnes, Jeffrey A. Takvorian, Tak Toomey, Christiana E. Sheppard, Michael Michaelson, James S. Neuberg, Donna Hochberg, Ephraim P. TI High Rate of Initial Treatment Failure in Patients with Primary Mediastinal B-Cell Lymphoma Treated with R-CHOP SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Abramson, Jeremy S.; Hellmann, Matthew D.; Barnes, Jeffrey A.; Takvorian, Tak; Toomey, Christiana E.; Sheppard, Michael; Hochberg, Ephraim P.] Massachusetts Gen Hosp, Ctr Canc, Ctr Lymphoma, Boston, MA USA. [Feng, Yang; Neuberg, Donna] Dana Farber Canc Inst, Boston, MA 02115 USA. [Michaelson, James S.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 695 EP 696 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102196 ER PT J AU Advani, R Hong, FX Gordon, LI Gascoyne, RD Wagner, H Hoppe, RT Fisher, RI Bartlett, NL Kahl, BS Stiff, P Cheson, BD Belch, AR Friedberg, JW Kassis, J Blum, KA Habermann, TM Tuscano, J Horning, SJ AF Advani, Ranjana Hong, Fangxin Gordon, Leo I. Gascoyne, Randy D. Wagner, Henry Hoppe, Richard T. Fisher, Richard I. Bartlett, Nancy L. Kahl, Brad S. Stiff, Patrick Cheson, Bruce D. Belch, Andrew R. Friedberg, Jonathan W. Kassis, Jeannine Blum, Kristie A. Habermann, Thomas M. Tuscano, Joseph Horning, Sandra J. TI Patterns of Failure in Patients with Stage I/II Bulky Mediastinal Hodgkin Lymphoma (HL) Treated with ABVD plus Radiotherapy or the Stanford V Regimen in the Randomized Phase III North American Intergroup Trial: E2496 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Advani, Ranjana] Stanford Univ, Med Ctr, Stanford, CA 94305 USA. [Hong, Fangxin] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Gordon, Leo I.] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. [Gordon, Leo I.] Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA. [Gascoyne, Randy D.] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada. [Wagner, Henry] Penn State Canc Inst, Hershey, PA USA. [Hoppe, Richard T.; Friedberg, Jonathan W.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Fisher, Richard I.] Univ Rochester, James P Wilmot Cancer Ctr, Rochester, NY USA. [Bartlett, Nancy L.] Washington Univ, Sch Med, St Louis, MO USA. [Kahl, Brad S.] Univ Wisconsin, Dept Med Hematol Oncol, Madison, WI USA. [Stiff, Patrick] Loyola Univ, Maywood, IL 60153 USA. [Cheson, Bruce D.] Georgetown Univ Hosp, Lombardi Comprehens Canc Ctr, Div Hematol & Oncol, Washington, DC 20007 USA. [Belch, Andrew R.] Univ Alberta, Edmonton, AB, Canada. [Belch, Andrew R.] Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada. [Kassis, Jeannine] Hop Maison Neuve Rosemont, Montreal, PQ H1T 2M4, Canada. [Blum, Kristie A.] Ohio State Univ, Columbus, OH 43210 USA. [Habermann, Thomas M.] Mayo Clin, Div Hematol, Rochester, MN USA. [Tuscano, Joseph] UC Davis Canc Ctr, Sacramento, CA USA. [Horning, Sandra J.] Genentech Inc, Clin Dev Hem Onc, San Francisco, CA 94080 USA. RI Blum, Kristie/E-2768-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 696 EP 697 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102198 ER PT J AU Barnes, JA Jacobsen, E Feng, Y Freedman, AS Hochberg, EP LaCasce, AS Armand, P Joyce, R Neuberg, D Fisher, DC Abramson, JS AF Barnes, Jeffrey A. Jacobsen, Eric Feng, Yang Freedman, Arnold S. Hochberg, Ephraim P. LaCasce, Ann S. Armand, Philippe Joyce, Robin Neuberg, Donna Fisher, David C. Abramson, Jeremy S. TI Everolimus in Combination with Rituximab Induces Complete Responses in Heavily Pretreated Diffuse Large B-Cell Lymphoma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Barnes, Jeffrey A.; Hochberg, Ephraim P.; Abramson, Jeremy S.] Massachusetts Gen Hosp, Ctr Canc, Ctr Lymphoma, Boston, MA USA. [Jacobsen, Eric; Feng, Yang; Freedman, Arnold S.; LaCasce, Ann S.; Armand, Philippe; Neuberg, Donna; Fisher, David C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Joyce, Robin] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 710 EP 711 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102230 ER PT J AU Treon, SP Hunter, Z Hanzis, C Tripsas, C Ioakimidis, L Patterson, C Manning, R Sheehy, P Turnbull, B AF Treon, Steven P. Hunter, Zachary Hanzis, Christina Tripsas, Christina Ioakimidis, Leukothea Patterson, Christopher Manning, Robert Sheehy, Patricia Turnbull, Barry TI Treatment with a Bortezomib-Containing Regimen Is Associated with Better Therapeutic Outcomes in Patients with Waldenstrom's Macroglobulinemia Who Have Familial Disease Predisposition SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Treon, Steven P.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Hunter, Zachary; Hanzis, Christina; Tripsas, Christina; Ioakimidis, Leukothea; Patterson, Christopher; Manning, Robert; Sheehy, Patricia] Bing Ctr Waldenstroms Macroglobulinemia, Dana Farber Canc Inst, Boston, MA USA. [Turnbull, Barry] BioBridges Inc, Needham, MA USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 714 EP 714 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102238 ER PT J AU Krause, DS Fulzele, K Catic, A Hurley, M Lezeau, S Hasserjian, R Wu, J Divieti-Pajevic, P Van Etten, RA Schipani, E Scadden, DT AF Krause, Daniela S. Fulzele, Keertik Catic, Andre Hurley, Michael Lezeau, Sanon Hasserjian, Robert Wu, Joy Divieti-Pajevic, Paola Van Etten, Richard A. Schipani, Ernestina Scadden, David T. TI Parathyroid Hormone-Induced Modulation of the Bone Marrow Microenvironment Reduces Leukemic Stem Cells in Murine Chronic Myelogenous-Leukemia-Like Disease Via a TGFbeta-Dependent Pathway SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Krause, Daniela S.; Catic, Andre; Hurley, Michael; Lezeau, Sanon] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA. [Fulzele, Keertik; Wu, Joy; Divieti-Pajevic, Paola; Schipani, Ernestina] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA. [Hasserjian, Robert] Massachusetts Gen Hosp, Dept Pathol WRN 244, Boston, MA 02114 USA. [Van Etten, Richard A.] Tufts Med Ctr, Boston, MA USA. [Scadden, David T.] Harvard Stem Cell Inst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 725 EP 726 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102265 ER PT J AU Azab, F Azab, AK Maiso, P Quang, P Ngo, HT Sacco, A Liu, Y Zhang, Y Reagan, M Roccaro, AM Ghobrial, IM AF Azab, Feda Azab, Abdel Kareem Maiso, Patricia Phong Quang Ngo, Hai T. Sacco, Antonio Liu, Yang Zhang, Yong Reagan, Michaela Roccaro, Aldo M. Ghobrial, Irene M. TI The Role of PI3K Signaling in Cell Trafficking of Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Azab, Feda; Azab, Abdel Kareem; Maiso, Patricia; Ngo, Hai T.; Sacco, Antonio; Liu, Yang; Zhang, Yong; Reagan, Michaela; Roccaro, Aldo M.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Reagan, Michaela/E-3549-2017 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 788 EP 788 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102399 ER PT J AU Shammas, M Pal, J Vahia, AV Nanjappa, P Munshi, MN Shi, JL Munshi, NC AF Shammas, Masood Pal, Jagannath Vahia, Ankit V. Nanjappa, Puru Munshi, Manit N. Shi, Jialan Munshi, Nikhil C. TI Elevated APEX1 Endonuclease Is Associated with Increased DNA Breaks and Instability in Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Shammas, Masood; Vahia, Ankit V.; Nanjappa, Puru; Munshi, Manit N.; Munshi, Nikhil C.] Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. [Pal, Jagannath; Shi, Jialan] VA Hlth Care Syst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 788 EP 788 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102400 ER PT J AU Song, WH Hu, YG Yang, G Shah, PK Shan, WS Tai, YT Li, Y Minvielle, S Avet-Loiseau, H Anderson, KC Li, C Munshi, NC AF Song, Weihua Hu, Yiguo Yang, Guang Shah, Parantu K. Shan, Weisong Tai, Yu-Tzu Li, Yi Minvielle, Stephane Avet-Loiseau, Herve Anderson, Kenneth C. Li, Cheng Munshi, Nikhil C. TI Alternate Splicing Factor Fox2 Affects Growth and Survival of Multiple Myeloma Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Song, Weihua; Hu, Yiguo; Yang, Guang; Shah, Parantu K.; Tai, Yu-Tzu; Li, Yi; Anderson, Kenneth C.; Li, Cheng; Munshi, Nikhil C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Shan, Weisong] McGill Univ, Montreal, PQ, Canada. [Minvielle, Stephane; Avet-Loiseau, Herve] CHU Nantes, F-44035 Nantes 01, France. RI Minvielle, Stephane/K-8251-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 790 EP 790 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102405 ER PT J AU Avet-Loiseau, H Bignell, GR Li, C Magrangeas, F Facon, T Attal, M Anderson, KC Campbell, P Minvielle, S Munshi, NC Futreal, A AF Avet-Loiseau, Herve Bignell, Graham R. Li, Cheng Magrangeas, Florence Facon, Thierry Attal, Michel Anderson, Kenneth C. Campbell, Peter Minvielle, Stephane Munshi, Nikhil C. Futreal, Andrew TI Gene Mutations Detected by Whole-Exome Sequencing and Recurrent Cytogenetic Abnormalities Are Independent Events in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Avet-Loiseau, Herve; Minvielle, Stephane] CHU Nantes, F-44035 Nantes 01, France. [Bignell, Graham R.; Futreal, Andrew] Wellcome Trust Sanger Inst, Cambridge, England. [Li, Cheng] Dana Farber Canc Inst, Boston, MA 02115 USA. [Magrangeas, Florence] Univ Nantes, Ctr Hosp Univ Nantes, UMGC, Lab Hematol,INSERM,U892, Nantes, France. [Facon, Thierry] CHRU, Hop Huriez, Serv Malad Sang, Lille, France. [Attal, Michel] Hop Purpan, Hematol Clin, Toulouse, France. [Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. [Campbell, Peter] Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge, England. RI FACON, THIERRY/M-9736-2014; Magrangeas, Florence/L-3080-2015; Minvielle, Stephane/K-8251-2015 OI FACON, THIERRY/0000-0001-7705-8460; NR 0 TC 0 Z9 0 U1 0 U2 5 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 792 EP 793 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102411 ER PT J AU Morgan, B Azab, F Sacco, A Reagan, M Ngo, HT Liu, Y Zhang, Y Lin, C Roccaro, AM Rommel, C Ghobrial, IM AF Morgan, Brittany Azab, Feda Sacco, Antonio Reagan, Michaela Ngo, Hai T. Liu, Yang Zhang, Yong Lin, Charles Roccaro, Aldo M. Rommel, Christian Ghobrial, Irene M. TI Role of TORC1 and TORC2 in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Morgan, Brittany; Azab, Feda; Sacco, Antonio; Reagan, Michaela; Ngo, Hai T.; Liu, Yang; Zhang, Yong; Roccaro, Aldo M.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Rommel, Christian] Intellikine, La Jolla, CA USA. [Lin, Charles] Massachusetts Gen Hosp, Boston, MA 02114 USA. RI Reagan, Michaela/E-3549-2017 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 792 EP 792 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102410 ER PT J AU Eda, H Santo, L Cirstea, DD Pozzi, S Canavese, M Scullen, TA Vallet, S Raje, NS AF Eda, Homare Santo, Loredana Cirstea, Diana D. Pozzi, Samantha Canavese, Miriam Scullen, Tyler A. Vallet, Sonia Raje, Noopur S. TI Increased Sclerostin Secretion in Multiple Myeloma Results in Stimulation of Osteoclastogenesis and Inhibition of Osteoblastogenesis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Eda, Homare; Santo, Loredana; Pozzi, Samantha; Canavese, Miriam; Scullen, Tyler A.; Vallet, Sonia; Raje, Noopur S.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc, Boston, MA USA. [Cirstea, Diana D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. RI Pozzi, Samantha/A-7617-2012 OI Pozzi, Samantha/0000-0001-7917-1774 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 793 EP 794 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102414 ER PT J AU Hayes, CA Dowling, P Negri, J Henry, M Buon, L Jakubikova, J Delmore, JE McMillin, DW Klippel, S Jacobs, HM van de Donk, NWCJ Dhimolea, E Lawasut, P Richardson, PG Anderson, KC Clynes, M Gorman, PO Mitsiades, CS AF Hayes, Catriona A. Dowling, Paul Negri, Joseph Henry, Michael Buon, Leutz Jakubikova, Jana Delmore, Jake E. McMillin, Douglas W. Klippel, Steffen Jacobs, Hannah M. van de Donk, Niels W. C. J. Dhimolea, Eugen Lawasut, Panisinee Richardson, Paul G. Anderson, Kenneth C. Clynes, Martin Gorman, Peter O. Mitsiades, Constantine S. TI Proteomic Characterization of An Isogenic Multiple Myeloma Cell Line Model of Bortezomib Resistance SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Dowling, Paul; Henry, Michael; Clynes, Martin] Dublin City Univ, Natl Inst Cellular Biothchnol, Dublin 9, Ireland. [Negri, Joseph] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. [Jakubikova, Jana] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Jakubikova, Jana] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. [Gorman, Peter O.] Mater Misericordiae Univ Hosp, Dept Haematol, Dublin 7, Ireland. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 794 EP 794 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102415 ER PT J AU van de Donk, NWCJ Lokhorst, HM Emmelot, M Aarts-Riemens, T McMillin, DW Gorgun, G Klippel, S Dhimolea, E Jakubikova, J Hayes, CA Lawasut, P Delmore, JE Munshi, NC Richardson, PG Anderson, KC Mitsiades, CS Mutis, T AF van de Donk, Niels W. C. J. Lokhorst, Henk M. Emmelot, Maarten Aarts-Riemens, Tineke McMillin, Douglas W. Gorgun, Gullu Klippel, Steffen Dhimolea, Eugen Jakubikova, Jana Hayes, Catriona A. Lawasut, Panisinee Delmore, Jake E. Munshi, Nikhil C. Richardson, Paul G. Anderson, Kenneth C. Mitsiades, Constantine S. Mutis, Tuna TI Proteasome Inhibitors Sensitize Myeloma Cells to T Cell-Mediated Killing SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lawasut, Panisinee; Mitsiades, Constantine S.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Lokhorst, Henk M.; Emmelot, Maarten; Aarts-Riemens, Tineke; Mutis, Tuna] Univ Med Ctr Utrecht, Utrecht, Netherlands. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 800 EP 801 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102433 ER PT J AU Chauhan, D Singh, AV Ray, A Hideshima, T Richardson, PG Palladino, MA Anderson, KC AF Chauhan, Dharminder Singh, Ajita V. Ray, Arghya Hideshima, Teru Richardson, Paul G. Palladino, Michael A. Anderson, Kenneth C. TI A Novel Acanthoic Acid Analog NPI-1342 Blocks I kappa B Kinase-alpha and Trigger In Vitro and In Vivo cytotoxicity in Multiple Myeloma Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Chauhan, Dharminder] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Chauhan, Dharminder] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. [Palladino, Michael A.] Nereus Pharmaceut Inc, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 802 EP 802 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102436 ER PT J AU Roccaro, AM Sacco, A Kuhne, M Azab, A Maiso, P Zhang, Y Liu, Y Azab, F Issa, GC Quang, P Ngo, HT Pan, C Choen, L Cardarelli, PM Ghobrial, IM AF Roccaro, Aldo M. Sacco, Antonio Kuhne, Michelle Azab, AbdelKareem Maiso, Patricia Zhang, Yong Liu, Yang Azab, Feda Issa, Ghayas C. Quang, Phong Ngo, Hai T. Pan, Chin Choen, Lew Cardarelli, Pina M. Ghobrial, Irene M. TI The New CXCR4 Inhibitor MDX-1338 Exerts Anti-Tumor Activity in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Roccaro, Aldo M.; Sacco, Antonio; Azab, AbdelKareem; Maiso, Patricia; Zhang, Yong; Liu, Yang; Azab, Feda; Issa, Ghayas C.; Quang, Phong; Ngo, Hai T.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Kuhne, Michelle; Pan, Chin; Cardarelli, Pina M.] Bristol Myers Squibb Co, Biol Discovery Calif, New York, NY 10154 USA. [Choen, Lew] Bristol Myers Squibb Co, Dept Discovery Med, New York, NY 10154 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 803 EP 803 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102439 ER PT J AU Vogl, DT Stadtmauer, EA Bradner, J Davis, L Paul, TM Scott, EC Nichols, CW Porter, DL Carroll, M Kaplan, J Mallon, G Swider, CR Mangan, PA Shelly, BK Amaravadi, RK AF Vogl, Dan T. Stadtmauer, Edward A. Bradner, James Davis, Lisa Paul, Thomas M. Scott, Emma C. Nichols, Charles W. Porter, David L. Carroll, Martin Kaplan, Janeen Mallon, Gayle Swider, Cezary R. Mangan, Patricia A. Shelly, Brenda K. Amaravadi, Ravi K. TI Combined Autophagy and Proteasome Inhibition for Multiple Myeloma: Final Results of a Phase 1 Trial of Hydroxychloroquine and Standard Dose Bortezomib for Patients with Relapsed or Refractory Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Vogl, Dan T.; Stadtmauer, Edward A.; Paul, Thomas M.; Scott, Emma C.; Porter, David L.; Carroll, Martin; Kaplan, Janeen; Mallon, Gayle; Swider, Cezary R.; Mangan, Patricia A.; Shelly, Brenda K.; Amaravadi, Ravi K.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Bradner, James] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. [Davis, Lisa] Univ Sci Philadelphia, Dept Pharmaceut Sci, Philadelphia, PA USA. [Nichols, Charles W.] Univ Penn, Dept Ophthalmol, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 815 EP 815 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102464 ER PT J AU Ghobrial, IM Banwait, R Azab, AK Quang, P Laubach, JP Donovan, A Bagshaw, M Armand, P Munshi, NC Schlossman, RL Chuma, S Kunsman, J Warren, D Anderson, KC Richardson, PG AF Ghobrial, Irene M. Banwait, Ranjit Azab, Abdel Kareem Phong Quang Laubach, Jacob P. Donovan, Amanda Bagshaw, Meghan Armand, Philippe Munshi, Nikhil C. Schlossman, Robert L. Chuma, Stacey Kunsman, Janet Warren, Diane Anderson, Kenneth C. Richardson, Paul G. TI Phase I Trial of Plerixafor and Bortezomib As a Chemosensitization Strategy in Relapsed or Relapsed/Refractory Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ghobrial, Irene M.; Banwait, Ranjit; Azab, Abdel Kareem; Phong Quang; Laubach, Jacob P.; Donovan, Amanda; Bagshaw, Meghan; Munshi, Nikhil C.; Schlossman, Robert L.; Chuma, Stacey; Kunsman, Janet; Warren, Diane; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Armand, Philippe] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 817 EP 818 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102469 ER PT J AU Gimsing, P Plesner, T Nahi, H Lokhorst, H Valentin, ML Lisby, S Richardson, PG AF Gimsing, Peter Plesner, Torben Nahi, Hareth Lokhorst, Henk Valentin, Marie-Louise Lisby, Steen Richardson, Paul G. TI A Phase I/II, Dose-Escalation Study of Daratumumab, A CD38 Mab in Patients with Multiple Myeloma - Preliminary Safety Data SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Gimsing, Peter] Rigshosp, Copenhagen Univ Hosp, DK-2100 Copenhagen, Denmark. [Plesner, Torben] Vejle Hosp, Dept Hematol, Vejle, Denmark. [Nahi, Hareth] Karolinska Inst, Stockholm, Sweden. [Lokhorst, Henk] Univ Med Ctr Utrecht, Dept Hematol, Utrecht, Netherlands. [Valentin, Marie-Louise] Genmab AS, Corp Drug Safety, Copenhagen, Denmark. [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 817 EP 817 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102468 ER PT J AU Bruno, R Jonsson, F Zaki, M Jacques, C Swern, AS Richardson, PG Rajkumar, V Claret, L AF Bruno, Rene Jonsson, Fredrik Zaki, Mohamed Jacques, Christian Swern, Arlene S. Richardson, Paul G. Rajkumar, Vincent Claret, Laurent TI Simulation of Clinical Outcome for Pomalidomide Plus Low-Dose Dexamethasone in Patients with Refractory Multiple Myeloma Based on Week 8 M-Protein Response SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Bruno, Rene; Jonsson, Fredrik; Claret, Laurent] Pharsight, Pharsight Consulting Serv, St Louis, MO USA. [Zaki, Mohamed; Jacques, Christian; Swern, Arlene S.] Celgene Corp, Summit, NJ USA. [Richardson, Paul G.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Rajkumar, Vincent] Mayo Clin, Ctr Canc, Rochester, MN USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 821 EP 822 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102476 ER PT J AU Harvey, RD Jacobus, SJ Rajkumar, SV Greipp, PR Lonial, S AF Harvey, R. Donald Jacobus, Susanna Joan Rajkumar, S. Vincent Greipp, Philip R. Lonial, Sagar TI Renal Function Measures Improve on Lenalidomide and Dexamethasone and Compete with Patient Characteristics to Predict Lenalidomide Dose Density and Hematologic Toxicity: An E4A03 Analysis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Harvey, R. Donald; Lonial, Sagar] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA. [Jacobus, Susanna Joan] Dana Farber Canc Inst, Boston, MA 02115 USA. [Rajkumar, S. Vincent] Mayo Clin, Coll Med, Div Hematol, Rochester, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 822 EP 822 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102477 ER PT J AU Stroopinsky, D Rosenblatt, J Mills, H Luptakova, K Glotzbecker, B Vasir, B Joyce, R Levine, J Tzachanis, D Arnason, JE Galinsky, I Stone, RM Kufe, D Reiter, Y Avigan, D AF Stroopinsky, Dina Rosenblatt, Jacalyn Mills, Heidi Luptakova, Katarina Glotzbecker, Brett Vasir, Baldev Joyce, Robin Levine, James Tzachanis, Dimitrios Arnason, Jon E. Galinsky, Ilene Stone, Richard M. Kufe, Donald Reiter, Yoram Avigan, David TI MUC1 Inhibition Reverses the Poor Immunogenicity of Leukemia Stem Cells Rendering Them Susceptible to Immunotherapy SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Stroopinsky, Dina; Rosenblatt, Jacalyn; Mills, Heidi; Luptakova, Katarina; Glotzbecker, Brett; Joyce, Robin; Levine, James; Tzachanis, Dimitrios; Arnason, Jon E.; Avigan, David] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Vasir, Baldev; Galinsky, Ilene; Stone, Richard M.; Kufe, Donald] Dana Farber Canc Inst, Boston, MA 02115 USA. [Reiter, Yoram] Technion Israel Inst Technol, Haifa, Israel. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 822 EP 823 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102478 ER PT J AU Haile, DJ Utz, K Toro, JJ Frye, BL Neumon, B Shuko, L Freytes, CO AF Haile, David J. Utz, Kenneth Toro, Juan J. Frye, Brenda L. Neumon, Bonita Shuko, Lee Freytes, Cesar O. TI Nicotine Use During Mobilization Is Associated with More Efficient Stem Cell Collection SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Utz, Kenneth] Audie L Murphy Mem Vet Adm Med Ctr, S Texas Vet Hlth Care Syst, Dept Pharm, San Antonio, TX 78284 USA. [Frye, Brenda L.] Audie Murphy Vet Affairs BMT, San Antonio, TX USA. [Shuko, Lee] S Texas Vet Hlth Care Syst, Res & Dev Serv, San Antonio, TX USA. [Freytes, Cesar O.] Audie L Murphy Mem Vet Adm Med Ctr, Med Serv BMT 111, San Antonio, TX 78284 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 843 EP 843 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102529 ER PT J AU Palmer, J Lee, SJ Chai, XY Storer, B Pidala, J Cutler, CS Arora, M Flowers, MED Pavletic, SZ Vogelsang, GB Inamoto, Y Jagasia, M George, C Martin, PJ AF Palmer, Jeanne Lee, Stephanie J. Chai, Xiaoyu Storer, Barry Pidala, Joseph Cutler, Corey S. Arora, Mukta Flowers, Mary E. D. Pavletic, Steven Z. Vogelsang, Georgia B. Inamoto, Yoshihiro Jagasia, Madan George, Chen Martin, Paul J. TI Comparison of Proposed NIH Response Criteria with Clinician-Reported Changes in Organ-Specific and Overall Response SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Palmer, Jeanne] MCW & Froedtert Clin Canc Ctr, Milwaukee, WI USA. [Storer, Barry] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA. [Pidala, Joseph] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Cutler, Corey S.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Arora, Mukta] Univ Minnesota, Med Blood & Marrow Transplant Program, Minneapolis, MN USA. [Pavletic, Steven Z.] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Vogelsang, Georgia B.] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. [Jagasia, Madan] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [George, Chen] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 863 EP 863 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102573 ER PT J AU Inamoto, Y Cutler, CS Chai, XY Arora, M Martin, PJ Pidala, J Palmer, J Pavletic, SZ Jagasia, MH Jacobsohn, D Carpenter, PA Flowers, MED Khera, N Vogelsang, GB Weisdorf, DJ Storer, B Lee, SJ AF Inamoto, Yoshihiro Cutler, Corey S. Chai, Xiaoyu Arora, Mukta Martin, Paul J. Pidala, Joseph Palmer, Jeanne Pavletic, Steven Z. Jagasia, Madan H. Jacobsohn, David Carpenter, Paul A. Flowers, Mary E. D. Khera, Nandita Vogelsang, Georgia B. Weisdorf, Daniel J. Storer, Barry Lee, Stephanie J. TI Calculated NIH Response Correlates with Changes in Patient-Reported Symptoms but Not with Quality of Life: Results From the Chronic Gvhd Consortium SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Inamoto, Yoshihiro; Chai, Xiaoyu; Martin, Paul J.; Carpenter, Paul A.; Flowers, Mary E. D.; Khera, Nandita; Storer, Barry; Lee, Stephanie J.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Cutler, Corey S.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Arora, Mukta; Weisdorf, Daniel J.] Univ Minnesota, Minneapolis, MN USA. [Pidala, Joseph] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Palmer, Jeanne] MCW, Milwaukee, WI USA. [Palmer, Jeanne] Froedtert Clin Canc Ctr, Milwaukee, WI USA. [Pavletic, Steven Z.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. [Jagasia, Madan H.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Jacobsohn, David] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Vogelsang, Georgia B.] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 868 EP 868 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102583 ER PT J AU Thompson, LA Guthrie, KA Budde, LE Till, BG Press, OW Chauncey, T Pagel, JM Petersdorf, SH Bensinger, WI Holmberg, L Shustov, AR Green, DJ Maloney, DG Gopal, AK AF Thompson, Leslie A. Guthrie, Katherine A. Budde, Lihua Elizabeth Till, Brian G. Press, Oliver W. Chauncey, Thomas Pagel, John M. Petersdorf, Stephen H. Bensinger, William I. Holmberg, Leona Shustov, Andrei R. Green, Damian J. Maloney, David G. Gopal, Ajay K. TI The Pre-Transplant Mantle Cell Lymphoma International Prognostic Index Predicts Overall and Progression-Free Survival Following High-Dose Therapy and Autologus Stem Cell Transplant for Mantle Cell Lymphoma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Thompson, Leslie A.] Seattle Canc Care Alliance, Gen Oncol & Hematol, Seattle, WA USA. [Budde, Lihua Elizabeth] Fed Hutchinson Canc Res Ctr, Seattle, WA USA. [Press, Oliver W.; Pagel, John M.; Bensinger, William I.; Green, Damian J.; Gopal, Ajay K.] Univ Washington, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98195 USA. [Chauncey, Thomas] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Shustov, Andrei R.] Univ Washington, Med Ctr, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 886 EP 887 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102621 ER PT J AU Morrison, JF Neufeld, EJ Grace, RF AF Morrison, Jacqueline F. Neufeld, Ellis J. Grace, Rachael F. TI Retrospective Review of Erythropoietin Therapy Versus Supportive Care in Newborns with Hereditary Spherocytosis (HS): Difficulties Implementing Trial Results Into Clinical Practice SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Morrison, Jacqueline F.] Washington Univ, St Louis, MO USA. [Neufeld, Ellis J.; Grace, Rachael F.] Childrens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 906 EP 907 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102661 ER PT J AU Abel, GA Friese, CR Neville, BA Hastings, BT Earle, CC Richardson, LC AF Abel, Gregory A. Friese, Christopher R. Neville, Bridget A. Hastings, B. Taylor Earle, Craig C. Richardson, Lisa C. TI The Anemia Workup in Current Clinical Practice: Results From a Survey of Primary Care Physicians SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Abel, Gregory A.; Neville, Bridget A.; Hastings, B. Taylor] Dana Farber Canc Inst, Boston, MA 02115 USA. [Friese, Christopher R.] Univ Michigan, Ann Arbor, MI 48109 USA. [Earle, Craig C.] Inst Clin Evaluat Sci, Toronto, ON, Canada. [Richardson, Lisa C.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Friese, Christopher/D-2097-2013 OI Friese, Christopher/0000-0002-2281-2056 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 914 EP 914 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102679 ER PT J AU Frelinger, AL Jakubowski, JA Brooks, JK Nigam, A Berny-Lang, MA Barnard, MR Heeney, MM Michelson, AD AF Frelinger, Andrew L., III Jakubowski, Joseph A. Brooks, Julie K. Nigam, Anu Berny-Lang, Michelle A. Barnard, Marc R. Heeney, Matthew M. Michelson, Alan D. TI In Vivo Platelet Activation and Its In Vitro Inhibition by Prasugrel's Active Metabolite In Adolescents with Sickle Cell Disease SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Frelinger, Andrew L., III; Brooks, Julie K.; Nigam, Anu; Berny-Lang, Michelle A.; Barnard, Marc R.; Michelson, Alan D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Childrens Hosp Boston,Ctr Platelet Res Studies, Boston, MA 02115 USA. [Jakubowski, Joseph A.] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 938 EP 938 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103009 ER PT J AU Bauer, DE Xu, J Fujiwara, Y Stamatoyannopoulos, JA Orkin, SH AF Bauer, Daniel E. Xu, Jian Fujiwara, Yuko Stamatoyannopoulos, John A. Orkin, Stuart H. TI Functional Evaluation of HbF-Associated Region of BCL11A Locus SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Bauer, Daniel E.; Fujiwara, Yuko] Harvard Univ, Sch Med, Dana Farber Canc Inst, Childrens Hosp Boston, Boston, MA 02115 USA. [Xu, Jian; Orkin, Stuart H.] Howard Hughes Med Inst, Boston, MA 02115 USA. [Stamatoyannopoulos, John A.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 941 EP 941 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103016 ER PT J AU Kuter, DJ Wang, F Dawson, KL Grotzinger, KM Macahilig, CP AF Kuter, David J. Wang, Feng Dawson, Katie L. Grotzinger, Kelly M. Macahilig, Cynthia P. TI Patient Reported Outcomes Comparison of Chronic Immune Thrombocytopenia (ITP) Patients Switched to Promacta and Nplate SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kuter, David J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Wang, Feng; Dawson, Katie L.; Grotzinger, Kelly M.] GlaxoSmith Kline, Collegeville, PA USA. [Macahilig, Cynthia P.] Med Data Analyt, Parsippany, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 966 EP 967 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597103087 ER PT J AU Dusheiko, G Afdhal, NH Giannini, E Chen, PJ Han, KH Kamel, YM Brainsky, A Geib, J Vasey, SY Patwardhan, R Campbell, F Theodore, D AF Dusheiko, Geoffrey Afdhal, Nezam H. Giannini, Edoardo Chen, Pei-Jer Han, Kwang-Hyub Kamel, Yasser Mostafa Brainsky, Andres Geib, James Vasey, Sandra Y. Patwardhan, Rita Campbell, Fiona Theodore, Dickens TI Final Results of Open-Label Treatment with Eltrombopag During ENABLE 1: A Study of Eltrombopag As An Adjunct for Antiviral Treatment of Hepatitis C Virus Associated with Thrombocytopenia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Dusheiko, Geoffrey] UCL, Sch Med, London W1N 8AA, England. [Afdhal, Nezam H.] Beth Isreal Deaconess Med Ctr, Boston, MA USA. [Giannini, Edoardo] Univ Genoa, Dept Internal Med, Gastroenterol Unit, I-16126 Genoa, Italy. [Chen, Pei-Jer] Natl Tawain Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Taipei, Taiwan. [Han, Kwang-Hyub] Severance Hosp, Seoul, South Korea. [Kamel, Yasser Mostafa; Geib, James; Campbell, Fiona] GlaxoSmith Kline, Uxbridge, Middx, England. [Brainsky, Andres; Vasey, Sandra Y.; Patwardhan, Rita] GlaxoSmithKline Inc, Collegeville, PA USA. [Theodore, Dickens] GlaxoSmithKline Inc, Res Triangle Pk, NC USA. RI Giannini, Edoardo/E-1120-2012 OI Giannini, Edoardo/0000-0001-8526-837X NR 0 TC 1 Z9 1 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 972 EP 972 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103099 ER PT J AU Novakovic, VA Miao, HZ Pipe, S Gilbert, GE AF Novakovic, Valerie A. Miao, Hongzhi Pipe, Steven Gilbert, Gary E. TI Conservative Mutations in the Membrane-Binding Motif of Factor V C2 Domain to Residues of Pseudonaja Textilis Venom Factor V Confer Phosphatidylserine-Independent Activity SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Novakovic, Valerie A.] VA Boston Healthcare Syst, Res, Boston, MA USA. [Miao, Hongzhi; Pipe, Steven] Univ Michigan, Ann Arbor, MI 48109 USA. [Gilbert, Gary E.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Med Dept,VA Boston Healthcare Syst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 976 EP 976 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103110 ER PT J AU Berra, L Dzik, WS Coppadoro, A Bloch, KD Yu, BL Spagnolli, E Steinbicker, AU Feelisch, M Fernandez, B Stowell, C Warren, SH Lin, T Zapol, WM AF Berra, Lorenzo Dzik, Walter Sunny Coppadoro, Andrea Bloch, Kenneth D. Yu, Binglan Spagnolli, Ester Steinbicker, Andrea U. Feelisch, Martin Fernandez, Bernadette Stowell, Christopher Warren, Shaw H. Lin, Tian Zapol, Warren M. TI Transfusion of Stored Autologous Blood Alters Reactive Hyperemia and Circulating Nitrite Levels in Healthy Volunteers SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Berra, Lorenzo; Coppadoro, Andrea; Spagnolli, Ester; Stowell, Christopher; Warren, Shaw H.; Lin, Tian] MGH, Boston, MA USA. [Dzik, Walter Sunny] Harvard Univ, Boston, MA 02115 USA. [Bloch, Kenneth D.; Yu, Binglan; Steinbicker, Andrea U.; Zapol, Warren M.] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA. [Feelisch, Martin; Fernandez, Bernadette] Univ Warwick, Sch Med, Coventry CV4 7AL, W Midlands, England. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1008 EP 1008 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103194 ER PT J AU Ko, M Bandukwala, HS An, JG Lamperti, ED Thompson, EC Hastie, R Tsangaratou, A Rajewsky, K Koralov, SB Rao, A AF Ko, Myunggon Bandukwala, Hozefa S. An, Jungeun Lamperti, Edward D. Thompson, Elizabeth C. Hastie, Ryan Tsangaratou, Angeliki Rajewsky, Klaus Koralov, Sergei B. Rao, Anjana TI Tet2 Negatively Regulates Homeostasis and Differentiation of Hematopoietic Stem Cells in Mice SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ko, Myunggon; An, Jungeun; Hastie, Ryan; Tsangaratou, Angeliki; Rao, Anjana] La Jolla Inst Allergy & Immunol, Div Signaling & Gene Express, La Jolla, CA USA. [Bandukwala, Hozefa S.; Lamperti, Edward D.; Thompson, Elizabeth C.; Rajewsky, Klaus] Harvard Univ, Sch Med, Dept Pathol, Immune Dis Inst, Boston, MA 02115 USA. [Bandukwala, Hozefa S.; Lamperti, Edward D.; Thompson, Elizabeth C.; Rajewsky, Klaus] Program Cellular & Mol Med, Boston, MA USA. [Koralov, Sergei B.] NYU, Dept Pathol, Langone Med Ctr, New York, NY 10016 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1017 EP 1017 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103221 ER PT J AU Meyer, SE Rogers, AM Lal, A Lieberman, J Aronow, BJ Komurov, K Grimes, HL AF Meyer, Sara E. Rogers, Andrew M. Lal, Ashish Lieberman, Judy Aronow, Bruce J. Komurov, Kakajan Grimes, H. Leighton TI Unbiased Analyses of Signaling Through Leukemia Associated MicroRNA SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Meyer, Sara E.; Rogers, Andrew M.; Grimes, H. Leighton] Cincinnati Childrens Hosp, Med Ctr, Div Immunobiol, Cincinnati, OH USA. [Lal, Ashish] NCI, Genet Branch, Regulatory RNAs & Canc Sect, Bethesda, MD 20892 USA. [Lieberman, Judy] Harvard Univ, Childrens Hosp, Immune Dis Inst, Program Cellular & Mol Med,Sch Med, Boston, MA 02115 USA. [Aronow, Bruce J.] Cincinnati Childrens Hosp, Med Ctr, Div Biomed Informat, Cincinnati, OH USA. RI Aronow, Bruce/F-8438-2012; OI Meyer, Sara/0000-0003-2930-748X NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1022 EP 1023 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597103239 ER PT J AU Nakamura, M Wu, LZ Kojika, S Griffin, JD Sugita, K AF Nakamura, Makoto Wu, Lizi Kojika, Satoru Griffin, James D. Sugita, Kanji TI Activation of Notch1 Signaling Suppresses Granulocytic Differentiation and Maintains a Part of Myeloid Progenitor Cells At the Immature Stage SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Nakamura, Makoto; Kojika, Satoru; Sugita, Kanji] Univ Yamanashi, Sch Med, Dept Pediat, Tamaho, Yamanashi, Japan. [Wu, Lizi] Univ Florida, Shands Canc Ctr, Gainesville, FL USA. [Griffin, James D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1023 EP 1024 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597103241 ER PT J AU Silberstein, L Osawa, M Lin, C Kharchenko, P Lo Celso, C Aribeana, C Scadden, DT AF Silberstein, Lev Osawa, Masatake Lin, Charles Kharchenko, Peter Lo Celso, Cristina Aribeana, Chiaka Scadden, David T. TI Real-Time RT-PCR Analysis of Individual Osteolineage Cells within the Hematopoietic Stem Cell Niche SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Silberstein, Lev] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA. [Osawa, Masatake] Massachusetts Gen Hosp, Ctr Cutaneous Dis Biol, Charlestown, MA USA. [Lo Celso, Cristina] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England. [Aribeana, Chiaka; Scadden, David T.] Harvard Stem Cell Inst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1028 EP 1029 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597103255 ER PT J AU Li, GQ Arrieta, CN Wang, LD Wagers, AJ Silberstein, LE AF Li, Geqiang Arrieta, Cesar Nombela Wang, Leo D. Wagers, Amy J. Silberstein, Leslie E. TI Age Dependent Alternations In Hematopoietic Stem Cell Niches SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Li, Geqiang; Arrieta, Cesar Nombela] Childrens Hosp, Transfus Med Program, Boston, MA 02115 USA. [Wang, Leo D.] Dana Farber Childrens Hosp Canc Ctr, Boston, MA USA. [Wagers, Amy J.] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA. [Silberstein, Leslie E.] Childrens Hosp, Joint Program Transfus Med, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1030 EP 1031 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597103261 ER PT J AU Cappelli, E Svahn, J Anur, P Corsolini, F Farruggia, P Bagby, GC Dufour, C AF Cappelli, Enrico Svahn, Johanna Anur, Praveen Corsolini, Fabio Farruggia, Piero Bagby, Grover C., Jr. Dufour, Carlo TI Kinase Inhibitors Reduce TNF-Alpha Over-Production in Monocytes From Fanconi Anemia Group A Patients SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Cappelli, Enrico; Svahn, Johanna; Corsolini, Fabio; Dufour, Carlo] Ist Giannina Gaslini, I-16148 Genoa, Italy. [Anur, Praveen] Doernbecher Childrens Hosp, Portland, OR USA. [Anur, Praveen; Bagby, Grover C., Jr.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Farruggia, Piero] G Di Cristina Hosp, Palermo, Italy. [Bagby, Grover C., Jr.] Portland VA Med Ctr, Portland, OR USA. RI Cappelli, Enrico/K-7954-2016 OI Cappelli, Enrico/0000-0001-5910-9260 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1036 EP 1036 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103275 ER PT J AU Liu, Y Zhang, Y Quang, P Ngo, HT Azab, F Azab, AK Morgan, B Maiso, P Reagan, M Rombaoa, CP Sacco, A Roccaro, AM Carrasco, R Ghobrial, IM AF Liu, Yang Zhang, Yong Quang, Phong Ngo, Hai T. Azab, Feda Azab, Abdel Kareem Morgan, Brittany Maiso, Patricia Reagan, Michaela Rombaoa, Christopher P. Sacco, Antonio Roccaro, Aldo M. Carrasco, Ruben Ghobrial, Irene M. TI Deregulation of TNFRSF18 (GITR) Through Promoter CpG Island Methylation Induces Tumor Proliferation in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Liu, Yang; Zhang, Yong; Quang, Phong; Ngo, Hai T.; Azab, Feda; Azab, Abdel Kareem; Morgan, Brittany; Maiso, Patricia; Reagan, Michaela; Rombaoa, Christopher P.; Sacco, Antonio; Roccaro, Aldo M.; Carrasco, Ruben; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Reagan, Michaela/E-3549-2017 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1042 EP 1042 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103290 ER PT J AU Ueno, S Lu, JY Jie, H Li, AL Zhang, XX Silberstein, LE Ritz, J Chai, L AF Ueno, Shikiko Lu, Jiayun Jie, He Li, Ailing Zhang, XiaoXian Silberstein, Leslie E. Ritz, Jerome Chai, Li TI SALL4 Is a Key Survival Factor in Acute B-Cell Lymphoblastic Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ueno, Shikiko; Lu, Jiayun; Jie, He; Li, Ailing; Zhang, XiaoXian; Chai, Li] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Silberstein, Leslie E.] Childrens Hosp, Joint Program Transfus Med, Boston, MA 02115 USA. [Ritz, Jerome] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1043 EP 1043 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103294 ER PT J AU Sweetser, D Ramasamy, S Blackburn, JS Langenau, DM AF Sweetser, David Ramasamy, Selvi Blackburn, Jessica S. Langenau, David M. TI The TLE1 Tumor Suppressor Regulates Myc Induced Leukemogenesis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Sweetser, David] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA. [Blackburn, Jessica S.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Charlestown, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1060 EP 1060 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103339 ER PT J AU Pogosova-Agadjanyan, EL Kopecky, KJ Petersdorf, S Erba, HP Stone, RM Meshinchi, S Nevill, TJ Radich, JP Stenke, L Slovak, ML Stuart, RK Tallman, MS Willman, CL Mortensen, RM Wentz, BL Appelbaum, FR Stirewalt, DL AF Pogosova-Agadjanyan, Era L. Kopecky, Kenneth J. Petersdorf, Stephen Erba, Harry Paul Stone, Richard M. Meshinchi, Soheil Nevill, Thomas J. Radich, Jerald P. Stenke, Leif Slovak, Marilyn L. Stuart, Robert K. Tallman, Martin S. Willman, Cheryl L. Mortensen, Rebecca M. Wentz, Breanna L. Appelbaum, Frederick R. Stirewalt, Derek L. TI Prognostic Significance of FLT3 and NPM1 Mutations in Adults of Age 18-60 with De Novo Acute Myeloid Leukemia (AML) on SWOG S0106 Study: A Study by FHCRC and SWOG SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Pogosova-Agadjanyan, Era L.; Meshinchi, Soheil; Radich, Jerald P.; Mortensen, Rebecca M.; Wentz, Breanna L.; Appelbaum, Frederick R.; Stirewalt, Derek L.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA. [Kopecky, Kenneth J.] Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98104 USA. [Petersdorf, Stephen] Seattle Canc Care Alliance, Seattle, WA USA. [Erba, Harry Paul] Univ Michigan, Div Hematol & Oncol, Ann Arbor, MI 48109 USA. [Stone, Richard M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Nevill, Thomas J.] Univ British Columbia, Div Hematol, Leukemia BMT Program BC, Vancouver, BC V5Z 1M9, Canada. [Stenke, Leif] Karolinska Univ Hosp, Stockholm, Sweden. [Tallman, Martin S.] City Hope Natl Med Ctr, Cytogenet, Duarte, CA USA. [Stuart, Robert K.] Med Univ S Carolina, Charleston, SC 29425 USA. [Tallman, Martin S.] Northwestern Univ, Sch Med, Chicago, IL USA. [Willman, Cheryl L.] Univ New Mexico, Ctr Canc, UNM Canc Res Facil, Albuquerque, NM 87131 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1080 EP 1080 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103386 ER PT J AU Foran, JM Sun, ZX Fernandez, HF Cripe, LD Ketterling, RP Racevskis, J Luger, SM Paietta, E Lazarus, HM Litzow, MR Tallman, MS AF Foran, James M. Sun, Zhuoxin Fernandez, Hugo F. Cripe, Larry D. Ketterling, Rhett P. Racevskis, Janis Luger, Selina M. Paietta, Elisabeth Lazarus, Hillard M. Litzow, Mark. R. Tallman, Martin S. TI The Impact of Obesity on the Presentation & Outcome of Adult Acute Myeloid Leukemia (AML) - ECOG Studies E1900 & E3999 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Foran, James M.] Mayo Clin Florida, Div Hematol Oncol, Jacksonville, FL USA. [Sun, Zhuoxin] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Fernandez, Hugo F.] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Cripe, Larry D.] Indiana Univ, Ctr Canc, Indianapolis, IN 46204 USA. [Ketterling, Rhett P.] Mayo Clin, Dept Lab Med, Div Cytogenet, Rochester, MN USA. [Racevskis, Janis] Montefiore Med Ctr, North Div, Bronx, NY 10467 USA. [Luger, Selina M.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Lazarus, Hillard M.] Univ Hosp Case Med Ctr, Cleveland, OH USA. [Tallman, Martin S.] Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY 10021 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1101 EP 1102 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597103434 ER PT J AU Etchin, J Kentsis, A Sanda, T Kung, AL Stone, RM McCauley, D Kauffman, M Shacham, S Look, T AF Etchin, Julia Kentsis, Alex Sanda, Takaomi Kung, Andrew L. Stone, Richard M. McCauley, Dilara Kauffman, Michael Shacham, Sharon Look, Thomas TI KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Etchin, Julia; Kentsis, Alex; Sanda, Takaomi; Look, Thomas] Harvard Univ, Sch Med, Dana Farber Canc Inst, Childrens Hosp Boston, Boston, MA 02115 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Kung, Andrew L.] Childrens Hosp, Boston, MA 02115 USA. [McCauley, Dilara; Kauffman, Michael] Karyopharm Therapeut, Boston, MA USA. [Shacham, Sharon] Karyopharm, Boston, MA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1126 EP 1126 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597103488 ER PT J AU Brown, JR Davids, MS Rodon, J Abrisqueta, P DeCillis, AP Rockich, K Egile, C Kelly, A Xu, Y Lager, J Awan, FT AF Brown, Jennifer R. Davids, Matthew S. Rodon, Jordi Abrisqueta, Pau DeCillis, Arthur P. Rockich, Kevin Egile, Coumaran Kelly, Adrianne Xu, Yi Lager, Joanne Awan, Farrukh T. TI Phase I Trial of SAR245408 (S08), a Pan-Phosphatidylinositol 3 Kinase (PI3K) Inhibitor, in Patients with Chronic Lymphocytic Leukemia (CLL) and Lymphoma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Davids, Matthew S.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Rodon, Jordi] Hosp Univ Vall dHebron, Serv Oncol, Barcelona, Spain. [Abrisqueta, Pau] Hosp Univ Vall dHebron, Dept Hematol, Barcelona, Spain. [DeCillis, Arthur P.] Exelixis Inc, Guilford, CT USA. [Rockich, Kevin; Kelly, Adrianne; Xu, Yi; Lager, Joanne] Sanofi, Cambridge, MA USA. [Egile, Coumaran] Ctr Rech, Sanofi, France. [Awan, Farrukh T.] Georgia Hlth Sci Univ, Augusta, GA USA. RI Awan, Farrukh/L-5642-2016 OI Awan, Farrukh/0000-0003-1813-9812 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1153 EP 1153 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104034 ER PT J AU Ghobrial, IM Boswell, EN Banwait, R Poon, T Donovan, A Chuma, S Kunsman, J Warren, D Bagshaw, M Anderson, KC Richardson, PG Treon, S AF Ghobrial, Irene M. Boswell, Erica N. Banwait, Ranjit Poon, Tiffany Donovan, Amanda Chuma, Stacey Kunsman, Janet Warren, Diane Bagshaw, Meghan Anderson, Kenneth C. Richardson, Paul G. Treon, Steven TI Phase I Trial of Everolimus and Rituximab or Everolimus, Bortezomib and Rituximab in Relapsed or Relapsed/Refractory Waldenstrom's Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ghobrial, Irene M.; Banwait, Ranjit; Poon, Tiffany; Donovan, Amanda; Chuma, Stacey; Kunsman, Janet; Warren, Diane; Bagshaw, Meghan; Anderson, Kenneth C.; Treon, Steven] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1163 EP 1164 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104056 ER PT J AU Ghobrial, IM Banwait, R Poon, T Campigotto, F Boswell, EN Chuma, S Kunsman, J Donovan, A Bagshaw, M Warren, D Anderson, KC Richardson, PG Weller, E Murphy, TJ Matous, J AF Ghobrial, Irene M. Banwait, Ranjit Poon, Tiffany Campigotto, Federico Boswell, Erica N. Chuma, Stacey Kunsman, Janet Donovan, Amanda Bagshaw, Meghan Warren, Diane Anderson, Kenneth C. Richardson, Paul G. Weller, Edie Murphy, Timothy J. Matous, Jeffrey TI Final Results of the Phase II Trial of Single Agent Panobinostat (LBH589) in Relapsed or Relapsed/Refractory Waldenstrom Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Weller, Edie] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Biostat & Computat, Boston, MA 02115 USA. [Campigotto, Federico] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Murphy, Timothy J.] Rocky Mt Canc Ctr, Colorado Springs, CO USA. [Matous, Jeffrey] Rocky Mt Canc Ctr, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1164 EP 1164 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104057 ER PT J AU Banwait, R Weller, E Ropur, N Paba-Prada, CE Benajiba, L Bagshaw, M Treon, SP Ghobrial, IM AF Banwait, Ranjit Weller, Edie Ropur, Nitin Paba-Prada, Claudia E. Benajiba, Lina Bagshaw, Meghan Treon, Steven P. Ghobrial, Irene M. TI The Role of Bortezomib-Containing Regimens in Improving Response in Patients with Waldenstrom Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Weller, Edie] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Biostat & Computat, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1167 EP 1168 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104064 ER PT J AU Zhang, Y Rombaoa, CP Roccaro, AM Obad, S Broom, O Fernandes, SM Banwait, R Liu, Y Ngo, HT Quang, P Morgan, B Azab, AK Azab, F Maiso, P Reagan, M Sacco, A Boswell, EN Kauppinen, S Brown, JR Ghobrial, IM AF Zhang, Yong Rombaoa, Christopher P. Roccaro, Aldo M. Obad, Susanna Broom, Oliver Fernandes, Stacey M. Banwait, Ranjit Liu, Yang Ngo, Hai T. Quang, Phong Morgan, Brittany Azab, Abdel Kareem Azab, Feda Maiso, Patricia Reagan, Michaela Sacco, Antonio Boswell, Erica N. Kauppinen, Sakari Brown, Jennifer R. Ghobrial, Irene M. TI LNA Anti-MicroRNA-155: A Novel Therapeutic Strategy in Waldenstrom Macroglobulinemia and Chronic Lymphocytic Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Zhang, Yong; Roccaro, Aldo M.; Liu, Yang; Ngo, Hai T.; Morgan, Brittany; Azab, Abdel Kareem; Azab, Feda; Reagan, Michaela; Sacco, Antonio] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Obad, Susanna; Broom, Oliver; Kauppinen, Sakari] Santaris Pharma, Horsholm, Denmark. [Fernandes, Stacey M.; Brown, Jennifer R.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. RI Reagan, Michaela/E-3549-2017 NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1173 EP 1174 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104079 ER PT J AU Nieborowska-Skorska, M Kopinski, P Ray, R Hoser, G Ngaba, D Flis, S Cramer, K Reddy, MM Koptyra, M Penserga, T Glodkowska-Mrowka, E Ambrozek, M Seferynska, I Niesiobedzka-Krezel, J Bolton, E Slupianek, A Holyoake, TL Eaves, CJ Cerny-Reiterer, S Valent, P Hochhaus, A Hughes, TP van der Kuip, H Sattler, M Wiktor-Jedrzejczak, W Richardson, C Dorrance, AM Stoklosa, T Williams, DA Skorski, T AF Nieborowska-Skorska, Margaret Kopinski, Piotr Ray, Regina Hoser, Grazyna Ngaba, Danielle Flis, Sylwia Cramer, Kimberly Reddy, Mamatha M. Koptyra, Mateusz Penserga, Tyrone Glodkowska-Mrowka, Eliza Ambrozek, Magdalena Seferynska, Ilona Niesiobedzka-Krezel, Joanna Bolton, Elisabeth Slupianek, Artur Holyoake, Tessa L. Eaves, Connie J. Cerny-Reiterer, Sabine Valent, Peter Hochhaus, Andreas Hughes, Timothy P. van der Kuip, Heiko Sattler, Martin Wiktor-Jedrzejczak, Wieslaw Richardson, Christine Dorrance, Adrienne M. Stoklosa, Tomasz Williams, David A. Skorski, Tomasz TI Targeting Rac2-Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Nieborowska-Skorska, Margaret; Kopinski, Piotr; Ray, Regina; Ngaba, Danielle; Flis, Sylwia; Cramer, Kimberly; Koptyra, Mateusz; Penserga, Tyrone; Bolton, Elisabeth; Slupianek, Artur; Skorski, Tomasz] Temple Univ, Dept Microbiol & Immunol, Sch Med, Philadelphia, PA 19122 USA. [Hoser, Grazyna; Ambrozek, Magdalena] Med Ctr Postgrad Educ, Dept Clin Cytol, Warsaw, Poland. [Glodkowska-Mrowka, Eliza; Stoklosa, Tomasz] Med Univ Warsaw, Dept Immunol, Warsaw, Poland. [Reddy, Mamatha M.; Sattler, Martin] Dana Farber Canc Inst, Boston, MA 02115 USA. [Seferynska, Ilona] Inst Hematol & Blood Transfus, Warsaw, Poland. [Niesiobedzka-Krezel, Joanna; Wiktor-Jedrzejczak, Wieslaw] Med Univ Warsaw, Dept Hematol Oncol & Internal Dis, Warsaw, Poland. [Holyoake, Tessa L.] Univ Glasgow, Paul OGorman Leukemia Res Ctr, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland. [Eaves, Connie J.] BC Canc Agcy, Terry Fox Lab, Vancouver, BC, Canada. [Cerny-Reiterer, Sabine; Valent, Peter] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria. [Hochhaus, Andreas] Univ Klinikum Jena, Jena, Germany. [Hughes, Timothy P.] Royal Adelaide Hosp, Dept Haematol, SA Pathol, Adelaide, SA 5000, Australia. [van der Kuip, Heiko] Univ Tubingen, Stuttgart, Germany. [van der Kuip, Heiko] Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany. [Richardson, Christine] Univ NC Charlotte, Dept Biol, Charlotte, NC USA. [Richardson, Christine] Univ NC Charlotte, Ctr Bioinformat, Charlotte, NC USA. [Dorrance, Adrienne M.; Williams, David A.] Childrens Hosp, Div Hematol & Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 1 U2 7 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1176 EP 1177 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104087 ER PT J AU Harb, JG Neviani, P Huettner, CS Marcucci, G Perrotti, D AF Harb, Jason G. Neviani, Paolo Huettner, Claudia S. Marcucci, Guido Perrotti, Danilo TI Combined Pharmacologic Inhibition of Bcl-Xl/Bcl-2 and mTORC1/2 Survival Signals Trigger Apoptosis in BCR-ABL1(+) in Vitro Models of Blast Crisis Chronic Myelogenous Leukemia (CML-BC), and Primary CD34(+)/CD38(-) Stem and CD34(+) progenitor Cells From CML-BC Patients SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Harb, Jason G.; Neviani, Paolo; Perrotti, Danilo] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Huettner, Claudia S.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Marcucci, Guido] Ohio State Univ, Div Hematol, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1177 EP 1178 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104089 ER PT J AU Weisberg, EL Manley, PW Kung, AL Griffin, JD AF Weisberg, Ellen L. Manley, Paul W. Kung, Andrew L. Griffin, James D. TI Potentiation of the Effects of Nilotinib by Combination with Plerixafor in a Mouse Model of BCR-ABL-Positive Residual Disease SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Weisberg, Ellen L.; Griffin, James D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Manley, Paul W.] Novartis Inst Biomed Res, Basel, Switzerland. [Kung, Andrew L.] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Kung, Andrew L.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Kung, Andrew L.] Childrens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1177 EP 1177 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104088 ER PT J AU Guerin, A Bollu, VK Guo, A Stepner, M Griffin, JD Wu, EQ AF Guerin, Annie Bollu, Vamsi K. Guo, Amy Stepner, Michael Griffin, James D. Wu, Eric Qiong TI Comparison of Adherence Between Nilotinib and Dasatinib As Second-Line Therapies in Chronic Myeloid Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Guerin, Annie; Stepner, Michael; Wu, Eric Qiong] Anal Grp Inc, Consulting, Boston, MA USA. [Bollu, Vamsi K.] US Cd&Ma, E Hanover, NJ USA. [Guo, Amy] Novartis Pharmaceut, Hlth Econ & Outcomes Res, E Hanover, NJ USA. [Griffin, James D.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1184 EP 1184 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104105 ER PT J AU Ailawadhi, S Miller, CB Jillella, AP Koshy, N Tudor, B Akard, LP Ericson, SG Lin, FP Radich, JP DeAngelo, DJ AF Ailawadhi, Sikander Miller, Carole B. Jillella, Anand P. Koshy, Nebu Tudor, Brian Akard, Luke P. Ericson, Solveig G. Lin, Felice P. Radich, Jerald P. DeAngelo, Daniel J. TI Effect of Nilotinib (NIL) on Molecular Response in Chronic Myelogenous Leukemia - Chronic Phase (CML-CP) Patients (pts) with a Suboptimal Molecular Response to Imatinib (IM)-ENABL Study Update SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Ailawadhi, Sikander] USC Norris Comprehens Canc Ctr, Los Angeles, CA USA. [Miller, Carole B.] St Agnes Hosp, Baltimore, MD USA. [Jillella, Anand P.] Georgia Hlth Sci Univ, Augusta, GA USA. [Koshy, Nebu] Louisiana State Univ, Hlth Sci Ctr, Dept Med, Feist Weiller Canc Ctr, Shreveport, LA 71105 USA. [Tudor, Brian] Cent Utah Clin, Provo, UT USA. [Akard, Luke P.] Indiana Blood & Marrow Transplantat, Beech Grove, IN USA. [Ericson, Solveig G.; Lin, Felice P.] Novartis Pharmaceut, E Hanover, NJ USA. [Radich, Jerald P.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [DeAngelo, Daniel J.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1193 EP 1193 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104122 ER PT J AU Raza, A Galili, N Mulford, D Smith, SE Brown, G Meng, L Steensma, DP Lyons, RM Boccia, R Sekeres, MA Garcia-Manero, G Mesa, RA AF Raza, Azra Galili, Naomi Mulford, Deborah Smith, Scott E. Brown, Gail Meng, Lisa Steensma, David P. Lyons, Roger M. Boccia, Ralph Sekeres, Mikkael A. Garcia-Manero, Guillermo Mesa, Ruben A. TI Phase 1 Dose-Ranging Study of Oral Ezatiostat Hydrochloride (Telintra (R), TLK199) in Combination with Lenalidomide (Revlimid (R)) in Patients with Non-Deletion(5q) Low to Intermediate-1 Risk Myelodysplastic Syndrome (MDS) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Raza, Azra] Columbia Presbyterian Med Ctr, New York, NY 10032 USA. [Galili, Naomi] Columbia Univ, Med Ctr, New York, NY USA. [Mulford, Deborah] Univ Rochester, Rochester, NY USA. [Smith, Scott E.] Loyola Univ, Chicago Med Ctr, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA. [Brown, Gail; Meng, Lisa] Telik Inc, Palo Alto, CA USA. [Steensma, David P.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lyons, Roger M.] Canc Care Ctr S Texas, San Antonio, TX USA. [Boccia, Ralph] Ctr Canc & Blood Disorders, Bethesda, MD USA. [Sekeres, Mikkael A.] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44106 USA. [Garcia-Manero, Guillermo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Mesa, Ruben A.] Mayo Clin, Scottsdale, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1197 EP 1198 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104129 ER PT J AU Rassenti, LZ Ghia, EM Werner, L Neuberg, D Fabbri, M Volinia, S Widhopf, GF Croce, CM Kipps, TJ AF Rassenti, Laura Z. Ghia, Emanuela M. Werner, Lillian Neuberg, Donna Fabbri, Muller Volinia, Stefano Widhopf, George F., II Croce, Carlo M. Kipps, Thomas J. TI MicroRNA Profiling in Patients with CLL B Cells Expressing the Unmutated IGHV1-69 Gene SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Rassenti, Laura Z.; Ghia, Emanuela M.; Widhopf, George F., II; Kipps, Thomas J.] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 92093 USA. [Werner, Lillian; Neuberg, Donna] Dana Farber Canc Inst, Boston, MA 02115 USA. [Croce, Carlo M.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. RI Volinia, Stefano/A-3029-2010 OI Volinia, Stefano/0000-0003-0910-3893 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1228 EP 1228 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104197 ER PT J AU Brown, JR Tesar, B Werner, L Mikler, E Reynolds, H Thompson, C Fisher, DC Takebe, N Neuberg, D Freedman, AS AF Brown, Jennifer R. Tesar, Bethany Werner, Lillian Mikler, Evgeny Reynolds, Hazel Thompson, Christina Fisher, David C. Takebe, Naoko Neuberg, Donna Freedman, Arnold S. TI Obatoclax in Combination with Fludarabine and Rituximab (FR) Is Well-Tolerated and Shows Promising Clinical Activity in Relapsed CLL/SLL SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Brown, Jennifer R.; Fisher, David C.; Freedman, Arnold S.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA. [Mikler, Evgeny; Reynolds, Hazel; Thompson, Christina] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Takebe, Naoko] NCI, Canc Therapy Evaluat Program NCI CTEP, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1236 EP 1236 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104216 ER PT J AU Hari, P Pasquini, MC Logan, BR Stadtmauer, EA Krishnan, A Howard, A Alvi, S Harding, S Carter, SL Rajkumar, V Alyea, EP Qazilbash, M Laport, GG Maloney, DG Giralt, S Vesole, DH AF Hari, Parameswaran Pasquini, Marcelo C. Logan, Brent R. Stadtmauer, Edward A. Krishnan, Amrita Howard, Alan Alvi, Sairah Harding, Stephen Carter, Shelly L. Rajkumar, Vincent Alyea, Edwin P., III Qazilbash, Muzaffar Laport, Ginna G. Maloney, David G. Giralt, Sergio Vesole, David H. TI Immunoglobulin Free Light Chain (FLC) and Heavy Chain/Light Chain (HLC) Assays - Comparison with Electrophoretic Responses in Multiple Myeloma (MM) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Hari, Parameswaran; Pasquini, Marcelo C.; Logan, Brent R.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Stadtmauer, Edward A.] Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Krishnan, Amrita] City Hope Natl Med Ctr, Duarte, CA 91010 USA. [Howard, Alan] Natl Marrow Donor Program, Minneapolis, MN USA. [Alvi, Sairah] Binding Site Inc, Oak Brook, IL USA. [Harding, Stephen] Binding Site Grp Ltd, Birmingham, W Midlands, England. [Carter, Shelly L.] EMMES Corp, Rockville, MD USA. [Rajkumar, Vincent] Mayo Clin, Rochester, MN USA. [Alyea, Edwin P., III] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Qazilbash, Muzaffar] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA. [Laport, Ginna G.] Stanford Univ, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA. [Maloney, David G.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Giralt, Sergio] Mem Sloan Kettering Canc Ctr, Adult BMT Serv, New York, NY 10021 USA. [Vesole, David H.] Hackensack Univ, Med Ctr, John Theurer Canc Ctr, Hackensack, NJ USA. NR 0 TC 1 Z9 2 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1241 EP 1242 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104228 ER PT J AU Eda, H Santo, L Cirstea, DD Pozzi, S Canavese, M Scullen, TA Vallet, S Evans, E Singh, J Raje, NS AF Eda, Homare Santo, Loredana Cirstea, Diana D. Pozzi, Samantha Canavese, Miriam Scullen, Tyler A. Vallet, Sonia Evans, Erica Singh, Juswinder Raje, Noopur S. TI Targeting Bruton's Tyrosine Kinase As a Novel Approach to Inhibit Osteoclast Function in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Eda, Homare; Santo, Loredana; Pozzi, Samantha; Canavese, Miriam; Scullen, Tyler A.; Vallet, Sonia; Raje, Noopur S.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc, Boston, MA USA. [Cirstea, Diana D.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. [Evans, Erica; Singh, Juswinder] Avila Therapeut Inc, Bedford, MA USA. RI Pozzi, Samantha/A-7617-2012 OI Pozzi, Samantha/0000-0001-7917-1774 NR 0 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1243 EP 1244 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104233 ER PT J AU Shah, PK Samur, MK Li, C Munshi, NC AF Shah, Parantu K. Samur, Mehmet Kemal Li, Cheng Munshi, Nikhil C. TI Studying Evolution of Multiple Myeloma with CanEvolve SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Shah, Parantu K.; Samur, Mehmet Kemal; Li, Cheng] Dana Farber Canc Inst, Boston, MA 02115 USA. [Munshi, Nikhil C.] VA Boston Healthcare Syst, Hematol, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1245 EP 1245 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104237 ER PT J AU Lohr, J Stojanov, P Lawrence, MS Auclair, D Carter, S Sougnez, C Gould, J Cruz-Gordillo, P Chapman, MA Getz, G Golub, TR AF Lohr, Jens Stojanov, Petar Lawrence, Michael S. Auclair, Daniel Carter, Scott Sougnez, Canie Gould, Joshua Cruz-Gordillo, Peter Chapman, Michael A. Getz, Gad Golub, Todd R. TI Multiple Myeloma Sequencing Reveals Subclonality and Timing of Genetic Alterations SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lohr, Jens] DFCI, Boston, MA USA. [Stojanov, Petar; Lawrence, Michael S.; Auclair, Daniel; Carter, Scott; Sougnez, Canie; Gould, Joshua; Cruz-Gordillo, Peter; Chapman, Michael A.; Getz, Gad] Broad Inst, Cambridge, MA USA. [Golub, Todd R.] Broad Inst Harvard Univ & Massachusetts Inst Tech, Canc Program, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1250 EP 1250 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104248 ER PT J AU Fabre, C Mimura, N Bobb, K Gorgun, G Cirstea, DD Hu, YG Minami, J Ohguchi, H Zhang, J Meshulam, J Mitsiades, CS Richardson, PG Hideshima, T Anderson, KC AF Fabre, Claire Mimura, Naoya Bobb, Kathryn Gorgun, Gullu Cirstea, Diana D. Hu, Yiguo Minami, Jiro Ohguchi, Hiroto Zhang, Jie Meshulam, Jeffrey Mitsiades, Constantine S. Richardson, Paul G. Hideshima, Teru Anderson, Kenneth C. TI Dual Inhibition of Canonical and Non-Canonical NF-KB Pathway Demonstrates Significant Anti-Tumor Activities in Multiple Myeloma (MM) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Fabre, Claire; Mimura, Naoya; Gorgun, Gullu; Cirstea, Diana D.; Hu, Yiguo; Minami, Jiro; Ohguchi, Hiroto; Mitsiades, Constantine S.; Richardson, Paul G.; Hideshima, Teru] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. [Bobb, Kathryn; Meshulam, Jeffrey] Profectus BioSci Inc, Baltimore, MD USA. [Zhang, Jie] Rel MD Inc, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1252 EP 1252 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104253 ER PT J AU Santo, L Hideshima, T Kung, AL Tseng, JC Tamang, D Yang, M Jarpe, M van Duzer, JH Mazitschek, R Cirstea, D Eda, H Scullen, TA Rodig, S Canavese, M Bradner, J Anderson, KC Jones, S Raje, NS AF Santo, Loredana Hideshima, Teru Kung, Andrew L. Tseng, Jen-Chieh Tamang, David Yang, Min Jarpe, Matthew van Duzer, John H. Mazitschek, Ralph Cirstea, Diana Eda, Homare Scullen, Tyler A. Rodig, Scott Canavese, Miriam Bradner, James Anderson, Kenneth C. Jones, Simon Raje, Noopur S. TI Selective HDAC6 Inhibition Via ACY-1215, Either Alone or in Combination with Bortezomib, Restores Osteoblast Function and Suppresses Osteoclast Differentiation in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Santo, Loredana; Eda, Homare; Scullen, Tyler A.; Canavese, Miriam; Raje, Noopur S.] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Boston, MA 02114 USA. [Hideshima, Teru; Cirstea, Diana; Bradner, James; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. [Kung, Andrew L.; Tseng, Jen-Chieh] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Kung, Andrew L.; Tseng, Jen-Chieh] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Kung, Andrew L.; Tseng, Jen-Chieh] Childrens Hosp Boston, Boston, MA USA. [Tamang, David; Yang, Min; Jarpe, Matthew; van Duzer, John H.; Jones, Simon] Acetylon Pharmaceut Inc, Boston, MA USA. [Mazitschek, Ralph] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA. [Rodig, Scott] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA. RI Mazitschek, Ralph/E-3741-2013 OI Mazitschek, Ralph/0000-0002-1105-689X NR 0 TC 0 Z9 0 U1 0 U2 8 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1254 EP 1254 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104259 ER PT J AU Di Martino, MT Leone, E Amodio, N Foresta, U Lionetti, M Pitari, MR Cantafio, MEG Gulla, A Morelli, E Leotta, M Tomaino, V Rossi, M Negrini, M Ferrarini, M Neri, A Anderson, KC Munshi, NC Tagliaferri, P Tassone, P AF Di Martino, Maria Teresa Leone, Emanuela Amodio, Nicola Foresta, Umberto Lionetti, Marta Pitari, Maria Rita Cantafio, Maria Eugenia Gallo Gulla, Annamaria Morelli, Eugenio Leotta, Marzia Tomaino, Vera Rossi, Marco Negrini, Massimo Ferrarini, Manlio Neri, Antonino Anderson, Kenneth C. Munshi, Nikhil C. Tagliaferri, Pierosandro Tassone, Pierfrancesco TI MiR-34a Replacement As a Novel Therapeutic Approach for Multiple Myeloma: Preclinical In Vitro and In Vivo Evidence SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Di Martino, Maria Teresa; Leone, Emanuela; Amodio, Nicola; Foresta, Umberto; Pitari, Maria Rita; Cantafio, Maria Eugenia Gallo; Gulla, Annamaria; Morelli, Eugenio; Leotta, Marzia; Tomaino, Vera; Rossi, Marco; Tagliaferri, Pierosandro] Magna Graecia Univ Catanzaro, Catanzaro, Italy. [Di Martino, Maria Teresa; Leone, Emanuela; Amodio, Nicola; Foresta, Umberto; Pitari, Maria Rita; Cantafio, Maria Eugenia Gallo; Gulla, Annamaria; Morelli, Eugenio; Leotta, Marzia; Tomaino, Vera; Rossi, Marco; Tagliaferri, Pierosandro] T Campanella Canc Ctr, Catanzaro, Italy. [Lionetti, Marta; Neri, Antonino] Univ Milan, Dept Med Sci, IRCCS Policlin Fdn, Milan, Italy. [Negrini, Massimo] Univ Ferrara, Dept Expt & Diagnost Med, Interdept Ctr Canc Res, I-44100 Ferrara, Italy. [Ferrarini, Manlio] IST, Med Oncol Dept C, Natl Inst Canc Res, Genoa, Italy. [Anderson, Kenneth C.; Munshi, Nikhil C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Tassone, Pierfrancesco] Temple Univ, Coll Sci & Technol, Philadelphia, PA 19122 USA. RI Negrini, Massimo/J-2377-2016 OI Negrini, Massimo/0000-0002-0007-1920 NR 0 TC 0 Z9 0 U1 1 U2 6 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1255 EP 1255 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104261 ER PT J AU Kong, SY Landesman, Y Jakubikova, J Sellitto, MA Cagnetta, A Cea, M Chen, MC Cottini, F McMillin, DW Acharya, C Senapedis, W Shacham, S Kauffman, M McCauley, D Saint-Martin, JR Munshi, NC Richardson, PG Anderson, KC Tai, YT AF Kong, Sun-Young Landesman, Yosef Jakubikova, Jana Sellitto, Michael A. Cagnetta, Antonia Cea, Michele Chen, Michelle C. Cottini, Francesca McMillin, Douglas W. Acharya, Chirag Senapedis, William Shacham, Sharon Kauffman, Michael McCauley, Dilara Saint-Martin, Jean-Richard Munshi, Nikhil C. Richardson, Paul G. Anderson, Kenneth C. Tai, Yu-Tzu TI Blockade of Nuclear Export Protein CRM1 (chromosomal region maintenance 1, XPO1) by a Novel, Potent and Selective CRM1 Inhibitor KPT-185 Induces Significant Antitumor Activity Against Human Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kong, Sun-Young; Cagnetta, Antonia; Cea, Michele; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Kong, Sun-Young; Cagnetta, Antonia; Cea, Michele; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myelonth Res, Boston, MA 02115 USA. [Landesman, Yosef] Karyopharm Therapeut Inc, Natick, MA USA. [Jakubikova, Jana] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Dis Ctr, Boston, MA 02115 USA. [Shacham, Sharon; Kauffman, Michael; McCauley, Dilara] Karyopharm Therapeut, Newton, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1256 EP 1257 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104264 ER PT J AU Santo, L Hideshima, T Kung, AL Tseng, JC Tamang, D Yang, M Jarpe, M van Duzer, JH Mazitschek, R Ogier, WC Cirstea, DD Rodig, S Eda, H Scullen, TA Canavese, M Bradner, JE Anderson, KC Jones, S Raje, NS AF Santo, Loredana Hideshima, Teru Kung, Andrew L. Tseng, Jen-Chieh Tamang, David Yang, Min Jarpe, Matthew van Duzer, John H. Mazitschek, Ralph Ogier, Walter C. Cirstea, Diana D. Rodig, Scott Eda, Homare Scullen, Tyler A. Canavese, Miriam Bradner, James E. Anderson, Kenneth C. Jones, Simon Raje, Noopur S. TI Pharmacodynamic and Pharmacokinetic Properties of a Novel and Selective HDAC6 Inhibitor, ACY-1215, in Combination with Bortezomib in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Santo, Loredana; Eda, Homare; Scullen, Tyler A.; Canavese, Miriam; Raje, Noopur S.] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Boston, MA 02114 USA. [Hideshima, Teru; Cirstea, Diana D.; Bradner, James E.; Anderson, Kenneth C.] Harvard Univ, Jerome Lipper Multiple Myeloma Ctr, Dept Med Oncol, Dana Farber Canc Inst,Med Sch, Boston, MA 02114 USA. [Tseng, Jen-Chieh] Dana Farber Canc Inst, Lurie Family Imaging Ctr, Boston, MA 02115 USA. [Tseng, Jen-Chieh] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Tseng, Jen-Chieh] Childrens Hosp Boston, Boston, MA USA. [Tamang, David; Yang, Min; Jarpe, Matthew; van Duzer, John H.; Ogier, Walter C.; Jones, Simon] Acetylon Pharmaceut Inc, Boston, MA USA. [Mazitschek, Ralph] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA. [Rodig, Scott] Harvard Univ, Brigham & Womens Hosp, Dept Pathol, Sch Med, Boston, MA 02115 USA. RI Mazitschek, Ralph/E-3741-2013 OI Mazitschek, Ralph/0000-0002-1105-689X NR 0 TC 0 Z9 0 U1 0 U2 5 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1256 EP 1256 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104263 ER PT J AU Cirstea, D Hideshima, T Santo, L Eda, H Canavese, M Scullen, TA Mahindra, AK Gorgun, G Hu, YG Mimura, N Fabre, C Minami, J Ohguchi, H Anderson, KC Guichard, SM Raje, NS AF Cirstea, Diana Hideshima, Teru Santo, Loredana Eda, Homare Canavese, Miriam Scullen, Tyler A. Mahindra, Anuj K. Gorgun, Gullu Hu, Yiguo Mimura, Naoya Fabre, Claire Minami, Jiro Ohguchi, Hiroto Anderson, Kenneth C. Guichard, Sylvie M. Raje, Noopur S. TI DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Cirstea, Diana; Santo, Loredana; Eda, Homare; Canavese, Miriam; Scullen, Tyler A.; Mahindra, Anuj K.] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Boston, MA 02114 USA. [Hideshima, Teru; Gorgun, Gullu; Hu, Yiguo; Mimura, Naoya; Fabre, Claire; Minami, Jiro; Ohguchi, Hiroto; Anderson, Kenneth C.; Raje, Noopur S.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA. [Guichard, Sylvie M.] AstraZeneca, Macclesfield, Cheshire, England. NR 0 TC 0 Z9 0 U1 0 U2 6 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1257 EP 1258 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104267 ER PT J AU Cea, M Cagnetta, A Tai, YT Fulciniti, M Hideshima, T Chauhan, D Kong, SY Calimeri, T Cottini, F Jakubikova, J Nencioni, A Gobbi, M Patrone, F Anderson, KC AF Cea, Michele Cagnetta, Antonia Tai, Yu-Tzu Fulciniti, Mariateresa Hideshima, Teru Chauhan, Dharminder Kong, Sun-Young Calimeri, Teresa Cottini, Francesca Jakubikova, Jana Nencioni, Alessio Gobbi, Marco Patrone, Franco Anderson, Kenneth C. TI Targeting NAD(+) Salvage Pathway Induces Autophagy in Multiple Myeloma Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Cea, Michele; Nencioni, Alessio; Gobbi, Marco; Patrone, Franco] Univ Genoa, Genoa, Italy. [Cagnetta, Antonia; Tai, Yu-Tzu; Fulciniti, Mariateresa; Chauhan, Dharminder; Kong, Sun-Young; Calimeri, Teresa; Cottini, Francesca; Jakubikova, Jana; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA. [Cagnetta, Antonia; Tai, Yu-Tzu; Fulciniti, Mariateresa; Chauhan, Dharminder; Kong, Sun-Young; Calimeri, Teresa; Cottini, Francesca; Jakubikova, Jana; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA. [Hideshima, Teru] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1259 EP 1259 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104271 ER PT J AU Lawasut, P Jacobs, HM Delmore, JE Negri, J McMillin, DW Weisberg, EL Griffin, JD Richardson, PG Anderson, KC Mitsiades, CS AF Lawasut, Panisinee Jacobs, Hannah M. Delmore, Jake E. Negri, Joseph McMillin, Douglas W. Weisberg, Ellen L. Griffin, James D. Richardson, Paul G. Anderson, Kenneth C. Mitsiades, Constantine S. TI In Vitro Anti-Myeloma Activity of the Multitargeted Kinase Inhibitor Midostaurin in the Context of Heterotypic Cocultures of Myeloma Cells with Nonmalignant Microenvironmental Accessory Cells SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lawasut, Panisinee] Chulalongkorn Univ, Dept Med, Div Hematol, Bangkok, Thailand. [Lawasut, Panisinee] King Chulalongkorn Mem Hosp, Bangkok, Thailand. [Jacobs, Hannah M.; Delmore, Jake E.; Negri, Joseph; McMillin, Douglas W.; Weisberg, Ellen L.; Griffin, James D.; Richardson, Paul G.; Anderson, Kenneth C.; Mitsiades, Constantine S.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1260 EP 1260 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104274 ER PT J AU San Miguel, JF Richardson, PG Orlowski, RZ Goldschmidt, H Corzo, D Satler, C Esseltine, DL Neuwirth, R Ponsillo, M Cakana, AZ King, J Deraedt, WM Desai, A Lutska, Y Gifkins, D Liu, K Sonneveld, P AF San Miguel, Jesus F. Richardson, Paul G. Orlowski, Robert Z. Goldschmidt, Hartmut Corzo, Deyanira Satler, Carol Esseltine, Dixie-Lee Neuwirth, Rachel Ponsillo, Maria Cakana, Andrew Z. King, Jay Deraedt, William M. Desai, Avinash Lutska, Yana Gifkins, Dina Liu, Kevin Sonneveld, Pieter TI Risk of Second Primary Malignancies (SPMs) Following Bortezomib (Btz)-Based Therapy: Analysis of Four Phase 3 Randomized Controlled Trials in Previously Untreated or Relapsed Multiple Myeloma (MM) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [San Miguel, Jesus F.] Hosp Clin Univ, Salamanca, Spain. [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Orlowski, Robert Z.] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA. [Goldschmidt, Hartmut] Univ Heidelberg, Sekt Multiples Myelom Med Klin 5, Heidelberg, Germany. [Goldschmidt, Hartmut] Univ Heidelberg, NCT, Heidelberg, Germany. [Corzo, Deyanira; Satler, Carol; Esseltine, Dixie-Lee; Neuwirth, Rachel; Ponsillo, Maria] Millennium Pharmaceut Inc, Cambridge, MA USA. [Cakana, Andrew Z.] Janssen Res & Dev, High Wycombe, Bucks, England. [King, Jay; Lutska, Yana; Liu, Kevin] Janssen Res & Dev, Raritan, NJ USA. [Deraedt, William M.] Janssen Res & Dev, Beerse, Belgium. [Desai, Avinash] Janssen Global Serv, Raritan, NJ USA. [Gifkins, Dina] Janssen Res & Dev, Titusville, NJ USA. [Sonneveld, Pieter] Erasmus MC, Dept Hematol, Rotterdam, Netherlands. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1265 EP 1265 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104284 ER PT J AU Treon, SP Tripsas, CK Ioakimidis, L Warren, D Patterson, C Heffner, L Eradat, H Gregory, SA Thomas, S Advani, R Baz, R Badros, AZ Matous, J Anderson, KC Ghobrial, IM AF Treon, Steven P. Tripsas, Christina K. Ioakimidis, Leukothea Warren, Diane Patterson, Christopher Heffner, Leonard Eradat, Herbert Gregory, Stephanie A. Thomas, Sheeba Advani, Ranjana Baz, Rachid Badros, Ashraf Z. Matous, Jeffrey Anderson, Kenneth C. Ghobrial, Irene M. TI Prospective, Multicenter Study of the MTOR Inhibitor Everolimus (RAD001) As Primary Therapy in Waldenstrom's Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Treon, Steven P.; Tripsas, Christina K.; Anderson, Kenneth C.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Ioakimidis, Leukothea; Patterson, Christopher] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Warren, Diane] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Heffner, Leonard] Emory Univ, Sch Med, Emory Winship Canc Inst, Atlanta, GA USA. [Eradat, Herbert] UCLA Sch Med, Los Angeles, CA USA. [Gregory, Stephanie A.] Rush Univ, Rush Canc Ctr, Med Ctr, Chicago, IL 60612 USA. [Thomas, Sheeba] UT MD Anderson Canc Ctr, Houston, TX USA. [Advani, Ranjana] Stanford Univ, Stanford, CA 94305 USA. [Baz, Rachid] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL 33612 USA. [Badros, Ashraf Z.] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 21201 USA. [Matous, Jeffrey] Rocky Mt Canc Ctr, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1273 EP 1274 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104302 ER PT J AU Tolar, J Deeg, HJ Arai, S Horwitz, M Antin, JH McCarty, JM Adams, RH Eapen, M Ewell, M Leifer, E Gersten, I Carter, SL Horowitz, MM Confer, DL Nakamura, R Pulsipher, M DiFronzo, NL Anderlini, P AF Tolar, Jakub Deeg, H. Joachim Arai, Sally Horwitz, Mitchell Antin, Joseph H. McCarty, John M. Adams, Roberta H. Eapen, Mary Ewell, Marian Leifer, Eric Gersten, Iris Carter, Shelly L. Horowitz, Mary M. Confer, Dennis L. Nakamura, Ryotaro Pulsipher, Michael DiFronzo, Nancy L. Anderlini, Paolo TI Fludarabine-Based Conditioning for Allogeneic Marrow Transplantation From Unrelated Donors in Severe Aplastic Anemia (SAA): Serious and Unexpected Adverse Events in Pre-Defined Cyclophosphamide (CY) Dose Levels SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Tolar, Jakub] Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Mason Canc Ctr, Minneapolis, MN 55455 USA. [Deeg, H. Joachim] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Arai, Sally] Stanford Univ, Med Ctr, Stanford, CA 94305 USA. [Horwitz, Mitchell] Duke Univ, Med Ctr, Durham, NC USA. [Antin, Joseph H.] Brigham & Womens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. [McCarty, John M.] Virginia Commonwealth Univ, Med Coll Virginia, VCU Hlth Syst, Richmond, VA 23298 USA. [Adams, Roberta H.] Mayo Clin Arizona, Div Hematol & Med Oncol, Scottsdale, AZ USA. [Horowitz, Mary M.] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. [Ewell, Marian; Gersten, Iris; Carter, Shelly L.] EMMES Corp, Rockville, MD USA. [DiFronzo, Nancy L.] NHLBI, Blood Div, Bethesda, MD 20892 USA. [Confer, Dennis L.] Natl Marrow Donor Program, Minneapolis, MN USA. [Nakamura, Ryotaro] City Hope Natl Med Ctr, Dept Hematol HCT, Duarte, CA USA. [Pulsipher, Michael] Univ Utah, Med Ctr, Salt Lake City, UT USA. [Anderlini, Paolo] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1296 EP 1296 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104360 ER PT J AU Omer, AK Yalamarti, B Kim, H McAfee, SL Dey, BR Ballen, KK Attar, EC Chen, YBA Spitzer, TR AF Omer, Aazim Kamal Yalamarti, Bhargavi Kim, Haesook McAfee, Steven L. Dey, Bimalangshu R. Ballen, Karen K. Attar, Eyal C. Chen, Yi-Bin A. Spitzer, Thomas R. TI Engraftment Syndrome After Allogeneic Hematopoietic Cell Transplantation: Relationship to Acute Gvhd and Impact on Transplant Outcomes SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Omer, Aazim Kamal] N Shore Med Ctr, Salem, MA USA. [Yalamarti, Bhargavi] Mt Auburn Hosp, Cambridge, MA USA. [Kim, Haesook] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [McAfee, Steven L.; Dey, Bimalangshu R.; Ballen, Karen K.; Attar, Eyal C.; Chen, Yi-Bin A.] Massachusetts Gen Hosp, Bone Marrow Transplant Unit, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1298 EP 1298 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104364 ER PT J AU Armand, P Sainvil, MM Kim, HT Rhodes, J Cutler, C Ho, VT Koreth, J Alyea, EP Neufeld, EJ Kwong, RY Soiffer, RJ Antin, JH AF Armand, Philippe Sainvil, Marie-Michele Kim, Haesook T. Rhodes, Joanna Cutler, Corey Ho, Vincent T. Koreth, John Alyea, Edwin P., III Neufeld, Ellis J. Kwong, Raymond Y. Soiffer, Robert J. Antin, Joseph H. TI Does Iron Overload Really Matter in Stem Cell Transplantation? SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Armand, Philippe; Sainvil, Marie-Michele; Kim, Haesook T.; Cutler, Corey; Ho, Vincent T.; Koreth, John; Alyea, Edwin P., III; Soiffer, Robert J.; Antin, Joseph H.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Rhodes, Joanna] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA. [Neufeld, Ellis J.] Harvard Univ, Childrens Hosp, Boston, MA 02115 USA. [Kwong, Raymond Y.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1305 EP 1306 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104380 ER PT J AU Mitsuma, S Licona, J Lynch, R Sievers, A Cutler, C Koreth, J Ho, VT Armand, P Alyea, EP Antin, JH Soiffer, RJ Marty, FM AF Mitsuma, Sheila Licona, Jose Lynch, Robert Sievers, Amy Cutler, Corey Koreth, John Ho, Vincent T. Armand, Philippe Alyea, Edwin P., III Antin, Joseph H. Soiffer, Robert J. Marty, Francisco M. TI Pre-Emptive Rituximab for the Prevention of EBV-Related PTLD in Umbilical Cord Blood Transplantion Patients SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Mitsuma, Sheila; Licona, Jose; Lynch, Robert; Marty, Francisco M.] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Cutler, Corey; Koreth, John; Ho, Vincent T.; Armand, Philippe; Alyea, Edwin P., III; Antin, Joseph H.; Soiffer, Robert J.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1306 EP 1307 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104382 ER PT J AU Jacobson, CA Kim, HT Sarantopoulos, S Sun, LX McDonough, S Reynolds, CG Herrera, MI Koreth, J Cutler, CS Ho, VT Alyea, EP Armand, P Soiffer, RJ Antin, JH Ritz, J AF Jacobson, Caron A. Kim, Haesook T. Sarantopoulos, Stefanie Sun, Lixian McDonough, Sean Reynolds, Carol G. Herrera, Maria I. Koreth, John Cutler, Corey S. Ho, Vincent T. Alyea, Edwin P., III Armand, Philippe Soiffer, Robert J. Antin, Joseph H. Ritz, Jerome TI Patterns of B Cell Activating Factor (BAFF) Levels, B Cell Recovery, and BAFF/B Cell Ratios Correlate with the Development of Chronic Graft-Versus-Host Disease (cGVHD) Following Hematopoietic Stem Cell Transplantation (HSCT) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Jacobson, Caron A.; Koreth, John; Cutler, Corey S.; Ho, Vincent T.; Alyea, Edwin P., III; Soiffer, Robert J.; Antin, Joseph H.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Kim, Haesook T.] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Sarantopoulos, Stefanie] Univ N Carolina, Sch Med, Div Hematol Oncol, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA. [Armand, Philippe] Dana Farber Brigham & Womens Canc Ctr, Div Hematol Malignancies, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1308 EP 1309 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104387 ER PT J AU Battiwalla, M Ellis, K Pavletic, SZ Akpek, G Hematti, P Klumpp, TR Maziarz, RT Savani, BN Aljurf, M Cairo, MS Drobyski, WR George, B Hahn, T Khera, N Litzow, MR Loren, AW Saber, W Arora, M Urbano-Ispizua, A Cutler, CS Flowers, MED Spellman, S AF Battiwalla, Minoo Ellis, Kristin Pavletic, Steven Z. Akpek, Gorgun Hematti, Peiman Klumpp, Thomas R. Maziarz, Richard T. Savani, Bipin N. Aljurf, Mahmoud Cairo, Mitchell S. Drobyski, William R. George, Biju Hahn, Theresa Khera, Nandita Litzow, Mark R. Loren, Alison W. Saber, Wael Arora, Mukta Urbano-Ispizua, Alvaro Cutler, Corey S. Flowers, Mary E. D. Spellman, Stephen TI HLA DR15 Antigen Status Does Not Impact Graft-Versus-Host Disease or Disease-Free Survival in HLA-Matched Sibling Transplantation for Hematologic Malignancies SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Battiwalla, Minoo] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA. [Ellis, Kristin; Saber, Wael] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. [Pavletic, Steven Z.] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Akpek, Gorgun] Univ Maryland, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA. [Hematti, Peiman] Univ Wisconsin, Sch Med & Publ Hlth, Clin Sci Ctr H4 534, Madison, WI USA. [Maziarz, Richard T.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Savani, Bipin N.] Vanderbilt Univ, Med Ctr, Dept Med, Hematol & Stem Cell Transplantat Sect,Div Hematol, Nashville, TN USA. [Aljurf, Mahmoud] King Faisal Specialist Hosp & Res Ctr, Ctr Oncol, Riyadh 11211, Saudi Arabia. [Cairo, Mitchell S.] New York Med Coll, Valhalla, NY 10595 USA. [George, Biju] Christian Med Coll & Hosp, Dept Haematol, Vellore, Tamil Nadu, India. [Hahn, Theresa] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA. [Khera, Nandita; Flowers, Mary E. D.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Litzow, Mark R.] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA. [Loren, Alison W.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Arora, Mukta] Univ Minnesota, Minneapolis, MN USA. [Urbano-Ispizua, Alvaro] Hosp Clin Barcelona, Barcelona, Spain. [Cutler, Corey S.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Spellman, Stephen] Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1337 EP 1337 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104445 ER PT J AU Querbes, W Bogorad, R Moslehi, J Akinc, A Wong, J Zurenko, C Qin, J Hettinger, J Kuchimanchi, S Charisse, K Sah, DWY Fitzgerald, K Kotelianski, V Kaelin, WG AF Querbes, William Bogorad, Roman Moslehi, Javid Akinc, Akin Wong, Jamie Zurenko, Chris Qin, June Hettinger, Julia Kuchimanchi, Satya Charisse, Klaus Sah, Dinah W. Y. Fitzgerald, Kevin Kotelianski, Victor Kaelin, William G., Jr. TI Liver Specific Delivery of siRNA Targeting EGLN Prolyl Hydroxylases Activates Hepatic Erythropoietin Production and Stimulates Erythropoiesis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Querbes, William; Akinc, Akin; Wong, Jamie; Zurenko, Chris; Qin, June; Hettinger, Julia; Kuchimanchi, Satya; Charisse, Klaus; Sah, Dinah W. Y.; Fitzgerald, Kevin; Kotelianski, Victor] Alnylam Pharmaceut, Cambridge, MA USA. [Bogorad, Roman] MIT, David Koch Inst Canc Res, Cambridge, MA 02139 USA. [Moslehi, Javid] Dana Farber Canc Inst, Boston, MA 02115 USA. [Kaelin, William G., Jr.] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dana Farber Canc Ctr, Boston, MA 02115 USA. RI Bogorad, Roman/G-2609-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1366 EP 1366 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104511 ER PT J AU Kuter, DJ Mehta, A Hollak, C Giraldo, P Hughes, D Belmatoug, N Brand, M Muller, A Schaaf, B Giorgino, R Zimran, A AF Kuter, David J. Mehta, Atul Hollak, Carla Giraldo, Pilar Hughes, Derralynn Belmatoug, Nadia Brand, Monika Muller, Audrey Schaaf, Berthold Giorgino, Ruben Zimran, Ari TI Miglustat Therapy in Type 1 Gaucher Disease: Long-Term Treatment Experience From a Multicenter, Retrospective Cohort Study SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kuter, David J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Mehta, Atul; Hughes, Derralynn] Royal Free Hosp, London NW3 2QG, England. [Mehta, Atul; Hughes, Derralynn] UCL, Sch Med, London W1N 8AA, England. [Hollak, Carla] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands. [Giraldo, Pilar] Minist Publ Hlth Russia, Hematol Res Ctr, Moscow, Russia. [Belmatoug, Nadia] Hop Beaujon, Clichy, France. [Brand, Monika; Muller, Audrey; Giorgino, Ruben] Actel Pharmaceut, Allschwil, Switzerland. [Schaaf, Berthold] Factum, Offenbach, Germany. [Zimran, Ari] Shaare Zedek Med Ctr, Jerusalem, Israel. RI Hughes, Derralynn/J-8012-2013 OI Hughes, Derralynn/0000-0003-4531-9173 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1385 EP 1385 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104557 ER PT J AU Peterschmitt, MJ Kamath, RS Lukina, E Watman, N Dragosky, M Iastrebner, M Pastores, GM Arreguin, EA Phillips, M Rosenbaum, H Sysoeva, E Aguzzi, R Ross, LH Puga, AC Rosenthal, DI AF Peterschmitt, M. Judith Kamath, Ravi S. Lukina, Elena Watman, Nora Dragosky, Marta Iastrebner, Marcelo Pastores, Gregory M. Avila Arreguin, Elsa Phillips, Mici Rosenbaum, Hanna Sysoeva, Elena Aguzzi, Rasha Ross, Leorah H. Puga, Ana Cristina Rosenthal, Daniel I. TI Improvements in Skeletal Manifestations in Gaucher Disease Type 1 Patients After 3 Years of Treatment with Oral Eliglustat During a Phase 2 Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Peterschmitt, M. Judith; Aguzzi, Rasha; Ross, Leorah H.; Puga, Ana Cristina] Genzyme, Cambridge, MA USA. [Kamath, Ravi S.; Rosenthal, Daniel I.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Lukina, Elena; Sysoeva, Elena] Minist Publ Hlth Russia, Hematol Res Ctr, Moscow, Russia. [Watman, Nora] Hosp Ramos Mejia, Buenos Aires, DF, Argentina. [Dragosky, Marta; Iastrebner, Marcelo] Inst Argentino Diagnost & Tratamiento, Buenos Aires, DF, Argentina. [Pastores, Gregory M.] NYU, New York, NY USA. [Avila Arreguin, Elsa] Hosp Especialidades Ctr Med La Raza, Inst Mexican Seguro Social, Mexico City, DF, Mexico. [Phillips, Mici] Shaare Zedek Med Ctr, Jerusalem, Israel. [Rosenbaum, Hanna] Technion Israel Inst Technol, Rambam Med Ctr, Haifa, Israel. [Rosenbaum, Hanna] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel. RI Sysoeva, Elena/N-4819-2014 OI Sysoeva, Elena/0000-0002-5056-9540 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1389 EP 1389 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104566 ER PT J AU Kadoch, C Wong, V Chen, LJ Bet-Lachin, A Roy, R Hyun, W Behler, C Lowell, C Rubenstein, JL AF Kadoch, Cicall Wong, Valerie Chen, Lingjing Bet-Lachin, Anna Roy, Ritu Hyun, William Behler, Caroline Lowell, Clifford Rubenstein, James L. TI Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Roy, Ritu] UCSF, Ctr Comprehens Canc, San Francisco, CA USA. [Behler, Caroline] San Francisco VA Med Ctr, San Francisco, CA USA. [Lowell, Clifford] Univ CA, San Francisco, CA USA. [Rubenstein, James L.] Univ Calif San Francisco, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1390 EP 1390 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597104569 ER PT J AU Zhu, JQ Choi, WS McCoy, JG Negri, A Zhu, JH Naini, S Li, JH Shen, M Huang, WW Thomas, CJ Filizola, M Springer, T Coller, BS AF Zhu, Jieqing Choi, Won-Seok McCoy, Joshua G. Negri, Ana Zhu, Jianghai Naini, Sarasija Li, Jihong Shen, Min Huang, Wenwei Thomas, Craig J. Filizola, Marta Springer, Timothy Coller, Barry S. TI Structure-Guided Design of A Novel High Affinity Integrin alpha IIb beta 3 Receptor Antagonist (RUC-2) That Displaces Mg2+ From the beta 3 MIDAS SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Zhu, Jieqing; Zhu, Jianghai; Springer, Timothy] Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA USA. [Zhu, Jieqing; Zhu, Jianghai; Springer, Timothy] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA. [Choi, Won-Seok; Naini, Sarasija; Li, Jihong; Coller, Barry S.] Rockefeller Univ, Lab Blood & Vasc Biol, New York, NY 10021 USA. [McCoy, Joshua G.; Shen, Min; Huang, Wenwei; Thomas, Craig J.] NIH Chem Genom Ctr, Bethesda, MD USA. [Negri, Ana; Filizola, Marta] Mt Sinai Sch Med, New York, NY USA. RI Zhu, Jianghai/B-7339-2014 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1401 EP 1402 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597104605 ER PT J AU Makar, R Zhukov, OS Sahud, MA Kuter, DJ AF Makar, Robert Zhukov, Olga S. Sahud, Mervyn A. Kuter, David J. TI Thrombopoietin Levels May Predict Responsiveness to Therapy with Thrombopoietin Agonists Among Patients with Immune Thrombocytopenic Purpura SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Makar, Robert] Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Zhukov, Olga S.; Sahud, Mervyn A.] Quest Diagnost Nichols Inst, San Juan Capistrano, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1414 EP 1414 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105018 ER PT J AU Gunasekera, D Ettinger, RA Hughes, RJ Epstein, MS Barrett, JC Thompson, AA Withycombe, J Pratt, KP AF Gunasekera, Devi Ettinger, Ruth A. Hughes, Richard J. Epstein, Melinda S. Barrett, John C. Thompson, Alexis A. Withycombe, Janice Pratt, Kathleen P. TI Potential Immunogenicity of Amino Acid Sequences Encoded by Ns-SNPs in Factor VIII SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Gunasekera, Devi; Ettinger, Ruth A.; Pratt, Kathleen P.] Puget Sound Blood Ctr, Res Inst, Seattle, WA 98104 USA. [Hughes, Richard J.; Epstein, Melinda S.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Barrett, John C.] Virginia Commonwealth Univ, Cent Virginia Ctr Coagulat Disorders, Richmond, VA USA. [Thompson, Alexis A.] Childrens Mem Hosp, Chicago, IL 60614 USA. [Withycombe, Janice] Palmetto Hlth Childrens Hosp, Columbia, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1430 EP 1431 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597105059 ER PT J AU Nombela-Arrieta, C Pivarnik, G Winkel, B Harley, B Mahoney, JE Lu, JY Protopopov, A Silberstein, LE AF Nombela-Arrieta, Cesar Pivarnik, Gregory Winkel, Beatrice Harley, Brendan Mahoney, John E. Lu, Jiayun Protopopov, Alexei Silberstein, Leslie E. TI Hypoxic Hematopoietic Stem and Progenitor Cells Reside in Structurally Diverse Perivascular Niches in the Bone Marrow SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Pivarnik, Gregory; Silberstein, Leslie E.] Childrens Hosp Boston, Joint Program Transfus Med, Boston, MA USA. [Harley, Brendan] Univ Illinois, Chicago, IL 60680 USA. [Mahoney, John E.; Protopopov, Alexei] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lu, Jiayun] Childrens Hosp Boston, Dept Lab Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1462 EP 1462 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105146 ER PT J AU Sanda, T Lawton, LN Barrasa, MI Fan, ZP Ahn, Y Young, R Look, AT AF Sanda, Takaomi Lawton, Lee N. Barrasa, M. Inmaculada Fan, Zi Peng Ahn, Yebin Young, Richard Look, A. Thomas TI Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Sanda, Takaomi; Ahn, Yebin; Look, A. Thomas] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lawton, Lee N.; Barrasa, M. Inmaculada; Fan, Zi Peng; Young, Richard] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1476 EP 1476 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105182 ER PT J AU Trowbridge, JJ Sinha, AU Armstrong, SA Orkin, SH AF Trowbridge, Jennifer J. Sinha, Amit U. Armstrong, Scott A. Orkin, Stuart H. TI Haploinsufficiency of Dnmt1 Impairs Leukemia Stern Cell Function Through Derepression of Bivalent Chromatin Domains SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Trowbridge, Jennifer J.; Orkin, Stuart H.] Childrens Hosp, Harvard Stem Cell Inst, Howard Hughes Med Inst, Dept Pediat Oncol,Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1478 EP 1479 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597105188 ER PT J AU Evans, E Tester, R Aslanian, S Chaturvedi, P Mazdiyasni, H Ponader, S Tesar, B Sheets, M Nacht, M Stiede, K Witowski, S Lounsbury, H Petter, R Brown, JR Burger, JA Singh, J Westlin, WF AF Evans, Erica Tester, Richland Aslanian, Sharon Chaturvedi, Prasoon Mazdiyasni, Hormoz Ponader, Sabine Tesar, Bethany Sheets, Michael Nacht, Mariana Stiede, Kathryn Witowski, Steve Lounsbury, Heather Petter, Russell Brown, Jennifer R. Burger, Jan A. Singh, Juswinder Westlin, William F. TI Clinical Development of AVL-292; A Potent, Selective Covalent Btk Inhibitor for the Treatment of B Cell Malignancies SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Evans, Erica; Tester, Richland; Aslanian, Sharon; Chaturvedi, Prasoon; Mazdiyasni, Hormoz; Sheets, Michael; Nacht, Mariana; Stiede, Kathryn; Witowski, Steve; Lounsbury, Heather; Petter, Russell; Westlin, William F.] Avila Therapeut, Bedford, MA USA. [Ponader, Sabine; Burger, Jan A.] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA. [Tesar, Bethany; Brown, Jennifer R.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Singh, Juswinder] Avila Therapeut Inc, Bedford, MA USA. NR 0 TC 2 Z9 2 U1 1 U2 9 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1487 EP 1487 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105214 ER PT J AU Herrmann, H Blatt, K Shi, JW Rappaport, AR Gleixner, KV Cerny-Reiterer, S Peter, B Wang, E Sperr, WR Bradner, JE Lowe, SW Vakoc, CR Zuber, J Valent, P AF Herrmann, Harald Blatt, Katharina Shi, Junwei Rappaport, Amy R. Gleixner, Karoline V. Cerny-Reiterer, Sabine Peter, Barbara Wang, Eric Sperr, Wolfgang R. Bradner, James E. Lowe, Scott W. Vakoc, Christopher R. Zuber, Johannes Valent, Peter TI Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Herrmann, Harald; Peter, Barbara] Ludwig Boltzmann Cluster Oncol, Vienna, Austria. [Blatt, Katharina; Gleixner, Karoline V.; Cerny-Reiterer, Sabine; Sperr, Wolfgang R.; Valent, Peter] Med Univ Vienna, Div Hematol & Hemostaseol, Dept Internal Med 1, Vienna, Austria. [Shi, Junwei; Rappaport, Amy R.; Wang, Eric; Lowe, Scott W.; Vakoc, Christopher R.; Zuber, Johannes] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA. [Bradner, James E.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1487 EP 1487 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105213 ER PT J AU Buitenkamp, T Izraeli, S Zimmermann, M Forestier, E Heerema, NA van den Heuvel, MM Pieters, R de Haas, V Silverman, LB Schmiegelow, K Liang, DC Horibe, K Arico, M Cazzaniga, G Basso, G Rabin, KR Schrappe, M Cario, G Mann, G Mondelaers, V Lammens, T Cave, H Stark, B Moorman, AV Vora, AJ Hunger, S Pui, CH Mullighan, CG Manabe, A Escherich, G Kowalczyk, J Whitlock, JA Zwaan, CM AF Buitenkamp, Trudy Izraeli, Shai Zimmermann, Martin Forestier, Erik Heerema, Nyla A. van den Heuvel, Marry M. Pieters, Rob de Haas, Valerie Silverman, Lewis B. Schmiegelow, Kjeld Liang, Der-Cherng Horibe, Keizo Arico, Maurizio Cazzaniga, Giovanni Basso, Giuseppe Rabin, Karen R. Schrappe, Martin Cario, Gunnar Mann, Georg Mondelaers, Veerle Lammens, Tim Cave, Helene Stark, Batia Moorman, Anthony V. Vora, Ajay J. Hunger, Stephen Pui, Ching-Hon Mullighan, Charles G. Manabe, Atsushi Escherich, Gabriele Kowalczyk, Jerzy Whitlock, James A. Zwaan, Christian M. TI Acute Lymphoblastic Leukemia in Children with Down Syndrome: A Report From the Ponte Di Legno Study Group SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Buitenkamp, Trudy; van den Heuvel, Marry M.; Pieters, Rob; Zwaan, Christian M.] Erasmus MC Sophia Childrens Hosp, Rotterdam, Netherlands. [Izraeli, Shai] Tel Aviv Univ, IL-69978 Tel Aviv, Israel. [Izraeli, Shai] Sheba Med Ctr, Ramat Gan, Israel. [Zimmermann, Martin] Hannover Med Sch, D-30623 Hannover, Germany. [Forestier, Erik] Umea Univ, Departement Med Biosci, Umea, Sweden. [Heerema, Nyla A.] Ohio State Univ, Columbus, OH 43210 USA. [de Haas, Valerie] Dutch Childhood Oncol Grp DCOG, The Hague, Netherlands. [Silverman, Lewis B.] Childrens Hosp Boston, Dana Farber Canc Inst, Boston, MA USA. [Schmiegelow, Kjeld] Univ Hosp Rigshosp, Copenhagen, Denmark. [Liang, Der-Cherng] Mackay Mem Hosp, Taipei, Taiwan. [Horibe, Keizo] Natl Hosp Org Nagoya Med Ctr, Clin Res Ctr, Nagoya, Aichi, Japan. [Arico, Maurizio] Osepedale Meyer, Florence, Italy. [Cazzaniga, Giovanni] Univ Milano Bicocca, Pediat Clin, M Tettamanti Res Ctr, Monza, Italy. [Basso, Giuseppe] Univ Padua, Padua, Italy. [Rabin, Karen R.] Texas Childrens Canc Ctr, Houston, TX USA. [Schrappe, Martin] Univ Med Ctr Schleswig Holstein, Dept Pediat, Kiel, Germany. [Cario, Gunnar] Univ Med Ctr Schleswig Holstein, Dept Paediat, Kiel, Germany. [Mann, Georg] St Anna Childrens Hosp, Vienna, Austria. [Mann, Georg] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria. [Mondelaers, Veerle; Lammens, Tim] Ghent Univ Hosp, Dept Pediat Hematooncol, Ghent, Belgium. [Cave, Helene] Hop Robert Debre, Dept Genet, F-75019 Paris, France. [Stark, Batia] Schneider Childrens Med Ctr Israel, Tel Aviv, Israel. [Moorman, Anthony V.] Newcastle Univ, No Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. [Vora, Ajay J.] Sheffield Childrens Hosp, Dept Pediat Hematol, Sheffield S10 2TH, S Yorkshire, England. [Hunger, Stephen] Univ Colorado, Sch Med, Pediat Hem Onc BMT, Aurora, CO USA. [Pui, Ching-Hon; Mullighan, Charles G.] St Jude Childrens Hosp, Memphis, TN 38105 USA. [Manabe, Atsushi] St Lukes Int Hosp, Dept Pediat, Tokyo, Japan. [Escherich, Gabriele] Zentrum Frauen Kinder & Jugendmed, Hamburg, Germany. [Kowalczyk, Jerzy] Med Univ, Lublin, Poland. [Whitlock, James A.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1527 EP 1528 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597105308 ER PT J AU Fernandez, HF Sun, ZX Litzow, MR Luger, SM Paietta, E Racevskis, J Dewald, GW Ketterling, RP Bennett, JM Rowe, JM Lazarus, HM Tallman, MS AF Fernandez, Hugo F. Sun, Zhuoxin Litzow, Mark R. Luger, Selina M. Paietta, Elisabeth Racevskis, Janis Dewald, Gordon W. Ketterling, Rhett P. Bennett, John M. Rowe, Jacob M. Lazarus, Hillard M. Tallman, Martin S. TI Young Adults Presenting with Extramedullary Acute Myeloid Leukemia Have A Unique Sensitivity to High Doses of Anthracyclines: Subset Analysis of ECOG 1900 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Fernandez, Hugo F.] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Blood & Marrow Transplantat, Tampa, FL 33682 USA. [Sun, Zhuoxin] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Litzow, Mark R.] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA. [Luger, Selina M.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Racevskis, Janis] Montefiore Med Ctr, North Div, Bronx, NY 10467 USA. [Ketterling, Rhett P.] Mayo Clin, Dept Lab Med, Cytogenet Div, Rochester, MN USA. [Bennett, John M.] Univ Rochester, Rochester, NY USA. [Rowe, Jacob M.] Technion Israel Inst Technol, Rambam Med Ctr, Haifa, Israel. [Lazarus, Hillard M.] Univ Hosp Case Med Ctr, Cleveland, OH USA. [Tallman, Martin S.] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10021 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1546 EP 1546 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105348 ER PT J AU Forrester, AM Coombs, AJ McBride, ER Chute, I Leger, D Lewis, S Grabher, C Look, T Berman, JN AF Forrester, A. Michael Coombs, Andrew J. McBride, Eileen R. Chute, Ian Leger, Daniel Lewis, Stephen Grabher, Clemens Look, Thomas Berman, Jason N. TI NUP98-HOXA9 drives High-Risk Myeloid Disease in Zebrafish - An In Vivo platform to Study Interacting Genes and Perform Drug Discovery SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Chute, Ian; Leger, Daniel] Atlantic Canc Res Inst, Moncton, NB, Canada. [Grabher, Clemens] Karlsruhe Inst Technol, Inst Toxicol & Genet, Karlsruhe, Germany. [Look, Thomas] Dana Farber Canc Inst, Boston, MA 02115 USA. [Coombs, Andrew J.; McBride, Eileen R.; Berman, Jason N.] Dalhousie Univ, IWK Hlth Ctr, Halifax, NS, Canada. NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1547 EP 1547 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105351 ER PT J AU Kostakoglu, L Schoder, H Hall, N Straus, DJ Johnson, JL Schwartz, L LaCasce, A Jung, SH Bartlett, NL Canellos, GP Cheson, BD AF Kostakoglu, Lale Schoder, Heiko Hall, Nathan Straus, David J. Johnson, Jeffrey L. Schwartz, Lawrence LaCasce, Ann Jung, Sin-Ho Bartlett, Nancy L. Canellos, George P. Cheson, Bruce D. TI Interim FDG PET Imaging in CALGB 50203 Trial of Stage I/II Non-Bulky Hodgkin Lymphoma: Would Using Combined PET and CT Criteria Better Predict Response Than Each Test Alone? SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Kostakoglu, Lale] Mt Sinai Med Ctr, Dept Radiol, New York, NY 10029 USA. [Straus, David J.] Mem Sloan Kettering Canc Ctr, Lymphoma Serv, Dept Med, New York, NY 10021 USA. [Hall, Nathan] Ohio State Univ, Columbus, OH 43210 USA. [Johnson, Jeffrey L.; Jung, Sin-Ho] Duke Univ, Med Ctr, CALGB Stat Ctr, Durham, NC USA. [Schwartz, Lawrence] Columbia Univ, Med Ctr, New York, NY USA. [LaCasce, Ann; Canellos, George P.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Bartlett, Nancy L.] Washington Univ, Sch Med, St Louis, MO USA. [Cheson, Bruce D.] Georgetown Univ Hosp, Div Hematol & Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1556 EP 1556 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105373 ER PT J AU Rombaoa, CP Zhang, Y Banwait, R Liu, Y Ngobs, HT Quang, P Azab, AK Azab, F Maiso, P Reagan, M Sacco, A Roccaro, AM Brown, JR Ghobrial, IM AF Rombaoa, Christopher P. Zhang, Yong Banwait, Ranjit Liu, Yang NgoBs, Hai T. Quang, Phong Azab, Abdel Kareem Azab, Feda Maiso, Patricia Reagan, Michaela Sacco, Antonio Roccaro, Aldo M. Brown, Jennifer R. Ghobrial, Irene M. TI MicroRNA-155 As a Potential Plasma Biomarker for Chronic Lymphocytic Leukemia and Waldenstrom Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Rombaoa, Christopher P.; Zhang, Yong; Banwait, Ranjit; Liu, Yang; NgoBs, Hai T.; Quang, Phong; Azab, Abdel Kareem; Azab, Feda; Maiso, Patricia; Reagan, Michaela; Sacco, Antonio; Roccaro, Aldo M.; Brown, Jennifer R.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Reagan, Michaela/E-3549-2017 NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1568 EP 1569 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597105397 ER PT J AU Weigert, O Kopp, N Lane, AA Yoda, A Dahlberg, SE Neuberg, D Bahar, AY Chapuy, B Kuo, F Haley, T Sullivan, TJ Fox, E Rodig, SJ Antin, JH Weinstock, DM AF Weigert, Oliver Kopp, Nadja Lane, Andrew A. Yoda, Akinori Dahlberg, Suzanne E. Neuberg, Donna Bahar, Anita Y. Chapuy, Bjoern Kuo, Frank Haley, Terry Sullivan, Timothy J. Fox, Edward Rodig, Scott J. Antin, Joseph H. Weinstock, David M. TI Molecular Ontogeny of Donor-Derived Lymphomas Occurring After Transplantation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Bahar, Anita Y.; Kuo, Frank; Rodig, Scott J.] Dana Farber Canc Inst, Dept Pathol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1569 EP 1569 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105399 ER PT J AU Hong, FX Kahl, BS Gray, R AF Hong, Fangxin Kahl, Brad S. Gray, Robert TI Incremental Value in Outcome Prediction with Molecular Signatures in Diffuse Large B-Cell Lymphoma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Hong, Fangxin; Gray, Robert] Dana Farber Canc Inst, Boston, MA 02115 USA. [Kahl, Brad S.] Univ Wisconsin, Dept Med Hematol Oncol, Madison, WI USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1575 EP 1576 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597105415 ER PT J AU Paba-Prada, CE Banwait, R Treon, S Ghobrial, IM AF Paba-Prada, Claudia E. Banwait, Ranjit Treon, Steven Ghobrial, Irene M. TI Incidence of Peripheral Neuropathy in Waldenstrom Macroglobulinemia Patients At Diagnosis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Paba-Prada, Claudia E.; Banwait, Ranjit; Treon, Steven; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1577 EP 1577 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105420 ER PT J AU Fanale, M Bensinger, WI Byrd, JC Ewald, B Carreon, D Baeck, J Freedman, AS AF Fanale, Michelle Bensinger, William I. Byrd, John C. Ewald, Brett Carreon, Daniel Baeck, Johan Freedman, Arnold S. TI Multi-Trial Safety Evaluation of the Fully Antagonistic Human Anti-CD40 Monoclonal Antibody Lucatumumab (HCD122) in Patients with Relapsed or Refractory B-Cell Malignancies SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Fanale, Michelle] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Bensinger, William I.] Fred Hutchinson Canc Res Ctr, Clin Div, Seattle, WA 98104 USA. [Byrd, John C.] Ohio State Univ, Div Hematol, Columbus, OH 43210 USA. [Ewald, Brett; Carreon, Daniel; Baeck, Johan] Novartis Pharmaceut, E Hanover, NJ USA. [Freedman, Arnold S.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1581 EP 1581 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105430 ER PT J AU Barnes, JA Stevenson, K Hochberg, EP Takvorian, T Fisher, DC LaCasce, A Brown, JR Mahindra, AK Neuberg, D Abramson, JS AF Barnes, Jeffrey A. Stevenson, Kristen Hochberg, Ephraim P. Takvorian, Tak Fisher, David C. LaCasce, Ann Brown, Jennifer R. Mahindra, Anuj K. Neuberg, Donna Abramson, Jeremy S. TI Increased Dose Rituximab Followed by Maintenance Rituximab As Initial Therapy for Indolent B Cell Lymphomas: A Phase II Trial SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Barnes, Jeffrey A.; Hochberg, Ephraim P.; Takvorian, Tak; Mahindra, Anuj K.; Abramson, Jeremy S.] Massachusetts Gen Hosp, Ctr Canc, Ctr Lymphoma, Boston, MA USA. [Stevenson, Kristen; Neuberg, Donna] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [LaCasce, Ann; Brown, Jennifer R.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1587 EP 1588 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597105444 ER PT J AU Pardanani, A Gotlib, J Jamieson, C Cortes, JE Talpaz, M Stone, R Gao, GZ Zhang, J Neumann, F Tefferi, A AF Pardanani, Animesh Gotlib, Jason Jamieson, Catriona Cortes, Jorge E. Talpaz, Moshe Stone, Richard Gao, Guozhi Zhang, Jenny (Yanzhen) Neumann, Frank Tefferi, Ayalew TI SAR302503: Interim Safety, Efficacy and Long-Term Impact on JAK2 V617F Allele Burden in a Phase I/II Study in Patients with Myelofibrosis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Pardanani, Animesh; Tefferi, Ayalew] Mayo Clin, Div Hematol, Dept Internal Med, Rochester, MN USA. [Gotlib, Jason] Stanford Univ, Div Hematol, Sch Med, Stanford, CA 94305 USA. [Gotlib, Jason] Stanford Univ, Div Oncol, Sch Med, Stanford, CA 94305 USA. [Gotlib, Jason] Stanford Univ, Sch Med, Stanford Canc Ctr, Stanford, CA 94305 USA. [Jamieson, Catriona] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Jamieson, Catriona] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. [Cortes, Jorge E.] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA. [Talpaz, Moshe] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA. [Stone, Richard] Dana Farber Canc Inst, Boston, MA 02115 USA. [Zhang, Jenny (Yanzhen); Neumann, Frank] Sanofi Aventis, Cambridge, MA USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1640 EP 1640 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106008 ER PT J AU Pardanani, A Gotlib, J Gupta, V Roberts, AW Wadleigh, M Sirhan, S Litzow, MR Hogan, WJ Begna, K Smith, G Bavisotto, LM Kowalski, M Tefferi, A AF Pardanani, Animesh Gotlib, Jason Gupta, Vikas Roberts, Andrew W. Wadleigh, Martha Sirhan, Shireen Litzow, Mark R. Hogan, William J. Begna, Kebede Smith, Gregg Bavisotto, Linda M. Kowalski, Mark Tefferi, Ayalew TI An Expanded Multicenter Phase I/II Study of CYT387, a JAK-1/2 Inhibitor for the Treatment of Myelofibrosis SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Pardanani, Animesh; Begna, Kebede; Tefferi, Ayalew] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA. [Gotlib, Jason] Stanford Univ, Sch Med, Div Hematol, Stanford, CA 94305 USA. [Gotlib, Jason] Stanford Univ, Sch Med, Div Oncol, Stanford, CA 94305 USA. [Gotlib, Jason] Stanford Univ, Sch Med, Stanford Canc Ctr, Stanford, CA 94305 USA. [Gupta, Vikas] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada. [Roberts, Andrew W.] Royal Melbourne Hosp, BMT, Parkville, Vic 3050, Australia. [Wadleigh, Martha] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Sirhan, Shireen] McGill Univ, Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada. [Hogan, William J.] Mayo Clin, Div Hematol, Rochester, MN USA. [Smith, Gregg; Kowalski, Mark] YM Biosci Inc, Mississauga, ON, Canada. [Bavisotto, Linda M.] Porta Clin, Seattle, WA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1645 EP 1645 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106019 ER PT J AU Ghia, EM Werner, L James, DF Neuberg, D Corral, LG Rassenti, LZ Croce, CM Kipps, TJ AF Ghia, Emanuela M. Werner, Lillian James, Danelle F. Neuberg, Donna Corral, Laura G. Rassenti, Laura Z. Croce, Carlo M. Kipps, Thomas J. TI Treatment of Chronic Lymphocytic Leukemia Patients with Lenalidomide Induces Down-Regulation of miR342-3p Associated with Over-Expression of Tumor Suppressor RASSF4 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [James, Danelle F.] Univ Calif San Diego, Moores UCSD Canc Ctr, Div Hematol & Oncol, San Diego, CA 92103 USA. [Werner, Lillian; Neuberg, Donna] Dana Farber Canc Inst, Boston, MA 02115 USA. [James, Danelle F.] UCSD, La Jolla, CA USA. [Corral, Laura G.] Celgene Corp, San Diego, CA USA. [Croce, Carlo M.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1660 EP 1661 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106055 ER PT J AU Rassenti, LZ Ghia, EM Werner, L Neuberg, D Widhopf, GF Kipps, TJ AF Rassenti, Laura Z. Ghia, Emanuela M. Werner, Lillian Neuberg, Donna Widhopf, George F., II Kipps, Thomas J. TI Relative Prognostic Significance of ZAP-70 and IGHV1-69 Expression in Chronic Lymphocytic Leukemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Rassenti, Laura Z.; Ghia, Emanuela M.; Widhopf, George F., II; Kipps, Thomas J.] Univ Calif San Diego, Moores UCSD Canc Ctr, San Diego, CA 92103 USA. [Werner, Lillian; Neuberg, Donna] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1663 EP 1663 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106061 ER PT J AU Azab, AK Azab, F Quang, P Maiso, P Ngo, HT Zimmermann, J Patel, K Romagnoli, B Sacco, A Liu, Y Zhang, Y Reagan, M Roccaro, AM Ghobrial, IM AF Azab, Abdel Kareem Azab, Feda Quang, Phong Maiso, Patricia Ngo, Hai T. Zimmermann, Johann Patel, Kalpana Romagnoli, Barbara Sacco, Antonio Liu, Yang Zhang, Yong Reagan, Michaela Roccaro, Aldo M. Ghobrial, Irene M. TI Dissecting the role of CXCR7 in Cell Trafficking of Endothelial-Cells and Endothelial-Progenitor-Cells in Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Azab, Abdel Kareem; Azab, Feda; Quang, Phong; Maiso, Patricia; Ngo, Hai T.; Sacco, Antonio; Liu, Yang; Zhang, Yong; Reagan, Michaela; Roccaro, Aldo M.; Ghobrial, Irene M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Zimmermann, Johann; Patel, Kalpana; Romagnoli, Barbara] Polyphor Ltd, Allschwil, Switzerland. RI Reagan, Michaela/E-3549-2017 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1681 EP 1682 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106104 ER PT J AU D'Souza, S Kurihara, N Shiozawa, Y Joseph, J Taichman, R Galson, D Roodman, D AF D'Souza, Sonia Kurihara, Noriyoshi Shiozawa, Yusuke Joseph, Jeena Taichman, Russell Galson, Deborah Roodman, David TI Annexin II Interactions with the Annexin II Receptor Enhance Multiple Myeloma Cell Adhesion and Growth in the Bone Marrow Microenvironment SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [D'Souza, Sonia; Kurihara, Noriyoshi; Galson, Deborah] Univ Pittsburgh, Bone Biol Ctr, UPMC, Pittsburgh, PA USA. [D'Souza, Sonia; Kurihara, Noriyoshi; Galson, Deborah] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Shiozawa, Yusuke; Joseph, Jeena; Taichman, Russell] Univ Michigan, Ann Arbor, MI 48109 USA. [Roodman, David] Univ Pittsburgh, Sch Med, Dept Med, Div Hematol Oncol, Pittsburgh, PA USA. [Roodman, David] Inst Canc Res, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1685 EP 1685 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106112 ER PT J AU Thomenius, M Cerny, J Lena, R Chonghaile, T Walters, S Lyle, S Nath, R Muthalagu, R Lindsey, K Letai, AG Cardone, M AF Thomenius, Michael Cerny, Jan Lena, Ryan Chonghaile, Triona Walters, Stephanie Lyle, Stephen Nath, Rajneesh Muthalagu, Ramanthan Lindsey, Krumpe Letai, Anthony G. Cardone, Michael TI Using BH3 Profiling As a Predictive Indicator for Myeloma Patient Response to Bortezomib SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Thomenius, Michael; Lena, Ryan; Cardone, Michael] Eutrop Pharmaceut, Cambridge, MA USA. [Cerny, Jan; Nath, Rajneesh; Muthalagu, Ramanthan; Lindsey, Krumpe] Univ Massachusetts, Sch Med, Dept Med, Div Hematol Oncol, Worcester, MA USA. [Chonghaile, Triona; Letai, Anthony G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Walters, Stephanie; Lyle, Stephen] Univ Massachusetts, Sch Med, Dept Canc Biol & Pathol, Worcester, MA USA. RI Ni Chonghaile, Triona/L-9418-2015 OI Ni Chonghaile, Triona/0000-0002-3041-4031 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1690 EP 1690 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106121 ER PT J AU Cao, Y Hunter, Z Zhou, YS Liu, X Yang, G Xu, L Patterson, C Treon, SP AF Cao, Yang Hunter, Zachary Zhou, Yangsheng Liu, Xia Yang, Guang Xu, Lian Patterson, Christopher Treon, Steven P. TI MicroRNA-21 and-155 Are Induced by a Widely Expressed Mutation in MyD88 (L265P) in Waldenstrom's Macroglobulinemia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Cao, Yang; Hunter, Zachary; Zhou, Yangsheng; Liu, Xia; Yang, Guang; Xu, Lian; Patterson, Christopher] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA. [Treon, Steven P.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. RI Hunter, Zachary/H-3018-2013 OI Hunter, Zachary/0000-0002-1689-1691 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1692 EP 1692 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106126 ER PT J AU Bellucci, R Martin, A Buren, M Nguyen, HN Bommarito, D Ritz, J AF Bellucci, Roberto Martin, Allison Buren, Marc Hong-Nam Nguyen Bommarito, Davide Ritz, Jerome TI JAK1 and JAK2 Modulate Myeloma Cell Susceptibility to NK Cells Through the Interferon Gamma (IFN-gamma) Pathway SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Bellucci, Roberto] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1694 EP 1694 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106129 ER PT J AU Munshi, NC Lee, S Kambhampati, S Rose, M Mohiuddin, A Efebera, Y Han, A Houranieh, A Zimelman, A Brophy, MT Prabhala, R Grady, T Mehta, P Hayes, TG Yellapragada, SV Behler, C Klein, C Roodman, D Lichtenstein, AK AF Munshi, Nikhil C. Lee, Saem Kambhampati, Suman Rose, Michal Mohiuddin, Abid Efebera, Yvonne Han, Andrew Houranieh, Antoun Zimelman, Abraham Brophy, Mary T. Prabhala, Rao Grady, Terrence Mehta, Paulette Hayes, Teresa G. Yellapragada, Sarvari Venkata Behler, Caroline Klein, Catherine Roodman, David Lichtenstein, Alan K. TI Once a Week Bortezomib with Dexamethasone Is Effective with Limited Toxicity in Newly Diagnosed Multiple Myeloma Patients with Older Age and Co-Morbidities SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Munshi, Nikhil C.; Lee, Saem; Efebera, Yvonne; Han, Andrew; Houranieh, Antoun; Zimelman, Abraham; Brophy, Mary T.; Prabhala, Rao] VA Boston Healthcare Syst, Boston, MA USA. [Kambhampati, Suman] Kansas City VA Med Ctr, Kansas City, MO USA. [Rose, Michal] VA Connecticut Healthcare Syst, West Haven, CT USA. [Mohiuddin, Abid] Atlanta VA Med Ctr, Atlanta, GA USA. [Grady, Terrence] James A Haley Vet Hosp, Tampa, FL 33612 USA. [Mehta, Paulette] John L McClellan Mem Vet Adm Med Ctr, Little Rock, AR USA. [Hayes, Teresa G.; Yellapragada, Sarvari Venkata] Michael E DeBakey VA Med Ctr, Houston, TX USA. [Behler, Caroline] San Francisco VA Med Ctr, San Francisco, CA USA. [Klein, Catherine] VA Eastern Colorado Hlth Care Syst, Denver, CO USA. [Roodman, David] Univ Pittsburgh, Sch Med, Dept Med, Div Hematol Oncol, Pittsburgh, PA USA. [Roodman, David] Inst Canc Res, Pittsburgh, PA USA. [Lichtenstein, Alan K.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. RI Efebera, Yvonne/E-3012-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1695 EP 1696 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106133 ER PT J AU Yee, AJ Mahindra, AK Richardson, PG Cirstea, DD Scullen, TA Rodig, SJ Hideshima, T Hari, P Laubach, JP Ghobrial, IM Schlossman, R Munshi, NC Weller, EA Anderson, KC Raje, NS AF Yee, Andrew J. Mahindra, Anuj K. Richardson, Paul G. Cirstea, Diana D. Scullen, Tyler A. Rodig, Scott J. Hideshima, Teru Hari, Parameswaran Laubach, Jacob P. Ghobrial, Irene M. Schlossman, Robert Munshi, Nikhil C. Weller, Edie A. Anderson, Kenneth C. Raje, Noopur S. TI Biomarker Correlation with Outcomes in Patients with Relapsed or Refractory Multiple Myeloma on a Phase I Study of Everolimus in Combination with Lenalidomide SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Yee, Andrew J.; Mahindra, Anuj K.; Cirstea, Diana D.; Scullen, Tyler A.; Raje, Noopur S.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Richardson, Paul G.; Hideshima, Teru; Laubach, Jacob P.; Ghobrial, Irene M.; Schlossman, Robert; Munshi, Nikhil C.; Weller, Edie A.; Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Rodig, Scott J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Hari, Parameswaran] Med Coll Wisconsin, Milwaukee, WI 53226 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1696 EP 1697 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106135 ER PT J AU Jagannath, S Lonial, S Jakubowiak, AJ Facon, T Vij, R Raab, MS White, DJ Wang, MH Parli, T Bartlett, BJ Singhal, AK Richardson, PG AF Jagannath, Sundar Lonial, Sagar Jakubowiak, Andrzej J. Facon, Thierry Vij, Ravi Raab, Marc S. White, Darrell J. Wang, Min-Hui Parli, Teresa Bartlett, Blake J. Singhal, Anil K. Richardson, Paul G. TI Elotuzumab in Combination with Lenalidomide and Low-Dose Dexamethasone in High-Risk and/or Stage 2-3 Relapsed and/or Refractory Multiple Myeloma: A Retrospective Subset Analysis of the Phase 2 Study SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Jagannath, Sundar] Mt Sinai Hosp, New York, NY 10029 USA. [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. [Jakubowiak, Andrzej J.] Univ Michigan, Ann Arbor, MI 48109 USA. [Facon, Thierry] CHRU Lille, Hop Huriez, Serv Malad Sang, Lille, France. [Vij, Ravi] Washington Univ, Sch Med, Div Oncol, St Louis, MO USA. [Raab, Marc S.] Univ Klinikum Heildelberg, Heidelberg, Germany. [White, Darrell J.] Queen Elizabeth 2 Hlth Sci Ctr, Div Hematol, Halifax, NS, Canada. [Wang, Min-Hui; Parli, Teresa; Singhal, Anil K.] Abbott Biotherapeut, Redwood City, CA USA. [Bartlett, Blake J.] Bristol Myers Squibb Co, Princeton, NJ USA. [Richardson, Paul G.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. RI FACON, THIERRY/M-9736-2014 OI FACON, THIERRY/0000-0001-7705-8460 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1697 EP 1698 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106137 ER PT J AU San-Miguel, JF Hungria, VTD Yoon, SS Wiktor-Jedrzejczak, W Elghandour, A Siritanaratkul, N Dimopoulos, MA Corradini, P Nakorn, TN Shelekhova, T Gunther, A Yong, K Schlossman, R Wroclawska-Swacha, M Weber, HJ Bourquelot, P Hou, J Einsele, H Lee, JH Moreau, P Lonial, S Richardson, PG AF San-Miguel, Jesus F. de Moraes Hungria, Vania Tietsche Yoon, Sung-Soo Wiktor-Jedrzejczak, Wieslaw Elghandour, Ashraf Siritanaratkul, Noppadol Dimopoulos, Meletios Athanasios Corradini, Paolo Nakorn, Thanyaphong Na Shelekhova, Tatiana Guenther, Andreas Yong, Kwee Schlossman, Robert Wroclawska-Swacha, Monika Weber, Hans-Jochen Bourquelot, Priscille Hou, Jian Einsele, Hermann Lee, Jae Hoon Moreau, Philippe Lonial, Sagar Richardson, Paul G. TI Update on a Phase III Study of Panobinostat with Bortezomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: PANORAMA 1 SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [San-Miguel, Jesus F.] Hosp Univ Salamanca, Salamanca, Spain. [de Moraes Hungria, Vania Tietsche] Santa Casa Sao Paulo, Sao Paulo, Brazil. [Yoon, Sung-Soo] Seoul Natl Univ Hosp, Seoul 110744, South Korea. [Wiktor-Jedrzejczak, Wieslaw] Med Univ Warsaw, Warsaw, Poland. [Elghandour, Ashraf] Univ Alexandria, Alexandria, Egypt. [Siritanaratkul, Noppadol] Siriraj Hosp, Bangkok, Thailand. [Dimopoulos, Meletios Athanasios] Univ Athens, Sch Med, Dept Clin Therapeut, GR-11527 Athens, Greece. [Corradini, Paolo] Univ Milan, Ist Nazl Tumori, Div Hematol, Milan, Italy. [Nakorn, Thanyaphong Na] Chulalongkorn Univ, Bangkok, Thailand. [Shelekhova, Tatiana] Saratov State Med Univ, Clin Profess Pathol & Hematol, Saratov, Russia. [Guenther, Andreas] Univ Kiel, Dept Med 2, Div Stem Cell Transplantat & Immunotherapy, Kiel, Germany. [Yong, Kwee] UCL Canc Inst, London, England. [Schlossman, Robert; Richardson, Paul G.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Wroclawska-Swacha, Monika; Weber, Hans-Jochen; Bourquelot, Priscille] Novartis Pharma AG, Basel, Switzerland. [Hou, Jian] Chang Zheng Hosp, Shanghai, Peoples R China. [Einsele, Hermann] Univ Hosp Wurzburg, Wurzburg, Germany. [Lee, Jae Hoon] Gachon Univ, Gil Hosp, Inchon, South Korea. [Moreau, Philippe] Univ Hosp Nantes, Nantes, France. [Lonial, Sagar] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. RI Hungria, Vania/G-3141-2012; richard, chrystelle/K-8595-2015 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1701 EP 1702 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106145 ER PT J AU Kumar, S Lee, JH Lahuerta, JJ Morgan, GJ Richardson, PG Crowley, J Haessler, J Feather, J Hoering, A Moreau, P Leleu, X Hullin, C Klein, SK Sonneveld, P Siegel, DS Blade, J Goldschmidt, H Jagannath, S San Miguel, JF Orlowski, RZ Palumbo, A Sezer, O Rajkumar, SV Durie, BGM AF Kumar, Shaji Lee, Jae Hoon Jose Lahuerta, Juan Morgan, Gareth J. Richardson, Paul G. Crowley, John Haessler, Jeff Feather, John Hoering, Antje Moreau, Philippe Leleu, Xavier Hullin, Cyril Klein, Saskia K. Sonneveld, Pieter Siegel, David S. Blade, Joan Goldschmidt, Hartmut Jagannath, Sundar San Miguel, Jesus F. Orlowski, Robert Z. Palumbo, Antonio Sezer, Orhan Rajkumar, S. Vincent Durie, Brian G. M. TI Differences in Patterns of Treatment and Outcome Among Patients with Relapsed Refractory Myeloma From United States, Europe and Asia SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Lee, Jae Hoon] Gachon Univ, Gil Hosp, Inchon, South Korea. [Jose Lahuerta, Juan] Hosp Univ 12 Octubre, Madrid, Spain. [Morgan, Gareth J.] Inst Canc Res, Div Mol Pathol, London SW3 6JB, England. [Richardson, Paul G.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA. [Crowley, John; Haessler, Jeff; Hoering, Antje] Canc Res & Biostat, Res & Biostat, Seattle, WA USA. [Moreau, Philippe] Univ Hosp Nantes, Dept Hematol, Nantes, France. [Leleu, Xavier] CHRU, Hop Huriez, Lille, France. [Hullin, Cyril] Hop Brabois, Nancy, France. [Klein, Saskia K.] Eramus, Hematol, Rotterdam, Netherlands. [Sonneveld, Pieter] Erasmus Univ, Med Ctr, Dept Hematol, Rotterdam, Netherlands. [Siegel, David S.] Hackensack Univ, Med Ctr, John Theurer Canc Ctr, Hackensack, NJ USA. [Blade, Joan] Hosp Clin Barcelona, Barcelona, Spain. [Goldschmidt, Hartmut] Univ Heidelberg, Dept Internal Med 5, Heidelberg, Germany. [Goldschmidt, Hartmut] Natl Ctr Tumor Dis NCT, Heidelberg, Germany. [Jagannath, Sundar] Mt Sinai Canc Inst, New York, NY USA. [San Miguel, Jesus F.] Hosp Univ Salamanca, Ctr Invest, Salamanca, Spain. [Orlowski, Robert Z.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Palumbo, Antonio] Univ Turin, Myeloma Unit, Div Hematol, AOU S Giovanni Battista, Turin, Italy. [Sezer, Orhan] Univ Hamburg, Med Ctr, Dep Hematol Oncol & Stem Cell Transplantat, Hamburg, Germany. [Rajkumar, S. Vincent] Mayo Clin, Div Hematol, Dept Internal Med, Rochester, MN USA. [Durie, Brian G. M.] Aptium Oncol Inc, Rsch Network, Los Angeles, CA USA. RI Kumar, Shaji/A-9853-2008; richard, chrystelle/K-8595-2015 OI Kumar, Shaji/0000-0001-5392-9284; NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1707 EP 1708 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106158 ER PT J AU Bae, J Carrasco, R Lee, AH Prabhala, R Tai, YT Song, WH Anderson, KC Munshi, NC AF Bae, Jooeun Carrasco, Ruben Lee, Ann-Hwee Prabhala, Rao Tai, Yu-Tzu Song, Weihua Anderson, Kenneth C. Munshi, Nikhil C. TI Novel Myeloma-Specific Multiple Peptides Able to Generate Cytotoxic T Lymphocytes: Potential Therapeutic Application in Multiple Myeloma and Other Plasma Cell Disorders SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Anderson, Kenneth C.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Lee, Ann-Hwee] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. [Prabhala, Rao] VA Boston Healthcare Syst, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1708 EP 1708 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106159 ER PT J AU Glotzbecker, B Ho, VT Aldridge, J Kim, HT Horowitz, G Ritz, J Soiffer, RJ Avigan, D Rosenblatt, J AF Glotzbecker, Brett Ho, Vincent T. Aldridge, Julie Kim, Haesook T. Horowitz, Gary Ritz, Jerome Soiffer, Robert J. Avigan, David Rosenblatt, Jacalyn TI Low Levels of 25-Hydroxyvitamin D Prior to Allogeneic Transplantation Correlate with the Development of Chronic Graft-Versus-Host Disease SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Glotzbecker, Brett; Horowitz, Gary; Avigan, David; Rosenblatt, Jacalyn] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Ho, Vincent T.; Aldridge, Julie; Kim, Haesook T.; Ritz, Jerome; Soiffer, Robert J.] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1735 EP 1735 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106232 ER PT J AU Glotzbecker, B Mills, H Rosenblatt, J Joyce, R Levine, J Tzachanis, D Stevenson, M Attar, EC Ballen, KK Chen, YBA Boussiotis, VA Zwicker, J Luptakova, K Arnason, JE Bonhoff, J Delaney, C Conway, K Giallombardo, N Mortellite, J Glass, J Fitzgerald, D O'Brien, S McMahon, C Vasir, B Stroopinsky, D Spitzer, TR Avigan, D AF Glotzbecker, Brett Mills, Heidi Rosenblatt, Jacalyn Joyce, Robin Levine, James Tzachanis, Dimitrios Stevenson, Maryann Attar, Eyal C. Ballen, Karen K. Chen, Yi-Bin A. Boussiotis, Vassiliki A. Zwicker, Jeffrey Luptakova, Katarina Arnason, Jon E. Bonhoff, Jessica Delaney, Carol Conway, Katharine Giallombardo, Nancy Mortellite, Jamie Glass, Jason Fitzgerald, Donna O'Brien, Stefanie McMahon, Caitlin Vasir, Baldev Stroopinsky, Dina Spitzer, Thomas R. Avigan, David TI Addition of Clofarabine to TLI/ATG Conditioning: Impact on Immune Reconstitution and Clinical Outcomes SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Glotzbecker, Brett; Mills, Heidi; Rosenblatt, Jacalyn; Joyce, Robin; Levine, James; Tzachanis, Dimitrios; Stevenson, Maryann; Boussiotis, Vassiliki A.; Zwicker, Jeffrey; Luptakova, Katarina; Arnason, Jon E.; Bonhoff, Jessica; Delaney, Carol; Conway, Katharine; Giallombardo, Nancy; Mortellite, Jamie; Glass, Jason; Fitzgerald, Donna; O'Brien, Stefanie; McMahon, Caitlin; Stroopinsky, Dina; Avigan, David] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Attar, Eyal C.; Ballen, Karen K.; Chen, Yi-Bin A.; Spitzer, Thomas R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Vasir, Baldev] Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1736 EP 1737 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106235 ER PT J AU Brown, J Kim, HT Cutler, C McDonough, S Alyea, E Ho, V Attar, EC Dey, BR McAfee, SL Spitzer, T Soiffer, RJ Ritz, J Antin, JH Ballen, KK Boussiotis, VA AF Brown, Julia Kim, Haesook T. Cutler, Corey McDonough, Sean Alyea, Edwin Ho, Vincent Attar, Eyal C. Dey, Bimalangshu R. McAfee, Steven L. Spitzer, Thomas Soiffer, Robert J. Ritz, Jerome Antin, Joseph H. Ballen, Karen K. Boussiotis, Vassiliki A. TI Immune Reconstitution After Cord Blood Transplantation in Adults Depends on Activity of Thymic Epithelial Cells and Vascular Endothelial Elements SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Brown, Julia; Boussiotis, Vassiliki A.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. [Cutler, Corey; McDonough, Sean; Alyea, Edwin; Ho, Vincent; Soiffer, Robert J.; Antin, Joseph H.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Attar, Eyal C.; Dey, Bimalangshu R.; McAfee, Steven L.; Spitzer, Thomas; Ballen, Karen K.] Massachusetts Gen Hosp, Bone Marrow Transplant Unit, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1740 EP 1740 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106244 ER PT J AU Evens, AM Vanderplas, A LaCasce, A Crosby, A Nademanee, A Kaminski, MS Abel, GA Millenson, M Czuczman, MS Rodriguez, MA Niland, J Zelenetz, AD Gordon, LI Friedberg, J AF Evens, Andrew M. Vanderplas, Ann LaCasce, Ann Crosby, Allison Nademanee, Auayporn Kaminski, Mark S. Abel, Gregory A. Millenson, Michael Czuczman, Myron S. Rodriguez, Maria A. Niland, Joyce Zelenetz, Andrew D. Gordon, Leo I. Friedberg, Jonathan TI Outcomes with Autologous (Auto) and Allogeneic (Allo) Stem Cell Transplantation (SCT) for Relapsed/Refractory Follicular Lymphoma (FL) in the Post-Rituximab Era: A Comparative Analysis From the National Comprehensive Cancer Network (NCCN) Non-Hodgkin's Lymphoma (NHL) Outcomes Database Project SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Evens, Andrew M.] Univ Massachusetts, Sch Med, Div Hematol Oncol, Worcester, MA USA. [Niland, Joyce] City Hope Natl Med Ctr, Data Coordinating Ctr, Duarte, CA 91010 USA. [LaCasce, Ann] Dana Farber Canc Inst, Dept Med Onc, Boston, MA 02115 USA. [Crosby, Allison] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Nademanee, Auayporn] City Hope Natl Med Ctr, Hematol & Stem Cell Transplantat, Duarte, CA USA. [Kaminski, Mark S.] Univ Michigan, Ann Arbor, MI 48109 USA. [Millenson, Michael] Fox Chase Canc Ctr, Boston, MA USA. [Czuczman, Myron S.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Rodriguez, Maria A.] UT MD Anderson Canc Ctr, Houston, TX USA. [Zelenetz, Andrew D.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Gordon, Leo I.] Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA. [Gordon, Leo I.] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA. [Friedberg, Jonathan] Univ Rochester, James P Wilmot Canc Ctr, Rochester, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1756 EP 1757 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106280 ER PT J AU Luskin, MR Campigotto, F Richardson, PG Koreth, J Ghobrial, IM Schlossman, R Soiffer, RJ Munshi, NC Warren, D Gannon, M Finn, K Anderson, KC Weller, E Laubach, JP AF Luskin, Marlise R. Campigotto, Federico Richardson, Paul G. Koreth, John Ghobrial, Irene M. Schlossman, Robert Soiffer, Robert J. Munshi, Nikhil C. Warren, Diane Gannon, Muriel Finn, Kathleen Anderson, Kenneth C. Weller, Edie Laubach, Jacob P. TI RVD Induction Followed by Consolidation with ASCT in Patients with Newly Diagnosed Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Luskin, Marlise R.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Campigotto, Federico; Weller, Edie] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Richardson, Paul G.; Koreth, John; Ghobrial, Irene M.; Schlossman, Robert; Soiffer, Robert J.; Munshi, Nikhil C.; Warren, Diane; Gannon, Muriel; Finn, Kathleen; Anderson, Kenneth C.; Laubach, Jacob P.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1767 EP 1768 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106301 ER PT J AU Dai, LJ O'Sullivan, A Kennedy, R Abbas, M Shuai, YL Passero, VA Andreas, C Gardner, D Redner, RL Roodman, GD Marks, SM Raptis, A Hou, JZ Petro, D Sun, M Evans, T Pietragallo, LV Waas, JK Viverette, JF Osborn, J Reyes, V Pinkerton, R Crandall, T Fierro, R Volkin, R Normolle, D Mapara, MY Lentzsch, S AF Dai, Lijun O'Sullivan, Amy Kennedy, Ryan Abbas, Mohammad Shuai, Yongli Passero, Vida Almario Andreas, Carrie Gardner, Diane Redner, Robert L. Roodman, G. David Marks, Stanley M. Raptis, Anastasios Hou, Jing-Zhou Petro, Daniel Sun, Min Evans, Terry Pietragallo, Louis V. Waas, John K. Viverette, J. Franklin Osborn, Jennifer Reyes, Vincent Pinkerton, Richard Crandall, Theodore Fierro, Ronald Volkin, Robert Normolle, Daniel Mapara, Markus Y. Lentzsch, Suzanne TI A Randomized Clinical Trial of Lenalidomide and Dexamethasone with and without Autologous Stem Cell Transplant in Patients with Newly Diagnosed Multiple Myeloma: Interim Study Results SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Dai, Lijun; O'Sullivan, Amy; Kennedy, Ryan; Abbas, Mohammad; Passero, Vida Almario; Andreas, Carrie; Gardner, Diane; Redner, Robert L.; Mapara, Markus Y.; Lentzsch, Suzanne] Univ Pittsburgh, Sch Med, Dept Med, Div Hematol Oncol, Pittsburgh, PA USA. [Dai, Lijun; O'Sullivan, Amy; Kennedy, Ryan; Abbas, Mohammad; Passero, Vida Almario; Andreas, Carrie; Gardner, Diane; Redner, Robert L.; Mapara, Markus Y.; Lentzsch, Suzanne] Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA. [Shuai, Yongli; Normolle, Daniel] Univ Pittsburgh, Inst Canc, Biostat Facil, Pittsburgh, PA USA. [Roodman, G. David] VA Pittsburgh Healthcare Syst, Med Hem Onc, Pittsburgh, PA USA. [Marks, Stanley M.; Raptis, Anastasios; Hou, Jing-Zhou; Petro, Daniel; Sun, Min; Pietragallo, Louis V.; Osborn, Jennifer; Reyes, Vincent; Volkin, Robert] UPMC Canc Ctr, Pittsburgh, PA USA. [Evans, Terry; Waas, John K.; Viverette, J. Franklin] UPMC Canc Ctr, Greensburg, PA USA. [Pinkerton, Richard] UPMC Canc Ctr, Indiana, PA USA. [Crandall, Theodore] UPMC Canc Ctr, Wexford, PA USA. [Fierro, Ronald] UPMC Canc Ctr, Clairton, PA USA. RI mapara, markus/A-2134-2013; pinkerton, ross/I-4808-2014 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1771 EP 1772 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597106309 ER PT J AU Garfall, AL Kim, HT Sun, LX Ho, VT Armand, P Koreth, J Alyea, E Soiffer, RJ Antin, JH Ritz, J Cutler, CS AF Garfall, Alfred L. Kim, Haesook T. Sun, Lixian Ho, Vincent T. Armand, Philippe Koreth, John Alyea, Edwin Soiffer, Robert J. Antin, Joseph H. Ritz, Jerome Cutler, Corey S. TI KIR-Ligand Incompatibility Is Not Associated with Relapse Reduction After Double Umbilical Cord Blood Transplantation SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Garfall, Alfred L.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Kim, Haesook T.] Dana Farber Canc Inst, Dept Biostat & Computat, Boston, MA 02115 USA. [Ho, Vincent T.; Koreth, John; Alyea, Edwin; Antin, Joseph H.; Cutler, Corey S.] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA. [Armand, Philippe] Dana Farber Brigham & Womens Canc Ctr, Div Hematol Malignancies, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1775 EP 1775 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106317 ER PT J AU Dranoff, G AF Dranoff, Glenn TI The Interplay of Inflammation and Cancer SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Dranoff, Glenn] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1809 EP 1809 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597106394 ER PT J AU Lee-Huang, S Huang, PL Huang, PL AF Lee-Huang, Sylvia Huang, Philip Lin Huang, Paul Lee TI Live-cell real-time imaging reveals role of mitochondria in cell-to-cell transmission of HIV-1 SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE HIV-1; Live-cell real-time imaging; Viral transmission; Mitochondria ID HUMAN-IMMUNODEFICIENCY-VIRUS; VIROLOGICAL SYNAPSES; INFECTION; SPREAD; FUSION; CD4 AB We used live-cell, real-time fluorescence imaging of co-cultures of HIV-1 infected T cells and uninfected target cells to examine the action of mitochondria during cell-to-cell transmission of the virus. We find that mitochondria of HIV infected cells enter uninfected target cells and advance viral spread. We show that human mitochondria serve as viral reservoirs and carriers and that they can move between cells. This was confirmed by our results that purified mitochondria from HIV infected cells are infectious, and that mitochondrial inhibitors block HIV transmission. Viral infection and replication in the target cells were verified by syncytial formation and HIV-1 core protein p24 production. Our results offer new insights into the cellular mechanisms of viral transmission and identify mitochondria as new host targets for viral infection. (C) 2011 Elsevier Inc. All rights reserved. C1 [Lee-Huang, Sylvia; Huang, Philip Lin] NYU, Sch Med, Dept Biochem, New York, NY 10016 USA. [Huang, Paul Lee] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Huang, Paul Lee] Harvard Univ, Sch Med, Boston, MA 02114 USA. RP Lee-Huang, S (reprint author), NYU, Sch Med, Dept Biochem, New York, NY 10016 USA. EM sylvia.lee-huang@med.nyu.edu OI Lee-Huang, Sylvia/0000-0003-3302-241X NR 16 TC 3 Z9 3 U1 0 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD NOV 18 PY 2011 VL 415 IS 2 BP 384 EP 389 DI 10.1016/j.bbrc.2011.10.078 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 855AB UT WOS:000297534800031 PM 22037455 ER PT J AU Armache, KJ Garlick, JD Canzio, D Narlikar, GJ Kingston, RE AF Armache, Karim-Jean Garlick, Joseph D. Canzio, Daniele Narlikar, Geeta J. Kingston, Robert E. TI Structural Basis of Silencing: Sir3 BAH Domain in Complex with a Nucleosome at 3.0 angstrom Resolution SO SCIENCE LA English DT Article ID SACCHAROMYCES-CEREVISIAE; HISTONE H3; MATING LOCI; TELOMERIC HETEROCHROMATIN; PROTEIN INTERACTIONS; GENETIC-ANALYSIS; CORE PARTICLE; N-TERMINUS; YEAST; CHROMATIN AB Gene silencing is essential for regulating cell fate in eukaryotes. Altered chromatin architectures contribute to maintaining the silenced state in a variety of species. The silent information regulator (Sir) proteins regulate mating type in Saccharomyces cerevisiae. One of these proteins, Sir3, interacts directly with the nucleosome to help generate silenced domains. We determined the crystal structure of a complex of the yeast Sir3 BAH (bromo-associated homology) domain and the nucleosome core particle at 3.0 angstrom resolution. We see multiple molecular interactions between the protein surfaces of the nucleosome and the BAH domain that explain numerous genetic mutations. These interactions are accompanied by structural rearrangements in both the nucleosome and the BAH domain. The structure explains how covalent modifications on H4K16 and H3K79 regulate formation of a silencing complex that contains the nucleosome as a central component. C1 [Armache, Karim-Jean; Garlick, Joseph D.; Kingston, Robert E.] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. [Armache, Karim-Jean; Garlick, Joseph D.; Kingston, Robert E.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [Canzio, Daniele; Narlikar, Geeta J.] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA. [Canzio, Daniele] Univ Calif San Francisco, Chem & Chem Biol Grad Program, San Francisco, CA 94158 USA. RP Kingston, RE (reprint author), Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. EM kingston@molbio.mgh.harvard.edu FU NIH [GM043901]; Human Frontier Science Program FX This work was supported by grant GM043901 from NIH (to R. E. K.). K-J.A. was supported in part by a fellowship from the Human Frontier Science Program. We thank the staff at Beamlines 24-IDC/E at Argonne National Laboratory, especially K. Rajashankar and F. Murphy, for excellent assistance with data collection. We thank R. Sternglanz for BAH domain constructs. We thank T. Schwartz for use of the high-throughput crystallization facility, as well as helpful discussions and critical reading of the manuscript. We thank F. Winston for critical reading of the manuscript. We thank S. Jenni and D. Kostrewa for helpful discussions; S. Tan and K. Luger for help with technical aspects of forming nucleosomes; J. Cochrane, S. Bowman, S. Miller, M. Simon, and K. Bouazoune for critical reading of the manuscript, and members of the Kingston laboratory for helpful discussions. Coordinates and structure factors have been deposited in the Protein Data Bank with accession code 3TU4. NR 52 TC 94 Z9 94 U1 2 U2 15 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD NOV 18 PY 2011 VL 334 IS 6058 BP 977 EP 982 DI 10.1126/science.1210915 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 849CA UT WOS:000297101800056 PM 22096199 ER PT J AU Xu, J Peng, C Sankaran, VG Shao, Z Esrick, EB Chong, BG Ippolito, GC Fujiwara, Y Ebert, BL Tucker, PW Orkin, SH AF Xu, Jian Peng, Cong Sankaran, Vijay G. Shao, Zhen Esrick, Erica B. Chong, Bryan G. Ippolito, Gregory C. Fujiwara, Yuko Ebert, Benjamin L. Tucker, Philip W. Orkin, Stuart H. TI Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing SO SCIENCE LA English DT Article ID MOUSE MODEL; GAMMA-GLOBIN; BCL11A; BETA; HAEMOGLOBIN; THALASSEMIA; FAMILIES; THERAPY AB Persistence of human fetal hemoglobin (HbF, alpha(2)gamma(2)) in adults lessens the severity of sickle cell disease (SCD) and the beta-thalassemias. Here, we show that the repressor BCL11A is required in vivo for silencing of gamma-globin expression in adult animals, yet dispensable for red cell production. BCL11A serves as a barrier to HbF reactivation by known HbF inducing agents. In a proof-of-principle test of BCL11A as a potential therapeutic target, we demonstrate that inactivation of BCL11A in SCD transgenic mice corrects the hematologic and pathologic defects associated with SCD through high-level pancellular HbF induction. Thus, interference with HbF silencing by manipulation of a single target protein is sufficient to reverse SCD. C1 [Xu, Jian; Peng, Cong; Sankaran, Vijay G.; Shao, Zhen; Esrick, Erica B.; Chong, Bryan G.; Fujiwara, Yuko; Orkin, Stuart H.] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA. [Xu, Jian; Peng, Cong; Sankaran, Vijay G.; Shao, Zhen; Esrick, Erica B.; Chong, Bryan G.; Fujiwara, Yuko; Orkin, Stuart H.] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Xu, Jian; Peng, Cong; Sankaran, Vijay G.; Shao, Zhen; Esrick, Erica B.; Chong, Bryan G.; Fujiwara, Yuko; Orkin, Stuart H.] Harvard Univ, Sch Med, Harvard Stem Cell Inst, Boston, MA 02115 USA. [Xu, Jian; Fujiwara, Yuko; Orkin, Stuart H.] Howard Hughes Med Inst, Boston, MA 02115 USA. [Esrick, Erica B.; Ebert, Benjamin L.] Harvard Univ, Dana Farber Canc Inst, Brigham & Womens Hosp, Harvard Stem Cell Inst,Med Sch, Boston, MA 02115 USA. [Ippolito, Gregory C.; Tucker, Philip W.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Sankaran, Vijay G.] Broad Inst, Cambridge, MA 02142 USA. [Sankaran, Vijay G.] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. RP Orkin, SH (reprint author), Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA. EM stuart_orkin@dfci.harvard.edu RI Peng, Cong/H-2286-2011 FU NIH; National Cancer Institute (NCI); Marie Betzner Morrow Endowment; National Institute of Diabetes and Digestive and Kidney Diseases; National Research Service Award/NCI FX We thank K. Peterson and H. Fedosyuk for beta-locus mice, K. Gaensler and M. Groudine for the A20 strain of beta-locus mice, T. M. Townes for the SCD mice, and M. Nguyen, R. Okabe, and J. Alves for technical assistance. We thank D. Higgs, D. A. Williams, L. I. Zon, D. E. Bauer, H. F. Xie, M. Kerenyi, T. Menne, J. Harriss, and J. Decker for advice and discussions. This work was supported by funding from NIH (S.H.O. and B. L. E.); the National Cancer Institute (NCI) and the Marie Betzner Morrow Endowment (P. W. T.); and a Center Award from the National Institute of Diabetes and Digestive and Kidney Diseases (S.H.O.). G. C. I. was supported by a National Research Service Award/NCI postdoctoral fellowship, and J. X. is a Howard Hughes Medical Institute-Helen Hay Whitney Foundation fellow. The authors declare no conflict of interest. NR 29 TC 117 Z9 118 U1 6 U2 23 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD NOV 18 PY 2011 VL 334 IS 6058 BP 993 EP 996 DI 10.1126/science.1211053 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 849CA UT WOS:000297101800060 PM 21998251 ER PT J AU Cohen, NR Tatituri, RVV Rivera, A Watts, GFM Kim, EY Chiba, A Fuchs, BB Mylonakis, E Besra, GS Levitz, SM Brigl, M Brenner, MB AF Cohen, Nadia R. Tatituri, Raju V. V. Rivera, Amariliz Watts, Gerald F. M. Kim, Edy Y. Chiba, Asako Fuchs, Beth B. Mylonakis, Eleftherios Besra, Gurdyal S. Levitz, Stuart M. Brigl, Manfred Brenner, Michael B. TI Innate Recognition of Cell Wall beta-Glucans Drives Invariant Natural Killer T Cell Responses against Fungi SO CELL HOST & MICROBE LA English DT Article ID NKT CELLS; ASPERGILLUS-FUMIGATUS; ALPHA-GALACTOSYLCERAMIDE; IMMUNE-RESPONSE; CRYPTOCOCCUS-NEOFORMANS; DENDRITIC CELLS; TH1 RESPONSE; MICROBIAL INFECTION; VIRUS-INFECTION; HOST-DEFENSE AB iNKT cells are innate T lymphocytes recognizing endogenous and foreign lipid antigens presented in the MHC-like molecule CD1d. The semi-invariant iNKT cell TCR can detect certain bacterial and parasitic lipids and drive iNKT cell responses. How iNKT cells respond to fungi, however, is unknown. We found that CD1d-deficient mice, which lack iNKT cells, poorly control infection with the fungal pathogen Aspergillus fumigatus. Furthermore, A. fumigatus rapidly activates iNKT cells in vivo and in vitro in the presence of APCs. Surprisingly, despite a requirement for CD1d recognition, the antifungal iNKT cell response does not require fungal lipids. Instead, Dectin-1- and MyD88-mediated responses to beta-1,3 glucans, major fungal cell-wall polysaccharides, trigger IL-12 production by APCs that drives self-reactive iNKT cells to secrete IFN-gamma. Innate recognition of beta-1,3 glucans also drives iNKT cell responses against Candida, Histoplasma, and Alternaria, suggesting that this mechanism may broadly define the basis for antifungal iNKT cell responses. C1 [Cohen, Nadia R.; Tatituri, Raju V. V.; Watts, Gerald F. M.; Kim, Edy Y.; Chiba, Asako; Brigl, Manfred; Brenner, Michael B.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA. [Brigl, Manfred] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA. [Rivera, Amariliz] Univ Med & Dent New Jersey, New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ 07101 USA. [Fuchs, Beth B.; Mylonakis, Eleftherios] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Besra, Gurdyal S.] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England. [Levitz, Stuart M.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA. RP Cohen, NR (reprint author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA. EM nadia_cohen@hms.harvard.edu; mbrigl@partners.org; mbrenner@rics.bwh.harvard.edu FU NIH [AI063428-06A1, K08AI077795]; Department of Energy [DE-FG09-93ER-20097]; Sandler Foundation [06-0058] FX We thank the National Institutes of Health (NIH) for providing CD1d tetramers; G. Ostroff for help with polysaccharide purification and analysis and for providing reagents; G. Deepe and C. Steele for H.c. samples; H. Kita for A.a isolates; and D. Perlin, Y. Zhao, A. Tuli, M.W. Painter, H. Kim, D. Moody, S. Turley, N. Letvin, J. Cohen, and E. Pamer for their critical input or technical help. This work was supported by the NIH (grant AI063428-06A1, M.B.B.; K08AI077795, M.B.), the Department of Energy-funded (DE-FG09-93ER-20097) Center for Plant and Microbial Complex Carbohydrates, and the Sandler Foundation (grant 06-0058, M.B.B.). NR 67 TC 49 Z9 50 U1 0 U2 5 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 J9 CELL HOST MICROBE JI Cell Host Microbe PD NOV 17 PY 2011 VL 10 IS 5 BP 437 EP 450 DI 10.1016/j.chom.2011.09.011 PG 14 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 854LD UT WOS:000297495100004 PM 22100160 ER PT J AU Lahar, N Lei, NY Wang, JF Jabaji, Z Tung, SC Joshi, V Lewis, M Stelzner, M Martin, MG Dunn, JCY AF Lahar, Nicholas Lei, Nan Ye Wang, Jiafang Jabaji, Ziyad Tung, Stephaine C. Joshi, Vaidehi Lewis, Michael Stelzner, Matthias Martin, Martin G. Dunn, James C. Y. TI Intestinal Subepithelial Myofibroblasts Support in vitro and in vivo Growth of Human Small Intestinal Epithelium SO PLOS ONE LA English DT Article ID STEM-CELLS; DIFFERENTIATION; RENEWAL; NICHE AB The intestinal crypt-niche interaction is thought to be essential to the function, maintenance, and proliferation of progenitor stem cells found at the bases of intestinal crypts. These stem cells are constantly renewing the intestinal epithelium by sending differentiated cells from the base of the crypts of Lieberkuhn to the villus tips where they slough off into the intestinal lumen. The intestinal niche consists of various cell types, extracellular matrix, and growth factors and surrounds the intestinal progenitor cells. There have recently been advances in the understanding of the interactions that regulate the behavior of the intestinal epithelium and there is great interest in methods for isolating and expanding viable intestinal epithelium. However, there is no method to maintain primary human small intestinal epithelium in culture over a prolonged period of time. Similarly no method has been published that describes isolation and support of human intestinal epithelium in an in vivo model. We describe a technique to isolate and maintain human small intestinal epithelium in vitro from surgical specimens. We also describe a novel method to maintain human intestinal epithelium subcutaneously in a mouse model for a prolonged period of time. Our methods require various growth factors and the intimate interaction between intestinal sub-epithelial myofibroblasts (ISEMFs) and the intestinal epithelial cells to support the epithelial in vitro and in vivo growth. Absence of these myofibroblasts precluded successful maintenance of epithelial cell formation and proliferation beyond just a few days, even in the presence of supportive growth factors. We believe that the methods described here can be used to explore the molecular basis of human intestinal stem cell support, maintenance, and growth. C1 [Lahar, Nicholas; Lei, Nan Ye; Jabaji, Ziyad; Tung, Stephaine C.; Stelzner, Matthias; Dunn, James C. Y.] Univ Calif Los Angeles, David Geffen Sch Med, Div Gastroenterol & Nutr, Dept Surg, Los Angeles, CA 90095 USA. [Lei, Nan Ye; Joshi, Vaidehi; Dunn, James C. Y.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Bioengn, Div Gastroenterol & Nutr, Los Angeles, CA 90095 USA. [Wang, Jiafang; Tung, Stephaine C.; Martin, Martin G.] Univ Calif Los Angeles, David Geffen Sch Med, Div Gastroenterol & Nutr, Dept Pediat, Los Angeles, CA 90095 USA. [Lewis, Michael] Univ Calif Los Angeles, Dept Pathol, Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90024 USA. RP Lahar, N (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Gastroenterol & Nutr, Dept Surg, Los Angeles, CA 90095 USA. EM jdunn@mednet.ucla.edu FU National Institute of Diabetes and Digestive and Kidney Diseases, Intestinal Stem Cell Consortium [DK085535-01, DK085535-02S2]; California Institute for Regenerative Medicine (CIRM) [RT2-01985]; [DK083762]; [DK083319] FX This work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases U01 Intestinal Stem Cell Consortium (DK085535-01 and DK085535-02S2), DK083762, DK083319 and the California Institute for Regenerative Medicine (CIRM) (Grant Number RT2-01985). The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of CIRM or any other agency of the State of California. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 18 TC 48 Z9 49 U1 2 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 17 PY 2011 VL 6 IS 11 AR e26898 DI 10.1371/journal.pone.0026898 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 855HZ UT WOS:000297555800010 PM 22125602 ER PT J AU De Franceschi, L Tomelleri, C Matte, A Brunati, AM Bovee-Geurts, PH Bertoldi, M Lasonder, E Tibaldi, E Danek, A Walker, RH Jung, HH Bader, B Siciliano, A Ferru, E Mohandas, N Bosman, GJCGM AF De Franceschi, Lucia Tomelleri, Carlo Matte, Alessandro Brunati, Anna Maria Bovee-Geurts, Petra H. Bertoldi, Mariarita Lasonder, Edwin Tibaldi, Elena Danek, Adrian Walker, Ruth H. Jung, Hans H. Bader, Benedikt Siciliano, Angela Ferru, Emanuela Mohandas, Narla Bosman, Giel J. C. G. M. TI Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity SO BLOOD LA English DT Article ID RED-CELL MEMBRANE; SRC FAMILY KINASES; PHOSPHORYLATION SITES; MULTIPROTEIN COMPLEX; MCLEOD-SYNDROME; NEUROACANTHOCYTOSIS; IDENTIFICATION; PLATELETS; PATHWAYS; VESICLES AB Acanthocytic RBCs are a peculiar diagnostic feature of chorea-acanthocytosis (ChAc), a rare autosomal recessive neurodegenerative disorder. Although recent years have witnessed some progress in the molecular characterization of ChAc, the mechanism(s) responsible for generation of acanthocytes in ChAc is largely unknown. As the membrane protein composition of ChAc RBCs is similar to that of normal RBCs, we evaluated the tyrosine (Tyr)-phosphorylation profile of RBCs using comparative proteomics. Increased Tyr phosphorylation state of several membrane proteins, including band 3, beta-spectrin, and adducin, was noted in ChAc RBCs. In particular, band 3 was highly phosphorylated on the Tyr-904 residue, a functional target of Lyn, but not on Tyr-8, a functional target of Syk. In ChAc RBCs, band 3 Tyr phosphorylation by Lyn was independent of the canonical Syk-mediated pathway. The ChAc-associated alterations in RBC membrane protein organization appear to be the result of increased Tyr phosphorylation leading to altered linkage of band 3 to the junctional complexes involved in anchoring the membrane to the cytoskeleton as supported by coimmunoprecipitation of beta-adducin with band 3 only in ChAc RBC-membrane treated with the Lyn-inhibitor PP2. We propose this altered association between membrane skeleton and membrane proteins as novel mechanism in the generation of acanthocytes in ChAc. (Blood. 2011;118(20):5652-5663) C1 [De Franceschi, Lucia; Tomelleri, Carlo; Matte, Alessandro; Siciliano, Angela; Ferru, Emanuela] Univ Verona, Dept Med, I-37134 Verona, Italy. [Brunati, Anna Maria; Tibaldi, Elena] Univ Padua, Dept Biochem, Padua, Italy. [Bovee-Geurts, Petra H.; Bosman, Giel J. C. G. M.] Radboud Univ Nijmegen, Med Ctr, Dept Biochem, NL-6525 ED Nijmegen, Netherlands. [Lasonder, Edwin] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, Ctr Mol & Biomol Informat, NL-6525 ED Nijmegen, Netherlands. [Bertoldi, Mariarita] Univ Verona, Biochem Sect, Dept Life & Reprod Sci, I-37134 Verona, Italy. [Danek, Adrian; Bader, Benedikt] Univ Munich, Dept Neurol, D-8000 Munich, Germany. [Walker, Ruth H.] James J Peters Vet Adm Med Ctr, Dept Neurol, Bronx, NY USA. [Walker, Ruth H.] Mt Sinai Sch Med, New York, NY USA. [Jung, Hans H.] Univ Zurich Hosp, CH-8091 Zurich, Switzerland. [Ferru, Emanuela] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy. [Mohandas, Narla] New York Blood Ctr, New York, NY 10021 USA. RP De Franceschi, L (reprint author), Univ Verona, Dept Med, Ple L Scuro 10, I-37134 Verona, Italy. EM lucia.defranceschi@univr.it RI Bosman, G.J.C.G.M./L-4221-2015; Danek, Adrian/G-7339-2011 OI Danek, Adrian/0000-0001-8857-5383 FU Advocacy for Neuroacanthocytosis Patients; Carl H. and Elizabeth S. Pforzheimer III, New York; Ginger and Glenn Irvine, London; Telethon [GPP07007] FX This work was supported by the Advocacy for Neuroacanthocytosis Patients (B. B., P. H. B.-G., E. L., G.J.C. G. M. B., and L. D. F.), Carl H. and Elizabeth S. Pforzheimer III, New York (B. B., P. H. B.-G., E. L., G.J.C. G. M. B., and R. H. W.), Ginger and Glenn Irvine, London (P. B., E. L., and G.J.C. G. M. B.) and Telethon (grant GPP07007, L. D. F.). Preliminary data were generated by Dr Christan Pozzobon. NR 47 TC 24 Z9 24 U1 0 U2 5 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 17 PY 2011 VL 118 IS 20 BP 5652 EP 5663 DI 10.1182/blood-2011-05-355339 PG 12 WC Hematology SC Hematology GA 851JT UT WOS:000297265400036 PM 21951684 ER PT J AU Chen, CH Panizzon, MS Eyler, LT Jernigan, TL Thompson, W Fennema-Notestine, C Jak, AJ Neale, MC Franz, CE Hamza, S Lyons, MJ Grant, MD Fischl, B Seidrnan, LJ Tsuang, MT Kremen, WS Dale, AM AF Chen, Chi-Hua Panizzon, Matthew S. Eyler, Lisa T. Jernigan, Terry L. Thompson, Wes Fennema-Notestine, Christine Jak, Amy J. Neale, Michael C. Franz, Carol E. Hamza, Samar Lyons, Michael J. Grant, Michael D. Fischl, Bruce Seidrnan, Larry J. Tsuang, Ming T. Kremen, William S. Dale, Anders M. TI Genetic Influences on Cortical Regionalization in the Human Brain SO NEURON LA English DT Article ID SURFACE-BASED ANALYSIS; CEREBRAL-CORTEX; COORDINATE SYSTEM; AREA IDENTITY; ASSOCIATION; THICKNESS; NEOCORTEX; INSIGHTS; PAX6; MICE AB Animal data demonstrate that the development of distinct cortical areas is influenced by genes that exhibit highly regionalized expression patterns. In this paper, we show genetic patterning of cortical surface area derived from MRI data from 406 adult human twins. We mapped genetic correlations of areal expansion between selected seed regions and all other cortical locations, with the selection of seed points based on results from animal studies. "Marching seeds" and a data-driven, hypothesis-free, fuzzy-clustering approach provided convergent validation. The results reveal strong anterior-to-posterior graded, bilaterally symmetric patterns of regionalization, largely consistent with patterns previously reported in nonhuman mammalian models. Broad similarities in genetic patterning between rodents and humans might suggest a conservation of cortical patterning mechanisms, whereas dissimilarities might reflect the functionalities most essential to each species. C1 [Chen, Chi-Hua; Panizzon, Matthew S.; Eyler, Lisa T.; Jernigan, Terry L.; Thompson, Wes; Fennema-Notestine, Christine; Jak, Amy J.; Franz, Carol E.; Hamza, Samar; Tsuang, Ming T.; Kremen, William S.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Jernigan, Terry L.] Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA. [Tsuang, Ming T.; Kremen, William S.] Univ Calif San Diego, Ctr Behav Genom, La Jolla, CA 92093 USA. [Fennema-Notestine, Christine; Dale, Anders M.] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA. [Dale, Anders M.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA. [Eyler, Lisa T.; Jak, Amy J.; Tsuang, Ming T.; Kremen, William S.] VA San Diego Healthcare Syst, San Diego, CA 92161 USA. [Neale, Michael C.] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA 23298 USA. [Neale, Michael C.] Virginia Commonwealth Univ, Dept Human & Mol Genet, Richmond, VA 23298 USA. [Fischl, Bruce] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Fischl, Bruce] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02114 USA. [Lyons, Michael J.; Grant, Michael D.] Boston Univ, Dept Psychol, Boston, MA 02215 USA. [Seidrnan, Larry J.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA. RP Kremen, WS (reprint author), Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. EM wkremen@ucsd.edu OI Lyons, Michael/0000-0001-6516-9219; Fennema-Notestine, Christine/0000-0002-6527-6361 FU National Institute on Aging [AG022381, AG018386, AG018384, AG022982, AG031224]; National Institute of Drug Abuse [DA029475]; National Institute of Neurological Disorders and Stroke [NS056883, NS052585-01, 1R21NS072652-01, 1R01NS070963]; National Center for Research Resources [P41-RR14075, BIRN002, U24 RR021382]; National Institute for Biomedical Imaging and Bioengineering [EB006758]; National Center for Alternative Medicine [RC1 AT005728-01]; Ellison Medical Foundation; U.S. Department of Veterans Affairs FX Funded by National Institute on Aging (AG022381, AG018386, AG018384, AG022982, AG031224), National Institute of Drug Abuse (DA029475), National Institute of Neurological Disorders and Stroke (NS056883), National Center for Research Resources (P41-RR14075, BIRN002, U24 RR021382), National Institute for Biomedical Imaging and Bioengineering (EB006758), National Center for Alternative Medicine (RC1 AT005728-01), National Institute for Neurological Disorders and Stroke (NS052585-01, 1R21NS072652-01, 1R01NS070963), and the Ellison Medical Foundation. The U.S. Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin Registry. Anders M. Dale is a founder and holds equity in CorTechs Laboratories, Inc. and also serves on its Scientific Advisory Board. The terms of this arrangement have been reviewed and approved by the University of California, San Diego, in accordance with its conflict of interest policies. NR 34 TC 49 Z9 49 U1 0 U2 3 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0896-6273 J9 NEURON JI Neuron PD NOV 17 PY 2011 VL 72 IS 4 BP 537 EP 544 DI 10.1016/j.neuron.2011.08.021 PG 8 WC Neurosciences SC Neurosciences & Neurology GA 850FI UT WOS:000297180100006 PM 22099457 ER PT J AU Singh, KK De Rienzo, G Drane, L Mao, YW Flood, Z Madison, J Ferreira, M Bergen, S King, C Sklar, P Sive, H Tsai, LH AF Singh, Karun K. De Rienzo, Gianluca Drane, Laurel Mao, Yingwei Flood, Zachary Madison, Jon Ferreira, Manuel Bergen, Sarah King, Cillian Sklar, Pamela Sive, Hazel Tsai, Li-Huei TI Common DISC1 Polymorphisms Disrupt Wnt/GSK3 beta Signaling and Brain Development SO NEURON LA English DT Article ID CANONICAL WNT PATHWAY; IN-SCHIZOPHRENIA 1; CORTICAL DEVELOPMENT; POSITIVE SYMPTOMS; BIPOLAR DISORDER; CEREBRAL-CORTEX; LITHIUM; COMPLEX; RISK; DIFFERENTIATION AB Disrupted in Schizophrenia-1 (DISCI) is a candidate gene for psychiatric disorders and has many roles during brain development. Common DISCI polymorphisms (variants) are associated with neuropsychiatric phenotypes including altered cognition, brain structure, and function; however, it is unknown how this occurs. Here, we demonstrate using mouse, zebrafish, and human model systems that DISCI variants are loss of function in Wnt/GSK3 beta signaling and disrupt brain development. The DISCI variants A83V, R264Q, and L607F, but not S704C, do not activate Wnt signaling compared with wild-type DISC1 resulting in decreased neural progenitor proliferation. In zebrafish, R264Q and L607F could not rescue DISCI knockdown-mediated aberrant brain development. Furthermore, human lymphoblast cell lines endogenously expressing R264Q displayed impaired Wnt signaling. Interestingly, S704C inhibited the migration of neurons in the developing neocortex. Our data demonstrate DISC1 variants impair Wnt signaling and brain development and elucidate a possible mechanism for their role in neuropsychiatric phenotypes. C1 [Singh, Karun K.; Drane, Laurel; Mao, Yingwei; Flood, Zachary; King, Cillian; Tsai, Li-Huei] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA. [Singh, Karun K.; Drane, Laurel; Mao, Yingwei; Flood, Zachary; King, Cillian; Tsai, Li-Huei] MIT, Picower Inst Learning & Memory, Cambridge, MA 02139 USA. [Singh, Karun K.; Drane, Laurel; Mao, Yingwei; Flood, Zachary; King, Cillian; Tsai, Li-Huei] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA. [Singh, Karun K.; De Rienzo, Gianluca; Drane, Laurel; Mao, Yingwei; Flood, Zachary; Madison, Jon; Ferreira, Manuel; Bergen, Sarah; King, Cillian; Sklar, Pamela; Sive, Hazel; Tsai, Li-Huei] Broad Inst, Stanley Ctr Psychiat Res, Cambridge, MA 02139 USA. [Ferreira, Manuel; Bergen, Sarah; Sklar, Pamela] Massachusetts Gen Hosp, Dept Ctr Human Genet Res, Boston, MA 02114 USA. [De Rienzo, Gianluca; Sive, Hazel] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. RP Tsai, LH (reprint author), MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA. EM lhtsai@mit.edu RI Bergen, Sarah/I-8313-2012; OI Bergen, Sarah/0000-0002-5888-0034 FU Human Frontiers Science Program Long-term fellowship; NSERC; National Alliance for Research on Schizophrenia and Depression; NIH [MH091115]; Stanley Center for Psychiatric Research FX We would like to thank Tsai lab members and Stanley Center members for helpful discussions. We would like to give a special thanks to Janice Kranz, Kimberly Chambert, Doug Ruderfer, Doug Barker, Jennifer Moran, and Edward M. Scolnick for their intellectual input and logistical support. L.-H.T. is an investigator of the Howard Hughes Medical Institute and the director of the neurobiology program at the Stanley Center for Psychiatric Research. K.K.S. is a recipient of the Human Frontiers Science Program Long-term fellowship and an NSERC postdoctoral fellowship. Y.M. is a recipient of the National Alliance for Research on Schizophrenia and Depression Young Investigator Award. This work was partially supported by a NIH RO1 grant (MH091115) to L.-H.T. and a grant from the Stanley Center for Psychiatric Research to L.-H.T. NR 42 TC 62 Z9 64 U1 2 U2 16 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0896-6273 J9 NEURON JI Neuron PD NOV 17 PY 2011 VL 72 IS 4 BP 545 EP 558 DI 10.1016/j.neuron.2011.09.030 PG 14 WC Neurosciences SC Neurosciences & Neurology GA 850FI UT WOS:000297180100007 PM 22099458 ER PT J AU Soper, DE Lee, SI Kim, JY McDonald, AG AF Soper, David E. Lee, Susanna I. Kim, Ji Yeon McDonald, Anna G. TI Case 35-2011: A 33-Year-Old Woman with Postpartum Leukocytosis and Gram-Positive Bacteremia SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID CLOSTRIDIUM-PERFRINGENS; GENITAL-TRACT; INFECTION; SORDELLII; MICROBIOLOGY; ENDOMETRITIS; MANAGEMENT; DELIVERY; ABORTION; SEPSIS C1 [Soper, David E.] Med Univ S Carolina, Dept Obstet & Gynecol, Charleston, SC 29425 USA. [Lee, Susanna I.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Kim, Ji Yeon; McDonald, Anna G.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Lee, Susanna I.] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA. [Kim, Ji Yeon; McDonald, Anna G.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA. RP Soper, DE (reprint author), Med Univ S Carolina, Dept Obstet & Gynecol, Charleston, SC 29425 USA. FU Merck FX Dr. Soper reports that his institution has received grant support from Merck. No other potential conflict of interest relevant to this article was reported. Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. NR 22 TC 3 Z9 3 U1 0 U2 1 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 17 PY 2011 VL 365 IS 20 BP 1916 EP 1924 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 848HG UT WOS:000297041900011 PM 22087683 ER PT J AU Jena, AB Seabury, SA Chandra, A AF Jena, Anupam B. Seabury, Seth A. Chandra, Amitabh TI Malpractice Risk According to Physician Specialty SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Jena, Anupam B.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Chandra, Amitabh] Harvard Univ, Cambridge, MA 02138 USA. RP Jena, AB (reprint author), Massachusetts Gen Hosp, Boston, MA 02114 USA. EM amitabh_chandra@harvard.edu NR 0 TC 0 Z9 0 U1 0 U2 4 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 17 PY 2011 VL 365 IS 20 BP 1940 EP 1940 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 848HG UT WOS:000297041900027 ER PT J AU Restivo, G Nguyen, BC Dziunycz, P Ristorcelli, E Ryan, RJH Ozuysal, OY Di Piazza, M Radtke, F Dixon, MJ Hofbauer, GFL Lefort, K Dotto, GP AF Restivo, Gaetana Bach-Cuc Nguyen Dziunycz, Piotr Ristorcelli, Elodie Ryan, Russell J. H. Oezuysal, Oezden Yalcin Di Piazza, Matteo Radtke, Freddy Dixon, Michael J. Hofbauer, Guenther F. L. Lefort, Karine Dotto, G. Paolo TI IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes SO EMBO JOURNAL LA English DT Article DE keratinocytes; Notch; p63; squamous cell carcinoma; tumour suppression ID INTERFERON REGULATORY FACTOR-6; NF-KAPPA-B; EPIDERMAL DIFFERENTIATION; TRANSCRIPTION FACTORS; SIGNALING PATHWAY; STEM-CELLS; P63; SKIN; CANCER; ACTIVATION AB While the pro-differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain poorly understood. We report here that interferon regulatory factor 6 (IRF6), an IRF family member with an essential role in epidermal development, is induced in differentiation through a Notch-dependent mechanism and is a primary Notch target in keratinocytes and keratinocyte-derived SCC cells. Increased IRF6 expression contributes to the impact of Notch activation on growth/differentiation-related genes, while it is not required for induction of 'canonical' Notch targets like p21 WAF1/Cip1, Hes1 and Hey1. Down-modulation of IRF6 counteracts differentiation of primary human keratinocytes in vitro and in vivo, promoting ras-induced tumour formation. The clinical relevance of these findings is illustrated by the strikingly opposite pattern of expression of Notch1 and IRF6 versus epidermal growth factor receptor in a cohort of clinical SCCs, as a function of their grade of differentiation. Thus, IRF6 is a primary Notch target in keratinocytes, which contributes to the role of this pathway in differentiation and tumour suppression. The EMBO Journal (2011) 30, 4571-4585. doi:10.1038/emboj.2011.325; Published online 9 September 2011 Subject Categories: signal transduction; molecular biology of disease C1 [Restivo, Gaetana; Ristorcelli, Elodie; Lefort, Karine; Dotto, G. Paolo] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland. [Bach-Cuc Nguyen; Dotto, G. Paolo] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA USA. [Dziunycz, Piotr; Hofbauer, Guenther F. L.] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland. [Ryan, Russell J. H.] Massachusetts Gen Hosp, Dept Pathol, Howard Hughes Med Inst, Boston, MA 02114 USA. [Oezuysal, Oezden Yalcin; Di Piazza, Matteo; Radtke, Freddy] Ecole Polytech Fed Lausanne, Fac Life Sci, Lausanne, Switzerland. [Dixon, Michael J.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Med & Human Sci, Manchester, Lancs, England. [Dixon, Michael J.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Life Sci, Manchester, Lancs, England. RP Lefort, K (reprint author), Univ Lausanne, Dept Biochem, Chemin Boveresses 155, CH-1066 Epalinges, Switzerland. EM Karine.Lefort@unil.ch; Paolo.Dotto@unil.ch RI Hofbauer, Gunther/B-2671-2010; OI Hofbauer, Gunther/0000-0003-0542-7989; Yalcin-Ozuysal, Ozden/0000-0003-0552-368X FU NIH [AR39190, AR054856]; European Union [LSHB-CT-2005-019067]; Swiss National Foundation [3100A0-122281/1]; Oncosuisse [02361-02-2009]; Olga-Mayenfisch-Stiftung; Wellcome Trust [082868]; MRC [G 0901539] FX We thank Drs B Schutte, U Just, J Aster, P Khavari, J Rocco, J Rheinwald for gifts of plasmids and cells and I Bernstein for its generous gift of IgG-Deltaext-myc ligand. This work was supported by grants from NIH (Grants AR39190 and AR054856), the European Union (Epistem, Sixth Framework Program, LSHB-CT-2005-019067), the Swiss National Foundation (Grant 3100A0-122281/1) and Oncosuisse (Grant 02361-02-2009) to GPD, and by a grant from the Olga-Mayenfisch-Stiftung to GH and by grants from Wellcome Trust (082868) and MRC (G 0901539) to MJD. NR 62 TC 50 Z9 50 U1 0 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0261-4189 J9 EMBO J JI Embo J. PD NOV 16 PY 2011 VL 30 IS 22 BP 4571 EP 4585 DI 10.1038/emboj.2011.325 PG 15 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 857CI UT WOS:000297691500006 PM 21909072 ER PT J AU Reichmann, WM Walensky, RP Case, A Novais, A Arbelaez, C Katz, JN Losina, E AF Reichmann, William M. Walensky, Rochelle P. Case, Amy Novais, Anna Arbelaez, Christian Katz, Jeffrey N. Losina, Elena TI Estimation of the Prevalence of Undiagnosed and Diagnosed HIV in an Urban Emergency Department SO PLOS ONE LA English DT Article ID INNER-CITY EMERGENCY; IMMUNODEFICIENCY VIRUS-INFECTION; SEVERITY INDEX; ADOLESCENTS; ADULTS; WOMEN AB Objective: To estimate the prevalence of undiagnosed HIV, the prevalence of diagnosed HIV, and proportion of HIV that is undiagnosed in populations with similar demographics as the Universal Screening for HIV in the Emergency Room (USHER) Trial and the Brigham and Women's Hospital (BWH) Emergency Department (ED) in Boston, MA. We also sought to estimate these quantities within demographic and risk behavior subgroups. Method: We used data from the USHER Trial, which was a randomized clinical trial of HIV screening conducted in the BWH ED. Since eligible participants were HIV-free at time of enrollment, we were able to calculate the prevalence of undiagnosed HIV. We used data from the Massachusetts Department of Public Health (MA/DPH) to estimate the prevalence of diagnosed HIV since the MA/DPH records the number of persons within MA who are HIV-positive. We calculated the proportion of HIV that is undiagnosed using these estimates of the prevalence of undiagnosed and diagnosed HIV. Estimates were stratified by age, sex, race/ethnicity, history of testing, and risk behaviors. Results: The overall expected prevalence of diagnosed HIV in a population similar to those presenting to the BWH ED was 0.71% (95% CI: 0.63%, 0.78%). The prevalence of undiagnosed HIV was estimated at 0.22% (95% CI: 0.10%, 0.42%) and resultant overall prevalence was 0.93%. The proportion of HIV-infection that is undiagnosed in this ED-based setting was estimated to be 23.7% (95% CI: 11.6%, 34.9%) of total HIV-infections. Conclusions: Despite different methodology, our estimate of the proportion of HIV that is undiagnosed in an ED-setting was similar to previous estimates based on national surveillance data. Universal routine testing programs in EDs should use these data to help plan their yield of HIV detection. C1 [Reichmann, William M.; Katz, Jeffrey N.; Losina, Elena] Brigham & Womens Hosp, Dept Orthoped Surg, Boston, MA 02115 USA. [Reichmann, William M.; Losina, Elena] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. [Walensky, Rochelle P.; Losina, Elena] Harvard Univ, Sch Med, Ctr AIDS Res, Boston, MA USA. [Walensky, Rochelle P.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Walensky, Rochelle P.] Massachusetts Gen Hosp, Div Gen Med, Boston, MA 02114 USA. [Case, Amy; Novais, Anna; Arbelaez, Christian] Brigham & Womens Hosp, Dept Emergency Med, Boston, MA 02115 USA. [Walensky, Rochelle P.] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Katz, Jeffrey N.] Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA. [Katz, Jeffrey N.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Reichmann, WM (reprint author), Brigham & Womens Hosp, Dept Orthoped Surg, 75 Francis St, Boston, MA 02115 USA. EM wreichmann@partners.org OI Walensky, Rochelle P./0000-0002-8795-379X FU National Institute of Mental Health [R01 MH073445, R01 MH65869]; National Institute of Arthritis and Skin Diseases [K24 AR 057827]; Doris Duke Charitable Foundation FX This research was funded by the National Institute of Mental Health (R01 MH073445, R01 MH65869), National Institute of Arthritis and Skin Diseases (K24 AR 057827) and the Doris Duke Charitable Foundation, Clinical Scientist Development Award to Rochelle P. Walensky. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 3 Z9 3 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 16 PY 2011 VL 6 IS 11 AR e27701 DI 10.1371/journal.pone.0027701 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 855HV UT WOS:000297555400089 PM 22110730 ER PT J AU Serghides, L Kim, H Lu, ZY Kain, DC Miller, C Francis, RC Liles, WC Zapol, WM Kain, KC AF Serghides, Lena Kim, Hani Lu, Ziyue Kain, Dylan C. Miller, Chris Francis, Roland C. Liles, W. Conrad Zapol, Warren M. Kain, Kevin C. TI Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria SO PLOS ONE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; INTERCELLULAR-ADHESION MOLECULE-1; ISCHEMIA-REPERFUSION INJURY; AFRICAN CHILDREN; PROINFLAMMATORY CYTOKINES; UNCOMPLICATED MALARIA; COGNITIVE IMPAIRMENT; MYOCARDIAL-ISCHEMIA; ADJUNCTIVE THERAPY; LEUKOCYTE ADHESION AB The host immune response contributes to the onset and progression of severe malaria syndromes, such as cerebral malaria. Adjunctive immunomodulatory strategies for severe malaria may improve clinical outcome beyond that achievable with artemisinin-based therapy alone. Here, we report that prophylaxis with inhaled nitric oxide significantly reduced systemic inflammation (lower TNF, IFN gamma and MCP-1 in peripheral blood) and endothelial activation (decreased sICAM-1 and vWF, and increased angiopoeitin-1 levels in peripheral blood) in an experimental cerebral malaria model. Mice that received inhaled nitric oxide starting prior to infection had reduced parasitized erythrocyte accumulation in the brain, decreased brain expression of ICAM-1, and preserved vascular integrity compared to control mice. Inhaled nitric oxide administered in combination with artesunate, starting as late as 5.5 days post-infection, improved survival over treatment with artesunate alone (70% survival in the artesunate only vs. 100% survival in the artesunate plus iNO group, p = 0.03). These data support the clinical investigation of inhaled nitric oxide as a novel adjunctive therapy in patients with severe malaria. C1 [Serghides, Lena; Kim, Hani; Lu, Ziyue; Kain, Dylan C.; Liles, W. Conrad; Kain, Kevin C.] Toronto Gen Hosp, Dept Med, McLaughlin Rotman Ctr Global Hlth,Div Infect Dis, SA Rotman Labs,Trop Dis Unit,Univ Hlth Network, Toronto, ON M5G 1L7, Canada. [Serghides, Lena; Kim, Hani; Lu, Ziyue; Kain, Dylan C.; Liles, W. Conrad; Kain, Kevin C.] Univ Toronto, Toronto, ON, Canada. [Miller, Chris] Univ British Columbia, Fac Med, Dept Resp Med, Vancouver, BC, Canada. [Francis, Roland C.; Zapol, Warren M.] Massachusetts Gen Hosp, Anesthesia Ctr Crit Care Res, Boston, MA 02114 USA. RP Serghides, L (reprint author), Toronto Gen Hosp, Dept Med, McLaughlin Rotman Ctr Global Hlth,Div Infect Dis, SA Rotman Labs,Trop Dis Unit,Univ Hlth Network, Toronto, ON M5G 1L7, Canada. EM kevin.kain@uhn.on.ca FU Canadian Institutes of Health Research [MOP-13721, 244701]; Canada Research Chair; Ontario HIV Treatment Network [287]; Defense Advanced Research Projects Agency [58217-LS-DRP] FX This work was supported by the Canadian Institutes of Health Research MOP-13721 and 244701 [KCK], Canada Research Chair [KCK, WCL], an Ontario HIV Treatment Network Junior Investigator Salary Award 287 [LS], and a Defense Advanced Research Projects Agency grant 58217-LS-DRP [KCK]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 91 TC 34 Z9 34 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 16 PY 2011 VL 6 IS 11 AR e27714 DI 10.1371/journal.pone.0027714 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 855HV UT WOS:000297555400094 PM 22110737 ER PT J AU Souer, JS Ring, D Jupiter, J Matschke, S Audige, L Marent-Huber, M AF Souer, J. Sebastiaan Ring, David Jupiter, Jesse Matschke, Stefan Audige, Laurent Marent-Huber, Marta CA LCP Distal Radius Study Grp TI Comparison of Intra-Articular Simple Compression and Extra-Articular Distal Radial Fractures SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID PLATE FIXATION; YOUNG-ADULTS; REDUCTION; END AB Background: The impact of a single well-reduced or stable intra-articular fracture oriented in the sagittal plane on the outcome of internal fixation of a distal radial fracture is uncertain. We tested the hypothesis that wrist motion and function scores would not differ between patients with an extra-articular fracture and those with a single. sagittal intra-articular fracture following open fracture reduction and internal fixation with use of a volar locking plate. Methods: Thirty-seven patients with a single sagittal intra-articular fracture of the distal aspect of the radius and seventy-four age and sex-matched patients with an extra-articular distal radial fracture were retrospectively analyzed with use of data gathered in a cohort study of plate and screw fixation of distal radial fractures. A volar locking plate was used in all patients. The two cohorts were analyzed for differences in motion, grip strength, pain, and Gartland and Werley, DASH (Disabilities of the Arm, Shoulder and Hand), and SF-36 (Short Form-36) scores six, twelve, and twenty-four months after surgery. Differences between the cohorts and differences within each cohort over time were determined with use of regression analysis and the likelihood ratio test. Results: Patients with a single sagittal intra-articular fracture and those an extra-articular fracture, did not differ significantly with respect to motion, grip strength, Gartland and Werley score, or DASH score at any time point. However, there was a trend toward less pronation (95% compared with 98% of that in the contralateral arm) and less grip strength (76% compared with 81% of that in the contralateral arm) at six months and toward a smaller flexion-extension arc (118 degrees compared with 128 degrees) at one year after surgery in patients with a single sagittal intra-articular fracture. Conclusions: Open reduction and volar locking plate and screw fixation of extra-articular fractures and of simple intra-articular fractures of the distal aspect of the radius are associated with comparable impairment and disability within two years of surgery. RP Souer, JS (reprint author), Massachusetts Gen Hosp, Yawkey 2100,55 Fruit St, Boston, MA 02114 USA. EM dring@partners.org RI AOCID, AO Foundation/R-6455-2016 NR 23 TC 5 Z9 5 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD NOV 16 PY 2011 VL 93A IS 22 BP 2093 EP 2099 DI 10.2106/JBJS.J.01069 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 848VC UT WOS:000297082200007 PM 22262381 ER PT J AU Cannon, CP AF Cannon, Christopher P. TI High-Density Lipoprotein Cholesterol as the Holy Grail SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID CORONARY-HEART-DISEASE; ESTER TRANSFER PROTEIN; LDL CHOLESTEROL; BLOOD-PRESSURE; HIGH-RISK; SAFETY; TRIAL; ANACETRAPIB; TORCETRAPIB; DALCETRAPIB C1 Brigham & Womens Hosp, TIMI Study Grp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA. RP Cannon, CP (reprint author), Brigham & Womens Hosp, TIMI Study Grp, Dept Med, Div Cardiovasc, 350 Longwood Ave,1st Floor, Boston, MA 02115 USA. EM cpcannon@partners.org NR 23 TC 8 Z9 9 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 16 PY 2011 VL 306 IS 19 BP 2153 EP 2155 DI 10.1001/jama.2011.1687 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 847YU UT WOS:000297013000025 PM 22089726 ER PT J AU Bekelman, JE Mitra, N Efstathiou, J Liao, KJ Sunderland, R Yeboa, DN Armstrong, K AF Bekelman, Justin E. Mitra, Nandita Efstathiou, Jason Liao, Kaijun Sunderland, Robert Yeboa, Deborah N. Armstrong, Katrina TI OUTCOMES AFTER INTENSITY-MODULATED VERSUS CONFORMAL RADIOTHERAPY IN OLDER MEN WITH NONMETASTATIC PROSTATE CANCER SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Prostate cancer; Comparative effectiveness research; IMRT ID RANDOMIZED CONTROLLED-TRIALS; RADIATION-THERAPY; RADICAL PROSTATECTOMY; PROPENSITY SCORE; NORMAL TISSUE; ELDERLY-MEN; HEALTH-CARE; COMPLICATIONS; VOLUME; TOXICITY AB Purpose: There is little evidence comparing complications after intensity-modulated (IMRT) vs. three-dimensional conformal radiotherapy (CRT) for prostate cancer. The study objective was to test the hypothesis that IMRT, compared with CRT, is associated with a reduction in bowel, urinary, and erectile complications in elderly men with nonmetastatic prostate cancer. Methods and Materials: We undertook an observational cohort study using registry and administrative claims data from the SEER-Medicare database. We identified men aged 65 years or older diagnosed with nonmetastatic prostate cancer in the United States between 2002 and 2004 who received IMRT (n = 5,845) or CRT (n = 6,753). The primary outcome was a composite measure of bowel complications. Secondary outcomes were composite measures of urinary and erectile complications. We also examined specific subsets of bowel (proctitis/hemorrhage) and urinary (cystitis/hematuria) events within the composite complication measures. Results: IMRT was associated with reductions in composite bowel complications (24-month cumulative incidence 18.8% vs. 22.5%; hazard ratio [HR] 0.86; 95% confidence interval [CI], 0.79-0.93) and proctitis/hemorrhage (HR 0.78; 95% CI, 0.64-0.95). IMRT was not associated with rates of composite urinary complications (HR 0.93; 95% CI, 0.83-1.04) or cystitis/hematuria (HR 0.94; 95% CI, 0.83-1.07). The incidence of erectile complications involving invasive procedures was low and did not differ significantly between groups, although IMRT was associated with an increase in new diagnoses of impotence (HR 1.27, 95% CI, 1.14-1.42). Conclusion: IMRT is associated with a small reduction in composite bowel complications and proctitis/hemorrhage compared with CRT in elderly men with nonmetastatic prostate cancer. (C) 2011 Elsevier Inc. C1 [Bekelman, Justin E.] Univ Penn, Abramson Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19104 USA. [Mitra, Nandita; Armstrong, Katrina] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. [Efstathiou, Jason] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. [Liao, Kaijun; Armstrong, Katrina] Univ Penn, Div Gen Internal Med, Philadelphia, PA 19104 USA. [Bekelman, Justin E.; Armstrong, Katrina] Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA. RP Bekelman, JE (reprint author), Univ Penn, Abramson Canc Ctr, Dept Radiat Oncol, 3400 Spruce St,2 Donner Bldg, Philadelphia, PA 19104 USA. EM bekelman@uphs.upenn.edu FU American Cancer Society [IRG-78-002-29]; National Institutes of Health; Department of Defense; Robert Wood Johnson Foundation FX This paper was supported in part by funds from Grant No. IRG-78-002-29 from the American Cancer Society.; Dr. Bekelman reports serving as a consultant for the Riverside Company and receiving grants to his institution from the American Cancer Society and philanthropic sources. Dr. Armstrong reports receiving grants to her institution from the National Institutes of Health, the Department of Defense, the American Cancer Society, and the Robert Wood Johnson Foundation. All other authors report no potential conflicts of interest. NR 54 TC 47 Z9 47 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E325 EP E334 DI 10.1016/j.ijrobp.2011.02.006 PG 10 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300017 PM 21498008 ER PT J AU Chakravarthy, AB Catalano, PJ Martenson, JA Mondschein, JK Wagner, H Mansour, EG Talamonti, MS Benson, AB AF Chakravarthy, A. Bapsi Catalano, Paul J. Martenson, James. A. Mondschein, Joshua K. Wagner, Henry Mansour, Edward G. Talamonti, Mark S. Benson, Al Bowen TI LONG-TERM FOLLOW-UP OF A PHASE II TRIAL OF HIGH-DOSE RADIATION WITH CONCURRENT 5-FLUOROURACIL AND CISPLATIN IN PATIENTS WITH ANAL CANCER (ECOG E4292) SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Cisplatinum; CDDP; Sphincter preservation; Induction chemotherapy; Maintenance chemotherapy ID CANAL CARCINOMA; RADIOTHERAPY; FLUOROURACIL; THERAPY; CHEMORADIATION; EXPERIENCE; MITOMYCIN AB Purpose: Although chemoradiation using 5-fluorouracil (5-FU) and mitomycin-C (MMC) is the standard of care in the treatment of anal cancer, many patients are unable to tolerate MMC. This Phase II clinical trial was performed to determine whether cisplatin could replace MMC in the treatment of anal cancer. Methods and Materials: Thirty-three patients with localized anal cancer were enrolled. One patient registered but never received any assigned therapy and was excluded from all analyses. Between February 1, 1993, and July 21, 1993, 19 patients were accrued to Cohort 1. Radiation consisted of 45 Gy to the primary tumor and pelvic nodes, followed by a boost to the primary and involved nodes to 59.4 Gy. A planned 2-week treatment break was used after 36 Gy. Concurrent chemotherapy consisted of 5-FU 1,000 mg/m(2)/day on Days 1 to 4 and cisplatin 75 mg/m(2) on Day 1. A second course of 5-FU and cisplatin was given after 36 Gy, when the patient resumed radiation therapy. Between April 4, 1996, and September 23, 1996, an additional 13 patients (Cohort 2) were accrued to the study and received the same treatment except without the planned treatment break. Results: Complete response was seen in 78% (90% CI, 63-89) of patients and was higher in patients who did not get a planned treatment break (92% vs. 68%). The overall Grade 4 toxicity rate was 31%. One treatment-related death (Grade 5) occurred in a patient who developed sepsis. The 5-year overall survival was 69%. Conclusions: Radiation therapy, cisplatin, and 5-FU resulted in an overall objective response (complete response + partial response) of 97%. Although the 5-year progression-free survival was only 55%, the overall 5-year survival was 69%. Given the excellent salvage provided by surgery, this study affirms that cisplatin-based regimens may be an alternative for patients who cannot tolerate the severe hematologic toxicities associated with mitomycin-based chemoradiation regimens. (C) 2011 Elsevier Inc. C1 [Chakravarthy, A. Bapsi] Vanderbilt Univ, Med Ctr, Dept Radiat Oncol, Nashville, TN 37232 USA. [Catalano, Paul J.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Martenson, James. A.] Mayo Clin, Rochester, MN USA. [Wagner, Henry] Penn State Hershey Canc Inst, Hershey, PA USA. [Mansour, Edward G.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Talamonti, Mark S.] Univ Chicago, Pritzker Sch Med, Evanston, IL USA. [Benson, Al Bowen] Northwestern Univ, Chicago, IL 60611 USA. RP Chakravarthy, AB (reprint author), Vanderbilt Univ, Med Ctr, Dept Radiat Oncol, 2220 Pierce Ave,Preston Res Bldg,Room B-1003, Nashville, TN 37232 USA. EM bapsi.chak@vanderbilt.edu FU Public Health Service from the National Cancer Institute, National Institutes of Health [CA13650, CA23318, CA15488, CA14548, CA17145, CA21115]; Department of Health and Human Services FX This study was conducted by the Eastern Cooperative Oncology Group and supported in part by Public Health Service grants CA13650, CA23318, CA15488, CA14548, CA17145, and CA21115 from the National Cancer Institute, National Institutes of Health, and the Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute. NR 15 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E607 EP E613 DI 10.1016/j.ijrobp.2011.02.042 PG 7 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300054 PM 21514072 ER PT J AU Margalit, DN Chen, YH Catalano, PJ Heckman, K Vivenzio, T Nissen, K Wolfsberger, LD Cormack, RA Mauch, P Ng, AK AF Margalit, Danielle N. Chen, Yu-Hui Catalano, Paul J. Heckman, Kenneth Vivenzio, Todd Nissen, Kristopher Wolfsberger, Luciant D. Cormack, Robert A. Mauch, Peter Ng, Andrea K. TI TECHNOLOGICAL ADVANCEMENTS AND ERROR RATES IN RADIATION THERAPY DELIVERY SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Quality assurance; Quality improvement; Intensity-modulated radiation therapy; Errors in radiation therapy; patient safety ID QUALITY-ASSURANCE; AMERICAN-SOCIETY; ONCOLOGY; IMPACT; RADIOTHERAPY; MEDICINE AB Purpose: Technological advances in radiation therapy (RT) delivery have the potential to reduce errors via increased automation and built-in quality assurance (QA) safeguards, yet may also introduce new types of errors. Intensity-modulated RT (IMRT) is an increasingly used technology that is more technically complex than three-dimensional (3D)-conformal RT and conventional RT. We determined the rate of reported errors in RT delivery among IMRT and 3D/conventional RT treatments and characterized the errors associated with the respective techniques to improve existing QA processes. Methods and Materials: All errors in external beam RT delivery were prospectively recorded via a nonpunitive error-reporting system at Brigham & Women's Hospital/Dana Farber Cancer Institute. Errors are defined as any unplanned deviation from the intended RT treatment and are reviewed during monthly departmental quality improvement meetings. We analyzed all reported errors since the routine use of IMRT in our department, from January 2004 to July 2009. Fisher's exact test was used to determine the association between treatment technique (IMRT vs. 3D/conventional) and specific error types. Effect estimates were computed using logistic regression. Results: There were 155 errors in RT delivery among 241,546 fractions (0.06%), and none were clinically significant. IMRT was commonly associated with errors in machine parameters (nine of 19 errors) and data entry and interpretation (six of 19 errors). IMRT was associated with a lower rate of reported errors compared with 3D/conventional RT (0.03% vs. 0.07%, p = 0.001) and specifically fewer accessory errors (odds ratio, 0.11; 95% confidence interval, 0.01-0.78) and setup errors (odds ratio, 0.24; 95% confidence interval, 0.08-0.79). Conclusions: The rate of errors in RT delivery is low. The types of errors differ significantly between IMRT and 3D/conventional RT, suggesting that QA processes must be uniquely adapted for each technique. There was a lower error rate with IMRT compared with 3D/conventional RT, highlighting the need for sustained vigilance against errors common to more traditional treatment techniques. (C) 2011 Elsevier Inc. C1 [Margalit, Danielle N.] Harvard Radiat Oncol Program, Boston, MA USA. [Margalit, Danielle N.; Chen, Yu-Hui; Catalano, Paul J.; Heckman, Kenneth; Vivenzio, Todd; Nissen, Kristopher; Wolfsberger, Luciant D.; Cormack, Robert A.; Mauch, Peter; Ng, Andrea K.] Harvard Canc Consortium, Boston, MA USA. [Margalit, Danielle N.; Chen, Yu-Hui; Catalano, Paul J.; Heckman, Kenneth; Vivenzio, Todd; Nissen, Kristopher; Wolfsberger, Luciant D.; Cormack, Robert A.; Mauch, Peter; Ng, Andrea K.] Brigham & Womens Hosp, Dana Farber Canc Inst, Boston, MA 02115 USA. RP Margalit, DN (reprint author), Dept Radiat Oncol, 75 Francis St,LL2, Boston, MA 02115 USA. EM dmargalit@partners.org OI Cormack, Robert/0000-0001-5553-9984 NR 20 TC 8 Z9 9 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E673 EP E679 DI 10.1016/j.ijrobp.2011.04.036 PG 7 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300063 PM 21669503 ER PT J AU Oh, KS Hung, J Robertson, PL Garton, HJ Muraszko, KM Sandler, HM Hamstra, DA AF Oh, Kevin S. Hung, Jonathan Robertson, Patricia L. Garton, Hugh J. Muraszko, Karin M. Sandler, Howard M. Hamstra, Daniel A. TI OUTCOMES OF MULTIDISCIPLINARY MANAGEMENT IN PEDIATRIC LOW-GRADE GLIOMAS SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article; Proceedings Paper CT 50th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology (ASTRO) CY SEP 21-25, 2008 CL Boston, MA SP Amer Soc Therapeut Radiol & Oncol (ASTRO) DE Glioma; Low-grade; Pediatric; Radiation; Surgery ID CONFORMAL RADIATION-THERAPY; OPTIC PATHWAY; PROGNOSTIC FACTORS; PRIMARY TUMORS; FOLLOW-UP; CHILDREN; ASTROCYTOMAS; NEUROFIBROMATOSIS; CHILDHOOD; CHEMOTHERAPY AB Purpose: To evaluate the outcomes in pediatric low-grade gliomas managed in a multidisciplinary setting. Methods and Materials: We conducted a single-institution retrospective study of 181 children with Grade I-II gliomas. Log-rank and stepwise Cox proportional hazards models were used to analyze freedom from progression (FFP) and overall survival (OS). Results: Median follow-up was 6.4 years. Thirty-four (19%) of patients had neurofibromatosis Type 1 (NF1) and because of their favorable prognosis were evaluated separately. In the 147 (81%) of patients without NF1, actuarial 7-year FFP and OS were 67 +/- 4% (standard error) and 94 +/- 2%, respectively. In this population, tumor location in the optic pathway/hypothalamus was associated with worse FFP (39% vs. 76%, p < 0.0003), but there was no difference in OS. Age <= 5 years was associated with worse FFP (52% vs. 75%, p < 0.02) but improved OS (97% vs. 92%, p < 0.05). In those with tissue diagnosis, gross total resection (GTR) was associated with improved 7-year FFP (81% vs. 56%, p < 0.02) and OS (100% vs. 90%, p < 0.03). In a multivariate model, only location in the optic pathway/hypothalamus predicted worse FFP (p < 0.01). Fifty patients received radiation therapy (RT). For those with less than GTR, adjuvant RT improved FFP (89% vs. 49%, p < 0.003) but not OS. There was no difference in OS between patient groups given RT as adjuvant vs. salvage therapy. In NF1 patients, 94% of tumors were located in the optic pathway/hypothalamus. With a conservative treatment strategy in this population, actuarial 7-year FFP and OS were 73 +/- 9% and 100%, respectively. Conclusions: Low-grade gliomas in children <= 5 years old with tumors in the optic pathway/hypothalamus are more likely to progress, but this does not confer worse OS because of the success of salvage therapy. When GTR is not achieved, adjuvant RT improves FFP but not OS. Routine adjuvant RT can be avoided and instead reserved as salvage. (C) 2011 Elsevier Inc. C1 [Oh, Kevin S.; Hung, Jonathan; Sandler, Howard M.] Univ Michigan Hlth Syst, Dept Radiat Oncol, Ann Arbor, MI USA. [Robertson, Patricia L.; Hamstra, Daniel A.] Univ Michigan Hlth Syst, Dept Pediat & Communicable Dis, Ann Arbor, MI USA. [Robertson, Patricia L.; Hamstra, Daniel A.] Univ Michigan Hlth Syst, Dept Neurol, Ann Arbor, MI USA. [Garton, Hugh J.; Muraszko, Karin M.] Univ Michigan Hlth Syst, Dept Neurosurg, Ann Arbor, MI USA. RP Oh, KS (reprint author), Massachusetts Gen Hosp, Dept Radiat Oncol, 100 Blossom St,Cox 3, Boston, MA 02114 USA. EM koh2@partners.org NR 34 TC 11 Z9 11 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E481 EP E488 DI 10.1016/j.ijrobp.2011.01.019 PG 8 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300037 PM 21470783 ER PT J AU Sher, DJ Neville, BA Chen, AB Schrag, D AF Sher, David J. Neville, Bridget A. Chen, Aileen B. Schrag, Deborah TI PREDICTORS OF IMRT AND CONFORMAL RADIOTHERAPY USE IN HEAD AND NECK SQUAMOUS CELL CARCINOMA: A SEER-MEDICARE ANALYSIS SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Head and neck cancer; IMRT; Patterns of care; Health services research ID INTENSITY-MODULATED RADIOTHERAPY; QUALITY-OF-LIFE; PAROTID-GLAND; RADIATION-THERAPY; PROCEDURE VOLUME; RECTAL-CANCER; OUTCOMES; NASOPHARYNX; IRRADIATION; SURGEON AB Purpose: The extent to which new techniques for the delivery of radiotherapy for head and neck squamous cell carcinoma (HNSCC) have diffused into clinical practice is unclear, including the use of 3-dimensional conformal RT (3D-RT) and intensity-modulated radiation therapy (IMRT). Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database, we identified 2,495 Medicare patients with Stage I-IVB HNSCC diagnosed at age 65 years or older between 2000 and 2005 and treated with either definitive (80%) or adjuvant (20%) radiotherapy. Our primary aim was to analyze the trends and predictors of IMRT use over this time, and the secondary aim was a similar description of the trends and predictors of conformal radiotherapy (CRT) use, defined as treatment with either 3D-RTor IMRT. Results: Three hundred sixty-four (15%) patients were treated with IMRT, and 1,190 patients (48%) were treated with 3D-RT. Claims for IMRT and CRT rose from 0% to 33% and 39% to 86%, respectively, between 2000 and 2005. On multivariable analysis, IMRT use was associated with SEER region (West 18%; Northeast 11%; South 12%; Midwest 13%), advanced stage (advanced, 21%; early, 9%), non-larynx site (non-larynx, 23%; larynx, 7%), higher median census tract income (highest vs. lowest quartile, 18% vs. 10%), treatment year (2003-2005, 31%; 2000-2002, 6%), use of chemotherapy (26% with; 9% without), and higher radiation oncologist treatment volume (highest vs. lowest tertile, 23% vs. 8%). With CRT as the outcome, only SEER region, treatment year, use of chemotherapy, and increasing radiation oncologist HNSCC volume were significant on multivariable analysis. Conclusions: The use of IMRT and CRT by Medicare beneficiaries with HNSCC rose significantly between 2000 and 2005 and was associated with both clinical and non-clinical factors, with treatment era and radiation oncologist HNSCC treatment volume serving as the strongest predictors of IMRT use. (C) 2011 Elsevier Inc. C1 [Sher, David J.; Chen, Aileen B.] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA. [Sher, David J.; Chen, Aileen B.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Sher, David J.; Neville, Bridget A.; Chen, Aileen B.; Schrag, Deborah] Dana Farber Canc Inst, Ctr Outcomes & Policy Res, Boston, MA 02115 USA. RP Sher, DJ (reprint author), Dana Farber Canc Inst, Dept Radiat Oncol, 44 Binney St, Boston, MA 02115 USA. EM dsher@lroc.harvard.edu OI Chen, Aileen/0000-0002-5385-3360 NR 26 TC 16 Z9 16 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E197 EP E206 DI 10.1016/j.ijrobp.2011.02.007 PG 10 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300001 PM 21596483 ER PT J AU Sher, DJ Thotakura, V Balboni, TA Norris, CM Haddad, RI Posner, MR Lorch, J Goguen, LA Annino, DJ Tishler, RB AF Sher, David J. Thotakura, Vijaya Balboni, Tracy A. Norris, Charles M., Jr. Haddad, Robert I. Posner, Marshall R. Lorch, Jochen Goguen, Laura A. Annino, Donald J. Tishler, Roy B. TI TREATMENT OF ORAL CAVITY SQUAMOUS CELL CARCINOMA WITH ADJUVANT OR DEFINITIVE INTENSITY-MODULATED RADIATION THERAPY SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Combined modality therapy; Head and neck cancer; IMRT; Oral cavity ID NECK-CANCER; RADIOTHERAPY; HEAD; CHEMOTHERAPY; FAILURE; IMRT AB Purpose: The optimal management of oral cavity squamous cell carcinoma (OCSCC) typically involves surgical resection followed by adjuvant radiotherapy or chemoradiotherapy (CRT) in the setting of adverse pathologic features. Intensity-modulated radiation therapy (IMRT) is frequently used to treat oral cavity cancers, but published IMRToutcomes specific to this disease site are sparse. We report the Dana-Farber Cancer Institute experience with IMRT-based treatment for OCSCC. Methods and Materials: Retrospective study of all patients treated at Dana-Farber Cancer Institute for OCSCC with adjuvant or definitive IMRT between August 2004 and December 2009. The American Joint Committee on Cancer disease stage criteria distribution of this cohort included 5 patients (12%) with stage I; 10 patients (24%) with stage II (n = 10, 24%),; 14 patients (33%) with stage III (n = 14, 33%),; and 13 patients (31%) with stage IV. The primary endpoint was overall survival (OS); secondary endpoints were locoregional control (LRC) and acute and chronic toxicity. Results: Forty-two patients with OCSCC were included, 30 of whom were initially treated with surgical resection. Twenty-three (77%) of 30 surgical patients treated with adjuvant IMRT also received concurrent chemotherapy, and 9 of 12 (75%) patients treated definitively without surgery were treated with CRT or induction chemotherapy and CRT. With a median follow-up of 2.1 years (interquartile range, 1.1-3.1 years) for all patients, the 2-year actuarial rates of OS and LRC following adjuvant IMRT were 85% and 91%, respectively, and the comparable results for definitive IMRT were 63% and 64% for OS and LRC, respectively. Only 1 patient developed symptomatic osteoradionecrosis, and among patients without evidence of disease, 35% experienced grade 2 to 3 late dysphagia, with only 1 patient who was continuously gastrostomy-dependent. Conclusions: In this single-institution series, postoperative IMRT was associated with promising LRC, OS, and lower late toxicity rates, and chemoradiotherapy was a successful treatment for patients with high-risk disease. In contrast, outcomes of radiation-based treatment for patients with inoperable locally advanced disease were markedly less successful. (C) 2011 Elsevier Inc. C1 [Sher, David J.; Balboni, Tracy A.; Tishler, Roy B.] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA. [Thotakura, Vijaya; Norris, Charles M., Jr.; Haddad, Robert I.; Posner, Marshall R.; Lorch, Jochen] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Thotakura, Vijaya; Norris, Charles M., Jr.; Haddad, Robert I.; Posner, Marshall R.; Lorch, Jochen] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Goguen, Laura A.; Annino, Donald J.] Brigham & Womens Hosp, Dept Surg, Div Otolaryngol, Boston, MA 02115 USA. RP Sher, DJ (reprint author), Dana Farber Canc Inst, Dept Radiat Oncol, 44 Binney St, Boston, MA 02115 USA. EM dsher@lroc.harvard.edu NR 15 TC 19 Z9 19 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E215 EP E222 DI 10.1016/j.ijrobp.2011.02.023 PG 8 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300003 PM 21531515 ER PT J AU Wang, D Bosch, W Roberge, D Finkelstein, SE Petersen, I Haddock, M Chen, YLE Saito, NG Kirsch, DG Hitchcock, YJ Wolfson, AH DeLaney, TF AF Wang, Dian Bosch, Walter Roberge, David Finkelstein, Steven E. Petersen, Ivy Haddock, Michael Chen, Yen-Lin E. Saito, Naoyuki G. Kirsch, David G. Hitchcock, Ying J. Wolfson, Aaron H. DeLaney, Thomas F. TI RTOG SARCOMA RADIATION ONCOLOGISTS REACH CONSENSUS ON GROSS TUMOR VOLUME AND CLINICAL TARGET VOLUME ON COMPUTED TOMOGRAPHIC IMAGES FOR PREOPERATIVE RADIOTHERAPY OF PRIMARY SOFT TISSUE SARCOMA OF EXTREMITY IN RADIATION THERAPY ONCOLOGY GROUP STUDIES SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article; Proceedings Paper CT 16th Annual Meeting of the Connective-Tissue-Oncology-Society CY NOV 11-13, 2010 CL Paris, FRANCE SP Connect Tissue Oncol Soc DE Sarcoma; Target definition; Radiotherapy ID POSTOPERATIVE RADIOTHERAPY AB Objective: To develop a Radiation Therapy Oncology Group (RTOG) atlas delineating gross tumor volume (GTV) and clinical target volume (CTV) to be used for preoperative radiotherapy of primary extremity soft tissue sarcoma (STS). Methods and Materials: A consensus meeting was held during the RTOG meeting in January 2010 to reach agreement about GTV and CTV delineation on computed tomography (CT) images for preoperative radiotherapy of high-grade large extremity STS. Data were presented to address the local extension of STS. Extensive discussion ensued to develop optimal criteria for GTV and CTV delineation on CT images. Results: A consensus was reached on appropriate CT-based GTV and CTV. The GTV is gross tumor defined by T1 contrast-enhanced magnetic resonance images. Fusion of magnetic resonance and images is recommended to delineate the GTV. The CTV for high-grade large STS typically includes the GTV plus 3-cm margins in the longitudinal directions. If this causes the field to extend beyond the compartment, the field can be shortened to include the end of a compartment. The radial margin from the lesion should be 1.5 cm, including any portion of the tumor not confined by an intact fascial barrier, bone, or skin surface. Conclusion: The consensus on GTV and CTV for preoperative radiotherapy of high-grade large extremity STS is available as web-based images and in a descriptive format through the RTOG. This is expected to improve target volume consistency and allow for rigorous evaluation of the benefits and risks of such treatment. (C) 2011 Elsevier Inc. C1 [Wang, Dian] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53045 USA. [Bosch, Walter] Washington Univ, St Louis, MO USA. [Roberge, David] McGill Univ, Montreal, PQ, Canada. [Petersen, Ivy; Haddock, Michael] Mayo Clin, Rochester, MN USA. [Finkelstein, Steven E.] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [DeLaney, Thomas F.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Chen, Yen-Lin E.; Saito, Naoyuki G.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Kirsch, David G.] Duke Univ, Durham, NC USA. [Hitchcock, Ying J.] Univ Utah, Salt Lake City, UT USA. [Wolfson, Aaron H.] Univ Miami, Miller Sch Med, Miami, FL USA. RP Wang, D (reprint author), Med Coll Wisconsin, Dept Radiat Oncol, 8701 Watertown Plank Rd, Milwaukee, WI 53045 USA. EM dwang@mcw.edu FU NCI NIH HHS [U24CA81647, U10 CA021661-24, U10 CA021661-24S1, U10 CA021661-26, U10 CA021661-27S2, U10 CA021661-28, U10 CA021661-28S1, U10 CA021661-31, U10 CA021661-31S1, U10 CA021661-32S2, U10 CA021661-32S4, U10 CA021661-33, U10 CA021661-33S1, U10 CA021661-34S2, U10 CA021661-35, U24 CA081647, U10 CA021661, U10 CA021661-27, U10 CA021661-25, U10 CA021661-27S1, U10 CA021661-29, U10 CA021661-30, U10 CA021661-32, U10 CA021661-32S1, U10 CA021661-32S3, U10 CA021661-33S2, U10 CA021661-34, U10 CA021661-34S1, U10 CA021661-36, U10CA21661] NR 15 TC 20 Z9 21 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E525 EP E528 DI 10.1016/j.ijrobp.2011.04.038 PG 4 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300043 PM 21676552 ER PT J AU Winkfield, KM Chen, MH Dosoretz, DE Salenius, SA Katin, M Ross, R D'Amico, AV AF Winkfield, Karen M. Chen, Ming-Hui Dosoretz, Daniel E. Salenius, Sharon A. Katin, Michael Ross, Rudi D'Amico, Anthony V. TI RACE AND SURVIVAL FOLLOWING BRACHYTHERAPY-BASED TREATMENT FOR MEN WITH LOCALIZED OR LOCALLY ADVANCED ADENOCARCINOMA OF THE PROSTATE SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Cardiac comorbidity; Prostate brachytherapy; Prostate cancer; Racial disparities; Treatment outcomes ID CORONARY-ARTERY-DISEASE; RADICAL PROSTATECTOMY; SOCIOECONOMIC-STATUS; RACIAL-DIFFERENCES; RADIATION-THERAPY; AFRICAN-AMERICAN; WHITE MEN; ALL-CAUSE; CANCER; MORTALITY AB Purpose: We investigated whether race was associated with risk of death following brachytherapy-based treatment for localized prostate cancer, adjusting for age, cardiovascular comorbidity, treatment, and established prostate cancer prognostic factors. Methods: The study cohort was composed of 5,360 men with clinical stage T1-3N0M0 prostate cancer who underwent brachytherapy-based treatment at 20 centers within the 21st Century Oncology consortium. Cox regression multivariable analysis was used to evaluate the risk of death in African-American and Hispanic men compared to that in Caucasian men, adjusting for age, pretreatment prostate-specific antigen (PSA) level, Gleason score, clinical T stage, year and type of treatment, median income, and cardiovascular comorbidities. Results: After a median follow-up of 3 years, there were 673 deaths. African-American and Hispanic races were significantly associated with an increased risk of all-cause mortality (ACM) (adjusted hazard ratio, 1.77 and 1.79; 95% confidence intervals, 1.3-2.5 and 1.2-2.7; p < 0.001 and p = 0.005, respectively). Other factors significantly associated with an increased risk of death included age (p < 0.001), Gleason score of 8 to 10 (p = 0.04), year of brachytherapy (p < 0.001), and history of myocardial infarction treated with stent or coronary artery bypass graft (p < 0.001). Conclusions: After adjustment for prostate cancer prognostic factors, age, income level, and revascularized cardiovascular comorbidities, African-American and Hispanic races were associated with higher ACM in men with prostate cancer. Additional causative factors need to be identified. (C) 2011 Elsevier Inc. C1 [Winkfield, Karen M.] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. [Winkfield, Karen M.] Harvard Univ, Sch Med, Harvard Radiat Oncol Program, Boston, MA USA. [Chen, Ming-Hui] Univ Connecticut, Dept Stat, Storrs, CT 06269 USA. [Dosoretz, Daniel E.; Salenius, Sharon A.; Katin, Michael; Ross, Rudi] 21st Century Oncol Inc, Ft Myers, FL USA. [D'Amico, Anthony V.] Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA. RP Winkfield, KM (reprint author), Massachusetts Gen Hosp, Dept Radiat Oncol, 100 Blossom St,Cox 3, Boston, MA 02114 USA. EM kwinkfield@partners.org NR 39 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP E345 EP E350 DI 10.1016/j.ijrobp.2011.02.022 PG 6 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 014YQ UT WOS:000309412300019 PM 21514066 ER PT J AU Harkness, JR Morrow, DA Braunwald, E Ren, F Lopez-Sendon, J Bode, C Budaj, A Scirica, BM AF Harkness, James R. Morrow, David A. Braunwald, Eugene Ren, Fang Lopez-Sendon, J. Bode, Christopher Budaj, Andrzej Scirica, Benjamin M. TI Myocardial Ischemia and Ventricular Tachycardia on Continuous Electrocardiographic Monitoring and Risk of Cardiovascular Outcomes After Non-ST-Segment Elevation Acute Coronary Syndrome (from the MERLIN-TIMI 36 Trial) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID SYNDROME-THROMBOLYSIS; METABOLIC EFFICIENCY; UNSTABLE ANGINA; LESS ISCHEMIA; INFARCTION; RANOLAZINE; DEFIBRILLATOR; PREVALENCE; EVENTS; MARKER AB Among patients with non-ST-segment elevation acute coronary syndromes, recurrent ischemia and ventricular arrhythmias detected on continuous electrocardiographic monitoring remain common events that are associated with worse outcomes. The relative clinical significance of both events together is not well described. We determined the risk associated with ischemia (>= 1 mm ST depression lasting >= 1 minutes) and ventricular tachycardia (VT) (>= 4 beats) detected on 7-day continuous electrocardiographic monitoring in 6,355 patients with non-ST-segment elevation acute coronary syndromes from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-elevation Acute Coronary Syndrome Thrombolysis In Myocardial Infarction (MERLIN-TIMI) 36 trial. The patients were categorized into 4 groups according to the presence or absence of VT and ischemia. Cardiovascular death, sudden cardiac death (SCD), myocardial infarction, and recurrent ischemia were assessed during a median follow-up of 348 days. A total of 60.0% patients had no VT or ischemia, 20.0% had VT alone, 14.7% had ischemia alone, and 5.3% had both. The patients with either VT or ischemia were at increased risk of cardiovascular outcomes. The combination of ischemia and VT identified a particularly high-risk population for cardiovascular death (10.1% vs 3.0%, p <0.001), SCD (7.8% vs 0.9%, p <0.001), and myocardial infarction (15.4% vs 6.2%, p <0.001) compared to patients with neither. The addition of arrhythmia and ischemia significantly improved the clinical model for predicting cardiovascular death or SCD (p <0.001). In patients with both ischemia and VT, 66.6% of SCD occurred within 90 days of the non-ST-segment elevation acute coronary syndromes. In conclusion, in >6,300 patients with non-ST-segment elevation acute coronary syndromes, the presence of myocardial ischemia or VT alone, and particularly in combination, was independently associated with poor cardiovascular outcomes and thus provides incremental improvement in early risk stratification. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;108:1373-1381) C1 [Harkness, James R.; Morrow, David A.; Braunwald, Eugene; Ren, Fang; Scirica, Benjamin M.] TIMI Study Grp, Boston, MA USA. [Harkness, James R.] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. [Morrow, David A.; Braunwald, Eugene; Ren, Fang; Scirica, Benjamin M.] Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA. [Morrow, David A.; Braunwald, Eugene; Ren, Fang; Scirica, Benjamin M.] Harvard Univ, Sch Med, Boston, MA USA. [Lopez-Sendon, J.] Hosp Univ La Paz, Madrid, Spain. [Bode, Christopher] Med Univ Klin, Freiburg, Germany. [Budaj, Andrzej] Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland. RP Scirica, BM (reprint author), TIMI Study Grp, Boston, MA USA. EM bscirica@partners.org FU Michael Lerner Foundation; Gilead Sciences, Foster City, California; Daiichi-Sankyo, Parsipanny, New Jersey; Novartis FX Dr. Scirica has served as a consultant for Lexicon Pharmaceutical, The Woodlands, Texas, Arena Pharmaceuticals, San Diego, California, Gilead Sciences, Foster City, California, and Shionegi, Florham Park, New Jersey; and is the recipient of an unrestricted research grant from the Michael Lerner Foundation and research funding from Gilead Sciences, Foster City, California, and Daiichi-Sankyo, Parsipanny, New Jersey. Dr. Morrow has received honoraria for educational presentations from CV Therapeutics and Sanofi-Aventis, Bridgewater, New Jersey, serving as a consultant for GlaxoSmithKline, Philadelphia, Pennsylvania, and Sanofi-Aventis, and being on an advisory board for Genentech, San Francisco, California. Dr. Budaj receives honoraria from CV Therapeutics, AstraZeneca Wilmington, Delaware, GlaxoSmithKline, Boehringer Ingelheim, Ingelheim am Rhein, Germany, and Sanofi-Aventis and serves as a consultant to GlaxoSmithKline and Sanofi-Aventis. Dr. Lopez-Sendon has received research grants from Novartis. NR 18 TC 4 Z9 6 U1 0 U2 3 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD NOV 15 PY 2011 VL 108 IS 10 BP 1373 EP 1381 DI 10.1016/j.amjcard.2011.06.058 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 853OH UT WOS:000297435100001 PM 21890090 ER PT J AU Tschop, K Dyson, N AF Tschoep, Katrin Dyson, Nicholas TI Identifying players in the functional network around pRB SO CELL CYCLE LA English DT Editorial Material ID RETINOBLASTOMA PROTEIN; HUMAN CANCER; RB; SUPPRESSION C1 [Tschoep, Katrin; Dyson, Nicholas] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Charlestown, MA USA. RP Dyson, N (reprint author), Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Charlestown, MA USA. EM dyson@helix.mgh.harvard.edu NR 11 TC 0 Z9 0 U1 0 U2 0 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1538-4101 J9 CELL CYCLE JI Cell Cycle PD NOV 15 PY 2011 VL 10 IS 22 BP 3814 EP 3815 DI 10.4161/cc.10.22.18225 PG 2 WC Cell Biology SC Cell Biology GA 850BE UT WOS:000297168600007 PM 22142859 ER PT J AU Zhu, AX Abrams, TA Miksad, R Blaszkowsky, LS Meyerhardt, JA Zheng, H Muzikansky, A Clark, JW Kwak, EL Schrag, D Jors, KR Fuchs, CS Iafrate, AJ Borger, DR Ryan, DP AF Zhu, Andrew X. Abrams, Thomas A. Miksad, Rebecca Blaszkowsky, Lawrence S. Meyerhardt, Jeffrey A. Zheng, Hui Muzikansky, Alona Clark, Jeffrey W. Kwak, Eunice L. Schrag, Deborah Jors, Kathryn R. Fuchs, Charles S. Iafrate, A. John Borger, Darrell R. Ryan, David P. TI Phase 1/2 Study of Everolimus in Advanced Hepatocellular Carcinoma SO CANCER LA English DT Article DE hepatocellular carcinoma; everolimus; mTOR inhibitors; angiogenesis; clinical trial ID ADVANCED SOLID TUMORS; MAMMALIAN TARGET; MTOR INHIBITION; RAPAMYCIN; CANCER; AKT; SORAFENIB; UPSTREAM; PATHWAY; CASCADE AB BACKGROUND: The phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway plays a critical role in the pathogenesis of hepatocellular carcinoma (HCC). We performed a single-arm, phase 1/2 study of everolimus in patients with advanced HCC. METHODS: Patients with histologically confirmed measurable advanced HCC, 0-2 prior regimens, and adequate hematologic, hepatic, and renal functions received everolimus at 5 mg/day or 10 mg/day orally (6 weeks/cycle). The primary end points were determination of a safe dosage of everolimus (phase 1) and progression-free survival (PFS) at 24 weeks (phase 2). RESULTS: Twenty-eight patients were enrolled and evaluable for efficacy and toxicity. No dose-limiting toxicities were observed at the 5 mg/day (n = 3) or 10 mg/day (n = 6) dosage level in phase 1. Twenty-five patients received everolimus at 10 mg/day. Grade 3-4 adverse events included lymphopenia (n = 3), aspartate transaminase (n = 3), hyponatremia (n = 2), and 1 patient each with anemia, alanine transaminase, hyperglycemia, proteinuria, rash, and hypoxia. One patient (4%) had partial response (95% confidence interval [CI], 0.9%-19.6%). The median PFS and overall survival were 3.8 months (95% CI, 2.1-4.6) and 8.4 months (95% CI, 3.9-21.1), respectively. The estimated PFS rate at 24 weeks was 28.6% (95% CI, 7.9%-49.3%). CONCLUSION: Everolimus was well tolerated in patients with advanced HCC, and 10 mg/day was defined as the phase 2 dosage. Although the study did not proceed to the second stage of phase 2, preliminary antitumor activity was observed with everolimus in patients with advanced HCC, most of whom had prior systemic treatment. Cancer 2011;117:5094-102. (C) 2011 American Cancer Society. C1 [Zhu, Andrew X.; Blaszkowsky, Lawrence S.; Zheng, Hui; Muzikansky, Alona; Clark, Jeffrey W.; Kwak, Eunice L.; Jors, Kathryn R.; Iafrate, A. John; Borger, Darrell R.; Ryan, David P.] Harvard Univ, Ctr Canc, Massachusetts Gen Hosp, Sch Med, Boston, MA 02114 USA. [Abrams, Thomas A.; Meyerhardt, Jeffrey A.; Schrag, Deborah; Fuchs, Charles S.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02114 USA. [Miksad, Rebecca] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02114 USA. RP Zhu, AX (reprint author), Harvard Univ, Ctr Canc, Massachusetts Gen Hosp, Sch Med, 55 Fruit St,LH POB 232, Boston, MA 02114 USA. EM azhu@partners.org OI Miksad, Rebecca/0000-0003-3194-5122 FU Novartis FX This study was supported by Novartis. NR 24 TC 103 Z9 108 U1 0 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD NOV 15 PY 2011 VL 117 IS 22 BP 5094 EP 5102 DI 10.1002/cncr.26165 PG 9 WC Oncology SC Oncology GA 847JN UT WOS:000296969300010 PM 21538343 ER PT J AU Mansour, MR Look, AT AF Mansour, Marc R. Look, A. Thomas TI Discovery of a Secreted Tumor Suppressor Provides a Promising Therapeutic Strategy for Follicular Lymphoma SO CANCER CELL LA English DT Editorial Material ID EPH-RECEPTOR; CANCER AB In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-eleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 signaling, and, as a secreted tumor suppressor protein, has potential as a targeted therapeutic polypeptide. C1 [Mansour, Marc R.; Look, A. Thomas] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Mansour, Marc R.; Look, A. Thomas] Childrens Hosp, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA. [Mansour, Marc R.] UCL Canc Inst, Dept Haematol, London WC1E 6BT, England. RP Look, AT (reprint author), Childrens Hosp, Dana Farber Canc Inst, Dept Pediat Oncol, 450 Brookline Ave, Boston, MA 02115 USA. EM thomas_look@dfci.harvard.edu NR 9 TC 1 Z9 1 U1 0 U2 4 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1535-6108 J9 CANCER CELL JI Cancer Cell PD NOV 15 PY 2011 VL 20 IS 5 BP 559 EP 561 DI 10.1016/j.ccr.2011.10.027 PG 3 WC Oncology; Cell Biology SC Oncology; Cell Biology GA 848WQ UT WOS:000297086200005 PM 22094251 ER PT J AU Anders, L Ke, N Hydbring, P Choi, YJ Widlund, HR Chick, JM Zhai, HL Vidal, M Gygi, SP Braun, P Sicinski, P AF Anders, Lars Ke, Nan Hydbring, Per Choi, Yoon J. Widlund, Hans R. Chick, Joel M. Zhai, Huili Vidal, Marc Gygi, Stephen P. Braun, Pascal Sicinski, Piotr TI A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells SO CANCER CELL LA English DT Article ID TRANSCRIPTION FACTOR FOXM1C; CELLULAR SENESCENCE; BREAST-CANCER; TUMOR-SUPPRESSOR; CYCLIN; PROGRESSION; INHIBITION; TRANSITION; MECHANISMS; MELANOMA AB Cyclin D-dependent kinases (CDK4 and CDK6) are positive regulators of cell cycle entry and they are over-active in the majority of human cancers. However, it is currently not completely understood by which cellular mechanisms CDK4/6 promote tumorigenesis, largely due to the limited number of identified substrates. Here we performed a systematic screen for substrates of cyclin D1-CDK4 and cyclin D3-CDK6. We identified the Forkhead Box M1 (FOXM1) transcription factor as a common critical phosphorylation target. CDK4/6 stabilize and activate FOXM1, thereby maintain expression of G1/S phase genes, suppress the levels of reactive oxygen species (ROS), and protect cancer cells from senescence. Melanoma cells, unlike melanocytes, are highly reliant on CDK4/6-mediated senescence suppression, which makes them particularly susceptible to CDK4/6 inhibition. C1 [Anders, Lars; Ke, Nan; Hydbring, Per; Choi, Yoon J.; Vidal, Marc; Braun, Pascal; Sicinski, Piotr] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA. [Vidal, Marc; Braun, Pascal] Dana Farber Canc Inst, CCSB, Boston, MA 02215 USA. [Anders, Lars; Ke, Nan; Hydbring, Per; Choi, Yoon J.; Vidal, Marc; Braun, Pascal; Sicinski, Piotr] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [Chick, Joel M.; Gygi, Stephen P.] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA. [Widlund, Hans R.] Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA. [Zhai, Huili] Novartis Inst Biomed Res, Cambridge, MA 02139 USA. RP Anders, L (reprint author), Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA. EM lars.anders.hms@gmail.com; peter_sicinski@dfci.harvard.edu RI Braun, Pascal/B-9669-2013 OI Braun, Pascal/0000-0003-2012-6746 FU Swedish Wenner-Gren Foundations; NIH [R01 CA083688, RL1 DE019022]; Susan G. Komen for the Cure; Ellison Foundation, Boston; DFCI Strategic Initiative; CCSB FX We thank Drs. Rene Medema for providing FOXM1 plasmids, IGFBP-1, 6DB. CENPF, and PLK1 promoter sequences and FOXM1 knockout MEFs; David Fruman and Richard Assoian for CCNG2 and SKP2 promoters, Reuven Agami for pSUPER-CDH1. Sunkyu Kim and Nina Ilic for cell lines. We also thank Philippe Lamesch, Kourosh Salehi-Ashtiani, and Josh LaBaer for help with the ORFeome libraries. P.H. was supported by a fellowship from the Swedish Wenner-Gren Foundations. This work was supported by NIH Grant R01 CA083688 to P.S. and RL1 DE019022 to S.P.G., a grant from Susan G. Komen for the Cure to P.S., a grant from the Ellison Foundation, Boston to M.V., and in part by Institute-Sponsored Research funds from the DFCI Strategic Initiative in support of CCSB. M.V. is a Chercheur Qualifie Honoraire from the Fonds de la Recherche Scientifique (FRS-FNRS, French Community of Belgium). NR 36 TC 125 Z9 127 U1 2 U2 25 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1535-6108 J9 CANCER CELL JI Cancer Cell PD NOV 15 PY 2011 VL 20 IS 5 BP 620 EP 634 DI 10.1016/j.ccr.2011.10.001 PG 15 WC Oncology; Cell Biology SC Oncology; Cell Biology GA 848WQ UT WOS:000297086200010 PM 22094256 ER PT J AU Hackam, DG Woodward, M Newby, LK Bhatt, DL Shao, MY Smith, EE Donner, A Mamdani, M Douketis, JD Arima, H Chalmers, J MacMahon, S Tirschwell, DL Psaty, BM Bushnell, CD Aguilar, MI Capampangan, DJ Werring, DJ De Rango, P Viswanathan, A Danchin, N Cheng, CL Yang, YHK Verdel, BM Lai, MS Kennedy, J Uchiyama, S Yamaguchi, T Ikeda, Y Mrkobrada, M AF Hackam, Daniel G. Woodward, Mark Newby, L. Kristin Bhatt, Deepak L. Shao, Mingyuan Smith, Eric E. Donner, Allan Mamdani, Muhammad Douketis, James D. Arima, Hisatomi Chalmers, John MacMahon, Stephen Tirschwell, David L. Psaty, Bruce M. Bushnell, Cheryl D. Aguilar, Maria I. Capampangan, Dan J. Werring, David J. De Rango, Paola Viswanathan, Anand Danchin, Nicolas Cheng, Ching-Lan Yang, Yea-Huei Kao Verdel, B. Marianne Lai, Mei-Shu Kennedy, James Uchiyama, Shinichiro Yamaguchi, Takenori Ikeda, Yasuo Mrkobrada, Marko TI Statins and Intracerebral Hemorrhage Collaborative Systematic Review and Meta-Analysis SO CIRCULATION LA English DT Review DE cerebrovascular disorders; hemorrhage; meta-analysis; statins ID CORONARY-HEART-DISEASE; BASE-LINE CHARACTERISTICS; RANDOMIZED CONTROLLED-TRIAL; ACUTE MYOCARDIAL-INFARCTION; PLACEBO-CONTROLLED TRIAL; SCANDINAVIAN SIMVASTATIN SURVIVAL; DENSITY-LIPOPROTEIN CHOLESTEROL; GLYCOPROTEIN IIB/IIIA RECEPTOR; ESTROGEN-PROGESTIN REPLACEMENT; RENAL-TRANSPLANT RECIPIENTS AB Background-A recent large, randomized trial suggested that statins may increase the risk of intracerebral hemorrhage. Accordingly, we systematically reviewed the association of statins with intracerebral hemorrhage in randomized and observational data. Methods and Results-We screened 17 electronic bibliographic databases to identify eligible studies and consulted with experts in the field. We used DerSimonian-Laird random-effects models to compute summary risk ratios with 95% confidence intervals. Randomized trials, cohort studies, and case-control studies were analyzed separately. Only adjusted risk estimates were used for pooling observational data. We included published and unpublished data from 23 randomized trials and 19 observational studies. The complete data set comprised 248 391 patients and 14 784 intracerebral hemorrhages. Statins were not associated with an increased risk of intracerebral hemorrhage in randomized trials (risk ratio, 1.10; 95% confidence interval, 0.86-1.41), cohort studies (risk ratio, 0.94; 95% confidence interval, 0.81-1.10), or case-control studies (risk ratio, 0.60; 95% confidence interval, 0.41-0.88). Substantial statistical heterogeneity was evident for the case-control studies (I-2=66%, P=0.01), but not for the cohort studies (I-2=0%, P=0.48) or randomized trials (I-2=30%, P=0.09). Sensitivity analyses by study design features, patient characteristics, or magnitude of cholesterol lowering did not materially alter the results. Conclusions-We found no evidence that statins were associated with intracerebral hemorrhage; if such a risk is present, its absolute magnitude is likely to be small and outweighed by the other cardiovascular benefits of these drugs. (Circulation. 2011;124:2233-2242.) C1 [Hackam, Daniel G.; Donner, Allan; Mrkobrada, Marko] Univ Western Ontario, London, ON, Canada. [Woodward, Mark; Arima, Hisatomi; Chalmers, John; MacMahon, Stephen] Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, Australia. [Newby, L. Kristin] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA. [Bhatt, Deepak L.] Brigham & Womens Hosp, VA Boston Healthcare Syst, Boston, MA 02115 USA. [Bhatt, Deepak L.; Viswanathan, Anand] Harvard Univ, Sch Med, Boston, MA USA. [Shao, Mingyuan] Cleveland Clin, Cleveland, OH 44106 USA. [Smith, Eric E.] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada. [Mamdani, Muhammad] Univ Toronto, Appl Hlth Res Ctr, Toronto, ON, Canada. [Douketis, James D.] McMaster Univ, Hamilton, ON, Canada. [Tirschwell, David L.; Psaty, Bruce M.] Univ Washington, Seattle, WA 98195 USA. [Bushnell, Cheryl D.] Wake Forest Baptist Med Ctr, Winston Salem, NC USA. [Aguilar, Maria I.; Capampangan, Dan J.] Mayo Clin, Scottsdale, AZ USA. [Werring, David J.] UCL Inst Neurol, London, England. [De Rango, Paola] Univ Perugia, Hosp SM Misericordia, I-06100 Perugia, Italy. [Viswanathan, Anand] Massachusetts Gen Hosp, Ctr Stroke Res, Boston, MA 02114 USA. [Danchin, Nicolas] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, Paris, France. [Cheng, Ching-Lan; Yang, Yea-Huei Kao] Natl Cheng Kung Univ, Tainan 70101, Taiwan. [Verdel, B. Marianne] Univ Utrecht, Utrecht, Netherlands. [Lai, Mei-Shu] Natl Taiwan Univ, Taipei 10764, Taiwan. [Kennedy, James] Univ Oxford, John Radcliffe Hosp, Oxford OX1 2JD, Oxon, England. [Uchiyama, Shinichiro] Tokyo Womens Med Univ, Tokyo, Japan. [Yamaguchi, Takenori] Natl Cardiovasc Ctr, Suita, Osaka 565, Japan. [Ikeda, Yasuo] Waseda Univ, Tokyo, Japan. RP Hackam, DG (reprint author), SPARC, Siebens Drake Res Inst, Room 100K-2,1400 Western Rd, London, ON N6G 2V2, Canada. EM dhackam@uwo.ca RI Woodward, Mark/D-8492-2015; Smith, Eric/C-5443-2012; OI Smith, Eric/0000-0003-3956-1668; Lai, Mei-shu/0000-0001-6130-3468 FU Canadian Institutes for Health Research; Australian Research Council; Department of Health/Higher Education Funding Council; Physicians Services Inc Foundation; Astra Zeneca; Bristol-Myers Squibb; Eisai; Sanofi-aventis; Medicines Company; Zoll LifeCor; Servier; Roche; Glaxo Smith Kline; Pfizer; Bayer; Boehringer Ingelheim; Daiichi-Sankyo; Eli-Lilly; Merck; Novartis; Novo Nordisk; Top Institute Pharma; Dutch Medicines Evaluation Board; Dutch Ministry of Health; Merck-Frost Canada FX Dr Hackam is supported by a Canadian Institutes for Health Research New Investigator Award. Dr Arima is supported by an ARC Future Fellowship from the Australian Research Council. Dr Werring is supported by a Department of Health/Higher Education Funding Council for England Clinical Senior Lecturer Award. The study was funded by a peer-reviewed grant in aid from the Physicians Services Inc Foundation, a nonprofit medical research charity. The funding sources were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.; Dr Bhatt has received research grants from Astra Zeneca, Bristol-Myers Squibb, Eisai, Sanofi-aventis, and The Medicines Company. Dr Psaty serves on a data and safety monitoring board for a clinical trial funded by Zoll LifeCor. Dr Newby reports no direct conflicts of interest with the content of this paper; a full disclosure of her relationships with industry is available at https://www.dcri.org/about-us/conflict-of-interest. Drs Chalmers and MacMahon have received lecture fees and research grants administered through the University of Sydney as a principal investigator of PROGRESS and ADVANCE from Servier. Dr Woodward has received consulting and conference fees from Astra Zeneca, Roche, Glaxo Smith Kline, Pfizer, Sanofi-Aventis, and Servier. Dr Ikeda has received research support from Sanofi-Aventis and Bayer and honoraria from AstraZeneca, GlaxoSmithKline, and Kirin Pharma. Dr Uchiyama has received lecture, consulting, and conference fees and research grants from Boehringer Ingelheim. Dr Danchin has received research grants from Astra-Zeneca, Daiichi-Sankyo, Eli-Lilly, GSK, Merck, Novartis, Pfizer, Sanofi-aventis, Servier, and The Medicines Company. He has also received fees for speaking in industry-sponsored symposia and/or consulting for AstraZeneca, Bristol-Myers Squibb, Boehringer-Ingelheim, GlaxoSmithKline, Lilly, Menarini, MSD-Schering, Novartis, Novo, Pfizer, Sanofi-aventis, Servier, and The Medicines Company. Dr Yamaguchi has served as a consultant for Ohtsuka Pharma and Mitsubishi-Tanabe Pharmaceutical Co and as a Steering Committee member for the J-ASAP and RE-LY trials for Boehringer-Ingelheim. Dr Mamdani has received honoraria for serving on advisory boards for Pfizer, Eli Lilly, Novartis, AstraZeneca, Boehringer-Ingelheim, and GlaxoSmithKline. Dr Verdel is an employee of the Division of Pharmacoepidemiology and Pharmacotherapy at Utrecht University, which has received unrestricted funding for pharmacoepidemiological research from GlaxoSmithKline, Novo Nordisk, the privately and publicly funded Top Institute Pharma (includes cofunding from universities, government, and industry), the Dutch Medicines Evaluation Board, and the Dutch Ministry of Health. Dr Kennedy has received research support and honoraria from Sanofi-aventis and Merck-Frost Canada. The other authors report no conflicts. NR 92 TC 49 Z9 50 U1 0 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD NOV 15 PY 2011 VL 124 IS 20 BP 2233 EP U130 DI 10.1161/CIRCULATIONAHA.111.055269 PG 24 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 848OK UT WOS:000297060700016 PM 22007076 ER PT J AU Sparano, JA Goldstein, LJ Childs, BH Shak, S Brassard, D Badve, S Baehner, FL Bugarini, R Rowley, S Perez, EA Shulman, LN Martino, S Davidson, NE Kenny, PA Sledge, GW Gray, R AF Sparano, Joseph A. Goldstein, Lori J. Childs, Barrett H. Shak, Steven Brassard, Diana Badve, Sunil Baehner, Frederick L. Bugarini, Roberto Rowley, Steve Perez, Edith A. Shulman, Lawrence N. Martino, Silvana Davidson, Nancy E. Kenny, Paraic A. Sledge, George W., Jr. Gray, Robert TI Relationship between Quantitative GRB7 RNA Expression and Recurrence after Adjuvant Anthracycline Chemotherapy in Triple-Negative Breast Cancer SO CLINICAL CANCER RESEARCH LA English DT Article ID POLYMERASE CHAIN-REACTION; BASAL-LIKE SUBTYPE; GENE-EXPRESSION; KINASE INHIBITOR; SOLID TUMORS; IN-VIVO; GROWTH; RECEPTOR; SURVIVAL; PEPTIDE AB Purpose: To conduct an exploratory analysis of the relationship between gene expression and recurrence in patients with operable triple-negative breast cancer (TNBC) treated with adjuvant doxorubicin-containing chemotherapy. Experimental Design: RNA was extracted from archived tumor samples derived from 246 patients with stage I-III TNBC treated with adjuvant doxorubicin-containing chemotherapy, and was analyzed by quantitative reverse transcriptase PCR for a panel of 374 genes. The relationship between gene expression and recurrence was evaluated using weighted Cox proportional hazards model score tests. Results: Growth factor receptor bound protein 7 (GRB7) was the only gene for which higher expression was significantly associated with increased recurrence in TNBC (Korn's adjusted P value = 0.04). In a Cox proportional hazards model adjusted for clinicopathologic features, higher GRB7 expression was associated with an increased recurrence risk (HR = 2.31; P = 0.04 using the median as the split). The 5-year recurrence rates were 10.5% [95% confidence intervals (CI), 7.8-14.1] in the low and 20.4% (95% CI, 16.5-25.0) in the high GRB7 groups. External validation in other datasets indicated that GRB7 expression was not prognostic in two adjuvant trials including variable systemic therapy, but in two other trials showed that high GBR7 expression was associated with resistance to neoadjuvant doxorubicin and taxane therapy. Conclusions: GRB7 was associated with an increased risk of recurrence in TNBC, suggesting that GRB7 or GRB7-dependent pathways may serve as potential biomarkers for therapeutic targets. Therapeutic targeting of one or more factors identified which function as interaction nodes or effectors should also be considered. Clin Cancer Res; 17(22); 7194-203. (C) 2011 AACR. C1 [Sparano, Joseph A.] Albert Einstein Coll Med, Montefiore Med Ctr, Weiler Div, Bronx, NY 10461 USA. [Goldstein, Lori J.; Brassard, Diana] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. [Childs, Barrett H.; Rowley, Steve] Sanofi Aventis, Cambridge, MA USA. [Shak, Steven; Baehner, Frederick L.; Bugarini, Roberto] Genomic Hlth Inc, Redwood City, CA USA. [Badve, Sunil; Sledge, George W., Jr.] Indiana Univ, Simon Canc Ctr, Indianapolis, IN 46204 USA. [Perez, Edith A.] Mayo Clin, Jacksonville, FL 32224 USA. [Shulman, Lawrence N.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Martino, Silvana] Angeles Clin & Res Inst, Santa Monica, CA USA. [Davidson, Nancy E.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. [Gray, Robert] Eastern Cooperat Oncol Grp, Brookline, MA USA. RP Sparano, JA (reprint author), Albert Einstein Coll Med, Montefiore Med Ctr, Weiler Div, 1825 Eastchester Rd, Bronx, NY 10461 USA. EM jsparano@montefiore.org FU Department of Health and Human Services; NIH [CA23318, CA66636, CA21115, CA25224, CA32291, CA32012]; Sanofi-Aventis FX The study was supported, in part, by grants from the Department of Health and Human Services and the NIH (CA23318 to ECOG) statistical center, CA66636 to the ECOG data management center, CA21115 to the ECOG coordinating center, CA25224 to North Central Cancer Treatment Group, CA32291 to Cancer and Leukemia Group B, CA32012 to Southwest Oncology Group), and by a grant from Sanofi-Aventis. NR 45 TC 5 Z9 6 U1 0 U2 5 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD NOV 15 PY 2011 VL 17 IS 22 BP 7194 EP 7203 DI 10.1158/1078-0432.CCR-10-3357 PG 10 WC Oncology SC Oncology GA 849XK UT WOS:000297158500026 PM 21933890 ER PT J AU San Roman, AK Shivdasani, RA AF San Roman, Adrianna K. Shivdasani, Ramesh A. TI Boundaries, junctions and transitions in the gastrointestinal tract SO EXPERIMENTAL CELL RESEARCH LA English DT Review DE Digestive tract development; Gastro-esophageal junction; Gastro-duodenal boundary; Transcriptional regulation of tissue identity; Homeobox genes in gut development ID REGION-SPECIFIC EXPRESSION; EMBRYONAL GUT DEVELOPMENT; MOUSE SMALL-INTESTINE; CDX2 MUTANT MICE; HOX GENES; DIGESTIVE-TRACT; TRANSGENIC MICE; ORGAN FORMATION; HOMEOBOX GENE; STOMACH AB Contiguous regions along the mammalian gastrointestinal tract, from the esophagus to the rectum, serve distinct digestive functions. Some organs, such as the esophagus and glandular stomach or the small bowel and colon, are separated by sharp boundaries. The duodenal, jejunal and ileal segments of the small intestine, by contrast, have imprecise borders. Because human esophageal and gastric cancers frequently arise in a background of tissue metaplasia and some intestinal disorders are confined to discrete regions, it is useful to appreciate the molecular and cellular basis of boundary formation and preservation. Here we review the anatomy and determinants of boundaries and transitions in the alimentary canal with respect to tissue morphology, gene expression, and, especially, transcriptional control of epithelial identity. We discuss the evidence for established and candidate molecular mechanisms of boundary formation, including the solitary and combinatorial actions of tissue-restricted transcription factors. Although the understanding remains sparse, genetic studies in mice do provide insights into dominant mechanisms and point the way for future investigation. (C) 2011 Elsevier Inc. All rights reserved. C1 [San Roman, Adrianna K.; Shivdasani, Ramesh A.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. [San Roman, Adrianna K.] Harvard Univ, Grad Program Biol & Biomed Sci, Cambridge, MA 02138 USA. [Shivdasani, Ramesh A.] Harvard Univ, Sch Med, Boston, MA USA. [Shivdasani, Ramesh A.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. RP Shivdasani, RA (reprint author), Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave, Boston, MA 02215 USA. EM ramesh_shivdasani@dfci.harvard.edu RI San Roman, Adrianna/E-2366-2011 FU NIDDK NIH HHS [R01 DK081113-02, R01 DK081113] NR 51 TC 10 Z9 10 U1 3 U2 12 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4827 J9 EXP CELL RES JI Exp. Cell Res. PD NOV 15 PY 2011 VL 317 IS 19 SI SI BP 2711 EP 2718 DI 10.1016/j.yexcr.2011.07.011 PG 8 WC Oncology; Cell Biology SC Oncology; Cell Biology GA 850JW UT WOS:000297191900003 PM 21802415 ER PT J AU Velho, S Haigis, KM AF Velho, Sergia Haigis, Kevin M. TI Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras SO EXPERIMENTAL CELL RESEARCH LA English DT Review DE Intestinal epithelium; Colorectal cancer; K-Ras ID METASTATIC COLORECTAL-CANCER; GROWTH-FACTOR-BETA; ACTIVATED KI-RAS; COLON-CANCER; N-RAS; 1ST-LINE TREATMENT; ULCERATIVE-COLITIS; TUMOR ANGIOGENESIS; SERRATED POLYPS; MUTATION STATUS AB Much of our current state of knowledge pertaining to the mechanisms controlling intestinal epithelial homeostasis derives from epidemiological, molecular genetic, cell biological, and biochemical studies of signaling pathways that are dysregulated during the process of colorectal tumorigenesis. Activating mutations in members of the RAS oncoprotein family play an important role in the progression of colorectal cancer (CRC) and, by extension, intestinal epithelial homeostasis. Mutations in K-RAS account for 90% of the RAS mutations found in CRC. As such, the study of RAS protein function in the intestinal epithelium is largely encompassed by the study of K-RAS function in CRC. In this review, we summarize the data available from genetically defined in vitro and in vivo models of CRC that aim to characterize the oncogenic properties of mutationally activated K-RAS. These studies paint a complex picture of a multi-functional oncoprotein that engages an array of downstream signaling pathways to influence cellular behaviors that are both pro- and anti-tumorigenic. While the complexity of K-RAS biology has thus far prevented a comprehensive understanding of its oncogenic properties, the work to date lays a foundation for the development of new therapeutic strategies to treat K-RAS mutant CRC. (C) 2011 Elsevier Inc. All rights reserved. C1 [Velho, Sergia; Haigis, Kevin M.] Massachusetts Gen Hosp, Mol Pathol Unit, Ctr Canc Res, Charlestown, MA 02129 USA. [Velho, Sergia; Haigis, Kevin M.] Massachusetts Gen Hosp, Ctr Syst Biol, Charlestown, MA 02129 USA. [Velho, Sergia; Haigis, Kevin M.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA. [Velho, Sergia] Univ Porto, Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal. RP Haigis, KM (reprint author), Massachusetts Gen Hosp, Mol Pathol Unit, Ctr Canc Res, 149 13th St, Charlestown, MA 02129 USA. EM khaigis@partners.org RI Velho, Sergia/B-8501-2013 OI Velho, Sergia/0000-0002-7104-8234 FU NCI NIH HHS [K01 CA118425, K01 CA118425-05]; NIDDK NIH HHS [P30 DK043351] NR 61 TC 7 Z9 7 U1 0 U2 7 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4827 J9 EXP CELL RES JI Exp. Cell Res. PD NOV 15 PY 2011 VL 317 IS 19 SI SI BP 2732 EP 2739 DI 10.1016/j.yexcr.2011.06.002 PG 8 WC Oncology; Cell Biology SC Oncology; Cell Biology GA 850JW UT WOS:000297191900006 PM 21741971 ER PT J AU Del Tredici, K Duda, JE AF Del Tredici, Kelly Duda, John E. TI Peripheral Lewy body pathology in Parkinson's disease and incidental Lewy body disease: Four cases SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article; Proceedings Paper CT 7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinsons Disease and Related Disorders CY DEC 09-12, 2010 CL Barcelona, SPAIN DE Alpha-synuclein; Auerbach plexus; Autonomic nervous system; Axonal; Brainstem; Celiac ganglion; Cognitive dysfunction; Incidental Lewy body disease; Lewy bodies/Lewy neurites; Non-motor symptoms; Parkinson's disease; Submandibular gland; Superior cervical ganglion; Sympathetic trunk; Synucleinopathy; Thyroid gland ID AUTONOMIC NERVOUS-SYSTEM; HUMAN ALPHA-SYNUCLEIN; NONMOTOR SYMPTOMS; MOVEMENT-DISORDERS; AXONAL-TRANSPORT; BRAIN PATHOLOGY; BODIES; PLEXUSES; GANGLIA; DEGENERATION AB The accumulation of Lewy pathology (LP) within autonomic nervous system tissues has received increased attention recently as a possible induction site for Lewy neurodegeneration and a possible source of biopsy material for biomarkers of early Parkinson's disease (PD). Here, we describe LP accumulation within various tissues involving peripheral autonomic nervous system neurons in three PD cases and one case of incidental Lewy body disease. Findings highlight the value of examining pathology within functional neuroanatomical systems and particularly the importance of Lewy neurites (LNs) in the pathophysiology of PD. Published by Elsevier B.V. C1 [Del Tredici, Kelly] Univ Ulm, Dept Neurol, Clin Res Ctr, D-89081 Ulm, Germany. [Duda, John E.] Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USA. [Duda, John E.] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA. RP Del Tredici, K (reprint author), Univ Ulm, Dept Neurol, Clin Res Ctr, Helmholtzstr 8-1, D-89081 Ulm, Germany. EM kelly.del-tredici@uni-ulm.de NR 48 TC 10 Z9 10 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD NOV 15 PY 2011 VL 310 IS 1-2 SI SI BP 100 EP 106 DI 10.1016/j.jns.2011.06.003 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 846UA UT WOS:000296927500025 PM 21689832 ER PT J AU Morley, JF Duda, JE AF Morley, James F. Duda, John E. TI Neuropsychological correlates of olfactory dysfunction in Parkinson's disease SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article; Proceedings Paper CT 7th International Congress on Mental Dysfunction and Other Non-Motor Features in Parkinson's Disease and Related Disorders CY DEC 09-12, 2010 CL Barcelona, SPAIN DE Parkinson's disease; Olfaction; Non-motor symptoms; Psychiatric symptoms; Cognitive symptoms ID ODOR IDENTIFICATION; COGNITIVE IMPAIRMENT; BODY PATHOLOGY; DEFICITS; RISK; DISCRIMINATION; SYMPTOMS; SIGN AB Olfactory impairment is a common early non-motor manifestation in Parkinson's disease that has garnered interest as a clinical biomarker for early "pre-motor" diagnosis and prediction of associated clinical phenotypes. Whether olfactory impairment correlates well with motor symptoms is not yet clear, and recent interest has focused on the relationship between hyposmia and other non-motor symptoms. In this paper, we will review emerging evidence for a relationship between hyposmia and neuropsychiatric manifestations, discussing the potential pathophysiology together with challenges and opportunities for future research. Published by Elsevier B.V. C1 [Duda, John E.] Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USA. Univ Penn, Dept Neurol, Sch Med, Philadelphia, PA 19104 USA. RP Duda, JE (reprint author), Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, 3900 Woodland Ave, Philadelphia, PA 19104 USA. EM John.Duda@va.gov NR 31 TC 7 Z9 7 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD NOV 15 PY 2011 VL 310 IS 1-2 SI SI BP 228 EP 230 DI 10.1016/j.jns.2011.05.030 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 846UA UT WOS:000296927500050 PM 21658728 ER PT J AU Sharp, JA Plant, JJ Ohsumi, TK Borowsky, M Blower, MD AF Sharp, Judith A. Plant, Joshua J. Ohsumi, Toshiro K. Borowsky, Mark Blower, Michael D. TI Functional analysis of the microtubule-interacting transcriptome SO MOLECULAR BIOLOGY OF THE CELL LA English DT Article ID MESSENGER-RNA LOCALIZATION; RIBOSOME ENTRY SITE; CELL-CYCLE; PROTEIN-SYNTHESIS; MITOTIC SPINDLE; XENOPUS-LAEVIS; IN-VITRO; TRANSLATIONAL CONTROL; INNER CENTROMERE; GAMMA-TUBULIN AB RNA localization is an important mechanism for achieving precise control of post-transcriptional gene expression. Previously, we demonstrated that a subset of cellular mRNAs copurify with mitotic microtubules in egg extracts of Xenopus laevis. Due to limited genomic sequence information available for X. laevis, we used RNA-seq to comprehensively identify the microtubule-interacting transcriptome of the related frog Xenopus tropicalis. We identified similar to 450 mRNAs that showed significant enrichment on microtubules (MT-RNAs). In addition, we demonstrated that the MT-RNAs incenp, xrhamm, and tpx2 associate with spindle microtubules in vivo. MT-RNAs are enriched with transcripts associated with cell division, spindle formation, and chromosome function, demonstrating an overrepresentation of genes involved in mitotic regulation. To test whether uncharacterized MT-RNAs have a functional role in mitosis, we performed RNA interference and discovered that several MT-RNAs are required for normal spindle pole organization and.-tubulin distribution. Together, these data demonstrate that microtubule association is one mechanism for compartmentalizing functionally related mRNAs within the nucleocytoplasmic space of mitotic cells and suggest that MT-RNAs are likely to contribute to spindle-localized mitotic translation. C1 [Blower, Michael D.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. RP Blower, MD (reprint author), Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. EM blower@molbio.mgh.harvard.edu FU Pfizer; Life Science Research Foundation; Massachusetts Biomedical Research Corporation; Burroughs Wellcome Fund FX We thank members of the Blower laboratory, Tom Fazzio, and Paul Kaufman for helpful discussions and Marvin Fritzler for the GW182 antibodies. J.A.S. was supported by a Pfizer Fellowship from the Life Science Research Foundation and a Tosteson Award from the Massachusetts Biomedical Research Corporation. M. D. B. was supported by a Burroughs Wellcome Fund Career Award. NR 68 TC 26 Z9 27 U1 0 U2 3 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV 15 PY 2011 VL 22 IS 22 BP 4312 EP 4323 DI 10.1091/mbc.E11-07-0629 PG 12 WC Cell Biology SC Cell Biology GA 849ZM UT WOS:000297164200011 PM 21937723 ER PT J AU Devarakonda, S Gupta, K Chalmers, MJ Hunt, JF Griffin, PR Van Duyne, GD Spiegelman, BM AF Devarakonda, Srikripa Gupta, Kushol Chalmers, Michael J. Hunt, John F. Griffin, Patrick R. Van Duyne, Gregory D. Spiegelman, Bruce M. TI Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1 alpha/ERR gamma complex SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID X-RAY-SCATTERING; LIGAND-BINDING DOMAIN; RECEPTOR-ALPHA; ERR-ALPHA; BIOLOGICAL MACROMOLECULES; MITOCHONDRIAL BIOGENESIS; PROTEIN; GAMMA; COACTIVATOR; ACTIVATION AB Peroxisome proliferator activated receptor (PPAR) gamma coactivator-1 alpha (PGC-1 alpha) is a potent transcriptional coactivator of oxidative metabolism and is induced in response to a variety of environmental cues. It regulates a broad array of target genes by coactivating a whole host of transcription factors. The estrogen-related receptor (ERR) family of nuclear receptors are key PGC-1 alpha partners in the regulation of mitochondrial and tissue-specific oxidative metabolic pathways; these receptors also demonstrate strong physical and functional interactions with this coactivator. Here we perform comprehensive biochemical, biophysical, and structural analyses of the complex formed between PGC-1 alpha and ERR gamma. PGC-1 alpha activation domain (PGC-1 alpha(2-220)) is intrinsically disordered with limited secondary and no defined tertiary structure. Complex formation with ERR. induces significant changes in the conformational mobility of both partners, highlighted by significant stabilization of the ligand binding domain (ERR gamma LBD) as determined by HDX (hydrogen/deuterium exchange) and an observed disorder-to-order transition in PGC-1 alpha(2-220). Small-angle X-ray scattering studies allow for modeling of the solution structure of the activation domain in the absence and presence of ERR gamma LBD, revealing a stable and compact binary complex. These data show that PGC-1 alpha(2-220) undergoes a large-scale conformational change when binding to the ERR gamma LBD, LBD, leading to substantial compaction of the activation domain. This change results in stable positioning of the N-terminal part of the activation domain of PGC-1 alpha, favorable for assembly of an active transcriptional complex. These data also provide structural insight into the versatile coactivation profile of PGC-1 alpha and can readily be extended to understand other transcriptional coregulators. C1 [Devarakonda, Srikripa; Spiegelman, Bruce M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Devarakonda, Srikripa; Spiegelman, Bruce M.] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA. [Gupta, Kushol; Van Duyne, Gregory D.] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA. [Gupta, Kushol; Van Duyne, Gregory D.] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA. [Chalmers, Michael J.; Griffin, Patrick R.] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USA. [Hunt, John F.] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA. [Hunt, John F.] Columbia Univ, NE Struct Genom Consortium, New York, NY 10027 USA. RP Spiegelman, BM (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, 44 Binney St, Boston, MA 02115 USA. EM bruce_spiegelman@dfci.havard.edu RI ROBINE, Ophelie/A-1641-2012 FU National Science Foundation (NSF); National Institutes of Health (NIH)/National Institute of General Medical Sciences via NSF [DMR-0936384]; NIH/National Center for Research Resources [RR-01646]; Department of Energy (DOE) [DE-AC02-05CH11231]; US Department of Energy [DE-AC02-05CH11231]; NIH [R01 DK54477, R01 DK061562, R01 GM084041, U54GM074958, U54GM094597]; Susan Komen Breast Cancer Foundation; Naomi Berrie Fellowship for Diabetes Research FX We thank Drs. Jorge L. Ruas, Sandra Kleiner, and Chi Wang for helpful discussions, Prof. Scott Banta (Columbia University) for use of laboratory equipment, Bruce Pascal and Scott Novick for help with hydrogen/deuterium exchange data acquisition and tools for data analysis and Gregory Hura, Jane Tanamachi, Kevin Dyer, and Michael Hammel [Advanced Light Source (ALS)], and Richard Gillilan [Cornell High Energy Synchrotron Source (CHESS)] for assistance with data collection. CHESS is supported by the National Science Foundation (NSF) and National Institutes of Health (NIH)/National Institute of General Medical Sciences via NSF award DMR-0936384, and the MacCHESS resource is supported by NIH/National Center for Research Resources award RR-01646. X-ray scattering and diffraction technologies and their applications to the determination of macromolecular shapes and conformations at the SIBYLS beamline at the ALS, Lawrence Berkeley National Laboratory, are supported in part by the Department of Energy (DOE) program Integrated Diffraction Analysis Technologies and the DOE program Molecular Assemblies Genes and Genomics Integrated Efficiently under contract DE-AC02-05CH11231 with the US Department of Energy. This work was supported by NIH Grants R01 DK54477 and R01 DK061562 (to B.M.S), R01 GM084041 (to P.R.G), U54GM074958 and U54GM094597 (to Northeast Structural Genomics Consortium), and Susan Komen Breast Cancer Foundation Postdoctoral Fellowship and the Naomi Berrie Fellowship for Diabetes Research (S.D.). NR 40 TC 24 Z9 25 U1 0 U2 8 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 15 PY 2011 VL 108 IS 46 BP 18678 EP 18683 DI 10.1073/pnas.1113813108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 847XQ UT WOS:000297008900032 PM 22049338 ER PT J AU Gillet, JP Calcagno, AM Varma, S Marino, M Green, LJ Vora, MI Patel, C Orina, JN Eliseeva, TA Singal, V Padmanabhan, R Davidson, B Ganapathi, R Sood, AK Rueda, BR Ambudkar, SV Gottesman, MM AF Gillet, Jean-Pierre Calcagno, Anna Maria Varma, Sudhir Marino, Miguel Green, Lisa J. Vora, Meena I. Patel, Chirayu Orina, Josiah N. Eliseeva, Tatiana A. Singal, Vineet Padmanabhan, Raji Davidson, Ben Ganapathi, Ram Sood, Anil K. Rueda, Bo R. Ambudkar, Suresh V. Gottesman, Michael M. TI Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE gene signature; NCI-60 panel; translational medicine; gene expression profiling assay; cell culture model ID BINDING CASSETTE TRANSPORTERS; OVARIAN-CANCER; MULTIDRUG-RESISTANCE; GENE-EXPRESSION; CROSS-RESISTANCE; MYELOID-LEUKEMIA; CHEMOTHERAPY; MICROARRAY; AGENTS; P53 AB Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has been uncertain. Using a state-of-the-art Taqman-based quantitative RT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types, in established cancer cell lines (grown in monolayer, 3D scaffold, or in xenograft) and clinical samples, either containing >75% tumor cells or micro-dissected. The MDR transcriptome was determined a priori based on an extensive curation of the literature published during the last three decades, which led to the enumeration of 380 genes. No correlation was found between clinical samples and established cancer cell lines. As expected, we found up-regulation of genes that would facilitate survival across all cultured cancer cell lines evaluated. More troubling, however, were data showing that all of the cell lines, grown either in vitro or in vivo, bear more resemblance to each other, regardless of the tissue of origin, than to the clinical samples they are supposed to model. Although cultured cells can be used to study many aspects of cancer biology and response of cells to drugs, this study emphasizes the necessity for new in vitro cancer models and the use of primary tumor models in which gene expression can be manipulated and small molecules tested in a setting that more closely mimics the in vivo cancer microenvironment so as to avoid radical changes in gene expression profiles brought on by extended periods of cell culture. C1 [Gillet, Jean-Pierre; Calcagno, Anna Maria; Marino, Miguel; Green, Lisa J.; Patel, Chirayu; Orina, Josiah N.; Eliseeva, Tatiana A.; Singal, Vineet; Padmanabhan, Raji; Ambudkar, Suresh V.; Gottesman, Michael M.] NCI, Cell Biol Lab, Ctr Canc Res, Bethesda, MD 20892 USA. [Varma, Sudhir] NIAID, Bioinformat & Computat Biosci Branch, Off Cyber Infrastruct & Computat Biol, Off Sci Management & Operat,NIH, Bethesda, MD 20892 USA. [Vora, Meena I.] Biophase Syst, Fremont, CA 94539 USA. [Davidson, Ben] Oslo Univ Hosp, Div Pathol, Norwegian Radium Hosp, N-0310 Oslo, Norway. [Davidson, Ben] Univ Oslo, Fac Med, N-0310 Oslo, Norway. [Ganapathi, Ram] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44195 USA. [Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA. [Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA. [Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA. [Rueda, Bo R.] Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Vincent Dept Obstet & Gynecol, Boston, MA 02114 USA. RP Gottesman, MM (reprint author), NCI, Cell Biol Lab, Ctr Canc Res, Bethesda, MD 20892 USA. EM mgottesman@nih.gov RI gillet, jean-pierre/A-3714-2012; Calcagno, Anna Maria/A-5617-2012; Varma, Sudhir/N-8763-2014; 木子, 瑞/N-8882-2015; OI Varma, Sudhir/0000-0002-4096-4782; Calcagno, Anna Maria/0000-0002-0804-2753 FU NIH, Center for Cancer Research, NCI FX We thank the Developmental Therapeutics Program for the total RNA from the NCI-60 cell panel; George Leiman for editorial assistance; and L. Stenke, M. Lindberg, M. Bjorkholm, J. Sjoberg, K. Viktorsson, R. Lewensohn (Karolinska Institutet), S. A. Rosenberg [Tumor Immunology Section Branch, National Cancer Institute (NCI), National Institutes of Health (NIH)], T. Waldman (Lombardi Comprehensive Cancer Center, Georgetown University), C. Harris, A. Schetter (Laboratory of Human Carcinogenesis, NCI, NIH), J. Keller (Laboratory of Cancer Prevention, NCI, NIH), P. Liu (Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH), L. Wolff (Laboratory of Cellular Oncology, NCI, NIH), T. Fojo, and L. Mickley Huff (Medical Oncology Branch, NCI, NIH) for generously providing clinical cancer samples. The BRB-ArrayTools were developed by Richard Simon and colleagues (Biometric Research Branch, National Cancer Institute). This research was supported by the Intramural Research Program of the NIH, Center for Cancer Research, NCI. NR 45 TC 112 Z9 115 U1 3 U2 24 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 15 PY 2011 VL 108 IS 46 BP 18708 EP 18713 DI 10.1073/pnas.1111840108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 847XQ UT WOS:000297008900037 PM 22068913 ER PT J AU Liao, S Cheng, G Conner, DA Huang, YH Kucherlapati, RS Munn, LL Ruddle, NH Jain, RK Fukumura, D Padera, TP AF Liao, Shan Cheng, Gang Conner, David A. Huang, Yuhui Kucherlapati, Raju S. Munn, Lance L. Ruddle, Nancy H. Jain, Rakesh K. Fukumura, Dai Padera, Timothy P. TI Impaired lymphatic contraction associated with immunosuppression SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID NITRIC-OXIDE SYNTHASE; GUINEA-PIG MESENTERY; PUMP ACTIVITY; DENDRITIC CELLS; IN-VIVO; VESSELS; MECHANISM; METASTASIS; SYSTEM; NODES AB To trigger an effective immune response, antigen and antigen-presenting cells travel to the lymph nodes via collecting lymphatic vessels. However, our understanding of the regulation of collecting lymphatic vessel function and lymph transport is limited. To dissect the molecular control of lymphatic function, we developed a unique mouse model that allows intravital imaging of autonomous lymphatic vessel contraction. Using this method, we demonstrated that endothelial nitric oxide synthase ( eNOS) in lymphatic endothelial cells is required for robust lymphatic contractions under physiological conditions. By contrast, under inflammatory conditions, inducible NOS (iNOS)-expressing CD11b(+)Gr-1(+) cells attenuate lymphatic contraction. This inhibition of lymphatic contraction was associated with a reduction in the response to antigen in a model of immune-induced multiple sclerosis. These results suggest the suppression of lymphatic function by the CD11b(+)Gr-1(+) cells as a potential mechanism of self-protection from autoreactive responses during on-going inflammation. The central role for nitric oxide also suggests that other diseases such as cancer and infection may also mediate lymphatic contraction and thus immune response. Our unique method allows the study of lymphatic function and its molecular regulation during inflammation, lymphedema, and lymphatic metastasis. C1 [Liao, Shan; Cheng, Gang; Huang, Yuhui; Munn, Lance L.; Jain, Rakesh K.; Fukumura, Dai; Padera, Timothy P.] Harvard Univ, Sch Med, EL Steele Lab, Dept Radiat Oncol, Boston, MA 02114 USA. [Liao, Shan; Cheng, Gang; Huang, Yuhui; Munn, Lance L.; Jain, Rakesh K.; Fukumura, Dai; Padera, Timothy P.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Conner, David A.; Kucherlapati, Raju S.] Brigham & Womens Hosp, Dept Genet, Boston, MA 02115 USA. [Ruddle, Nancy H.] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06511 USA. [Ruddle, Nancy H.] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06511 USA. RP Jain, RK (reprint author), Harvard Univ, Sch Med, EL Steele Lab, Dept Radiat Oncol, Boston, MA 02114 USA. EM jain@steele.mgh.harvard.edu; dai@steele.mgh.harvard.edu; tpadera@steele.mgh.harvard.edu RI Munn, Lance/L-3950-2016; OI Munn, Lance/0000-0003-0698-7232; Huang, Yuhui/0000-0003-1985-3575; Padera, Timothy/0000-0002-3453-9384 FU Massachusetts Biomedical Research Corporation; Charles A. King Trust; National Institutes of Health [R01 DK57731]; Multiple Sclerosis Society [RG 4126-A-7, U01-CA084301]; National Cancer Institute [R01-CA96915, R01-CA85140, R01-CA115767, R01-CA126642, P01-CA80124, K99-CA137167]; Dyax; MedImmune; Roche; SynDevRx; Xtuit; Noxxon Pharma FX We thank Qingcong Lin, Paul L. Huang, Peigen Huang, and Ravi Mylvaganam as well as the Massachusetts General Hospital Flow Cytometry Core for reagents and expertise. This study was supported in part by a Tosteson Postdoctoral Fellowship from the Massachusetts Biomedical Research Corporation (to S.L.); a Charles A. King Trust Fellowship Award (to S.L.); National Institutes of Health Grant R01 DK57731 and Multiple Sclerosis Society Grants RG 4126-A-7 (to N.H.R.) and U01-CA084301 (to R. S. K.); and National Cancer Institute Grants R01-CA96915 (to D.F.), R01-CA85140, R01-CA115767, R01-CA126642 (to R.K.J.), P01-CA80124 (to R.K.J., D.F., and L.L.M.), and K99-CA137167 (to T.P.P.).; R.K.J. received commercial research grants from Dyax, MedImmune, and Roche; consultant fees from Dyax, SynDevRx, Xtuit, and Noxxon Pharma; and a speaker honorarium from MPM Capital. R.K.J. owns stock in SynDevRx. No reagents or funding from these companies were used in these studies. NR 42 TC 79 Z9 79 U1 0 U2 4 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 15 PY 2011 VL 108 IS 46 BP 18784 EP 18789 DI 10.1073/pnas.1116152108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 847XQ UT WOS:000297008900050 PM 22065738 ER PT J AU Koffie, RM Farrar, CT Saidi, LJ William, CM Hyman, BT Spires-Jones, TL AF Koffie, Robert M. Farrar, Christian T. Saidi, Laiq-Jan William, Christopher M. Hyman, Bradley T. Spires-Jones, Tara L. TI Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE in vivo multiphoton imaging; transgenic mice ID 80-COATED POLYBUTYLCYANOACRYLATE NANOPARTICLES; ALZHEIMERS-DISEASE; MULTIPHOTON MICROSCOPY; COGNITIVE FUNCTION; TRANSGENIC MICE; DRUG-DELIVERY; CONGO RED; INCREASE; PLAQUES; PERMEABILITY AB Several imaging modalities are suitable for in vivo molecular neuroimaging, but the blood-brain barrier (BBB) limits their utility by preventing brain delivery of most targeted molecular probes. We prepared biodegradable nanocarrier systems made up of poly(n-butyl cyanoacrylate) dextran polymers coated with polysorbate 80 (PBCA nanoparticles) to deliver BBB-impermeable molecular imaging probes into the brain for targeted molecular neuroimaging. We demonstrate that PBCA nanoparticles allow in vivo targeting of BBB-impermeable contrast agents and staining reagents for electron microscopy, optical imaging (multiphoton), and whole brain magnetic resonance imaging (MRI), facilitating molecular studies ranging from individual synapses to the entire brain. PBCA nanoparticles can deliver BBB-impermeable targeted fluorophores of a wide range of sizes: from 500-Da targeted polar molecules to 150,000-Da tagged immunoglobulins into the brain of living mice. The utility of this approach is demonstrated by (i) development of a "Nissl stain" contrast agent for cellular imaging, (ii) visualization of amyloid plaques in vivo in a mouse model of Alzheimer's disease using (traditionally) non-BBB-permeable reagents that detect plaques, and (iii) delivery of gadolinium-based contrast agents into the brain of mice for in vivo whole brain MRI. Four-dimensional real-time two-photon and MR imaging reveal that brain penetration of PBCA nanoparticles occurs rapidly with a time constant of similar to 18 min. PBCA nanoparticles do not induce nonspecific BBB disruption, but collaborate with plasma apolipoprotein E to facilitate BBB crossing. Collectively, these findings highlight the potential of using biodegradable nanocarrier systems to deliver BBB-impermeable targeted molecular probes into the brain for diagnostic neuroimaging. C1 [Koffie, Robert M.; Saidi, Laiq-Jan; William, Christopher M.; Hyman, Bradley T.; Spires-Jones, Tara L.] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA. [Koffie, Robert M.; Farrar, Christian T.; Saidi, Laiq-Jan; William, Christopher M.; Hyman, Bradley T.; Spires-Jones, Tara L.] Harvard Univ, Sch Med, Charlestown, MA 02129 USA. [Koffie, Robert M.] Harvard Univ, Harvard Biophys Program, Boston, MA 02115 USA. [Farrar, Christian T.] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA. RP Spires-Jones, TL (reprint author), Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA. EM tspires@partners.org OI William, Christopher/0000-0001-8933-1639; Spires-Jones, Tara/0000-0003-2530-0598 FU National Institutes of Health (NIH) [K99 AG033670, K25 AG029415, K08 NS069811, P50 AG005134, AG12406, AG08487]; Alzheimer's Research Trust; Harvard Biophysics and Medical Scientist Training Programs [NIH T32 GM07753]; Paul and Daisy Soros Foundation; Foundation Family FX We thank Dr. Marian DiFiglia for use of the transmission electron microscope and Dr. Peter Caravan for the use of the ICP-MS. This work was supported by National Institutes of Health (NIH) Grants K99 AG033670, K25 AG029415, K08 NS069811, P50 AG005134, AG12406, and AG08487, and a Coins for Alzheimer's Research Trust award. R.M.K. is supported by the Harvard Biophysics and Medical Scientist Training Programs (NIH T32 GM07753) and the Paul and Daisy Soros Foundation. L.-J.S. is supported by the Foundation Family Klee Young Scientist Award. NR 36 TC 93 Z9 94 U1 2 U2 59 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 15 PY 2011 VL 108 IS 46 BP 18837 EP 18842 DI 10.1073/pnas.1111405108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 847XQ UT WOS:000297008900059 PM 22065785 ER PT J AU MacLauchlan, S Yu, J Parrish, M Asoulin, TA Schleicher, M Krady, MM Zeng, JM Huang, PL Sessa, WC Kyriakides, TR AF MacLauchlan, Susan Yu, Jun Parrish, Marcus Asoulin, Tara A. Schleicher, Michael Krady, Marie M. Zeng, Jianmin Huang, Paul L. Sessa, William C. Kyriakides, Themis R. TI Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2 SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE wound healing; extracellular matrix; Akt; matrix metalloproteinases ID COLLAGEN-SYNTHESIS; VASCULAR MATURATION; MESANGIAL CELLS; IN-VIVO; MICE; ACTIVATION; PROTEIN; ANGIOSTATIN; FIBROBLASTS; DENSITY AB Injury- and ischemia-induced angiogenesis is critical for tissue repair and requires nitric oxide (NO) derived from endothelial nitric oxide synthase (eNOS). We present evidence that NO induces angiogenesis by modulating the level of the angiogenesis inhibitor thrombospondin 2 (TSP2). TSP2 levels were higher than WT in eNOS KO tissues in hind-limb ischemia and cutaneous wounds. In vitro studies confirmed that NO represses TSP2 promoter activity. Moreover, double-eNOS/TSP2 KO mice were generated and found to rescue the phenotype of eNOS KO mice. Studies in mice with knock-in constitutively active or inactive eNOS on the Akt-1 KO background showed that eNOS activity correlates with TSP2 levels. Our observations of NO-mediated regulation of angiogenesis via the suppression of TSP2 expression provide a description of improved eNOS KO phenotype by means other than restoring NO signaling. C1 [MacLauchlan, Susan; Yu, Jun; Parrish, Marcus; Asoulin, Tara A.; Schleicher, Michael; Krady, Marie M.; Zeng, Jianmin; Sessa, William C.; Kyriakides, Themis R.] Yale Univ, Sch Med, Interdept Program Vasc Biol & Therapeut, New Haven, CT 06520 USA. [MacLauchlan, Susan; Asoulin, Tara A.; Krady, Marie M.; Zeng, Jianmin; Kyriakides, Themis R.] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA. [Yu, Jun; Schleicher, Michael; Sessa, William C.] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA. [Huang, Paul L.] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02129 USA. [Huang, Paul L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02129 USA. RP Kyriakides, TR (reprint author), Yale Univ, Sch Med, Interdept Program Vasc Biol & Therapeut, 333 Cedar St, New Haven, CT 06520 USA. EM themis.kyriakides@yale.edu OI Maclauchlan, Susan/0000-0001-9689-0826 FU National Institutes of Health [GM-072194-01]; American Heart Association [09PRE2080166] FX We thank Dr. Kurt Hankenson (University of Pennsylvania) for the 2-kb TSP2 promoter construct. This work was funded by National Institutes of Health Grant GM-072194-01 (to T.R.K). S.M. is funded by American Heart Association Predoctoral Grant 09PRE2080166. NR 53 TC 15 Z9 16 U1 0 U2 5 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 15 PY 2011 VL 108 IS 46 BP E1137 EP E1145 DI 10.1073/pnas.1104357108 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 847XQ UT WOS:000297008900007 PM 21949402 ER PT J AU Xi, RB Hadjipanayis, AG Luquette, LJ Kim, TM Lee, E Zhang, JH Johnson, MD Muzny, DM Wheeler, DA Gibbs, RA Kucherlapati, R Park, PJ AF Xi, Ruibin Hadjipanayis, Angela G. Luquette, Lovelace J. Kim, Tae-Min Lee, Eunjung Zhang, Jianhua Johnson, Mark D. Muzny, Donna M. Wheeler, David A. Gibbs, Richard A. Kucherlapati, Raju Park, Peter J. TI Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE structural variation; genomic alterations; model selection; semiparametric model ID RARE CHROMOSOMAL DELETIONS; MYELOID-LEUKEMIA GENOME; TUMOR-SUPPRESSOR GENE; STRUCTURAL VARIATION; POPULATION-SCALE; CANCER; GLIOBLASTOMA; ARRAY; SCHIZOPHRENIA; ALGORITHMS AB DNA copy number variations (CNVs) play an important role in the pathogenesis and progression of cancer and confer susceptibility to a variety of human disorders. Array comparative genomic hybridization has been used widely to identify CNVs genome wide, but the next-generation sequencing technology provides an opportunity to characterize CNVs genome wide with unprecedented resolution. In this study, we developed an algorithm to detect CNVs from whole-genome sequencing data and applied it to a newly sequenced glioblastoma genome with a matched control. This read-depth algorithm, called BIC-seq, can accurately and efficiently identify CNVs via minimizing the Bayesian information criterion. Using BIC-seq, we identified hundreds of CNVs as small as 40 bp in the cancer genome sequenced at 10x coverage, whereas we could only detect large CNVs (>15 kb) in the array comparative genomic hybridization profiles for the same genome. Eighty percent (14/16) of the small variants tested (110 bp to 14 kb) were experimentally validated by quantitative PCR, demonstrating high sensitivity and true positive rate of the algorithm. We also extended the algorithm to detect recurrent CNVs in multiple samples as well as deriving error bars for breakpoints using a Gibbs sampling approach. We propose this statistical approach as a principled yet practical and efficient method to estimate CNVs in whole-genome sequencing data. C1 [Xi, Ruibin; Luquette, Lovelace J.; Kim, Tae-Min; Lee, Eunjung; Park, Peter J.] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA. [Hadjipanayis, Angela G.; Lee, Eunjung; Kucherlapati, Raju; Park, Peter J.] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA. [Zhang, Jianhua] Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA 02115 USA. [Johnson, Mark D.] Brigham & Womens Hosp, Dept Neurol Surg, Boston, MA 02115 USA. [Muzny, Donna M.; Wheeler, David A.; Gibbs, Richard A.] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA. [Kucherlapati, Raju] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [Park, Peter J.] Childrens Hosp, Informat Program, Boston, MA 02115 USA. RP Park, PJ (reprint author), Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA. EM peter_park@harvard.edu FU US National Institutes of Health [RC1 HG005482, R01 GM082798, U24 CA144025] FX This work was supported by the US National Institutes of Health Grants RC1 HG005482 and R01 GM082798 (to P.J.P.) and U24 CA144025 (to R.K.). NR 53 TC 76 Z9 79 U1 1 U2 10 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 15 PY 2011 VL 108 IS 46 BP E1128 EP E1136 DI 10.1073/pnas.1110574108 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 847XQ UT WOS:000297008900006 PM 22065754 ER PT J AU Eberlin, LS Liu, XH Ferreira, CR Santagata, S Agar, NYR Cooks, RG AF Eberlin, Livia S. Liu, Xiaohui Ferreira, Christina R. Santagata, Sandro Agar, Nathalie Y. R. Cooks, R. Graham TI Desorption Electrospray Ionization then MALDI Mass Spectrometry Imaging of Lipid and Protein Distributions in Single Tissue Sections SO ANALYTICAL CHEMISTRY LA English DT Article ID MOUSE-BRAIN AB Imaging mass spectrometry (MS) is a powerful technique for mapping the spatial distributions of a wide range of chemical compounds simultaneously from a tissue section. Co-localization of the distribution of individual molecular species, including particular lipids and proteins, and correlation with the morphological features of a single tissue section are highly desirable for comprehensive tissue analysis and disease diagnosis. We now report on the use, in turn, of desorption electrospray ionization (DESI), matrix assisted laser desorption ionization (MALDI), and then optical microscopy to image lipid and protein distributions in a single tissue section. This is possible through the use of histologically compatible DESI solvent systems, which allow for sequential analyses of the same section by DESI then MALDI. Hematoxylin and eosin (H&E) staining was performed on the same section after removal of the MALDI matrix. This workflow allowed chemical information to be unambiguously matched to histological features in mouse brain tissue sections. The lipid sulfatide (24:1), detected at m/z 888.8 by DESI imaging, was colocalized with the protein MBP isoform 8, detected at m/z 14117 by MALDI imaging, in regions corresponding to the corpus callosum substructure of the mouse brain, as confirmed in the H&E images. Correlation of lipid and protein distributions with histopathological features was also achieved for human brain cancer samples. Higher tumor cell density was observed in regions demonstrating higher relative abundances of oleic acid, detected by DESI imaging at m/z 281.4, and the protein calcyclin, detected by MALDI at m/z 10085, for a human glioma sample. Since correlation between molecular signatures and disease state can be achieved, we expect that this methodology will significantly enhance the value of MS imaging in molecular pathology for diagnosis. C1 [Liu, Xiaohui; Agar, Nathalie Y. R.] Harvard Univ, Sch Med, Dept Neurosurg, Dept Radiol, Boston, MA 02115 USA. [Liu, Xiaohui; Agar, Nathalie Y. R.] Harvard Univ, Sch Med, Dept Med Oncol, Brigham & Womens Hosp, Boston, MA 02115 USA. [Liu, Xiaohui; Agar, Nathalie Y. R.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Eberlin, Livia S.; Ferreira, Christina R.; Cooks, R. Graham] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA. [Eberlin, Livia S.; Ferreira, Christina R.; Cooks, R. Graham] Purdue Univ, Ctr Analyt Instrumentat Dev, W Lafayette, IN 47907 USA. [Santagata, Sandro] Harvard Univ, Brigham & Womens Hosp, Dept Pathol, Sch Med, Boston, MA 02115 USA. RP Agar, NYR (reprint author), Harvard Univ, Brigham & Womens Hosp, Dept Neurosurg, Sch Med, Boston, MA 02115 USA. EM nagar@bwh.harvard.edu; cooks@purdue.edu RI Ferreira, Christina/F-4744-2012; Cooks, R/G-1051-2015 OI Cooks, R/0000-0002-9581-9603 FU ACS Division of Analytical Chemistry and Agilent Technologies; U.S. National Institute of Health [1R21EB009459-01]; Purdue University Center for Cancer Research; NIH [1DP2OD007383-01, K08NS064168]; V Foundation for Cancer Research FX L.S.E. thanks the ACS Division of Analytical Chemistry and Agilent Technologies for research summer fellowship. L.S.E., C.R.F., and RG.C. thank the U.S. National Institute of Health (Grant 1R21EB009459-01) and the Purdue University Center for Cancer Research and its director Dr. Timothy Ratliff for assistance and support. N.Y.R.A. thanks the DFCI Low-Grade Astrocytoma (PLGA) Program, the BWH Institute for the Neurosciences, and the NIH Director's New Innovator Award (Grant 1DP2OD007383-01). S.S. acknowledges the support of the National Institutes of Health (K08NS064168) and the V Foundation for Cancer Research. L.S.E. gratefully acknowledges Prof. Demian R. Ifa of York University for valuable discussions. NR 33 TC 55 Z9 55 U1 8 U2 113 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD NOV 15 PY 2011 VL 83 IS 22 BP 8366 EP 8371 DI 10.1021/ac202016x PG 6 WC Chemistry, Analytical SC Chemistry GA 845NQ UT WOS:000296830200002 PM 21975048 ER PT J AU Beyth, RJ Landefeld, CS AF Beyth, Rebecca J. Landefeld, C. Seth TI Learning the Respective Roles of Warfarin and Dabigatran to Prevent Stroke in Patients With Nonvalvular Atrial Fibrillation SO ANNALS OF INTERNAL MEDICINE LA English DT Editorial Material ID THERAPY; ANTICOAGULATION C1 [Landefeld, C. Seth] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94118 USA. [Landefeld, C. Seth] San Francisco VA Med Ctr, San Francisco, CA 94118 USA. [Beyth, Rebecca J.] Univ Florida, Gainesville, FL 32608 USA. [Beyth, Rebecca J.] N Florida S Georgia Vet Hlth Syst, Gainesville, FL 32608 USA. RP Landefeld, CS (reprint author), Univ Calif San Francisco, Div Geriatr, Suite 380,3333 Calif St, San Francisco, CA 94118 USA. NR 12 TC 2 Z9 2 U1 0 U2 2 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 15 PY 2011 VL 155 IS 10 BP 714 EP + DI 10.7326/0003-4819-155-10-201111150-00012 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 849EI UT WOS:000297108000008 PM 22084336 ER PT J AU Zeidan, MA Igoe, SA Linnman, C Vitalo, A Levine, JB Klibanski, A Goldstein, JM Milad, MR AF Zeidan, Mohamed A. Igoe, Sarah A. Linnman, Clas Vitalo, Antonia Levine, John B. Klibanski, Anne Goldstein, Jill M. Milad, Mohammed R. TI Estradiol Modulates Medial Prefrontal Cortex and Amygdala Activity During Fear Extinction in Women and Female Rats SO BIOLOGICAL PSYCHIATRY LA English DT Article DE Classical conditioning; estrogen; fear inhibition; fMRI; menstrual cycle; progesterone ID ESTROGEN-RECEPTOR BETA; ANXIETY DISORDERS; CONDITIONED FEAR; SEX-DIFFERENCES; NEURONAL CIRCUITS; GENE-EXPRESSION; ANTI-ANXIETY; MEMORY; HUMANS; BEHAVIOR AB Background: Men and women differ in their ability to extinguish fear. Fear extinction requires the activation of brain regions, including the ventromedial prefrontal cortex (vmPFC) and amygdala. Could estradiol modulate the activity of these brain regions during fear extinction? Methods: All rat experiments were conducted in naturally cycling females. Rats underwent fear conditioning on Day 1. On Day 2, they underwent extinction training during the metestrus phase of the cycle (low estrogen and progesterone). Extinction recall was assessed on Day 3. Systemic injections of estrogen receptor-beta and -alpha agonists and of estradiol were administered at different time points to assess their influence on extinction consolidation and c-Fos expression in the vmPFC and amygdala. In parallel, healthy naturally cycling women underwent an analogous fear conditioning extinction training in a 3T functional magnetic resonance scanner. Measurement of their estradiol levels and skin conductance responses were obtained throughout the experiment. Results: In female rats, administration of the estrogen-receptor beta (but not alpha) agonist facilitated extinction recall. Immediate (but not delayed) postextinction training administration of estradiol facilitated extinction memory consolidation and increased c-Fos expression in the vmPFC while reducing it in the amygdala. In parallel, natural variance in estradiol in premenopausal cycling women modulated vmPFC and amygdala reactivity and facilitated extinction recall. Conclusions: We provide translational evidence that demonstrates the influence of endogenous and exogenous estradiol on the fear extinction network. Our data suggest that women's endogenous hormonal status should be considered in future neurobiological research related to anxiety and mood disorders. C1 [Milad, Mohammed R.] Harvard Univ, Dept Psychiat, Sch Med, Charlestown, MA 02129 USA. [Zeidan, Mohamed A.; Igoe, Sarah A.; Linnman, Clas; Vitalo, Antonia; Levine, John B.; Goldstein, Jill M.; Milad, Mohammed R.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Levine, John B.] Massachusetts Gen Hosp, Benson Henry Inst Mind Body Med, Boston, MA 02114 USA. [Levine, John B.] Massachusetts Gen Hosp, Shriners Burns Hosp Children, Boston, MA 02114 USA. [Klibanski, Anne] Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA. [Klibanski, Anne] Harvard Univ, Sch Med, Boston, MA USA. [Goldstein, Jill M.] Brigham & Womens Hosp, Dept Psychiat, Div Womens Hlth, Boston, MA 02115 USA. [Goldstein, Jill M.] Brigham & Womens Hosp, Dept Med, Div Womens Hlth, Boston, MA 02115 USA. RP Milad, MR (reprint author), Harvard Univ, Dept Psychiat, Sch Med, Charlestown, MA 02129 USA. EM milad@nmr.mgh.harvard.edu RI Levine, John/G-6221-2015; OI Linnman, Clas/0000-0001-8449-894X FU National Institute of Mental Health [K01MH080346]; Harvard Clinical and Translational Science Center from the National Center for Research Resources [1UL1 RR025758-01]; John Henry Foundation; Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital; Shriners Burns Hospital for Children, Boston; [ORWH-NIMH P50 MH082679] FX This work was supported by a grant from the National Institute of Mental Health (K01MH080346) to MRM. The project was also supported by Grant No. 1UL1 RR025758-01, Harvard Clinical and Translational Science Center from the National Center for Research Resources, and Grant No. ORWH-NIMH P50 MH082679 (JMG, principal investigator) for JMG's time. JBL was supported by the John Henry Foundation, the Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, and the Medical Research Programs of the Shriners Burns Hospital for Children, Boston. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.; Dr. Mohammed R. Milad received consulting fees from Microtranspondor for a project unrelated to that described in this article. The remaining authors declare no biomedical financial interests or potential conflicts of interest. NR 48 TC 113 Z9 114 U1 2 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD NOV 15 PY 2011 VL 70 IS 10 BP 920 EP 927 DI 10.1016/j.biopsych.2011.05.016 PG 8 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 841DX UT WOS:000296493800005 PM 21762880 ER PT J AU Furmaga, H Shah, A Frazer, A AF Furmaga, Havan Shah, Aparna Frazer, Alan TI Serotonergic and Noradrenergic Pathways Are Required for the Anxiolytic-like and Antidepressant-like Behavioral Effects of Repeated Vagal Nerve Stimulation in Rats SO BIOLOGICAL PSYCHIATRY LA English DT Article DE 5,7-dihydroxytryptamine; 6-hydroxydopamine; desipramine; forced swim test; novelty suppressed feeding test; sertraline; vagal nerve stimulation ID TREATMENT-RESISTANT DEPRESSION; FORCED SWIMMING TEST; VAGUS NERVE; ANXIETY DISORDERS; ANIMAL-MODEL; NOREPINEPHRINE TRANSPORTERS; ANTIINFLAMMATORY CYTOKINES; MEDULLA-OBLONGATA; INDUCED REMISSION; RAPHE NUCLEUS AB Background: Vagal nerve stimulation (VNS) is used for treatment-refractory depression, but there are few preclinical studies of its effects when administered repeatedly over time using clinically relevant stimulation parameters in nonanesthetized animals. Methods: The novelty-suppressed feeding test (NSFT) and forced swim test (FST) were used to evaluate the anxiolytic- and antidepressant-like potential of VNS in rats, respectively. The behavioral effects of VNS were compared with those of desipramine (DMI; 10 mg/kg/day) and sertraline (7.5 mg/kg/day) administered via osmotic minipump. Such experiments were carried out in intact rats as well as those that had selective destruction of either serotonin or noradrenergic neurons in brain caused by the neurotoxins, 5,7-dihyroxytryptamine (5,7-DHT), or 6-hydroxydopamine (6-OHDA). Results: Repeated administration of VNS, DMI, and sertraline decreased latency to feed in the NSFT. In the FST, repeated VNS, DMI, and sertraline caused decreased immobility; the VNS-induced decrease in immobility resulted from increases in both swimming and climbing behaviors. Effects of VNS and sertraline, but not DMI, in both the NSFT and the FST were abolished in rats treated with 5,7-DHT. Effects of DMI in both behavioral tests, but not those of sertraline, were abolished in 6-OHDA treated rats. VNS effects on immobility and climbing in the FST were not blocked in the 6-OHDA-treated rats. There was no significant difference in locomotor activity caused by any of the treatments or by the lesions. Conclusions: Serotonergic nerves are required for repeated VNS-induced anxiolytic- and antidepressant-like effects. Noradrenergic nerves can also be activated by VNS to cause its anxiolytic-like effect. C1 [Furmaga, Havan; Shah, Aparna; Frazer, Alan] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA. [Frazer, Alan] S Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX USA. RP Frazer, A (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, 7703 Floyd Curl Dr,Mail Code 7764, San Antonio, TX 78229 USA. EM frazer@uthscsa.edu FU National Institute of Mental Health [MH082933]; Cyberonics Inc. FX We acknowledge the technical assistance of Mohona Sadhu and thank Dr. David Morilak for his insightful suggestions throughout the course of the experiment. This work was supported by National Institute of Mental Health Grant No. MH082933 (AF). The electrodes, VNS stimulators, and dummy stimulators were gifts from Cyberonics Inc.; Dr. Furmaga and Ms. Shah report no biomedical financial interests or potential conflicts of interest. Dr. Frazer has served on advisory boards for Lundbeck and for Takeda in the last three years. Previously, Dr. Frazer had received financial compensation as a consultant for Cyberonics Inc. and had also obtained grant support from them for a preclinical study. NR 75 TC 24 Z9 24 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD NOV 15 PY 2011 VL 70 IS 10 BP 937 EP 945 DI 10.1016/j.biopsych.2011.07.020 PG 9 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 841DX UT WOS:000296493800007 PM 21907323 ER PT J AU Tang, QZ Chen, YW Meyer, C Geistlinger, T Lupien, M Wang, Q Liu, T Zhang, Y Brown, M Liu, XS AF Tang, Qianzi Chen, Yiwen Meyer, Clifford Geistlinger, Tim Lupien, Mathieu Wang, Qian Liu, Tao Zhang, Yong Brown, Myles Liu, Xiaole Shirley TI A Comprehensive View of Nuclear Receptor Cancer Cistromes SO CANCER RESEARCH LA English DT Article ID MODEL-BASED ANALYSIS; BREAST-CANCER; ANDROGEN RECEPTOR; LIPID-METABOLISM; PROSTATE-CANCER; CHIP-CHIP; INFLAMMATION; ACTIVATION; SIGNATURE; REVEALS AB Nuclear receptors comprise a superfamily of ligand-activated transcription factors that play important roles in both physiology and diseases including cancer. The technologies of chromatin immunoprecipitation followed by array hybridization (ChIP-chip) or massively parallel sequencing (ChIP-seq) has been used to map, at an unprecedented rate, the in vivo genome-wide binding (cistrome) of nuclear receptors in both normal and cancer cells. We developed a curated database of 88 nuclear receptor cistrome data sets and other associated high-throughput data sets including 121 collaborating factor cistromes, 94 epigenomes, and 319 transcriptomes. Through integrative analysis of the curated nuclear receptor ChIP-chip/seq data sets, we discovered novel factor-specific noncanonical motifs that may have important regulatory roles. We also revealed a common feature of nuclear receptor pioneering factors to recognize relatively short and AT-rich motifs. Most nuclear receptors bind predominantly to introns and distal intergenetic regions, and binding sites closer to transcription start sites were found to be neither stronger nor more evolutionarily conserved. Interestingly, while most nuclear receptors appear to be predominantly transcriptional activators, our analysis suggests that the binding of ESR1, RARA, and RARG has both activating and repressive effects. Through meta-analysis of different omic data of the same cancer cell line model from multiple studies, we generated consensus cistrome and expression profiles. We further made probabilistic predictions of the nuclear receptor target genes by integrating cistrome and transcriptome data and validated the predictions using expression data from tumor samples. The final database, with comprehensive cistrome, epigenome, and transcriptome data sets and downstream analysis results, constitutes a valuable resource for the nuclear receptor and cancer community. Cancer Res; 71(22); 6940-7. (C)2011 AACR. C1 [Tang, Qianzi; Wang, Qian; Zhang, Yong] Tongji Univ, Sch Life Sci & Technol, Dept Bioinformat, Shanghai 200092, Peoples R China. [Chen, Yiwen; Meyer, Clifford; Liu, Tao; Liu, Xiaole Shirley] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Geistlinger, Tim; Brown, Myles] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. RP Liu, XS (reprint author), Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Biostat & Computat Biol, 44 Binney St, Boston, MA 02115 USA. EM myles_brown@dfci.harvard.edu; xsliu@jimmy.harvard.edu RI Liu, Tao/G-3585-2010; Zhang, Yong/B-4838-2011; OI Liu, Tao/0000-0002-8818-8313; Zhang, Yong/0000-0001-6316-2734; Liu, Tao/0000-0003-0446-9001; Brown, Myles/0000-0002-8213-1658 FU National Basic Research (973) Program of China [2010CB944904]; NIH [DK062434, DK074967] FX The project was supported by the National Basic Research (973) Program of China No. 2010CB944904 (Q. Tang, Q. Wang, and Y. Zhang) and NIH grants DK062434 (Y. Chen, C. A. Meyer, T. Liu, and X. S. Liu) and DK074967 (T. Geistlinger, M. Lupien, and M. Brown). NR 21 TC 57 Z9 57 U1 2 U2 13 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 2011 VL 71 IS 22 BP 6940 EP 6947 DI 10.1158/0008-5472.CAN-11-2091 PG 8 WC Oncology SC Oncology GA 847NS UT WOS:000296980200005 PM 21940749 ER PT J AU Coen, JJ Bae, K Zietman, AL Patel, B Shipley, WU Slater, JD Rossi, CJ AF Coen, John J. Bae, Kyounghwa Zietman, Anthony L. Patel, Baldev Shipley, William U. Slater, Jerry D. Rossi, Carl J. TI ACUTE AND LATE TOXICITY AFTER DOSE ESCALATION TO 82 GyE USING CONFORMAL PROTON RADIATION FOR LOCALIZED PROSTATE CANCER: INITIAL REPORT OF AMERICAN COLLEGE OF RADIOLOGY PHASE II STUDY 03-12 SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Prostate cancer; Proton radiation; Dose escalation; Dose-volume histogram; Clinical trial ID INTENSITY-MODULATED RADIOTHERAPY; RANDOMIZED CONTROLLED-TRIAL; THERAPY; ADENOCARCINOMA; IRRADIATION AB Purpose: Several randomized trials have shown a benefit of dose escalation to 78 to 79 Gy for men treated with external radiation for localized prostate cancer. Single-institution data suggest a benefit with even higher doses. American College of Radiology 03-12 is a Phase II trial testing the safety and efficacy of 82 GyE (Gray equivalent) delivered with conformal proton radiation. Methods and Materials: From 2003-2006, 85 men with localized prostate cancer were accrued to American College of Radiology 03-12. Eighty-four were eligible for analysis. They were treated with conformal proton radiation alone to a total dose of 82 GyE. The study was designed to test whether the rate of 18-month Grade 3+ late toxicity was greater than 10%. Results: The median follow-up was 31.6 months. Regarding treatment-related acute toxicity, there were 39 Grade 1 cases (46%), 19 Grade 2 cases (23%) and 2 Grade 3 cases (2%). Regarding genitourinary/gastrointestinal toxicity, there were 42 Grade 1 cases (50%), 12 Grade 2 cases (14%) and 1 Grade 3 case (1%). Regarding late toxicity, there were 28 Grade 1 cases (33%), 22 Grade 2 cases (26%), 6 Grade 3 cases (7%), and 1 Grade 4 case (1%). The late genitourinary/gastrointestinal rates were the same. The estimated rate of Grade 3+ late toxicity at 18 months was 6.08%. Conclusions: Although not free of late toxicity, 82 GyE at 2 GyE per fraction delivered with conformal proton radiation did not exceed the late morbidity target tested in this trial. There was sufficient morbidity, however, that this may be the maximal dose that can be delivered safely with this technique and fractionation. (C) 2011 Elsevier Inc. C1 [Coen, John J.; Zietman, Anthony L.; Shipley, William U.] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. [Bae, Kyounghwa] Radiat Therapy Oncol Grp, Dept Stat, Philadelphia, PA USA. [Patel, Baldev; Slater, Jerry D.; Rossi, Carl J.] Loma Linda Univ, Med Ctr, Dept Radiat Oncol, Loma Linda, CA USA. RP Coen, JJ (reprint author), Massachusetts Gen Hosp, Dept Radiat Oncol, 100 Blossom St,Cox 3, Boston, MA 02114 USA. EM jcoen@partners.org NR 16 TC 36 Z9 37 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP 1005 EP 1009 DI 10.1016/j.ijrobp.2010.06.047 PG 5 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 845LG UT WOS:000296823600015 PM 20932675 ER PT J AU Yoon, SS Duda, DG Karl, DL Kim, TM Kambadakone, AR Chen, YL Rothrock, C Rosenberg, AE Nielsen, GP Kirsch, DG Choy, E Harmon, DC Hornicek, FJ Dreyfuss, J Ancukiewicz, M Sahani, DV Park, PJ Jain, RK DeLaney, TF AF Yoon, Sam S. Duda, Dan G. Karl, Daniel L. Kim, Tae-Min Kambadakone, Avinash R. Chen, Yen-Lin Rothrock, Courtney Rosenberg, Andrew E. Nielsen, G. Petur Kirsch, David G. Choy, Edwin Harmon, David C. Hornicek, Francis J. Dreyfuss, Jonathan Ancukiewicz, Marek Sahani, Dushyant V. Park, Peter J. Jain, Rakesh K. DeLaney, Thomas F. TI PHASE II STUDY OF NEOADJUVANT BEVACIZUMAB AND RADIOTHERAPY FOR RESECTABLE SOFT TISSUE SARCOMAS SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Angiogenesis inhibitors; Radiotherapy; Bevacizumab; Biomarkers ID GENE-EXPRESSION; TUMOR RESPONSE; RANDOMIZED TRIAL; RECTAL-CANCER; RADIATION; GROWTH; GRADE; MICROARRAY; EXTREMITY; PERFUSION AB Purpose: Numerous preclinical studies have demonstrated that angiogenesis inhibitors can increase the efficacy of radiotherapy (RT). We sought to examine the safety and efficacy of bevacizumab (BV) and RT in soft tissue sarcomas and explore biomarkers to help determine the treatment response. Methods and Materials: Patients with >= 5 cm, intermediate- or high-grade soft tissue sarcomas at significant risk of local recurrence received neoadjuvant BY alone followed by BY plus RT before surgical resection. Correlative science studies included analysis of the serial blood and tumor samples and serial perfusion computed tomography scans. Results: The 20 patients had a median tumor size of 8.25 cm, with 13 extremity, 1 trunk, and 6 retroperitoneal/pelvis tumors. The neoadjuvant treatment was well tolerated, with only 4 patients having Grade 3 toxicities (hypertension, liver function test elevation). BV plus RT resulted in >= 80 % pathologic necrosis in 9 (45 %) of 20 tumors, more than double the historical rate seen with RT alone. Three patients had a complete pathologic response. The median microvessel density decreased 53% after BY alone (p <.05). After combination therapy, the median tumor cell proliferation decreased by 73%, apoptosis increased 10.4-fold, and the blood flow, blood volume, and permeability surface area decreased by 62-72% (p <.05). Analysis of gene expression microarrays of untreated tumors identified a 24-gene signature for treatment response. The microvessel density and circulating progenitor cells at baseline and the reduction in microvessel density and plasma soluble c-KIT with BV therapy also correlated with a good pathologic response (p <.05). After a median follow-up of 20 months, only 1 patient had developed local recurrence. Conclusions: The results from the present exploratory study indicated that BY increases the efficacy of RT against soft tissue sarcomas and might reduce the incidence of local recurrence. Thus, this regimen warrants additional investigation. Gene expression profiles and other tissue and circulating biomarkers showed promising correlations with treatment response. (C) 2011 Elsevier Inc. C1 [Yoon, Sam S.; Karl, Daniel L.; Rothrock, Courtney] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA. [Duda, Dan G.; Chen, Yen-Lin; Ancukiewicz, Marek; Jain, Rakesh K.; DeLaney, Thomas F.] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA. [Kambadakone, Avinash R.; Sahani, Dushyant V.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Rosenberg, Andrew E.; Nielsen, G. Petur] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Choy, Edwin; Harmon, David C.] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. [Hornicek, Francis J.] Massachusetts Gen Hosp, Dept Orthoped Surg, Boston, MA 02114 USA. [Kim, Tae-Min; Dreyfuss, Jonathan; Park, Peter J.] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA USA. [Kim, Tae-Min; Dreyfuss, Jonathan; Park, Peter J.] Partners Ctr Personalized Genet Med, Boston, MA USA. [Kirsch, David G.] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC USA. [Kirsch, David G.] Duke Univ, Med Ctr, Dept Canc Biol, Durham, NC USA. [Yoon, Sam S.] Univ Penn, Sch Med, Dept Canc Biol, Philadelphia, PA 19104 USA. RP Yoon, SS (reprint author), Massachusetts Gen Hosp, Dept Surg, Yawkey 7B,55 Fruit St, Boston, MA 02114 USA. EM syoon@partners.org OI Choy, Edwin/0000-0001-9896-8084 FU National Institutes of Health/National Cancer Institute [5 K12 CA 87723-03, 1 R21 CA117128-01, U54 LM008748]; Society for Surgical Oncology [R01 CA115767, P01 80124]; Ira J. Spiro Translational Research Award; AstraZeneca; Dyax FX Supported by National Institutes of Health/National Cancer Institute Grants 5 K12 CA 87723-03 (to S. S. Yoon), 1 R21 CA117128-01 (to S. S. Yoon), and U54 LM008748 (P. J. Park), Society for Surgical Oncology Clinical Investigator Award (to S. S. Yoon), R01 CA115767 and P01 80124 (to R. K. Jain), and Ira J. Spiro Translational Research Award (D. G. Duda).; Conflict of interest: R. K. Jain has an advisory role at SynDevRx, Millennium Pharmaceuticals, MorphoSys AG, Regeneron Pharmaceuticals, Genzyme, Dyax, and AstraZeneca; stock ownership in SynDevRx; and has received honoraria from Genzyme and Alnylam and research funding from AstraZeneca and Dyax. D. G. Kirsch has an advisory role at, and stock ownership in, Lumicell Diagnostics. NR 28 TC 34 Z9 34 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP 1081 EP 1090 DI 10.1016/j.ijrobp.2010.07.024 PG 10 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 845LG UT WOS:000296823600026 PM 20932656 ER PT J AU Sperduto, PW Chao, ST Suh, J Sneed, PK Luo, X Roberge, D Bhatt, A Mehta, MP Jensen, AW Brown, PD Shih, H Kirkpatrick, J Gaspar, LE Fiveash, JB Chiang, V Knisely, J Sperduto, CM AF Sperduto, Paul W. Chao, Samuel T. Suh, John Sneed, Penny K. Luo, Xianghua Roberge, David Bhatt, Amit Mehta, Minesh P. Jensen, Ashley W. Brown, Paul D. Shih, Helen Kirkpatrick, John Gaspar, Laurie E. Fiveash, John B. Chiang, Veronica Knisely, Jonathan Sperduto, Christina Maria TI RESPONSE TO "DIAGNOSIS-SPECIFIC PROGNOSTIC FACTORS, INDEXES, AND TREATMENT OUTCOMES FOR PATIENTS WITH NEWLY DIAGNOSED BRAIN METASTASES: A MULTI-INSTITUTIONAL ANALYSIS OF 4,259 PATIENTS." (INT J RADIAT ONCOL BIOL PHYS 2010:77:655-661) REPLY SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Letter C1 [Sperduto, Paul W.] Univ Minnesota, Gamma Knife Ctr, Minneapolis, MN 55455 USA. [Chao, Samuel T.; Suh, John] Cleveland Clin, Dept Radiat Oncol, Cleveland, OH 44106 USA. [Sneed, Penny K.] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA. [Luo, Xianghua] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Roberge, David] McGill Univ, Ctr Hlth, Montreal, PQ, Canada. [Bhatt, Amit; Mehta, Minesh P.] Univ Wisconsin, Dept Human Oncol, Madison, WI USA. [Jensen, Ashley W.; Brown, Paul D.] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA. [Shih, Helen] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. [Kirkpatrick, John] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC USA. [Gaspar, Laurie E.] Univ Colorado, Dept Radiat Oncol, Denver, CO 80202 USA. [Fiveash, John B.] Univ Alabama, Birmingham, AL USA. [Chiang, Veronica] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT USA. [Chiang, Veronica; Knisely, Jonathan] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT USA. [Sperduto, Christina Maria] Minneapolis Radiat Oncol, Minneapolis, MN USA. RP Sperduto, PW (reprint author), Univ Minnesota, Gamma Knife Ctr, Minneapolis, MN 55455 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP 1194 EP 1195 DI 10.1016/j.ijrobp.2010.09.047 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 845LG UT WOS:000296823600045 ER PT J AU Nguyen, PL D'Amico, AV AF Nguyen, Paul L. D'Amico, Anthony V. TI RESPONSE TO "RISK OF ALL-CAUSE AND PROSTATE CANCER-SPECIFIC MORTALITY AFTER BRACHYTHERAPY IN MEN WITH SMALL PROSTATE SIZE" (INT J RADIAT ONCOL BIOL PHYS 2011;79:1318-1322) REPLY SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Letter C1 [Nguyen, Paul L.; D'Amico, Anthony V.] Harvard Univ, Sch Med, Dana Farber Brigham & Womens Canc Ctr, Boston, MA 02215 USA. RP Nguyen, PL (reprint author), Harvard Univ, Sch Med, Dana Farber Brigham & Womens Canc Ctr, Boston, MA 02215 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD NOV 15 PY 2011 VL 81 IS 4 BP 1196 EP 1196 DI 10.1016/j.ijrobp.2011.05.073 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 845LG UT WOS:000296823600047 ER PT J AU Wang, K Wernersson, R Brunak, S AF Wang, Kai Wernersson, Rasmus Brunak, Soren TI The strength of intron donor splice sites in human genes displays a bell-shaped pattern SO BIOINFORMATICS LA English DT Article ID RNA SECONDARY STRUCTURE; U1 SNRNA; HUMAN GENOME; MOUSE; COMPLEMENTARITY; RECOGNITION; VERTEBRATES; ISOCHORES; SEQUENCE; SERVER AB Motivation: The gene concept has recently changed from the classical one protein notion into a much more diverse picture, where overlapping or fused transcripts, alternative transcription initiation, and genes within genes, add to the complexity generated by alternative splicing. Increased understanding of the mechanisms controlling pre-mRNA splicing Results: We have discovered a convex gene delineating pattern in the strength of 5(') intron splice sites. When comparing the strengths of > 18 000 intron containing Human genes, we found that when analysing them separately according to the number of introns they contain, initial splice sites were always stronger on average than subsequent ones, and that a similar reversed trend exist towards the terminal gene part. The convex pattern is strongest for genes with up to 10 introns. Interestingly, when analysing the intron containing gene pool from mouse consisting of > 15 000 genes, we found the convex pattern to be conserved despite > 75 million years of evolutionary divergence between the two organisms. We also analysed an interesting, novel class of chimeric genes which during spliceosome assembly are fused and in tandem are transcribed and spliced into a single mature mRNA sequence. In their splice site patterns, these genes individually seem to deviate from the convex pattern, offering a possible rationale behind their fusion into a single transcript. C1 [Wang, Kai; Wernersson, Rasmus; Brunak, Soren] Tech Univ Denmark, Ctr Biol Sequence Anal, Dept Syst Biol, DK-2800 Lyngby, Denmark. [Wang, Kai] Harvard Univ, Dept Biostat & Computat Biol, Dana Farber Canc Inst, Harvard Sch Publ Hlth, Boston, MA 02115 USA. [Wang, Kai] Harvard Univ, Dept Radiol, Harvard Med Sch, Boston, MA 02115 USA. RP Brunak, S (reprint author), Tech Univ Denmark, Ctr Biol Sequence Anal, Dept Syst Biol, DK-2800 Lyngby, Denmark. EM brunak@cbs.dtu.dk FU Danish National Research Foundation; Natural Science Research Council of Denmark FX Danish National Research Foundation; Natural Science Research Council of Denmark. NR 32 TC 0 Z9 0 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1367-4803 J9 BIOINFORMATICS JI Bioinformatics PD NOV 15 PY 2011 VL 27 IS 22 BP 3079 EP 3084 DI 10.1093/bioinformatics/btr532 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Computer Science; Mathematical & Computational Biology; Mathematics GA 842YG UT WOS:000296637500001 PM 21994226 ER PT J AU Schroder, MS Culhane, AC Quackenbush, J Haibe-Kains, B AF Schroeder, Markus S. Culhane, Aedin C. Quackenbush, John Haibe-Kains, Benjamin TI survcomp: an R/Bioconductor package for performance assessment and comparison of survival models SO BIOINFORMATICS LA English DT Article ID BREAST-CANCER PROGNOSTICATION AB The survcomp package provides functions to assess and statistically compare the performance of survival/risk prediction models. It implements state-of-the-art statistics to (i) measure the performance of risk prediction models; (ii) combine these statistical estimates from multiple datasets using a meta-analytical framework; and (iii) statistically compare the performance of competitive models. C1 [Schroeder, Markus S.; Culhane, Aedin C.; Quackenbush, John; Haibe-Kains, Benjamin] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02215 USA. RP Schroder, MS (reprint author), Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02215 USA. EM mschroed@jimmy.harvard.edu; bhaibeka@jimmy.harvard.edu RI Haibe-Kains, Benjamin/D-3702-2011 OI Haibe-Kains, Benjamin/0000-0002-7684-0079 FU National Human Genome Research Institute [1P50 HG004233]; Fulbright Commission for Educational Exchange; US National Institutes of Health [R01 LM010129-01]; Claudia Adams Barr Program in Innovative Basic Cancer Research; DFCI Breast Cancer SPORE [CA 08939] FX National Human Genome Research Institute (1P50 HG004233, to M.S.S.); Fulbright Commission for Educational Exchange to (B.H.-K.); US National Institutes of Health (R01 LM010129-01, to B.H.-K. and J.Q.); Claudia Adams Barr Program in Innovative Basic Cancer Research (A.C.C. and J.Q.); Career Development grant (to A.C.C.) from DFCI Breast Cancer SPORE: CA 08939. NR 18 TC 53 Z9 55 U1 1 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1367-4803 J9 BIOINFORMATICS JI Bioinformatics PD NOV 15 PY 2011 VL 27 IS 22 BP 3206 EP 3208 DI 10.1093/bioinformatics/btr511 PG 3 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Computer Science; Mathematical & Computational Biology; Mathematics GA 842YG UT WOS:000296637500021 PM 21903630 ER PT J AU Howe, EA Sinha, R Schlauch, D Quackenbush, J AF Howe, Eleanor A. Sinha, Raktim Schlauch, Daniel Quackenbush, John TI RNA-Seq analysis in MeV SO BIOINFORMATICS LA English DT Article ID DIFFERENTIAL EXPRESSION ANALYSIS; ALIGNMENT; PACKAGE; BIAS; TM4 AB RNA-Seq is an exciting methodology that leverages the power of high-throughput sequencing to measure RNA transcript counts at an unprecedented accuracy. However, the data generated from this process are extremely large and biologist-friendly tools with which to analyze it are sorely lacking. MultiExperiment Viewer (MeV) is a Java-based desktop application that allows advanced analysis of gene expression data through an intuitive graphical user interface. Here, we report a significant enhancement to MeV that allows analysis of RNA-Seq data with these familiar, powerful tools. We also report the addition to MeV of several RNA-Seq-specific functions, addressing the differences in analysis requirements between this data type and traditional gene expression data. These tools include automatic conversion functions from raw count data to processed RPKM or FPKM values and differential expression detection and functional annotation enrichment detection based on published methods. C1 [Howe, Eleanor A.; Sinha, Raktim; Schlauch, Daniel; Quackenbush, John] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Howe, Eleanor A.] Univ Oxford, Dept Stat, Oxford OX1 3TG, England. [Quackenbush, John] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. [Quackenbush, John] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. RP Quackenbush, J (reprint author), Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. EM johnq@jimmy.harvard.edu FU National Library of Medicine of the US National Institute of Health [1R01LM008795-01] FX National Library of Medicine of the US National Institute of Health (1R01LM008795-01). NR 14 TC 53 Z9 55 U1 3 U2 19 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1367-4803 EI 1460-2059 J9 BIOINFORMATICS JI Bioinformatics PD NOV 15 PY 2011 VL 27 IS 22 BP 3209 EP 3210 DI 10.1093/bioinformatics/btr490 PG 2 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Computer Science; Mathematical & Computational Biology; Mathematics GA 842YG UT WOS:000296637500022 PM 21976420 ER PT J AU Gupta, K Hooton, TM Miller, L AF Gupta, Kalpana Hooton, Thomas M. Miller, Loren CA Uncomplicated UTI IDSA Guideline TI Managing Uncomplicated Urinary Tract Infection-Making Sense Out of Resistance Data SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID MICROBIOLOGY; CYSTITIS C1 [Gupta, Kalpana] Vet Affairs Boston Healthcare Syst, Dept Med, Boston, MA USA. [Gupta, Kalpana] Boston Univ, Sch Med, Boston, MA 02215 USA. [Hooton, Thomas M.] Univ Miami, Dept Med, Coral Gables, FL 33124 USA. [Miller, Loren] Harbor UCLA Med Ctr, Dept Med, Torrance, CA 90509 USA. RP Gupta, K (reprint author), VA Boston Hlth Care Syst, Dept Med, 1400 VFW