FN Thomson Reuters Web of Science™ VR 1.0 PT J AU ROSOWSKY, A FORSCH, RA MORAN, RG AF ROSOWSKY, A FORSCH, RA MORAN, RG TI FOLIC-ACID ANALOGS LACKING THE 2-CARBON ARE SUBSTRATES FOR FOLYLPOLYGLUTAMATE SYNTHETASE AND INHIBIT CELL-GROWTH SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Letter ID LIVER FOLYPOLYGLUTAMATE SYNTHETASE; STRUCTURALLY RELATED PTERIDINE; DIHYDROFOLATE-REDUCTASE; PYRIMIDINE ANALOGS; AMINOPTERIN; METHOTREXATE; QUINAZOLINE C1 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. NORRIS COMPREHENS CANC CTR,CANC RES LABS,LOS ANGELES,CA 90021. RP ROSOWSKY, A (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115, USA. FU NCI NIH HHS [R01-CA39867] NR 16 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JAN PY 1991 VL 34 IS 1 BP 461 EP 463 DI 10.1021/jm00105a070 PG 3 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA ET545 UT WOS:A1991ET54500070 PM 1992148 ER PT J AU CARROLL, JM KIM, KS KIM, KT GOODMAN, HM JOH, TH AF CARROLL, JM KIM, KS KIM, KT GOODMAN, HM JOH, TH TI EFFECTS OF 2ND MESSENGER SYSTEM ACTIVATION ON FUNCTIONAL EXPRESSION OF TYROSINE-HYDROXYLASE FUSION GENE CONSTRUCTS IN NEURONAL AND NONNEURONAL CELLS SO JOURNAL OF MOLECULAR NEUROSCIENCE LA English DT Article ID PHENYLETHANOLAMINE N-METHYLTRANSFERASE; DEPENDENT PROTEIN-KINASE; AMP RESPONSE ELEMENT; NUCLEAR FACTOR CREB; CYCLIC-AMP; DNA ELEMENTS; TRANSCRIPTION FACTOR; CHROMAFFIN CELLS; PRIMARY CULTURES; CAMP AB A genomic clone for rat tyrosine hydroxylase (TH) was isolated and a fragment containing 503 bp upstream of the transcription start site was sequenced. The BamHI/AluI fragment was inserted into a plasmid carrying the coding sequence for bacterial chloramphenicol acetyltransferase (CAT). Another construct with the 5' sequence truncated to -151 bp also was prepared. When these were introduced into several mammalian cell lines, including C6 glioma, BE(2) neuroblastoma, CV-1 or Ltk- fibroblasts, different basal levels of CAT expression were observed. In the fibroblast lines, THCAT constructs were not expressed unless the cells were treated with forskolin or TPA. However, the low basal expression was not correlated to endogenous expression as THCAT constructs expressed comparably in BE(2)C, HeLa, and C6 glioma. Treatment of any of the cell lines with forskolin, TPA, or a combination of the two agents stimulated the expression by at least two-fold in all cell lines and the maximally induced levels were at least 10-fold over promoterless controls. These data indicate that the essential promoter elements as well as those conferring responsivity to cyclic AMP reside within 151 bp of the transcription start site. However, the array of elements regulating cell-type expression lie, at least in part, beyond the 500-bp region examined. Further, a role for phosphorylation in the regulation of basal and induced transcription of TH is suggested. C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. RP CARROLL, JM (reprint author), CORNELL UNIV,COLL MED,MED RES INST BURKE,MOLEC NEUROBIOL LAB,785 MAMARONECK AVE,WHITE PLAINS,NY 10605, USA. FU NIMH NIH HHS [MH24285] NR 46 TC 28 Z9 28 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 SN 0895-8696 J9 J MOL NEUROSCI JI J. Mol. Neurosci. PY 1991 VL 3 IS 2 BP 65 EP 74 DI 10.1007/BF02885527 PG 10 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA GK610 UT WOS:A1991GK61000002 PM 1687657 ER PT J AU CARROLL, JM EVINGER, MJ GOODMAN, HM JOH, TH AF CARROLL, JM EVINGER, MJ GOODMAN, HM JOH, TH TI DIFFERENTIAL AND COORDINATE REGULATION OF TH AND PNMT MESSENGER-RNAS IN CHROMAFFIN CELL-CULTURES BY 2ND MESSENGER SYSTEM ACTIVATION AND STEROID TREATMENT SO JOURNAL OF MOLECULAR NEUROSCIENCE LA English DT Article ID PHENYLETHANOLAMINE N-METHYLTRANSFERASE; NERVE GROWTH-FACTOR; RAT TYROSINE-HYDROXYLASE; DEPENDENT PROTEIN-KINASE; ADRENAL-MEDULLARY CELLS; AMP RESPONSE ELEMENT; CYCLIC-AMP; SYMPATHETIC NEURONS; PHOSPHORYLATION SITES; PHORBOL ESTER AB Primary cultures of chromaffin cells were prepared from bovine adrenal medullae and the levels of mRNA for tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) determined. The cells expressed moderate levels of TH mRNA and low levels of PNMT mRNA. The latter appeared to be more sensitive than TH mRNA to variations in the culture medium. The treatment of cultures with agents that activate signal transduction pathways, forskolin or phorbol esters, dramatically enhanced the expression of both mRNAs. The forskolin-induced increases in the steady-state levels of TH and PNMT mRNAs occurred rapidly and were apparent within 5 hours. These data suggest that the TH and PNMT genes can be regulated by second messengers. In contrast, dexamethasone treatment dramatically increased PNMT mRNA with no change in TH mRNA. The increase in PNMT mRNA was apparent within 6 hours of addition of the drug to the culture medium. C1 CORNELL UNIV,MED CTR,COLL MED,DIV NEUROBIOL,NEW YORK,NY 10021. MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. RP CARROLL, JM (reprint author), CORNELL UNIV,COLL MED,BURKE MED RES INST,MOLEC NEUROBIOL LAB,785 MAMARONECK AVE,WHITE PLAINS,NY 10605, USA. FU NIMH NIH HHS [MH24285] NR 59 TC 39 Z9 39 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 SN 0895-8696 J9 J MOL NEUROSCI JI J. Mol. Neurosci. PY 1991 VL 3 IS 2 BP 75 EP 83 DI 10.1007/BF02885528 PG 9 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA GK610 UT WOS:A1991GK61000003 PM 1726044 ER PT J AU ARESO, MP FRAZER, A AF ARESO, MP FRAZER, A TI EFFECT OF REPEATED ADMINISTRATION OF NOVEL STRESSORS ON CENTRAL BETA-ADRENOCEPTORS SO JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION LA English DT Note DE STRESS; BETA-ADRENOCEPTORS; AMYGDALA ID RAT-BRAIN; NORADRENALINE RELEASE; ADRENERGIC-RECEPTORS; QUANTITATIVE AUTORADIOGRAPHY; H-3 DIHYDROALPRENOLOL; LOCUS COERULEUS; SEROTONIN; REDUCTION; AMYGDALA; REGIONS AB Subtypes of beta adrenoceptors were measured in 17 different areas of brain in rats exposed for 12 days to novel stressors. Mild stress such as individual housing and handling caused no change in beta1 and beta2 adrenoceptors in comparison with that measured in rats that were group housed and never handled. Exposure of rats to more severe stressors did reduce significantly the binding of I-125-iodopindolol (I-125-IPIN) to beta1 adrenoceptors, but not beta2 adrenoceptors, only in the lateral and basolateral nuclei of the amygdala. C1 UNIV PENN,SCH MED,DEPT PHARMACOL,PHILADELPHIA,PA 19104. UNIV PENN,SCH MED,DEPT PSYCHIAT,PHILADELPHIA,PA 19104. RP ARESO, MP (reprint author), DEPT VET AFFAIRS MED CTR,ISIE,NEUROPSYCHOPHARMACOL UNIT,PHILADELPHIA,PA 19104, USA. FU NIMH NIH HHS [MH 29094] NR 36 TC 16 Z9 16 U1 0 U2 0 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0300-9564 J9 J NEURAL TRANSM-GEN JI J. Neural Transm.-Gen. Sect. PY 1991 VL 86 IS 3 BP 229 EP 235 DI 10.1007/BF01250709 PG 7 WC Neurosciences SC Neurosciences & Neurology GA GQ473 UT WOS:A1991GQ47300008 PM 1685653 ER PT J AU MURPHY, DL SIMS, KB KAROUM, F GARRICK, NA DELACHAPELLE, A SANKILA, EM NORIO, R BREAKEFIELD, XO AF MURPHY, DL SIMS, KB KAROUM, F GARRICK, NA DELACHAPELLE, A SANKILA, EM NORIO, R BREAKEFIELD, XO TI PLASMA AMINE OXIDASE ACTIVITIES IN NORRIE DISEASE PATIENTS WITH AN X-CHROMOSOMAL DELETION AFFECTING MONOAMINE-OXIDASE SO JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION LA English DT Article DE BENZYLAMINE; DOPAMINE; SEROTONIN; GENETICS ID INHIBITOR-RELATED CHARACTERISTICS; VASCULAR SMOOTH-MUSCLE; BENZYLAMINE OXIDASE; CEREBROSPINAL-FLUID; RAT-BRAIN; CLORGYLINE; METABOLITES; SUBSTRATE; GENE; CATECHOLAMINES AB Two individuals with an X-chromosomal deletion were recently found to lack the genes encoding monoamine oxidase type A (MAO-A) and MAO-B. This abnormality was associated with almost total (90%) reductions in the oxidatively deaminated urinary metabolites of the MAO-A substrate, norepinephrine, and with marked (100-fold) increases in an MAO-B substrate, phenylethylamine, confirming systemic functional consequences of the genetic enzyme deficiency. However, urinary concentrations of the deaminated metabolites of dopamine and serotonin (5-HT) were essentially normal. To investigate other deaminating systems besides MAO-A and MAO-B that might produce these metabolites of dopamine and 5-HT, we examined plasma amine oxidase (AO) activity in these two patients and two additional patients with the same X-chromosomal deletion. Normal plasma AO activity was found in all four Norrie disease-deletion patients, in four patients with classic Norrie disease without a chromosomal deletion, and in family members of patients from both groups. Marked plasma amine metabolite abnormalities and essentially absent platelet MAO-B activity were found in all four Norrie disease-deletion patients, but in none of the other subjects in the two comparison groups. These results indicate that plasma AO is encoded by gene(s) independent of those for MAO-A and MAO-B, and raise the possibility that plasma AO, and perhaps the closely related tissue AO, benzylamine oxidase, as well as other atypical AOs or MAOs encoded independently from MAO-A and MAO-B may contribute to the oxidative deamination of dopamine and 5-HT in humans. C1 EUNICE KENNEDY SHRIVER CTR MENTAL RETARDAT INC,DIV MOLEC NEUROGENET,WALTHAM,MA. MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET UNIT NEUROL,BOSTON,MA 02114. NIMH,ST ELIZABETHS HOSP,CTR NEUROSCI,WASHINGTON,DC 20032. UNIV HELSINKI,DEPT MED GENET,SF-00100 HELSINKI 10,FINLAND. VAESTOELIITTO,DEPT MED GENET,HELSINKI,FINLAND. HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BOSTON,MA 02115. RP MURPHY, DL (reprint author), NIMH,CLIN SCI LAB,CTR CLIN,10-3D41,BETHESDA,MD 20892, USA. FU NICHD NIH HHS [HD00824]; NINDS NIH HHS [NS21921] NR 57 TC 29 Z9 32 U1 0 U2 0 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0300-9564 J9 J NEURAL TRANSM-GEN JI J. Neural Transm.-Gen. Sect. PY 1991 VL 83 IS 1-2 BP 1 EP 12 DI 10.1007/BF01244447 PG 12 WC Neurosciences SC Neurosciences & Neurology GA ER309 UT WOS:A1991ER30900001 PM 2018626 ER PT J AU MOSKOWITZ, MA BUZZI, MG AF MOSKOWITZ, MA BUZZI, MG TI NEUROEFFECTOR FUNCTIONS OF SENSORY FIBERS - IMPLICATIONS FOR HEADACHE MECHANISMS AND DRUG ACTIONS SO JOURNAL OF NEUROLOGY LA English DT Article; Proceedings Paper CT SATELLITE SYMP TO THE 2ND MEETING OF THE EUROPEAN NEUROLOGICAL SOC : MIGRAINE IN THE 90S CY JUL 05, 1990 CL BRIGHTON, ENGLAND SP EUROPEAN NEUROL SOC DE VASODILATATION; PLASMA EXTRAVASATION; NEUROGENIC INFLAMMATION; ANTIMIGRAINE DRUGS ID SUBSTANCE-P; VASCULAR-PERMEABILITY; GUINEA-PIG; DURA MATER; CAPSAICIN; THERMOCOAGULATION; EXTRAVASATION; GANGLION; GR43175; RELEASE AB The results of recent investigations designed to elucidate the neuroeffector functions of sensory fibres, the cause of migraine headache and the mechanism of action of antimigraine drugs are reviewed and discussed. Neurogenic inflammation (vasodilatation and neurogenic plasma extravasation) is one explanation for the development of headaches and the blood flow changes which occur during migraine headache. Numerous studies have recently been carried out on rats and guinea-pigs into the effects of antimigraine agents, including ergot alkaloids, sumatriptan and non-steroidal anti-inflammatory drugs (NSAIDs), on neurogenic plasma protein extravasation in the dura mater induced by electrical stimulation of trigeminal ganglia or systemic administration of capsaicin. It is known that the dura mater is able to produce headaches in man. Ergot alkaloids have been shown to block neurogenic inflammation via a C-fibre dependent neuronal mechanism. Sumatriptan appears to act fairly similarly although, whereas the ergot alkaloids are non-selective for either 5-hydroxytryptamine (5-HT; serotonin) receptors or 5-HT1, sumatriptan is selective for 5-HT1 receptors. The antimigraine action of NSAIDs may be via either an effect on blood vessels or an effect on the nerve fibre. The antimigraine effects of ergot alkaloids, sumatriptan and NSAIDs are discussed in the light of the common vasoconstrictor actions of these agents and knowledge that vasodilatation is apparently not responsible for migraine headache pain in most cases. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROSURG,BOSTON,MA 02114. RP MOSKOWITZ, MA (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,STROKE RES LAB,BOSTON,MA 02114, USA. NR 29 TC 54 Z9 54 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-5354 J9 J NEUROL JI J. Neurol. PY 1991 VL 238 SU 1 BP S18 EP S22 DI 10.1007/BF01642901 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA FB539 UT WOS:A1991FB53900005 PM 2045826 ER PT J AU BEAL, MF SWARTZ, KJ FINN, SF MAZUREK, MF KOWALL, NW AF BEAL, MF SWARTZ, KJ FINN, SF MAZUREK, MF KOWALL, NW TI NEUROCHEMICAL CHARACTERIZATION OF EXCITOTOXIN LESIONS IN THE CEREBRAL-CORTEX SO JOURNAL OF NEUROSCIENCE LA English DT Article ID NADPH-DIAPHORASE NEURONS; HUNTINGTONS-DISEASE; QUINOLINIC ACID; NEUROPEPTIDE-Y; ALZHEIMERS-DISEASE; URIC-ACID; STRIATAL NEURONS; RAT STRIATUM; SELECTIVELY RESISTANT; HIPPOCAMPAL-FORMATION AB Neuronal degeneration that occurs in both ischemia and degenerative neurologic illnesses may involve excitotoxic mechanisms. In the present study, we examined whether cortical lesions with agonists acting at subtypes of glutamate receptors result in selective patterns of neuronal death. Injections of quinolinic acid, NMDA, homocysteic acid, kainic acid (KA), and alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) were made at 2 sites in the dorsolateral frontoparietal cortex in rats. After 1 week, the cerebral cortex was either dissected for neurochemical studies, or animals were perfused for histologic evaluation. Concentrations of somatostatin (SS), neuropeptide Y (NPY), substance P (SP), cholecystokinin (CCK), and vasoactive intestinal polypeptide (VIP) were measured by radioimmunoassay, while amino acids and catecholamines were measured by high-performance liquid chromatography (HPLC) with electrochemical detection. NMDA agonists (quinolinic acid, homocysteic acid, and NMDA itself) resulted in dose-dependent reductions in glutamate and GABA, while SS, NPY, SP, CCK, and VIP were either unchanged or significantly increased in concentration. KA and AMPA at doses that resulted in comparable GABA depletions caused significant reductions in SS concentrations. Markers of cortical afferents were spared. All excitotoxins resulted in dose-dependent marked increases in uric acid concentrations. Histologic examination verified that lesions with NMDA agonists produced relative sparing of NADPH-diaphorase, SS, VIP, and CCK neurons. These results show that NMDA excitotoxin lesions result in a pattern of selective neuronal damage in the cerebral cortex that is similar to that which occurs in both ischemia and Huntington's disease. C1 HARVARD UNIV, SCH MED, PROGRAM NEUROSCI, BOSTON, MA 02114 USA. MCMASTER UNIV, MED CTR, DEPT MED, DIV NEUROL, HAMILTON L8N 3Z5, ONTARIO, CANADA. RP BEAL, MF (reprint author), MASSACHUSETTS GEN HOSP, NEUROL SERV, NEUROCHEM LAB, NEUROL RES 4, BOSTON, MA 02114 USA. RI Kowall, Neil/G-6364-2012 OI Kowall, Neil/0000-0002-6624-0213 FU NINDS NIH HHS [NS10828-14A1]; PHS HHS [16367] NR 65 TC 84 Z9 86 U1 0 U2 0 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD JAN PY 1991 VL 11 IS 1 BP 147 EP 158 PG 12 WC Neurosciences SC Neurosciences & Neurology GA ER417 UT WOS:A1991ER41700012 PM 1670782 ER PT J AU GELLER, AI AF GELLER, AI TI A SYSTEM, USING NEURAL CELL-LINES, TO CHARACTERIZE HSV-1 VECTORS CONTAINING GENES WHICH AFFECT NEURONAL PHYSIOLOGY, OR NEURONAL PROMOTERS SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE HSV-1 VECTORS; NEURAL CELL LINES; NEURONAL PHYSIOLOGY; REGULATION OF GENE EXPRESSION; GENE THERAPY ID SIMPLEX VIRUS TYPE-1; NEUROTRANSMITTER SYNTHESIS; DNA; RETROVIRUS; REGION; GENOME; SEQUENCES; FRAGMENTS; MUTANTS; CLONES AB Among the potential uses of defective herpes simplex virus (HSV-1) vectors are to study neuronal physiology, neuronal gene regulation, and to perform gene therapy of neuronal diseases. The prototype HSV-1 vector, pHSVlac, stably expresses Escherichia coli beta-galactosidase from the HSV-1 immediate early (IE) 4/5 promoter in cultured rat peripheral and CNS neurons, and in neurons in the adult rat brain. The LacZ gene and the IE 4/5 promoter in pHSVlac can be replaced with genes which affect neuronal physiology or cellular promoters, respectively. A system is required to characterize these HSV-1 vectors; cultured neurons, a mixture of different kinds of neurons and glia, cannot be used. In contrast, neural cell lines represent a homogenous population of neural cells available in virtually unlimited quantities. A system, using neural cell lines, to characterize HSV-1 vectors carrying other genes or promoters is now reported: First, 4 assays are described to detect HSV-1 vector DNA, RNA transcribed from the vector, and to quantitate beta-galactosidase expression. Second, 8 cell lines derived from rodents, primates, and humans were infected with pHSVlac virus and shown to express beta-galactosidase. The cell lines tested included adrenergic and cholinergic mouse neuroblastoma cells, rat pheochromocytoma cells, rodent pituicytes, and human neuroblastoma cells. Infection of these cell lines should prove useful for characterizing HSV-1 vectors with molecular and biochemical assays. Third, differentiated rat pheochromocytoma and mouse neuroblastoma cells, which resemble neurons, were infected with pHSVlac virus and shown to stably express beta-galactosidase. Infection of these cells should be useful for determining the effect of various HSV-1 vectors on neuronal physiology. Thus, HSV-1 vectors containing various genes or promoters can be characterized using the system described in this study. C1 MASSACHUSETTS GEN HOSP,DEPT NEUROL,NEUROGENET LAB,BOSTON,MA 02114. EUNICE KENNEDY SHRIVER,DIV MOLEC NEUROGENET,WALTHAM,MA 02254. RI Geller, Alfred/C-6469-2012 FU NIDDK NIH HHS [DK39836] NR 37 TC 12 Z9 12 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD JAN PY 1991 VL 36 IS 1 BP 91 EP 103 DI 10.1016/0165-0270(91)90142-M PG 13 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA EZ940 UT WOS:A1991EZ94000012 PM 1648153 ER PT J AU KIM, TS HALLIDAY, AL HEDLEYWHYTE, ET CONVERY, K AF KIM, TS HALLIDAY, AL HEDLEYWHYTE, ET CONVERY, K TI CORRELATES OF SURVIVAL AND THE DAUMAS-DUPORT GRADING SYSTEM FOR ASTROCYTOMAS SO JOURNAL OF NEUROSURGERY LA English DT Article DE ASTROCYTOMA; GRADING SYSTEM; OUTCOME; NUCLEAR ATYPIA; MITOSIS; ENDOTHELIAL PROLIFERATION; NECROSIS ID GLIOBLASTOMA-MULTIFORME; PROGNOSTIC IMPLICATIONS; ANAPLASTIC ASTROCYTOMA; HISTOLOGIC FEATURES; GLIOMAS; SUPRATENTORIAL AB In order to examine the correlation between prognosis and the histological features of nuclear atypia, mitosis, endothelial proliferation, and necrosis in supratentorial adult astrocytomas, the authors reviewed 251 such cases treated at the Massachusetts General Hospital between 1972 and 1980. One point was given for the presence of each feature. The total number of features was translated into a grade as follows: none of the four features = Grade 1 (one patient), one feature = Grade 2 (36 patients), two features = Grade 3 (33 patients), and three or four features = Grade 4 (181 patients). The period of survival was significantly associated with grade, the presence or absence of each of the four histological features, patient's age, type of operation, radiation therapy, and extent of tumor (log rank, p < 0.05). The variables associated with grade were age (p < 0.001) and radiation therapy (p < 0.02). After adjustment for these variables using a Cox proportional-hazards model, the difference in overall survival time between patients in Grades 2 and 3 was not statistically significant. When comparable groups of patients were examined in terms of age or receipt of radiation therapy, the median survival times differed markedly. Patients 50 years of age or less had a median survival time of 68 months (Grade 2 tumors), 29 months (Grade 3 tumors), and 13 months (Grade 4 tumors). Patients over 50 years of age had a median survival time of 6 months (Grade 2 and 4 tumors) and 9 months (Grade 3 tumors). Those patients who had received radiation therapy had a median survival time of 68 months (Grade 2 tumors), 21 months (Grade 3 tumors), and 11 months (Grade 4 tumors). Those patients who did not receive radiation therapy had a median survival time of 1 month (Grade 2 tumors) and 2 months (Grade 3 and 4 tumors); over half of these patients died within 2 months of surgery. This grading system, originally proposed by Daumas-Duport, et al., is simple, objective, and reproducible, and correlates well with survival times. The authors recommend that astrocytomas be graded on a scale of 1 to 4, with Grade 1 reserved for the rare adult supratentorial astrocytoma with none of the four histological features. C1 MASSACHUSETTS GEN HOSP,DEPT PATHOL NEUROPATHOL,NEUROPATHOL LAB,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT RADIAT MED,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 41 TC 131 Z9 132 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD JAN PY 1991 VL 74 IS 1 BP 27 EP 37 DI 10.3171/jns.1991.74.1.0027 PG 11 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA EP617 UT WOS:A1991EP61700005 PM 1984503 ER PT J AU STEICHEN, JD WEISS, MJ ELMALEH, DR MARTUZA, RL AF STEICHEN, JD WEISS, MJ ELMALEH, DR MARTUZA, RL TI ENHANCED INVITRO UPTAKE AND RETENTION OF H-3 TETRAPHENYLPHOSPHONIUM BY NERVOUS-SYSTEM TUMOR-CELLS SO JOURNAL OF NEUROSURGERY LA English DT Article DE PHOTODYNAMIC THERAPY; CENTRAL NERVOUS SYSTEM NEOPLASM; TUMOR MARKER; LIPOPHILIC CATIONIC COMPOUND ID CARCINOMA-CELLS; RHODAMINE-123; SURVIVAL; THERAPY; GLIOMA; RAT; MITOCHONDRIAL; ACCUMULATION; PHOTOLYSIS AB Photodynamic therapy is a promising treatment for human brain tumors because of the selective retention of certain compounds by tumor cells. Certain lipophilic cationic compounds, such as tetraphenylphosphonium (TPP), are selectively taken up by a variety of carcinomas. Although preferential retention of TPP has been demonstrated for the breast carcinoma cell line MCF-7, this compound had not been tested previously on cells derived from nervous system tumors. In the present study, tritiated-TPP (H-3-TPP) uptake and retention for eight different cell cultures of three histologically different types of nervous system tumors was measured and the data were compared to a positive control (MCF-7) and negative controls (normal African Green monkey kidney epithelium (CV-1) and the normal human fibroblast (WI-38) cell lines). Uptake and retention characteristics could be grouped by specific pathological tumor types, but individual tumor variability was notable. Malignant astrocytoma (grade III/III glioblastoma) and malignant neurofibrosarcoma cells showed preferential uptake and retention of H-3-TPP relative to meningioma cells and normal controls. A clonogenic assay utilizing the cytotoxic lipophilic cationic compound dequalinium showed strong retainers of H-3-TPP to be more susceptible to the effects of dequalinium than weak retainers. These data demonstrate that certain human and experimental animal nervous system tumor cell lines retain lipophilic compounds possessing a delocalized positive charge. Lipophilic cationic compounds may be useful in the intraoperative delineation of tumor margins and in the photodynamic therapy of certain nervous system tumors. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL,BOSTON,MA 02114. RP STEICHEN, JD (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT SURG,NEUROSURG SERV,ACC-312,FRUIT ST,BOSTON,MA 02114, USA. NR 21 TC 29 Z9 29 U1 0 U2 3 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD JAN PY 1991 VL 74 IS 1 BP 116 EP 122 DI 10.3171/jns.1991.74.1.0116 PG 7 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA EP617 UT WOS:A1991EP61700019 PM 1984490 ER PT J AU LOUIS, DN HAMILTON, AJ SOBEL, RA OJEMANN, RG AF LOUIS, DN HAMILTON, AJ SOBEL, RA OJEMANN, RG TI PSEUDOPSAMMOMATOUS MENINGIOMA WITH ELEVATED SERUM CARCINOEMBRYONIC ANTIGEN - A TRUE SECRETORY MENINGIOMA - CASE-REPORT SO JOURNAL OF NEUROSURGERY LA English DT Article DE MENINGIOMA; CARCINOEMBRYONIC ANTIGEN; PSEUDOPSAMMOMA BODY; CENTRAL NERVOUS SYSTEM TUMOR ID CEREBROSPINAL-FLUID; TUMORS; BODIES AB A sphenoid-wing meningioma in a 60-year-old woman was accompanied by elevated serum carcinoembryonic antigen (CEA) levels, which returned to normal after removal of the tumor. Light microscopic examination revealed a secretory meningioma containing numerous pseudopsammoma bodies and a prominent vascular pattern. Immunohistochemical analysis showed the tumor cells and pseudopsammoma bodies to be CEA-positive. This case illustrates the possibility that secretory meningioma may be associated with clinically detectable secretion of CEA. The report also documents the rare occurrence of elevated serum CEA in a primary benign intracranial tumor. C1 MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP LOUIS, DN (reprint author), MASSACHUSETTS GEN HOSP,DEPT PATHOL NEUROPATHOL,WARREN 3,BOSTON,MA 02114, USA. NR 15 TC 27 Z9 28 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD JAN PY 1991 VL 74 IS 1 BP 129 EP 132 DI 10.3171/jns.1991.74.1.0129 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA EP617 UT WOS:A1991EP61700021 PM 1984492 ER PT J AU JANDINSKI, JJ STASHENKO, P FEDER, LS LEUNG, CC PEROS, WJ RYNAR, JE DEASY, MJ AF JANDINSKI, JJ STASHENKO, P FEDER, LS LEUNG, CC PEROS, WJ RYNAR, JE DEASY, MJ TI LOCALIZATION OF INTERLEUKIN-1-BETA IN HUMAN PERIODONTAL TISSUE SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE INTERLEUKIN-1-BETA; PERIODONTAL DISEASES PATHOGENESIS ID THYMOCYTE-ACTIVATING FACTOR; HUMAN GINGIVAL FIBROBLASTS; TUMOR NECROSIS FACTOR; T-CELL ACTIVATION; BONE-RESORPTION; MACROPHAGES; INDUCTION; SEQUENCE; INVITRO AB INTERLEUKIN-1-beta (IL-1-beta) IS THE PREDOMINANT FORM OF IL-1 produced by macrophages. IL-1-beta possesses numerous and diverse biological activities. Several of these activities, including fibroblast proliferation, potentiation of the immune response, and stimulation of bone resorption may be of relevance to the pathogenesis of periodontal disease. This study was designed to examine the presence of IL-1-beta in human periodontal tissue. An antiserum directed against the N-terminal segment (117-131) of human IL-1-beta was used to detect IL-1-beta using immunofluorescent staining techniques. IL-1-beta positive staining cells were observed in both normal and diseased tissue and were limited to the lamina propria. Brightly staining cells were increased by almost 3-fold in periodontally diseased tissue when compared to normal tissue. Low intensity staining cells were equally distributed in the normal and diseased specimens. We propose that IL-1-beta and IL-1-beta produced by cells in periodontal tissues may be related to the pathological processes associated with periodontal disease. C1 BIOTECH DIAGNOST,CAMBRIDGE,MA. UNIV MED & DENT NEW JERSEY,DEPT BIOL,NEWARK,NJ 07103. UNIV MED & DENT NEW JERSEY,DEPT DIAGNOST SCI,NEWARK,NJ 07103. UNIV MED & DENT NEW JERSEY,DEPT ANAT,NEWARK,NJ 07103. UNIV MED & DENT NEW JERSEY,DEPT PERIODONTOL,NEWARK,NJ 07103. FORSYTH DENT CTR,DEPT IMMUNOL,BOSTON,MA 02115. RP JANDINSKI, JJ (reprint author), UNIV MED & DENT NEW JERSEY,NEW JERSEY DENT SCH,DEPT ORAL PATHOL,110 BERGEN ST,NEWARK,NJ 07103, USA. FU NIDCR NIH HHS [DE-04881, DE-07378] NR 29 TC 89 Z9 90 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JAN PY 1991 VL 62 IS 1 BP 36 EP 43 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA ET463 UT WOS:A1991ET46300007 PM 2002430 ER PT J AU DANTZIG, JA HIBBERD, MG TRENTHAM, DR GOLDMAN, YE AF DANTZIG, JA HIBBERD, MG TRENTHAM, DR GOLDMAN, YE TI CROSS-BRIDGE KINETICS IN THE PRESENCE OF MGADP INVESTIGATED BY PHOTOLYSIS OF CAGED ATP IN RABBIT PSOAS MUSCLE-FIBERS SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Article ID SKELETAL-MUSCLE; ACTOMYOSIN SUBFRAGMENT-1; MUSCULAR-CONTRACTION; FORCE GENERATION; STRIATED-MUSCLE; SKINNED FIBERS; FROG-MUSCLE; ADP BINDING; RELAXATION; PHOSPHATE AB 1. The interaction between MgADP and rigor cross-bridges in glycerol-extracted single fibres from rabbit psoas muscle has been investigated using laser pulse photolysis of caged ATP (P3-1(2-nitrophenyl)ethyladenosine 5'-triphosphate) in the presence of MgADP and following small length changes applied to the rigor fibre. 2. Addition to 465-mu-M-MgADP to a rigor fibre caused rigor tension to decrease by 15.3 +/- 0.7% (S.E.M., n = 24 trials in thirteen fibres). The half-saturation value for this tension reduction was 18 +/- 4-mu-M (n = 23, thirteen fibres). 3. Relaxation from rigor by photolysis of caged ATP in the absence of CA2+ was markedly slowed by inclusion of 20-mu-M-2 mM-MgADP in the photolysis medium. 4. Four phases of tension relaxation occurred with MgADP in the medium: a(t), a quick partial relaxation (in pre-stretch fibres); b(t), a slowing of relaxation or a rise in tension for 50-100 ms; c(t), a sudden acceleration of relaxation; and d(t), a final, nearly exponential relaxation. 5. Experiments at varied MgATP and MgADP concentrations suggested that phase, a(t) is due to MgATP binding to nucleotide-free cross-bridges. 6. Phase b(t) was abbreviated by including 1-20 mM-orthophosphate (P(i)) in the photolysis medium, or by applying quick stretches before photolysis or during phase b(t). These results suggest that phases b(t) and c(t) are complex processes involving ADP dissociation, cross-bridge reattachment and co-operative detachment involving filament sliding and the Ca2+-regulatory system. 7. Stretching relaxed muscle fibres to 3.2-3.4-mu-m striation spacing followed by ATP removal and release of the rigor fibre until tension fell below the relaxed level allowed investigation of the strain dependence of relaxation in the regions of negative cross-bridge strain. In the presence of 50-mu-M-2 mM-MgADP and either 10 mM-P(i) or 20 mM-2,3-butanedione monoxime, relaxation following photolysis of caged ATP was 6- to 8-fold faster for negatively strained cross-bridges than for positively strained ones. This marked strain dependence of cross-bridge detachment is predicted from the model of A. F. Huxley (1957). 8. In the presence of Ca2+, activation of contraction following photolysis of caged ATP was slowed by inclusion of 20-500-mu-M-MgADP in the medium. An initial decrease in tension related to cross-bridge detachment by MgATP was markedly suppressed in the presence of MgADP. 9. Ten millimolar P(i) partly suppressed active tension generation in the presence of MgADP. The tension transients obtained when MgADP, Ca2+ and P(i) were included in the photolysis medium showed an unexpected initial tension rise following photolysis of caged ATP and then a decrease to the steady tension level. 10. Computer simulations of the cross-bridge reactions involving ADP release, MgATP binding, detachment, and reattachment into force-generating intermediates were fitted to the transients recorded following photolysis of caged ATP. In the absence of ADP the time course of the transients could be simulated using a simple model without strain-dependent rate constants and assuming that attached cross-bridge states in rapid equilibrium with detached states [GRAPHICS] and [GRAPHICS] exerted zero force. However, in the presence of MgADP the transients simulated with these assumptions showed a deeper tension dip following photolysis of caged ATP than the experimental records. 11. Two explanations of this discrepancy are considered. In the first hypothesis, rigor cross-bridges are assumed to be distributed over a wide range of forces, including negative forces, and ADP dissociates more rapidly from negatively strained cross-bridges than from positively strained ones. In the presence of MgADP, rapid detachment of the negatively strained cross-bridges limits the magnitude of tension dip following ATP release. 12. In the second explanation, in the presence of MgADP, attached cross-bridge states that are in rapid equilibrium with detached states [GRAPHICS] and [GRAPHICS] are considered to bear significant force. Force in these states limits the magnitude of the initial tension dip following release of ATP. Since [GRAPHICS] and [GRAPHICS] cannot bind MgADP, the assignment of tension to these states with MgADP present implies that in this model, interactions between cross-bridges or between individual heads of a myosin molecule occur in the presence of MgADP. Kinetic simulations on the basis of both models approximated the experimental records in the absence and presence of MgADP. However, the first model better accommodated data obtained in the presence of Ca2+, MgADP and P(i). C1 NATL INST MED RES,LONDON NW7 1AA,ENGLAND. MASSACHUSETTS GEN HOSP,BOSTON,MA 02146. RP DANTZIG, JA (reprint author), UNIV PENN,DEPT PHYSIOL,PHILADELPHIA,PA 19104, USA. FU NHLBI NIH HHS [HL15835]; NIADDK NIH HHS [AM00745] NR 58 TC 124 Z9 124 U1 1 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PD JAN PY 1991 VL 432 BP 639 EP 680 PG 42 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA ET456 UT WOS:A1991ET45600033 PM 1886072 ER PT J AU ROSENBAUM, JF BIEDERMAN, J HIRSHFELD, DR BOLDUC, EA FARAONE, SV KAGAN, J SNIDMAN, N REZNICK, JS AF ROSENBAUM, JF BIEDERMAN, J HIRSHFELD, DR BOLDUC, EA FARAONE, SV KAGAN, J SNIDMAN, N REZNICK, JS TI FURTHER EVIDENCE OF AN ASSOCIATION BETWEEN BEHAVIORAL-INHIBITION AND ANXIETY DISORDERS - RESULTS FROM A FAMILY STUDY OF CHILDREN FROM A NONCLINICAL SAMPLE SO JOURNAL OF PSYCHIATRIC RESEARCH LA English DT Article; Proceedings Paper CT 1989 ANNUAL MEETING OF THE NEW RESEARCH SECTION OF THE AMERICAN PSYCHIATRIC ASSOC CY MAY 06-11, 1989 CL SAN FRANCISCO, CA SP AMER PSYCHIAT ASSOC, NEW RES SECT ID ATTENTION DEFICIT DISORDER; PANIC DISORDER; MAJOR DEPRESSION; CO-MORBIDITY; GENERALIZED ANXIETY; SEPARATION ANXIETY; PSYCHIATRIC-DISORDERS; ANXIOUS CHILDREN; SOCIAL-BEHAVIOR; YOUNG-CHILDREN AB Behavioral inhibition to the unfamiliar, identifiable in early childhood and reflecting the tendency to exhibit withdrawal and excessive autonomic arousal to challenge or novelty, has been found to be prevalent in young offspring of parents with panic disorder and agoraphobia and associated with risk for anxiety disorders in these children. Using family study methodology, we now examine psychopathology in first degree relatives of children from a non-clinical longitudinal cohort identified at 21 months of age as inhibited (N = 22) or uninhibited (N = 19) and followed through the age of seven years for a study of preservation of temperamental characteristics in normal children. These assessments were compared with evaluations of the first degree relatives of 20 normal comparison children. Psychiatric assessments of parents (N = 110) and siblings (N = 72) were based on structured interviews conducted blindly to the temperamental classification of the index child. Parents of inhibited children, compared with parents of uninhibited and normal controls, had significantly higher risks for multiple (greater-than-or-equal-to 2) anxiety disorders, continuing anxiety disorders (both a childhood and adulthood anxiety disorder in the same parent), social phobia, and childhood avoidant and overanxious disorders. These findings provide additional support for the hypothesis linking behavioral inhibition with risk for anxiety disorder. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,PSYCHOSOMAT MED UNIT,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,CHILD PSYCHIAT SERV,BOSTON,MA 02114. HARVARD UNIV,DEPT PSYCHOL & SOCIAL RELAT,CAMBRIDGE,MA 02138. YALE UNIV,DEPT PSYCHOL,NEW HAVEN,CT 06520. HARVARD UNIV,SCH MED,BROCKTON W ROXBURY VET ADM MED CTR,PSYCHIAT EPIDEMIOL & GENET SECT,BOSTON,MA 02115. MASSACHUSETTS MENTAL HLTH CTR,DEPT PSYCHIAT,BOSTON,MA 02115. BOSTON UNIV,DOCTORAL PROGRAM CLIN PSYCHOL,BOSTON,MA 02215. RP ROSENBAUM, JF (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,CLIN PSYCHOPHARMACOL UNIT,WACC815,BOSTON,MA 02114, USA. NR 93 TC 140 Z9 142 U1 6 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0022-3956 J9 J PSYCHIAT RES JI J. Psychiatr. Res. PY 1991 VL 25 IS 1-2 BP 49 EP 65 DI 10.1016/0022-3956(91)90015-3 PG 17 WC Psychiatry SC Psychiatry GA GJ688 UT WOS:A1991GJ68800005 PM 2027095 ER PT J AU OZTURK, M AF OZTURK, M TI HUMAN CHORIONIC-GONADOTROPIN, ITS FREE SUBUNITS AND GESTATIONAL TROPHOBLASTIC DISEASE SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article ID HUMAN GLYCOPROTEIN HORMONES; FREE BETA-SUBUNIT; MONOCLONAL-ANTIBODIES; HYDATIDIFORM MOLE; IMMUNORADIOMETRIC ASSAYS; LUTEINIZING-HORMONE; NATURAL-HISTORY; ALPHA-SUBUNITS; HUMAN-PLACENTA; HCG AB Monoclonal antibody-based immunoassays can detect specifically intact human chorionic gonadotropin (hCG), the free alpha-subunit and the free beta-subunit. The differential production of hCG and its free subunits is important in gestational trophoblastic disease. Using well-defined epitope-specific monoclonal antibodies in an immunoradiometric assay format, specific and sensitive assays have been developed. Serum levels of free beta-hCG were abnormally high in patients with gestational trophoblastic disease. In contrast, free alpha-hCG levels in serum were not increased. C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RP OZTURK, M (reprint author), MASSACHUSETTS GEN HOSP,CTR CANC,MOLEC HEPATOL LAB,149 13TH ST,BOSTON,MA 02129, USA. RI ozturk, mehmet/G-3330-2014 FU NCI NIH HHS [CA-49832] NR 45 TC 13 Z9 13 U1 0 U2 2 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD JAN PY 1991 VL 36 IS 1 BP 21 EP 26 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA EU472 UT WOS:A1991EU47200006 PM 1706779 ER PT J AU OCONOR, LM WOODY, G YEH, HS MANNY, I DHOPESH, V AF OCONOR, LM WOODY, G YEH, HS MANNY, I DHOPESH, V TI METHADONE AND EDEMA SO JOURNAL OF SUBSTANCE ABUSE TREATMENT LA English DT Article DE METHADONE; EDEMA ID MAINTENANCE TREATMENT RP OCONOR, LM (reprint author), UNIV PENN,VET AFFAIRS MED CTR,DEPT PSYCHIAT,38TH & WOODLAND,PHILADELPHIA,PA 19104, USA. FU NIDA NIH HHS [DA0518603] NR 10 TC 8 Z9 8 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0740-5472 J9 J SUBST ABUSE TREAT JI J. Subst. Abus. Treat. PY 1991 VL 8 IS 3 BP 153 EP 155 DI 10.1016/0740-5472(91)90006-V PG 3 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA GJ353 UT WOS:A1991GJ35300006 PM 1960766 ER PT J AU ROSENBAUM, MS WILBER, DJ FINKELSTEIN, D RUSKIN, JN GARAN, H AF ROSENBAUM, MS WILBER, DJ FINKELSTEIN, D RUSKIN, JN GARAN, H TI IMMEDIATE REPRODUCIBILITY OF ELECTRICALLY INDUCED SUSTAINED MONOMORPHIC VENTRICULAR-TACHYCARDIA BEFORE AND DURING ANTIARRHYTHMIC THERAPY SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID ARRHYTHMIA INDUCTION; TACHYARRHYTHMIAS; STIMULATION; SELECTION; PREDICTION AB The immediate reproducibility of sustained ventricular tachycardia induction was evaluated prospectively during 106 studies performed in 53 patients with clinical sustained monomorphic ventricular tachycardia. Programmed electrical stimulation was performed twice, using the same protocol during 53 drug-free studies and 53 subsequent studies on antiarrhythmic therapy. Sustained monomorphic ventricular tachycardia was reproduced in 104 (98%) of the 106 studies. There was no significant difference in the incidence of reproducible tachycardia in the drug-free state compared with that observed during treatment with different classes of antiarrhythmic drugs. An increase in the number of extrastimuli was required to reinitiate the tachycardia in 9 (11%) of 83 studies in which single or double extrastimuli were initially required to induce the tachycardia. In 39 (37%) of 104 studies with reproducible tachycardia induction, the two tachycardias significantly differed in electrocardiographic (ECG) configuration and cycle length. These observations suggest that the overall reproducibility of ventricular tachycardia induction is sufficiently high to provide a reliable marker for evaluating the efficacy of therapeutic interventions. However, specific tachycardia characteristics such as cycle length and ECG configuration are more variable even within the same study and may be less useful in assessing the effects of subsequent interventions. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,CARDIAC UNIT,FRUIT ST,BOSTON,MA 02114. LOYOLA UNIV,MED CTR,CARDIOL SECT,MAYWOOD,IL 60153. NR 16 TC 23 Z9 24 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD JAN PY 1991 VL 17 IS 1 BP 133 EP 138 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EU231 UT WOS:A1991EU23100020 PM 1987216 ER PT J AU SKLAR, RM BROWN, RH AF SKLAR, RM BROWN, RH TI METHYLPREDNISOLONE INCREASES DYSTROPHIN LEVELS BY INHIBITING MYOTUBE DEATH DURING MYOGENESIS OF NORMAL HUMAN MUSCLE INVITRO SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article DE DYSTROPHIN; GLUCOCORTICOIDS; MYOTUBE DEATH; HUMAN MUSCLE CULTURE ID PROGRAMMED CELL-DEATH; HUMAN SKELETAL-MUSCLE; SERUM-FREE MEDIUM; CARNITINE DEFICIENCY; MUSCULAR-DYSTROPHY; SATELLITE CELLS; GROWTH; DIFFERENTIATION; CULTURE; GLUCOCORTICOIDS AB The glucocorticoid methylprednisolone (Mepd) increased dystrophin and myosin heavy chain levels in differentiated cultures of cloned human myoblasts. Mepd increased the number of myotubes per area by preventing myotube death and detachment during myogenesis in vitro. Myotube death was the result of an endogenous process initiated early during myoblast fusion. It occurred between days 4 and 5 of differentiation (3 days after its initiation) and was inhibited by cycloheximide, indicating that a programmed death mechanism may be involved. Inhibition of myotube death accounted for the increased levels of muscle-specific proteins; the amount of dystrophin per myonucleus was the same with or without Mepd treatment. These effects of glucocorticoids on primary muscle cultures may bear on the recent observation that prednisone transiently enhances muscle function in Duchenne muscular dystrophy. RP SKLAR, RM (reprint author), MASSACHUSETTS GEN HOSP,CECIL B DAY NEUROMUSCULAR RES LABS,149 13TH ST,NAVY YARD,BOSTON,MA 02129, USA. FU NINDS NIH HHS [R01 NS 00787-05] NR 37 TC 42 Z9 45 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD JAN PY 1991 VL 101 IS 1 BP 73 EP 81 DI 10.1016/0022-510X(91)90019-4 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA FA240 UT WOS:A1991FA24000008 PM 2027030 ER PT J AU KACHEL, TA VIJAN, SR DRETLER, SP AF KACHEL, TA VIJAN, SR DRETLER, SP TI ENDOUROLOGICAL EXPERIENCE WITH CYSTINE CALCULI AND A TREATMENT ALGORITHM SO JOURNAL OF UROLOGY LA English DT Article DE CYSTINE; KIDNEY CALCULI; URETERAL CALCULI ID SHOCK-WAVE LITHOTRIPSY; DISSOLUTION; TROMETHAMINE; IRRIGATION AB Between May 1984 and January 1988, 18 patients (31 pyeloureteral units) with documented symptomatic cystine stones were treated. Stone size ranged from 5 to 56 mm. in largest diameter, with an average of 21 mm. All pyeloureteral units were treated initially by endourological methods, including ureteroscopy in 10, percutaneous ultrasonic lithotripsy in 9, extracorporeal shock wave lithotripsy (ESWL*) in 10 and chemolysis in 2. Of the patients 10 required a combination of these technologies and 2 required an open operation. Of the 31 units 23 were free of stones when the patient was discharged from the hospital. Of 8 patients with retained stones only 3 had fragments greater than 3 mm. in diameter. Based on this experience an algorithm was developed for the urological management of cystine stones. Ureteral calculi may be removed by ureteroscopic techniques or manipulated into the renal pelvis and managed as renal stones. Cystine renal calculi of less than 1.5 cm. may be treated with ESWL monotherapy. Stones of 1.5 to 3 cm. may be treated with ESWL and dissolution, or percutaneous ultrasonic lithotripsy plus dissolution. Staghorn calculi may be treated by percutaneous ultrasonic lithotripsy plus ESWL and/or dissolution for retained fragments. C1 HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA 02115. RP KACHEL, TA (reprint author), MASSACHUSETTS GEN HOSP,UROL SERV,BOSTON,MA 02114, USA. NR 14 TC 47 Z9 47 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JAN PY 1991 VL 145 IS 1 BP 25 EP 28 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA EQ376 UT WOS:A1991EQ37600007 PM 1984093 ER PT J AU YEAGER, RA AF YEAGER, RA TI COMPARISON OF EJECTION FRACTION AND GOLDMAN RISK FACTOR-ANALYSIS TO DIPYRIDAMOLE-THALLIUM-201 STUDIES IN THE EVALUATION OF CARDIAC MORBIDITY AFTER AORTIC-ANEURYSM SURGERY SO JOURNAL OF VASCULAR SURGERY LA English DT Letter ID THALLIUM C1 PORTLAND VET AFFAIRS MED CTR,PORTLAND,OR 97207. RP YEAGER, RA (reprint author), OREGON HLTH SCI UNIV,DEPT SURG,DIV VASC SURG,PORTLAND,OR 97201, USA. NR 6 TC 4 Z9 4 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JAN PY 1991 VL 13 IS 1 BP 173 EP 173 PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA EV211 UT WOS:A1991EV21100020 PM 1987389 ER PT J AU HOM, RC FINBERG, RW MULLANEY, S RUPRECHT, RM AF HOM, RC FINBERG, RW MULLANEY, S RUPRECHT, RM TI PROTECTIVE CELLULAR RETROVIRAL IMMUNITY REQUIRES BOTH CD4+ AND CD8+ IMMUNE T-CELLS SO JOURNAL OF VIROLOGY LA English DT Article ID HERPES-SIMPLEX VIRUS; TOXIC LYMPHOCYTES-T; SYNGENEIC MURINE LEUKEMIA; ADOPTIVE IMMUNOTHERAPY; TYPE-1 INFECTION; INDUCED TUMORS; FRIEND-VIRUS; INVIVO; CLONES; INTERLEUKIN-2 C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,INFECT DIS LAB,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CANC PHARMACOL,BOSTON,MA 02115. RI Finberg, Robert/E-3323-2010 NR 31 TC 49 Z9 49 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 1991 VL 65 IS 1 BP 220 EP 224 PG 5 WC Virology SC Virology GA EM926 UT WOS:A1991EM92600027 PM 1898666 ER PT J AU KOWALSKI, M BERGERON, L DORFMAN, T HASELTINE, W SODROSKI, J AF KOWALSKI, M BERGERON, L DORFMAN, T HASELTINE, W SODROSKI, J TI ATTENUATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 CYTOPATHIC EFFECT BY A MUTATION AFFECTING THE TRANSMEMBRANE ENVELOPE GLYCOPROTEIN SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN PERIPHERAL-BLOOD; MONOCYTOID CELL-LINE; HTLV-III; T-CELL; AIDS PATIENTS; HUMAN RETROVIRUS; MESSENGER-RNA; PROTEIN; HIV-1; CD4 C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PATHOL,DIV HUMAN RETROVIROL,BOSTON,MA 02115. HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115. FU NIAID NIH HHS [AI24755, AI24845] NR 54 TC 123 Z9 123 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 1991 VL 65 IS 1 BP 281 EP 291 PG 11 WC Virology SC Virology GA EM926 UT WOS:A1991EM92600034 PM 1702159 ER PT J AU SHEPARD, AA DELUCA, NA AF SHEPARD, AA DELUCA, NA TI ACTIVITIES OF HETERODIMERS COMPOSED OF DNA-BINDING-DEFICIENT AND TRANSACTIVATION-DEFICIENT SUBUNITS OF THE HERPES-SIMPLEX VIRUS REGULATORY PROTEIN ICP4 SO JOURNAL OF VIROLOGY LA English DT Article ID TEMPERATURE-SENSITIVE MUTANTS; MACROMOLECULAR-SYNTHESIS; TRANSCRIPTIONAL ACTIVATOR; VIRAL POLYPEPTIDES; GENE-EXPRESSION; RNA SYNTHESIS; TYPE-1; HSV-1; CELLS; ASSOCIATION C1 HARVARD UNIV,SCH MED,COMM VIROL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. FU NIAID NIH HHS [AI27431] NR 47 TC 39 Z9 39 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 1991 VL 65 IS 1 BP 299 EP 307 PG 9 WC Virology SC Virology GA EM926 UT WOS:A1991EM92600036 PM 1845890 ER PT J AU FREUND, R GARCEA, RL SAHLI, R BENJAMIN, TL AF FREUND, R GARCEA, RL SAHLI, R BENJAMIN, TL TI A SINGLE-AMINO-ACID SUBSTITUTION IN POLYOMAVIRUS VP1 CORRELATES WITH PLAQUE SIZE AND HEMAGGLUTINATION BEHAVIOR SO JOURNAL OF VIROLOGY LA English DT Article ID SIALYLOLIGOSACCHARIDE RECEPTORS; INFLUENZA HEMAGGLUTININ; NONCODING SEQUENCES; TUMOR-INDUCTION; DNA-SEQUENCE; VIRUS; MICE; VARIANTS; PROFILES; PROTEIN C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,BOSTON,MA 02115. CHU VAUDOIS,INST MICROBIOL,CH-1011 LAUSANNE,SWITZERLAND. FU NCI NIH HHS [CA37667, R35-CA44343] NR 43 TC 85 Z9 87 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 1991 VL 65 IS 1 BP 350 EP 355 PG 6 WC Virology SC Virology GA EM926 UT WOS:A1991EM92600043 PM 1845896 ER PT J AU POZNANSKY, M LEVER, A BERGERON, L HASELTINE, W SODROSKI, J AF POZNANSKY, M LEVER, A BERGERON, L HASELTINE, W SODROSKI, J TI GENE-TRANSFER INTO HUMAN-LYMPHOCYTES BY A DEFECTIVE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VECTOR SO JOURNAL OF VIROLOGY LA English DT Note ID AIDS VIRUS; RETROVIRUS; REPLICATION; CELLS; CONSTRUCTION; SEQUENCES; CLONES; DNA; HIV; RNA C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PATHOL,DIV HUMAN RETROVIROL,BOSTON,MA 02115. HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115. ST GEORGE HOSP,SCH MED,DEPT CELLULAR & MOLEC SCI,DIV COMMUNICABLE DIS,LONDON SW17 0RE,ENGLAND. FU NIAID NIH HHS [AI27702] NR 28 TC 132 Z9 134 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 1991 VL 65 IS 1 BP 532 EP 536 PG 5 WC Virology SC Virology GA EM926 UT WOS:A1991EM92600071 PM 1985215 ER PT J AU BELL, DA AF BELL, DA TI THE PROGNOSTIC VALUE OF MITOTIC RATE AND THE VOLUME PERCENTAGE OF EPITHELIUM IN SEROUS BORDERLINE TUMORS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,CAMBRIDGE,MA 02138. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A54 EP A54 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600330 ER PT J AU CAJIGAS, HE SZYFELBEIN, WM AF CAJIGAS, HE SZYFELBEIN, WM TI CYTOMORPHOLOGY OF UNUSUAL SPINDLE CELL LESIONS - DIFFERENTIAL DIAGNOSIS-AND-DIAGNOSTIC PITFALLS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A23 EP A23 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600142 ER PT J AU CAJLGAS, HE LIMTAN, SK SCULLY, RE AF CAJLGAS, HE LIMTAN, SK SCULLY, RE TI UNUSUAL HISTOLOGIC-CHANGES IN OVARIAN SEROUS BORDERLINE TUMORS DURING PREGNANCY SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A55 EP A55 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600335 ER PT J AU DELAMONTE, SM AF DELAMONTE, SM TI GLIAL-CELL EXPRESSION OF GAP-43 IN BRAIN AND ABERRANTLY INCREASED LEVELS IN ALZHEIMERS-DISEASE WHITE MATTER SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,BOSTON,MA 02114. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A101 EP A101 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600609 ER PT J AU EICHHORN, JH SCULLY, RE AF EICHHORN, JH SCULLY, RE TI OVARIAN MYXOMA - A CLINICOPATHOLOGICAL AND IMMUNOHISTOLOGIC STUDY OF 5 CASES AND A REVIEW OF THE LITERATURE SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A56 EP A56 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600340 ER PT J AU FERRY, JA PETTIT, CK ROSENBERG, AE HARRIS, NL AF FERRY, JA PETTIT, CK ROSENBERG, AE HARRIS, NL TI FUNGI IN MEGAKARYOCYTES - AN UNUSUAL MANIFESTATION OF FUNGAL INFECTION OF THE BONE-MARROW SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A87 EP A87 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600528 ER PT J AU FERRY, JA ZUKERBERG, LR HARRIS, NL AF FERRY, JA ZUKERBERG, LR HARRIS, NL TI FLORID PROGRESSIVE TRANSFORMATION OF GERMINAL-CENTERS IN YOUNG MEN, WITHOUT PROGRESSION TO NODULAR LYMPHOCYTE PREDOMINANCE HODGKINS-DISEASE (NLPHD) SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A72 EP A72 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600436 ER PT J AU FERRY, JA ZUKERBERG, LR SKLAR, J HARRIS, NL AF FERRY, JA ZUKERBERG, LR SKLAR, J HARRIS, NL TI NASAL LYMPHOMA - A CLINICOPATHOLOGICAL STUDY WITH IMMUNOPHENOTYPIC AND GENOTYPIC ANALYSIS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. BRIGHAM & WOMENS HOSP,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A72 EP A72 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600435 ER PT J AU GRAEMECOOK, F BHAN, A HARRIS, NL AF GRAEMECOOK, F BHAN, A HARRIS, NL TI IMMUNOHISTOCHEMICAL CHARACTERIZATION OF INTRAEPITHELIAL AND SUBMUCOSAL LYMPHOID-CELLS OF UPPER AIRWAY MUCOSA SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A72 EP A72 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600439 ER PT J AU HAGAN, C ZUKERBERG, LR BHAN, AK DICKERSIN, GR AF HAGAN, C ZUKERBERG, LR BHAN, AK DICKERSIN, GR TI EPITHELIOID SMOOTH-MUSCLE TUMORS - AN IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL PROFILE SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A5 EP A5 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600035 ER PT J AU LEWANDROWSKI, K SCHMIDT, J WARSHAW, A RATTNER, D COMPTON, C AF LEWANDROWSKI, K SCHMIDT, J WARSHAW, A RATTNER, D COMPTON, C TI HISTOPATHOLOGY OF A COMBINED CERULEIN (CAE) GLYCODEOXYCHOLIC ACID (GDOC) MODEL OF ACUTE-PANCREATITIS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A93 EP A93 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600562 ER PT J AU MATSUBARA, O YOSHIMURA, N NUMANO, F KASUGA, T MARK, EJ AF MATSUBARA, O YOSHIMURA, N NUMANO, F KASUGA, T MARK, EJ TI PATHOLOGICAL FEATURES OF PULMONARY-ARTERY IN TAKAYASUS-ARTERITIS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 TOKYO MED & DENT UNIV,TOKYO 113,JAPAN. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A117 EP A117 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600708 ER PT J AU SALE, GE ANDERSON, P MYERSON, D AF SALE, GE ANDERSON, P MYERSON, D TI DIRECT EVIDENCE OF CYTOTOXIC T-CELL DESTRUCTION OF EPIDERMAL-CELLS IN HUMAN GRAFT-VERSUS-HOST DISEASE - IMMUNOHISTOLOGY WITH MONOCLONAL-ANTIBODY TIA-1 SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 UNIV WASHINGTON,FHCRC,SEATTLE,WA 98195. HARVARD UNIV,CAMBRIDGE,MA 02138. DANA FARBER CANC CTR,BOSTON,MA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A124 EP A124 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600748 ER PT J AU SOUTHERN, JF NARULA, J YASUDA, T FALLON, JT PALACIOS, IF DEC, GW NEWELL, JB STRAUSS, HW KHAW, BA HABER, E AF SOUTHERN, JF NARULA, J YASUDA, T FALLON, JT PALACIOS, IF DEC, GW NEWELL, JB STRAUSS, HW KHAW, BA HABER, E TI MYOFIBRILLARLYSIS AND UPTAKE OF IN-111 ANTIMYOSIN ANTIBODY IN MYOCARDIUM IDENTIFY A REVERSIBLE COMPONENT OF DILATED CARDIOMYOPATHY SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A21 EP A21 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600133 ER PT J AU SOUTHERN, JF NARULA, J CHOPRA, P TALWAR, KK VASAN, RS REDDY, KS TANDON, R BHATIA, ML AF SOUTHERN, JF NARULA, J CHOPRA, P TALWAR, KK VASAN, RS REDDY, KS TANDON, R BHATIA, ML TI ENDOMYOCARDIAL BIOPSY IN ACTIVE RHEUMATIC CARDITIS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A21 EP A21 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600134 ER PT J AU ZUKERBERG, L FERRY, J HARRIS, N AF ZUKERBERG, L FERRY, J HARRIS, N TI EXTRAMEDULLARY BLASTIC TUMORS - IMMUNOPHENOTYPIC PROFILE, ANTIGEN PROGRESSION AND COST-EFFECTIVE DIAGNOSTIC PANELS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A86 EP A86 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600521 ER PT J AU ZUKERBERG, L FERRY, J HARRIS, N AF ZUKERBERG, L FERRY, J HARRIS, N TI UNUSUAL VARIANT OF GERMINAL CENTER LYMPHOMA RESEMBLING REACTIVE HYPERPLASIA OR T-CELL LYMPHOMA SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A86 EP A86 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600520 ER PT J AU ZUKERBERG, L YOUNG, R SCULLY, R AF ZUKERBERG, L YOUNG, R SCULLY, R TI SCLEROSING SERTOLI-CELL TUMOR OF THE TESTIS SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A53 EP A53 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600326 ER PT J AU ZUKERBERG, LR MEDEIROS, LJ FERRY, JA HARRIS, NL AF ZUKERBERG, LR MEDEIROS, LJ FERRY, JA HARRIS, NL TI DIFFUSE LOW-GRADE B-CELL LYMPHOMAS - IDENTIFICATION OF 4 MAJOR IMMUNOPHENOTYPIC SUBTYPES SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A86 EP A86 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600522 ER PT J AU METSON, R REBEIZ, E WEST, C THORNTON, A AF METSON, R REBEIZ, E WEST, C THORNTON, A TI MAGNETIC STIMULATION OF THE FACIAL-NERVE SO LARYNGOSCOPE LA English DT Article ID HUMAN-BRAIN AB Intracranial activation of the facial nerve is now possible with the noninvasive techniques of magnetic stimulation. Brief magnetic pulses generated by a coil overlying the parietal scalp elicit compound muscle action potentials of similar shape and amplitude and greater latency than those produced by electroneurography. Mapping studies demonstrate the compound muscle action potentials to be of constant latency and varying amplitude with changing coil location. Maximum compound muscle action potential amplitudes are obtained with the coil center located in a rectangular area superior and posterior to the ear canal. A comparison of large and small diameter coils showed them to be equally effective for painless facial nerve stimulation; however, the smaller coil allowed for a more localized field of activation. Magnetic stimulation has the potential to provide cross-the-lesion testing of facial nerve function. C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,DEPT OTOLARYNGOL,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,DEPT AUDIOL,BOSTON,MA 02114. NR 13 TC 14 Z9 14 U1 0 U2 0 PU LARYNGOSCOPE CO PI ST LOUIS PA 10 S BROADWAY 14TH FLOOR, ST LOUIS, MO 63102-1741 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD JAN PY 1991 VL 101 IS 1 BP 25 EP 30 PN 1 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA EP945 UT WOS:A1991EP94500005 PM 1984547 ER PT J AU YASHIMA, Y MCAULIFFE, DJ JACQUES, SL FLOTTE, TJ AF YASHIMA, Y MCAULIFFE, DJ JACQUES, SL FLOTTE, TJ TI LASER-INDUCED PHOTOACOUSTIC INJURY OF SKIN - EFFECT OF INERTIAL CONFINEMENT SO LASERS IN SURGERY AND MEDICINE LA English DT Article DE EXCIMER; FIBROBLAST; SURFACE MODIFICATION; ULTRASTRUCTURE ID EXCIMER LASER; ABLATION; CORNEA; POLYMERS; NM; SURFACES; DAMAGE AB Argon-fluoride (ArF) excimer laser-induced acoustic injury was confirmed by ablating the stratum corneum (s.c.) inertially confined by water in vivo. Hairless rats were irradiated through a quartz chamber with flowing distilled water or air and a 2.5 mm aperture. The laser was adjusted to deliver 150 mJ/cm2 at the skin surface for both conditions. Partial and complete ablation of the s.c. was achieved with 12 and 24 pulses, respectively. Immediate damage was assessed by the transmission electron microscopy. Partial ablation of the s.c. through air produced no damage, whereas partial ablation through water damaged skin to a mean depth of 114.5 +/- 8.8-mu-m (+/-SD). Full thickness ablation of the s.c. through air and water produced damage zones measuring 192.2 +/- 16.2 and 293.0 +/- 71.6-mu-m, respectively (P < 0.05). The increased depth of damage in the presence of inertial confinement provided by the layer of water strongly supports a photoacoustic mechanism of damage. The damage induced by partial ablation of the s.c. provides evidence that photochemical injury is not a significant factor in the damage at a depth because the retained s.c. acts as a partial barrier to diffusion of photochemical products. Combined with our previous studies, these experiments demonstrate that pressure transients are responsible for the deep damage seen with 193 nm ablation and that photoacoustic effects must be considered when using short-pulse, high-peak power lasers. C1 HARVARD UNIV, MASSACHUSETTS GEN HOSP,SCH MED, WELLMAN LABS PHOTOMED,DEPT DERMATOL,WELLMAN 2, BOSTON, MA 02114 USA. HARVARD UNIV, MASSACHUSETTS GEN HOSP,SCH MED, WELLMAN LABS PHOTOMED,DEPT PATHOL, BOSTON, MA 02114 USA. UNIV TEXAS, MD ANDERSON CANC CTR, LASER BIOL RES LAB, HOUSTON, TX 77030 USA. NR 20 TC 37 Z9 37 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0196-8092 EI 1096-9101 J9 LASER SURG MED JI Lasers Surg. Med. PY 1991 VL 11 IS 1 BP 62 EP 68 DI 10.1002/lsm.1900110113 PG 7 WC Dermatology; Surgery SC Dermatology; Surgery GA ET621 UT WOS:A1991ET62100011 PM 1997782 ER PT J AU SCHOMACKER, KT DOMANKEVITZ, Y FLOTTE, TJ DEUTSCH, TF AF SCHOMACKER, KT DOMANKEVITZ, Y FLOTTE, TJ DEUTSCH, TF TI CO-MGF2 LASER ABLATION OF TISSUE - EFFECT OF WAVELENGTH ON ABLATION THRESHOLD AND THERMAL-DAMAGE SO LASERS IN SURGERY AND MEDICINE LA English DT Article DE PULSED INFRARED LASER ABLATION; TISSUE DAMAGE; CORNEA; BONE; AORTA; TISSUE DENATURATION; OPTICAL PROPERTIES OF WATER ID PULSED HOLMIUM LASER; YAG LASER; DURATION; LIVER; BONE AB The wavelength dependence of the ablation threshold of a variety of tissues has been studied by using a tunable pulsed Co:MgF2 laser to determine how closely it tracks the optical absorption length of water. The Co:MgF2 laser was tuned between 1.81 and 2.14-mu-m, a wavelength region in which the absorption length varies by a decade. For soft tissues the ablation threshold tracks the optical absorption length; for bone there is little wavelength dependence, consistent with the low water content of bone. Thermal damage vs. wavelength was also studied for cornea and bone. Thermal damage to cornea has a weak wavelength dependence, while that to bone shows little wavelength dependence. Framing-camera pictures of the ablation of both cornea and liver show explosive removal of material, but differ as to the nature of the explosion. C1 MASSACHUSETTS GEN HOSP,DEPT DERMATOL,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. NR 23 TC 41 Z9 43 U1 2 U2 4 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0196-8092 J9 LASER SURG MED JI Lasers Surg. Med. PY 1991 VL 11 IS 2 BP 141 EP 151 DI 10.1002/lsm.1900110208 PG 11 WC Dermatology; Surgery SC Dermatology; Surgery GA FE653 UT WOS:A1991FE65300007 PM 2034011 ER PT J AU VOGEL, A DLUGOS, C NUFFER, R BIRNGRUBER, R AF VOGEL, A DLUGOS, C NUFFER, R BIRNGRUBER, R TI OPTICAL-PROPERTIES OF HUMAN SCLERA, AND THEIR CONSEQUENCES FOR TRANSSCLERAL LASER APPLICATIONS SO LASERS IN SURGERY AND MEDICINE LA English DT Article DE CYCLODESTRUCTION; SCLERAL ABSORPTION; SCLERAL SCATTERING; SCLERAL TRANSMISSION; TRANSSCLERAL PHOTOCOAGULATION ID NEODYMIUM-YAG CYCLOPHOTOCOAGULATION; SEMICONDUCTOR DIODE-LASER; HUMAN AUTOPSY EYES; CONTACT LASER; CYCLOCOAGULATION; GLAUCOMA; RABBITS; INVITRO AB The spectral dependence of the optical properties of human sclera adjacent to the limbus was investigated and related to the potentials of transscleral photocoagulation. The total transmission, absorption, and reflection, as well as the angular distribution of the transmitted and reflected light were measured at five laser wavelengths (442 nm, 514 nm, 633 nm, 804 nm, and 1,064 nm), both for noncontact and contact applications. Absorption and scattering coefficients were determined using the Kubelka-Munk model for light propagation through a scattering tissue. The scleral transmission is only 6% at 442 nm but increases to 35% at 804 nm and to 53% at 1,064 nm. The absorption is high at short wavelengths with 40% at 442 nm but it is only 6% at 804 nm and 1,064 nm. The reflection is generally higher than 40% and shows little wavelength dependence. The transmitted light is scattered diffusely at short wavelengths, but at 804 nm and 1,064 nm it exhibits a fairly narrow angular distribution in forward direction. Fiber contact leads to an increase of transmission, with a factor of 3.5 at 442 nm, of 2.0 at 804 nm, and 1.5 at 1,064 nm. Our results indicate that the diode laser (804 nm) and the Nd:YAG laser (1,064 nm) with contact delivery are best suited for transscleral photocoagulation. C1 MASSACHUSETTS GEN HOSP,WELLMAN LAB PHOTOMED,BOSTON,MA 02114. RP VOGEL, A (reprint author), UNIV MUNICH,HOSP EYE,H WACKER LAB MED LASER APPLICAT,W-8000 MUNICH 2,GERMANY. RI Vogel, Alfred/D-9852-2011; Birngruber, Reginald/Q-2342-2016 NR 47 TC 115 Z9 117 U1 0 U2 8 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0196-8092 J9 LASER SURG MED JI Lasers Surg. Med. PY 1991 VL 11 IS 4 BP 331 EP 340 DI 10.1002/lsm.1900110404 PG 10 WC Dermatology; Surgery SC Dermatology; Surgery GA FZ427 UT WOS:A1991FZ42700003 PM 1895865 ER PT J AU BHATTA, KM RATTNER, DW HAW, TE NISHIOKA, NS AF BHATTA, KM RATTNER, DW HAW, TE NISHIOKA, NS TI NEW LASER DELIVERY DEVICE FOR LAPAROSCOPIC PROCEDURES SO LASERS IN SURGERY AND MEDICINE LA English DT Note DE LASER ASSISTED SCALPEL; LAPAROSCOPIC CHOLECYSTECTOMY; LAPAROSCOPIC LYMPH NODE DISSECTION; HEAT SEPARATION ID CHOLECYSTECTOMY AB A new device to facilitate laser delivery and improve mechanical advantage during surgical procedures is described. In the device, a quartz fiber is used to transmit laser energy to a forked metal tip. The utility of the device was assessed in five pigs. In three pigs a laparoscopic cholecystectomy was performed and in two pigs a laparoscopic lymph node dissection was performed. Advantages of the device included reduced smoke, clearer dissection planes, tactile feedback, and excellent mechanical advantage when used for blunt dissection. The device was qualitatively superior to both sculpted tip quartz fibers and electrocautery. RP BHATTA, KM (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT SURG,WELLMAN LABS PHOTOMED,50 BLOSSOM COURT,BOSTON,MA 02114, USA. NR 4 TC 2 Z9 2 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0196-8092 J9 LASER SURG MED JI Lasers Surg. Med. PY 1991 VL 11 IS 5 BP 481 EP 483 DI 10.1002/lsm.1900110515 PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA GJ895 UT WOS:A1991GJ89500014 PM 1840076 ER PT J AU BENNETT, JM ANDERSEN, JW CASSILETH, PA AF BENNETT, JM ANDERSEN, JW CASSILETH, PA TI LONG-TERM SURVIVAL IN ACUTE MYELOID-LEUKEMIA - THE-EASTERN-COOPERATIVE-ONCOLOGY-GROUP (ECOG) EXPERIENCE SO LEUKEMIA RESEARCH LA English DT Article DE PROMYELOCYTIC LEUKEMIA; CURABILITY OF LEUKEMIA ID ACUTE MYELOGENOUS LEUKEMIA; ACUTE NONLYMPHOCYTIC LEUKEMIA; MAINTENANCE CHEMOTHERAPY; REMISSION; CRITERIA; ADULTS; CURE AB A retrospective analysis of two ECOG adult AML trials conducted from 1976 to 1983 was carried out focusing on long term disease-free survival. This report summarizes the data on 545 patients with a minimum follow up of 7 1/2 years. The complete remission rate was 57% with an estimated cure rate of 12%. Of several prognostic variables examined only FAB type M3 (promyelocytic leukemia) was statistically significant (estimated cure rate of 33% vs 9% for other FAB subtypes). C1 UNIV ROCHESTER,MED CTR,ROCHESTER,NY 14642. HARVARD UNIV,SCH PUBL HLTH,DANA FARBER CANC INST,DIV BIOSTAT & EPIDEMIOL,BOSTON,MA 02115. UNIV PENN,CTR CANC,PHILADELPHIA,PA 19104. HOSP UNIV PENN,DEPT MED,PHILADELPHIA,PA 19104. RP BENNETT, JM (reprint author), UNIV ROCHESTER,CTR CANC,601 ELMWOOD AVE,ROCHESTER,NY 14642, USA. FU NCI NIH HHS [CA15488, CA11083, CA23318] NR 23 TC 35 Z9 38 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0145-2126 J9 LEUKEMIA RES JI Leuk. Res. PY 1991 VL 15 IS 4 BP 223 EP 227 DI 10.1016/0145-2126(91)90124-C PG 5 WC Oncology; Hematology SC Oncology; Hematology GA FJ132 UT WOS:A1991FJ13200008 PM 2030603 ER PT J AU KALIN, NH SHELTON, SE TURNER, JG AF KALIN, NH SHELTON, SE TURNER, JG TI EFFECTS OF ALPRAZOLAM ON FEAR-RELATED BEHAVIORAL, HORMONAL, AND CATECHOLAMINE RESPONSES IN INFANT RHESUS-MONKEYS SO LIFE SCIENCES LA English DT Article ID CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL ACTIVITY; BENZODIAZEPINE RECEPTORS; BRAIN CATECHOLAMINES; RAT-BRAIN; IMIPRAMINE; DIAZEPAM; DOPAMINE; PLASMA; CHLORDIAZEPOXIDE AB We tested the effects of various doses of the triazolobenzodiazepine alprazolam on behavioral, hormonal, and neurochemical responses of infant rhesus monkeys under three conditions of separation from their mothers: alone, in the presence of a human who stared at them, and in the presence of a human who avoided eye contact. Alprazolam affected stress-induced responses in all three of these classes. Unrelated to its effects on the stress response, alprazolam appears to reduce the function of brain dopamine systems. C1 WILLIAM S MIDDLETON MEM VET ADM MED CTR,MADISON,WI 53705. RP KALIN, NH (reprint author), UNIV WISCONSIN,SCH MED,DEPT PSYCHIAT,600 HIGHLAND AVE,MADISON,WI 53792, USA. FU NIMH NIH HHS [MH46729] NR 34 TC 18 Z9 18 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1991 VL 49 IS 26 BP 2031 EP 2044 DI 10.1016/0024-3205(91)90646-S PG 14 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA GQ672 UT WOS:A1991GQ67200011 PM 1660955 ER PT J AU JENKINS, BG AF JENKINS, BG TI DETECTION OF SITE-SPECIFIC BINDING AND CO-BINDING OF LIGANDS TO MACROMOLECULES USING F-19 NMR SO LIFE SCIENCES LA English DT Review ID NUCLEAR MAGNETIC-RESONANCE; HUMAN-SERUM ALBUMIN; IRON-MOLYBDENUM COFACTOR; TWO-DIMENSIONAL NMR; DIHYDROFOLATE-REDUCTASE; CHEMICAL-SHIFTS; COMPLEXES; SPECTROSCOPY; METABOLISM; PROTEIN AB Study of ligand-macromolecular interactions by F-19 nuclear magnetic resonance (NMR) spectroscopy affords many opportunities for obtaining molecular biochemical and pharmaceutical information. This is due to the absence of a background fluorine signal, as well as the relatively high sensitivity of F-19 NMR. Use of fluorine-labeled ligands enables one to probe not only binding and co-binding phenomena to macromolecules, but also can provide data on binding constants, stoichiometries, kinetics, and conformational properties of these complexes. Under conditions of slow exchange and macromolecule-induced chemical shifts, multiple F-19 NMR resonances can be observed for free and bound ligands. These shifted resonances are a direct correlate of the concentration of ligand bound in a specific state rather than the global concentrations of bound or free ligand which are usually determined using other techniques such as absorption spectroscopy or equilibrium dialysis. Examples of these interactions are demonstrated both from the literature and from interactions of 5-fluorotryptophan, 5-fluorosalicylic acid, flurbiprofen, and sulindac sulfide with human serum albumin. Other applications of F-19 NMR to study of these interactions in vivo, as well for receptor binding and metabolic tracing of fluorinated drugs and proteins are discussed. C1 HARVARD UNIV,SCH MED,BOSTON,MA 02129. RP JENKINS, BG (reprint author), MASSACHUSETTS GEN HOSP,NMR CTR,BOSTON,MA 02129, USA. NR 62 TC 19 Z9 19 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1991 VL 48 IS 13 BP 1227 EP 1240 DI 10.1016/0024-3205(91)90517-F PG 14 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA EZ251 UT WOS:A1991EZ25100001 PM 2002752 ER PT J AU ALSTON, TA AF ALSTON, TA TI INHIBITION OF VITAMIN B12-DEPENDENT MICROBIAL-GROWTH BY NITROUS-OXIDE SO LIFE SCIENCES LA English DT Article AB In methionine-free media, nitrous oxide inhibits the growth of an auxotrophic strain of Escherichia coli lacking a cobalamin-independent pathway for the de novo synthesis of methionine. Prototrophic E. coli is similarly inhibited by nitrous oxide if the cobalamin-independent pathway is selectively depressed by sulfanilamide. Nitrous oxide thus effectively inactivates cobalamin-dependent 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, EC 2.1.1.13) in intact bacteria. RP ALSTON, TA (reprint author), MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,CARDIAC ANESTHESIA GRP,BOSTON,MA 02114, USA. NR 18 TC 4 Z9 4 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1991 VL 48 IS 16 BP 1591 EP 1595 DI 10.1016/0024-3205(91)90284-I PG 5 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA FB842 UT WOS:A1991FB84200011 PM 2016991 ER PT J AU COHEN, MS WEISSKOFF, RM AF COHEN, MS WEISSKOFF, RM TI ULTRA-FAST IMAGING SO MAGNETIC RESONANCE IMAGING LA English DT Review DE NMR; MAGNETIC RESONANCE IMAGING (MRI); ECHO PLANAR IMAGING; INSTASCAN; FAST IMAGING AB The relatively long scan times with currently available technology restrict the range of MRI applications, increase the cost of scanning by limiting throughput, and lead to image artifacts from patients motion during scans. Ultrafast imaging, in several guises, is now poised for introduction into clinical practice. With the Instascan method, a descendant of the echo-planar technique, complete MR images may be obtained hundreds to thousands of times faster than in conventional approaches and now yield spatial resolution and contrast directly comparable to standard MRI. "Single-shot" imaging methods, such as Instascan, are utilized in the study of dynamic processes, in the direct evaluation of motion (as in diffusion sensitive imaging), and in dramatic new applications, including the interactive control of intraparenchymal laser surgery. Improvements to the small flip-angle method, FLASH, have also pushed scan times into the subsecond domain; this method may be implemented on presently available imaging equipment but yields contrast behavior different from the traditional spin-echo techniques and displays signal-to-noise ratios significantly lower than single-shot imaging. Ultimately, incorporating ultra-fast MR imaging techniques into the armamentarium of the radiologist will likely require changes to many aspects of the MRI practice, from expanded involvement with the scan process to management of the increased data load, and may lead to dramatic changes in the scope of the MRI practice. RP COHEN, MS (reprint author), MASSACHUSETTS GEN HOSP,CTR IMAGING,BLDG 149,13TH ST,BOSTON,MA 02129, USA. RI Cohen, Mark/C-6610-2011 OI Cohen, Mark/0000-0001-6731-4053 NR 0 TC 176 Z9 177 U1 2 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0730-725X J9 MAGN RESON IMAGING JI Magn. Reson. Imaging PY 1991 VL 9 IS 1 BP 1 EP 37 DI 10.1016/0730-725X(91)90094-3 PG 37 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EZ432 UT WOS:A1991EZ43200001 PM 2056846 ER PT J AU THOMPSON, RC LIU, P BRADY, TJ OKADA, RD JOHNSTON, DL AF THOMPSON, RC LIU, P BRADY, TJ OKADA, RD JOHNSTON, DL TI SERIAL MAGNETIC-RESONANCE-IMAGING IN PATIENTS FOLLOWING ACUTE MYOCARDIAL-INFARCTION SO MAGNETIC RESONANCE IMAGING LA English DT Article DE MAGNETIC RESONANCE IMAGING; ACUTE MYOCARDIAL INFARCTION AB The detection of serial changes in magnetic resonance (MR) signal intensity of the heart following acute myocardial infarction may provide a useful method of characterizing tissue healing. Fourteen patients with acute Q-wave infarction underwent T2-weighted, spin-echo cardiac imaging during hospitalization, followed by one or more additional MR studies (total 31) over a 6- to 27-wk period (mean: 3 mo). Visual assessment of the images demonstrated a gradual reduction in signal intensity and localization of the bright signal to the subendocardium of the infarction region over the three-mo study period. A quantitative measurement of signal intensity (infarction/normal myocardium) fell from 1.81 +/- 0.42 on the initial study to 1.34 +/- 0.37 (p < 0.05) at a mean of 14 wk. Two patients had an increase in signal intensity on the follow-up study and both patients had been readmitted with acute coronary syndromes. In summary, characterization of changes in signal intensity may provide a useful method of assessing myocardial healing following acute myocardial infarction. Further studies are indicated to determine the prognostic significance of these parameters. C1 MASSACHUSETTS GEN HOSP,DEPT MED,CARDIAC UNIT,BOSTON,MA 02114. NR 0 TC 15 Z9 15 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0730-725X J9 MAGN RESON IMAGING JI Magn. Reson. Imaging PY 1991 VL 9 IS 2 BP 155 EP 158 DI 10.1016/0730-725X(91)90004-6 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FD964 UT WOS:A1991FD96400004 PM 1824023 ER PT J AU ROZENMAN, Y ZOU, XM KANTOR, HL AF ROZENMAN, Y ZOU, XM KANTOR, HL TI MAGNETIC-RESONANCE-IMAGING WITH SUPERPARAMAGNETIC IRON-OXIDE PARTICLES FOR THE DETECTION OF MYOCARDIAL REPERFUSION SO MAGNETIC RESONANCE IMAGING LA English DT Article DE NUCLEAR MAGNETIC RESONANCE; IRON OXIDE; REPERFUSION; RAT; MYOCARDIAL ISCHEMIA; MAGNETIC RESONANCE IMAGING AB The effect of superparamagnetic iron oxide particles on magnetic resonance myocardial signal intensity was examined in order to define the ability of this agent to identify normal, ischemic, and reperfused myocardium. Data were obtained from 6 normal rats (group 1) and from 6 heterotopic isogenic rat heart transplants (group 2) at 4.7 T with a multislice spin-echo sequence. Images were acquired in (a) normal rats before and after the infusion of 36-mu-mol Fe/kg of AMI-25 (group 1) and (b) rat heart transplants during control, global myocardial ischemia (before and after the injection of 72-mu-mol Fe/kg of AMI-25), and following reperfusion (group 2). Myocardial signal intensity decreased by 36 +/- 4%, p < 0.001, following contrast infusion in normal hearts (group 1). The intensity remained constant in the rat heart transplants (group 2) during coronary occlusion, both before and after the infusion of AMI-25 and decreased by 61 +/- 7%, p < 0.001, upon reperfusion. The larger effect of AMI-25 in reperfused as compared to normal myocardium suggests the presence of ischemia-induced hyperemia. There was no significant difference (analysis of variance) among intensities from different myocardial regions in either group at any stage of the experiment. We conclude that the use of AMI-25 permits identification of normal, ischemic, and reperfused myocardium and may therefore be helpful for the early detection of reperfusion following thrombolytic therapy for acute myocardial infarction. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,CARDIAC UNIT,BOSTON,MA 02114. FU NCRR NIH HHS [RR-00995]; NHLBI NIH HHS [HL39810-02, HL34454-03] NR 0 TC 14 Z9 14 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0730-725X J9 MAGN RESON IMAGING JI Magn. Reson. Imaging PY 1991 VL 9 IS 6 BP 933 EP 939 DI 10.1016/0730-725X(91)90538-W PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GV753 UT WOS:A1991GV75300007 PM 1766318 ER PT J AU JENKINS, BG ARMSTRONG, E LAUFFER, RB AF JENKINS, BG ARMSTRONG, E LAUFFER, RB TI SITE-SPECIFIC WATER PROTON RELAXATION ENHANCEMENT OF IRON(III) CHELATES NONCOVALENTLY BOUND TO HUMAN SERUM-ALBUMIN SO MAGNETIC RESONANCE IN MEDICINE LA English DT Article; Proceedings Paper CT DISCUSSION MEETING ON NMR IMAGING AND SPECTROSCOPY : ADVANCED TOPICS IN IMPLEMENTATION CY JUN 07, 1990 CL CIBA FDN, LONDON, ENGLAND SP CIBA FDN HO CIBA FDN ID MAGNETIC-RELAXATION; TRANSLATIONAL DIFFUSION; PROTEIN HYDRATION; SOLVENT PROTONS; IRON-EHPG; BINDING; DISPERSION; DEPENDENCE; COMPLEXES; AGENTS C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP JENKINS, BG (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,NUCL MAGNET RESONANCE SECT,BOSTON,MA 02114, USA. FU NIGMS NIH HHS [GM-37777] NR 37 TC 32 Z9 32 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0740-3194 J9 MAGNET RESON MED JI Magn.Reson.Med. PD JAN PY 1991 VL 17 IS 1 BP 164 EP 178 DI 10.1002/mrm.1910170120 PG 15 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA ET386 UT WOS:A1991ET38600019 PM 1648652 ER PT J AU JONES, B FREEMAN, AI SHUSTER, JJ JACQUILLAT, C WEIL, M POCHEDLY, C SINKS, L CHEVALIER, L MAURER, HM KOCH, K FALKSON, G PATTERSON, R SELIGMAN, B SARTORIUS, J KUNG, F HAURANI, F STUART, M BURGERT, EO RUYMANN, F SAWITSKY, A FORMAN, E PLUESS, H TRUMAN, J HAKAMI, N GLIDEWELL, O GLICKSMAN, AS HOLLAND, JF AF JONES, B FREEMAN, AI SHUSTER, JJ JACQUILLAT, C WEIL, M POCHEDLY, C SINKS, L CHEVALIER, L MAURER, HM KOCH, K FALKSON, G PATTERSON, R SELIGMAN, B SARTORIUS, J KUNG, F HAURANI, F STUART, M BURGERT, EO RUYMANN, F SAWITSKY, A FORMAN, E PLUESS, H TRUMAN, J HAKAMI, N GLIDEWELL, O GLICKSMAN, AS HOLLAND, JF TI LOWER INCIDENCE OF MENINGEAL LEUKEMIA WHEN PREDNISONE IS REPLACED BY DEXAMETHASONE IN THE TREATMENT OF ACUTE LYMPHOCYTIC-LEUKEMIA SO MEDICAL AND PEDIATRIC ONCOLOGY LA English DT Article DE CANCER AND LEUKEMIA GROUP-B; CNS LEUKEMIA; STEROID THERAPY ID CENTRAL-NERVOUS-SYSTEM; ACUTE LYMPHOBLASTIC LEUKEMIA; CRANIAL IRRADIATION; CHILDHOOD LEUKEMIA; INTENSIVE CHEMOTHERAPY; CHILDREN; METHOTREXATE; PROPHYLAXIS; PREVENTION; PROTOCOL AB In 1971, Cancer and Leukemia Group B (CALGB) mounted a study of acute lymphocytic leukemia (ALL) that compared the effects of the two steroid hormones dexamethasome and prednisone. Six-hundred-forty-six children and adolescents with ALL were randomized to receive either prednisone or dexamethasone as part of their remission induction therapy. The 493 evaluable patients who achieved complete remission received the same steroid as pulses throughout remission. Specific central nervous system (CNS) therapy was randomized to either six injections of intrathecal methotrexate (IT MTX) alone or to six injections of IT MTX with cranial radiation (2,400 cGy). Both cranial radiation and dexamethasone offered increased protection against CNS relapse as the first site of failure over IT MTX alone. There were 30 CNS relapses among 238 patients (12.6%) receiving cranial radiation plus IT MTX, whereas there were 70 CNS relapses among 225 (P < 0.001) (22.5%) in those who received IT MTX alone. Similarly, there were 33 CNS relapses among 231 (14.3%) children treated with dexamethasone, whereas there were 67 CNS relapses among 262 (25.6%) treated with prednisone (P = 0.017). Both steroids appeared equal in protecting the bone marrow. Recent national studies have shown significant improvements in preventing CNS relapse over the results in the present report. However, this finding warrants further investigation and, with further documentation, could lead to the substitution of prednisone by dexamethasone to aid further in preventing CNS relapse. This may be particularly important in patients at higher risk for CNS relapse. C1 NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. UNIV FLORIDA,DEPT STAT,GAINESVILLE,FL 32611. HOP ST LOUIS,INST RECH LEUCEMIES,F-75010 PARIS,FRANCE. MONTREAL CHILDRENS HOSP,MONTREAL H3H 1P3,QUEBEC,CANADA. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298. UNIV MIAMI,MED CTR,MIAMI,FL 33152. UNIV PRETORIA,PRETORIA,SOUTH AFRICA. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC 27103. UNIV BASEL,KINDERSPITAL,CH-4051 BASEL,SWITZERLAND. UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093. THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,PHILADELPHIA,PA 19107. SUNY UPSTATE MED CTR,SYRACUSE,NY 13210. MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. LONG ISL JEWISH MED CTR,NEW HYDE PK,NY 11042. BROWN UNIV,PROVIDENCE,RI 02912. RHODE ISL HOSP,PROVIDENCE,RI 02902. KINDERSPITAL,CH-8032 ZURICH,SWITZERLAND. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. UNIV MISSOURI,COLUMBIA,MO 65201. CUNY MT SINAI SCH MED,NEW YORK,NY 10029. MT SINAI HOSP,NEW YORK,NY. SUNY,JEWISH HOSP BROOKLYN,BROOKLYN,NY. NR 33 TC 102 Z9 105 U1 0 U2 3 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-1532 J9 MED PEDIATR ONCOL JI Med. Pediatr. Oncol. PY 1991 VL 19 IS 4 BP 269 EP 275 DI 10.1002/mpo.2950190411 PG 7 WC Oncology; Pediatrics SC Oncology; Pediatrics GA FT990 UT WOS:A1991FT99000010 PM 2056971 ER PT J AU DAWSON, NA COSTANZA, ME KORZUN, AH CLAMON, GH POLLAK, M VOGELZANG, NJ CAREY, RW NORTON, L AF DAWSON, NA COSTANZA, ME KORZUN, AH CLAMON, GH POLLAK, M VOGELZANG, NJ CAREY, RW NORTON, L TI TRIMETREXATE IN UNTREATED AND PREVIOUSLY TREATED PATIENTS WITH METASTATIC BREAST-CANCER - A CANCER AND LEUKEMIA GROUP-B STUDY SO MEDICAL AND PEDIATRIC ONCOLOGY LA English DT Article DE CARCINOMA; BREAST; TRIMETREXATE ID PHASE-I; CLINICAL-PHARMACOLOGY; SCHEDULE AB Twenty-two patients with previously untreated metastatic breast cancer and nineteen patients with refractory metastatic breast cancer were treated with trimetrexate (TMTX). Patients received TMTX 8 mg/m2/day if previously treated or 12 mg/m2/day if previously untreated, both given by intravenous bolus days 1-5, every 21 days. None of the patients previously treated for metastatic disease responded to TMTX. There was one partial responder among the 22 patients with previously untreated metastatic disease. The primary toxicity was hematologic and occurred more frequently in patients with a pleural effusion, low serum protein or albumin, or poor performance status. There were three toxic deaths. The study for previously untreated patients required cyclophosphamide, doxorubicin, and 5-fluorouracil (CAF) after 4 cycles of TMTX. This study design for previously untreated patients allows the Cancer and Leukemia Group B (CALGB) to prospectively evaluate the activity of new agents in "chemotherapy-sensitive" metastatic breast cancer. C1 UNIV MASSACHUSETTS,SCH MED,WORCESTER,MA 01605. HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115. UNIV IOWA,IOWA CITY,IA 52242. UNIV CHICAGO,CHICAGO,IL 60637. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. MCGILL CANC CTR,MONTREAL,QUEBEC,CANADA. RP DAWSON, NA (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. RI Pollak, Michael/G-9094-2011 OI Pollak, Michael/0000-0003-3047-0604 FU NCI NIH HHS [CA-31809, CA-41287, CA-47642] NR 16 TC 12 Z9 12 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-1532 J9 MED PEDIATR ONCOL JI Med. Pediatr. Oncol. PY 1991 VL 19 IS 4 BP 283 EP 288 DI 10.1002/mpo.2950190413 PG 6 WC Oncology; Pediatrics SC Oncology; Pediatrics GA FT990 UT WOS:A1991FT99000012 PM 1829134 ER PT J AU ARONOW, DB PAYNE, TH PINCETL, SP AF ARONOW, DB PAYNE, TH PINCETL, SP TI POSTDOCTORAL TRAINING IN MEDICAL INFORMATICS - A SURVEY OF NATIONAL-LIBRARY-OF-MEDICINE SUPPORTED FELLOWS SO MEDICAL DECISION MAKING LA English DT Article DE MEDICAL INFORMATICS; SCAMC; COMPUTERS; NATIONAL-LIBRARY-OF-MEDICINE AB The National Library of Medicine (NLM) funds training programs in medical informatics and plans to significantly increase the number of program sites in the future. The authors surveyed all NLM-funded trainees at the nine sites supported in the spring of 1988 to determine their backgrounds, current research interests, and career plans. Forty-three fellows were identified, of whom 39 returned a mailed questionnaire. All but four were physicians (89.7%), 82.1% had at least one year of postdoctoral clinical training, and 61.5% had completed a residency. Seventy-one percent of those completing residency had done so in internal medicine. The most common areas of current research were decision support/decision analysis, knowledge representation, and artificial intelligence. The overwhelming majority of the fellows planned to seek positions in a medical school on completion of their fellowships, and most preferred affiliation with a department of medical informatics or medicine. C1 MASSACHUSETTS GEN HOSP,COMP SCI LAB,BOSTON,MA 02114. RP ARONOW, DB (reprint author), HARVARD UNIV,COMMUNITY HLTH PLAN,1 FENWAY PLAZA,BOSTON,MA 02115, USA. NR 5 TC 6 Z9 6 U1 0 U2 1 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 0272-989X J9 MED DECIS MAKING JI Med. Decis. Mak. PD JAN-MAR PY 1991 VL 11 IS 1 BP 29 EP 32 DI 10.1177/0272989X9101100104 PG 4 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA ER812 UT WOS:A1991ER81200004 PM 2034071 ER PT J AU ASCH, DA PATTON, JP HERSHEY, JC AF ASCH, DA PATTON, JP HERSHEY, JC TI PROGNOSTIC INFORMATION VERSUS ACCURACY - ONCE MORE WITH MEANING - REPLY SO MEDICAL DECISION MAKING LA English DT Letter ID DECISION-MAKING C1 UNIV PENN,VET AFFAIRS MED CTR,PHILADELPHIA,PA 19104. HOSP UNIV PENN,GEN INTERNAL MED SECT,PHILADELPHIA,PA 19104. UNIV PENN,WHARTON SCH,PHILADELPHIA,PA 19104. UNIV PENN,LEONARD DAVIS INST HLTH ECON,PHILADELPHIA,PA 19104. NR 7 TC 9 Z9 9 U1 1 U2 1 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 0272-989X J9 MED DECIS MAKING JI Med. Decis. Mak. PD JAN-MAR PY 1991 VL 11 IS 1 BP 45 EP 47 DI 10.1177/0272989X9101100108 PG 3 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA ER812 UT WOS:A1991ER81200008 PM 1827859 ER PT J AU CHERRY, JM AF CHERRY, JM TI CODON USAGE TABLE FOR XENOPUS-LAEVIS SO METHODS IN CELL BIOLOGY LA English DT Review C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0091-679X J9 METHOD CELL BIOL JI Methods Cell Biol. PY 1991 VL 36 BP 675 EP 677 PG 3 WC Cell Biology SC Cell Biology GA MC414 UT WOS:A1991MC41400038 PM 1811159 ER PT J AU WORKMAN, JL TAYLOR, ICA KINGSTON, RE ROEDER, RG AF WORKMAN, JL TAYLOR, ICA KINGSTON, RE ROEDER, RG TI CONTROL OF CLASS-II GENE-TRANSCRIPTION DURING IN-VITRO NUCLEOSOME ASSEMBLY SO METHODS IN CELL BIOLOGY LA English DT Review ID RNA POLYMERASE-II; XENOPUS-LAEVIS OOCYTES; IMMEDIATE EARLY PROTEIN; TUMOR VIRUS PROMOTER; MAJOR LATE; GAL4 DERIVATIVES; PREINITIATION COMPLEXES; HYPERSENSITIVE SITES; PURIFIED COMPONENTS; HISTONE COMPLEXES C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. HARVARD UNIV,DEPT GENET,BOSTON,MA 02115. ROCKEFELLER UNIV,DEPT BIOCHEM & MOLEC BIOL,NEW YORK,NY 10021. FU NCI NIH HHS [CA 42567] NR 69 TC 53 Z9 53 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0091-679X J9 METHOD CELL BIOL JI Methods Cell Biol. PY 1991 VL 35 BP 419 EP 447 PG 29 WC Cell Biology SC Cell Biology GA MC413 UT WOS:A1991MC41300017 PM 1779863 ER PT J AU HOCKENSMITH, JW KUBASEK, WL VORACHEK, WR EVERTSZ, EM VONHIPPEL, PH AF HOCKENSMITH, JW KUBASEK, WL VORACHEK, WR EVERTSZ, EM VONHIPPEL, PH TI LASER CROSS-LINKING OF PROTEIN NUCLEIC-ACID COMPLEXES SO METHODS IN ENZYMOLOGY LA English DT Review ID COLI RNA-POLYMERASE; TERMINATION FACTOR-RHO; DNA-BINDING PROTEIN; ESCHERICHIA-COLI; PHOTOCHEMICAL ADDITION; ULTRAVIOLET-LIGHT; AMINO-ACIDS; DROSOPHILA-MELANOGASTER; UV-IRRADIATION; TRANSCRIPTION C1 UNIV VIRGINIA,SCH MED,DEPT BIOCHEM,CHARLOTTESVILLE,VA 22908. MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403. UNIV OREGON,DEPT CHEM,EUGENE,OR 97403. UNIV OREGON,DEPT BIOL,EUGENE,OR 97403. FU NIGMS NIH HHS [GM-29158, GM-15792, GM-07759] NR 58 TC 81 Z9 82 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0076-6879 J9 METHOD ENZYMOL JI Method Enzymol. PY 1991 VL 208 BP 211 EP 235 PG 25 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA MC428 UT WOS:A1991MC42800014 PM 1779835 ER PT J AU WAXMAN, DJ AF WAXMAN, DJ TI RAT HEPATIC P450IIA AND P450IIC SUBFAMILY EXPRESSION USING CATALYTIC, IMMUNOCHEMICAL, AND MOLECULAR PROBES SO METHODS IN ENZYMOLOGY LA English DT Review ID INDUCED STEROID 16-ALPHA-HYDROXYLASE; LIVER MICROSOMAL CYTOCHROME-P-450; PHENOL-CHLOROFORM EXTRACTION; P-450 ENZYME EXPRESSION; SINGLE-STEP METHOD; TESTOSTERONE 7-ALPHA-HYDROXYLASE; MONOCLONAL-ANTIBODIES; HORMONAL-REGULATION; RNA ISOLATION; PURIFICATION C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. RP WAXMAN, DJ (reprint author), HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115, USA. FU NIDDK NIH HHS [DK33765, R01 DK033765] NR 48 TC 95 Z9 95 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0076-6879 J9 METHOD ENZYMOL JI Method Enzymol. PY 1991 VL 206 BP 249 EP 267 PG 19 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA HG720 UT WOS:A1991HG72000024 PM 1784212 ER PT J AU KOCH, JA WAXMAN, DJ AF KOCH, JA WAXMAN, DJ TI P450 PHOSPHORYLATION IN ISOLATED HEPATOCYTES AND INVIVO SO METHODS IN ENZYMOLOGY LA English DT Review ID ISOLATED RAT HEPATOCYTES; PHENOBARBITAL-INDUCIBLE CYTOCHROME-P-450; METABOLIZING ENZYMES; CYTOCHROMES-P-450; INDUCTION; CULTURES; DEGRADATION; CLEAVAGE; HORMONE C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. RP KOCH, JA (reprint author), HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115, USA. FU NIDDK NIH HHS [DK-33765] NR 30 TC 11 Z9 11 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0076-6879 J9 METHOD ENZYMOL JI Method Enzymol. PY 1991 VL 206 BP 305 EP 315 PG 11 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA HG720 UT WOS:A1991HG72000029 PM 1664478 ER PT J AU WAXMAN, DJ AF WAXMAN, DJ TI P450-CATALYZED STEROID HYDROXYLATION - ASSAY AND PRODUCT IDENTIFICATION BY THIN-LAYER CHROMATOGRAPHY SO METHODS IN ENZYMOLOGY LA English DT Review ID MICROSOMAL ANDROSTENEDIONE 7-ALPHA-HYDROXYLATION; HEPATIC CYTOCHROME-P-450 ISOZYMES; STRUCTURALLY RELATED ENZYMES; RAT-LIVER; CATALYTIC ACTIVITY; UNTREATED RAT; FORM RLM2; REGIOSELECTIVITY; PURIFICATION; P-450 C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. RP WAXMAN, DJ (reprint author), HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115, USA. FU NIDDK NIH HHS [R01 DK033765, DK-33765] NR 18 TC 71 Z9 71 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0076-6879 J9 METHOD ENZYMOL JI Method Enzymol. PY 1991 VL 206 BP 462 EP 476 PG 15 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA HG720 UT WOS:A1991HG72000044 PM 1784231 ER PT J AU HUSTON, JS MUDGETTHUNTER, M TAI, MS MCCARTNEY, J WARREN, F HABER, E OPPERMANN, H AF HUSTON, JS MUDGETTHUNTER, M TAI, MS MCCARTNEY, J WARREN, F HABER, E OPPERMANN, H TI PROTEIN ENGINEERING OF SINGLE-CHAIN FV ANALOGS AND FUSION PROTEINS SO METHODS IN ENZYMOLOGY LA English DT Article ID IMMUNOGLOBULIN VARIABLE DOMAINS; SODIUM DODECYL SULFATE; HIGH-LEVEL EXPRESSION; ESCHERICHIA-COLI; ANTIGEN-BINDING; 3-DIMENSIONAL STRUCTURE; RECOMBINANT IMMUNOTOXIN; ANTIBODY FRAGMENT; MYELOMA CELLS; LIGHT CHAINS C1 CREAT BIOMOLECULES INC, HOPKINTON, MA 01748 USA. HARVARD UNIV, SCH MED, MASSACHUSETTS GEN HOSP, BOSTON, MA 02115 USA. BRISTOL MYERS SQUIBB PHARMACEUT RES INST, PRINCETON, NJ 08543 USA. NR 128 TC 2 Z9 2 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0076-6879 J9 METHOD ENZYMOL JI Methods Enzymol. PY 1991 VL 203 BP 46 EP + PG 1 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA HG716 UT WOS:A1991HG71600003 ER PT J AU WHITE, MF BACKER, JM AF WHITE, MF BACKER, JM TI PREPARATION AND USE OF ANTI-PHOSPHOTYROSINE ANTIBODIES TO STUDY STRUCTURE AND FUNCTION OF INSULIN-RECEPTOR SO METHODS IN ENZYMOLOGY LA English DT Review ID TYROSINE KINASE; PHOSPHATIDYLINOSITOL KINASE; INTACT-CELLS; PHOSPHORYLATION; TRANSFORMATION; SUBSTRATE; PROTEIN RP WHITE, MF (reprint author), JOSLIN DIABET CTR,DIV RES,BOSTON,MA 02215, USA. FU NIDDK NIH HHS [DK38712, DK08126, DK36836] NR 15 TC 29 Z9 29 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0076-6879 J9 METHOD ENZYMOL JI Method Enzymol. PY 1991 VL 201 BP 65 EP 79 PG 15 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GN468 UT WOS:A1991GN46800007 PM 1719349 ER PT J AU MACLAUGHLIN, DT EPSTEIN, J DONAHOE, PK AF MACLAUGHLIN, DT EPSTEIN, J DONAHOE, PK TI BIOASSAY, PURIFICATION, CLONING, AND EXPRESSION OF MULLERIAN INHIBITING SUBSTANCE SO METHODS IN ENZYMOLOGY LA English DT Review ID GRANULOSA-CELLS; FETAL TESTIS; RIBONUCLEIC-ACID; DUCT REGRESSION; OOCYTE MEIOSIS; RAT OVARY; HORMONE; INVITRO; BOVINE; GROWTH RP MASSACHUSETTS GEN HOSP, PEDIAT SURG RES LAB, BOSTON, MA 02114 USA. NR 50 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0076-6879 J9 METHOD ENZYMOL JI Methods Enzymol. PY 1991 VL 198 BP 358 EP 369 PG 12 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GM724 UT WOS:A1991GM72400035 ER PT J AU JANMEY, PA AF JANMEY, PA TI POLYPROLINE AFFINITY METHOD FOR PURIFICATION OF PLATELET PROFILIN AND MODIFICATION WITH PYRENE MALEIMIDE SO METHODS IN ENZYMOLOGY LA English DT Review ID LOW-MOLECULAR WEIGHT; ACANTHAMOEBA PROFILIN; CHICK-EMBRYOS; ACTIN; PROFILACTIN; PROTEIN; ISOFORMS; GELSOLIN; SEQUENCE; BINDING RP HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT BIOL CHEM & MOLEC PHARMACOL, HEMATOL UNIT, BOSTON, MA 02129 USA. NR 26 TC 0 Z9 0 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0076-6879 J9 METHOD ENZYMOL JI Methods Enzymol. PY 1991 VL 196 BP 92 EP 99 PG 8 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FN841 UT WOS:A1991FN84100010 ER PT J AU GALLO, GJ SCHUETZ, TJ KINGSTON, RE AF GALLO, GJ SCHUETZ, TJ KINGSTON, RE TI REGULATION OF HEAT-SHOCK FACTOR IN SCHIZOSACCHAROMYCES-POMBE MORE CLOSELY RESEMBLES REGULATION IN MAMMALS THAN IN SACCHAROMYCES-CEREVISIAE SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID TRANSCRIPTION FACTOR; ACTIVATOR PROTEIN; BINDING-PROTEIN; DNA-BINDING; HUMAN HSP70; YEAST; GENE; PROMOTER; SEQUENCE; PURIFICATION AB The heat shock response appears to be universal. All eucaryotes studied encode a protein, heat shock factor (HSF), that is believed to regulate transcription of heat shock genes. This protein binds to a regulatory sequence, the heat shock element, that is absolutely conserved among eucaryotes. We report here the identification of HSF in the fission yeast Schizosaccharomyces pombe. HSF binding was not observed in extracts from normally growing S. pombe (28-degrees-C) but was detected in increasing amounts as the temperature of heat shock increased between 39 and 45-degrees-C. This regulation is in contrast to that observed in Saccharomyces cerevisiae, in which HSF binding is detectable at both normal and heat shock temperatures. The S. pombe factor bound specifically to the heat shock element, as judged by methylation interference and DNase I protection analysis. The induction of S. pombe HSF was not inhibited by cycloheximide, suggesting that induction occurs posttranslationally, and the induced factor was shown to be phosphorylated. S. pombe HSF was purified to near homogeneity and was shown to have an apparent mobility of approximately 108 kDa. Since heat-induced DNA binding by HSF had previously been demonstrated only in metazoans, the conservation of heat-induced DNA binding by HSF among S. pombe and metazoans suggests that this mode of regulation is evolutionarily ancient. C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115. FU NIGMS NIH HHS [5 F32 GM12865-02] NR 34 TC 50 Z9 50 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD JAN PY 1991 VL 11 IS 1 BP 281 EP 288 PG 8 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA ER081 UT WOS:A1991ER08100031 PM 1986225 ER PT J AU SCHULTES, NP SZOSTAK, JW AF SCHULTES, NP SZOSTAK, JW TI A POLY(DA-DT) TRACT IS A COMPONENT OF THE RECOMBINATION INITIATION SITE AT THE ARG4 LOCUS IN SACCHAROMYCES-CEREVISIAE SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID MEIOTIC GENE CONVERSION; RNA POLYMERASE-I; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; RIBOSOMAL DNA; YEAST; SEQUENCES; TRANSCRIPTION; PROTEIN; MUTAGENESIS; SELECTION AB An initiation site for meiotic gene conversion is located in the promoter region of the ARG4 locus in Saccharomyces cerevisiae. We have tested the hypothesis that the initiation site is identical with the promoter by making a series of small deletions that remove specific promoter elements. Disruption of most promoter elements does not lower the level of gene conversion in ARG4, and analysis of RNA levels at the time of recombination in meiosis reveals no direct correlation between the level of ARG4 transcript and the level of gene conversion in ARG4. However, deletion of a tract of 14 A residues located at the peak of the gene conversion gradient decreases the number of gene conversion events stimulated by the initiation site to 25 to 35% of the normal level. We conclude that the poly(dA . dT) tract is responsible for most but not all the high levels of meiotic gene conversion observed in ARG4. C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. NR 38 TC 94 Z9 95 U1 2 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD JAN PY 1991 VL 11 IS 1 BP 322 EP 328 PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA ER081 UT WOS:A1991ER08100035 PM 1986228 ER PT B AU KOSKI, G LAWRENCE, K RIGHI, D AF KOSKI, G LAWRENCE, K RIGHI, D BE RUBIN, E MILLER, KW ROTH, SH TI INHIBITION BY ETHANOL OF 45CA2+ UPTAKE IN PC12 PHEOCHROMOCYTOMA CELLS - INTERACTIONS BETWEEN ALCOHOL AND CARBACHOL SO MOLECULAR AND CELLULAR MECHANISMS OF ALCOHOL AND ANESTHETICS SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Note CT CONF ON MOLECULAR AND CELLULAR MECHANISMS OF ALCOHOL AND ANESTHETICS CY JUN 25-28, 1990 CL CALGARY, CANADA SP NEW YORK ACAD SCI, NIAAA RP KOSKI, G (reprint author), HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,BIOCHEM PHARMACOL LAB,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-662-3 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 625 BP 448 EP 450 DI 10.1111/j.1749-6632.1991.tb33876.x PG 3 WC Anesthesiology; Biochemistry & Molecular Biology; Substance Abuse; Physiology SC Anesthesiology; Biochemistry & Molecular Biology; Substance Abuse; Physiology GA BT99V UT WOS:A1991BT99V00052 PM 2058900 ER PT B AU MILLER, KW WOOD, SC FORMAN, SA BUGGE, B HILL, WAG ABADJI, V AF MILLER, KW WOOD, SC FORMAN, SA BUGGE, B HILL, WAG ABADJI, V BE RUBIN, E MILLER, KW ROTH, SH TI THE NICOTINIC ACETYLCHOLINE-RECEPTOR IN ITS MEMBRANE ENVIRONMENT SO MOLECULAR AND CELLULAR MECHANISMS OF ALCOHOL AND ANESTHETICS SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON MOLECULAR AND CELLULAR MECHANISMS OF ALCOHOL AND ANESTHETICS CY JUN 25-28, 1990 CL CALGARY, CANADA SP NEW YORK ACAD SCI, NIAAA ID POSTSYNAPTIC MEMBRANES; ION CHANNEL; TORPEDO; ANESTHETICS; INHIBITION; INCREASES; PROTEINS; PROCAINE; AGONIST; ETHANOL RP MILLER, KW (reprint author), MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,BOSTON,MA 02114, USA. FU NIAAA NIH HHS [AA 07040]; NIGMS NIH HHS [GM 15904] NR 0 TC 14 Z9 14 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-662-3 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 625 BP 600 EP 615 DI 10.1111/j.1749-6632.1991.tb33895.x PG 16 WC Anesthesiology; Biochemistry & Molecular Biology; Substance Abuse; Physiology SC Anesthesiology; Biochemistry & Molecular Biology; Substance Abuse; Physiology GA BT99V UT WOS:A1991BT99V00071 PM 1711816 ER PT B AU BADEN, HP AF BADEN, HP BE STENN, KS MESSENGER, AG BADEN, HP TI WHERE WE HAVE BEEN AND WHERE WE SHOULD BE - CLINICAL RELEVANCE OF THE MOLECULAR AND STRUCTURAL BIOLOGY OF HAIR SO MOLECULAR AND STRUCTURAL BIOLOGY OF HAIR SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Editorial Material CT CONF ON THE MOLECULAR AND STRUCTURAL BIOLOGY OF HAIR CY JAN 23-25, 1991 CL ARLINGTON, VA SP NEW YORK ACAD SCI, NIAMSD, NICHHD, ROCHE DERMATOL, GILLETTE, GLAXO RES LABS, LOREAL, MERCK SHARP & DOHME RES LABS, R W JOHNSON PHARM RES INST, REVLON RES CTR RP BADEN, HP (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT DERMATOL,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-692-5 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 642 BP 435 EP 435 PG 1 WC Anatomy & Morphology; Biochemistry & Molecular Biology; Physiology SC Anatomy & Morphology; Biochemistry & Molecular Biology; Physiology GA BW41K UT WOS:A1991BW41K00034 ER PT J AU BUBLEY, GJ ASHBURNER, BP TEICHER, BA AF BUBLEY, GJ ASHBURNER, BP TEICHER, BA TI SPECTRUM OF CIS-DIAMMINEDICHLOROPLATINUM(II) INDUCED MUTATIONS IN A SHUTTLE VECTOR PROPAGATED IN HUMAN-CELLS SO MOLECULAR CARCINOGENESIS LA English DT Article DE CISPLATIN; MUTAGENESIS; REPLICATION MAPPING; MUTATIONAL HOT SPOTS ID INVITRO DNA-SYNTHESIS; ESCHERICHIA-COLI; XERODERMA-PIGMENTOSUM; POINT MUTATIONS; CYTO-TOXICITY; STRANDED-DNA; CISPLATIN; SPECIFICITY; ADDUCTS; GENE AB The supF gene of the shuttle vector pZ189 was used as a target for the study of mutations induced by cis-diamminedichloroplatinum(II) (cis-DDP). Normal human repair-proficient fibroblasts and cis-DDP repair-deficient xeroderma pigmentosum (XP) cells were used as host cells to study the effect of cis-DDP on the inhibition of shuttle vector replication and mutagenesis. Transfection of cis-DDP-treated pZ189 into normal and XP cell lines resulted in a marked increase in the mutation frequency and a decrease in the replication efficiency of the vector. However, these effects were much greater for the plasmid propagated in XP cells. Atomic absorption spectroscopy showed that six to eight Pt-DNA adducts per plasmid were necessary to inhibit plasmid replication by 50% in normal cells. In contrast, only one to two Pt-DNA adducts were necessary to inhibit replication of the plasmid by 50% in XP cells. Analysis of mutation sites demonstrated that cis-DDP treatment resulted primarily in single and double mutations separated by one base and limited to a few locations within the 85-bp mature tRNA. Propagation of the cis-DDP-treated vector in either normal or XP cells led to predominantly transversion mutations at AGA, AGG, and GAG sites and a cis-DDP-associated deletion of 174 bp. Although mutations occurred at target sites for cis-DDP adduct formation, there was no correlation between sites of mutation and the most frequent sites of adduct formation. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. BETH ISRAEL HOSP,HARVARD THORNDIKE LAB,CHARLES A DANA RES INST,BOSTON,MA 02215. FU NCI NIH HHS [CA-36508, CA-38493, CA-01022] NR 50 TC 42 Z9 42 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0899-1987 J9 MOL CARCINOGEN JI Mol. Carcinog. PY 1991 VL 4 IS 5 BP 397 EP 406 DI 10.1002/mc.2940040512 PG 10 WC Biochemistry & Molecular Biology; Oncology SC Biochemistry & Molecular Biology; Oncology GA GJ829 UT WOS:A1991GJ82900011 PM 1910483 ER PT J AU RAM, PA WAXMAN, DJ AF RAM, PA WAXMAN, DJ TI HEPATIC P450 EXPRESSION IN HYPOTHYROID RATS - DIFFERENTIAL RESPONSIVENESS OF MALE-SPECIFIC P450 FORM-2A (IIIA2), FORM-2C (IIC11), AND RLM2 (IIA2) TO THYROID-HORMONE SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID GROWTH-HORMONE; GENE CONVERSION; MESSENGER-RNA; PITUITARY; LIVER; CYTOCHROME-P-450; TESTOSTERONE; SUPPRESSION; ENZYME; TRIIODOTHYRONINE AB Studies carried out in hypophysectomized adult rats have demonstrated that both thyroid hormone and GH can suppress hepatic expression of the steroid 6-beta-hydroxylase P450 2a (IIIA2). The present study further characterizes the influence of thyroid hormone on the expression of P450 2a and two other male-specific hepatic P450s, a steroid 2-alpha/16-alpha-hydroxylase, designated P450 2c (IIC11), and a steroid 15-alpha-hydroxylase, designated P450 RLM2 (IIA2). These studies were carried out in rats rendered hypothyroid by treatment with methimazole, which allows for the nonsurgical depletion of circulating T4, and in hypophysectomized rats. Hypothyroidism led to an increase in hepatic P450 2a (IIIA2) protein and mRNA in both male and female rats that was fully reversed by T4 replacement. In contrast, hypothyroidism decreased by 70-80% the expression of P450 2c (IIC11) activity and mRNA, but did not significantly alter the expression of P450 RLM2 (IIA2). The decrease in P450 2c (IIC11) was not reversed by T4 replacement, suggesting that it is a consequence of the loss of plasma GH pulses that occurs secondary to hypothyroidism. In agreement with these findings, T4 given to hypophysectomized rats partially suppressed the expression of P450 2a (IIIA2) mRNA, but not P450 2c (IIC11) or P450 RLM2 (IIA2) mRNA. A more complete suppression of P450 2a (IIIA2) mRNA as well as P450 2c (IIC11) mRNA was achieved when the hypophysectomized rats were treated with T3 at a supraphysiological, receptor-saturating dose. Although GH administered to intact male rats by continous infusion fully suppressed all three male-specific P450 proteins and their mRNAs, the same treatment given to hypothyroid rats was only partially suppressive in the case of P450 2a (IIIA2) and P450 RLM2 (IIA2), unless combined with T4. In the case of P450 2c (IIC11), substantial suppression of the residual P450 present in hypothyroid rats was achieved by treatment with GH alone, despite persistent thyroid hormone deficiency. These studies demonstrate that while thyroid hormone is a negative regulator of P450 2a (IIIA2) expression and is required for the full suppression of that P450 and P450 RLM2 (IIA2) by the continuous plasma GH profiles associated with adult female rats, the suppression of P450 2c (IIC11) by continuous plasma GH is largely independent of the presence of thyroid hormone. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT BIOL CHEM & MOLEC PHARMACOL,JF-525,44 BINNEY ST,BOSTON,MA 02115. FU NIDDK NIH HHS [R01 DK033765, DK-33765] NR 36 TC 59 Z9 59 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD JAN PY 1991 VL 5 IS 1 BP 13 EP 20 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EW188 UT WOS:A1991EW18800003 PM 2017188 ER PT J AU HAUGUELDEMOUZON, S KAHN, CR AF HAUGUELDEMOUZON, S KAHN, CR TI INSULIN-LIKE GROWTH FACTOR-MEDIATED PHOSPHORYLATION AND PROTOONCOGENE INDUCTION IN MADIN-DARBY CANINE KIDNEY-CELLS SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID STIMULATES TYROSINE PHOSPHORYLATION; FACTOR-I-RECEPTOR; HUMAN PLACENTAL MEMBRANES; SKELETAL-MUSCLE CELLS; H-35 HEPATOMA-CELLS; MR 185,000 PROTEIN; C-FOS GENE; INTACT-CELLS; DNA-SYNTHESIS; KINASE AB We have characterized the role of tyrosine phosphorylation in protooncogene induction mediated by insulin-like growth factors I and II (IGF-I and IGF-II) in the Madin-Darby canine kidney (MDCK) cell line. These cells possess few, if any, insulin receptors, thus allowing determination of the effects of these growth factors in the absence of any secondary signal mediated through the insulin receptor. We found that IGF-I produced a specific stimulation of tyrosine kinase activity of the 97-kDa beta-subunit of the IGF-I receptor, resulting in autophosphorylation of the receptor and an increase in kinase activity toward a synthetic peptide substrate. This was associated with a gradual decrease in the level of phosphorylation of pp 120, the major constitutive phosphotyrosine-containing protein of MDCK cells, and an increase in the ratio of serine to tyrosine phosphorylation. This was followed by a rapid, but transient, induction of c-fos gene expression, with no change in the levels of c-myc mRNA. Cycloheximide treatment resulted in a superinduction of both c-fos and c-myc and prevented any further stimulation by IGF-I. IGF-II did not stimulate tyrosine phosphorylation of its own receptor, but was 25% as active as IGF-I in stimulating phosphorylation of the IGF-I receptor. Despite this, IGF-II did not significantly enhance the expression of either nuclear protooncogene. Insulin also produced a delayed stimulation of IGF-I receptor phosphorylation, but was unable to stimulate biological effects in these cells. Under these conditions neither of the IGFs nor insulin produced any significant stimulation of thymidine incorporation into DNA. These data indicate that the IGF-I receptor can be activated upon binding of IGF-I, and to a lesser extent IGF-II, in intact cells to mediate cellular events. The nature of the signal generated by the IGF-I receptor appears to vary depending on the ligand that occupies it. C1 BRIGHAM & WOMENS HOSP,DEPT MED,JOSLIN DIABET CTR,DIV RES,1 JOSLIN PL,BOSTON,MA 02215. HARVARD UNIV,SCH MED,BOSTON,MA 02215. FU NIDDK NIH HHS [DK-33201, DK-36836] NR 48 TC 19 Z9 19 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD JAN PY 1991 VL 5 IS 1 BP 51 EP 60 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EW188 UT WOS:A1991EW18800008 PM 1708099 ER PT J AU CHATTERJEE, VKK MADISON, LD MAYO, S JAMESON, JL AF CHATTERJEE, VKK MADISON, LD MAYO, S JAMESON, JL TI REPRESSION OF THE HUMAN GLYCOPROTEIN HORMONE ALPHA-SUBUNIT GENE BY GLUCOCORTICOIDS - EVIDENCE FOR RECEPTOR INTERACTIONS WITH LIMITING TRANSCRIPTIONAL ACTIVATORS SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID CAMP-RESPONSIVE ENHANCER; PROTEIN-BINDING DOMAINS; CYCLIC-AMP; THYROID-HORMONE; PROLACTIN GENE; NUCLEOTIDE-SEQUENCE; MAMMALIAN-CELLS; EXPRESSION; ELEMENTS; DNA AB Expression of the glycoprotein hormone alpha-gene is regulated divergently by glucocorticoids in different cell types. Coexpression of the glucocorticoid receptor (GR) with an alpha-CAT reporter gene caused activation of alpha promoter activity in fibroblasts, but repression in JEG-3 choriocarcinoma cells, indicating that cell-specific factors dictate positive vs. negative regulation of this promoter by GR. Cell-specific sequences and other enhancer elements in the the alpha gene have been relatively well characterized in JEG-3 cells, and this model was used to further examine the mechanism of transcriptional repression by glucocorticoids. Promoter mutagenesis indicated that the degree of GR-mediated repression was impaired by a variety of deletional and site-directed mutations between -171 and -111 bp, a region that includes both cell-specific and cAMP response elements (CREs). In an attempt to further localize a negative glucocorticoid response element (GRE) sequence, binding studies were used to assess GR interactions with alpha promoter DNA sequences. Using avidin-biotin complex DNA binding assays, a series of overlapping alpha promoter DNA sequences between -170 to 29 basepairs were tested, but each failed to bind GR, whereas a control GRE avidly bound receptor. Similarly, in competition assays in transfected CV-1 cells, the alpha gene 5'-flanking sequence did not compete for GR stimulation of a glucocorticoid responsive reporter gene, whereas a sequence that contains known GR-binding sites (murine mammary tumor virus) effectively inhibited GR-mediated expression. The absence of high affinity GR-binding sites in the alpha promoter suggested that mutations that affected GR inhibition may have eliminated recognition sites for transactivators, which are themselves targets for the GR, rather than altering specific negative GRE sites in the DNA sequence. To examine this possibility, GR repression was studied using chimeric transcription factors. The transcription-activating domains of several different proteins (CREB, thyroid hormone receptor, or VP16) were linked to the DNA-binding domain of Gal-4, and transcription was driven by the Gal-4 recognition site (UAS). GR markedly repressed transactivation by Gal-4-CREB and, to a lesser degree, the Gal-4-thyroid hormone receptor and Gal-4-VP16 chimeric proteins. Repression occurred when UAS was linked to either the alpha promoter or to the E1B promoter. Thus, inhibition occurs in the absence of either the CRE or the proximal alpha promoter. These results support a mechanism in which GR-mediated repression in JEG-3 cells occurs by receptor interference with the transactivating potential of enhancer-binding proteins or associated transcription factors. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,THYROID UNIT,BOSTON,MA 02114. OI Jameson, James/0000-0001-9538-4059 FU NICHD NIH HHS [HD-23519]; NIDDK NIH HHS [DK-42144] NR 55 TC 65 Z9 65 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD JAN PY 1991 VL 5 IS 1 BP 100 EP 110 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EW188 UT WOS:A1991EW18800013 PM 1708098 ER PT J AU LANTZ, M LINDVALL, L PANTAZIS, P OLSSON, I AF LANTZ, M LINDVALL, L PANTAZIS, P OLSSON, I TI LYMPHOTOXIN PRODUCED BY HUMAN B-CELL AND T-CELL LINES APPEARS IN 2 DISTINCT FORMS SO MOLECULAR IMMUNOLOGY LA English DT Article ID TUMOR NECROSIS FACTOR; HUMAN LT SYSTEM; INTERFERON-GAMMA; GROWTH-FACTOR; FACTORS-ALPHA; VIRUS; LYMPHOCYTES; INVITRO; COMPLEX; TNF AB Production and release of lymphotoxin (LT) was studied by metabolic labeling of human B- and T-cell lines with C-14-leucine and S-35-methionine. LT was immunoprecipitated with antiserum to LT and separated by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis (PAGE) followed by fluorography. Two molecular weight forms of LT with different rates of release were found both in cell supernatants and cell extracts. Monensin, a sodium ionophore, inhibited the release of LT. LT still appeared in two molecular weight forms after deglycosylation with N-glycanase. Treatment of cells with swainsonine followed by digestion of released LT with endoglycosidase H (endo H) demonstrated that the oligosaccharides were of the complex type. Subcellular fractionation of cells on Percoll density gradients demonstrated that intracellular LT is located to intermediate density fractions. No LT was found in the high density fractions corresponding to lysosomes. Phorbol 12-myristate 13-acetate induced production of tumor necrosis factor (TNF) in the B-lymphoblastoid cell line RPMI-1788. In conclusion, we have demonstrated the presence of two distinct molecular weight forms of LT, which contain N-linked oligosaccharides of the complex type. C1 CTR BLOOD RES,BOSTON,MA 02115. RP LANTZ, M (reprint author), UNIV LUND,DEPT MED,DIV HEMATOL,S-22185 LUND,SWEDEN. NR 31 TC 4 Z9 4 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD JAN-FEB PY 1991 VL 28 IS 1-2 BP 9 EP 16 DI 10.1016/0161-5890(91)90081-T PG 8 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA FD122 UT WOS:A1991FD12200002 PM 2011132 ER PT B AU GUSELLA, JF SEIZINGER, BR ROULEAU, G MENON, A FONTAINE, B MARTUZA, RL AF GUSELLA, JF SEIZINGER, BR ROULEAU, G MENON, A FONTAINE, B MARTUZA, RL BE BERGSAGEL, DE MAK, TW TI MOLECULAR GENETIC-ANALYSIS OF THE PHAKOMATOSES SO MOLECULAR MECHANISMS AND THEIR CLINICAL APPLICATION IN MALIGNANCIES SE BRISTOL-MYERS SQUIBB CANCER SYMPOSIA LA English DT Proceedings Paper CT 12TH ANNUAL BRISTOL-MYERS SQUIBB SYMP ON CANCER RESEARCH : MOLECULAR MECHANISMS AND THEIR CLINICAL APPLICATIONS IN MALIGNANCIES CY SEP 26-27, 1989 CL TORONTO, CANADA SP ONTARIO CANC INST, PRINCESS MARGARET HOSP, BRISTOL MYERS SQUIBB RP GUSELLA, JF (reprint author), MASSACHUSETTS GEN HOSP,CTR NEUROSCI,MOLEC NEUROGENET LAB,BOSTON,MA 02129, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC PI SAN DIEGO PA SAN DIEGO BN 0-12-091075-6 J9 BRIS MYER C PY 1991 VL 12 BP 1 EP 16 PG 16 WC Biochemistry & Molecular Biology; Oncology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Oncology; Pharmacology & Pharmacy GA BU44X UT WOS:A1991BU44X00001 ER PT J AU DELEON, D BRIN, MF MURPHY, P BRESSMAN, SB OZELIUS, L CARDON, N REICH, S BREAKEFIELD, XO FAHN, S AF DELEON, D BRIN, MF MURPHY, P BRESSMAN, SB OZELIUS, L CARDON, N REICH, S BREAKEFIELD, XO FAHN, S TI GENETIC-COUNSELING FOR IDIOPATHIC TORSION DYSTONIA - 1ST USE OF DNA BASED CARRIER DETECTION IN ASHKENAZI JEWS SO MOVEMENT DISORDERS LA English DT Meeting Abstract C1 COLUMBIA PRESBYTERIAN MED CTR,NEW YORK,NY 10032. NEW YORK STATE DEPT HLTH,DNA DIAGNOST LAB,ALBANY,NY 12201. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. BOOTH MEM MED CTR,FLUSHING,NY. NR 0 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0885-3185 J9 MOVEMENT DISORD JI Mov. Disord. PY 1991 VL 6 IS 3 BP 273 EP 274 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA FW226 UT WOS:A1991FW22600030 ER PT J AU FABER, R TRIMBLE, MR AF FABER, R TRIMBLE, MR TI ELECTROCONVULSIVE-THERAPY IN PARKINSONS-DISEASE AND OTHER MOVEMENT-DISORDERS SO MOVEMENT DISORDERS LA English DT Review DE ELECTROCONVULSIVE THERAPY; MOVEMENT DISORDERS; PARKINSONS DISEASE AB Early case reports note marked improvements in the signs of Parkinson' s disease (PD) in several patients with coexisting psychiatric disorders after treatment with electroconvulsive therapy (ECT). Studies since 1959 reveal improvement of parkinsonism in over half of PD patients receiving ECT, regardless of the presence or absence of psychiatric comorbidity. Drug-induced parkinsonism, tardive dystonia, and tardive dyskinesia have also been shown to improve with ECT administration; tic syndromes have achieved mixed results. In animals, ECT enhances dopamine-mediated effects and increases GABA concentrations in the CNS. Optimal parameters relevant to the antiparkinsonism effects of ECT require further study. RP FABER, R (reprint author), AUDIE L MURPHY MEM VET ADM MED CTR,DEPT PSYCHIAT,7400 MERTON MINTER DR,SAN ANTONIO,TX 78284, USA. NR 0 TC 76 Z9 79 U1 1 U2 4 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0885-3185 J9 MOVEMENT DISORD JI Mov. Disord. PY 1991 VL 6 IS 4 BP 293 EP 303 DI 10.1002/mds.870060405 PG 11 WC Clinical Neurology SC Neurosciences & Neurology GA GN705 UT WOS:A1991GN70500003 PM 1758447 ER PT J AU SHAHANI, BT WIERZBICKA, MM PARKER, SW AF SHAHANI, BT WIERZBICKA, MM PARKER, SW TI ABNORMAL SINGLE MOTOR UNIT BEHAVIOR IN THE UPPER MOTOR-NEURON SYNDROME SO MUSCLE & NERVE LA English DT Article DE MOTOR UNIT; UPPER MOTONEURON; SPASTICITY ID MAXIMAL VOLUNTARY CONTRACTIONS; FIRING PATTERN; IMPAIRED REGULATION; DISCHARGE PATTERN; MUSCLES; TREMOR; RATES AB We studied the discharge pattern of single motor units (SMUs) in the left and right biceps muscles from a patient with nonspastic weakness of the left arm. Detailed statistical analysis of the behavior of discharge patterns of 4 of 4 single motor units on the affected side showed abnormalities with characteristic features of an upper motor neuron lesion. Five out of 5 single motor units recorded from the right biceps were normal. An upper motor neuron lesion affecting the left arm, predicted by our results, was confirmed by magnetic resonance imaging (MRI), which showed a lesion in the right precentral gyrus. It appears that changes in single motor unit firing characteristics, caused by an upper motor neuron lesion, can be detected at a time when there is no evidence of increased "tone" and/or hyperreflexia (spasticity) in the affected extremity. C1 HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115. RP SHAHANI, BT (reprint author), MASSACHUSETTS GEN HOSP,CLIN NEUROPHYSIOL LAB,BIGELOW 12,BOSTON,MA 02114, USA. NR 17 TC 11 Z9 11 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD JAN PY 1991 VL 14 IS 1 BP 64 EP 69 DI 10.1002/mus.880140111 PG 6 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EN805 UT WOS:A1991EN80500010 PM 1992298 ER PT J AU MACIEJEWSKI, B SKLADOWSKI, K ZAJUSZ, A AF MACIEJEWSKI, B SKLADOWSKI, K ZAJUSZ, A TI RADIOBIOLOGICAL PREDICTORS OF TUMOR AND ACUTE NORMAL TISSUE-RESPONSE IN RADIOTHERAPY FOR HEAD AND NECK CANCERS SO NEOPLASMA LA English DT Article DE RADIOBIOLOGICAL PREDICTORS; HEAD NECK CANCERS ID SQUAMOUS-CELL CARCINOMA; DOSE FRACTIONATION; ORAL CAVITY; TIME; RADIOSENSITIVITY; REGENERATION; REPOPULATION; OROPHARYNX; LARYNX; ASSAY AB Importance of two assay of the measurements of potential doubling time (T(pot.)) and survival fraction at 2.0 Gy (SF2) and a method modifying acute radiation response of normal oral mucosa are discussed. Tumor clonogen repopulation accelerates around day 28 of treatment and the rate of repopulation is not constant but continuously increases from about 0.3 Gy/day to 1.0-1.3 Gy/day between day 28 and 65 of treatment. It may suggest that T(pot.) values decrease respectively. The relevance of the T(pot.) measurements prior to the treatment to clinical situations is discussed. The SF2 value reflects the intrinsic radiosensitivity of human tumors. The SF2 values are expected to be valuable as a predictors for tumor response to radiation. Variations in the SF2 values depending on tumor characteristics and assay methods are discussed in relation to the dose-response and tumor cure probability. The effect of modification of an accelerate repopulation in the oral mucosa by stimulation with 2% silver nitrate solution is presented. Although the presented prognosticators are different in their nature, they might provide a rational basis for selecting patients into optimal radiation treatment and might allow to modify radiation response of dose-limiting normal tissues. C1 INST ONCOL,CTR RADIOTHERAPY CLIN CANC,PL-44101 GLIWICE,POLAND. RP MACIEJEWSKI, B (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,CTR CANC,DEPT RADIAT MED,BOSTON,MA 02114, USA. NR 28 TC 1 Z9 1 U1 1 U2 1 PU SLOVAK ACADEMIC PRESS LTD PI BRATISLAVA PA PO BOX 57, NAM SLOBODY 6, 810 05 BRATISLAVA, SLOVAKIA SN 0028-2685 J9 NEOPLASMA JI Neoplasma PY 1991 VL 38 IS 5 BP 513 EP 522 PG 10 WC Oncology SC Oncology GA GN659 UT WOS:A1991GN65900008 PM 1956467 ER PT J AU FILLINGKATZ, MR CHOYKE, PL OLDFIELD, E CHARNAS, L PATRONAS, NJ GLENN, GM GORIN, MB MORGAN, JK LINEHAN, WM SEIZINGER, BR ZBAR, B AF FILLINGKATZ, MR CHOYKE, PL OLDFIELD, E CHARNAS, L PATRONAS, NJ GLENN, GM GORIN, MB MORGAN, JK LINEHAN, WM SEIZINGER, BR ZBAR, B TI CENTRAL-NERVOUS-SYSTEM INVOLVEMENT IN VONHIPPEL-LINDAU DISEASE SO NEUROLOGY LA English DT Article C1 NEI,CLIN SERV,BETHESDA,MD 20892. NIH,BETHESDA,MD 20892. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,CAMBRIDGE,MA 02138. WARREN G MAGNUSSON CLIN CTR,DEPT RADIOL,BETHESDA,MD. UNIV LOUISVILLE,DEPT OPHTHALMOL,LOUISVILLE,KY 40292. UNIV LOUISVILLE,DEPT NEUROL,LOUISVILLE,KY 40292. NICHHD,HUMAN GENET BRANCH,NEUROGENET UNIT,BETHESDA,MD 20892. NINCDS,SURG NEUROL BRANCH,BETHESDA,MD 20892. NCI,SURG BRANCH,IMMUNOBIOL LAB,BETHESDA,MD 20892. NEI,CLIN BRANCH OPHTHALM GENET,BETHESDA,MD 20892. NR 8 TC 103 Z9 107 U1 0 U2 1 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0028-3878 J9 NEUROLOGY JI Neurology PD JAN PY 1991 VL 41 IS 1 BP 41 EP 46 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA ER633 UT WOS:A1991ER63300009 PM 1985294 ER PT J AU KULA, NS BALDESSARINI, RJ AF KULA, NS BALDESSARINI, RJ TI LACK OF INCREASE IN DOPAMINE TRANSPORTER BINDING OR FUNCTION IN RAT-BRAIN TISSUE AFTER TREATMENT WITH BLOCKERS OF NEURONAL UPTAKE OF DOPAMINE SO NEUROPHARMACOLOGY LA English DT Note DE DOPAMINE; STIMULANTS; TRANSPORTER; UPTAKE ID RECEPTOR-SITES; STRIATUM AB Rats were pretreated daily for 10 days with a dopamine (DA) uptake blocker ([+]amphetamine, benztropine, cocaine, GBR-12909, mazindol, or nomifensine) or control vehicle and, after 1-4 days of no treatment, striatal tissue was fractionated to provide synaptosomes and membranes for assay of transport of 3H-DA or binding of 3H-GBR-12935. There were no significant increases of apparent maxima for uptake (V(max)) or binding (B(max)) or consistent changes in ligand affinity. Pharmacologic characterization of 3H-GBR-12935 binding extended the impression that this ligand has high affinity and selectivity for many agents which block neuronal uptake of DA uptake and much less for those which interact with DA receptors or other amine transporters. The results suggest that dopamine transporters are not regulated in the same way as receptors, nor influenced similarly toward upregulation and supersensitization by repeated treatment with antagonists. C1 HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,MCLEAN DIV,MAILMAN RES CTR,DEPT PSYCHIAT,BOSTON,MA 02114. FU NIMH NIH HHS [MH-34006, MH-31154, MH-36224] NR 11 TC 80 Z9 82 U1 3 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0028-3908 J9 NEUROPHARMACOLOGY JI Neuropharmacology PD JAN PY 1991 VL 30 IS 1 BP 89 EP 92 DI 10.1016/0028-3908(91)90047-F PG 4 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA EU428 UT WOS:A1991EU42800013 PM 2046881 ER PT J AU BALDESSARINI, RJ KULA, NS GAO, Y CAMPBELL, A NEUMEYER, JL AF BALDESSARINI, RJ KULA, NS GAO, Y CAMPBELL, A NEUMEYER, JL TI R(-)2-FLUORO-N-NORMAL-PROPYLNORAPOMORPHINE - A VERY POTENT AND D2-SELECTIVE DOPAMINE AGONIST SO NEUROPHARMACOLOGY LA English DT Note DE AGONISTS; APORPHINES; D1 AND D2; DOPAMINE; 2-FLUORO-N-NORMAL-PROPYLNORAPOMORPHINE; RECEPTORS ID RAT; RECEPTOR; TISSUE AB A series of 2-substituted N-n-propylnorapomorphine (NPA) derivatives were synthesized and compared with other DA agonists for affinity to D(1) and D(2) dopamine (DA) receptors in rat brain corpus striatum tissue. The 2-substituents tested reduced D(1) affinity similarly, but enhanced D2 affinity in the rank order: F > OH > Br > OCH3 > H greater-than-or-equal-to NH2. The extraodinarily high D2 affinity (K(i) = 12 pM) and D2 vs. D1 selectivity (57,500) of 2-F-NPA far-exceeded that of all other DA agonists tested, and it was about 10-times more potent than NPA in vivo. C1 RES BIOCHEM INC,NATICK,MA 01769. HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,MCLEAN DIV,MAILMAN RES CTR,DEPT PSYCHIAT,BOSTON,MA 02114. RP BALDESSARINI, RJ (reprint author), NORTHEASTERN UNIV,COLL PHARM & ALLIED HLTH PROFESS,MED CHEM SECT,BOSTON,MA 02115, USA. FU NIMH NIH HHS [MH-34006, MH-31154, MH-36224] NR 12 TC 9 Z9 9 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0028-3908 J9 NEUROPHARMACOLOGY JI Neuropharmacology PD JAN PY 1991 VL 30 IS 1 BP 97 EP 99 DI 10.1016/0028-3908(91)90049-H PG 3 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA EU428 UT WOS:A1991EU42800015 PM 1675452 ER PT J AU NEMEROFF, CB KILTS, CD LEVANT, B BISSETTE, G CAMPBELL, A BALDESSARINI, RJ AF NEMEROFF, CB KILTS, CD LEVANT, B BISSETTE, G CAMPBELL, A BALDESSARINI, RJ TI EFFECTS OF THE ISOMERS OF N-NORMAL-PROPYLNORAPOMORPHINE AND HALOPERIDOL ON REGIONAL CONCENTRATIONS OF NEUROTENSIN IN RAT-BRAIN SO NEUROPSYCHOPHARMACOLOGY LA English DT Article DE APORPHINES; HALOPERIDOL; LIMBIC SYSTEM; NEUROTENSIN; N-NORMAL-PROPYLNORAPOMORPHINE ID VENTRAL TEGMENTAL AREA; CENTRAL NERVOUS-SYSTEM; SYNAPTIC-MEMBRANES; DOPAMINE NEURONS; NUCLEUS ACCUMBENS; INDUCED SEDATION; RECEPTORS; DRUGS; TERM; NEUROPEPTIDES AB Rats were treated for 10 days with haloperidol (0.2 or 3 mg/kg/day intraperitoneally [IP]), with either S(+) or R(-) N-n-propylnorapomorphine (NPA; 3 mg/kg IP three times daily) or saline as a placebo control. Brain was microdissected into 11 regions for radioimmunoassay of neurotensin (NT)-like activity under coded ("blind") conditions. Concentrations of NT in rat brain regions ranked central amygdaloid nucleus > ventral bed nucleus > ventral tegmentum > dorsal bed nucleus > arcuate nucleus > substantia nigra > nucleus accumbens septi (accumbens) > piriform cortex > nucleus caudatus (caudate) > mesoprefrontal cortex > cingulate cortex, similar to previous observations. Since untreated and placebo-injected control results were indistinguishable, a stress artifact is unlikely to account for the findings. Haloperidol at the lower dose produced no significant changes but, at the higher dose, yielded relatively large (42%-143%) increases of NT concentrations in accumbens, caudate, and substantia nigra. S(+)NPA, which has some properties as a limbic-selective dopamine antagonist, yielded smaller (55%-66%) but significant average increases of NT in accumbens and piriform cortex, and lesser trends toward increases (40%-51%) in caudate, nigra, and mesoprefrontal cortex-all persisting for 5 days after treatment, whereas the R(-) enantiomer, a potent dopaminergic agonist, increased NT only in nigra (by 112%). These observations confirm previous results with haloperidol and add to the impression that S(+)-NPA shares some properties of atypical antipsychotic agents. C1 DUKE UNIV,MED CTR,DEPT PHARMACOL,DURHAM,NC 27710. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,MAILMAN RES CTR,BELMONT,MA. RP NEMEROFF, CB (reprint author), DUKE UNIV,MED CTR,DEPT PSYCHIAT,BOX 3859,DURHAM,NC 27710, USA. NR 43 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0893-133X J9 NEUROPSYCHOPHARMACOL JI Neuropsychopharmacology PD JAN PY 1991 VL 4 IS 1 BP 27 EP 33 PG 7 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA ER483 UT WOS:A1991ER48300004 PM 1672249 ER PT J AU SCHUMACHER, JM SHORT, MP HYMAN, BT BREAKEFIELD, XO ISACSON, O AF SCHUMACHER, JM SHORT, MP HYMAN, BT BREAKEFIELD, XO ISACSON, O TI INTRACEREBRAL IMPLANTATION OF NERVE GROWTH FACTOR-PRODUCING FIBROBLASTS PROTECTS STRIATUM AGAINST NEUROTOXIC LEVELS OF EXCITATORY AMINO-ACIDS SO NEUROSCIENCE LA English DT Article ID GENETICALLY MODIFIED CELLS; CHOLINERGIC NEURONS; NEUROTROPHIC FACTOR; QUINOLINIC ACID; IBOTENIC ACID; L-DOPA; BRAIN; RAT; LESIONS; GLUTAMATE AB With the exception of L-DOPA pharmacological treatment in Parkinson's disease, the neurodegenerative diseases lack effective treatment. Previous studies of neurodegenerative diseases suggest that symptoms arise secondary to defects in local neuronal circuitry and cannot be treated effectively with systemic drug delivery. Therefore, a promising treatment is the application of fetal or genetically engineering cells which protect or replace neurons in deficient regions. Engineered cells can be derived from cell lines or grown from recipient host fibroblasts or other cells, then modified to produce and secrete substances at a specific area of the brain. A previous study using parallel intracerebral infusions of nerve growth factor and an excitotoxic amino acid into the rat striatum demonstrated a protective effect of nerve growth factor on neurons [Aloe L. (1987) Biotechnology 5, 1085-1086]. In order to further test this paradigm, we have utilized a biological delivery system of nerve growth factor by implanting fibroblasts into the rat striatum which secrete high levels of nerve growth factor, prior to infusing the neurotoxins quinolinate or quisqualate. Animals in this group had smaller lesions than did a group implanted with a similar non-nerve growth factor-producing graft. In addition, marked neuronal sparing was noted within areas of lesions in those animals containing a nerve growth factor-producing graft. These results indicate that implantation of genetically engineered nerve growth factor-secreting cells can be used to protect neurons at a specific target from excitotoxin-induced lesions. C1 MCLEAN HOSP,MAILMAN RES CTR,BELMONT,MA 02178. MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET UNIT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,PROGRAM NEUROSCI,BOSTON,MA 02115. RP SCHUMACHER, JM (reprint author), HARVARD UNIV,SCH MED,NEUROREGENERAT LAB,BELMONT,MA 02178, USA. FU NINDS NIH HHS [NS 24279] NR 34 TC 127 Z9 128 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PY 1991 VL 45 IS 3 BP 561 EP 570 DI 10.1016/0306-4522(91)90271-O PG 10 WC Neurosciences SC Neurosciences & Neurology GA GR449 UT WOS:A1991GR44900006 PM 1837849 ER PT J AU DIMITRIADOU, V BUZZI, MG MOSKOWITZ, MA THEOHARIDES, TC AF DIMITRIADOU, V BUZZI, MG MOSKOWITZ, MA THEOHARIDES, TC TI TRIGEMINAL SENSORY FIBER STIMULATION INDUCES MORPHOLOGICAL-CHANGES REFLECTING SECRETION IN RAT DURA-MATER MAST-CELLS SO NEUROSCIENCE LA English DT Article ID VASOACTIVE INTESTINAL POLYPEPTIDE; CENTRAL NERVOUS-SYSTEM; GENE-RELATED PEPTIDE; NEUROGENIC PLASMA EXTRAVASATION; SUBSTANCE-P; CLUSTER HEADACHE; ULTRASTRUCTURAL CHARACTERISTICS; VASCULAR-PERMEABILITY; DE-GRANULATION; BLOOD-VESSELS AB Mast cells are involved in allergic reactions, but may also participate in neurogenic inflammation. The morphology of mast cells in rat dura mater and tongue was evaluated by histochemistry, as well as by scanning and transmission electron microscopy following unilateral trigeminal ganglion stimulation (5 min, 5 Hz, 5 ms, and 0.02, 0.1 or 1.0 mA). Mast cells in dura and tongue of normal animals were numerous, perivascular and often in close proximity to nerve fibers. After 5 min of electrical stimulation, mast cells contralateral to the stimulation showed histochemical characteristics of normal peripheral tissue mast cells (Safranin-positive), and by electron microscopy appeared homogeneous with numerous intact electron-dense granules. On the stimulated side, however, the staining characteristics of mast cells showed changes indicating progressive intracellular loss of their granular content. In addition, the total number of stainable mast cells decreased at all three stimulus intensities, but reached significance only at 0.1 and 0.02 mA. Ultrastructural evidence of granule changes consistent with secretion were observed although degranulation was not observed until 20 min after stimulation. There were no mast cell changes after electrical trigeminal stimulation in adult rats treated as neonates with capsaicin to destroy small caliber sensory afferent axons. These results suggest that mast cells may secrete in response to electrical stimulation of trigeminal axons, possibly mediated by antidromic release of neuropeptides, and may participate in the development of neurogenic inflammation. C1 TUFTS UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02111. HARVARD UNIV,SCH MED,DEPT NEUROL & NEUROSURG,STROKE RES LAB,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. RI Theoharides, Theoharis/E-5596-2010 FU NINDS NIH HHS [NS21558] NR 103 TC 227 Z9 232 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PY 1991 VL 44 IS 1 BP 97 EP 112 PG 16 WC Neurosciences SC Neurosciences & Neurology GA GA845 UT WOS:A1991GA84500007 PM 1771000 ER PT J AU ARONIN, N CHASE, K SAGAR, SM SHARP, FR DIFIGLIA, M AF ARONIN, N CHASE, K SAGAR, SM SHARP, FR DIFIGLIA, M TI N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION IN THE NEOSTRIATUM INCREASES C-FOS AND FOS-RELATED ANTIGENS SELECTIVELY IN MEDIUM-SIZED NEURONS SO NEUROSCIENCE LA English DT Article ID TRANSCRIPTION FACTOR AP-1; IMMUNOREACTIVE LEU-ENKEPHALIN; EXCITATORY AMINO-ACIDS; CENTRAL NERVOUS-SYSTEM; IMMEDIATE EARLY GENES; HUNTINGTONS-DISEASE; QUINOLINIC ACID; NMDA RECEPTOR; STRIATAL NEURONS; RAT NEOSTRIATUM AB In the neostriatum a selective loss of neurons occurs following exposure to N-methyl-D-aspartate receptor agonists. One hypothesis emerging from this observation is that an excitotoxic process via N-methyl-D-aspartate receptors may contribute to the pathogenesis of Huntington's disease, which is characterized by the loss of medium-sized neurons. However, whether there is a selective distribution of N-methyl-D-aspartate receptors in specific populations of neostriatal neurons is unknown. In this study the expression of c-fos mRNA and protein was used to examine the response of neostriatal cells to N-methyl-D-aspartate receptor stimulation in the rat. After intrastriatal injection of the N-methyl-D-aspartate receptor agonist, quinolinic acid, an increase in c-fos mRNA concentrations was detected using in situ hybridization and Northern blot analysis. Western blot analysis showed that not only the c-Fos mRNA protein product but also other Fos-related antigens capable of binding to DNA were increased in response to N-methyl-D-aspartate receptor activation. The selectivity of the neuronal response to N-methyl-D-aspartate receptor activation was examined immunohistochemically at the light and ultrastructural levels. Our results indicate that N-methyl-D-aspartate receptor activation by quinolinic acid stimulates medium spiny neurons to increase c-Fos expression; to a lesser extent, medium aspiny interneurons and glial cells also respond. In contrast, negligible change in c-Fos expression is observed in large neurons. These results are consistent with other evidence that medium-sized spiny neurons are preferentially vulnerable to the toxic effects of excitatory amino acids acting at N-methyl-D-aspartate receptors. An additional implication of these findings is that activation of the N-methyl-D-aspartate receptor in medium spiny neurons leads to increased expression of candidate AP-1 transcription factors, thereby coupling the N-methyl-D-aspartate receptor and regulation of gene expression in signal transduction processes of the neostriatal medium spiny neuron. C1 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL,SAN FRANCISCO,CA 94143. VET ADM MED CTR,SAN FRANCISCO,CA 94121. MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP ARONIN, N (reprint author), UNIV MASSACHUSETTS,SCH MED,DEPT MED,55 LAKE AVE,WORCESTER,MA 01655, USA. FU NINDS NIH HHS [NS 24666, NS 16367] NR 65 TC 92 Z9 92 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PY 1991 VL 44 IS 2 BP 409 EP 420 DI 10.1016/0306-4522(91)90065-V PG 12 WC Neurosciences SC Neurosciences & Neurology GA GC929 UT WOS:A1991GC92900013 PM 1834961 ER PT J AU BENES, FM FAROL, PA MAJOCHA, RE MAROTTA, CA BIRD, ED AF BENES, FM FAROL, PA MAJOCHA, RE MAROTTA, CA BIRD, ED TI EVIDENCE FOR AXONAL LOSS IN REGIONS OCCUPIED BY SENILE PLAQUES IN ALZHEIMER CORTEX SO NEUROSCIENCE LA English DT Article ID FIBROUS ASTROCYTES; DEMENTIA; DISEASE; PROTEIN; BRAIN AB The studies described have sought to determine what, if any, relationship exists between axons and the senile plaque, a hallmark histopathological feature of Alzheimer's disease. A double stain was performed on both early and late Alzheimer frontal cortex tissues in order to examine the interaction between axons stained with antibodies against the 200,000 mol. wt neurofilament subunit (NFP-200) of the axon cytoskeleton and Thioflavin-S, a fluorescent dye that stains plaques. Serial photomicrographs of plaques were taken and axon and plaque profiles were three-dimensionally reconstructed. Analysis of computer-processed images revealed that there were fewer axons within plaques than in regions lying one and two plaque distances away. When axons were observed passing through plaques, swelling and disruption of normal morphology was frequently present. Statistical analyses of axon counts within and around placques showed a gradient of axon density, with increased numbers occurring at progressive distances from the placque. Similar patterns were seen for early and late stages of the disease. The results of this study indicate that disruption of the axonal cytoskeleton may occur within the regions occupied by plaques. C1 HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,PROGRAM NEUROSCI,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,NEUROBIOL LABS,BOSTON,MA 02114. FU NIA NIH HHS [AG02126]; NIMH NIH HHS [MH/NS31862, MH00423] NR 21 TC 28 Z9 28 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PY 1991 VL 42 IS 3 BP 651 EP 660 DI 10.1016/0306-4522(91)90034-L PG 10 WC Neurosciences SC Neurosciences & Neurology GA FT330 UT WOS:A1991FT33000004 PM 1956514 ER PT J AU QUIGLEY, BJ KOWALL, NW AF QUIGLEY, BJ KOWALL, NW TI SUBSTANCE-P-LIKE IMMUNOREACTIVE NEURONS ARE DEPLETED IN ALZHEIMERS-DISEASE CEREBRAL-CORTEX SO NEUROSCIENCE LA English DT Article ID SOMATOSTATIN-LIKE IMMUNOREACTIVITY; CORTICOTROPIN-RELEASING FACTOR; CENTRAL NERVOUS-SYSTEM; NEUROPEPTIDE-Y; SENILE DEMENTIA; HIPPOCAMPAL-FORMATION; NEURITIC PLAQUES; RAT; NEOCORTEX; FIBERS AB We studied the morphology and distribution of substance P-like immunoreactive elements in normal and Alzheimer's disease brain with a monoclonal anti-substance P antibody. Bands of prominent terminal-like staining were found in the dentate gyrus of normal brain. Multipolar substance P-immunoreactive neurons were seen in dentate polymorphic layer and CA4 and prominent fiber staining was present in the CA fields of the hippocampus and adjacent allocortex. Reactive perikarya, concentrated in deep cortex and infracortical white matter, were found in all isocortical regions. Greatest density was in frontal and parietal association cortex; lowest in visual cortex. Fiber density was generally greatest in layers I and II. In Alzheimer's disease, staining intensity was reduced in the dentate gyrus. Hilar neurons were unaffected but other CA field neurons were distorted with pruned dendritic trees. Isocortical perikarya and fibers were significantly depleted and distorted in all regions. Globular deposits consisting of distorted neurites or dissolving perikarya were frequently seen. Double staining methods showed that the vast majority of isocortical, but not hippocampal, substance P-like immunoreactive neurons are nicotinamide adenine dinucleotide phosphate diaphorase-positive. Despite the modest quantitative depletion of substance P in Alzheimer's disease cortex as measured by radioimmunoassay compared to somatostatin, there is a significant depletion of substance P-like immunoreactive perikarya. This disparity may be due to persistence of afferent projections which make a major contribution to substance P concentrations in cerebral cortex or to the high substance P content of dystrophic fibers in Alzheimer's disease cortex. C1 MASSACHUSETTS GEN HOSP,NEUROL SERV,BOSTON,MA 02114. RI Kowall, Neil/G-6364-2012 OI Kowall, Neil/0000-0002-6624-0213 FU NIA NIH HHS [AG 05134]; NINDS NIH HHS [NS 25588] NR 39 TC 53 Z9 53 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PY 1991 VL 41 IS 1 BP 41 EP 60 DI 10.1016/0306-4522(91)90199-X PG 20 WC Neurosciences SC Neurosciences & Neurology GA FH564 UT WOS:A1991FH56400004 PM 1711654 ER PT J AU SANGRUCHI, T KOWALL, NW AF SANGRUCHI, T KOWALL, NW TI NADPH DIAPHORASE HISTOCHEMISTRY OF THE HUMAN HYPOTHALAMUS SO NEUROSCIENCE LA English DT Article ID CENTRAL NERVOUS-SYSTEM; DINUCLEOTIDE PHOSPHATE-DIAPHORASE; NEUROPEPTIDE-Y; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; CONTAINING NEURONS; HUMAN-BRAIN; RAT; SOMATOSTATIN; STRIATUM AB The morphology and distribution of NADPH diaphorase reactive neurons was studied in the normal human hypothalamus. Reactive neurons were divided into three categories on the basis of perikaryal size. Small neurons (8-20-mu-m) were oval or fusiform, and pale staining. Intermediate neurons (20-30-mu-m) were fusiform, triangular or pyramidal with a wide range of staining intensity. Large neurons (> 30-mu-m) were triangular or pyramidal with moderate to dark staining. Reactive neurons were found in four major regions: medial preoptic, ventromedial, lateral, and perifornical. Scattered positive neurons were found in several other hypothalamic areas. Reactive fibers were present in the supraoptic decussation, medial forebrain bundle, and stria medullaris thalami. The localization of NADPH diaphorase neurons in hypothalamic nuclei affected by Alzheimer's disease and other degenerative disorders suggests that further studies of this neuronal subset are warranted. C1 MASSACHUSETTS GEN HOSP,DEPT NEUROPATHOL,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,NEUROL SERV,BOSTON,MA 02114. RI Kowall, Neil/G-6364-2012 OI Kowall, Neil/0000-0002-6624-0213 FU NIA NIH HHS [AG05134]; NINDS NIH HHS [NS25588] NR 36 TC 17 Z9 17 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4522 J9 NEUROSCIENCE JI Neuroscience PY 1991 VL 40 IS 3 BP 713 EP 724 DI 10.1016/0306-4522(91)90007-B PG 12 WC Neurosciences SC Neurosciences & Neurology GA FJ729 UT WOS:A1991FJ72900007 PM 2062439 ER PT J AU ANSON, JA STONE, JL CROWELL, RM AF ANSON, JA STONE, JL CROWELL, RM TI RUPTURE OF A GIANT CAROTID ANEURYSM AFTER EXTRACRANIAL-TO-INTRACRANIAL BYPASS-SURGERY SO NEUROSURGERY LA English DT Article DE CAROTID OCCLUSION; EXTRACRANIAL-INTRACRANIAL ANASTOMOSIS; GIANT ANEURYSM; SUBARACHNOID HEMORRHAGE ID MIDDLE CEREBRAL-ARTERY; OCCLUSION; ANASTOMOSIS; LIGATION; REVASCULARIZATION; COMPLICATIONS; GRAFT AB We report a case of a fatal rupture of a previously unruptured giant aneurysm of the bifurcation of the internal carotid artery (ICA), which occurred after an extracranial-intracranial (EC-IC) bypass and the partial occlusion of the ICA. Interim angiography showed retrograde filling of the proximal middle cerebral artery to the aneurysm. There have been four previously reported cases of giant aneurysms rupturing after treatment with an EC-IC bypass and carotid ligation, and it appears likely that a change in pressure/flow dynamics produced by the bypass may have been the cause. The technique of carotid ligation with an EC-IC bypass is used frequently to treat unclippable intracranial aneurysms, and the resulting hemodynamic changes need to be considered carefully to prevent this type of complication. To minimize hemodynamic stress on the aneurysm, we suggest that 1) the bypass caliber should be as small as possible consistent with sufficient cerebral blood flow after ICA occlusion, and 2) complete ICA occlusion should be performed as soon as possible after the bypass. C1 COOK CTY HOSP,DIV NEUROSURG,CHICAGO,IL 60612. MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114. RP ANSON, JA (reprint author), UNIV ILLINOIS HOSP,DEPT NEUROSURG,ROOM 671N,912 S WOOD ST,M-C 799,CHICAGO,IL 60612, USA. NR 24 TC 21 Z9 21 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD JAN PY 1991 VL 28 IS 1 BP 142 EP 147 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA EP137 UT WOS:A1991EP13700020 PM 1994269 ER PT J AU STRAUSS, HW FISCHMAN, AJ KHAW, BA RUBIN, RH AF STRAUSS, HW FISCHMAN, AJ KHAW, BA RUBIN, RH TI NONTUMOR APPLICATIONS OF RADIOIMMUNE IMAGING SO NUCLEAR MEDICINE AND BIOLOGY LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL CONF ON DIAGNOSIS AND THERAPY WITH MONOCLONAL ANTIBODIES CY APR 26-28, 1990 CL NAPLES, ITALY ID MONOCLONAL ANTIMYOSIN ANTIBODY; MYOSIN-SPECIFIC ANTIBODY; INFECTION; FAB AB The application of radioimmune imaging techniques to the evaluation of non-neoplastic disease is largely based on the same principles as tumor imaging; specificity and high affinity of antibodies. Currently the most common non-tumor applications of antibody imaging are the detection of clots (peripheral and pulmonary emboli), myocardial necrosis (myocardial infarction, myocarditis and cardiac transplant rejection) and focal sites of infection/inflammation. In the area of injection imaging, both antigen-specific and non-specific properties of antibodies have been successfully exploited in imaging studies. While the number of non-tumor application of antibodies are far fewer than the number of tumor studies, in many cases, they appear to be more reliable. The basis for the reliability of antibodies for detecting non-neoplastic lesions is probably related to the availability of abundant antigen, lack of antigen modulation and enhanced permeability at the lesion site. These observations suggest that there will be rapid proliferation of work in this area. RP STRAUSS, HW (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,DIV NUCL MED,BOSTON,MA 02114, USA. NR 25 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0883-2897 J9 NUCL MED BIOL JI Nucl. Med. Biol. PY 1991 VL 18 IS 1 BP 127 EP & PG 0 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EW695 UT WOS:A1991EW69500022 ER PT J AU CHAUDHURI, TK AF CHAUDHURI, TK TI RADIONUCLIDE METHODS OF DETECTING ACUTE GASTROINTESTINAL-BLEEDING SO NUCLEAR MEDICINE AND BIOLOGY LA English DT Article; Proceedings Paper CT SYMP AT THE 1989 ANNUAL CONF OF THE SOC OF NUCLEAR MEDICINE, INDIA : CURRENT TRENDS AND FUTURE PERSPECTIVES IN NUCLEAR MEDICINE CY DEC 17-20, 1989 CL LUCKNOW, INDIA SP INDO AMER SOC NUCL MED, SOC NUCL MED INDIA ID RED-BLOOD-CELLS AB It is clinically very important to localize the bleeding site in suspected patients. Current common diagnostic methods are endoscopic, angiographic, and radionuclidic. Of the noninvasive procedures, Tc-99m-RBC and Tc-99m-colloid methods have gained wide popularity. In our series of a comparative study, the RBC method has been shown to be more accurate than the colloid method. The Tc-99m-RBC method should be available as a routine emergency procedure in every large clinical center. C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. RP CHAUDHURI, TK (reprint author), AUDIE L MURPHY MEM VET ADM MED CTR,NUCL MED SERV,SAN ANTONIO,TX 78284, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0883-2897 J9 NUCL MED BIOL JI Nucl. Med. Biol. PY 1991 VL 18 IS 6 BP 655 EP 661 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GB121 UT WOS:A1991GB12100011 ER PT J AU YIN, O NARULA, J NOSSIFF, N KHAW, BA AF YIN, O NARULA, J NOSSIFF, N KHAW, BA TI CORRELATION OF IMMUNOREACTIVITY AND POLYMER FORMATION TO DTPA MODIFICATION OF A MONOCLONAL-ANTIBODY SO NUCLEAR MEDICINE AND BIOLOGY LA English DT Article ID ANTIMYOSIN FAB AB The protocol used for coupling of monoclonal antibodies with mixed anhydride of DTPA for subsequent radiolabeling with indium-111 affects the integrity of the immunoreactivity of the antibody preparations. To analyze the effect of minor methodological variations on coupling characteristics, a two-step addition of DTPA to antimyosin antibody with gentle mixing was compared to a single addition with vigorous stirring. The molar ratios of DTPA to antibody were also varied. The polymer formation was assessed by SDS-PAGE and immunoreactivity was assessed by solid phase radioimmunoassay using human heart myosin as the antigen. The immunoreactivity was significantly decreased in the two-step, gentle-mixing method where polymer formation was evident. The one-step, vigorous-stirring method of DTPA incorporation produced no polymerization and no loss of immunoreactivity. C1 MASSACHUSETTS GEN HOSP,DIV NUCL MED,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,CARDIAC UNIT,BOSTON,MA 02114. NR 18 TC 3 Z9 3 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0883-2897 J9 NUCL MED BIOL JI Nucl. Med. Biol. PY 1991 VL 18 IS 8 BP 859 EP & PG 0 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GP782 UT WOS:A1991GP78200005 ER PT J AU ROSOWSKY, A PAI, NN AF ROSOWSKY, A PAI, NN TI SYNTHESIS OF THE 2',3'-DIDEHYDRO-2',3'-DIDEOXY AND 2',3'-DIDEOXY DERIVATIVES OF 6-AZAURIDINE AND A NEW ROUTE TO 2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-CHLOROURIDINE SO NUCLEOSIDES & NUCLEOTIDES LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; ANTI-HIV; ANTIVIRAL ACTIVITY; HTLV-III/LAV; INVITRO; ANALOGS; INHIBITION; REPLICATION; PYRIMIDINE; POTENT AB The 5'-O-(4,4'-dimethoxytrityl) and 5'-O-(tert-butyldimethylsilyl) derivatives of 2',3'-O-thiocarbonyl-6-azauridine and 2',3'-O-thiocarbonyl-5-chlorouridine were synthesized from the parent nucleosides by reaction with 4,4'-dimethoxytrityl chloride and tert-butyldimethylsilyl chloride, respectively, followed by treatment with 1,1'-thiocarbonyldiimidazole. Introduction of a 2', 3'-double bond into the sugar ring by reaction of the 5'-protected 2', 3'-O-thionocarbonates with 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine was unsuccessful, but could be accomplished satisfactorily with trimethyl phosphite. Reactions were generally more successful with the 5'-silylated than with the 5'-tritylated nucleosides. Formation of 2',3'-O-thiocarbonyl derivatives proceeded in higher yield with 5'-protected 6-azauridines than with the corresponding 5-chlorouridines because of the propensity of the latter to form 2,2'-anhydro derivatives. In the reaction of 5'-O-(tert-butyl-dimethylsilyl)-2',3'-O-thiocarbonyl-6-azauridine with trimethyl phosphite, introduction of the double bond was accompanied by N3-methylation. However this side reaction was not a problem with 5'-O-(tert-butyldimethylsilyl)-2',3'-O-thiocarbonyl-5-chlorouridine. Treatment of 5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxy-6-azauridine with tetrabutylammonium fluoride followed by hydrogenation afforded 2',3'-dideoxy-6-azauridine. Deprotection of 5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxy-5-chlorouridine yielded 2',3'-didehydro-2',3'-dideoxy-5-chlorouridine. C1 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. RP ROSOWSKY, A (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115, USA. NR 35 TC 1 Z9 1 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0732-8311 J9 NUCLEOS NUCLEOT JI Nucleosides Nucleotides PY 1991 VL 10 IS 4 BP 837 EP 851 DI 10.1080/07328319108046665 PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FU949 UT WOS:A1991FU94900007 ER PT J AU SAHA, J RUPRECHT, RM ROSOWSKY, A AF SAHA, J RUPRECHT, RM ROSOWSKY, A TI PHOSPHONOFORMATE ESTERS OF ANTI-HIV NUCLEOSIDES - 3'-AZIDO-3'-DEOXYTHYMIDINE AND 2',3'-DIDEOXYCYTIDINE DERIVATIVES CONTAINING A SMALL 5'-(O-ALKOXYCARBONYLPHOSPHINYL) OR 5'-(O-CHOLESTERYLCARBONYLPHOSPHINYL) SUBSTITUENT SO NUCLEOSIDES & NUCLEOTIDES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; AIDS-RELATED COMPLEX; REVERSE-TRANSCRIPTASE; ANTIVIRAL ACTIVITY; REPLICATION; FOSCARNET; ANALOGS; AZIDOTHYMIDINE; COMBINATIONS; ZIDOVUDINE AB A convenient general method of synthesis of 5'-O-(alkoxycarbonyl)phosphonate esters of 2',3'-dideoxyribonucleosides is presented, using the 5'-O-(methoxycarbonyl)phosphinyl, 5'-O-(ethoxycarbonyl)phosphinyl, and 5'-O-(cholesterylcarbonyl)phosphinyl derivatives of 3'-azido-3'-deoxythymidine (AZT) and the 5'-O-(ethoxycarbonyl)phosphinyl derivative of 2',3'-dideoxycytidine (ddC) as examples. Reaction of trimethyl phosphonoformate, triethyl phosphonoformate, or dimethyl cholesterylcarbonylphosphonate with phosphorus pentachloride in carbon tetrachloride, followed by direct condensation of the resulting phosphonyl chloride with the nucleoside, gave the fully esterified phosphonoformate derivatives, which on treatment with sodium iodide in tetrahydrofuran underwent selective cleavage of the P-OMe or P-OEt groups, leaving the carboxylate esters intact. The resulting products were converted from sodium salts to ammonium salts by ion-exchange chromatography. C1 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. NR 26 TC 6 Z9 6 U1 0 U2 2 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0732-8311 J9 NUCLEOS NUCLEOT JI Nucleosides Nucleotides PY 1991 VL 10 IS 7 BP 1465 EP 1475 DI 10.1080/07328319108046675 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GK534 UT WOS:A1991GK53400003 ER PT J AU WEISMAN, AD AF WEISMAN, AD TI BEREAVEMENT AND COMPANION ANIMALS SO OMEGA-JOURNAL OF DEATH AND DYING LA English DT Article RP WEISMAN, AD (reprint author), MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,16 BLOSSOM ST,BOSTON,MA 02114, USA. NR 5 TC 17 Z9 17 U1 0 U2 0 PU BAYWOOD PUBL CO INC PI AMITYVILLE PA 26 AUSTIN AVE, AMITYVILLE, NY 11701 SN 0030-2228 J9 OMEGA-J DEATH DYING JI Omega-J. Death Dying PY 1991 VL 22 IS 4 BP 241 EP 248 PG 8 WC Psychology, Multidisciplinary; Social Sciences, Biomedical SC Psychology; Biomedical Social Sciences GA FK257 UT WOS:A1991FK25700001 ER PT J AU SPRINGFIELD, DS AF SPRINGFIELD, DS TI INTRODUCTION TO LIMB-SALVAGE SURGERY FOR SARCOMAS SO ORTHOPEDIC CLINICS OF NORTH AMERICA LA English DT Article ID SOFT-TISSUE SARCOMAS; OSTEOGENIC-SARCOMA C1 HARVARD UNIV,SCH MED,ORTHOPED SURG,BOSTON,MA 02115. RP SPRINGFIELD, DS (reprint author), MASSACHUSETTS GEN HOSP,GRAY 6,BOSTON,MA 02114, USA. NR 8 TC 13 Z9 14 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0030-5898 J9 ORTHOP CLIN N AM JI Orthop. Clin. North Am. PD JAN PY 1991 VL 22 IS 1 BP 1 EP 5 PG 5 WC Orthopedics SC Orthopedics GA EW951 UT WOS:A1991EW95100002 PM 1992427 ER PT J AU CHENG, EY GEBHARDT, MC AF CHENG, EY GEBHARDT, MC TI ALLOGRAFT RECONSTRUCTIONS OF THE SHOULDER AFTER BONE-TUMOR RESECTIONS SO ORTHOPEDIC CLINICS OF NORTH AMERICA LA English DT Article ID OSTEOGENIC-SARCOMA; PROXIMAL HUMERUS; LIMB SALVAGE; REPLACEMENT; TRANSPLANTATION; CHEMOTHERAPY; RESTORATION; MANAGEMENT; EXCISION C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,CHILDRENS HOSP,MED SCH,MED CTR,DEPT ORTHOPAED,32 FRUIT ST,BOSTON,MA 02114. UNIV MINNESOTA HOSP & CLIN,ORTHOPAED SURG,MINNEAPOLIS,MN 55455. NR 52 TC 26 Z9 27 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0030-5898 J9 ORTHOP CLIN N AM JI Orthop. Clin. North Am. PD JAN PY 1991 VL 22 IS 1 BP 37 EP 48 PG 12 WC Orthopedics SC Orthopedics GA EW951 UT WOS:A1991EW95100004 PM 1992433 ER PT J AU JOHNSON, ME MANKIN, HJ AF JOHNSON, ME MANKIN, HJ TI RECONSTRUCTIONS AFTER RESECTIONS OF TUMORS INVOLVING THE PROXIMAL FEMUR SO ORTHOPEDIC CLINICS OF NORTH AMERICA LA English DT Article ID BONE-GRAFTS; OSTEOGENIC-SARCOMA; HIP; REPLACEMENT; EXTREMITY; PROSTHESES; MANAGEMENT; ALLOGRAFTS; DEFECTS; SALVAGE C1 KAISER PERMANENTE MED CTR,SAN FRANCISCO,CA. MASSACHUSETTS GEN HOSP,ORTHOPAED SURG,BOSTON,MA 02114. NR 54 TC 30 Z9 31 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0030-5898 J9 ORTHOP CLIN N AM JI Orthop. Clin. North Am. PD JAN PY 1991 VL 22 IS 1 BP 87 EP 103 PG 17 WC Orthopedics SC Orthopedics GA EW951 UT WOS:A1991EW95100007 PM 1992437 ER PT J AU SPRINGFIELD, DS AF SPRINGFIELD, DS TI LIMB SALVAGE IN THE TREATMENT OF MUSCULOSKELETAL TUMORS - PREFACE SO ORTHOPEDIC CLINICS OF NORTH AMERICA LA English DT Article RP SPRINGFIELD, DS (reprint author), MASSACHUSETTS GEN HOSP,GRAY 6,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0030-5898 J9 ORTHOP CLIN N AM JI Orthop. Clin. North Am. PD JAN PY 1991 VL 22 IS 1 BP R9 EP R9 PG 1 WC Orthopedics SC Orthopedics GA EW951 UT WOS:A1991EW95100001 ER PT J AU FERRY, JA YOUNG, RH AF FERRY, JA YOUNG, RH TI MALIGNANT-LYMPHOMA, PSEUDOLYMPHOMA, AND HEMATOPOIETIC DISORDERS OF THE FEMALE GENITAL-TRACT SO PATHOLOGY ANNUAL LA English DT Review ID RETICULUM-CELL SARCOMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; GRANULOCYTIC SARCOMA; UTERINE CERVIX; PRIMARY MANIFESTATION; OVARIAN TUMOR; CYTOLOGIC DIAGNOSIS; BURKITTS-LYMPHOMA; HODGKINS-DISEASE; UTERUS C1 MASSACHUSETTS GEN HOSP,JAMES HOMER WRIGHT PATHOL LABS,BOSTON,MA 02114. RP FERRY, JA (reprint author), HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115, USA. NR 124 TC 47 Z9 48 U1 0 U2 1 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0079-0184 J9 PATHOL ANNU JI Pathol. Annu. PY 1991 VL 26 BP 227 EP 263 PN 1 PG 37 WC Pathology SC Pathology GA EN469 UT WOS:A1991EN46900009 PM 2014141 ER PT J AU HARAWI, SJ GHOSSEIN, RA KURBAN, RS KURBAN, AK AF HARAWI, SJ GHOSSEIN, RA KURBAN, RS KURBAN, AK TI CUTANEOUS DISEASES ASSOCIATED WITH HIV-INFECTION SO PATHOLOGY ANNUAL LA English DT Review ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; AIDS-RELATED COMPLEX; IMMUNE-DEFICIENCY SYNDROME; EOSINOPHILIC PUSTULAR FOLLICULITIS; EPIDERMAL LANGERHANS CELLS; INDUCED NAIL PIGMENTATION; CYTO-TOXIC LYMPHOCYTES; HTLV-III/LAV INFECTION; HIGH-RISK INDIVIDUALS; ACID-FAST BACILLI C1 BOSTON UNIV,SCH MED,MALLORY INST PATHOL,BOSTON,MA 02118. NEW ENGLAND MED CTR HOSP,BOSTON,MA 02111. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. BOSTON UNIV,SCH MED,DEPT DERMATOL,BOSTON,MA 02118. RP HARAWI, SJ (reprint author), HACKENSACK MED CTR,HACKENSACK,NJ 07601, USA. NR 211 TC 4 Z9 4 U1 1 U2 1 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0079-0184 J9 PATHOL ANNU JI Pathol. Annu. PY 1991 VL 26 BP 265 EP 309 PN 1 PG 45 WC Pathology SC Pathology GA EN469 UT WOS:A1991EN46900010 PM 2014143 ER PT J AU HIBBERD, PL RUBIN, RH AF HIBBERD, PL RUBIN, RH TI PREVENTION OF CYTOMEGALOVIRUS-INFECTION IN THE PEDIATRIC RENAL-TRANSPLANT RECIPIENT SO PEDIATRIC NEPHROLOGY LA English DT Review DE CYTOMEGALOVIRUS; RENAL TRANSPLANT; CYTOTOXIC AGENTS; HYPERIMMUNE GLOBULIN; ANTIVIRAL CHEMOTHERAPY; VACCINATION AB Cytomegalovirus (CMV) infection is the most important single infectious complication of organ transplantation, affecting more than 70% of transplant recipients. Its emergence as a major pathogen has coincided with the use of cytotoxic therapy. Manifestations of serious CMV disease include: pneumonia, hepatitis, gastrointestinal disease, leukopenia and chorioretinitis. CMV is associated with superinfection with opportunistic organisms, graft failure and increased mortality. Serious infection most frequently occurs with primary CMV infection in which latently infected cells from CMV-positive donors are given to seronegative recipients. Pediatric patients who have a lower pre-transplant rate of CMV seropositivity are at particularly high risk of developing serious CMV disease. Preventative efforts range from the ideal but impractical use of only CMV-negative donors (organ and blood products), to the use of CMV hyperimmune globulin and antiviral chemotherapy. Data support the use of prophylactic hyperimmune globulin and preliminary information supports the use of prophylactic high-dose acyclovir in renal transplant patients. Prophylactic gancyclovir alone or with hyperimmune globulin and pre-transplant vaccination with live-attenuated Towne strain CMV vaccine remain investigational. C1 MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,BOSTON,MA 02114. FU NHLBI NIH HHS [HL 18646] NR 0 TC 12 Z9 12 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0931-041X J9 PEDIATR NEPHROL JI Pediatr. Nephrol. PY 1991 VL 5 IS 1 BP 112 EP 117 PG 6 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA EV921 UT WOS:A1991EV92100030 PM 1851031 ER PT J AU ZUPANC, ML DOBKIN, JA PERLMAN, SB AF ZUPANC, ML DOBKIN, JA PERLMAN, SB TI I-123 IODOAMPHETAMINE SPECT BRAIN IMAGING IN ALTERNATING HEMIPLEGIA SO PEDIATRIC NEUROLOGY LA English DT Article ID COMPLICATED MIGRAINE; CHILDHOOD; FLUNARIZINE; CHILDREN; INFANCY AB Alternating hemiplegia of childhood is an unusual disorder characterized by early onset (occurring before 18 months of age); repeated attacks of hemiplegia involving both sides of the body; other paroxysmal phenomena, such as tonic stiffening, dystonic posturing, choreoathetoid movements, ocular motor abnormalities, and autonomic disturbances, in association with bouts of hemiplegia or occurring independently; and evidence of mental or neurologic deficits. A girl was examined because of left hemiplegia at the age of 16 months. The patient had begun exhibiting episodes of alternating hemiplegia at approximately 4 months of age. They consisted of tonic stiffening and dystonia of the right or left extremities, lasting from 30 min to several hours and followed by residual hemiparesis. They were invariably accompanied by ocular motor abnormalities. Magnetic resonance imaging, computed tomography, and angiography all were normal. Single proton emission computed tomography brain images during an acute episode of right hemiplegia demonstrated hypoperfusion of the left cerebral hemisphere. Following improvement of the hemiplegia, the patient was re-evaluated. The uptake of the radiotracer in the left hemisphere was increased. The scan did not demonstrate significant asymmetry in cerebral perfusion. C1 UNIV WISCONSIN HOSP & CLIN,DEPT NUCL MED,MADISON,WI. UNIV WISCONSIN HOSP,DEPT NEUROL,MADISON,WI 53792. WILLIAM S MIDDLETON MEM VET ADM MED CTR,MADISON,WI 53705. NR 9 TC 31 Z9 32 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0887-8994 J9 PEDIATR NEUROL JI Pediatr. Neurol. PD JAN-FEB PY 1991 VL 7 IS 1 BP 35 EP 38 DI 10.1016/0887-8994(91)90103-R PG 4 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA EY978 UT WOS:A1991EY97800006 PM 1903036 ER PT J AU FRIM, DM JONES, D GOUMNEROVA, L AF FRIM, DM JONES, D GOUMNEROVA, L TI DEVELOPMENT OF SYMPTOMATIC CHIARI MALFORMATION IN A CHILD WITH CRANIOFACIAL DYSMORPHISM SO PEDIATRIC NEUROSURGERY LA English DT Article DE CHIARI MALFORMATION; CRANIOFACIAL DYSMORPHISM ID VOCAL CORD PARALYSIS AB We present the case of a 28-month-old child with craniofacial anomalies who presented for evaluation of apnea. The patient had associated symptoms referable to a Chiari malformation and MRI scanning of the head and cervical spine revealed some, but not all, of the anatomical features classically associated with the Chiari II malformation. The child has mid-face hypoplasia and it appeared that his posterior fossa hypertension was partially caused by anterior compression of the brain stem as a result of the malformation at the base of the skull. The patient responded dramatically to posterior fossa decompression. Evidence from this and other cases from the literature suggests that different pathophysiological mechanisms may cause the classic Chiari malformation and/or other anatomical abnormalities in the continuum between Chiari I and II. C1 HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT NEUROSURG,300 LONGWOOD AVE,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114. HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT ORL,BOSTON,MA 02115. NR 15 TC 4 Z9 4 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1016-2291 J9 PEDIATR NEUROSURG JI Pediatr. Neurosurg. PY 1991 VL 16 IS 4-5 BP 228 EP 231 PG 4 WC Clinical Neurology; Pediatrics; Surgery SC Neurosciences & Neurology; Pediatrics; Surgery GA HE147 UT WOS:A1991HE14700009 ER PT J AU SNYDER, JD AF SNYDER, JD TI USE AND MISUSE OF ORAL-THERAPY FOR DIARRHEA - COMPARISON OF UNITED-STATES PRACTICES WITH AMERICAN-ACADEMY-OF-PEDIATRICS RECOMMENDATIONS SO PEDIATRICS LA English DT Article DE ORAL THERAPY; DIARRHEAL DISEASE ID GLUCOSE-ELECTROLYTE SOLUTION; REHYDRATION THERAPY; CHILDREN; CHOLERA AB To determine how closely US pediatricians follow the 1985 American Academy of Pediatrics Committee on Nutrition's recommendations on oral therapy for acute diarrhea, a questionnaire was administered to four groups: New England private practitioners, pediatrics from 27 states attending a postgraduate course, representatives of department of pediatrics as US schools of medicine, and housestaff at Boston Children's and Massachusetts General hospitals. The responses from departments of pediatrics and housestaff were not significantly different from those of community practitioners in most categories. The reported rate of use of glucose-electrolyte solutions recommended by the American Academy of Pediatrics was not different from the use of nonphysiologic, high-osmolar, low-salt solutions such as sodas and juices. The usage rate for glucose-electrolyte solutions meeting the American Academy of Pediatrics-recommended carbohydrate-to-sodium ratio of less that 2:1 was less than 30%. Other finding included the general lack of agreement on the use of a single type of therapy and the common use of oral therapy only for mild of no dehydration. Although the American Academy of Pediatrics recommends that feeding be reintroduced in the first 24 hours of a diarrhea episode, the majority or respondents withhold feeding until the second day or later. These findings indicate that educational programs on oral therapy during acute diarrhea are needed in the United State. C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. RP SNYDER, JD (reprint author), CHILDRENS HOSP MED CTR,COMBINED PROGRAM PEDIAT GASTROENTEROL & NUTR,HU-002,BOSTON,MA 02115, USA. NR 33 TC 63 Z9 64 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JAN PY 1991 VL 87 IS 1 BP 28 EP 33 PG 6 WC Pediatrics SC Pediatrics GA EQ978 UT WOS:A1991EQ97800004 PM 1984614 ER PT J AU DUNN, DA LIN, VH KOCHEVAR, IE AF DUNN, DA LIN, VH KOCHEVAR, IE TI THE ROLE OF GROUND-STATE COMPLEXATION IN THE ELECTRON-TRANSFER QUENCHING OF METHYLENE-BLUE FLUORESCENCE BY PURINE NUCLEOTIDES SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Article ID NUCLEIC-ACIDS; PHOTODYNAMIC DAMAGE; REDOX PROCESSES; DEOXYRIBONUCLEIC-ACID; COBALT BLEOMYCIN; DNA; CLEAVAGE; PHOTOSENSITIZATION; POLYNUCLEOTIDES; SPECTROSCOPY AB The effect of three purine nucleotides on the fluorescence of methylene blue in aqueous buffer has been investigated. Guanosine-5'-monophosphate (GMP) and xanthosine-5'-monophosphate cause fluorescence quenching while adenosine-5'-monophosphate causes a red shift in the fluorescence maximum. All three nucleotides form ground state complexes with the nucleotides as indicated by absorption spectroscopy. The fluorescence changes at nucleotide concentrations < 30 mM are best described by a static mechanism involving the formation of non-fluorescent binary and ternary complexes in competition with dimerization of the dye. Quenching of the fluorescence decay (tau = 368 ps) at high GMP concentrations (10-100 mM) occurs at the rate of diffusion. The mechanism of fluorescence quenching may involve electron transfer within the singlet excited dye-nucleotide complex although published values of the oxidation potentials of various purine derivatives would suggest that all three nucleotides should cause quenching. Evidence for electron transfer was obtained from flash photolysis experiments in which 100 mM GMP was found to cause the appearance of a long lived transient species absorbing in the region expected for semimethylene blue. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT DERMATOL,WELLMAN LABS,BOSTON,MA 02114. NR 53 TC 42 Z9 42 U1 1 U2 9 PU AMER SOC PHOTOBIOLOGY PI AUGUSTA PA BIOTECH PARK, 1021 15TH ST, SUITE 9, AUGUSTA, GA 30901-3158 SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD JAN PY 1991 VL 53 IS 1 BP 47 EP 56 DI 10.1111/j.1751-1097.1991.tb08466.x PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EQ438 UT WOS:A1991EQ43800007 PM 2027906 ER PT J AU DONG, XN MINDRINOS, M DAVIS, KR AUSUBEL, FM AF DONG, XN MINDRINOS, M DAVIS, KR AUSUBEL, FM TI INDUCTION OF ARABIDOPSIS DEFENSE GENES BY VIRULENT AND AVIRULENT PSEUDOMONAS-SYRINGAE STRAINS AND BY A CLONED AVIRULENCE GENE SO PLANT CELL LA English DT Article ID PHENYLALANINE AMMONIA-LYASE; POLYMORPHISM LINKAGE MAP; CHALCONE SYNTHASE; MESSENGER-RNA; ANTIFUNGAL HYDROLASES; FUNGAL INFECTION; PV GLYCINEA; PEA TISSUE; THALIANA; RESISTANCE AB We developed a model system to study the signal transduction pathways leading to the activation of Arabidopsis thaliana genes involved in the defense against pathogen attack. Here we describe the identification and characterization of virulent and avirulent Pseudomonas syringae strains that elicit disease or resistance symptoms when infiltrated into Arabidopsis leaves. The virulent and avirulent strains were characterized by determining growth of the pathogen in Arabidopsis leaves and by measuring accumulation of mRNA corresponding to Arabidopsis phenylalanine ammonia-lyase (PAL), beta-1,3-glucanase (BG), and chalcone synthase (CHS) genes in infected leaves. The virulent strain, P. syringae pv maculicola ES4326, multiplied 10(5)-fold in Arabidopsis leaves and strongly elicited BG1, BG2, and BG3 mRNA accumulation but had only a modest effect on PAL mRNA accumulation. In contrast, the avirulent strain, P. syringae pv tomato MM1065, multiplied less than 10-fold in leaves and had only a minimal effect on BG1, BG2, and BG3 mRNA accumulation, but it induced PAL mRNA accumulation. No accumulation of CHS mRNA was found with either ES4326 or MM1065. We also describe the cloning of a putative avirulence (avr) gene from the avirulent strain MM1065 that caused the virulent strain ES4326 to grow less well in leaves and to strongly elicit PAL but not BG1 and BG3 mRNA accumulation. These results suggest that the Arabidopsis PAL and BG genes may be activated by distinct signal transduction pathways and show that differences in plant gene induction by virulent and avirulent strains can be attributed to a cloned presumptive avr gene. C1 HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. OHIO STATE UNIV,DEPT PLANT BIOL,COLUMBUS,OH 43210. OHIO STATE UNIV,CTR BIOTECHNOL,COLUMBUS,OH 43210. RI Davis, Keith/C-5623-2009 OI Davis, Keith/0000-0002-7432-8610 NR 54 TC 273 Z9 287 U1 4 U2 10 PU AMER SOC PLANT PHYSIOLOGISTS PI ROCKVILLE PA 15501 MONONA DRIVE, ROCKVILLE, MD 20855 SN 1040-4651 J9 PLANT CELL JI Plant Cell PD JAN PY 1991 VL 3 IS 1 BP 61 EP 72 DI 10.1105/tpc.3.1.61 PG 12 WC Biochemistry & Molecular Biology; Plant Sciences; Cell Biology SC Biochemistry & Molecular Biology; Plant Sciences; Cell Biology GA ET769 UT WOS:A1991ET76900006 PM 1824335 ER PT J AU PFITZNER, AJP BEILMANN, A GOODMAN, HM PFITZNER, UM AF PFITZNER, AJP BEILMANN, A GOODMAN, HM PFITZNER, UM TI MOLECULAR ANALYSIS OF 2 PR-1 PSEUDOGENES FROM TOBACCO SO PLANT MOLECULAR BIOLOGY LA English DT Article DE NICOTIANA-TABACUM CV WISCONSIN-38; PR-1 GENES; PSEUDOGENES; TRANSGENIC PLANTS ID PATHOGENESIS-RELATED PROTEINS; GENE-FUSION MARKER; CV XANTHI-NC; NICOTIANA-TABACUM; MOSAIC-VIRUS; NUCLEOTIDE-SEQUENCE; BETA-GLUCURONIDASE; TMV INFECTION; CDNA CLONES; PLANT-CELLS AB Two independent PR-l-lambda-genomic clones (W38/1 and W38/3) were isolated and characterized from a tobacco (Nicotiana tabacum cv. Wisconsin 38) library. Neither clone is identical to the previously described PR-1 cDNA clones, and both clones carry mutations within the highly conserved PR-1 protein coding region. For example, clone W38/1 has a GAA Glu codon instead of the translation stop codon thus harbouring an open reading frame extended by 16 additional amino acids. Furthermore, both clones display considerable variations in the genomic flanking sequences when compared to the PR-1a gene. In order to test whether the encoded genes are active, their upstream sequences were fused to the E. coli beta-glucuronidase (GUS) reporter gene. While significant GUS activities as compared to the 35S RNA promoter from cauliflower mosaic virus (CaMV) were obtained with the W38/1 and W38/3 sequences in transient gene expression assays, no transcriptional activities could be observed upon stable transformation of the same constructs. In addition, the protein coding region of W38/1 was joined to the CaMV 35S RNA promoter and transgenic tobacco plants were generated. However, neither transcripts nor a protein could be detected deriving from the W38/1 structural gene with this chimaeric construct in the transformants. Taken together, these data indicate that the genes contained in lambda-clones W38/1 and W38/3 are not active in planta. C1 LUDWIG MAXIMILIANS UNIV,INST BOT,MENZINGERSTR 67,W-8000 MUNICH 19,GERMANY. HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. NR 35 TC 7 Z9 7 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-4412 J9 PLANT MOL BIOL JI Plant Mol.Biol. PD JAN PY 1991 VL 16 IS 1 BP 129 EP 139 DI 10.1007/BF00017923 PG 11 WC Biochemistry & Molecular Biology; Plant Sciences SC Biochemistry & Molecular Biology; Plant Sciences GA EV082 UT WOS:A1991EV08200012 PM 1888891 ER PT J AU BUSH, RK AF BUSH, RK TI NOCTURNAL ASTHMA - MECHANISMS AND THE ROLE OF THEOPHYLLINE IN TREATMENT SO POSTGRADUATE MEDICAL JOURNAL LA English DT Article; Proceedings Paper CT SYMP ON OBSTRUCTIVE AIRWAYS DISEASE : A THERAPEUTIC PARADOX CY OCT 12-13, 1990 CL KILLARNEY, IRELAND ID SUSTAINED-RELEASE THEOPHYLLINE; HOUSE DUST; CORTISOL; THERAPY; NIGHT AB Asthma is characterized by airway inflammation and hyper-responsiveness. Clinically, these features are manifested by attacks of cough, wheezing, and dyspnoea. Nocturnal asthma symptoms are frequent; 39% of asthmatics awaken nightly, and 94% have nocturnal awakenings at least once a month. A number of mechanisms have been hypothesized to explain the phenomenon of nocturnal asthma, including exposure to dust mite allergen, late-phase allergic reactions, effects of posture and sleep stage on airway tone, gastro-oesophageal reflex, impaired mucociliary clearance, airway cooling, and changes in circadian rhythms of circulating hormones. While no single mechanism can explain these changes, circadian rhythms may be particularly relevant. Normal airway tone increases during sleep and is magnified in asthmatics. Bronchial responsiveness to histamine and allergen challenge increases during sleep and mast cell mediator release is enhanced. Circulating eosinophils increase, which may allow their ingress into pulmonary tissue. Decreases in plasma catecholamine and cortisol levels have also been observed. All of these may influence airway tone, inflammation, and responsiveness during sleep and produce the observed clinical picture. Inhaled sympathomimetics are frequently ineffective in preventing nocturnal symptoms due to their short duration of action. While corticosteroids, cromoglycate, and anticholinergics are effective, sustained-release theophylline is particularly advantageous for controlling nocturnal symptoms. Once-daily theophylline when dosed in the evening not only controls nocturnal symptoms and improves airflow during the early morning hours, but decreases airway responsiveness to histamine as well. The close association between airway inflammation, airway hyper-responsiveness, and nocturnal asthma symptoms makes further studies of the mechanism of action of theophylline especially interesting. C1 UNIV WISCONSIN,MADISON,WI 53706. RP BUSH, RK (reprint author), WILLIAM S MIDDLETON MEM VET ADM MED CTR,2500 OVERLOOK TERRACE,MADISON,WI 53705, USA. NR 33 TC 7 Z9 7 U1 0 U2 2 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR SN 0032-5473 J9 POSTGRAD MED J JI Postgrad. Med. J. PY 1991 VL 67 SU 4 BP S20 EP S24 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA GG257 UT WOS:A1991GG25700004 PM 1758831 ER PT J AU LIVINGSTON, EH PASSARO, EP AF LIVINGSTON, EH PASSARO, EP TI RESUSCITATION - REVIVAL SHOULD BE THE 1ST PRIORITY SO POSTGRADUATE MEDICINE LA English DT Article AB Successful resuscitation requires prompt and appropriate response from medical personnel. Drs Livingston and Passaro describe the initial steps common to all resuscitative efforts and discuss often-observed maneuvers that should not be part of the initial management of critically ill patients. Their helpful ABCDEF mnemonic summarizes the steps needed for revival. RP LIVINGSTON, EH (reprint author), W LOS ANGELES VET AFFAIRS MED CTR,BLDG 115,ROOM 107,LOS ANGELES,CA 90073, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD JAN PY 1991 VL 89 IS 1 BP 117 EP 122 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA ET943 UT WOS:A1991ET94300009 PM 1985304 ER PT J AU STEPHENSON, DA MERCOLA, M ANDERSON, E WANG, CY STILES, CD BOWENPOPE, DF CHAPMAN, VM AF STEPHENSON, DA MERCOLA, M ANDERSON, E WANG, CY STILES, CD BOWENPOPE, DF CHAPMAN, VM TI PLATELET-DERIVED GROWTH-FACTOR RECEPTOR ALPHA-SUBUNIT GENE (PDGFRA) IS DELETED IN THE MOUSE PATCH (PH) MUTATION SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE DEVELOPMENT; DOMINANT SPOTTING; LINKAGE ANALYSIS; HUMAN HOMOLOG ID C-KIT; W-LOCUS; PROTO-ONCOGENE; KINASE; MICE; EXPRESSION; EMBRYOS; FAMILY AB Platelet-derived growth factor receptors are composed of two subunits (alpha and beta) that associate with one another to form three functionally active dimeric receptor species. The two subunits are encoded by separate loci in humans and other species. In this study, we used conventional interspecific backcross mapping and an analysis of a deletional mutation to establish close linkage between the alpha-subunit gene (Pdgfra) and the dominant spotting (W) locus on mouse chromosome 5. Further, by analyzing the restriction fragment length polymorphisms in interspecific F1 hybrids, we were able to demonstrate that the closely associated patch (Ph) locus carries a deletion in Pdgfra. This observation was confirmed by both DNA and RNA analysis of 10.5-day fetuses produced from crosses between Ph heterozygotes. Out of 16 fetuses analyzed, Pdgfra genomic sequences were absent and no mRNA for the receptor was detected in 6 fetuses that were developmentally abnormal (the presumptive Ph homozygotes). We also determined that the deletion associated with the Ph mutation does not extend into the coding sequences of the adjacent Kit gene, by analysis of the genomic DNA from both the interspecific F1 hybrids and the presumptive Ph homozygotes. The absence of Pdgfra genomic sequences and the lack of detectable message associated with the Ph mutation should make this mutant a valuable asset for understanding the role of the receptor alpha-subunit during mammalian development. C1 NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT MOLEC & CELLULAR BIOL,ELM & CARLTON ST,BUFFALO,NY 14263. UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195. HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELLULAR & MOLEC BIOL,BOSTON,MA 02115. FU NICHD NIH HHS [P01HD24926]; NIGMS NIH HHS [GM33160, GM35501] NR 27 TC 196 Z9 196 U1 1 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN PY 1991 VL 88 IS 1 BP 6 EP 10 DI 10.1073/pnas.88.1.6 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EQ544 UT WOS:A1991EQ54400002 PM 1846043 ER PT J AU LEIB, DA NADEAU, KC RUNDLE, SA SCHAFFER, PA AF LEIB, DA NADEAU, KC RUNDLE, SA SCHAFFER, PA TI THE PROMOTER OF THE LATENCY-ASSOCIATED TRANSCRIPTS OF HERPES-SIMPLEX VIRUS TYPE-1 CONTAINS A FUNCTIONAL CAMP-RESPONSE ELEMENT - ROLE OF THE LATENCY-ASSOCIATED TRANSCRIPTS AND CAMP IN REACTIVATION OF VIRAL LATENCY SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE PROTEIN KINASE-A; CAMP-RESPONSE ELEMENT-BINDING PROTEIN; PC12 CELLS; VIRAL PATHOGENESIS ID NERVE GROWTH-FACTOR; PROTEIN-KINASE-C; LONG UNIQUE REGION; CYCLIC-AMP; MESSENGER-RNA; MACROMOLECULAR-SYNTHESIS; TRIGEMINAL GANGLIA; GENE; INDUCTION; CELLS AB A 203-base-pair sequence 5' of the latency-associated transcripts (LATs) of herpes simplex virus type 1 contains a 7-base consensus sequence TGCGTCA that is identical to the cAMP-response element of the proenkepahlin gene. This consensus sequence is at -38 relative to the putative 5' end of the LATs with a TAT Abox at the -24 position. In transient chloramphenicol acetyltransferase assays in rat pheochromocytoma (PC12) cells, this enhancer region stimulated gene expression up to 3-fold in the presence of dibutyryl cAMP, forskolin, nerve growth factor, or phorbol 12-myristate 13-acetate. Mutation of the cAMP-response element to TGCGCAA resulted in a 4-fold reduction of basal activity and a complete loss of inducible stimulation. In DNA gel retardation assays, purified cAMP-response element-binding protein and a nuclear protein from PC12 cells were shown to bind specifically to this element. Furthermore, it was demonstrated that the reactivation of wild-type herpes simplex virus type 1 from dissociated latently infected murine trigeminal ganglia was significantly accelerated (P < 0.005) by the addition of cAMP analogs or adenylate cyclase activators. However, these reagents did not accelerate reactivation of a deletion mutant that lacks the putative cAMP-response element-containing promoter region, transcriptional start site, and 1015 base pairs of the LATs. These studies demonstrate that the promoter region of the LATs contains a functional cAMP-response element and that expression of the LATs is likely controlled by second messenger signal transduction and imply a role for cAMP in triggering viral reactivation. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,TUMOR VIRUS GENET LAB,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DIV MED SCI,BOSTON,MA 02115. FU NIAID NIH HHS [P01 AI24010] NR 51 TC 127 Z9 128 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN PY 1991 VL 88 IS 1 BP 48 EP 52 DI 10.1073/pnas.88.1.48 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EQ544 UT WOS:A1991EQ54400011 PM 1846042 ER PT J AU ROCK, KL GAMBLE, S ROTHSTEIN, L BENACERRAF, B AF ROCK, KL GAMBLE, S ROTHSTEIN, L BENACERRAF, B TI REASSOCIATION WITH BETA-2-MICROGLOBULIN IS NECESSARY FOR DB CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX BINDING OF AN EXOGENOUS INFLUENZA PEPTIDE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE ANTIGEN PRESENTATION; CYTOTOXIC-T; LYMPHOCYTE; VACCINES ID TOXIC LYMPHOCYTES-T; ANTIGEN PRESENTATION; CELLS; RECOGNITION; BETA-2-MICROGLOBULIN; ASSOCIATION AB A synthetic peptide corresponding to residues 365-380 of the infleunza nucleoprotein (NP365-380) has been previously shown to associate with class I major histocompatibility complex-encoded molecules and to stimulate cytotoxic T lymphocytes [Townsend, A.R.M., Rothbard, J., Gotch, F.M., Bahadur, G., Wraith, D. & McMichael, A.J. 1986) Cell 44, 959-968]. We find that intact D(b) class I heterodimers on the cell surface was unreceptive to binding this antigen. However, NP365-380 readily associates with D(b) molecules on the plasma membrane in the presence of exogenous beta-2-microglobulin. In addition, there is a second pathway through which this peptide associates with class I molecules that requires energy and de novo protein synthesis. These findings have implications for maintaining the immunological identity of cells and for the use of peptides as vaccines for priming cytolytic T-cell immunity. C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. RP ROCK, KL (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV LYMPHOCYTE BIOL,BOSTON,MA 02115, USA. FU NIAID NIH HHS [AI-20248] NR 27 TC 65 Z9 66 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN PY 1991 VL 88 IS 1 BP 301 EP 304 DI 10.1073/pnas.88.1.301 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EQ544 UT WOS:A1991EQ54400064 PM 1986378 ER PT J AU ANTONIADES, HN GALANOPOULOS, T NEVILLEGOLDEN, J KIRITSY, CP LYNCH, SE AF ANTONIADES, HN GALANOPOULOS, T NEVILLEGOLDEN, J KIRITSY, CP LYNCH, SE TI INJURY INDUCES INVIVO EXPRESSION OF PLATELET-DERIVED GROWTH-FACTOR (PDGF) AND PDGF RECEPTOR MESSENGER-RNAS IN SKIN EPITHELIAL-CELLS AND PDGF MESSENGER-RNA IN CONNECTIVE-TISSUE FIBROBLASTS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE GENE EXPRESSION; CHRONIC INJURY; WOUND HEALING; CHRONIC ULCERS; EPITHELIUM ID FACTOR-BETA; WOUNDS; SECRETION; PROTEINS; CULTURE; LINES AB Platelet-derived growth factor (PDGF) stimulates many of the processes important in tissue repair, including proliferation of fibroblasts and synthesis of extracellular matrices. In this study we have demonstrated with in situ hybridization and immunocytochemistry the reversible expression of c-sis/PDGF-2 and PDGF receptor (PDGF-R) b mRNAs and their respective protein products in epithelial cells and fibroblasts following cutaneous injury in pigs. Epithelial cells in control, unwounded skin did not express c-sis and PDGF-R mRNAs, and fibroblasts expressed only PDGF-R mRNA. The expression levels in the injured site were correlated with the stage of tissue repair, being highest during the initial stages of the repair process and declining at the time of complete re-epithelialization and tissue remodeling. It is suggested that the controlled, reversible expression of a potent mitogen and its receptor induced by injury may function in an autocrine/paracrine manner on both epithelial cells and fibroblasts to bring about their sustained proliferation during the normal healing process. These studies provide a molecular basis for understanding the mechanisms contributing to normal tissue repair. We suggest the possibility that a defect in these mechanisms may be associated with defective wound healing. It is also conceivable that "chronic" injury may induce irreversible gene expression leading to pathologic, unregulated cell growth. C1 HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115. HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,BOSTON,MA 02115. INST MOLEC BIOL,BOSTON,MA 02115. HARVARD UNIV,SCH DENT MED,DEPT PERIODONT,BOSTON,MA 02115. RP ANTONIADES, HN (reprint author), CTR BLOOD RES,800 HUNTINGTON AVE,BOSTON,MA 02115, USA. FU NCI NIH HHS [CA30101]; NHLBI NIH HHS [HL29583] NR 24 TC 183 Z9 185 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN PY 1991 VL 88 IS 2 BP 565 EP 569 DI 10.1073/pnas.88.2.565 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA ET521 UT WOS:A1991ET52100052 PM 1846446 ER PT J AU FISHMAN, MC VALENZUELA, D AF FISHMAN, MC VALENZUELA, D TI GAP-43 AND NEURONAL REMODELING SO PROGRESS IN BRAIN RESEARCH LA English DT Review ID CALMODULIN-BINDING PROTEIN; GROWTH-RELATED PROTEIN; KINASE-C SUBSTRATE; GENE-EXPRESSION; NERVOUS-SYSTEM; CONE PROTEIN; MEMBRANE; LOCALIZATION; CLONING; DOMAIN RP MASSACHUSETTS GEN HOSP, DEV BIOL LAB, BOSTON, MA 02114 USA. NR 35 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0079-6123 J9 PROG BRAIN RES JI Prog. Brain Res. PY 1991 VL 89 BP 89 EP 95 PG 7 WC Neurosciences SC Neurosciences & Neurology GA GZ403 UT WOS:A1991GZ40300008 ER PT B AU LYNCH, DC AF LYNCH, DC BE RUGGERI, ZM FULCHER, CA WARE, J TI THE FINE-STRUCTURE OF VONWILLEBRAND-FACTOR MULTIMERS AND TYPE-IIA VONWILLEBRAND DISEASE SO PROGRESS IN VASCULAR BIOLOGY, HEMOSTASIS, AND THROMBOSIS: THEODORE S ZIMMERMAN MEMORIAL CONFERENCE SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT THEODORE S ZIMMERMAN MEMORIAL CONF : PROGRESS IN VASCULAR BIOLOGY, HEMOSTASIS AND THROMBOSIS CY FEB 28-MAR 03, 1990 CL LA JOLLA, CA SP FARMITALIA CARLO ERBA, RORER, ARMOUR PHARM, BAXTER HEALTHCARE, KABIVITRUM, CORVAS, DUPONT CO, GLAXO RES LAB, R W JOHNSON PHARM RES INST, LILLY RES LAB ID HUMAN-ENDOTHELIAL CELLS; FACTOR VWF CDNA; ANTIHEMOPHILIC FACTOR; SUBUNIT COMPOSITION; BIOSYNTHESIS; ANTIGEN; PROTEIN; POLYPEPTIDE; EXPRESSION; SECRETION RP LYNCH, DC (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,44 BINNEY ST,BOSTON,MA 02115, USA. FU NHLBI NIH HHS [HL31311] NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-646-1 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 614 BP 138 EP 152 DI 10.1111/j.1749-6632.1991.tb43699.x PG 15 WC Biochemistry & Molecular Biology; Hematology SC Biochemistry & Molecular Biology; Hematology GA BT59L UT WOS:A1991BT59L00013 PM 2024881 ER PT B AU PARKER, J LANE, J AXELROD, L AF PARKER, J LANE, J AXELROD, L BE SAMUELSSON, B RAMWELL, PW PAOLETTI, R FOLCO, G GRANSTROM, E TI COOPERATION OF ADIPOCYTES AND ENDOTHELIAL-CELLS IS NECESSARY FOR CATECHOLAMINE-STIMULATED PGI2 PRODUCTION BY RAT ADIPOSE-TISSUE SO PROSTAGLANDINS AND RELATED COMPOUNDS, VOLS A AND B SE ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH LA English DT Review CT 7TH INTERNATIONAL CONF ON PROSTAGLANDINS AND RELATED COMPOUNDS CY MAY 28-JUN 01, 1990 CL FLORENCE, ITALY RP PARKER, J (reprint author), MASSACHUSETTS GEN HOSP,DIABET UNIT,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU RAVEN PRESS PI NEW YORK PA NEW YORK BN 0-88167-742-6 J9 ADV PROSTAG THROMB L PY 1991 VL 21 BP 659 EP 662 PG 4 WC Biochemistry & Molecular Biology; Medicine, Research & Experimental; Multidisciplinary Sciences SC Biochemistry & Molecular Biology; Research & Experimental Medicine; Science & Technology - Other Topics GA BS15B UT WOS:A1991BS15B00144 PM 1825394 ER PT B AU FISHMAN, MC VALENZUELA, D AF FISHMAN, MC VALENZUELA, D BE GISPEN, WH ROUTTENBERG, A TI GAP-43 AND NEURONAL REMODELING SO PROTEIN KINASE C AND ITS BRAIN SUBSTRATES : ROLE IN NEURONAL GROWTH AND PLASTICITY SE PROGRESS IN BRAIN RESEARCH LA English DT Proceedings Paper CT 3RD INTERNATIONAL MEETING ON BRAIN PHOSPHOPROTEINS CY AUG 24-26, 1990 CL ZEIST, NETHERLANDS SP PHARM STUDIEFONDS UTRECHT, UNIV UTRECHT, ELSEVIER SCI PUBL, FIDIA RES LABS ID CALMODULIN-BINDING PROTEIN; GROWTH-RELATED PROTEIN; KINASE-C SUBSTRATE; GENE-EXPRESSION; NERVOUS-SYSTEM; CONE PROTEIN; MEMBRANE; LOCALIZATION; CLONING; DOMAIN RP FISHMAN, MC (reprint author), MASSACHUSETTS GEN HOSP,DEV BIOL LAB,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL B V PI AMSTERDAM PA AMSTERDAM BN 0-444-81436-1 J9 PROG BRAIN RES PY 1991 VL 89 BP 89 EP 95 PG 7 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA BU95D UT WOS:A1991BU95D00008 ER PT J AU CAMPBELL, A YEGHIAYAN, S BALDESSARINI, RJ NEUMEYER, JL AF CAMPBELL, A YEGHIAYAN, S BALDESSARINI, RJ NEUMEYER, JL TI SELECTIVE ANTIDOPAMINERGIC EFFECTS OF S(+)N-N-PROPYLNORAPORPHINES IN LIMBIC VERSUS EXTRAPYRAMIDAL SITES IN RAT-BRAIN - COMPARISONS WITH TYPICAL AND ATYPICAL ANTIPSYCHOTIC AGENTS SO PSYCHOPHARMACOLOGY LA English DT Article DE ANTIPSYCHOTICS; S(+)APORPHINES; CLOZAPINE; DOPAMINE; ICI-204,636 ID DOPAMINE; CLOZAPINE; DRUGS; APOMORPHINE; STRIATUM; SYSTEM AB Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing was done with an ED50 dose of DA (16-mu-g). Systemic injections (IP) of the representative typical neuroleptic haloperidol showed high potency and minor striatal selectivity against the behavioral effect of intracerebral DA [accumbens ID50 = 0.090, striatum = 0.027 mg/kg (0.24 and 0.072-mu-mol/kg); ID50 ratio = 3.3, favoring striatum]. The atypical antipsychotic agent clozapine was less potent against DA in both brain regions but, paradoxically, showed ever greater striatal selectivity [ID50 = 12 and 1.4 mg/kg (37 and 4.2-mu-mol/kg); ratio = 8.8, favoring striatum], while its analog, the piperazinyl-dibenzothiazepine ICI-204,636 showed intermediate potency and the lowest striatal selectivity of these three neuroleptic agents [ID50 = 1.8 and 0.88 mg/kg (4.1 and 2.0-mu-mol/kg); ratio = 2.1]. In striking contrast, the S(+) isomers of N-n-propylnorapomorphine, its orally active 10,11-methylenedioxy prodrug derivative, and its 11-monohydroxy analog all induced potent antagonism of limbic DA but had little effect on extrapyramidal injections of DA except at high systemic doses [ID50,accumbens = 0.18-0.52, striatal = 10-15 mg/kg (0.50-1.6 and 29-42-mu-mol/kg); regional ID50 ratios = 18-69, favoring accumbens]. The S(+)aporphine showed limbic potency similar to that of haloperidol and 25-73 times greater than that of clozapine. The S(+)11-OH-aporphine was 2.7-3.1 times more potent (on a molar dose basis) than the other aporphines against DA in accumbens, and 0.5, 8 and 73 times as potent as haloperidol, ICI-204,636 and clozapine. The significantly dissimilar slopes of dose-effect functions for the two groups of agents suggest that different actions may mediate the limbic effects of the aporphines and the neuroleptics tested. ICI-204-636 appears to be pharmacologically similar to clozapine, but 2.1 times more potent versus limbic-DA. The S(+)N-n-propylnoraporphines are potent and regionally highly selective limbic DA antagonists and S(+)-11-hydroxy-N-n-propylnoraporphine is orally active. These and other aporphine analogs are proposed for development as potential atypical antipsychotic agents with a low risk of extrapyramidal neurological side effects, and the present methods are proposed for predicting relative limbic versus extrapyramidal antidopaminergic activity. C1 HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,MCLEAN DIV,MAILMAN RES CTR,BELMONT,MA 02178. NORTHEASTERN UNIV,COLL PHARM & ALLIED HLTH PROFESS,MED CHEM SECT,BOSTON,MA 02115. FU NIMH NIH HHS [MH-34006, MH-47370, MH-36224] NR 26 TC 28 Z9 28 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PY 1991 VL 103 IS 3 BP 323 EP 329 DI 10.1007/BF02244285 PG 7 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA EY004 UT WOS:A1991EY00400007 PM 1676180 ER PT J AU VANPUTTEN, T ARAVAGIRI, M MARDER, SR WIRSHING, WC MINTZ, J CHABERT, N AF VANPUTTEN, T ARAVAGIRI, M MARDER, SR WIRSHING, WC MINTZ, J CHABERT, N TI PLASMA FLUPHENAZINE LEVELS AND CLINICAL-RESPONSE IN NEWLY ADMITTED SCHIZOPHRENIC-PATIENTS SO PSYCHOPHARMACOLOGY BULLETIN LA English DT Article; Proceedings Paper CT 30TH ANNUAL MEETING OF THE NEW CLINICAL DRUG EVALUATION UNIT CY MAY 29-JUN 01, 1990 CL KEY BISCAYNE, FL SP NIMH, DIV CLIN RES ID RADIOIMMUNOASSAY AB Seventy-two newly readmitted, drug-free men with the diagnosis of schizophrenia by DSM-III were assigned randomly to receive fluphenazine hydrochloride at 5 mg, 10 mg, or 20 mg daily for 4 weeks. Fluphenazine (FLU), fluphenazine sulfoxide, 7-hydroxyfluphenazine, and fluphenazine N-oxide were measured by highly specific and sensitive radioimmunoassays. Data were analyzed by logistic regression using the Clinical Global Impressions Disabling Side Effects and Global Improvement as the outcome measures. Disabling side effects were defined as "side effects that significantly interfered with patient's functioning" or "side effects that outweigh therapeutic effects" (National Institute of Mental Health 1985, p. 839). Higher plasma FLU levels (up to 4.23 ng/mL) were significantly (p = .015) associated with a higher rate of global improvement. However, close to 90 percent of these acute patients had disabling side effects at a plasma FLU level of 2.7 ng/mL. At least in the patient's view, these disabling side effects negated or compromised the improvement in psychosis. Fluphenazine N-oxide may be a toxic metabolite in that it was more powerfully associated with side effects than was the parent FLU. RP VANPUTTEN, T (reprint author), UNIV CALIF LOS ANGELES,W LOS ANGELES VET AFFAIRS MED CTR,11301 WILSHIRE BLVD,BLDG 210C,LOS ANGELES,CA 90073, USA. NR 16 TC 15 Z9 16 U1 0 U2 0 PU US GOVERNMENT PRINTING OFFICE PI WASHINGTON PA SUPT OF DOCUMENTS, WASHINGTON, DC 20402-9325 SN 0048-5764 J9 PSYCHOPHARMACOL BULL JI Psychopharmacol. Bull. PY 1991 VL 27 IS 2 BP 91 EP 96 PG 6 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA GA037 UT WOS:A1991GA03700002 PM 1924666 ER PT J AU FAVA, M ROSENBAUM, JF MCCARTHY, M PAVA, J STEINGARD, R BLESS, E AF FAVA, M ROSENBAUM, JF MCCARTHY, M PAVA, J STEINGARD, R BLESS, E TI ANGER ATTACKS IN DEPRESSED OUTPATIENTS AND THEIR RESPONSE TO FLUOXETINE SO PSYCHOPHARMACOLOGY BULLETIN LA English DT Article; Proceedings Paper CT 29TH ANNUAL MEETING OF THE AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY CY DEC, 1990 CL SAN JUAN, PR SP AMER COLL NEUROPSYCHOPHARM ID DISORDERS AB "Anger attacks" are spells of anger that are inappropriate to the situation and have physical features resembling panic attacks. The Anger Attacks Questionnaire, designed to assess these attacks, was administered to 79 consecutive patients (25 men and 54 women, mean age 38.8 +/- 10.3 years) diagnosed as having major depression with the Structured Clinical Interview for DSM-III-R. Of these 79 depressed patients, 34 (13 men and 21 women) reported having anger attacks according to our criteria. The prevalence of anger attacks in a group of 31 younger depressed patients (48%) was significantly higher (p = .048) than that of 29 normal controls (21%) of similar age. Of the 79 depressed patients, 19 (7 men, 12 women) were treated openly with fluoxetine at 20 mg/day for at least 8 weeks. At pretreatment, 9 patients (47%) had reported anger attacks, only 3 (16%) continued to report them after treatment, and the difference was statistically significant (p < .05). C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP FAVA, M (reprint author), MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,WACC 815,15 PARKMAN ST,BOSTON,MA 02114, USA. NR 12 TC 106 Z9 106 U1 1 U2 3 PU US GOVERNMENT PRINTING OFFICE PI WASHINGTON PA SUPT OF DOCUMENTS, WASHINGTON, DC 20402-9325 SN 0048-5764 J9 PSYCHOPHARMACOL BULL JI Psychopharmacol. Bull. PY 1991 VL 27 IS 3 BP 275 EP 279 PG 5 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA GP897 UT WOS:A1991GP89700016 PM 1775598 ER PT J AU WULSIN, LR JACOBSON, AM RAND, LI AF WULSIN, LR JACOBSON, AM RAND, LI TI PSYCHOSOCIAL CORRELATES OF MILD VISUAL-LOSS SO PSYCHOSOMATIC MEDICINE LA English DT Article ID DIABETIC-RETINOPATHY; BLINDNESS AB Studies of the psychosocial aspects of visual impairment have emphasized the effects of blindness, giving relatively little attention to the effects of mild or partial visual impairment. Consequently, we know little about when in the course of visual loss significant psychosocial dysfunction develops. To address this question, we assessed psychosocial functioning at three times over eight months in 31 adults with proliferative diabetic retinopathy and mild to moderate visual impairment in at least one eye. Examination of the correlations between visual and psychosocial measures revealed strong and significant correlations between visual acuity and adjustment (range of r = -0.45 to -0.68), between visual acuity and psychological symptoms (range of r = -0.39 to -0.50), and between visual acuity and emotion-focused coping (range of r = -0.38 to -0.53). The strength of these correlations and their occurrence in three independent measures of psychosocial functioning suggest a clinically meaningful relationship between visual and psychosocial functioning in the range of mild to moderate visual impairment. Psychosocial dysfunction related to visual impairment develops long before blindness. Further prospective research on the psychosocial aspects of partial visual impairment will clarify this relationship and may help justify early intervention with rehabilitation in the visually impaired who do not qualify for services for the blind. C1 HARVARD UNIV,SCH MED,JOSLIN DIABET CTR,MENTAL HLTH UNIT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,JOSLIN DIABET CTR,BEETHAM EYE UNIT,BOSTON,MA 02115. RP WULSIN, LR (reprint author), UNIV CINCINNATI,DEPT PSYCHIAT,231 BETHESDA AVE,CINCINNATI,OH 45267, USA. FU NIDDK NIH HHS [DK 27845]; NIMH NIH HHS [T32 MH 16259] NR 32 TC 28 Z9 28 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0033-3174 J9 PSYCHOSOM MED JI Psychosom. Med. PD JAN-FEB PY 1991 VL 53 IS 1 BP 109 EP 117 PG 9 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA EV350 UT WOS:A1991EV35000010 PM 2011646 ER PT J AU ROSENBERG, AE AF ROSENBERG, AE TI THE PATHOLOGY OF METABOLIC BONE-DISEASE SO RADIOLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID ALUMINUM; OSTEOPETROSIS; OSTEOMALACIA; DIALYSIS; BIOPSY C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. RP ROSENBERG, AE (reprint author), MASSACHUSETTS GEN HOSP,DEPT BONE & SOFT TISSUE PATHOL,32 FRUIT ST,BOSTON,MA 02114, USA. NR 43 TC 10 Z9 10 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0033-8389 J9 RADIOL CLIN N AM JI Radiol. Clin. N. Am. PD JAN PY 1991 VL 29 IS 1 BP 19 EP 36 PG 18 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA ET794 UT WOS:A1991ET79400003 PM 1985327 ER PT J AU MAYOSMITH, W ROSENTHAL, DI AF MAYOSMITH, W ROSENTHAL, DI TI RADIOGRAPHIC APPEARANCE OF OSTEOPENIA SO RADIOLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID BONE; OSTEOPOROSIS; WOMEN C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,32 FRUIT ST,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,CTR WANG AMBULATORY CARE,BOSTON,MA 02114. NR 37 TC 14 Z9 14 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0033-8389 J9 RADIOL CLIN N AM JI Radiol. Clin. N. Am. PD JAN PY 1991 VL 29 IS 1 BP 37 EP 47 PG 11 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA ET794 UT WOS:A1991ET79400004 PM 1985328 ER PT J AU CHEW, FS AF CHEW, FS TI RADIOLOGIC MANIFESTATIONS IN THE MUSCULOSKELETAL SYSTEM OF MISCELLANEOUS ENDOCRINE DISORDERS SO RADIOLOGIC CLINICS OF NORTH AMERICA LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115. RP CHEW, FS (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,32 FRUIT ST,BOSTON,MA 02114, USA. OI Chew, Felix/0000-0003-2711-2013 NR 38 TC 11 Z9 11 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0033-8389 J9 RADIOL CLIN N AM JI Radiol. Clin. N. Am. PD JAN PY 1991 VL 29 IS 1 BP 135 EP 147 PG 13 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA ET794 UT WOS:A1991ET79400010 PM 1985324 ER PT J AU OKEEFFE, D AF OKEEFFE, D TI MORPHOMETRY SO RADIOLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID COMPUTED-TOMOGRAPHY; CORTICAL THICKNESS; TRABECULAR BONE; OSTEOPOROSIS; WOMEN; FRACTURES; INDEX C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. MANCHESTER ROYAL INFIRM,DEPT RADIOL,MANCHESTER M13 9WL,LANCS,ENGLAND. NR 37 TC 8 Z9 8 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0033-8389 J9 RADIOL CLIN N AM JI Radiol. Clin. N. Am. PD JAN PY 1991 VL 29 IS 1 BP 165 EP 174 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA ET794 UT WOS:A1991ET79400012 PM 1985326 ER PT J AU ELIZONDO, G FRETZ, CJ STARK, DD ROCKLAGE, SM QUAY, SC WORAH, D TSANG, YM CHEN, MCM FERRUCCI, JT AF ELIZONDO, G FRETZ, CJ STARK, DD ROCKLAGE, SM QUAY, SC WORAH, D TSANG, YM CHEN, MCM FERRUCCI, JT TI PRECLINICAL EVALUATION OF MNDPDP - NEW PARAMAGNETIC HEPATOBILIARY CONTRAST AGENT FOR MR IMAGING SO RADIOLOGY LA English DT Article DE CONTRAST MEDIA, EFFECTS; CONTRAST MEDIA, TOXICITY; LIVER, MR STUDIES; MAGNETIC RESONANCE (MR), CONTRAST ENHANCEMENT; MANGANESE ID LIVER-CANCER; GADOLINIUM-DTPA; IRON-EHPG; MANGANESE; TOXICITY; RAT; ENHANCEMENT; VITAMIN-B6; METABOLISM; COMPLEX AB Manganese (II)-N,N'-dipyridoxy-lethylenediamine-N,N'-diacetate-5,5'-bis(phosphate) (MnDPDP) is a paramagnetic complex designed for use as a hepatobiliary agent. The T1 relaxivity of MnDPDP (2.8 [mmol/L]-1. sec-1 in aqueous solution) was similar to that of gadolinium diethylenetriaminepentaacetic acid (DTPA) (4.5 [mmol/L]-1. sec-1) and gadolinium tetraazocyclodecanetetraacetic acid (DOTA) (3.8[mmol/L]-1.sec-1). However, in liver tissue the T1 relaxivity of MnDPDP (21.7 [mmol/L]-1.sec-1) was threefold higher than that reported for Gd-DOTA (6.7 [mmol/L]-1.sec-1). Maximum liver T1 relaxation enhancement occurred 30 minutes after injection of MnDPDP, at which time (MnDPDP)-Mn-54 biodistribution studies indicated that 13% of total body activity was in the liver. Enhanced (MnDPDP,50-mu-mol/kg) MR images showed a fivefold increase in tumor-liver contrast-to-noise ratio over baseline unenhanced images. Results of the authors' acute and subchronic toxicity studies suggest that MnDPDP will be safe at the doses necessary for clinical imaging; at 10-mu-mol/kg, the safe factor (LD50/effective dose) for MnDPDP is 540, significantly greater than the safety factor of Gd-DTPA (ie,60-100). C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,32 FRUIT ST,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. SALUTAR INC,SUNNYVALE,CA. NR 47 TC 183 Z9 187 U1 0 U2 16 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JAN PY 1991 VL 178 IS 1 BP 73 EP 78 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EP117 UT WOS:A1991EP11700014 PM 1898538 ER PT J AU LIM, KO STARK, DD LEESE, PT PFEFFERBAUM, A ROCKLAGE, SM QUAY, SC AF LIM, KO STARK, DD LEESE, PT PFEFFERBAUM, A ROCKLAGE, SM QUAY, SC TI HEPATOBILIARY MR IMAGING - 1ST HUMAN-EXPERIENCE WITH MNDPDP SO RADIOLOGY LA English DT Article DE CONTRAST MEDIA; LIVER, MR STUDIES; MANGANESE ID GADOLINIUM-DTPA; CONTRAST AGENT; INJECTION; CANCER; RABBIT; LIVER; CT AB The first human MR imaging results for the hepatobiliary contrast agent manganese(II)N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate)(MnDPDP) are reported. MnDPDP is a paramagnetic contrast agent specific for hepatobiliary imaging. An imaging study was performed to investigate the presence of contrast enhancement or facilitated visualization of normal structures. Twelve healthy subjects receiving MnDPDP at doses of 3, 10, or 15-mu-mol/kg were imaged after injection for approximately 30 minutes at 1-5-minute intervals. Transaxial abdominal images were obtained at 1.5 T in a single breathhold interval of 21 seconds with use of a spin-echo pulse sequence (repetition time = 150 msec, echo time = 20 msec). Liver parenchyma enhancement was observed 1 minute after injection and persisted for at least 30 minutes. Clearance into the gallbladder was visualized within 15 minutes. Enhancement was dose-dependent; a dose of 10-mu-mol/kg produced a 75%-100% signal enhancement of the liver at 10 minutes after injection. C1 VET AFFAIRS MED CTR,PALO ALTO,CA 94304. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL,BOSTON,MA 02114. QUINCY RES CTR,KANSAS CITY,MO. SALUTAR INC,SUNNYVALE,CA. RP LIM, KO (reprint author), STANFORD UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,PHYSIOL & STRUCT BRAIN IMAGING LAB,PALO ALTO,CA 94304, USA. NR 9 TC 118 Z9 125 U1 0 U2 5 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JAN PY 1991 VL 178 IS 1 BP 79 EP 82 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EP117 UT WOS:A1991EP11700015 PM 1898539 ER PT J AU SHTERN, F GARRIDO, L COMPTON, C SWINIARSKI, JK LAUFFER, RB BRADY, TJ AF SHTERN, F GARRIDO, L COMPTON, C SWINIARSKI, JK LAUFFER, RB BRADY, TJ TI MR IMAGING OF BLOOD-BORNE LIVER METASTASES IN MICE - CONTRAST ENHANCEMENT WITH FE-EHPG SO RADIOLOGY LA English DT Article DE CONTRAST MEDIA, EXPERIMENTAL STUDIES; IRON; LIVER NEOPLASMS, MR STUDIES; LIVER NEOPLASMS, SECONDARY; MAGNETIC RESONANCE (MR), CONTRAST ENHANCEMENT ID HEPATIC METASTASES; IRON-EHPG; AGENT; DTPA; CT AB To determine whether iron(III)ethylenebis-(2-hydrophenylglycine) (Fe-EHPG), a prototype hepatobiliary magnetic resonance imaging agent, can enhance the liver-to-tumor contrast-to-noise ratio (C/N) in models of liver tumors in mice, two types of cell inoculation were used: intrahepatic implantation of M5076 sarcoma and intrasplenic injection of colon tumor (C-26) or M5076 sarcoma. Significant enhancement of the liver-to-tumor C/N and/or improved visualization of small lesions was consistently observed on T1-weighted images obtained after injection of the contrast material. For intrahepatic implants, the C/N on postinjection T1-weighted images was superior to that on T1- and T2-weighted preinjection images. For the C-26 metastatic liver lesions of larger diameter ( > 5 mm), the C/N on postinjection T1-weighted studies was superior to that on preinjection T1-weighted images but was comparable to that on preinjection T2-weighted images. However, higher C/N after administration of Fe-EHPG improved visualization of medium-sized (3-5-mm) and small (1-3-mm) metastatic lesions in both M5076 and C-26 models. These results demonstrate that MR imaging with appropriate hepatobiliary agents appears promising for early detection of liver metastases. C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. ARTHUR D LITTLE INC,CAMBRIDGE,MA 02140. RI Garrido, Leoncio/K-3092-2014 OI Garrido, Leoncio/0000-0002-7587-1260 FU NCI NIH HHS [T32 CA09502] NR 20 TC 24 Z9 24 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JAN PY 1991 VL 178 IS 1 BP 83 EP 89 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EP117 UT WOS:A1991EP11700016 PM 1984329 ER PT J AU SCHAEFER, CM GREENE, R HALL, DA LINDEMANN, SR LLEWELLYN, HJ MCCARTHY, KA PILESPELLMAN, ER RUBENS, JR AF SCHAEFER, CM GREENE, R HALL, DA LINDEMANN, SR LLEWELLYN, HJ MCCARTHY, KA PILESPELLMAN, ER RUBENS, JR TI MEDIASTINAL ABNORMALITIES - DETECTION WITH STORAGE PHOSPHOR DIGITAL RADIOGRAPHY SO RADIOLOGY LA English DT Article DE IMAGES, PROCESSING; MEDIASTINUM, RADIOGRAPHY; RADIOGRAPHY, COMPARATIVE STUDIES; RADIOGRAPHY, DIGITAL; RADIOGRAPHY, STORAGE PHOSPHOR; RECEIVER OPERATING CHARACTERISTIC CURVE (ROC) ID CHEST RADIOGRAPHY; UNSHARP MASKING; ROC ANALYSIS; SYSTEM AB Conventional film radiography (FR) and six postprocessing algorithms of isodose storage phosphor digital radiography (SR) (0.2-mm x 10-bit pixel matrix) were compared in the evaluation of 40 mediastinal and 30 pulmonary lesions in 60 patients who underwent computed tomography of the chest. The six SR algorithms varied among each other in only one image parameter. One algorithm approximated conventional image characteristics. The other five algorithms were designed to optimize imaging of the mediastinum and tested the effects of gray-scale reversal, adjustment of optical density, a linear instead of a sigmoid gradation curve, and moderate edge enhancement of high and medium spatial frequencies. Performance was evaluated by calculating the average area under the receiver operating characteristic curve (A(z)) of 5,040 observations by six readers. Post-processing with high-frequency edge enhancement and density optimization for the mediastinum significantly improved performance of SR over FR in the detection of mediastinal lesions (A(z) = .80 +/- .02 vs .73 +/- .01, respectively). Gray-scale reversal significantly decreased performance (A(z) = .64 +/- .03). All SR algorithms that were postprocessed to optimize imaging of the mediastinum were significantly inferior to FR in the detection of pulmonary lesions. C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,32 FRUIT ST,BOSTON,MA 02114. HANOVER MED SCH,DEPT RADIOL 1,W-3000 HANNOVER 61,GERMANY. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 28 TC 36 Z9 36 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JAN PY 1991 VL 178 IS 1 BP 169 EP 173 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EP117 UT WOS:A1991EP11700031 PM 1984298 ER PT J AU CROWLEY, WF WHITCOMB, RW JAMESON, JL WEISS, J FINKELSTEIN, JS ODEA, LS AF CROWLEY, WF WHITCOMB, RW JAMESON, JL WEISS, J FINKELSTEIN, JS ODEA, LS TI NEUROENDOCRINE CONTROL OF HUMAN-REPRODUCTION IN THE MALE SO RECENT PROGRESS IN HORMONE RESEARCH LA English DT Review ID GONADOTROPIN-RELEASING HORMONE; FOLLICLE-STIMULATING-HORMONE; RAT PITUITARY-CELLS; GNRH-DEFICIENT MEN; LUTEINIZING-HORMONE; HYPOGONADOTROPIC HYPOGONADISM; INTERPULSE INTERVAL; LH-SECRETION; FREQUENCY; RESPONSES C1 MASSACHUSETTS GEN HOSP, THYROID UNIT, BOSTON, MA 02114 USA. MONTREAL GEN HOSP, DIV ENDOCRINOL & METAB, MONTREAL H3G 1A4, QUEBEC, CANADA. RP MASSACHUSETTS GEN HOSP, REPRODUCT ENDOCRINE UNITS, BOSTON, MA 02114 USA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0079-9963 J9 RECENT PROG HORM RES JI Recent Prog. Horm. Res. PY 1991 VL 47 BP 27 EP 67 PG 41 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA GV018 UT WOS:A1991GV01800003 ER PT B AU CROWLEY, WF WHITCOMB, RW JAMESON, JL WEISS, J FINKELSTEIN, JS ODEA, LS AF CROWLEY, WF WHITCOMB, RW JAMESON, JL WEISS, J FINKELSTEIN, JS ODEA, LS BE BARDIN, CW TI NEUROENDOCRINE CONTROL OF HUMAN-REPRODUCTION IN THE MALE SO RECENT PROGRESS IN HORMONE RESEARCH, VOL 47 SE RECENT PROGRESS IN HORMONE RESEARCH LA English DT Review CT 1990 MEETING OF THE LAURENTIAN HORMONE CONF CY AUG 27-30, 1990 CL COOPER MOUNTAIN, CO ID GONADOTROPIN-RELEASING HORMONE; FOLLICLE-STIMULATING-HORMONE; RAT PITUITARY-CELLS; GNRH-DEFICIENT MEN; LUTEINIZING-HORMONE; HYPOGONADOTROPIC HYPOGONADISM; INTERPULSE INTERVAL; LH-SECRETION; FREQUENCY; RESPONSES RP CROWLEY, WF (reprint author), MASSACHUSETTS GEN HOSP,REPRODUCT ENDOCRINE UNITS,BOSTON,MA 02114, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS INC PI SAN DIEGO PA SAN DIEGO BN 0-12-571147-6 J9 RECENT PROG HORM RES PY 1991 VL 47 BP 27 EP 67 PG 41 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA BU69U UT WOS:A1991BU69U00003 ER PT B AU BOEPPLE, PA MANSFIELD, MJ CRAWFORD, JD CRIGLER, JF BLIZZARD, RM CROWLEY, WF AF BOEPPLE, PA MANSFIELD, MJ CRAWFORD, JD CRIGLER, JF BLIZZARD, RM CROWLEY, WF BE NEGROVILAR, A PEREZPALACIOS, G TI USE OF GNRH ANALOGS AS THERAPEUTIC PROBES IN DEVELOPMENT - DIFFERENTIAL-EFFECTS OF SEX STEROIDS ON LINEAR GROWTH VS SKELETAL MATURATION IN CHILDREN WITH SEXUAL PRECOCITY SO REPRODUCTION, GROWTH AND DEVELOPMENT SE SERONO SYMPOSIA PUBLICATIONS FROM RAVEN PRESS LA English DT Proceedings Paper CT SCIENTIFIC MEETING ON REPRODUCTION, GROWTH AND DEVELOPMENT CY 1990 CL ACAPULCO, MEXICO SP ARES SERONO SYMP RP BOEPPLE, PA (reprint author), MASSACHUSETTS GEN HOSP,DEPT MED,REPROD UNIT,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU RAVEN PRESS PI NEW YORK PA NEW YORK BN 0-88167-650-0 J9 SERONO SYM PY 1991 VL 71 BP 91 EP 98 PG 8 WC Biochemistry & Molecular Biology; Developmental Biology; Endocrinology & Metabolism; Obstetrics & Gynecology; Pediatrics SC Biochemistry & Molecular Biology; Developmental Biology; Endocrinology & Metabolism; Obstetrics & Gynecology; Pediatrics GA BV29N UT WOS:A1991BV29N00011 ER PT J AU ROSE, SJ BURKE, JF BROCKHURST, RJ AF ROSE, SJ BURKE, JF BROCKHURST, RJ TI ARGON-LASER PHOTOABLATION OF A CHOROIDAL OSTEOMA SO RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES LA English DT Article AB Choroidal osteomas are rare, juxtapapillary choroidal tumors, which are usually unilateral but can be bilateral in as many as 30% of patients. Choroidal neovascularization may complicate this condition and be associated with severe visual loss. A patient treated with argon laser photocoagulation for SRNVM is described, and clinical and radiographic evidence of destruction of the osteoma during an 8-year followup is presented. The possible mechanisms of laser's ablative effect on bone, in addition to clinical application for choroidal osteoma treatment, are discussed. C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,DEPT OPHTHALMOL,BOSTON,MA 02114. NR 0 TC 17 Z9 21 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0275-004X J9 RETINA-J RET VIT DIS JI Retin.-J. Retin. Vitr. Dis. PY 1991 VL 11 IS 2 BP 224 EP 228 DI 10.1097/00006982-199111020-00007 PG 5 WC Ophthalmology SC Ophthalmology GA FZ028 UT WOS:A1991FZ02800007 PM 1925088 ER PT J AU RICE, LB CALDERWOOD, SB ELIOPOULOS, GM FARBER, BF KARCHMER, AW AF RICE, LB CALDERWOOD, SB ELIOPOULOS, GM FARBER, BF KARCHMER, AW TI ENTEROCOCCAL ENDOCARDITIS - A COMPARISON OF PROSTHETIC AND NATIVE VALVE DISEASE SO REVIEWS OF INFECTIOUS DISEASES LA English DT Review ID HIGH-LEVEL RESISTANCE; STREPTOCOCCUS-FAECALIS; GENTAMICIN; BACTEREMIA; DAPTOMYCIN; VANCOMYCIN; SYNERGISM; INFECTION; THERAPY; INVITRO AB Between 1973 and 1987, 36 patients with 41 episodes of enterococcal endocarditis were seen at our institution. There were 22 episodes of native valve endocarditis (NVE) and 19 episodes of prosthetic valve endocarditis (PVE). The overall mortality before completion of therapy was 15% (18% due to NVE and 11% due to PVE). Among patients with NVE, involvement of the aortic valve was significantly associated with death or complicated illness (defined as the need for valve replacement before completion of antibiotic therapy or relapse of endocarditis after completion of therapy). Among patients who survived episodes of PVE, 69% were cured without surgical intervention. Gentamicin was administered in combination with a penicillin or vancomycin in the majority of episodes (mean duration of therapy with aminoglycosides: 5 weeks). Renal dysfunction occurred in 44% of patients who received gentamicin and occurred more frequently in patients with elevated serum creatinine levels before treatment. Our results suggest that enterococcal PVE can often be successfully treated with antibiotics alone, and they confirm the efficacy of gentamicin when it is administered in combination with cell wall-active agents for the treatment of endocarditis due to enterococci that lack high-level resistance to this agent. C1 NEW ENGLAND DEACONESS HOSP,DEPT MED,INFECT DIS SECT,185 PILGRIM RD,BOSTON,MA 02215. MASSACHUSETTS GEN HOSP,DEPT MED,BOSTON,MA 02114. N SHORE UNIV HOSP,MANHASSET,NY 11030. NR 23 TC 55 Z9 56 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0162-0886 J9 REV INFECT DIS PD JAN-FEB PY 1991 VL 13 IS 1 BP 1 EP 7 PG 7 WC Immunology; Microbiology SC Immunology; Microbiology GA EU520 UT WOS:A1991EU52000001 PM 2017607 ER PT B AU WANG, CC AF WANG, CC BE VAETH, JM MEYER, JL TI INTRAORAL CONE FOR CARCINOMA OF THE ORAL CAVITY SO ROLE OF HIGH ENERGY ELECTRONS IN THE TREATMENT OF CANCER SE FRONTIERS OF RADIATION THERAPY AND ONCOLOGY LA English DT Proceedings Paper CT 25TH ANNUAL SAN FRANCISCO CANCER SYMP : THE ROLE OF HIGH ENERGY ELECTRONS IN THE TREATMENT OF CANCER CY FEB 09-11, 1990 CL SAN FRANCISCO, CA SP ST MARYS FDN, CLINITHERM, COMP MED SYST, GAMMEX LASERS, GE MED SYST, HAYNES RADIAT, HUESTIS MACHINE, LACLEDE PROFESSIONAL PROD, MARXPLAN COMP SYST, MEDI CALIBRAT RP WANG, CC (reprint author), MASSACHUSETTS GEN HOSP,CTR CANC,DEPT RADIAT MED,BOSTON,MA 02114, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU KARGER PI BASEL PA BASEL BN 3-8055-5235-1 J9 FRONT RADIAT THER ON JI Front.Radiat.Ther.Oncol. PY 1991 VL 25 BP 128 EP 131 PG 4 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA BT33D UT WOS:A1991BT33D00010 PM 1908406 ER PT J AU CRAIG, WA MCDONALD, P AF CRAIG, WA MCDONALD, P TI ANTIBIOTIC PHARMACOKINETICS, UPTAKE BY BACTERIA AND INTERACTION WITH PHAGOCYTOSIS - DISCUSSION OF SESSION-I SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Discussion RP CRAIG, WA (reprint author), WILLIAM S MIDDLETON MEM VET ADM MED CTR,2500 OVERLOOK TERRACE,MADISON,WI 53705, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 SU 74 BP 58 EP 59 PG 2 WC Infectious Diseases SC Infectious Diseases GA EZ469 UT WOS:A1991EZ46900008 ER PT J AU CRAIG, WA EBERT, SC AF CRAIG, WA EBERT, SC TI KILLING AND REGROWTH OF BACTERIA INVITRO - A REVIEW SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT SYMP ON PHARMACODYNAMICS OF ANTIBIOTICS : CONSEQUENCES FOR DOSING CY JUL 07-09, 1990 CL STOCKHOLM, SWEDEN SP ASTRA INFECT ID PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; MODEL; ANTIBIOTICS; AMPICILLIN; IMIPENEM; CIPROFLOXACIN; INTERMITTENT AB Minimum inhibitory and bactericidal concentrations do not describe the time course of a drug's antimicrobial activity against bacteria. Some antimicrobials exhibit concentration dependent killing over a wide range of concentrations (e.g. aminoglycosides and quinolones), while others show maximal killing at concentrations near the MIC (e.g. beta-lactams and glycopeptides). The aminoglycosides and quinolones can require high drug concentrations (about 10-fold higher than the MIC) to prevent the selection of resistant subpopulations of bacteria. Persistent suppression of bacterial growth after antimicrobial exposure is called the 'postantibiotic effect' (PAE) and varies in duration depending on the drug-organism combination, as well as the concentration and duration of drug exposure. Antimicrobials which are inhibitors of protein and nucleic acid synthesis exhibit prolonged PAEs with a large variety of bacteria. While beta-lactam antibiotics demonstrate PAEs with Gram-positive cocci, very short or no PAEs are observed with these drugs with Gram-negative bacilli. The only exception is that penem antibiotics can induce PAEs with some strains of Gram-negative bacilli, primarily Pseudomonas aeruginosa. Thus, the pharmacodynamic activity of an antimicrobial can vary markedly depending on the microorganism and the class of drug and its concentration. C1 UNIV WISCONSIN,DEPT MED,MADISON,WI 53706. UNIV WISCONSIN,SCH PHARM,MADISON,WI 53706. RP CRAIG, WA (reprint author), WILLIAM S MIDDLETON MEM VET ADM MED CTR,2500 OVERLOOK TERRACE,MADISON,WI 53705, USA. NR 39 TC 3 Z9 4 U1 2 U2 2 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 SU 74 BP 63 EP 70 PG 8 WC Infectious Diseases SC Infectious Diseases GA EZ469 UT WOS:A1991EZ46900009 ER PT J AU LEGGETT, JE EBERT, S FANTIN, B CRAIG, WA AF LEGGETT, JE EBERT, S FANTIN, B CRAIG, WA TI COMPARATIVE DOSE-EFFECT RELATIONS AT SEVERAL DOSING INTERVALS FOR BETA-LACTAM, AMINOGLYCOSIDE AND QUINOLONE ANTIBIOTICS AGAINST GRAM-NEGATIVE BACILLI IN MURINE THIGH-INFECTION AND PNEUMONITIS MODELS SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT SYMP ON PHARMACODYNAMICS OF ANTIBIOTICS : CONSEQUENCES FOR DOSING CY JUL 07-09, 1990 CL STOCKHOLM, SWEDEN SP ASTRA INFECT ID KLEBSIELLA-PNEUMONIAE; COMPARATIVE EFFICACY; TOBRAMYCIN; MICE; GENTAMICIN AB Relatively few animal studies have investigated the influence of dosing regimens on the efficacy of antibiotics possessing different pharmacodynamic characteristics. We evaluated the impact of dosing interval on the relative efficacy and potency of beta-lactams, aminoglycosides, and ciprofloxacin against Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae in murine pneumonitis and thigh-infection models. We used a sigmoid dose-response model to determine the maximal bactericidal effect at 24 hours (E(max)) and the total dose required to achieve 50% of E(max) (P50) at several dosing intervals. P50S (a measure of drug potency, in mg/kg/day) for beta-lactams increased 14- to 73-fold with longer intervals in both models. Dosing interval had little impact on P50S for aminoglycosides or ciprofloxacin. E(max) varied among drugs but displayed no dependence on dosing interval. This method of analysis allows comparison of efficacy and dependence of potency on dosing regimen among different classes of antibiotics. C1 WILLIAM S MIDDLETON MEM VET ADM MED CTR,DEPT MED,MADISON,WI 53705. WILLIAM S MIDDLETON MEM VET ADM MED CTR,SCH PHARM,MADISON,WI 53705. UNIV WISCONSIN,MADISON,WI 53706. NR 13 TC 0 Z9 2 U1 1 U2 5 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 SU 74 BP 179 EP 184 PG 6 WC Infectious Diseases SC Infectious Diseases GA EZ469 UT WOS:A1991EZ46900025 ER PT J AU CARS, O CRAIG, WA AF CARS, O CRAIG, WA TI PHARMACODYNAMICS OF ANTIBIOTICS - CONSEQUENCES FOR DOSING IN PATIENTS - DISCUSSION OF SESSION-IV SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Discussion C1 WILLIAM S MIDDLETON MEM VET ADM MED CTR,MADISON,WI 53705. RP CARS, O (reprint author), UNIV HOSP UPPSALA,DEPT INFECT DIS,S-75185 UPPSALA,SWEDEN. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 SU 74 BP 280 EP 281 PG 2 WC Infectious Diseases SC Infectious Diseases GA EZ469 UT WOS:A1991EZ46900038 ER PT J AU CARS, O CRAIG, WA AF CARS, O CRAIG, WA TI GENERAL DISCUSSION ON ANTIBIOTIC DOSING SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Discussion C1 WILLIAM S MIDDLETON MEM VET ADM MED CTR,MADISON,WI 53705. RP CARS, O (reprint author), UNIV HOSP UPPSALA,DEPT INFECT DIS,S-75185 UPPSALA,SWEDEN. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 SU 74 BP 282 EP 283 PG 2 WC Infectious Diseases SC Infectious Diseases GA EZ469 UT WOS:A1991EZ46900039 ER PT J AU CRAIG, WA AF CRAIG, WA TI PHARMACODYNAMICS OF ANTIBIOTICS-CONSEQUENCES FOR DOSING - PROCEEDINGS OF A SYMPOSIUM HELD IN STOCKHOLM, JUNE 7-9, 1990 - SUMMARY AND FUTURE-DIRECTIONS SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material RP CRAIG, WA (reprint author), WILLIAM S MIDDLETON MEM VET ADM MED CTR,2500 OVERLOOK TERRACE,MADISON,WI 53705, USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 SU 74 BP 284 EP 286 PG 3 WC Infectious Diseases SC Infectious Diseases GA EZ469 UT WOS:A1991EZ46900040 ER PT J AU DELIA, JA WEINRAUCH, LA AF DELIA, JA WEINRAUCH, LA TI HOW CAN THE CARE OF DIABETIC ESRD PATIENTS BE IMPROVED SO SEMINARS IN DIALYSIS LA English DT Editorial Material RP DELIA, JA (reprint author), JOSLIN DIABET CTR,JOHN COOK RENAL UNIT,ONE JOSLIN PL,BOSTON,MA 02215, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0894-0959 J9 SEMIN DIALYSIS JI Semin. Dial. PD JAN-MAR PY 1991 VL 4 IS 1 BP 16 EP 18 DI 10.1111/j.1525-139X.1991.tb00404.x PG 3 WC Urology & Nephrology SC Urology & Nephrology GA EZ352 UT WOS:A1991EZ35200006 ER PT J AU PATHAK, MA AF PATHAK, MA TI ULTRAVIOLET-RADIATION AND THE DEVELOPMENT OF NONMELANOMA AND MELANOMA SKIN-CANCER - CLINICAL AND EXPERIMENTAL-EVIDENCE SO SKIN PHARMACOLOGY LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON MAST CELL / 7TH ANNUAL SYMP ON THE SKIN PHARMACOLOGY SOC : IMMUNOPHARMACOLOGY AND CARCINOGENESIS CY OCT 30-31, 1990 CL HIROSHIMA, JAPAN SP SKIN PHARMACOL SOC DE ULTRAVIOLET RADIATION; MELANOMA; BASAL AND SQUAMOUS CELL CARCINOMAS; SUNLIGHT; HAIRLESS MICE; LYMPHOMAS; INDUCTION OF MELANOMA; DMBA ID INDUCED MALIGNANT-MELANOMA; EXPOSURE; SUNLIGHT; NAEVI; MICE; SUN AB Clinical and experimental evidence explaining and supporting the role of UV radiation as a causal factor for the induction and promotion of nonmelanoma and malignant melanoma skin cancer are presented. While there is excellent animal experimental data and human epidemiologic evidence supporting the causal relationship of UVR (UVB, as well as UVA radiation) for basal and squamous cell carcinomas, the data establishing a direct causal relationship between melanoma and exposure to sunlight appear to be complex. They do, however, suggest a definite promotional role of sunlight in the causation of melanoma. Using a hairless pigmented mouse strain (Skh-hr2), experiments were initiated to examine the role of UVR in the induction of melanoma. A single application of DMBA as an initiator and subsequent thrice-weekly exposures to either UVB (290-320 nm) or UVA (320-400 nm) or the combined exposures of UVA and UVB resulted in the formation of blue nevus-like lesions. Repeated UVR exposures for over 30 weeks resulted in the development of melanoma (38 %), as well as lymphoma and squamous cell carcinoma only in those mice that were pretreated with DMBA and had developed nevi. Mice receiving UVB, UVA, or the combination treatments of UVB plus UVA without DMBA pretreatment developed papillomas and squamous cell carcinoma but no melanoma. These studies indicate that some initiation event is essential to transform melanocytes to blue nevus-like lesions before UVR (UVB + UVA) can act as a promoter and accelerate the development of malignant melanoma, as well as lymphoma. RP PATHAK, MA (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT DERMATOL,BOSTON,MA 02114, USA. FU NCI NIH HHS [5-R01-CA-05003-31] NR 42 TC 52 Z9 52 U1 0 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1011-0283 J9 SKIN PHARMACOL JI Skin Pharmacol. PY 1991 VL 4 SU 1 BP 85 EP 94 PG 10 WC Dermatology; Pharmacology & Pharmacy SC Dermatology; Pharmacology & Pharmacy GA GR551 UT WOS:A1991GR55100011 PM 1764252 ER PT J AU ENGDAHL, BE PAGE, WF MILLER, TW AF ENGDAHL, BE PAGE, WF MILLER, TW TI AGE, EDUCATION, MALTREATMENT, AND SOCIAL SUPPORT AS PREDICTORS OF CHRONIC DEPRESSION IN FORMER PRISONERS OF WAR SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY LA English DT Article ID PSYCHIATRIC-ILLNESS; FOLLOW-UP; STRESS DISORDER; PREVALENCE; SYMPTOMS; VETERANS; RELEASE; SCALE C1 US DEPT VETERANS AFFAIRS,MED CTR,LEXINGTON,KY. UNIV MINNESOTA,DEPT PSYCHOL,MINNEAPOLIS,MN 55455. NATL ACAD SCI,INST MED,MED FOLLOW UP AGCY,WASHINGTON,DC 20418. UNIV KENTUCKY,DEPT PSYCHIAT,LEXINGTON,KY 40506. RP ENGDAHL, BE (reprint author), US DEPT VET AFFAIRS,MED CTR 116B,MINNEAPOLIS,MN 55417, USA. OI Engdahl, Brian/0000-0001-5436-457X NR 29 TC 27 Z9 27 U1 1 U2 2 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0933-7954 J9 SOC PSYCH PSYCH EPID JI Soc. Psychiatry Psychiatr. Epidemiol. PY 1991 VL 26 IS 2 BP 63 EP 67 DI 10.1007/BF00791528 PG 5 WC Psychiatry SC Psychiatry GA FE814 UT WOS:A1991FE81400002 PM 2047905 ER PT J AU BERKMAN, B MILLAR, S HOLMES, W BONANDER, E AF BERKMAN, B MILLAR, S HOLMES, W BONANDER, E TI PREDICTING ELDERLY CARDIAC PATIENTS AT RISK FOR READMISSION SO SOCIAL WORK IN HEALTH CARE LA English DT Article ID MYOCARDIAL-INFARCTION; INTERVENTION; SURGERY AB Elder patients with cardiac disease are at high risk for physical deterioration during post hospital recovery and suffer frequent early readmission. It is important to identify such patients who frequently need help with discharge planning from social workers during their first admission. This study utilized computerized data on 628 patients, 238 of whom were readmissions. Question was raised as to what factors (functional, psychological, social and environmental), differentiated patients who were readmitted from those who were not. Using logistic regression, three variables: marital status, presence of coping difficulty and age of patients were identified as predictors of readmission within three months. Those who were married were less likely to be readmitted. Those with coping difficulties and older individuals were more likely to be readmitted. The accuracy of prediction, using these three factors, was 61 percent. Of those patients predicted as not being readmitted, sixty-nine percent were correctly predicted, while 39 percent were readmitted. Of patients predicted as readmissions, 49 percent were correctly predicted, while 51 percent were not. The major limitation of this study was that key physiological determinants of readmission were not collected. It is imperative that a valid screening device for predicting who is at risk for readmission should include physiological preconditions as well as functional and psychosocial data. C1 COMMONWEALTH MASSACHUSETTS,CTR STAT ANAL,BOSTON,MA. RP BERKMAN, B (reprint author), MASSACHUSETTS GEN HOSP,DEPT SOCIAL SERV,BOSTON,MA 02114, USA. NR 22 TC 22 Z9 22 U1 1 U2 1 PU HAWORTH PRESS INC PI BINGHAMTON PA 10 ALICE ST, BINGHAMTON, NY 13904-1580 SN 0098-1389 J9 SOC WORK HEALTH CARE JI Soc. Work Health Care PY 1991 VL 16 IS 1 BP 21 EP 38 PG 18 WC Social Work SC Social Work GA HH778 UT WOS:A1991HH77800003 PM 1796339 ER PT J AU MULLINS, LL LYNCH, J ORTEN, J YOULL, LK AF MULLINS, LL LYNCH, J ORTEN, J YOULL, LK TI DEVELOPING A PROGRAM TO ASSIST TURNERS SYNDROME PATIENTS AND FAMILIES SO SOCIAL WORK IN HEALTH CARE LA English DT Article ID BEHAVIOR PROBLEMS; CHILDREN AB Turner's Syndrome [TS] is a chromosomal disorder that affects one in 2500 women. It results in an array of physical difficulties, including short stature, lack of secondary sexual development and cognitive problems. Little research exists to document the psychosocial problems and needs of individuals with TS and their families. The current literature and the results of a regionally based needs assessment are reviewed to guide program development, with emphasis on the emotional and informational needs of these families. Suggestions are provided for strategic early communication and information sharing, development of skill-specific support groups, family networks and family therapy. C1 UNIV OKLAHOMA,COUNSELING PSYCHOL,NORMAN,OK 73019. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. CHILDRENS HOSP OKLAHOMA,DEPT SOCIAL WORK,OKLAHOMA CITY,OK. RP MULLINS, LL (reprint author), UNIV OKLAHOMA,HLTH SCI CTR,DEPT PSYCHIAT & BEHAV SCI,OKLAHOMA CITY,OK 73190, USA. NR 21 TC 5 Z9 5 U1 1 U2 1 PU HAWORTH PRESS INC PI BINGHAMTON PA 10 ALICE ST, BINGHAMTON, NY 13904-1580 SN 0098-1389 J9 SOC WORK HEALTH CARE JI Soc. Work Health Care PY 1991 VL 16 IS 2 BP 69 EP 79 PG 11 WC Social Work SC Social Work GA HM264 UT WOS:A1991HM26400006 PM 1667047 ER PT J AU WHALEY, WL BATES, GP NOVELLETTO, A SEDLACEK, Z CHENG, S ROMANO, D ORMONDROYD, E ALLITTO, B LIN, C YOUNGMAN, S BAXENDALE, S BUCAN, M ALTHERR, M WASMUTH, J WEXLER, NS FRONTALI, M FRISCHAUF, AM LEHRACH, H MACDONALD, ME GUSELLA, JF AF WHALEY, WL BATES, GP NOVELLETTO, A SEDLACEK, Z CHENG, S ROMANO, D ORMONDROYD, E ALLITTO, B LIN, C YOUNGMAN, S BAXENDALE, S BUCAN, M ALTHERR, M WASMUTH, J WEXLER, NS FRONTALI, M FRISCHAUF, AM LEHRACH, H MACDONALD, ME GUSELLA, JF TI MAPPING OF COSMID CLONES IN HUNTINGTONS-DISEASE REGION OF CHROMOSOME-4 SO SOMATIC CELL AND MOLECULAR GENETICS LA English DT Article ID PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE; INSITU HYBRIDIZATION; MAMMALIAN-CELLS; DNA MARKERS; D4S10 LOCUS; G8 D4S10; GENE; LOCALIZATION; RECOMBINATION; POLYMORPHISM AB Huntington's disease (HD) is tightly linked to genetic markers in 4p16.3. We have used a regional somatic cell hybrid mapping panel to isolate and map 25 cosmids to the proximal portion of 4p16.3 and 17 cosmids to the distal portion. The latter were positioned by long-range restriction mapping relative to previously mapped markers. One cosmid, L6 (D4S166), spans the critical breakpoint in the mapping panel that distinguishes proximal and distal 4p16.3. Four of the cosmids mapped distal to D4S90, the previous terminal marker on 4p, and stretched to within 75 kb of the telomere. Several of the cosmids that mapped between L6 and D4S90 were clustered near a number of previously isolated clones in a region with many NotI sites. Cosmid E4 (D4S168) was localized immediately proximal to the one remaining gap in the long-range restriction map of distal 4p16.3. Although pulsed field gel mapping with E4 failed to link the two segments of the map, the intervening gap was excluded as a potential site for the HD gene by genetic analysis. C1 IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND. UNIV TOR VERGATA,DIPARTIMENTO BIOL,ROME,ITALY. COLUMBIA UNIV,DEPT NEUROL,NEW YORK,NY 10032. HEREDITARY DIS FDN,SANTA MONICA,CA 90401. HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02114. UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717. CNR,IST MED SPERIMENTALE,ROME,ITALY. RP WHALEY, WL (reprint author), MASSACHUSETTS GEN HOSP,NEUROGENET LAB,BOSTON,MA 02114, USA. RI Bates, Gillian/E-1146-2012; OI Bates, Gillian/0000-0002-4041-6305; Novelletto, Andrea/0000-0002-1146-7680 FU NINDS NIH HHS [NS16367, NS20012, NS22031] NR 32 TC 50 Z9 50 U1 1 U2 4 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0740-7750 J9 SOMAT CELL MOLEC GEN JI Somat.Cell Mol.Genet. PD JAN PY 1991 VL 17 IS 1 BP 83 EP 91 DI 10.1007/BF01233207 PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity GA FA370 UT WOS:A1991FA37000007 PM 1671801 ER PT J AU FINBERG, RW AF FINBERG, RW TI HEAT-SHOCK PROTEINS, AND GAMMA-ALPHA-DELTA T-CELLS SO SPRINGER SEMINARS IN IMMUNOPATHOLOGY LA English DT Article ID MYCOBACTERIUM-TUBERCULOSIS; LYMPHOCYTES-T; ANTIGEN; REACTIVITY; HOMOLOGY; DISEASE; CLONES; GENES RP FINBERG, RW (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,INFECT DIS LAB,BOSTON,MA 02115, USA. RI Finberg, Robert/E-3323-2010 NR 39 TC 5 Z9 6 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0344-4325 J9 SPRINGER SEMIN IMMUN JI Springer Semin. Immunopathol. PY 1991 VL 13 IS 1 BP 55 EP 62 DI 10.1007/BF01225278 PG 8 WC Immunology; Pathology SC Immunology; Pathology GA GM124 UT WOS:A1991GM12400005 PM 1837960 ER PT J AU ADAMS, RD AF ADAMS, RD TI THE NEUROPATHOLOGY OF RADIOSURGERY SO STEREOTACTIC AND FUNCTIONAL NEUROSURGERY LA English DT Article; Proceedings Paper CT HARVARD RADIOSURGERY UPDATE COURSE ON RADIOSURGERY : ENHANCEMENT OF CLINICAL EXCELLENCE CY JUN 11-13, 1990 CL BOSTON, MA DE STEREOTAXIC RADIOSURGERY; RADIOSURGERY; PATHOLOGY; RADIATION LESION C1 MASSACHUSETTS GEN HOSP,NEUROL SERV,BOSTON,MA 02114. RP ADAMS, RD (reprint author), HARVARD UNIV,SCH MED,BOSTON,MA 02115, USA. NR 7 TC 9 Z9 10 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1011-6125 J9 STEREOT FUNCT NEUROS JI Stereotact. Funct. Neurosurg. PY 1991 VL 57 IS 1-2 BP 82 EP 86 DI 10.1159/000099558 PG 5 WC Neurosciences; Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA HG992 UT WOS:A1991HG99200009 PM 1808658 ER PT J AU UEMURA, Y KOWALL, NW MOSKOWITZ, MA AF UEMURA, Y KOWALL, NW MOSKOWITZ, MA TI TIME COURSE AND DISTRIBUTION OF C-FOS PROTEIN-LIKE IMMUNOREACTIVITY (CFPLI) INDUCED BY FOCAL CEREBRAL-ISCHEMIA IN RATS SO STROKE LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. RI Kowall, Neil/G-6364-2012 OI Kowall, Neil/0000-0002-6624-0213 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0039-2499 J9 STROKE JI Stroke PD JAN PY 1991 VL 22 IS 1 BP 132 EP 132 PG 1 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA ET895 UT WOS:A1991ET89500047 ER PT J AU YOKOTA, M KANO, M KOKETSU, N MOSKOWITZ, MA AF YOKOTA, M KANO, M KOKETSU, N MOSKOWITZ, MA TI PARASYMPATHETIC DENERVATION OF RAT PIAL VESSELS INCREASES INFARCTION SIZE AFTER MCA OCCLUSION IN 2 RAT MODELS SO STROKE LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0039-2499 J9 STROKE JI Stroke PD JAN PY 1991 VL 22 IS 1 BP 140 EP 140 PG 1 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA ET895 UT WOS:A1991ET89500080 ER PT B AU AOBA, T MORENO, EC AF AOBA, T MORENO, EC BE SIKES, CS WHEELER, AP TI STRUCTURAL RELATIONSHIP OF AMELOGENIN PROTEINS TO THEIR REGULATORY FUNCTION OF ENAMEL MINERALIZATION SO SURFACE REACTIVE PEPTIDES AND POLYMERS: DISCOVERY AND COMMERCIALIZATION SE ACS SYMPOSIUM SERIES LA English DT Proceedings Paper CT SYMP AT THE 197TH NATIONAL MEETING OF THE AMERICAN CHEMICAL SOC - SURFACE REACTIVE PEPTIDES AND POLYMERS : DISCOVERY AND COMMERCIALIZATION CY APR 12-13, 1989 CL DALLAS, TX SP AMER CHEM SOC, DIV IND & ENGN CHEM ID DEVELOPING BOVINE ENAMEL; APATITE CRYSTAL-GROWTH; AMINO-TERMINAL SEGMENT; PROLINE-RICH PROTEINS; DENTAL ENAMEL; MATRIX PROTEINS; BIOLOGICAL INTEREST; PROTEOLYTIC-ENZYME; CALCIUM APATITES; ACID-SEQUENCE RP AOBA, T (reprint author), FORSYTH DENT CTR,140 FENWAY,BOSTON,MA 02115, USA. NR 0 TC 14 Z9 15 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA WASHINGTON BN 0-8412-1886-2 J9 ACS SYM SER PY 1991 VL 444 BP 85 EP 106 PG 22 WC Biochemistry & Molecular Biology; Chemistry, Applied SC Biochemistry & Molecular Biology; Chemistry GA BS51H UT WOS:A1991BS51H00007 ER PT B AU TARR, GE PAXTON, RJ PAN, YCE ERICSSON, LH CRABB, JW AF TARR, GE PAXTON, RJ PAN, YCE ERICSSON, LH CRABB, JW BE VILLAFRANCA, JJ TI AMINO-ACID-ANALYSIS 1990 - THE 3RD COLLABORATIVE STUDY FROM THE ASSOCIATION OF BIOMOLECULAR RESOURCE FACILITIES (ABRF) SO TECHNIQUES IN PROTEIN CHEMISTRY II LA English DT Proceedings Paper CT 4TH ANNUAL SYMP OF THE PROTEIN SOC CY AUG 11-15, 1990 CL SAN DIEGO, CA SP PROTEIN SOC, A A A LAB, APPL BIOSYST, A V I V ASSOC, BECKMAN INSTRUMENTS, BIOSYM TECHNOL, BRISTOL MYERS SQUIBB PHARM RES INST, DUPONT CO, ELI LILLY & CO, FINNIGAN RP TARR, GE (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC PI SAN DIEGO PA SAN DIEGO BN 0-12-721957-9 PY 1991 BP 139 EP 150 PG 12 WC Biochemistry & Molecular Biology; Medical Laboratory Technology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Medical Laboratory Technology; Research & Experimental Medicine GA BT33C UT WOS:A1991BT33C00013 ER PT J AU MCPEEK, B AF MCPEEK, B TI INTUITION AS A STRATEGY OF MEDICAL DECISION-MAKING - DISCUSSION ABOUT INTUITION IN SURGERY AS A STRATEGY OF MEDICAL DECISION-MAKING - ITS POTENCY AND LIMITATIONS SO THEORETICAL SURGERY LA English DT Discussion DE INTUITION; DECISION MAKING; CLINICAL COMPETENCE RP MCPEEK, B (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT ANESTHESIA,BOSTON,MA 02114, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0179-8669 J9 THEOR SURG JI Theor. Surg. PY 1991 VL 6 IS 2 BP 83 EP 84 PG 2 WC Surgery SC Surgery GA FG316 UT WOS:A1991FG31600008 ER PT B AU GREENE, R SCHAEFER, CM OLIVER, LC DEMENT, J LILIS, R FINKELSTEIN, M GAMSU, G MARKOVITZ, A CASE, B SELIKOFF, IJ KRONENBERG, R ERNST, P AF GREENE, R SCHAEFER, CM OLIVER, LC DEMENT, J LILIS, R FINKELSTEIN, M GAMSU, G MARKOVITZ, A CASE, B SELIKOFF, IJ KRONENBERG, R ERNST, P BE LANDRIGAN, PJ KAZEMI, H TI IMPROVED DETECTION OF ASBESTOS-RELATED PLEURAL PLAQUES WITH DIGITAL RADIOGRAPHY SO THIRD WAVE OF ASBESTOS DISEASE : EXPOSURE TO ASBESTOS IN PLACE: PUBLIC HEALTH CONTROL SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON THE THIRD WAVE OF ASBESTOS DISEASE - EXPOSURE TO PLACE : PUBLIC HEALTH CONTROL CY JUN 07-09, 1990 CL NEW YORK, NY RP GREENE, R (reprint author), MASSACHUSETTS GEN HOSP,DEPT OCCUPAT MED,BOSTON,MA 02114, USA. NR 0 TC 1 Z9 2 U1 0 U2 2 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-678-X J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 643 BP 90 EP 99 DI 10.1111/j.1749-6632.1991.tb24448.x PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA BW42W UT WOS:A1991BW42W00008 PM 1809179 ER PT B AU MARK, EJ YOKOI, T AF MARK, EJ YOKOI, T BE LANDRIGAN, PJ KAZEMI, H TI ABSENCE OF EVIDENCE FOR A SIGNIFICANT BACKGROUND INCIDENCE OF DIFFUSE MALIGNANT MESOTHELIOMA APART FROM ASBESTOS EXPOSURE SO THIRD WAVE OF ASBESTOS DISEASE : EXPOSURE TO ASBESTOS IN PLACE: PUBLIC HEALTH CONTROL SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON THE THIRD WAVE OF ASBESTOS DISEASE - EXPOSURE TO PLACE : PUBLIC HEALTH CONTROL CY JUN 07-09, 1990 CL NEW YORK, NY RP MARK, EJ (reprint author), MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114, USA. NR 0 TC 21 Z9 21 U1 1 U2 2 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-678-X J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 643 BP 196 EP 204 DI 10.1111/j.1749-6632.1991.tb24463.x PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA BW42W UT WOS:A1991BW42W00019 PM 1809132 ER PT B AU OLIVER, LC SPRINCE, NL GREENE, R AF OLIVER, LC SPRINCE, NL GREENE, R BE LANDRIGAN, PJ KAZEMI, H TI ASBESTOS-RELATED ABNORMALITIES IN SCHOOL MAINTENANCE PERSONNEL SO THIRD WAVE OF ASBESTOS DISEASE : EXPOSURE TO ASBESTOS IN PLACE: PUBLIC HEALTH CONTROL SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON THE THIRD WAVE OF ASBESTOS DISEASE - EXPOSURE TO PLACE : PUBLIC HEALTH CONTROL CY JUN 07-09, 1990 CL NEW YORK, NY RP OLIVER, LC (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,MED SERV,PULM & CRIT CARE UNIT,BOSTON,MA 02114, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-678-X J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 643 BP 521 EP 529 DI 10.1111/j.1749-6632.1991.tb24503.x PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA BW42W UT WOS:A1991BW42W00051 PM 1809165 ER PT J AU ANDERSON, KC GORGONE, BC WAHLERS, E COOK, J BARRETT, B ANDERSEN, J AF ANDERSON, KC GORGONE, BC WAHLERS, E COOK, J BARRETT, B ANDERSEN, J TI PREPARATION AND UTILIZATION OF LEUKOCYTE POOR APHERESIS PLATELETS SO TRANSFUSION SCIENCE LA English DT Article AB Efficiency of collection of apheresis platelets was found to be equivalent (approximately 50%) with the COBE 2997, the Fenwal CS3000, Haemonetics V50 or COBE Spectra(TM) cell separators. A minor fraction (1.5-3.5%) of 6466 consecutive transfusions of apheresis platelets were complicated by febrile transfusion reactions (FTRs). There was a 12.1% incidence of second FTRs following an initial reaction. Centrifugation, filtration, or the provision of platelets harvested on the COBE Spectra(TM) reduced the incidence of subsequent FTRs to less-than-or-equal-to 3.1% in patients with two prior FTRs. Leukocyte content in apheresis platelets ranged from 5 x 10(5) in COBE Spectra(TM) apheresis platelets to 10(9) in platelets from the Fenwal CS3000 or COBE 2997. Filtered platelets from the Haemonetics V50 were as leukopoor as COBE Spectra(TM) apheresis platelets, but centrifugation or filtration of other apheresis platelets did not achieve equivalent leukodepletion. These results suggest that (1) FTRs are rare after transfusion of apheresis platelets; and (2) provision of either platelets from the COBE Spectra(TM) or other apheresis platelets which have been centrifuged or filtered can avoid FTRs in the majority of patients with a history of repeated prior reactions. RP ANDERSON, KC (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,44 BINNEY ST,BOSTON,MA 02115, USA. NR 0 TC 10 Z9 10 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0955-3886 J9 TRANSFUS SCI JI Transfus. Sci. PY 1991 VL 12 IS 3 BP 163 EP 170 DI 10.1016/0955-3886(91)90125-M PG 8 WC Hematology SC Hematology GA GB259 UT WOS:A1991GB25900010 ER PT J AU ANDERSON, KC AF ANDERSON, KC TI TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE - WHO IS AT RISK SO TRANSFUSION SCIENCE LA English DT Article AB This issue marks the beginning of a new section in Transfusion-Science entitled "Evolving Concepts in Transfusion Medicine." This section is designed to feature critical discussions (2 pages or less) of evolving areas within transfusion medicine. It is meant to highlight new developments and areas of controversy within the broad scope of the medical, scientific, technical, epidemiologic, and public health aspects relating to the rationale for provision of blood component therapy. Recent and continued advances in our understanding of the biology of hematopoiesis, infectious diseases, and molecular genetics now provide the scientific basis for an evolution of our principles and practices within transfusion medicine. Ongoing technical advances, i.e. more effective leuko-depletion methods and recombinant techniques, will make it possible to provide new components for transfusion. New sensitive and specific techniques for the detection of infectious disease, i.e. polymerase chain reaction technology, may have broad impact on the safety of transfusion. It is the goal of "Evolving Concepts in Transfusion Medicine" to relate these and other new research findings to their current and future impact on transfusion practice. RP ANDERSON, KC (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV MED,44 BINNEY ST,BOSTON,MA 02115, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0955-3886 J9 TRANSFUS SCI JI Transfus. Sci. PY 1991 VL 12 IS 4 BP 277 EP 279 DI 10.1016/0955-3886(91)90107-E PG 3 WC Hematology SC Hematology GA GL013 UT WOS:A1991GL01300009 ER PT B AU FITZPATRICK, TB AF FITZPATRICK, TB BE JOHNSON, WG GOMEZ, MR TI HISTORY AND SIGNIFICANCE OF WHITE MACULES, EARLIEST VISIBLE SIGN OF TUBEROUS SCLEROSIS SO TUBEROUS SCLEROSIS AND ALLIED DISORDERS: CLINICAL, CELLULAR, AND MOLECULAR STUDIES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON TUBEROUS SCLEROSIS AND ALLIED DISORDERS CY APR 23-25, 1990 CL BETHESDA, MD SP NEW YORK ACAD SCI, NATL TUBEROUS SCLEROSIS ASSOC, NINDS, PARKE DAVIS RP FITZPATRICK, TB (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,BOSTON,MA 02114, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-656-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 615 BP 26 EP 35 PG 10 WC Behavioral Sciences; Genetics & Heredity; Neurosciences; Pathology SC Behavioral Sciences; Genetics & Heredity; Neurosciences & Neurology; Pathology GA BT82C UT WOS:A1991BT82C00004 ER PT B AU RICHARDSON, EP AF RICHARDSON, EP BE JOHNSON, WG GOMEZ, MR TI PATHOLOGY OF TUBEROUS SCLEROSIS - NEUROPATHOLOGIC ASPECTS SO TUBEROUS SCLEROSIS AND ALLIED DISORDERS: CLINICAL, CELLULAR, AND MOLECULAR STUDIES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON TUBEROUS SCLEROSIS AND ALLIED DISORDERS CY APR 23-25, 1990 CL BETHESDA, MD SP NEW YORK ACAD SCI, NATL TUBEROUS SCLEROSIS ASSOC, NINDS, PARKE DAVIS RP RICHARDSON, EP (reprint author), MASSACHUSETTS GEN HOSP,CHARLES S KUBIK LAB NEUROPATHOL,BOSTON,MA 02114, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-656-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 615 BP 128 EP 139 PG 12 WC Behavioral Sciences; Genetics & Heredity; Neurosciences; Pathology SC Behavioral Sciences; Genetics & Heredity; Neurosciences & Neurology; Pathology GA BT82C UT WOS:A1991BT82C00014 ER PT B AU CAVINESS, VS TAKAHASHI, T AF CAVINESS, VS TAKAHASHI, T BE JOHNSON, WG GOMEZ, MR TI CEREBRAL-LESIONS OF TUBEROUS SCLEROSIS IN RELATION TO NORMAL HISTOGENESIS SO TUBEROUS SCLEROSIS AND ALLIED DISORDERS: CLINICAL, CELLULAR, AND MOLECULAR STUDIES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON TUBEROUS SCLEROSIS AND ALLIED DISORDERS CY APR 23-25, 1990 CL BETHESDA, MD SP NEW YORK ACAD SCI, NATL TUBEROUS SCLEROSIS ASSOC, NINDS, PARKE DAVIS ID RADIAL GLIAL-CELLS; NEURONAL MIGRATION; NERVOUS-SYSTEM; FIBER SYSTEM; NEOCORTEX; CORTEX; MARKER; GOLGI; WALL; IDENTIFICATION RP CAVINESS, VS (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT VET MED & SURG,BOSTON,MA 02114, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-656-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 615 BP 187 EP 195 PG 9 WC Behavioral Sciences; Genetics & Heredity; Neurosciences; Pathology SC Behavioral Sciences; Genetics & Heredity; Neurosciences & Neurology; Pathology GA BT82C UT WOS:A1991BT82C00019 ER PT B AU SEIZINGER, BR AF SEIZINGER, BR BE JOHNSON, WG GOMEZ, MR TI TOWARD THE ISOLATION OF THE PRIMARY GENETIC-DEFECT IN VONHIPPEL-LINDAU DISEASE SO TUBEROUS SCLEROSIS AND ALLIED DISORDERS: CLINICAL, CELLULAR, AND MOLECULAR STUDIES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON TUBEROUS SCLEROSIS AND ALLIED DISORDERS CY APR 23-25, 1990 CL BETHESDA, MD SP NEW YORK ACAD SCI, NATL TUBEROUS SCLEROSIS ASSOC, NINDS, PARKE DAVIS ID RENAL-CELL CARCINOMA; SHORT ARM; CHROMOSOME-3; RETINOBLASTOMA; IDENTIFICATION; TRANSLOCATION; SEQUENCE; ALLELES; TUMORS; LOCI RP SEIZINGER, BR (reprint author), MASSACHUSETTS GEN HOSP,MOLEC NEUROONCOL LAB,BOSTON,MA 02114, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-656-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 615 BP 332 EP 337 PG 6 WC Behavioral Sciences; Genetics & Heredity; Neurosciences; Pathology SC Behavioral Sciences; Genetics & Heredity; Neurosciences & Neurology; Pathology GA BT82C UT WOS:A1991BT82C00034 ER PT B AU FONTAINE, B ROULEAU, GA SEIZINGER, BR MENON, AG JEWELL, AF MARTUZA, RL GUSELLA, JF AF FONTAINE, B ROULEAU, GA SEIZINGER, BR MENON, AG JEWELL, AF MARTUZA, RL GUSELLA, JF BE JOHNSON, WG GOMEZ, MR TI MOLECULAR-GENETICS OF NEUROFIBROMATOSIS-2 AND RELATED TUMORS (ACOUSTIC NEUROMA AND MENINGIOMA) SO TUBEROUS SCLEROSIS AND ALLIED DISORDERS: CLINICAL, CELLULAR, AND MOLECULAR STUDIES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON TUBEROUS SCLEROSIS AND ALLIED DISORDERS CY APR 23-25, 1990 CL BETHESDA, MD SP NEW YORK ACAD SCI, NATL TUBEROUS SCLEROSIS ASSOC, NINDS, PARKE DAVIS ID FAMILIAL MENINGIOMA; HUMAN CHROMOSOME-22; ANTIONCOGENES; ONCOGENES; LINKAGE RP FONTAINE, B (reprint author), MASSACHUSETTS GEN HOSP,CTR NEUROSCI,MOLEC NEUROGENET LAB,BOSTON,MA 02129, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-656-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 615 BP 338 EP 343 PG 6 WC Behavioral Sciences; Genetics & Heredity; Neurosciences; Pathology SC Behavioral Sciences; Genetics & Heredity; Neurosciences & Neurology; Pathology GA BT82C UT WOS:A1991BT82C00035 ER PT B AU SHORT, MP HAINES, J JEWELL, A BEJJANI, B YANG, CH WYANDT, H MACFARLANE, H ANDERMANN, E KWIATKOWSKI, D AMOS, J AF SHORT, MP HAINES, J JEWELL, A BEJJANI, B YANG, CH WYANDT, H MACFARLANE, H ANDERMANN, E KWIATKOWSKI, D AMOS, J BE JOHNSON, WG GOMEZ, MR TI CLINICAL FINDINGS AND LINKAGE STUDIES IN FAMILIAL TUBEROUS SCLEROSIS SO TUBEROUS SCLEROSIS AND ALLIED DISORDERS: CLINICAL, CELLULAR, AND MOLECULAR STUDIES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Note CT CONF ON TUBEROUS SCLEROSIS AND ALLIED DISORDERS CY APR 23-25, 1990 CL BETHESDA, MD SP NEW YORK ACAD SCI, NATL TUBEROUS SCLEROSIS ASSOC, NINDS, PARKE DAVIS RP SHORT, MP (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-656-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1991 VL 615 BP 380 EP 381 PG 2 WC Behavioral Sciences; Genetics & Heredity; Neurosciences; Pathology SC Behavioral Sciences; Genetics & Heredity; Neurosciences & Neurology; Pathology GA BT82C UT WOS:A1991BT82C00047 ER PT J AU ALROY, J BACHRACH, A THALHAMMER, JG PANJWANI, N RICHARD, R DEGASPERI, R WARREN, CD ALBERT, DM RAGHAVAN, SS AF ALROY, J BACHRACH, A THALHAMMER, JG PANJWANI, N RICHARD, R DEGASPERI, R WARREN, CD ALBERT, DM RAGHAVAN, SS TI CLINICAL, NEUROPHYSIOLOGICAL, BIOCHEMICAL AND MORPHOLOGICAL FEATURES OF EYES IN PERSIAN CATS WITH MANNOSIDOSIS SO VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY LA English DT Article DE CATS EYES; ALPHA-MANNOSIDOSIS ID SWAINSONINE TOXICOSIS; LIQUID-CHROMATOGRAPHY; OLIGOSACCHARIDES; SEPARATION; URINE AB The clinical, neurophysiological, morphological and biochemical manifestations of eyes from Persian kittens affected with alpha-mannosidosis were studied. Clinically the disease is characterized by progressive corneal and lenticular opacification. In addition there is asymmetry in shape and latency of signal conductions which were demonstrated by visual evoked potential studies. Morphological and histochemical studies revealed vacuolization of various ocular cell types which stained positively with Concanavalia ensiformis agglutinin (Con A) and wheat germ agglutinin (WGA). Biochemical studies illustrated low activity of acid alpha-mannosidase in cultured keratocytes and abnormal storage of partially degraded oligosaccharides in these cells, in vitreous humor and lens. This comprehensive study of ocular alpha-mannosidosis demonstrates enzyme deficiency which leads to abnormal storage of oligosaccharides in affected cells and is manifested by morphological alterations and functional impairment. C1 TUFTS UNIV,SCH VET MED,DEPT PATHOL,BOSTON,MA 02111. TUFTS UNIV,SCH VET MED,DEPT MED,BOSTON,MA 02111. TUFTS UNIV,SCH MED,DEPT OPHTHALMOL,BOSTON,MA 02111. MASSACHUSETTS GEN HOSP,CARBOHYDRATE RES LAB,BOSTON,MA 02114. MASSACHUSETTS EYE & EAR HOSP,OCULAR PATHOL LAB,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. EUNICE KENNEDY SHRIVER CTR MENTAL RETARDAT INC,DEPT BIOCHEM,WALTHAM,MA. FU NICHD NIH HHS [HD 21087]; NINDS NIH HHS [NS 21765] NR 29 TC 5 Z9 5 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-6075 J9 VIRCHOWS ARCH B JI Virchows Arch. B-Cell Molec. Pathol. PY 1991 VL 60 IS 3 BP 173 EP 180 DI 10.1007/BF02899544 PG 8 WC Pathology SC Pathology GA FK916 UT WOS:A1991FK91600005 PM 1679268 ER PT J AU PAWLYK, BS SANDBERG, MA BERSON, EL AF PAWLYK, BS SANDBERG, MA BERSON, EL TI EFFECTS OF IBMX ON THE ROD ERG OF THE ISOLATED PERFUSED CAT EYE - ANTAGONISM WITH LIGHT, CALCIUM OR L-CIS-DILTIAZEM SO VISION RESEARCH LA English DT Article DE ELECTRORETINOGRAM; RETINAL DEGENERATION; CYCLIC GMP; IBMX; CALCIUM; CATION CHANNEL BLOCKER; CGMP-PHOSPHODIESTERASE; ROD; RETINA; RETINITIS-PIGMENTOSA ID FROG PHOTORECEPTOR-MEMBRANES; CYCLIC-GMP; RETINAL DEGENERATION; CONE DYSTROPHY; PHOSPHODIESTERASE; ADAPTATION; IONS AB Full-field electroretinograms (ERGs) were recorded from isolated cat eyes perfused through the ophthalmociliary artery with the cGMP-PDE inhibitor, 3-isobutylmethylxanthine (IBMX). Under dark-adapted conditions perfusion with IBMX resulted in reduced ERG b-wave amplitudes at low stimulus luminances and supernormal b-wave amplitudes at high stimulus luminances with reduced b-wave sensitivity; b-wave implicit times were more delayed at low than at high stimulus luminances. Presentation of a steady white background or high calcium fully reversed the supernormal amplitudes and partially reversed the delayed implicit times produced by IBMX. Rod ERG b-wave sensitivity, reduced with IBMX alone, was partially reversed with calcium but further reduced with background light. Perfusion with the cation channel blocker, L-cis-diltiazem, also reversed the supernormal amplitudes produced by IBMX but had no effect on implicit times or b-wave sensitivity. Possible mechanisms of action of these antagonists and clinical implications of these findings are considered. C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,BERMAN GUND LAB STUDY RETINAL DEGENERAT,BOSTON,MA 02114. NR 20 TC 13 Z9 13 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0042-6989 J9 VISION RES JI Vision Res. PY 1991 VL 31 IS 7-8 BP 1093 EP 1097 DI 10.1016/0042-6989(91)90035-4 PG 5 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA FN144 UT WOS:A1991FN14400003 PM 1716388 ER PT J AU WEYLER, W TITLOW, CC SALACH, JI AF WEYLER, W TITLOW, CC SALACH, JI TI CATALYTICALLY ACTIVE MONOAMINE-OXIDASE TYPE-A FROM HUMAN LIVER EXPRESSED IN SACCHAROMYCES-CEREVISIAE CONTAINS COVALENT FAD SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID HUMAN-PLACENTA; BOUND FLAVIN; CDNA; FLAVOPROTEINS; SEQUENCES; BINDING; CLONING; BOVINE; SITE C1 HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114. RP WEYLER, W (reprint author), VET AFFAIRS MED CTR,4150 CLEMENT ST,SAN FRANCISCO,CA 94121, USA. NR 27 TC 50 Z9 50 U1 0 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD DEC 31 PY 1990 VL 173 IS 3 BP 1205 EP 1211 DI 10.1016/S0006-291X(05)80914-3 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EQ577 UT WOS:A1990EQ57700062 PM 2125217 ER PT J AU PERRINE, SP FALLER, DV SWERDLOW, P MILLER, BA BANK, A SYTKOWSKI, AJ RECZEK, J RUDOLPH, AM KAN, YW AF PERRINE, SP FALLER, DV SWERDLOW, P MILLER, BA BANK, A SYTKOWSKI, AJ RECZEK, J RUDOLPH, AM KAN, YW TI STOPPING THE BIOLOGIC CLOCK FOR GLOBIN GENE SWITCHING SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID SODIUM-BUTYRATE; ERYTHROID PROGENITORS; ERYTHROLEUKEMIA-CELLS; TRANSGENIC MICE; EXPRESSION; CULTURE; DELAY C1 VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, RICHMOND, VA 23298 USA. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA. UNIV CALIF SAN FRANCISCO, HOWARD HUGHES MED INST, DEPT MED, SAN FRANCISCO, CA 94143 USA. UNIV CALIF SAN FRANCISCO, HOWARD HUGHES MED INST, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USA. RP PERRINE, SP (reprint author), CHILDRENS HOSP OAKLAND RES INST, 747 52ND ST, OAKLAND, CA 94609 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD DEC 28 PY 1990 VL 612 BP 134 EP 140 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB934 UT WOS:A1990FB93400015 ER PT J AU LUSKEY, BD BING, L APPERLEY, JF ORKIN, SH WILLIAMS, DA AF LUSKEY, BD BING, L APPERLEY, JF ORKIN, SH WILLIAMS, DA TI GENE-TRANSFER INTO MURINE HEMATOPOIETIC STEM-CELLS AND BONE-MARROW STROMAL CELLS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID HUMAN ADENOSINE-DEAMINASE; BETA-GLOBIN GENE; RETROVIRAL-MEDIATED TRANSFER; LONG-TERM EXPRESSION; RECOMBINANT RETROVIRUS; TRANSPLANT RECIPIENTS; PROGENITOR CELLS; MOUSE; MICE; GENERATION C1 CHILDRENS HOSP MED CTR, BOSTON, MA 02115 USA. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA. BRIGHAM & WOMENS HOSP, DIV HEMATOL, BOSTON, MA 02115 USA. HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA. RP LUSKEY, BD (reprint author), HOWARD HUGHES MED INST, BOSTON, MA 02115 USA. NR 36 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD DEC 28 PY 1990 VL 612 BP 398 EP 406 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB934 UT WOS:A1990FB93400043 ER PT J AU JOHNSON, VA HIRSCH, MS AF JOHNSON, VA HIRSCH, MS TI NEW DEVELOPMENTS IN COMBINATION CHEMOTHERAPY OF ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS DRUGS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID HIV-1 REPLICATION INVITRO; PLACEBO-CONTROLLED TRIAL; RECOMBINANT SOLUBLE CD4; ALPHA-A-INTERFERON; SYNERGISTIC INHIBITION; SYNCYTIUM FORMATION; ZIDOVUDINE AZT; DOUBLE-BLIND; INFECTION; CASTANOSPERMINE RP JOHNSON, VA (reprint author), HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT MED, INFECT DIS UNIT, BOSTON, MA 02114 USA. NR 35 TC 0 Z9 0 U1 0 U2 1 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD DEC 26 PY 1990 VL 616 BP 318 EP 327 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FM709 UT WOS:A1990FM70900031 ER PT J AU CARPENTER, CL CANTLEY, LC AF CARPENTER, CL CANTLEY, LC TI PHOSPHOINOSITIDE KINASES SO BIOCHEMISTRY LA English DT Editorial Material ID PHOSPHATIDYLINOSITOL 4-PHOSPHATE KINASE; MIDDLE T-ANTIGEN; SACCHAROMYCES-CEREVISIAE; BOVINE BRAIN; RAT-BRAIN; PLASMA-MEMBRANE; HUMAN-PLATELETS; INOSITOL 3-PHOSPHATE; PDGF RECEPTOR; GROWTH-FACTOR C1 TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111. RP CARPENTER, CL (reprint author), MASSACHUSETTS GEN HOSP,HEMATOL ONCOL UNIT,BOSTON,MA 02114, USA. RI Cantley, Lewis/D-1800-2014 OI Cantley, Lewis/0000-0002-1298-7653 FU NIGMS NIH HHS [GM 36624, GM 41890] NR 91 TC 367 Z9 368 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD DEC 25 PY 1990 VL 29 IS 51 BP 11147 EP 11156 DI 10.1021/bi00503a001 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EP557 UT WOS:A1990EP55700001 PM 2176895 ER PT J AU MCGRANE, MM YUN, JS MOORMAN, AFM LAMERS, WH HENDRICK, GK ARAFAH, BM PARK, EA WAGNER, TE HANSON, RW AF MCGRANE, MM YUN, JS MOORMAN, AFM LAMERS, WH HENDRICK, GK ARAFAH, BM PARK, EA WAGNER, TE HANSON, RW TI METABOLIC EFFECTS OF DEVELOPMENTAL, TISSUE-SPECIFIC, AND CELL-SPECIFIC EXPRESSION OF A CHIMERIC PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) BOVINE GROWTH-HORMONE GENE IN TRANSGENIC MICE SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID PROMOTER-REGULATORY REGION; MESSENGER-RNA; RAT-LIVER; GLUTAMINE-SYNTHETASE; PYRUVATE-KINASE; ADIPOSE-CELLS; FACTOR-I; INSULIN; TRANSCRIPTION; ELEMENTS AB Transgenic mice were used to investigate sequences within the promoter of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from in rat (EC 4.1.1.32) (PEPCK) which are involved in tissue-specific and developmental regulation of gene expression. Segments of the PEPCK promoter between -2000 and -109 were linked to the structural gene for bovine growth hormone (bGH) and introduced into the germ line of mice by microinjection. Bovine growth hormone mRNA was found in tissues that express the endogenous PEPCK gene, mainly in the liver but to a lesser extent in the kidney, adipose tissue, small intestine, and mammary gland. In the liver the chimeric PEPCK/bGH(460) gene was expressed in periportal cells, which is consistent with the zonation of endogenous PEPCK. The PEPCK/bGH gene was not transcribed in the livers of fetal mice until immediately before birth; at birth the concentration of bGH mRNA increased 200-fold. Our results indicate that the region of the PEPCK promoter from -460 to +73 base pairs contains regulatory sequences required for tissue-specific and developmental regulation of PEPCK gene expression. Mice transgenic for PEPCK/bGH(460) were not hyperglycemic or hyperinsulinemic in response to elevated bGH, as were transgenic mice with the MT/bGH gene. The number of insulin receptors in skeletal muscle was no different in mice transgenic for MT/bGH when compared with mice transgenic for PEPCK/bGH(460) and control animals. However, mRNA abundance for the insulin-sensitive glucose transporter in skeletal muscle was decreased in mice transgenic for the MT/bGH gene. The differences in glucose homeostasis noted with the two types of transgenic mice may be the result of the relative site of expression, the different developmental pattern, or hormonal regulation of expression of the bGH gene. C1 CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106. CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED,CLEVELAND,OH 44106. OHIO UNIV,EDISON ANIM BIOTECHNOL CTR,ATHENS,OH 45107. UNIV AMSTERDAM,ANAT & EMBRYOL LAB,AMSTERDAM,NETHERLANDS. JOSLIN DIABET CTR,BOSTON,MA 02215. RP MCGRANE, MM (reprint author), CASE WESTERN RESERVE UNIV,SCH MED,PEW CTR MOLEC NUTR,CLEVELAND,OH 44106, USA. RI Lamers, Wouter /D-2965-2012 NR 67 TC 129 Z9 129 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD DEC 25 PY 1990 VL 265 IS 36 BP 22371 EP 22379 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EP556 UT WOS:A1990EP55600051 PM 1702419 ER PT J AU DIFIGLIA, M ROBERTS, RC BENOWITZ, LI AF DIFIGLIA, M ROBERTS, RC BENOWITZ, LI TI IMMUNOREACTIVE GAP-43 IN THE NEUROPIL OF ADULT-RAT NEOSTRIATUM - LOCALIZATION IN UNMYELINATED FIBERS, AXON TERMINALS, AND DENDRITIC SPINES SO JOURNAL OF COMPARATIVE NEUROLOGY LA English DT Article DE CAUDATE-PUTAMEN; ULTRASTRUCTURE; PLASTICITY ID GROWTH-ASSOCIATED PROTEIN; KINASE-C SUBSTRATE; BRAIN POLYPHOSPHOINOSITIDE METABOLISM; GOLDFISH OPTIC-NERVE; CAUDATE-NUCLEUS; TRANSPORTED PROTEINS; SYNAPTIC PLASTICITY; PHOSPHOPROTEIN B-50; REGENERATION; CORTEX AB GAP-43 is a neuron-specific phosphoprotein that has been implicated in neuronal development, axonal regeneration, and synaptic plasticity. Although in mammals the caudateputamen is among those brain areas that retain a high content of GAP-43 throughout life, the role of the phosphoprotein in the neostriatum is unknown. In order to understand better the possible function(s) of GAP-43 in the adult striatum, its cellular localization was examined with immunohistochemistry at the light and electron microscopic levels by using a sheep polyclonal antibody. At the light microscopic level immunoreactive GAP-43 was abundant throughout the neostriatal neuropil but was absent from neuronal somata. At the ultrastructural level, labeling was most prevalent in small unmyelinated axons (0.12-0.15-mu-m diameter). Reaction product was distributed along fibers in discrete patches about 1-mu-m apart and in preterminal sites from which vesicle-filled boutons arose. Staining was also present in small (0.35-mu-m) axon terminals that contained round vesicles and formed asymmetric synapses, mostly with thin spines. Following unilateral cortical lesions, some degenerating cortical axons in the neostriatum exhibited GAP-43 labeling. Unexpectedly, in normal striatum, GAP-43 was also occasionally found in the heads of dendritic protrusions and in thin spines that received asymmetric contacts. We speculate that in the adult neostriatum, the protein may be important in the remodeling of synapses onto medium spiny neurons that involve, in part, the corticostriatal pathway. C1 MCLEAN HOSP,BELMONT,MA 02178. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02114. RP DIFIGLIA, M (reprint author), MASSACHUSETTS GEN HOSP,CELLULAR NEUROBIOL LAB,MGH E,BLDG 149,13TH ST,BOSTON,MA 02129, USA. FU NINDS NIH HHS [NS 16367] NR 48 TC 49 Z9 49 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9967 J9 J COMP NEUROL JI J. Comp. Neurol. PD DEC 22 PY 1990 VL 302 IS 4 BP 992 EP 1001 DI 10.1002/cne.903020421 PG 10 WC Neurosciences; Zoology SC Neurosciences & Neurology; Zoology GA EP666 UT WOS:A1990EP66600020 PM 2150524 ER PT J AU NISHIMORI, T BUZZI, MG CHUDLER, EH POLETTI, CE MOSKOWITZ, MA UHL, GR AF NISHIMORI, T BUZZI, MG CHUDLER, EH POLETTI, CE MOSKOWITZ, MA UHL, GR TI PREPROENKEPHALIN UP-REGULATION IN NUCLEUS CAUDALIS - HIGH AND LOW INTENSITY AFFERENT STIMULATION DIFFERENTIALLY MODULATE EARLY AND LATE RESPONSES SO JOURNAL OF COMPARATIVE NEUROLOGY LA English DT Article DE INSITU HYBRIDIZATION; PAIN; TRIGEMINAL NERVE; GENE REGULATION ID DORSAL HORN NEURONS; PRIMARY SENSORY NEURONS; LUMBAR SPINAL-CORD; FOS-LIKE PROTEIN; TRIGEMINAL-NUCLEUS; SUBSTANTIA GELATINOSA; INSITU HYBRIDIZATION; PERIPHERAL-NERVE; MESSENGER-RNA; CYCLIC-AMP AB Nucleus caudalis expression of preproenkephalin mRNA changes following lesions depleting small-caliber primary afferent fibers and after stimulation of trigeminal afferents at different intensities. Animals treated neonatally with capsaicin display reduced preproenkephalin gene expression in nucleus caudalis neurons. Stimulation of normal animals at low intensities enhances preproenkephalin expression in a bimodal temporal pattern. High intensity stimulation is effective only at later time points in normal animals, but it causes both early and late effects on preprornkephalin expression when applied to animals neonatally lesioned with capsaicin. Transsynaptic regulation of preproenkephalin expression in pain-modulating areas of the nucleus caudalis of the trigeminal nerve thus depends on the specific type of primary afferent input. The rapid responses noted after selective large fiber stimulation appear to be suppressed by coactivation of small caliber fibers. Later responses appear less influenced by the quality of the eliciting afferent stimulus. C1 JOHNS HOPKINS UNIV, SCH MED, NIDA, ARC, MOLEC NEUROBIOL LAB, BOX 5180, BALTIMORE, MD 21224 USA. MASSACHUSETTS GEN HOSP, DEPT NEUROL, BOSTON, MA 02114 USA. MASSACHUSETTS GEN HOSP, DEPT NEUROSURG, BOSTON, MA 02114 USA. HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA. JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21224 USA. JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21224 USA. NR 56 TC 18 Z9 18 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-9967 EI 1096-9861 J9 J COMP NEUROL JI J. Comp. Neurol. PD DEC 22 PY 1990 VL 302 IS 4 BP 1002 EP 1018 DI 10.1002/cne.903020422 PG 17 WC Neurosciences; Zoology SC Neurosciences & Neurology; Zoology GA EP666 UT WOS:A1990EP66600021 PM 2081812 ER PT J AU RON, D BRASIER, AR HABENER, JF AF RON, D BRASIER, AR HABENER, JF TI TRANSCRIPTIONAL REGULATION OF HEPATIC ANGIOTENSINOGEN GENE-EXPRESSION BY THE ACUTE-PHASE RESPONSE SO MOLECULAR AND CELLULAR ENDOCRINOLOGY LA English DT Editorial Material DE ANGIOTENSINOGEN; ACUTE PHASE RESPONSE; GENE TRANSCRIPTION; INTERLEUKIN-1; NUCLEAR FACTOR-KB; GLUCOCORTICOIDS ID NF-KAPPA-B; HUMAN IMMUNODEFICIENCY VIRUS; ENHANCER-BINDING-PROTEIN; CELL-LINE; RAT; INTERLEUKIN-1; INFLAMMATION; ACTIVATION; INDUCTION; HORMONES AB The acute-phase response is a protective physiological reaction to tissue injury manifested by the immediate increase in production and secretion of liver proteins the function of which is to re-establish the homeostasis altered by injury. Such proteins include blood coagulation factors, opsonins, protease-inhibitors and angiotensinogen, a precursor of the potent vasopressor peptide angiotensin II. The angiotensinogen gene is typical of genes regulated during the acute-phase response inasmuch as the promoter regulating its transcription rate is acutely responsive to three known mediators of the acute-phase response: glucocorticoids, and the cytokines interleukin-1 and tumor necrosis factor. We present a model, based on experimental evidence, for the mechanism by which angiotensinogen gene transcription is regulated in a graded fashion by the interplay of several hormonally-inducible transcription factors that bind a hormonally-inducible enhancer unit of the angiotensinogen promoter. These factors include the glucocorticoid receptor, nuclear factor kappa B and members of the CAAT/viral enhancer (C/EBP) family of DNA-binding proteins. RP RON, D (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,HOWARD HUGHES MED INST,MOLEC ENDOCRINOL LAB,BOSTON,MA 02114, USA. NR 34 TC 34 Z9 35 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0303-7207 J9 MOL CELL ENDOCRINOL JI Mol. Cell. Endocrinol. PD DEC 21 PY 1990 VL 74 IS 3 BP C97 EP C104 DI 10.1016/0303-7207(90)90221-S PG 8 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA EP650 UT WOS:A1990EP65000002 PM 2128877 ER PT J AU LIDOV, HGW BYERS, TJ WATKINS, SC KUNKEL, LM AF LIDOV, HGW BYERS, TJ WATKINS, SC KUNKEL, LM TI LOCALIZATION OF DYSTROPHIN TO POSTSYNAPTIC REGIONS OF CENTRAL-NERVOUS-SYSTEM CORTICAL-NEURONS SO NATURE LA English DT Article C1 CHILDRENS HOSP MED CTR,DEPT NEUROL,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,DEPT NEUROL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,HOWARD HUGHES MED INST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,ELECTRON MICROSCOPY LAB,BOSTON,MA 02115. RP LIDOV, HGW (reprint author), CHILDRENS HOSP MED CTR,DEPT PATHOL,BOSTON,MA 02115, USA. NR 25 TC 335 Z9 337 U1 0 U2 1 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD DEC 20 PY 1990 VL 348 IS 6303 BP 725 EP 727 DI 10.1038/348725a0 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EP049 UT WOS:A1990EP04900057 PM 2259381 ER PT J AU SPIES, T BRESNAHAN, M BAHRAM, S ARNOLD, D BLANCK, G MELLINS, E PIOUS, D DEMARS, R AF SPIES, T BRESNAHAN, M BAHRAM, S ARNOLD, D BLANCK, G MELLINS, E PIOUS, D DEMARS, R TI A GENE IN THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II REGION CONTROLLING THE CLASS-I ANTIGEN PRESENTATION PATHWAY SO NATURE LA English DT Article C1 UNIV S FLORIDA,COLL MED,DEPT BIOCHEM & MOLEC BIOL,TAMPA,FL 33612. UNIV WASHINGTON,DEPT PEDIAT,SEATTLE,WA 98195. UNIV WISCONSIN,GENET LAB,MADISON,WI 53706. RP SPIES, T (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR VIROL,BOSTON,MA 02115, USA. RI Blanck, George/A-5365-2012 NR 29 TC 636 Z9 640 U1 0 U2 2 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD DEC 20 PY 1990 VL 348 IS 6303 BP 744 EP 747 DI 10.1038/348744a0 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EP049 UT WOS:A1990EP04900064 PM 2259384 ER PT J AU MCGANN, WJ CIRIGNANO, L ENTINE, G BIGGS, P AF MCGANN, WJ CIRIGNANO, L ENTINE, G BIGGS, P TI A NEW SOLID-STATE DETECTOR FOR RADIATION-THERAPY IMAGING SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT LA English DT Article; Proceedings Paper CT 7TH SYMP ON X-RAY AND GAMMA-RAY SOURCES AND APPLICATIONS : RADIATION MEASUREMENTS AND APPLICATIONS CY MAY 21-24, 1990 CL UNIV MICHIGAN, ANN ARBOR, MI SP US DOE, NATL INST STAND & TECHNOL, UNIV MICHIGAN, HENRY FORD HOSP, ALBION COLL, E MICHIGAN UNIV HO UNIV MICHIGAN AB A new approach to imaging the high-intensity photon flux from medical linear accelerators is described. Photovoltaic diodes made from cadmium telluride were used to generate high-contrast images in a 10 MV radiation-therapy treatment accelerator. A linear scanning array of these diodes will be capable of generating images over an area of 40 x 40 cm2 in under 5 s, a factor of 8 times faster than the current silicon-diode system. C1 MASSACHUSETTS GEN HOSP,DEPT RADIAT MED,BOSTON,MA 02114. RP MCGANN, WJ (reprint author), RADIAT MONITORING DEVICES INC,WATERTOWN,MA 02172, USA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9002 J9 NUCL INSTRUM METH A JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip. PD DEC 20 PY 1990 VL 299 IS 1-3 BP 172 EP 175 DI 10.1016/0168-9002(90)90770-7 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA EV528 UT WOS:A1990EV52800035 ER PT J AU SCHULMAN, KA KINOSIAN, B JACOBSON, TA GLICK, H WILLIAN, MK KOFFER, H EISENBERG, JM AF SCHULMAN, KA KINOSIAN, B JACOBSON, TA GLICK, H WILLIAN, MK KOFFER, H EISENBERG, JM TI REDUCING HIGH BLOOD CHOLESTEROL LEVEL WITH DRUGS - COST-EFFECTIVENESS OF PHARMACOLOGICAL MANAGEMENT SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article C1 UNIV PENN,DEPT MED,PHILADELPHIA,PA 19104. UNIV PENN,ROBERT WOOD JOHNSON FDN CLIN SCHOLARS PROGRAM,PHILADELPHIA,PA 19104. UNIV PENN,LEONARD DAVIS INST HLTH ECON,PHILADELPHIA,PA 19104. VET AFFAIRS MED CTR,PHILADELPHIA,PA. PHILADELPHIA ASSOC CLIN TRIALS,PHILADELPHIA,PA. NR 71 TC 89 Z9 89 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 19 PY 1990 VL 264 IS 23 BP 3025 EP 3033 DI 10.1001/jama.264.23.3025 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA EM763 UT WOS:A1990EM76300026 PM 2123013 ER PT J AU LOEFFLER, JS ALEXANDER, E WEN, PY SHEA, WM COLEMAN, CN KOOY, HM FINE, HA NEDZI, LA SILVER, B RIESE, NE BLACK, PM AF LOEFFLER, JS ALEXANDER, E WEN, PY SHEA, WM COLEMAN, CN KOOY, HM FINE, HA NEDZI, LA SILVER, B RIESE, NE BLACK, PM TI RESULTS OF STEREOTAXIC BRACHYTHERAPY USED IN THE INITIAL MANAGEMENT OF PATIENTS WITH GLIOBLASTOMA SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Note C1 BRIGHAM & WOMENS HOSP,NEUROSURG SERV,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,NEUROL SERV,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT RADIAT THERAPY,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT SURG,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT MED,BOSTON,MA 02115. RP LOEFFLER, JS (reprint author), BRIGHAM & WOMENS HOSP,JOINT CTR RADIAT THERAPY,50 BINNEY ST,BOSTON,MA 02115, USA. NR 22 TC 99 Z9 99 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 19 PY 1990 VL 82 IS 24 BP 1918 EP 1921 DI 10.1093/jnci/82.24.1918 PG 4 WC Oncology SC Oncology GA EN053 UT WOS:A1990EN05300015 PM 2250312 ER PT J AU BLUSZTAJN, JK GONZALEZCOVIELLA, IL LOGUE, M GROWDON, JH WURTMAN, RJ AF BLUSZTAJN, JK GONZALEZCOVIELLA, IL LOGUE, M GROWDON, JH WURTMAN, RJ TI LEVELS OF PHOSPHOLIPID CATABOLIC INTERMEDIATES, GLYCEROPHOSPHOCHOLINE AND GLYCEROPHOSPHOETHANOLAMINE, ARE ELEVATED IN BRAINS OF ALZHEIMERS-DISEASE BUT NOT OF DOWNS-SYNDROME PATIENTS SO BRAIN RESEARCH LA English DT Article DE ALZHEIMERS DISEASE; DOWNS SYNDROME; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; GLYCEROPHOSPHOCHOLINE; GLYCEROPHOSPHOETHANOLAMINE ID PLATELET MEMBRANE FLUIDITY; MAGNETIC-RESONANCE; RAT-BRAIN; DEMENTIA; CHOLINE; ACETYLCHOLINE; PROTEIN; SPECTROSCOPY; FIBROBLASTS; METABOLISM AB Concentrations of glycerophosphocholine and of glycerophosphoethanolamine, the metabolites of two major membrane phospholipid classes, phosphatidylcholine and phosphatidylethanolamine respectively, were determined post-mortem in cortical areas 20 and 40 and in cerebellum and caudate nucleus of brains obtained at autopsy from patients with Alzheimer's disease, Down's syndrome and age-matched control subjects. Glycerophosphocholine concentrations in all of the brain regions examined were higher by 67-150% in Alzheimer's disease than in control brains and 81-104% higher in Alzheimer's disease than in Down's syndrome. Glycerophosphoethanolamine concentrations were 21-52% higher in Alzheimer's disease than in controls, and 27-92% higher in Alzheimer's disease than Down's syndrome. Levels of glycerophosphocholine and of glycerophosphoethanolamine did not differ significantly between Down's syndrome and control brains. These data indicate that abnormal phospholipid metabolism in brain is characteristic of Alzheimer's disease but not Down's syndrome and suggest that this abnormality may be a central pathophysiological feature of Alzheimer's disease because levels of glycerophosphocholine and of glycerophosphoethanolamine are elevated in brain regions with and without manifestations of histopathology. C1 MIT,DEPT BRAIN & COGNIT SCI,CAMBRIDGE,MA 02139. MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114. RP BLUSZTAJN, JK (reprint author), BOSTON UNIV,SCH MED,DEPT PATHOL,ROOM M1009,85 E NEWTON ST,BOSTON,MA 02118, USA. FU NIA NIH HHS [R01AG07906, P50AG05134]; NIMH NIH HHS [MH-28783] NR 50 TC 60 Z9 60 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD DEC 17 PY 1990 VL 536 IS 1-2 BP 240 EP 244 DI 10.1016/0006-8993(90)90030-F PG 5 WC Neurosciences SC Neurosciences & Neurology GA EP510 UT WOS:A1990EP51000029 PM 2150771 ER PT J AU TAKI, J YASUDA, T TAMAKI, N FLAMM, SD HUTTER, A GOLD, HK LEINBACH, R STRAUSS, HW AF TAKI, J YASUDA, T TAMAKI, N FLAMM, SD HUTTER, A GOLD, HK LEINBACH, R STRAUSS, HW TI TEMPORAL RELATION BETWEEN LEFT-VENTRICULAR DYSFUNCTION AND CHEST PAIN IN CORONARY-ARTERY DISEASE DURING ACTIVITIES OF DAILY LIVING SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,DIV NUCL MED,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT MED,CARDIAC UNIT,BOSTON,MA 02114. RI Yasuda, Kazunori/D-4156-2012 FU NHLBI NIH HHS [HL 07416] NR 20 TC 15 Z9 15 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD DEC 15 PY 1990 VL 66 IS 20 BP 1455 EP 1458 DI 10.1016/0002-9149(90)90533-7 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EN077 UT WOS:A1990EN07700011 PM 2251991 ER PT J AU SADUN, AA LIBONDI, T AF SADUN, AA LIBONDI, T TI TRANSMISSION OF LIGHT THROUGH CATARACTS SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Letter C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,BOSTON,MA 02114. RP SADUN, AA (reprint author), UNIV SO CALIF,SCH MED,DOHENY EYE INST,DEPT OPHTHAMOL,1355 SAN PABLO ST,LOS ANGELES,CA 90033, USA. NR 5 TC 15 Z9 15 U1 0 U2 2 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD DEC 15 PY 1990 VL 110 IS 6 BP 710 EP 712 PG 3 WC Ophthalmology SC Ophthalmology GA EL935 UT WOS:A1990EL93500025 PM 2248345 ER PT J AU WARRAM, JH MARTIN, BC KROLEWSKI, AS SOELDNER, JS KAHN, CR AF WARRAM, JH MARTIN, BC KROLEWSKI, AS SOELDNER, JS KAHN, CR TI SLOW GLUCOSE REMOVAL RATE AND HYPERINSULINEMIA PRECEDE THE DEVELOPMENT OF TYPE-II DIABETES IN THE OFFSPRING OF DIABETIC PARENTS SO ANNALS OF INTERNAL MEDICINE LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP WARRAM, JH (reprint author), HARVARD UNIV,JOSLIN DIABET CTR,SCH PUBL HLTH,DIV RES,EPIDEMIOL & GENET SECT,BOSTON,MA 02215, USA. FU NIDDK NIH HHS [DK-33201, DK-36836] NR 40 TC 749 Z9 761 U1 2 U2 17 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD DEC 15 PY 1990 VL 113 IS 12 BP 909 EP 915 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA EM297 UT WOS:A1990EM29700003 PM 2240915 ER PT J AU DHAWAN, RK KHARBANDA, S NAKAMURA, M OHNO, T KUFE, D AF DHAWAN, RK KHARBANDA, S NAKAMURA, M OHNO, T KUFE, D TI EFFECTS OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ON 3'-AZIDO-3'-DEOXYTHYMIDINE UPTAKE, PHOSPHORYLATION AND NUCLEOTIDE RETENTION IN HUMAN U-937 CELLS SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; REVERSE-TRANSCRIPTASE; NUCLEOSIDE TRANSPORT; CYTOSINE-ARABINOSIDE; THYMIDINE KINASE; MAMMALIAN-CELLS; ANIMAL-CELLS; INHIBITION; 2',3'-DIDEOXYNUCLEOSIDES; 5'-TRIPHOSPHATE AB Previous studies have demonstrated that granulocyte-macrophage colony-stimulating factor (GM-CSF) both increases and decreases levels of 3-azido-3'-deoxythymidine (AZT) nucleotides in certain human myeloid cells. The present studies have examined the effects of GM-CSF on AZT metabolism in U-937 cells. The results demonstrate that GM-CSF stimulated AZT nucleotide formation in these cells. This stimulation was detectable during concurrent exposure to GM-CSF and AZT or as a result of pretreatment with GM-CSF. The GM-CSF-induced enhancement in AZT nucleotide formation was associated with a 4-fold increase in AZT uptake. The finding that uptake of AZT into U-937 cells was only partially sensitive to 6-[4-nitrobenzyl)thio]-9-beta-D-ribofuranosylpurine (NBMPR) suggested a process primarily involving nonfacilitated diffusion. The results also demonstrate that treatment of U-937 cells with GM-CSF was associated with nearly a 2-fold increase in thymidine kinase activity. Moreover, the findings indicate that retention of AZT-MP and AZP-TP was prolonged significantly (P < 0.05 and P < 0.01 respectively) in association with GM-CSF treatment. Taken together, these results suggest that GM-CSF enhances the formation of AZT nucleotides by increasing AZT uptake and phosphorylation, as well as increasing retention of phosphorylated derivatives. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,CLIN PHARMACOL LAB,BOSTON,MA 02115. NR 23 TC 17 Z9 17 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD DEC 15 PY 1990 VL 40 IS 12 BP 2695 EP 2700 DI 10.1016/0006-2952(90)90589-D PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EP086 UT WOS:A1990EP08600017 PM 2260992 ER PT J AU ROBERTSON, MJ RITZ, J AF ROBERTSON, MJ RITZ, J TI BIOLOGY AND CLINICAL RELEVANCE OF HUMAN NATURAL-KILLER-CELLS SO BLOOD LA English DT Review C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RP ROBERTSON, MJ (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,44 BINNEY ST,BOSTON,MA 02115, USA. RI Ritz, Jerome/C-7929-2009 OI Ritz, Jerome/0000-0001-5526-4669 FU NCI NIH HHS [CA-41619] NR 249 TC 784 Z9 802 U1 1 U2 9 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 15 PY 1990 VL 76 IS 12 BP 2421 EP 2438 PG 18 WC Hematology SC Hematology GA EM901 UT WOS:A1990EM90100001 PM 2265240 ER PT J AU EZEKOWITZ, RAB SIEFF, CA DINAUER, MC NATHAN, DG ORKIN, SH NEWBURGER, PE AF EZEKOWITZ, RAB SIEFF, CA DINAUER, MC NATHAN, DG ORKIN, SH NEWBURGER, PE TI RESTORATION OF PHAGOCYTE FUNCTION BY INTERFERON-GAMMA IN X-LINKED CHRONIC GRANULOMATOUS-DISEASE OCCURS AT THE LEVEL OF A PROGENITOR-CELL SO BLOOD LA English DT Note C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,HOWARD HUGHES MED INST,DEPT PEDIAT,BOSTON,MA 02115. UNIV MASSACHUSETTS,SCH MED,DEPT PEDIAT,WORCESTER,MA 01605. RP EZEKOWITZ, RAB (reprint author), HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT HEMATOL & ONCOL,DIV HEMATOL ONCOL,ENDERS 7,BOSTON,MA 02115, USA. FU NCI NIH HHS [CA38325]; NICHD NIH HHS [HD18661] NR 33 TC 32 Z9 32 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 15 PY 1990 VL 76 IS 12 BP 2443 EP 2448 PG 6 WC Hematology SC Hematology GA EM901 UT WOS:A1990EM90100003 PM 2176110 ER PT J AU CAREW, JA BROWNING, PJ LYNCH, DC AF CAREW, JA BROWNING, PJ LYNCH, DC TI SULFATION OF VONWILLEBRAND-FACTOR SO BLOOD LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. RP CAREW, JA (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,NEOPLAST DIS MECHANISMS LAB,44 BINNEY ST,BOSTON,MA 02115, USA. FU NHLBI NIH HHS [HL 31311] NR 41 TC 29 Z9 29 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 15 PY 1990 VL 76 IS 12 BP 2530 EP 2539 PG 10 WC Hematology SC Hematology GA EM901 UT WOS:A1990EM90100016 PM 2265247 ER PT J AU SONIS, AL TARBELL, N VALACHOVIC, RW GELBER, R SCHWENN, M SALLAN, S AF SONIS, AL TARBELL, N VALACHOVIC, RW GELBER, R SCHWENN, M SALLAN, S TI DENTOFACIAL DEVELOPMENT IN LONG-TERM SURVIVORS OF ACUTE LYMPHOBLASTIC-LEUKEMIA - A COMPARISON OF 3 TREATMENT MODALITIES SO CANCER LA English DT Article C1 JOINT CTR RADIAT THERAPY,BOSTON,MA. HARVARD UNIV,SCH DENT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. NEW ENGLAND MED CTR HOSP,FLOATING HOSP,BOSTON,MA 02111. RP SONIS, AL (reprint author), CHILDRENS HOSP MED CTR,300 LONGWOOD AVE,BOSTON,MA 02115, USA. NR 37 TC 78 Z9 80 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD DEC 15 PY 1990 VL 66 IS 12 BP 2645 EP 2652 DI 10.1002/1097-0142(19901215)66:12<2645::AID-CNCR2820661230>3.0.CO;2-S PG 8 WC Oncology SC Oncology GA EN145 UT WOS:A1990EN14500029 PM 2249205 ER PT J AU GARBER, JE BURKE, EM LAVALLY, BL BILLETT, AL SALLAN, SE SCOTT, RM KUPSKY, W LI, FP AF GARBER, JE BURKE, EM LAVALLY, BL BILLETT, AL SALLAN, SE SCOTT, RM KUPSKY, W LI, FP TI CHOROID-PLEXUS TUMORS IN THE BREAST-CANCER SARCOMA SYNDROME SO CANCER LA English DT Article C1 NCI,CLIN EPIDEMIOL BRANCH,CLIN STUDIES SECT,BETHESDA,MD 20892. CHILDRENS HOSP MED CTR,BOSTON,MA 02115. RP GARBER, JE (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BRAIN TUMOR WORKING GRP,44 BINNEY ST,BOSTON,MA 02115, USA. NR 18 TC 30 Z9 30 U1 1 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD DEC 15 PY 1990 VL 66 IS 12 BP 2658 EP 2660 DI 10.1002/1097-0142(19901215)66:12<2658::AID-CNCR2820661232>3.0.CO;2-C PG 3 WC Oncology SC Oncology GA EN145 UT WOS:A1990EN14500031 PM 2249207 ER PT J AU SCHULTES, NP ELLINGTON, AD CHERRY, JM SZOSTAK, JW AF SCHULTES, NP ELLINGTON, AD CHERRY, JM SZOSTAK, JW TI SACCHAROMYCES-CEREVISIAE HOMOSERINE KINASE IS HOMOLOGOUS TO PROKARYOTIC HOMOSERINE KINASES SO GENE LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,WELLMAN 9,BOSTON,MA 02114. NR 17 TC 8 Z9 9 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD DEC 15 PY 1990 VL 96 IS 2 BP 177 EP 180 DI 10.1016/0378-1119(90)90250-U PG 4 WC Genetics & Heredity SC Genetics & Heredity GA EM782 UT WOS:A1990EM78200004 PM 2176637 ER PT J AU CANTIELLO, HF PATENAUDE, CR CODINA, J BIRNBAUMER, L AUSIELLO, DA AF CANTIELLO, HF PATENAUDE, CR CODINA, J BIRNBAUMER, L AUSIELLO, DA TI G-ALPHA-I-3 REGULATES EPITHELIAL NA+ CHANNELS BY ACTIVATION OF PHOSPHOLIPASE-A2 AND LIPOXYGENASE PATHWAYS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 BAYLOR UNIV,DEPT CELL BIOL,HOUSTON,TX 77030. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RP CANTIELLO, HF (reprint author), MASSACHUSETTS GEN HOSP,RENAL UNIT,BOSTON,MA 02114, USA. FU NIDDK NIH HHS [DK-19406] NR 23 TC 105 Z9 105 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD DEC 15 PY 1990 VL 265 IS 35 BP 21624 EP 21628 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EM456 UT WOS:A1990EM45600042 PM 2174882 ER PT J AU NAKAMURA, T DATTA, R SHERMAN, ML KUFE, D AF NAKAMURA, T DATTA, R SHERMAN, ML KUFE, D TI REGULATION OF C-JUN GENE-EXPRESSION BY CAMP IN HL-60 MYELOID-LEUKEMIA CELLS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article RP NAKAMURA, T (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,CLIN PHARMACOL LAB,BOSTON,MA 02115, USA. FU NCI NIH HHS [CA01902, CA42802] NR 45 TC 42 Z9 42 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD DEC 15 PY 1990 VL 265 IS 35 BP 22011 EP 22015 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EM456 UT WOS:A1990EM45600096 PM 2174893 ER PT J AU DANG, NH TORIMOTO, Y SUGITA, K DALEY, JF SCHOW, P PRADO, C SCHLOSSMAN, SF MORIMOTO, C AF DANG, NH TORIMOTO, Y SUGITA, K DALEY, JF SCHOW, P PRADO, C SCHLOSSMAN, SF MORIMOTO, C TI CELL-SURFACE MODULATION OF CD26 BY ANTI-1F7 MONOCLONAL-ANTIBODY - ANALYSIS OF SURFACE EXPRESSION AND HUMAN T-CELL ACTIVATION SO JOURNAL OF IMMUNOLOGY LA English DT Article ID ACUTE LYMPHOBLASTIC-LEUKEMIA; T3-ANTIGEN RECEPTOR COMPLEX; DIPEPTIDYL PEPTIDASE-IV; HUMAN LYMPHOCYTES-T; ANTIGEN-RECEPTOR; NEUTRAL ENDOPEPTIDASE; T3-MOLECULAR COMPLEX; INOSITOL PHOSPHATES; RAT HEPATOCYTES; TAC ANTIGEN AB In this paper, we examined in detail the ability of anti-1 F7 to modulate 1F7 (CD26) surface expression as well as analyzed the functional relationship between the surface expression of CD3, CD2, and CD26 and human T cell activation. We showed that anti-1 F7-induced modulation is an energy-dependent process that occurs via capping and internalization of the Ag-antibody complex. Although the recovery rate for Ag reexpression of 1F7 following optimal modulation is relatively delayed, reexpression of 1F7 is greatly accelerated following phorbol ester treatment. Most importantly, we demonstrated that modulation of the CD26 Ag leads to an enhancement in the proliferative activity of modulated human T cells treated with anti-CD3 or anti-CD2, which is preceeded by an enhancement in Ca2+ mobilization. CD26 modulation also led to an increase in anti-CD3- or anti-CD2-mediated T cell clone proliferation. Finally, whereas modulation of the CD26 Ag has an effect on CD3- or CD2-induced T cell activation, modulation of the CD3/TCR complex inhibits the proliferative response of T cells incubated with anti-CD3 plus anti-1F7 or anti-CD2 plus anti-1F7. However, modulation of the CD2 structure does not affect anti-CD3-plus anti-1F7-induced human T cell activation. The above results thus provide additional evidence that the CD26 Ag plays an integral role in the regulation of human T cell activation. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,44 BINNEY ST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. FU NIAID NIH HHS [AI-12069]; NIAMS NIH HHS [AR-33713] NR 55 TC 132 Z9 132 U1 1 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 15 PY 1990 VL 145 IS 12 BP 3963 EP 3971 PG 9 WC Immunology SC Immunology GA EP041 UT WOS:A1990EP04100003 PM 1979581 ER PT J AU AMIOT, M AF AMIOT, M TI IDENTIFICATION AND ANALYSIS OF CDNA CLONES ENCODING CD53 - A PAN-LEUKOCYTE ANTIGEN RELATED TO MEMBRANE-TRANSPORT PROTEINS SO JOURNAL OF IMMUNOLOGY LA English DT Article ID MRC OX-44 ANTIGEN; MOLECULAR-CLONING; CELL; DIFFERENTIATION; SEQUENCE AB CD53 is a human cell-surface Ag expressed exclusively by nucleated cells of hemopoietic origin. In this work a cDNA clone encoding the CD53 Ag was isolated from a COS cell-expression library. The sequence of the cDNA predicts a protein of 219 residues bearing four putative membrane-spanning hydrophobic domains. Sequence analysis shows that CD53 is related to three other recently described molecules: a melanoma Ag, ME491; a B cell Ag, CD37; and the broadly distributed hemopoietic cell Ag S5.7. Comparison of NH2-terminal protein sequence of OX44 rat Ag and CD53 suggest that CD53 is the human homologue of OX44. In addition, CD53 is distantly related to Escherichia coli lac Y permease, a type III integral membrane protein that ferries lactose into the bacterial cell. CD53 transcripts increase in prevalence after mitogenic stimulation, suggesting that the protein may be involved in the transport of factors essential for cell proliferation. C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. NR 17 TC 71 Z9 72 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 15 PY 1990 VL 145 IS 12 BP 4322 EP 4325 PG 4 WC Immunology SC Immunology GA EP041 UT WOS:A1990EP04100053 PM 2258620 ER PT J AU VALGEARCHER, VE DEVILLIERS, J SINSKEY, AJ RAO, A AF VALGEARCHER, VE DEVILLIERS, J SINSKEY, AJ RAO, A TI TRANSFORMATION OF LYMPHOCYTES-T BY THE V-FOS ONCOGENE SO JOURNAL OF IMMUNOLOGY LA English DT Article ID TRANSCRIPTION FACTOR AP-1; PROTEIN-KINASE-C; GENE-EXPRESSION; AUTOCRINE STIMULATION; INDEPENDENT PATHWAYS; MURINE INTERLEUKIN-2; NUCLEOTIDE-SEQUENCE; AUTO-REGULATION; GROWTH-FACTORS; MESSENGER-RNA AB Activation of T lymphocytes through the T cell antigen receptor has been shown to stimulate a rapid and transient accumulation of c-fos mRNA and protein. Transfection of a normal murine T lymphocyte clone with the FBJ-v-fos oncogene resulted in generation of a cell line that was morphologically transformed, had lost the requirement for IL-2 for proliferation, and was tumorigenic in adult syngeneic mice; however, the transformed cells retained the ability to proliferate in response to IL-2. The transformed cells did not show constitutive expression of IL-2 or c-fos mRNA, although the promoter regions of both IL-2 and c-fos genes contain AP-1 sites that are expected to be targets for binding of Fos/Jun complexes. In contrast, the transformed T cells showed increased constitutive expression of IL-2R-alpha and c-myc mRNA; these genes may represent cellular targets for transformation by v-fos and physiologic activation by c-fos. We discuss the possibility that these transformed cells behave as cells partially activated through the TCR, and that transformation occurs through a mechanism independent of IL-2. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR VIROL,BOSTON,MA 02115. MIT,DEPT BIOL,CAMBRIDGE,MA 02139. GENET INST,CAMBRIDGE,MA 02140. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. FU NCI NIH HHS [CA42471] NR 68 TC 15 Z9 15 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 15 PY 1990 VL 145 IS 12 BP 4355 EP 4364 PG 10 WC Immunology SC Immunology GA EP041 UT WOS:A1990EP04100058 PM 2124241 ER PT J AU BOEPPLE, PA AF BOEPPLE, PA TI CASE-47-1989 - SEXUAL PRECOCITY - REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP BOEPPLE, PA (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 13 PY 1990 VL 323 IS 24 BP 1708 EP 1708 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EL856 UT WOS:A1990EL85600020 ER PT J AU JELLINEK, MS MURPHY, JM BISHOP, S POITRAST, F QUINN, D AF JELLINEK, MS MURPHY, JM BISHOP, S POITRAST, F QUINN, D TI PROTECTING SEVERELY ABUSED AND NEGLECTED CHILDREN - AN UNKEPT PROMISE SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material C1 BOSTON JUVENILE COURT,BOSTON,MA 02108. LUMEN VITAE,BOSTON,MA 02108. RP JELLINEK, MS (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. NR 9 TC 16 Z9 16 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 6 PY 1990 VL 323 IS 23 BP 1628 EP 1630 DI 10.1056/NEJM199012063232311 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA EK696 UT WOS:A1990EK69600011 PM 2233954 ER PT J AU FIORE, PM SHINGLETON, BJ AF FIORE, PM SHINGLETON, BJ TI SENILE LENS EXFOLIATION SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,BOSTON,MA 02114. RP FIORE, PM (reprint author), UNIV MED & DENT NEW JERSEY,NEWARK,NJ 07103, USA. NR 8 TC 1 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 5 PY 1990 VL 264 IS 21 BP 2755 EP 2755 DI 10.1001/jama.264.21.2755 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EK537 UT WOS:A1990EK53700029 PM 2232061 ER PT J AU ZIELSTORFF, RD JETTE, AM BARNETT, GO AF ZIELSTORFF, RD JETTE, AM BARNETT, GO TI ISSUES IN DESIGNING AN AUTOMATED RECORD SYSTEM FOR CLINICAL CARE AND RESEARCH SO ADVANCES IN NURSING SCIENCE LA English DT Article C1 NEW ENGLAND RES INST,WATERTOWN,MA. RP ZIELSTORFF, RD (reprint author), MASSACHUSETTS GEN HOSP,COMP SCI LAB,ANDOVER,MA, USA. FU AHRQ HHS [5 R18 HS05261] NR 38 TC 9 Z9 9 U1 0 U2 0 PU ASPEN PUBL INC PI FREDERICK PA 7201 MCKINNEY CIRCLE, FREDERICK, MD 21701 SN 0161-9268 J9 ADV NURS SCI JI Adv. Nurs. Sci. PD DEC PY 1990 VL 13 IS 2 BP 75 EP 88 PG 14 WC Nursing SC Nursing GA EJ778 UT WOS:A1990EJ77800009 PM 2176071 ER PT J AU HERNANDEZMUNOZ, R CABALLERIA, J BARAONA, E UPPAL, R GREENSTEIN, R LIEBER, CS AF HERNANDEZMUNOZ, R CABALLERIA, J BARAONA, E UPPAL, R GREENSTEIN, R LIEBER, CS TI HUMAN GASTRIC ALCOHOL-DEHYDROGENASE - ITS INHIBITION BY H2-RECEPTOR ANTAGONISTS, AND ITS EFFECT ON THE BIOAVAILABILITY OF ETHANOL SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article C1 BRONX VET AFFAIRS MED CTR,CTR ALCOHOL RES & TREATMENT,151G,130 W KINGSBRIDGE RD,BRONX,NY 10468. CUNY MT SINAI SCH MED,CTR ALCOHOL RES & TREATMENT,NEW YORK,NY 10029. FU NIAAA NIH HHS [AA 03508] NR 24 TC 125 Z9 125 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0145-6008 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD DEC PY 1990 VL 14 IS 6 BP 946 EP 950 DI 10.1111/j.1530-0277.1990.tb01843.x PG 5 WC Substance Abuse SC Substance Abuse GA EN628 UT WOS:A1990EN62800028 PM 1982399 ER PT J AU SCIALABBA, FA DELUCA, SA AF SCIALABBA, FA DELUCA, SA TI LYMPHOMA PRESENTING AS A PERIORBITAL TUMOR SO AMERICAN FAMILY PHYSICIAN LA English DT Article RP SCIALABBA, FA (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD DEC PY 1990 VL 42 IS 6 BP 1580 EP 1582 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EL698 UT WOS:A1990EL69800010 PM 2244549 ER PT J AU WOLFSDORF, JI PLOTKIN, RA LAFFEL, LMB CRIGLER, JF AF WOLFSDORF, JI PLOTKIN, RA LAFFEL, LMB CRIGLER, JF TI CONTINUOUS GLUCOSE FOR TREATMENT OF PATIENTS WITH TYPE-1 GLYCOGEN-STORAGE-DISEASE - COMPARISON OF THE EFFECTS OF DEXTROSE AND UNCOOKED CORNSTARCH ON BIOCHEMICAL VARIABLES SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article C1 CHILDRENS HOSP MED CTR,DEPT MED,DIV ENDOCRINOL,300 LONGWOOD AVE,BOSTON,MA 02115. JOSLIN DIABET CTR,BOSTON,MA. HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115. FU NCRR NIH HHS [RR02172] NR 37 TC 31 Z9 31 U1 1 U2 1 PU AMER SOC CLIN NUTRITION INC PI BETHESDA PA 9650 ROCKVILLE PIKE SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD DEC PY 1990 VL 52 IS 6 BP 1043 EP 1050 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EK406 UT WOS:A1990EK40600013 PM 2239779 ER PT J AU WOLFSDORF, JI RUDLIN, CR CRIGLER, JF AF WOLFSDORF, JI RUDLIN, CR CRIGLER, JF TI PHYSICAL GROWTH AND DEVELOPMENT OF CHILDREN WITH TYPE-1 GLYCOGEN-STORAGE-DISEASE - COMPARISON OF THE EFFECTS OF LONG-TERM USE OF DEXTROSE AND UNCOOKED CORNSTARCH SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article C1 CHILDRENS HOSP MED CTR,DEPT MED,DIV ENDOCRINOL,300 LONGWOOD AVE,BOSTON,MA 02115. JOSLIN DIABET CTR,BOSTON,MA. HARVARD UNIV,SCH MED,BOSTON,MA 02115. FU NCRR NIH HHS [RR02172] NR 33 TC 22 Z9 22 U1 0 U2 0 PU AMER SOC CLIN NUTRITION INC PI BETHESDA PA 9650 ROCKVILLE PIKE SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD DEC PY 1990 VL 52 IS 6 BP 1051 EP 1057 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EK406 UT WOS:A1990EK40600014 PM 2239780 ER PT J AU LOWE, DK BENFELL, K SMITH, RJ JACOBS, DO MURAWSKI, B ZIEGLER, TR WILMORE, DW AF LOWE, DK BENFELL, K SMITH, RJ JACOBS, DO MURAWSKI, B ZIEGLER, TR WILMORE, DW TI SAFETY OF GLUTAMINE-ENRICHED PARENTERAL NUTRIENT SOLUTIONS IN HUMANS SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article C1 BRIGHAM & WOMENS HOSP,75 FRANCIS ST,BOSTON,MA 02115. JOSLIN DIABET CTR,BOSTON,MA. HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. FU NIAID NIH HHS [AI 15614]; NIGMS NIH HHS [P50 GM 29327-06]; PHS HHS [29-9299] NR 28 TC 46 Z9 46 U1 0 U2 0 PU AMER SOC CLIN NUTRITION INC PI BETHESDA PA 9650 ROCKVILLE PIKE SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD DEC PY 1990 VL 52 IS 6 BP 1101 EP 1106 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EK406 UT WOS:A1990EK40600023 PM 2122714 ER PT J AU FALKSON, G CNAAN, A SIMSON, IW DAYAL, Y FALKSON, H SMITH, TJ HALLER, DG AF FALKSON, G CNAAN, A SIMSON, IW DAYAL, Y FALKSON, H SMITH, TJ HALLER, DG TI A RANDOMIZED PHASE-II STUDY OF ACIVICIN AND 4'DEOXYDOXORUBICIN IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA IN AN EASTERN COOPERATIVE ONCOLOGY GROUP-STUDY SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS LA English DT Article C1 HARVARD UNIV,SCH PUBL HLTH,DANA FARBER CANC INST,BOSTON,MA 02115. TUFTS UNIV,BOSTON,MA. HOSP UNIV PENN,PHILADELPHIA,PA 19104. RP FALKSON, G (reprint author), UNIV PRETORIA,DEPT MED ONCOL,PRIVATE BAG X169,PRETORIA 0001,SOUTH AFRICA. FU NCI NIH HHS [CA 23318, CA 21692, CA 21115] NR 12 TC 36 Z9 36 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0277-3732 J9 AM J CLIN ONCOL-CANC JI Am. J. Clin. Oncol.-Cancer Clin. Trials PD DEC PY 1990 VL 13 IS 6 BP 510 EP 515 DI 10.1097/00000421-199012000-00012 PG 6 WC Oncology SC Oncology GA EJ585 UT WOS:A1990EJ58500012 PM 2173394 ER PT J AU LAPOSATA, M TERUYA, J AF LAPOSATA, M TERUYA, J TI REAPPRAISAL OF PREOPERATIVE COAGULATION-TESTING SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Editorial Material RP LAPOSATA, M (reprint author), MASSACHUSETTS GEN HOSP,DIV LAB MED,BOSTON,MA 02114, USA. NR 3 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD DEC PY 1990 VL 94 IS 6 BP 795 EP 796 PG 2 WC Pathology SC Pathology GA EL129 UT WOS:A1990EL12900022 PM 2244599 ER PT J AU KANG, HK THOMAS, TL AF KANG, HK THOMAS, TL TI NATIONAL SOURCES OF VITAL STATUS INFORMATION - EXTENT OF COVERAGE AND POSSIBLE SELECTIVITY IN REPORTING SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Letter RP KANG, HK (reprint author), US DEPT VET AFFAIRS,OFF ENVIRONM EPIDEMIOL,WASHINGTON,DC 20006, USA. NR 7 TC 5 Z9 5 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC PY 1990 VL 132 IS 6 BP 1196 EP 1197 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EN620 UT WOS:A1990EN62000020 PM 2260551 ER PT J AU LERNMARK, A DUCAT, L EISENBARTH, G OTT, J PERMUTT, MA RUBENSTEIN, P SPIELMAN, R AF LERNMARK, A DUCAT, L EISENBARTH, G OTT, J PERMUTT, MA RUBENSTEIN, P SPIELMAN, R TI FAMILY CELL-LINES AVAILABLE FOR RESEARCH SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Letter C1 UNIV PENN,SCH MED,NATL DIABET RES INTERCHANGE,PHILADELPHIA,PA 19104. UNIV PENN,SCH MED,DEPT HUMAN GENET,PHILADELPHIA,PA 19104. JOSLIN DIABET FDN INC,BOSTON,MA 02215. COLUMBIA UNIV,NEW YORK STATE PSYCHIAT INST,DEPT GENET,NEW YORK,NY 10027. NEW YORK BLOOD CTR,NEW YORK,NY 10021. WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110. RP LERNMARK, A (reprint author), UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195, USA. NR 0 TC 58 Z9 58 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD DEC PY 1990 VL 47 IS 6 BP 1028 EP 1030 PG 3 WC Genetics & Heredity SC Genetics & Heredity GA EK400 UT WOS:A1990EK40000024 PM 2239968 ER PT J AU FINE, MJ SMITH, DN SINGER, DE AF FINE, MJ SMITH, DN SINGER, DE TI HOSPITALIZATION DECISION IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA - A PROSPECTIVE COHORT STUDY SO AMERICAN JOURNAL OF MEDICINE LA English DT Article C1 MASSACHUSETTS GEN HOSP,GEN INTERNAL MED UNIT,BOSTON,MA 02114. UNIV PITTSBURGH,DIV GEN MED,PITTSBURGH,PA 15260. FU BHP HRSA HHS [2 D28 PE51006-04] NR 27 TC 174 Z9 175 U1 0 U2 2 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD DEC PY 1990 VL 89 IS 6 BP 713 EP 721 DI 10.1016/0002-9343(90)90211-U PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA EL693 UT WOS:A1990EL69300003 PM 2252039 ER PT J AU ZHOU, WG WEI, C LEVINE, BA OLSON, MS AF ZHOU, WG WEI, C LEVINE, BA OLSON, MS TI EVIDENCE FOR PLATELET-ACTIVATING-FACTOR AS A LATE-PHASE MEDIATOR OF CHRONIC-PANCREATITIS IN THE RAT SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID GLYCERYL ETHER PHOSPHORYLCHOLINE; VASCULAR-PERMEABILITY; EXOCRINE CELLS; PAF; INFLAMMATION; NEUTROPHILS; ANTAGONIST; BN-52021; LIGATION; DAMAGE AB The role of platelet-activating factor (PAF) as a mediator of pancreatic inflammation was examined in the rat pancreatic duct ligation model of obstructive pancreatitis. Pancreatic generation of PAF, as measured by bioassay (ie, platelet[H-3]serotonin secretion), was determined at various times after induction of inflammation. Tissue levels of PAF in the normal pancreas averaged 600 +/- 49 pg/g, but PAF was not detectable during the initial 24 hours of pancreatitis, a time when the inflammatory reaction would be considered acute, that is, during the period of maximal serum amylase release and the development of interstitial edema. However a substantial increase in pancreatic PAF levels (12 times control levels) was observed 7 to 14 days after duct ligation during the late-phase response interval similar to the situation characteristic of chronic pancreatitis in which parenchymal atrophy, fibrosis, and pancreatic insufficiency evolve. One week after duct ligation when PAF levels peaked, an evaluation was made of the effects of PAF antagonists (BN52021 and WEB2170) on pancreatic lesions using Evan's blue extravasation, pancreatic myeloperoxidase (MPO) activity, and acid phosphatase activity in peritoneal lavage fluid. BN52021 or WEB2170 treatment was shown to reduce pancreatic damage and inflammation significantly. Long-term in vivo administration of exogenous PAF (20 mu-g/kg/hr for 7 days) exhibited a reduction of [H-3]thymidine uptake into and amylase release from pancreatic acini in vitro. Our observations 1) that pancreatic PAF levels increased significantly during the chronic phase of obstructive pancreatitis induced by duct ligation; 2) that inhibition of the action of PAF, through specific receptor antagonism, caused an attenuation of pancreatic lesions; and 3) that chronic administration of PAF resulted in decreased pancreatic regeneration and exocrine function are consistent with a pivotal role for PAF as a late-phase inflammatory mediator in chronic pancreatitis in rats. C1 UNIV TEXAS,HLTH SCI CTR,DEPT BIOCHEM,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT SURG,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. FU NIADDK NIH HHS [AM-19473] NR 44 TC 23 Z9 25 U1 0 U2 0 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD DEC PY 1990 VL 137 IS 6 BP 1501 EP 1508 PG 8 WC Pathology SC Pathology GA EP243 UT WOS:A1990EP24300025 PM 1701964 ER PT J AU LENCER, WI BROWN, D AUSIELLO, DA VERKMAN, AS AF LENCER, WI BROWN, D AUSIELLO, DA VERKMAN, AS TI ENDOCYTOSIS OF WATER CHANNELS IN RAT-KIDNEY - CELL SPECIFICITY AND CORRELATION WITH INVIVO ANTIDIURESIS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE WATER TRANSPORT; VASOPRESSIN; ENDOCYTOSIS; KIDNEY TUBULES; FLUORESCENCE; KINETICS; PRINCIPAL CELL; INTERCALATED CELL ID MEDULLARY COLLECTING DUCT; INTERCALATED CELLS; COATED VESICLES; URINARY-BLADDER; MEMBRANE WATER; VASOPRESSIN; PERMEABILITY; HORMONE; TUBULE; ATPASE AB Vasopressin action in the renal collecting duct is believed to be mediated by the cycling of water channels in principal and, possibly, intercalated cells. We used 6-carboxyfluorescein (6-CF) or fluorescein-labeled dextran (FITC-dextran) to determine the location and water permeability of endocytic vesicles from papilla and inner stripe of Brattleboro rats in different states of diuresis. Fifteen minutes after FITC-dextran infusion, fluorescent vesicles were concentrated at the apical pole of principal and intercalated cells. The osmotic water permeability (P(f)) of these endosomes was measured by fluorescence quenching. In papillary endosomes, P(f) was high (0.04 +/- 0.004 cm/s) when rats were in physiological states of antidiuresis or after treatment with vasopressin, 1-desamino-8-D-arginine vasopressin (DDAVP), or oxytocin; endosomes isolated from these regions of untreated animals had a low P(f). The number of papillary endosomes with high P(f) increased with increasing doses of DDAVP. Endosomes from the inner stripe also had a high P(f) only after vasopressin treatment. Confocal microscopy of sections of papilla showed that vasopressin significantly increased endocytosis in principal cells but had no effect on intercalated cells. Our data demonstrate that the bulk of fluorescently labeled vesicles from the papilla originate from the apical membrane of principal cells and contain water channels in their limiting membrane only when the rats are in physiological states of antidiuresis. In contrast, the majority of endocytosis in intercalated cells is not involved in water channel recycling. C1 MASSACHUSETTS GEN HOSP,RENAL UNIT,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,COMBINED PROGRAM PEDIAT GASTROENTEROL & NUTR,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143. FU NIDDK NIH HHS [DK-39354, DK-38452, DK-35124] NR 44 TC 29 Z9 29 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP C920 EP C932 PN 1 PG 13 WC Physiology SC Physiology GA EQ382 UT WOS:A1990EQ38200011 PM 1701969 ER PT J AU RUSSO, JJ MANULI, MA ISMAILBEIGI, F SWEADNER, KJ EDELMAN, IS AF RUSSO, JJ MANULI, MA ISMAILBEIGI, F SWEADNER, KJ EDELMAN, IS TI NA+-K+-ATPASE IN ADIPOCYTE DIFFERENTIATION IN CULTURE SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE ADIPOCYTES; 3T3-L1 CELLS; CYTODIFFERENTIATION; SODIUM-POTASSIUM-ADENOSINE-TRIPHOSPHATASE SUBUNITS, ISOFORMS, ANTIBODIES, AND K; OUABAIN; ACTIVE TRANSPORT; MESSENGER RIBONUCLEIC ACID ASSAYS; WESTERN BLOTS; NORTHERN BLOTS ID NA,K-ACTIVATED ADENOSINE-TRIPHOSPHATASE; LOW EXTERNAL K+; LIVER CELL-LINE; MESSENGER-RNAS; GLUCOSE TRANSPORTER; CATALYTIC SUBUNIT; RIBONUCLEIC-ACID; ALPHA-SUBUNIT; ION-TRANSPORT; KIDNEY-CELLS AB Differentiation of 3T3-L1 cells from a fibroblast to an adipocyte phenotype results in an approximately in an approximately 50% decline in Na+ -K+ -ATPase activity and ouabain-sensitive Rb-86 uptake. Kinetic analysis revealed a K1/2 for Na+ of approximately 14 mM, a K(m) for ATP of approximately 0.4 mM, and maximal activation by sodium dodecyl sulfate at a 0.05 (wt/wt) detergent/protein ratio in both mature fibroblasts and adipocytes. Both fibroblasts and adipocytes exhibited Na+ -K+ -ATPase activity with an inhibition constant (K(i)) for ouabain of approximately 10(-4) M. In addition, adipocytes exhibited a second component representing 30% of total activity with a K(i) of approximately 5 x 10(-7) M. The emergence of biphasic ouabain inhibition kinetics in adipocytes raised the possibility of a change in alpha-subunit isoform composition with cytodifferentiation. This inference was evaluated by isoform-specific mRNA analysis (Northern blots) and by alpha-isoform-specific immunoassays (Western blots). Northern blots revealed a modest decrease in mRNA-alpha-1, a striking increase in mRNA-alpha-2, and a significant loss of mRNA-beta content with differentiation of fibroblasts to adipocytes. By immunoassay, fibroblasts exhibited the alpha-1-isoform. Adipocytes exhibited an admixture of alpha-1- and alpha-2-isoforms, with alpha-2 being the more abundant isoform. There was no one-to-one correspondence either between the mRNA isoform and alpha-subunit abundances or between alpha-subunit abundances and enzymatic activity, suggesting that regulation occurs at multiple levels in this system. Findings indicate, however, that a shift in alpha-isoform composition accompanied by a change in ouabain inhibition kinetics occurs with cytodifferentiation. C1 COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,NEW YORK,NY 10032. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT CELLULAR & MOLEC PHYSIOL,BOSTON,MA 02115. RP RUSSO, JJ (reprint author), COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,630 W 168TH ST,NEW YORK,NY 10032, USA. FU CSP VA [CU503698]; NHLBI NIH HHS [HL-36271]; NIGMS NIH HHS [GM-36618] NR 46 TC 26 Z9 26 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP C968 EP C977 PN 1 PG 10 WC Physiology SC Physiology GA EQ382 UT WOS:A1990EQ38200016 PM 2175549 ER PT J AU THORENS, B CHENG, ZQ BROWN, D LODISH, HF AF THORENS, B CHENG, ZQ BROWN, D LODISH, HF TI LIVER GLUCOSE TRANSPORTER - A BASOLATERAL PROTEIN IN HEPATOCYTES AND INTESTINE AND KIDNEY-CELLS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE GLUCOSE TRANSPORT; POLARIZED CELLS; IMMUNOFLUORESCENCE ID PLASMA-MEMBRANE; MESSENGER-RNA; RAT; CLONING; IDENTIFICATION; LOCALIZATION; SEQUENCE; TISSUES; EXPRESSION; NA+ AB The "liver" isoform of the facilitated diffusion glucose transporter is expressed predominantly in liver, intestine, kidney, and pancreatic islet beta-cells. The apparent molecular mass of the transporter in liver, kidney, and intestine is different, as detected by Western blot analysis of membrane proteins using antipeptide antibodies. However, as assessed by Northern blot analysis and molecular cloning, the same mRNA is expressed in these tissues, indicating that there are tissue-specific posttranslational modifications of the same transporter polypeptide. As determined by immunofluorescence analysis on frozen tissue sections, the liver glucose transporter is present on the sinusoidal membrane of hepatocytes, on the basolateral membrane of fully differentiated absorptive intestine epithelial cells, and on the basolateral membrane of proximal tubule cells of the kidney nephron. This localization is consistent with the involvement of the liver glucose transporter in several key steps of glucose metabolism: glucose uptake and release by the liver and absorption or reabsorption by epithelial cells of the intestine and kidney, respectively. C1 MASSACHUSETTS GEN HOSP E,BOSTON,MA 02129. MASSACHUSETTS GEN HOSP,DEPT BIOL,BOSTON,MA 02114. RP THORENS, B (reprint author), WHITEHEAD INST BIOMED RES,9 CAMBRIDGE CTR,CAMBRIDGE,MA 02142, USA. FU NHLBI NIH HHS [HL-41484]; NIDDK NIH HHS [DK-38452]; NIGMS NIH HHS [GM-40916] NR 34 TC 149 Z9 148 U1 0 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP C279 EP C285 PN 1 PG 7 WC Physiology SC Physiology GA EQ382 UT WOS:A1990EQ38200023 PM 1701966 ER PT J AU PLOUG, T STALLKNECHT, BM PEDERSEN, O KAHN, BB OHKUWA, T VINTEN, J GALBO, H AF PLOUG, T STALLKNECHT, BM PEDERSEN, O KAHN, BB OHKUWA, T VINTEN, J GALBO, H TI EFFECT OF ENDURANCE TRAINING ON GLUCOSE-TRANSPORT CAPACITY AND GLUCOSE TRANSPORTER EXPRESSION IN RAT SKELETAL-MUSCLE SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE 3-O-METHYLGLUCOSE; GLUT-1; GLUT-4; EXERCISE; INSULIN ID INSULIN; EXERCISE; PROTEIN; GENE; STIMULATION; METABOLISM; BINDING; CELLS AB The effect of 10 wk endurance swim training on 3-O-methylglucose (3-MG) uptake (at 40mM 3-MG) in skeletal muscle was studied in the perfused rat hindquarter. Training resulted in an increase of approximately 33% for maximum insulin-stimulated 3-MG transport in fast-twitch red fibers and an increase of approximately 33% for contraction-stimulated transport in slow-twitch red fibers compared with nonexercised sedentary muscle. A fully additive effect of insulin and contractions was observed both in trained and untrained muscle. Compared with transport in control rats subjected to an almost exhaustive single exercise session the day before experiment both maximum insulin- and contraction-stimulated transport rates were increased in all muscle types in trained rats. Accordingly, the increased glucose transport capacity in trained muscle was not due to a residual effect of the last training session. Half-times for reversal of contraction-induced glucose transport were similar in trained and untrained muscles. The concentrations of mRNA for GLUT-1 (the erythrocyte-brain-Hep G2 glucose transporter) and GLUT-4 (the adipocyte-muscle glucose transporter) were increased approximately twofold by training in fast-twitch red muscle fibers. In parallel to this, Western blot demonstrated a approximately 47% increase in GLUT-1 protein and a approximately 31% increase in GLUT-4 protein. This indicates that the increases in maximum velocity for 3-MG transport in trained muscle is due to an increased number of glucose transporters. C1 UNIV COPENHAGEN,RIGSHOSP,DEPT INTERNAL MED,TTA 2001,DK-2200 COPENHAGEN,DENMARK. JOSLIN DIABET CTR,RES LAB,BOSTON,MA 02215. BETH ISRAEL HOSP,DEPT MED,DIABET UNIT,BOSTON,MA 02215. NAGOYA INST TECHNOL,NAGOYA 464,JAPAN. RP PLOUG, T (reprint author), UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL B,BLEGDAMSVEJ 3C,DK-2200 COPENHAGEN,DENMARK. NR 38 TC 155 Z9 180 U1 0 U2 8 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD DEC PY 1990 VL 259 IS 6 BP E778 EP E786 PN 1 PG 9 WC Physiology SC Physiology GA EQ382 UT WOS:A1990EQ38200027 PM 2175551 ER PT J AU WEISSLEDER, R REIMER, P LEE, AS WITTENBERG, J BRADY, TJ AF WEISSLEDER, R REIMER, P LEE, AS WITTENBERG, J BRADY, TJ TI MR RECEPTOR IMAGING - ULTRASMALL IRON-OXIDE PARTICLES TARGETED TO ASIALOGLYCOPROTEIN RECEPTORS SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP WEISSLEDER, R (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114, USA. FU NCI NIH HHS [P01-CA48729] NR 40 TC 114 Z9 119 U1 1 U2 5 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD DEC PY 1990 VL 155 IS 6 BP 1161 EP 1167 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EK408 UT WOS:A1990EK40800001 PM 2122660 ER PT J AU ZUKERBERG, LR FERRY, JA SOUTHERN, JF HARRIS, NL AF ZUKERBERG, LR FERRY, JA SOUTHERN, JF HARRIS, NL TI LYMPHOID INFILTRATES OF THE STOMACH - EVALUATION OF HISTOLOGIC CRITERIA FOR THE DIAGNOSIS OF LOW-GRADE GASTRIC LYMPHOMA ON ENDOSCOPIC BIOPSY SPECIMENS SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. RP ZUKERBERG, LR (reprint author), MASSACHUSETTS GEN HOSP,DEPT PATHOL,JAMES HOMER WRIGHT PATHOL LAB,WARREN 2,BOSTON,MA 02114, USA. NR 19 TC 92 Z9 93 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD DEC PY 1990 VL 14 IS 12 BP 1087 EP 1099 DI 10.1097/00000478-199012000-00001 PG 13 WC Pathology; Surgery SC Pathology; Surgery GA EM519 UT WOS:A1990EM51900001 PM 2133046 ER PT J AU FERRY, JA SCULLY, RE AF FERRY, JA SCULLY, RE TI MESONEPHRIC REMNANTS, HYPERPLASIA, AND NEOPLASIA IN THE UTERINE CERVIX - A STUDY OF 49 CASES SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. RP FERRY, JA (reprint author), MASSACHUSETTS GEN HOSP,DEPT PATHOL,JAMES HOMER WRIGHT LABS,BOSTON,MA 02114, USA. NR 37 TC 90 Z9 91 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD DEC PY 1990 VL 14 IS 12 BP 1100 EP 1111 DI 10.1097/00000478-199012000-00002 PG 12 WC Pathology; Surgery SC Pathology; Surgery GA EM519 UT WOS:A1990EM51900002 PM 2252101 ER PT J AU LOUIS, DN VICKERY, AL ROSAI, J AF LOUIS, DN VICKERY, AL ROSAI, J TI BRANCHIAL CLEFTLIKE CYSTS OF THE THYROID - REPLY SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Letter C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. YALE NEW HAVEN MED CTR,DEPT PATHOL,NEW HAVEN,CT 06504. YALE UNIV,SCH MED,NEW HAVEN,CT 06510. RP LOUIS, DN (reprint author), MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD DEC PY 1990 VL 14 IS 12 BP 1166 EP 1167 PG 2 WC Pathology; Surgery SC Pathology; Surgery GA EM519 UT WOS:A1990EM51900010 ER PT J AU FRIDOVICHKEIL, JL HANSEN, LJ KEYOMARSI, K PARDEE, AB AF FRIDOVICHKEIL, JL HANSEN, LJ KEYOMARSI, K PARDEE, AB TI PROGRESSION THROUGH THE CELL-CYCLE - AN OVERVIEW SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Review C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,44 BINNEY ST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. FU NCI NIH HHS [T32 CA-09361, CA-22427]; NIGMS NIH HHS [GM-24571] NR 35 TC 4 Z9 4 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD DEC PY 1990 VL 142 IS 6 SU S BP S3 EP S6 PG 4 WC Respiratory System SC Respiratory System GA EN295 UT WOS:A1990EN29500003 PM 2252273 ER PT J AU SAGER, R AF SAGER, R TI GENETIC STRATEGIES OF TUMOR SUPPRESSION SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115. RP SAGER, R (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,44 BINNEY ST,BOSTON,MA 02115, USA. FU NCI NIH HHS [CA-39814] NR 45 TC 1 Z9 1 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD DEC PY 1990 VL 142 IS 6 SU S BP S40 EP S43 PG 4 WC Respiratory System SC Respiratory System GA EN295 UT WOS:A1990EN29500011 PM 2174661 ER PT J AU CROSBY, G RUSSO, MA SZABO, MD DAVIES, KR AF CROSBY, G RUSSO, MA SZABO, MD DAVIES, KR TI SUBARACHNOID CLONIDINE REDUCES SPINAL-CORD BLOOD-FLOW AND GLUCOSE-UTILIZATION IN CONSCIOUS RATS SO ANESTHESIOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,ANAESTHESIA,BOSTON,MA 02115. UNION UNIV,ALBANY,NY 12208. RP CROSBY, G (reprint author), MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,ANESTHESIA SERV,BOSTON,MA 02114, USA. FU NIGMS NIH HHS [R01-GM 30502] NR 40 TC 34 Z9 34 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD DEC PY 1990 VL 73 IS 6 BP 1179 EP 1185 DI 10.1097/00000542-199012000-00016 PG 7 WC Anesthesiology SC Anesthesiology GA EM538 UT WOS:A1990EM53800016 PM 2248395 ER PT J AU HELFAND, M CRAPO, LM AF HELFAND, M CRAPO, LM TI SCREENING FOR THYROID-DISEASE - REPLY SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128. RP HELFAND, M (reprint author), PORTLAND VET AFFAIRS MED CTR,PORTLAND,OR 97207, USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD DEC 1 PY 1990 VL 113 IS 11 BP 897 EP 897 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EK558 UT WOS:A1990EK55800018 ER PT J AU DAGGETT, WM AF DAGGETT, WM TI POSTINFARCTION VENTRICULAR SEPTAL-DEFECT REPAIR - RETROSPECTIVE THOUGHTS AND HISTORICAL PERSPECTIVES SO ANNALS OF THORACIC SURGERY LA English DT Article RP DAGGETT, WM (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT SURG,BOSTON,MA 02114, USA. NR 27 TC 15 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD DEC PY 1990 VL 50 IS 6 BP 1006 EP 1009 PG 4 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA EL241 UT WOS:A1990EL24100036 PM 2241370 ER PT J AU JACOBY, GA BLASER, MJ SANTANAM, P HACHLER, H KAYSER, FH HARE, RS MILLER, GH AF JACOBY, GA BLASER, MJ SANTANAM, P HACHLER, H KAYSER, FH HARE, RS MILLER, GH TI APPEARANCE OF AMIKACIN AND TOBRAMYCIN RESISTANCE DUE TO 4'-AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE [ANT(4')-II] IN GRAM-NEGATIVE PATHOGENS SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article C1 VET ADM MED CTR,DENVER,CO 80220. UNIV ZURICH,CH-8006 ZURICH,SWITZERLAND. SCHERING PLOUGH CORP,BLOOMFIELD,NJ 07003. RP JACOBY, GA (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. FU NIAID NIH HHS [AI20415] NR 40 TC 34 Z9 35 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 1990 VL 34 IS 12 BP 2381 EP 2386 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA EL384 UT WOS:A1990EL38400018 PM 1965106 ER PT J AU SMITH, KL AF SMITH, KL TI APHASIA THERAPY, 2ND EDITION - CODE,C, MULLER,D SO APPLIED PSYCHOLINGUISTICS LA English DT Book Review RP SMITH, KL (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0142-7164 J9 APPL PSYCHOLINGUIST JI Appl. Psycholinguist. PD DEC PY 1990 VL 11 IS 4 BP 459 EP 461 PG 3 WC Linguistics; Psychology, Experimental SC Linguistics; Psychology GA ET476 UT WOS:A1990ET47600010 ER PT J AU SHARPE, RJ SALASCHE, SJ BARNHILL, RL SOBER, AJ AF SHARPE, RJ SALASCHE, SJ BARNHILL, RL SOBER, AJ TI NONEPIDERMAL ORIGIN OF CUTANEOUS MELANOMA IN A SMALL CONGENITAL NEVUS SO ARCHIVES OF DERMATOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP SHARPE, RJ (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD DEC PY 1990 VL 126 IS 12 BP 1559 EP 1561 DI 10.1001/archderm.126.12.1559 PG 3 WC Dermatology SC Dermatology GA EN404 UT WOS:A1990EN40400002 PM 2256683 ER PT J AU LATINA, MA DOBROGOWSKI, M MARCH, WF BIRNGRUBER, R AF LATINA, MA DOBROGOWSKI, M MARCH, WF BIRNGRUBER, R TI LASER SCLEROSTOMY BY PULSED-DYE LASER AND GONIOLENS SO ARCHIVES OF OPHTHALMOLOGY LA English DT Article C1 EYE RES INST,BOSTON,MA. UNIV OKLAHOMA,HLTH SCI CTR,MCGEE EYE INST,GLAUCOMA SERV,OKLAHOMA CITY,OK 73190. MASSACHUSETTS EYE & EAR HOSP,GLAUCOMA CONSULTAT SERV,BOSTON,MA 02114. RP LATINA, MA (reprint author), MASSACHUSETTS GEN HOSP,WELLMAN LABS PHOTOMED,BOSTON,MA 02114, USA. RI Birngruber, Reginald/Q-2342-2016 FU NEI NIH HHS [R43-EY08019] NR 29 TC 35 Z9 35 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD DEC PY 1990 VL 108 IS 12 BP 1745 EP 1750 PG 6 WC Ophthalmology SC Ophthalmology GA EN061 UT WOS:A1990EN06100032 PM 2256848 ER PT J AU SAWICKI, MP HOWARD, TJ DALTON, M STABILE, BE PASSARO, E AF SAWICKI, MP HOWARD, TJ DALTON, M STABILE, BE PASSARO, E TI THE DICHOTOMOUS DISTRIBUTION OF GASTRINOMAS SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 14TH ANNUAL SURGICAL SYMP OF THE ASSOC OF VETERANS AFFAIR SURGEONS CY MAY 07, 1990 CL CHARLESTON, SC SP ASSOC VETERANS AFFAIR SURGEONS C1 W LOS ANGELES VET AFFAIRS MED CTR,SURG SERV,LOS ANGELES,CA. VET ADM MED CTR,SURG SERV,SAN DIEGO,CA 92161. RP SAWICKI, MP (reprint author), UNIV CALIF LOS ANGELES,SCH MED,DEPT SURG,LOS ANGELES,CA 90024, USA. NR 21 TC 9 Z9 9 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD DEC PY 1990 VL 125 IS 12 BP 1584 EP 1587 PG 4 WC Surgery SC Surgery GA EL385 UT WOS:A1990EL38500014 PM 1978773 ER PT J AU BITTMAN, EL WEAVER, DR AF BITTMAN, EL WEAVER, DR TI THE DISTRIBUTION OF MELATONIN BINDING-SITES IN NEUROENDOCRINE TISSUES OF THE EWE SO BIOLOGY OF REPRODUCTION LA English DT Article C1 UNIV MASSACHUSETTS,PROGRAM NEUROSCI & BEHAV,AMHERST,MA 01003. MASSACHUSETTS GEN HOSP,CHILDRENS SERV,DEV CHRONOBIOL LAB,BOSTON,MA 02114. RP BITTMAN, EL (reprint author), UNIV MASSACHUSETTS,DEPT ZOOL,AMHERST,MA 01003, USA. FU NICHD NIH HHS [HD-06976]; NIMH NIH HHS [MH R01-44132] NR 58 TC 100 Z9 100 U1 0 U2 0 PU SOC STUDY REPRODUCTION PI MADISON PA 1603 MONROE ST, MADISON, WI 53711-2021 SN 0006-3363 J9 BIOL REPROD JI Biol. Reprod. PD DEC PY 1990 VL 43 IS 6 BP 986 EP 993 DI 10.1095/biolreprod43.6.986 PG 8 WC Reproductive Biology SC Reproductive Biology GA EJ831 UT WOS:A1990EJ83100010 PM 2291931 ER PT J AU SLUSS, PM EWING, JF SCHNEYER, AL AF SLUSS, PM EWING, JF SCHNEYER, AL TI PHOSPHOLIPASE-C-MEDIATED RELEASE OF LOW-MOLECULAR-WEIGHT FOLLICLE-STIMULATING-HORMONE RECEPTOR-BINDING INHIBITOR FROM TESTIS MEMBRANES SO BIOLOGY OF REPRODUCTION LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT MED,REPROD ENDOCRINE UNIT,BOSTON,MA 02114. RP SLUSS, PM (reprint author), UNIV ROCHESTER,SCH MED,UROL RES LABS,BOX 656,601 ELMWOOD AVE,ROCHESTER,NY 14642, USA. FU NCRR NIH HHS [S7RR05403-28]; NICHD NIH HHS [HD19302] NR 13 TC 6 Z9 6 U1 0 U2 0 PU SOC STUDY REPRODUCTION PI MADISON PA 1603 MONROE ST, MADISON, WI 53711-2021 SN 0006-3363 J9 BIOL REPROD JI Biol. Reprod. PD DEC PY 1990 VL 43 IS 6 BP 1026 EP 1031 DI 10.1095/biolreprod43.6.1026 PG 6 WC Reproductive Biology SC Reproductive Biology GA EJ831 UT WOS:A1990EJ83100016 PM 2127230 ER PT J AU FALCONE, A DARNOWSKI, JW RUPRECHT, RM CHU, SH BRUNETTI, I CALABRESI, P AF FALCONE, A DARNOWSKI, JW RUPRECHT, RM CHU, SH BRUNETTI, I CALABRESI, P TI DIFFERENTIAL EFFECT OF BENZYLACYCLOURIDINE ON THE TOXIC AND THERAPEUTIC EFFECTS OF AZIDOTHYMIDINE IN MICE SO BLOOD LA English DT Article C1 ROGER WILLIAMS GEN HOSP,DEPT MED,825 CHALKSTONE AVE,PROVIDENCE,RI 02908. BROWN UNIV,PROVIDENCE,RI 02912. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. FU NCI NIH HHS [CA 13943]; NIAID NIH HHS [AI 24845] NR 23 TC 26 Z9 28 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 1 PY 1990 VL 76 IS 11 BP 2216 EP 2221 PG 6 WC Hematology SC Hematology GA EK727 UT WOS:A1990EK72700008 PM 2257295 ER PT J AU VANHINSBERGH, VWM BAUER, KA KOOISTRA, T KLUFT, C DOOIJEWAARD, G SHERMAN, ML NIEUWENHUIZEN, W AF VANHINSBERGH, VWM BAUER, KA KOOISTRA, T KLUFT, C DOOIJEWAARD, G SHERMAN, ML NIEUWENHUIZEN, W TI PROGRESS OF FIBRINOLYSIS DURING TUMOR-NECROSIS-FACTOR INFUSIONS IN HUMANS - CONCOMITANT INCREASE IN TISSUE-TYPE PLASMINOGEN-ACTIVATOR, PLASMINOGEN-ACTIVATOR INHIBITOR TYPE-1, AND FIBRIN(OGEN) DEGRADATION PRODUCTS SO BLOOD LA English DT Article C1 BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215. HARVARD UNIV,SCH MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,CLIN PHARMACOL LAB,BOSTON,MA 02115. RP VANHINSBERGH, VWM (reprint author), TNO,GAUBIUS INST,POB 612,2300 AP LEIDEN,NETHERLANDS. FU NHLBI NIH HHS [P01 HL33014] NR 30 TC 100 Z9 102 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 1 PY 1990 VL 76 IS 11 BP 2284 EP 2289 PG 6 WC Hematology SC Hematology GA EK727 UT WOS:A1990EK72700018 PM 1701665 ER PT J AU SCHAPIRA, L ANTIN, JH RANSIL, BJ ANTMAN, KH EDER, JP MCGARIGLE, CJ GOLDBERG, MA AF SCHAPIRA, L ANTIN, JH RANSIL, BJ ANTMAN, KH EDER, JP MCGARIGLE, CJ GOLDBERG, MA TI SERUM ERYTHROPOIETIN LEVELS IN PATIENTS RECEIVING INTENSIVE CHEMOTHERAPY AND RADIOTHERAPY SO BLOOD LA English DT Article C1 BRIGHAM & WOMENS HOSP,DEPT MED,DIV HEMATOL,75 FRANCIS ST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,BETH ISRAEL HOSP,CHARLES A DANA RES INST,DEPT MED,DIV MED ONCOL,THORNDIKE LAB,BOSTON,MA 02215. HARVARD UNIV,SCH MED,BOSTON,MA 02115. FU NCI NIH HHS [P01CA38493, CA39542]; NIDDK NIH HHS [DK01401] NR 28 TC 85 Z9 85 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 1 PY 1990 VL 76 IS 11 BP 2354 EP 2359 PG 6 WC Hematology SC Hematology GA EK727 UT WOS:A1990EK72700028 PM 2257306 ER PT J AU KLUMPP, TR CALIGURI, MA RABINOWE, SN SOIFFER, RJ MURRAY, C RITZ, J AF KLUMPP, TR CALIGURI, MA RABINOWE, SN SOIFFER, RJ MURRAY, C RITZ, J TI AUTOIMMUNE PANCYTOPENIA FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION SO BONE MARROW TRANSPLANTATION LA English DT Article ID IMMUNE HEMOLYSIS; THROMBOCYTOPENIA; ANTIBODIES; NEUTROPENIA AB A 47-year-old female developed autoimmune hemolytic anemia, autoimmune neutropenia, and autoimmune thrombocytopenia 19 months following allogeneic bone marrow transplantation for chronic myelogenous leukemia. Treatment with high-dose corticosteroids resulted in marked improvement in all three cell lines. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RI Ritz, Jerome/C-7929-2009 OI Ritz, Jerome/0000-0001-5526-4669 FU NIAID NIH HHS [N01-AI62531] NR 18 TC 38 Z9 38 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0268-3369 J9 BONE MARROW TRANSPL JI Bone Marrow Transplant. PD DEC PY 1990 VL 6 IS 6 BP 445 EP 447 PG 3 WC Biophysics; Oncology; Hematology; Immunology; Transplantation SC Biophysics; Oncology; Hematology; Immunology; Transplantation GA ER425 UT WOS:A1990ER42500016 PM 1965793 ER PT J AU AOBA, T MORENO, EC AF AOBA, T MORENO, EC TI CHANGES IN THE NATURE AND COMPOSITION OF ENAMEL MINERAL DURING PORCINE AMELOGENESIS SO CALCIFIED TISSUE INTERNATIONAL LA English DT Article RP FORSYTH DENT CTR, DEPT PHYS CHEM, 140 FENWAY, BOSTON, MA 02115 USA. FU NCRR NIH HHS [S10-RR-03833]; NIDCR NIH HHS [DE03187, DE08670] NR 36 TC 36 Z9 37 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0171-967X EI 1432-0827 J9 CALCIFIED TISSUE INT JI Calcif. Tissue Int. PD DEC PY 1990 VL 47 IS 6 BP 356 EP 364 DI 10.1007/BF02555887 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EK494 UT WOS:A1990EK49400006 PM 1963381 ER PT J AU GRAEMECOOK, F BELL, DA FLOTTE, TJ PREFFER, F PASTELLEVY, C NARDI, G COMPTON, C AF GRAEMECOOK, F BELL, DA FLOTTE, TJ PREFFER, F PASTELLEVY, C NARDI, G COMPTON, C TI ANEUPLOIDY IN PANCREATIC INSULINOMAS DOES NOT PREDICT MALIGNANCY SO CANCER LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT PATHOL,WARREN 2,15 FRUIT ST,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT SURG,BOSTON,MA 02114. NR 20 TC 27 Z9 28 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD DEC 1 PY 1990 VL 66 IS 11 BP 2365 EP 2368 DI 10.1002/1097-0142(19901201)66:11<2365::AID-CNCR2820661119>3.0.CO;2-L PG 4 WC Oncology SC Oncology GA EL262 UT WOS:A1990EL26200018 PM 2245392 ER PT J AU WOO, SB SONIS, ST SONIS, AL AF WOO, SB SONIS, ST SONIS, AL TI THE ROLE OF HERPES-SIMPLEX VIRUS IN THE DEVELOPMENT OF ORAL MUCOSITIS IN BONE-MARROW TRANSPLANT RECIPIENTS SO CANCER LA English DT Article C1 HARVARD UNIV,SCH DENT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,BOSTON,MA 02115. RP WOO, SB (reprint author), BRIGHAM & WOMENS HOSP,BRIGHAM DENT GRP,75 FRANCIS ST,BOSTON,MA 02115, USA. FU PHS HHS [35-043-8519-Z-30] NR 19 TC 33 Z9 33 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD DEC 1 PY 1990 VL 66 IS 11 BP 2375 EP 2379 DI 10.1002/1097-0142(19901201)66:11<2375::AID-CNCR2820661121>3.0.CO;2-6 PG 5 WC Oncology SC Oncology GA EL262 UT WOS:A1990EL26200020 PM 2173971 ER PT J AU GARBER, JE LIEPMAN, MK GELLES, EJ CORSON, JM ANTMAN, KH AF GARBER, JE LIEPMAN, MK GELLES, EJ CORSON, JM ANTMAN, KH TI MELANOMA AND SOFT-TISSUE SARCOMA IN 7 PATIENTS SO CANCER LA English DT Article C1 NCI,CLIN EPIDEMIOL BRANCH,CLIN STUDIES SECT,BETHESDA,MD 20892. CENT MASSACHUSETTS MEM HOSP,MED CTR,DIV HEMATOL ONCOL,WORCESTER,MA. BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115. RP GARBER, JE (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV MED ONCOL,44 BINNEY ST,BOSTON,MA 02115, USA. NR 21 TC 14 Z9 14 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD DEC 1 PY 1990 VL 66 IS 11 BP 2432 EP 2434 DI 10.1002/1097-0142(19901201)66:11<2432::AID-CNCR2820661132>3.0.CO;2-C PG 3 WC Oncology SC Oncology GA EL262 UT WOS:A1990EL26200031 PM 2245401 ER PT J AU CAPILOUTO, ML DEPAOLA, PF GRON, P AF CAPILOUTO, ML DEPAOLA, PF GRON, P TI INVIVO STUDY OF SLOW-RELEASE FLUORIDE RESIN AND ENAMEL UPTAKE SO CARIES RESEARCH LA English DT Article DE ENAMEL FLUORIDE; FLUORIDE UPTAKE; SLOW-RELEASE FLUORIDE RESIN ID CARIES; PREVENTION; SEALANT AB The purpose of this study was to investigate in vivo enamel fluoride uptake of a slow-release boron trifluoride BIS-GMA resin material. Study subjects were orthodontic patients with at least one pair of permanent bicuspid teeth indicated for extraction. The material was applied to the buccal surface of the test tooth 1 month prior to extraction; the contralateral tooth served as the control tooth. Following extraction, the resin was removed by soaking in acetone for 36 h and polishing with a sodium bicarbonate slurry. Prior scanning electron microscopic studies have shown that this cleaning procedure effectively removes all residual resin. Enamel fluoride analyses were completed for 12 pairs of teeth from 9 subjects. The mean differences in enamel fluoride concentrations between the treated and control teeth were significantly different from zero at the 0.01 level. At each successive depth, the absolute mean amount of fluoride uptake by the test teeth was fairly constant; however, the proportional mean amount or percent increase in fluoride concentration resulting from treatment became greater in the deeper enamel layers. The data suggest that this material has the potential to provide an effective means of introducing substantial amounts of permanently bound fluoride into surface enamel, even into the deeper layers. C1 FORSYTH DENT CTR,DEPT CLIN TRIALS & EXPERIMENTAT,BOSTON,MA 02115. FU NIDCR NIH HHS [5 T32 DE07151, DE-5067] NR 24 TC 8 Z9 8 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0008-6568 J9 CARIES RES JI Caries Res. PD DEC PY 1990 VL 24 IS 6 BP 441 EP 445 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA ER665 UT WOS:A1990ER66500004 PM 2149675 ER PT J AU HEMLER, ME ELICES, MJ CHAN, BMC ZETTER, B MATSUURA, N TAKADA, Y AF HEMLER, ME ELICES, MJ CHAN, BMC ZETTER, B MATSUURA, N TAKADA, Y TI MULTIPLE LIGAND-BINDING FUNCTIONS FOR VLA-2 (ALPHA-2-BETA-1) AND VLA-3 (ALPHA-3-BETA-1) IN THE INTEGRIN FAMILY SO CELL DIFFERENTIATION AND DEVELOPMENT LA English DT Article; Proceedings Paper CT 13TH SIGRID JUSELIUS SYMP : CELL-MATRIX CONTACTS AND PERICELLULAR PROTEOLYSIS CY AUG 12-15, 1990 CL HELSINKI, FINLAND ID ADHESION RECEPTORS; LAMININ RECEPTOR; CELLS; COLLAGEN; ATTACHMENT; SUBUNIT C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. HARVARD UNIV,CHILDRENS HOSP,SCH MED,BOSTON,MA 02115. OI takada, yoshikazu/0000-0001-5481-9589 FU NIGMS NIH HHS [GM38903] NR 32 TC 54 Z9 54 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0922-3371 J9 CELL DIFFER DEV PD DEC PY 1990 VL 32 IS 3 BP 229 EP 238 DI 10.1016/0922-3371(90)90035-U PG 10 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA FE611 UT WOS:A1990FE61100006 PM 1965952 ER PT J AU BAUME, DM CALIGIURI, MA MANLEY, TJ DALEY, JF RITZ, J AF BAUME, DM CALIGIURI, MA MANLEY, TJ DALEY, JF RITZ, J TI DIFFERENTIAL EXPRESSION OF CD8-ALPHA AND CD8-BETA ASSOCIATED WITH MHC-RESTRICTED AND NON-MHC-RESTRICTED CYTOLYTIC EFFECTOR-CELLS SO CELLULAR IMMUNOLOGY LA English DT Article RP BAUME, DM (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT MED,DIV TUMOR IMMUNOL,BOSTON,MA 02115, USA. RI Ritz, Jerome/C-7929-2009 OI Ritz, Jerome/0000-0001-5526-4669 FU NCI NIH HHS [CA41619] NR 40 TC 62 Z9 62 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0008-8749 J9 CELL IMMUNOL JI Cell. Immunol. PD DEC PY 1990 VL 131 IS 2 BP 352 EP 365 DI 10.1016/0008-8749(90)90260-X PG 14 WC Cell Biology; Immunology SC Cell Biology; Immunology GA EL718 UT WOS:A1990EL71800008 PM 2122925 ER PT J AU THOMAS, JD AF THOMAS, JD TI FLOW IN THE DESCENDING AORTA - A TURN OF THE SCREW OR A SIDEWAYS GLANCE SO CIRCULATION LA English DT Editorial Material C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,NONINVAS CARDIAC LAB,BOSTON,MA 02114. NR 25 TC 19 Z9 19 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD DEC PY 1990 VL 82 IS 6 BP 2263 EP 2265 PG 3 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EL841 UT WOS:A1990EL84100047 PM 2242551 ER PT J AU FREEMAN, GL COLSTON, JT AF FREEMAN, GL COLSTON, JT TI EVALUATION OF LEFT-VENTRICULAR MECHANICAL RESTITUTION IN CLOSED-CHEST DOGS BASED ON SINGLE-BEAT ELASTANCE SO CIRCULATION RESEARCH LA English DT Article C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 25 TC 28 Z9 28 U1 1 U2 1 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7330 J9 CIRC RES JI Circ.Res. PD DEC PY 1990 VL 67 IS 6 BP 1437 EP 1445 PG 9 WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Hematology GA EM020 UT WOS:A1990EM02000014 PM 1700935 ER PT J AU JANG, IK GOLD, HK LEINBACH, RC FALLON, JT COLLEN, D AF JANG, IK GOLD, HK LEINBACH, RC FALLON, JT COLLEN, D TI INVIVO THROMBIN INHIBITION ENHANCES AND SUSTAINS ARTERIAL RECANALIZATION WITH RECOMBINANT TISSUE-TYPE PLASMINOGEN-ACTIVATOR SO CIRCULATION RESEARCH LA English DT Article C1 MASSACHUSETTS GEN HOSP,CARDIAC UNIT,ACC 4,ROOM 480,15 PARKMAN ST,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. UNIV VERMONT,COLL MED,DEPT BIOCHEM,BURLINGTON,VT 05405. UNIV VERMONT,COLL MED,DEPT MED,BURLINGTON,VT 05405. FU NHLBI NIH HHS [HL-26215, HL-35058] NR 41 TC 76 Z9 77 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7330 J9 CIRC RES JI Circ.Res. PD DEC PY 1990 VL 67 IS 6 BP 1552 EP 1561 PG 10 WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Hematology GA EM020 UT WOS:A1990EM02000025 PM 2123135 ER PT J AU TOMERA, JF MARTYN, J AF TOMERA, JF MARTYN, J TI EFFECTS OF ENDOTOXIN INFECTION ON CYCLIC-NUCLEOTIDES IN VENTRICULAR AND GASTROCNEMIUS-MUSCLE SO CIRCULATORY SHOCK LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT ANESTHESIOL,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,ANESTHESIA SERV,BOSTON,MA 02114. RP TOMERA, JF (reprint author), SHRINERS BURN INST,ANESTHESIA SERV,51 BLOSSOM ST,BOSTON,MA 02114, USA. FU NIGMS NIH HHS [GM 31569] NR 32 TC 9 Z9 9 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0092-6213 J9 CIRC SHOCK JI Circ. Shock PD DEC PY 1990 VL 32 IS 4 BP 281 EP 292 PG 12 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EM548 UT WOS:A1990EM54800003 PM 1963121 ER PT J AU FLOOD, J LIEDTKE, R MATTENHEIMER, H ROTHOUSE, L TRUNDLE, D VROON, D WHISLER, K COLLINSWORTH, W AF FLOOD, J LIEDTKE, R MATTENHEIMER, H ROTHOUSE, L TRUNDLE, D VROON, D WHISLER, K COLLINSWORTH, W TI A MULTICENTER EVALUATION OF THE BOEHRINGER MANNHEIM HITACHI-717 SYSTEM SO CLINICAL BIOCHEMISTRY LA English DT Article C1 LAB PATHOL,SEATTLE,WA 98104. COMMUNITY HOSP,DEPT PATHOL INC,INDIANAPOLIS,IN 46219. MORTON PLANT HOSP,ADLER INST LAB MED,CLEARWATER,FL 34617. BOEHRINGER MANNHEIM DIAGNOST,INDIANAPOLIS,IN 46250. RUSH PRESBYTERIAN ST LUKES MED CTR,OFF CONSOLIDATED LAB SERV,CLIN CHEM LAB,CHICAGO,IL 60612. RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT BIOCHEM,CHICAGO,IL 60612. GRADY MEM HOSP,DEPT PATHOL & LAB MED,ATLANTA,GA 30303. RP FLOOD, J (reprint author), MASSACHUSETTS GEN HOSP,DEPT CHEM,BOSTON,MA 02114, USA. NR 7 TC 9 Z9 9 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0009-9120 J9 CLIN BIOCHEM JI Clin. Biochem. PD DEC PY 1990 VL 23 IS 6 BP 477 EP 488 DI 10.1016/0009-9120(90)80036-I PG 12 WC Medical Laboratory Technology SC Medical Laboratory Technology GA EM829 UT WOS:A1990EM82900002 PM 2289305 ER PT J AU BLAND, EF AF BLAND, EF TI SPRAGUE,HOWARD,B. (1895-1970) SO CLINICAL CARDIOLOGY LA English DT Item About an Individual C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,BOSTON,MA 02114. NR 7 TC 0 Z9 0 U1 0 U2 0 PU CLINICAL CARDIOLOGY PUBL CO PI MAHWAH PA PO BOX 832, MAHWAH, NJ 07430-0832 SN 0160-9289 J9 CLIN CARDIOL JI Clin. Cardiol. PD DEC PY 1990 VL 13 IS 12 BP 888 EP 889 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EK867 UT WOS:A1990EK86700015 PM 2282735 ER PT J AU MURPHY, SB KIJEWSKI, PK MILLIS, MB HARLESS, A AF MURPHY, SB KIJEWSKI, PK MILLIS, MB HARLESS, A TI ACETABULAR DYSPLASIA IN THE ADOLESCENT AND YOUNG-ADULT SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article; Proceedings Paper CT 18TH OPEN SCIENTIFIC MEETING OF THE HIP SOC CY FEB 11, 1990 CL NEW ORLEANS, LA SP HIP SOC C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT RADIAT THERAPY,BOSTON,MA 02115. HARVARD UNIV,SCH MED,JOINT CTR RADIAT THERAPY,BOSTON,MA 02115. RP MURPHY, SB (reprint author), CHILDRENS HOSP MED CTR,DEPT ORTHOPAED SURG,BOSTON,MA 02115, USA. NR 22 TC 121 Z9 124 U1 0 U2 3 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD DEC PY 1990 IS 261 BP 214 EP 223 PG 10 WC Orthopedics; Surgery SC Orthopedics; Surgery GA EL720 UT WOS:A1990EL72000023 ER PT J AU GOLDMAN, L COOK, EF ORAV, J EPSTEIN, AM KOMAROFF, AL DELBANCO, TL MULLEY, AG HIATT, HH AF GOLDMAN, L COOK, EF ORAV, J EPSTEIN, AM KOMAROFF, AL DELBANCO, TL MULLEY, AG HIATT, HH TI RESEARCH TRAINING IN CLINICAL EFFECTIVENESS - REPLACING IN MY EXPERIENCE - WITH RIGOROUS CLINICAL INVESTIGATION SO CLINICAL RESEARCH LA English DT Article C1 BRIGHAM & WOMENS HOSP,DEPT MED,DIV GEN MED,BOSTON,MA 02115. BETH ISRAEL HOSP,DIV GEN MED,BOSTON,MA 02215. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,GEN INTERNAL MED UNIT,BOSTON,MA 02114. HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL,BOSTON,MA 02115. HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT,BOSTON,MA 02115. HARVARD UNIV,SCH PUBL HLTH,DEPT HLTH POLICY & MANAGEMENT,BOSTON,MA 02115. RP GOLDMAN, L (reprint author), BRIGHAM & WOMENS HOSP,DEPT MED,DIV CLIN EPIDEMIOL,75 FRANCIS ST,BOSTON,MA 02115, USA. NR 18 TC 15 Z9 15 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP 686 EP 693 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900002 PM 2276256 ER PT J AU BAUER, RL AF BAUER, RL TI ARE FALLERS FRAIL - AN ANALYSIS OF BONE-DENSITY IN FALLERS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A1001 EP A1001 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900447 ER PT J AU BEER, WH HUDSON, J GUENTZEL, N JOHNSON, RF SCHENKER, S AF BEER, WH HUDSON, J GUENTZEL, N JOHNSON, RF SCHENKER, S TI ZINC TRANSPORT BY THE HUMAN PLACENTA, EFFECT OF ALCOHOL AND LIGAND SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. UNIV TEXAS,DEPT LIFE SCI,SAN ANTONIO,TX 78285. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A939 EP A939 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900127 ER PT J AU FREYALDENHOVEN, AM KATZ, MS AF FREYALDENHOVEN, AM KATZ, MS TI EFFECTS OF PROTEIN-KINASE-C ACTIVATION ON HORMONE-SENSITIVE ADENYLATE-CYCLASE AND PROTEIN-PHOSPHORYLATION IN CLONAL OSTEOBLAST-LIKE CELLS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A953 EP A953 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900206 ER PT J AU HARFORD, PH DENEKE, SM JENKINSON, SG AF HARFORD, PH DENEKE, SM JENKINSON, SG TI INCREASED CYSTINE UPTAKE AND GLUTATHIONE LEVELS IN CHINESE-HAMSTER OVARY CELLS EXPOSED TO DISULFIRAM SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 AUDIE L MURPHY MEM VET ADM MED CTR,DEPT MED,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A957 EP A957 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900228 ER PT J AU HENDERSON, GI ANTONY, A PEREZ, A JOHNSON, RF SCHENKER, S AF HENDERSON, GI ANTONY, A PEREZ, A JOHNSON, RF SCHENKER, S TI FOLATE TRANSPORT BY THE HUMAN PLACENTA - NORMAL TRANSPORT AND ROLE OF SHORT-TERM EXPOSURE TO ETHANOL SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED GASTROINTESTINAL NUTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. INDIANA UNIV,DEPT MED HEMATOL ONCOL,INDIANAPOLIS,IN 46204. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A940 EP A940 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900132 ER PT J AU JENKINS, OR TYDEN, HE FREEMAN, GL AF JENKINS, OR TYDEN, HE FREEMAN, GL TI IMPAIRED RESPONSE TO DOBUTAMINE FOLLOWING A SINGLE BRIEF CORONARY-OCCLUSION IN THE PRESENCE OF FLOW-LIMITING STENOSIS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A965 EP A965 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900267 ER PT J AU LEVINE, SM BRYAN, CL CALHOON, JH ZAMORA, CA ANZUETO, A TRINKLE, JK JENKINSON, SG MURPHY, AL AF LEVINE, SM BRYAN, CL CALHOON, JH ZAMORA, CA ANZUETO, A TRINKLE, JK JENKINSON, SG MURPHY, AL TI REJECTION IN SINGLE LUNG-TRANSPLANT RECIPIENTS WITH PRIMARY PULMONARY-HYPERTENSION RESULTS IN SEVERE VENTILATION PERFUSION MISMATCH SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A984 EP A984 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900369 ER PT J AU MULROW, CD TULEY, MR AGUILAR, C AF MULROW, CD TULEY, MR AGUILAR, C TI SUSTAINED BENEFITS OF HEARING-AIDS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 AUDIE L MURPHY MEM VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A936 EP A936 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900113 ER PT J AU PEACOCK, MD LAWRENCE, RA JENKINSON, SG AF PEACOCK, MD LAWRENCE, RA JENKINSON, SG TI THE EFFECTS OF GAMMA-GLUTAMYL TRANSPEPTIDASE INHIBITION ON GLUTATHIONE PROTECTION FROM HYPERBARIC-OXYGEN SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A957 EP A957 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900226 ER PT J AU PRABHU, SD OROURKE, RA FREEMAN, GL AF PRABHU, SD OROURKE, RA FREEMAN, GL TI THE KINETICS OF DIASTOLIC RESTITUTION IN CLOSED-CHEST DOGS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A965 EP A965 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900270 ER PT J AU SCHENKER, S COBURN, SP MAHUREN, JD JOHNSON, RF HENDERSON, GI AF SCHENKER, S COBURN, SP MAHUREN, JD JOHNSON, RF HENDERSON, GI TI PYRIDOXAL TRANSPORT BY HUMAN PLACENTA - NORMAL TRANSFER AND EFFECTS OF ALCOHOL SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 FT WAYNE STATE DEV CTR,DEPT BIOCHEM,FT WAYNE,IN. UNIV TEXAS,HLTH SCI CTR,DEPT MED GASTROINTESTINAL NUTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1990 VL 38 IS 4 BP A939 EP A939 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EN539 UT WOS:A1990EN53900129 ER PT J AU STOLLER, JK KACMAREK, RM AF STOLLER, JK KACMAREK, RM TI VENTILATORY STRATEGIES IN THE MANAGEMENT OF THE ADULT RESPIRATORY-DISTRESS SYNDROME SO CLINICS IN CHEST MEDICINE LA English DT Review C1 CLEVELAND CLIN FDN,RESPIRATORY THERAPY SECT,CLEVELAND,OH 44195. HARVARD UNIV,SCH MED,DEPT ANESTHESIA,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,RESP CARE,BOSTON,MA 02114. RP STOLLER, JK (reprint author), CLEVELAND CLIN FDN,DEPT PULM DIS,A90,1 CLIN CTR,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. NR 114 TC 37 Z9 38 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0272-5231 J9 CLIN CHEST MED JI Clin. Chest Med. PD DEC PY 1990 VL 11 IS 4 BP 755 EP 772 PG 18 WC Respiratory System SC Respiratory System GA EK281 UT WOS:A1990EK28100013 PM 2269000 ER PT J AU Spiegelman, BM AF Spiegelman, B. M. TI Cell differentiation Editorial overview SO CURRENT OPINION IN CELL BIOLOGY LA English DT Editorial Material C1 [Spiegelman, B. M.] Dana Farber Canc Inst, Boston, MA 02115 USA. RP Spiegelman, BM (reprint author), Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0955-0674 EI 1879-0410 J9 CURR OPIN CELL BIOL JI Curr. Opin. Cell Biol. PD DEC PY 1990 VL 2 IS 6 BP 967 EP 968 DI 10.1016/0955-0674(90)90054-I PG 2 WC Cell Biology SC Cell Biology GA V39FA UT WOS:000209395700001 ER PT J AU Orkin, SH AF Orkin, S. H. TI Cell-specific transcription and cell differentiation in the erythroid lineage SO CURRENT OPINION IN CELL BIOLOGY LA English DT Article C1 [Orkin, S. H.] Childrens Hosp, Div Hematol & Oncol, 300 Longwood Ave, Boston, MA 02115 USA. [Orkin, S. H.] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dana Farber Canc Inst,Dept Pediat, Boston, MA 02115 USA. RP Orkin, SH (reprint author), Childrens Hosp, Div Hematol & Oncol, 300 Longwood Ave, Boston, MA 02115 USA. NR 38 TC 20 Z9 20 U1 1 U2 2 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0955-0674 EI 1879-0410 J9 CURR OPIN CELL BIOL JI Curr. Opin. Cell Biol. PD DEC PY 1990 VL 2 IS 6 BP 1003 EP 1012 DI 10.1016/0955-0674(90)90149-9 PG 10 WC Cell Biology SC Cell Biology GA V39FA UT WOS:000209395700008 PM 1966005 ER PT J AU Wagner, JA Kostyk, SK AF Wagner, J. A. Kostyk, S. K. TI Regulation of neural cell survival and differentiation by peptide growth factors SO CURRENT OPINION IN CELL BIOLOGY LA English DT Article C1 [Wagner, J. A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA USA. [Kostyk, S. K.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA. [Kostyk, S. K.] Dana Farber Canc Inst, Boston, MA 02115 USA. RP Wagner, JA (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA USA. NR 28 TC 14 Z9 14 U1 0 U2 0 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0955-0674 EI 1879-0410 J9 CURR OPIN CELL BIOL JI Curr. Opin. Cell Biol. PD DEC PY 1990 VL 2 IS 6 BP 1050 EP 1057 DI 10.1016/0955-0674(90)90155-8 PG 8 WC Cell Biology SC Cell Biology GA V39FA UT WOS:000209395700014 PM 2099797 ER PT J AU HEDLEYWHYTE, ET AF HEDLEYWHYTE, ET TI DYNAMIC NEUROPATHOLOGY - EDITORIAL OVERVIEW SO CURRENT OPINION IN NEUROLOGY AND NEUROSURGERY LA English DT Article RP HEDLEYWHYTE, ET (reprint author), MASSACHUSETTS GEN HOSP,CHARLES S KUBIK LAB NEUROPATHOL,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CURRENT SCIENCE LTD PI LONDON PA 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB SN 0951-7383 J9 CURR OPIN NEUROL NEU PD DEC PY 1990 VL 3 IS 6 BP 903 EP 905 PG 3 WC Neurosciences SC Neurosciences & Neurology GA EQ224 UT WOS:A1990EQ22400009 ER PT J AU DUKER, JS TOLENTINO, FI AF DUKER, JS TOLENTINO, FI TI RETINOPATHY OF PREMATURITY AND PEDIATRIC RETINA AND VITREOUS DISORDERS SO CURRENT OPINION IN OPHTHALMOLOGY LA English DT Article RP DUKER, JS (reprint author), HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,RETINA ASSOCIATES,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CURRENT SCIENCE PI PHILADELPHIA PA 400 MARKET STREET,SUITE 750 ATTN:SARAH WHEALEN/SUB MGR, PHILADELPHIA, PA 19106 SN 1040-8738 J9 CURR OPIN OPHTHALMOL PD DEC PY 1990 VL 1 IS 6 BP 612 EP 615 PG 4 WC Ophthalmology SC Ophthalmology GA EW281 UT WOS:A1990EW28100009 ER PT J AU RABINOWE, SL AF RABINOWE, SL TI IMMUNOLOGY OF DIABETIC AND POLYGLANDULAR NEUROPATHY SO DIABETES-METABOLISM REVIEWS LA English DT Review RP RABINOWE, SL (reprint author), HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR,IMMUNOL SECT,BOSTON,MA 02115, USA. FU NIAID NIH HHS [R01 AI30987-01] NR 0 TC 32 Z9 32 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0742-4221 J9 DIABETES METAB REV JI Diabetes-Metab. Rev. PD DEC PY 1990 VL 6 IS 3 BP 169 EP 188 PG 20 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA FA074 UT WOS:A1990FA07400003 PM 2091910 ER PT J AU LINDBERG, K RHEINWALD, JG AF LINDBERG, K RHEINWALD, JG TI 3 DISTINCT KERATINOCYTE SUBTYPES IDENTIFIED IN HUMAN ORAL EPITHELIUM BY THEIR PATTERNS OF KERATIN EXPRESSION IN CULTURE AND IN XENOGRAFTS SO DIFFERENTIATION LA English DT Article ID HUMAN EPIDERMAL-CELLS; TERMINAL DIFFERENTIATION; VITAMIN-A; CYTOKERATIN PATTERNS; SQUAMOUS EPITHELIA; ALVEOLAR MUCOSA; ADULT-MOUSE; SKIN; GROWTH; CARCINOMAS AB We have characterized the cells that form the human oral epithelia by analyzing their patterns of keratin expression in culture and in transplants. Keratinocytes of all oral regions synthesized high levels of keratins K5/K14 and K6/K16,K17, as expressed by cells of all stratified squamous epithelia in culture. However, cells from different regions varied in their expression in culture of retinoid-inducible (K19 and K13) and simple epithelial (K7, K8 and K18) keratins. By these criteria, all oral cells could be classified as belonging to one of three intrinsically distinct subtypes: "keratinizing" (gingiva, hard palate), "typical nonkeratinizing" (inner cheek, floor of mouth, ventral tongue) and "special non-keratinizing" (soft palate), all of which differed from the epidermal keratinocyte subtype. Cells from fetal floor of mouth expressed a pattern of keratins in culture markedly different from that of adult floor of mouth cells but identical to that of the adult "special nonkeratinizing" subtype and similar to that of several oral squamous cell carcinoma lines. When cultures of oral keratinocytes were grafted to the dermis of nude mice, they formed stratified epithelial structures after 10 days. In some areas of the stratified structures, the basal layer recapitulated the K19 expression pattern of the oral region from which they had originated. Thus, regional differentiation of the oral epithelium is based on an intrinsic specialization of regional keratinocyte stem cells. Additionally, oral cell transformation either frequently involves reversion to the fetal keratin program or else oral cells that express this keratin program are especially susceptible to transformation. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELL GROWTH & REGULAT,BOSTON,MA 02115. HARVARD UNIV,SCH DENT MED,DEPT ORAL MED & ORAL PATHOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MOLEC & CELLULAR PHYSIOL,BOSTON,MA 02115. NR 56 TC 84 Z9 86 U1 0 U2 2 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-4681 J9 DIFFERENTIATION JI Differentiation PD DEC PY 1990 VL 45 IS 3 BP 230 EP 241 DI 10.1111/j.1432-0436.1990.tb00477.x PG 12 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA EX939 UT WOS:A1990EX93900010 PM 1708735 ER PT J AU BRASIER, AR RON, D TATE, JE HABENER, JF AF BRASIER, AR RON, D TATE, JE HABENER, JF TI A FAMILY OF CONSTITUTIVE C/EBP-LIKE DNA-BINDING PROTEINS ATTENUATE THE IL-1-ALPHA INDUCED, NF-KAPPA-B MEDIATED TRANSACTIVATION OF THE ANGIOTENSINOGEN GENE ACUTE-PHASE RESPONSE ELEMENT SO EMBO JOURNAL LA English DT Article RP BRASIER, AR (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,HOWARD HUGHES MED INST,MOLEC ENDOCRINOL LAB,BOSTON,MA 02114, USA. NR 53 TC 150 Z9 150 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0261-4189 J9 EMBO J JI Embo J. PD DEC PY 1990 VL 9 IS 12 BP 3933 EP 3944 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EK538 UT WOS:A1990EK53800017 PM 2174352 ER PT J AU LEE, CQ YUN, Y HOEFFLER, JP HABENER, JF AF LEE, CQ YUN, Y HOEFFLER, JP HABENER, JF TI CYCLIC-AMP-RESPONSIVE TRANSCRIPTIONAL ACTIVATION OF CREB-327 INVOLVES INTERDEPENDENT PHOSPHORYLATED SUBDOMAINS SO EMBO JOURNAL LA English DT Article DE CREB-327; CYCLIC AMP; PHOSPHORYLATION; PROTEIN KINASE-A; TRANSCRIPTIONAL ACTIVATION ID DEPENDENT PROTEIN-KINASE; GONADOTROPIN-ALPHA-GENE; DNA-BINDING PROTEINS; NUCLEAR FACTOR CREB; FUNCTIONAL-CHARACTERIZATION; SOMATOSTATIN GENE; MAMMALIAN-CELLS; EXPRESSION; ELEMENTS; DISTINCT AB Cyclic AMP-regulated gene expression is mediated by specific phosphoproteins (CREBs) which bind to cAMP-responsive elements of gene promoters. By analyzing the transactivation activities and phosphorylations in vivo of deletion and point mutated chimeric fusion proteins of the placental CREB-327, in which the DNA-binding domain is replaced by heterologous binding-domain of the yeast transcription factor GAL4, we localized the cAMP-responsive and phosphorylated domain to a minimal-essential sequence module of 46 amino acids (residues 92-137). This serine-rich, multiply-phosphorylated sequence consists of at least three interdependent subdomains required for transcriptional activation. Although phosphorylation and serine-119 by cyclic AMP-dependent protein kinase A is necessary for transcriptional activation, such activation requires both a phosphorylated heptadecapeptide domain located ten residues amino terminal to the serine-119 and an eleven-residue domain carboxyl terminal to the serine-119. Deletion of these two domains does not impair phosphorylation of serine-119. Further, deletion of the carboxyl-terminal domain does not alter phosphorylation of the heptadecapeptide domain. We propose that akin to the phosphorylation-dependent activation of enzymes, the transcriptional transactivation functions of CREB-327 involve a phosphorylation-dependent allosteric conformational mechanism. RP LEE, CQ (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,HOWARD HUGHES MED INST,MOLEC ENDOCRINOL LAB,BOSTON,MA 02114, USA. FU NIDDK NIH HHS [DK30457, DK25532] NR 64 TC 228 Z9 229 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0261-4189 J9 EMBO J JI Embo J. PD DEC PY 1990 VL 9 IS 13 BP 4455 EP 4465 PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EN921 UT WOS:A1990EN92100029 PM 2176153 ER PT J AU WILDEY, GM FISCHMAN, AJ MARGOLIES, MN GRAHAM, RM HOMCY, CJ AF WILDEY, GM FISCHMAN, AJ MARGOLIES, MN GRAHAM, RM HOMCY, CJ TI PHOSPHORYLATION STATE OF PROATRIAL NATRIURETIC FACTOR IN RAT ATRIAL SECRETORY GRANULES SO ENDOCRINOLOGY LA English DT Article C1 MASSACHUSETTS GEN HOSP,DIV NUCL MED,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,CELLULAR & MOLEC RES LAB,CARDIAC UNIT,BOSTON,MA 02114. RP WILDEY, GM (reprint author), CLEVELAND CLIN,RES INST,DEPT HEART & HYPERTENS RES,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. FU NHLBI NIH HHS [HL-19259, HL-38070, HL-35642] NR 28 TC 7 Z9 7 U1 0 U2 1 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD DEC PY 1990 VL 127 IS 6 BP 2839 EP 2848 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL108 UT WOS:A1990EL10800029 PM 2174336 ER PT J AU KURIHARA, N GLUCK, S ROODMAN, GD AF KURIHARA, N GLUCK, S ROODMAN, GD TI SEQUENTIAL EXPRESSION OF PHENOTYPE MARKERS FOR OSTEOCLASTS DURING DIFFERENTIATION OF PRECURSORS FOR MULTINUCLEATED CELLS FORMED IN LONG-TERM HUMAN MARROW CULTURES SO ENDOCRINOLOGY LA English DT Article C1 VET ADM MED CTR,RES SER,SAN ANTONIO,TX 78284. VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110. WASHINGTON UNIV,SCH MED,DEPT CELL BIOL,ST LOUIS,MO 63110. WASHINGTON UNIV,SCH MED,DEPT PHYSIOL,ST LOUIS,MO 63110. JEWISH HOSP ST LOUIS,ST LOUIS,MO 63110. FU NIADDK NIH HHS [AM-35188]; NIAMS NIH HHS [AR-32087]; NIDDK NIH HHS [DK-38848] NR 32 TC 57 Z9 57 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD DEC PY 1990 VL 127 IS 6 BP 3215 EP 3221 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL108 UT WOS:A1990EL10800077 PM 1701138 ER PT J AU TENKATE, CI FISCHMAN, AJ RUBIN, RH FUCELLO, AJ RIEXINGER, D WILKINSON, RA DU, L KHAW, BA STRAUSS, HW AF TENKATE, CI FISCHMAN, AJ RUBIN, RH FUCELLO, AJ RIEXINGER, D WILKINSON, RA DU, L KHAW, BA STRAUSS, HW TI EFFECT OF ISOELECTRIC POINT ON BIODISTRIBUTION AND INFLAMMATION - IMAGING WITH INDIUM-111-LABELED IGG SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE LA English DT Article DE INDIUM; IGG; DIETHYLENE TRIAMINE PENTAACETIC ACID; INFECTION; ISOELECTRIC POINT; RADIOLABELED ANTIBODY; BIODISTRIBUTION ID MONOCLONAL-ANTIBODY; IMMUNOGLOBULIN-G; DTPA; CONJUGATION; INFECTION; ANHYDRIDE AB Electrostatic effects play an important role in protein interactions and may alter the biodistribution of antibodies. To study the effect of molecular charge on the biodistribution and infection imaging properties of human polyclonal immunoglobulin G (IgG), its isoelectric point was varied by changing the level of diethylene triamine penta-acetic acid (DTPA) substitution: 0.8, 0.9, 3.7, 5.1 and 5.9 DTPA/IgG. Biodistributions of the different IgG preparations were determined at 10 min, 1, 6, 24, and 48 h post injection in normal rats, and infection imaging properties were determined in rats with Escherichia coli thigh infections. The biodistribution was significantly affected by pI. The immunoglobulin preparations with 0.9 and 3.7 DTPA/IgG showed faster clearance from the circulation and generally lower accumulation in most organs. The images had a target-to-background ratio of approximately 1.3-2.3:1. These results suggest that even though targeting is not affected by the level of DTPA substitutions, preparations with 0.9 and 3.7 DTPA/IgG may be superior imaging agents because of reduced accumulation by background organs. C1 MASSACHUSETTS GEN HOSP,DIV NUCL MED,32 FRUIT ST,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,MED SERV,INFECT DIS UNIT,BOSTON,MA 02114. ROBERT WOOD JOHNSON PHARMACEUT RES INST,RARITAN,NJ. HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. NR 14 TC 18 Z9 18 U1 1 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-6997 J9 EUR J NUCL MED JI Eur. J. Nucl. Med. PD DEC PY 1990 VL 17 IS 6-8 BP 305 EP 309 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EP448 UT WOS:A1990EP44800003 PM 2286203 ER PT J AU KREMER, BK MANKIN, HJ AF KREMER, BK MANKIN, HJ TI A FOLLOW-UP-STUDY OF DANGEROUS ANSWERS IN 4 MEDICAL SPECIALTIES SO EVALUATION & THE HEALTH PROFESSIONS LA English DT Article C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. RP KREMER, BK (reprint author), AMER BOARD MED SPECIALTIES,1 ROTARY CTR,SUITE 805,EVANSTON,IL 60201, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU SAGE SCIENCE PRESS PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0163-2787 J9 EVAL HEALTH PROF JI Eval. Health Prof. PD DEC PY 1990 VL 13 IS 4 BP 489 EP 503 DI 10.1177/016327879001300409 PG 15 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA EJ264 UT WOS:A1990EJ26400009 ER PT J AU DELCASTILLO, CF WARSHAW, AL AF DELCASTILLO, CF WARSHAW, AL TI DIAGNOSIS AND PREOPERATIVE EVALUATION OF PANCREATIC-CANCER, WITH IMPLICATIONS FOR MANAGEMENT SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article C1 MASSACHUSETTS GEN HOSP,ACC 336,15 PARKMAN ST,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 92 TC 7 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1990 VL 19 IS 4 BP 915 EP 933 PG 19 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EL330 UT WOS:A1990EL33000011 ER PT J AU MERCOLA, M DEININGER, PL SHAMAH, SM PORTER, J WANG, CY STILES, CD AF MERCOLA, M DEININGER, PL SHAMAH, SM PORTER, J WANG, CY STILES, CD TI DOMINANT-NEGATIVE MUTANTS OF A PLATELET-DERIVED GROWTH-FACTOR GENE SO GENES & DEVELOPMENT LA English DT Article DE MOUSE PDGF-A CDNA CLONE; PDGF-AA HOMODIMERS; XENOPUS; PDGF-A ID FACTOR-A-CHAIN; SIMIAN SARCOMA-VIRUS; V-SIS GENE; PDGF RECEPTOR; DIFFERENT ISOFORMS; HUMAN-FIBROBLASTS; B-CHAIN; EXPRESSION; RNA; IDENTIFICATION AB Using site-directed mutagenesis of a PDGF-A cDNA clone, we identify two domains that are required to generate stable, mitogenically active PDGF-AA homodimers. Alteration of the tetra-basic amino acid sequence (Arg84-Arg-Lys-Arg to Arg-Ser-Asn-Gly) results in the formation of stable pro-PDGF-A homodimers that lack mitogenic activity. Substitution of serine for Cys129 destablizes PDGF-A subunits within the cell. Genes incorporating either the processing lesion or the cysteine substitution suppress wild-type PDGF-A gene expression in a trans-dominant fashion. Suppression occurs because the mutant PDGF subunits dimerize with wild-type subunits to form inactive or unstable heterodimers. Suppression is exerted across phylogenetic boundaries; thus, the mouse PDGF-A chain mutants inhibit the activity of the wild-type Xenopus PDGF-A. The cysteine mutant gene suppresses expression of PDGF-B (c-sis), as well as PDGF-A. The processing mutant gene, however, suppresses only PDGF-A. Dominant-negative mutations of PDGF and other growth factors which, like PDGF, function as dimers may prove useful for creating animal models of growth factor deficiency disease states and for revealing the function of growth factors during early embryonic development. C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. LOUISIANA STATE UNIV,MED CTR,DEPT BIOCHEM & MOLEC BIOL,NEW ORLEANS,LA 70112. ALTON OCHSNER MED FDN & OCHSNER CLIN,MOLEC GENET LAB,NEW ORLEANS,LA 70121. RP MERCOLA, M (reprint author), HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115, USA. OI Deininger, Prescott/0000-0002-1067-3028 NR 46 TC 55 Z9 55 U1 0 U2 0 PU COLD SPRING HARBOR LAB PRESS PI PLAINVIEW PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 SN 0890-9369 J9 GENE DEV JI Genes Dev. PD DEC PY 1990 VL 4 IS 12B BP 2333 EP 2341 DI 10.1101/gad.4.12b.2333 PG 9 WC Cell Biology; Developmental Biology; Genetics & Heredity SC Cell Biology; Developmental Biology; Genetics & Heredity GA EQ624 UT WOS:A1990EQ62400010 PM 2279701 ER PT J AU SCHULTES, NP SZOSTAK, JW AF SCHULTES, NP SZOSTAK, JW TI DECREASING GRADIENTS OF GENE CONVERSION ON BOTH SIDES OF THE INITIATION SITE FOR MEIOTIC RECOMBINATION AT THE ARG4 LOCUS IN YEAST SO GENETICS LA English DT Article RP SCHULTES, NP (reprint author), MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114, USA. NR 32 TC 76 Z9 78 U1 2 U2 2 PU GENETICS PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 SN 0016-6731 J9 GENETICS JI Genetics PD DEC PY 1990 VL 126 IS 4 BP 813 EP 822 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA EL334 UT WOS:A1990EL33400004 PM 1981763 ER PT J AU KAUFMAN, DL RAMESH, V MCCLATCHEY, AI MENKES, JH TOBIN, AJ AF KAUFMAN, DL RAMESH, V MCCLATCHEY, AI MENKES, JH TOBIN, AJ TI DETECTION OF POINT MUTATIONS ASSOCIATED WITH GENETIC-DISEASES BY AN EXON SCANNING TECHNIQUE SO GENOMICS LA English DT Article C1 UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,DEPT PEDIAT,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024. MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,GENET UNIT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02114. FU NINDS NIH HHS [NS 20198, NS 22256, NS 20356] NR 17 TC 13 Z9 13 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0888-7543 J9 GENOMICS JI Genomics PD DEC PY 1990 VL 8 IS 4 BP 656 EP 663 DI 10.1016/0888-7543(90)90252-P PG 8 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA EL475 UT WOS:A1990EL47500007 PM 2276738 ER PT J AU LIEBER, CS DECARLI, LM MAK, KM KIM, CI LEO, MA AF LIEBER, CS DECARLI, LM MAK, KM KIM, CI LEO, MA TI ATTENUATION OF ALCOHOL-INDUCED HEPATIC-FIBROSIS BY POLYUNSATURATED LECITHIN SO HEPATOLOGY LA English DT Article ID CHRONIC ETHANOL-CONSUMPTION; ESSENTIAL FATTY-ACIDS; LIVER-INJURY; RAT-LIVER; INTESTINAL-ABSORPTION; TRANSITIONAL CELLS; AMINO-ACIDS; CIRRHOSIS; PHOSPHOLIPIDS; BABOON AB Characteristic features of alcoholic liver injury include fibrosis and striking membrane alterations, with associated phospholipid changes. To offset some of these abnormalities, a 10-yr study was conducted in baboons: 12 animals (eight females, four males) were fed a liquid diet supplemented with polyunsaturated lecithin (4.1 mg/kcal) for up to 8 yr, with either ethanol (50% of total energy) or isocaloric carbohydrate. They were compared with another group of 18 baboons fed an equivalent amount of the same diet (with or without ethanol), but devoid of lecithin. In the two groups, comparable increases in lipids developed in the ethanol-fed animals, but striking differences in the degree of fibrosis were seen. Whereas at least septal fibrosis (with cirrhosis in two) and transformation of their lipocytes into transitional cells developed in seven of the nine baboons fed the regular diet with ethanol, septal fibrosis did not develop in any animals fed lecithin (p < 0.005). They did not progress beyond the stage of perivenular fibrosis (sometimes associated with pericellular and perisinusoidal fibrosis) and had a significantly lesser activation of lipocytes to transitional cells. Furthermore, when three of these animals were taken off lecithin, but continued on the same amount of the ethanol-containing diet, they rapidly (within 18 to 21 mo) progressed to cirrhosis, accompanied by an increased transformation of their lipocytes to transitional cells. These results indicate that some component of lecithin exerts a protective action against the fibrogenic effects of ethanol. Because we have previously found the choline, in amounts present in lecithin, has no comparable action, the polyunsaturated phospholipids themselves might be responsible for the protective effect. C1 CUNY MT SINAI SCH MED,NEW YORK,NY 10029. RP LIEBER, CS (reprint author), BRONX VET AFFAIRS MED CTR,CTR ALCOHOL RES & TREATMENT 151-G,LIVER DIS & NUTR SECT,BRONX,NY 10468, USA. FU NIAAA NIH HHS [AA03508]; NIDDK NIH HHS [DK32810] NR 79 TC 120 Z9 123 U1 2 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD DEC PY 1990 VL 12 IS 6 BP 1390 EP 1398 DI 10.1002/hep.1840120621 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EQ625 UT WOS:A1990EQ62500020 PM 2258155 ER PT J AU SCHNENKER, S KAHN, SA AF SCHNENKER, S KAHN, SA TI HEPATOLOGY - WHAT A DIFFERENCE A DECADE MAKES SO HEPATOLOGY LA English DT Editorial Material C1 AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. AMER ASSOC STUDY LIVER DIS,SAN ANTONIO,TX 78284. RP SCHNENKER, S (reprint author), UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD DEC PY 1990 VL 12 IS 6 BP 1436 EP 1439 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EQ625 UT WOS:A1990EQ62500026 ER PT J AU ROSENBAUM, JF AF ROSENBAUM, JF TI SWITCHING PATIENTS FROM ALPRAZOLAM TO CLONAZEPAM SO HOSPITAL AND COMMUNITY PSYCHIATRY LA English DT Article C1 HARVARD UNIV,SCH MED,PSYCHIAT,BOSTON,MA 02115. RP ROSENBAUM, JF (reprint author), MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,15 PARKMAN ST,WACC 815,BOSTON,MA 02114, USA. NR 6 TC 4 Z9 4 U1 0 U2 1 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0022-1597 J9 HOSP COMMUNITY PSYCH PD DEC PY 1990 VL 41 IS 12 BP 1302 EP & PG 0 WC Public, Environmental & Occupational Health; Psychiatry SC Public, Environmental & Occupational Health; Psychiatry GA EK932 UT WOS:A1990EK93200004 PM 2276722 ER PT J AU FLOTTE, TJ AF FLOTTE, TJ TI MALIGNANT-MELANOMA INSITU SO HUMAN PATHOLOGY LA English DT Article DE MELANOMA; CRITERIA; DYSPLASIA; INSITU ID TUMOR PROGRESSION; HUMAN MELANOCYTES C1 MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. RP FLOTTE, TJ (reprint author), MASSACHUSETTS GEN HOSP,DEPT DERMATOL,BOSTON,MA 02114, USA. NR 13 TC 9 Z9 10 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD DEC PY 1990 VL 21 IS 12 BP 1199 EP 1201 DI 10.1016/S0046-8177(06)80030-4 PG 3 WC Pathology SC Pathology GA EQ062 UT WOS:A1990EQ06200003 PM 2249832 ER PT J AU TRON, VA BARNHILL, RL MIHM, MC AF TRON, VA BARNHILL, RL MIHM, MC TI MALIGNANT-MELANOMA INSITU - FUNCTIONAL CONSIDERATIONS OF CANCER SO HUMAN PATHOLOGY LA English DT Article DE MALIGNANT MELANOMA; INSITU, MONOCLONAL ANTIBODIES; KARYOTYPE; MOLECULAR GENETICS ID TUMOR PROGRESSION; HUMAN MELANOCYTES; NODULAR MELANOMA; DYSPLASTIC NEVI; METASTASES; EXPRESSION; RECEPTOR; LESIONS; CELLS C1 MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. NR 22 TC 11 Z9 11 U1 2 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD DEC PY 1990 VL 21 IS 12 BP 1202 EP 1205 DI 10.1016/S0046-8177(06)80031-6 PG 4 WC Pathology SC Pathology GA EQ062 UT WOS:A1990EQ06200004 PM 2135386 ER PT J AU SHOCKLEY, TR MANDEVILLE, JT TOMPKINS, RG YARMUSH, ML AF SHOCKLEY, TR MANDEVILLE, JT TOMPKINS, RG YARMUSH, ML TI EQUILIBRIUM BINDING CHARACTERISTICS OF MONOCLONAL-ANTIBODIES RECOGNIZING MELANOMA CELL-SURFACE ANTIGENS SO HYBRIDOMA LA English DT Article ID HUMAN-MALIGNANT-MELANOMA; HUMAN-TUMOR XENOGRAFTS; CARCINOEMBRYONIC ANTIGEN; NUDE-MICE; PROTEOGLYCAN; GROWTH; RADIOIMMUNODETECTION; GLYCOPROTEIN; GANGLIOSIDE; ASSAYS AB The equilibrium binding characteristics of a panel of six monoclonal antibodies (MAb) recognizing melanoma cell surface antigens (125 kdal cell surface melanoma associated glycoprotein antigen, 125kD-MAA; high molecular weight melanoma associated antigen, HMW-MAA; and a non-protein melanoma associated antigen, NP-MAA) were investigated using the cell lines SK-MEL-2, SK-MEL-5, and M21. The MAbs displayed equilibrium association constant (K) values ranging from 10(7) M-1 to 10(10) M-1 and maximum MAb binding values (Q(max)) from 2 x 10(4) to 2 x 10(6) MAb molecules bound per cell. High trypsin concentrations were shown to have deleterious effects on Q(max) values obtained for antibodies recognizing the 125kD-MAA, and even low trypsin concentrations affected Q(max) values obtained for MAbs recognizing the HMW-MAA (although a complete linear recovery of HMW-MAA antigen was observed in 20-25 hours). Significant changes in Q(max) were also noted for different cell passages. Except for MAb 43.2, little variation in K was observed when different cell lines were used. Linear Scatchard plots were obtained for all MAbs except 43.2 in which case concave down behavior was observed suggesting the existence of positive cooperativity between the binding sites of this MAb. C1 MASSACHUSETTS GEN HOSP,DEPT SURG,SURG SERV,WANG ACC SUITE 464,15 PARKMAN ST,BOSTON,MA 02114. MIT,DEPT CHEM ENGN,CAMBRIDGE,MA 02139. RUTGERS STATE UNIV,DEPT CHEM & BIOCHEM ENGN,PISCATAWAY,NJ 08854. RUTGERS STATE UNIV,CTR ADV BIOTECHNOL & MED,PISCATAWAY,NJ 08854. NR 58 TC 8 Z9 8 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0272-457X J9 HYBRIDOMA JI Hybridoma PD DEC PY 1990 VL 9 IS 6 BP 527 EP 544 DI 10.1089/hyb.1990.9.527 PG 18 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA ER303 UT WOS:A1990ER30300002 PM 2076895 ER PT J AU BIRNGRUBER, R AF BIRNGRUBER, R TI INTRODUCTION TO THE SPECIAL ISSUE ON LASERS IN BIOLOGY AND MEDICINE SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Editorial Material C1 UNIV MUNICH,DEPT OPHTHALMOL,W-8000 MUNICH 2,GERMANY. RP BIRNGRUBER, R (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN RES LABS PHOTOMED,BOSTON,MA 02114, USA. RI Birngruber, Reginald/Q-2342-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2146 EP 2147 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900015 ER PT J AU CHEONG, WF PRAHL, SA WELCH, AJ AF CHEONG, WF PRAHL, SA WELCH, AJ TI A REVIEW OF THE OPTICAL-PROPERTIES OF BIOLOGICAL TISSUES SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Review ID SCATTERING PHASE FUNCTIONS; PHOTODYNAMIC THERAPY; LIGHT DOSIMETRY; DIFFUSION-APPROXIMATION; TURBID MEDIA; HUMAN-BRAIN; LASER; DISTRIBUTIONS; ABSORPTION; TRANSPORT AB A comprehensive compilation of published optical properties (absorption, scattering, total attenuation, effective attenuation, and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths is presented. The theoretical foundations for most experimental approaches are outlined. Relations between Kubelka-Munk parameters and transport coefficients are listed. The optical properties of aorta, liver, and muscle at 633 nm are discussed in detail. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. UNIV TEXAS,DEPT ELECT & COMP ENGN,AUSTIN,TX 78712. UNIV TEXAS,BIOMED ENGN PROGRAM,AUSTIN,TX 78712. NR 86 TC 1718 Z9 1772 U1 22 U2 211 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2166 EP 2185 DI 10.1109/3.64354 PG 20 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900019 ER PT J AU LAMURAGLIA, GM PRINCE, MR NISHIOKA, NS OBREMSKI, S BIRNGRUBER, R AF LAMURAGLIA, GM PRINCE, MR NISHIOKA, NS OBREMSKI, S BIRNGRUBER, R TI OPTICAL-PROPERTIES OF HUMAN ARTERIAL THROMBUS, VASCULAR GRAFTS, AND SUTURES - IMPLICATIONS FOR SELECTIVE LASER THROMBUS ABLATION SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID BYPASS GRAFTS; ANGIOPLASTY; ABSORPTION AB To determine the optimal wavelength for laser ablation of arterial and graft thrombus, an integrating sphere was used to obtain optical measurements from different depths of abdominal aortic aneurysm thrombi, vascular grafts, and vascular sutures. Arterial thrombus of all depths maintained the wavelength profile of oxyhemoglobin absorption; the magnitude of the absorption coefficient, however, varied with the thrombus depth or age. White vascular materials demonstrated little variation in spectral absorption coefficients. When dyes were present, the suture's spectral absorption coefficients varied with the dye utilized and the product manufacturer. The nadir of absorption was in the 450-500 nm waveband consistent with their blue-green color. A simple thermal model was used as an indicator for the radiant exposure (energy/area) that could cause vascular material dehiscence or arterial thrombus ablation. We conclude that although there are several wavelengths that could be utilized for the ablation of arterial thrombus, primarily the 410 nm and to a lesser extent the 450-500 nm waveband provides the best selectivity since it has the best calculated energy of ablation ratios of thrombus to the commonly used vascular materials studied. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,BOSTON,MA 02114. RP LAMURAGLIA, GM (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT VASC SURG,BOSTON,MA 02114, USA. RI Birngruber, Reginald/Q-2342-2016 NR 25 TC 6 Z9 6 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2200 EP 2206 DI 10.1109/3.64356 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900021 ER PT J AU VOGEL, A SCHWEIGER, P FRIESER, A ASIYO, MN BIRNGRUBER, R AF VOGEL, A SCHWEIGER, P FRIESER, A ASIYO, MN BIRNGRUBER, R TI INTRAOCULAR ND-YAG LASER-SURGERY - LIGHT TISSUE INTERACTION, DAMAGE RANGE, AND REDUCTION OF COLLATERAL EFFECTS SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID ACOUSTIC TRANSIENT GENERATION; PICOSECOND OPTICAL-BREAKDOWN; Q-SWITCHED NEODYMIUM; POSTERIOR CAPSULOTOMY; CORNEAL ENDOTHELIUM; CAVITATION BUBBLES; RETINAL-DETACHMENT; SOLID BOUNDARY; SHOCK-WAVES; PRESSURE AB The working and damage mechanisms of intraocular Nd: YAG laser surgery and their respective damage ranges were investigated in vitro using bovine cornea specimens as a model tissue. The main mechanisms are plasma formation and expansion, emission of acoustic transients, and cavitation with jet formation. When a sequence of laser pulses is applied, the interaction of the acoustic transients with gas bubbles remaining from preceding laser exposures is also important. To distinguish the effects caused by the different physical mechanisms, laser pulses were aimed directly onto the corneal endothelium, through the cornea, and parallel to the cornea at various distances. Simultaneously, the cavitation bubble size was determined. The surface morphology and sections of the same lesions were studied by light and electron microscopy. The primary surgical mechanism is tissue evaporation by the laser plasma, whereas the collateral damage from single laser pulses is mainly caused by the cavitation and jet formation. The damage range after a 4 mJ laser pulse is 0.8 mm, which is slightly larger than the corresponding cavitation bubble radius. The damage range of the acoustic transients produced by a 4 mJ laser pulse is several millimeters, when they can interact with small gas bubbles attached to the corneal endothelium. The damage range of the acoustic transients alone is smaller than that of cavitation as far as damage detected by light and scanning electron microscopy is concerned. However, on a subcellular level the acoustic transients may possibly cause damage up to a much larger distance. The damage range observed varies with the cube root of the laser pulse energy. A reduction of collateral effects therefore requires the use of small pulse energies. For energies of less than 1 mJ, the pulse duration has to be reduced to ensure plasma production. It is proposed to use low-energy picosecond pulses with moderate repetition rate instead of single nanosecond pulses to reduce collateral damage effects. C1 UNIV MUNICH,HOSP EYE,DEPT HISTOPATHOL,MUNICH 2,GERMANY. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. KENYATTA NATL HOSP,NAIROBI,KENYA. RP VOGEL, A (reprint author), UNIV MUNICH,HOSP EYE,HERMANN WACKER LAB MED LASER APPLICAT,MUNICH 2,GERMANY. RI Vogel, Alfred/D-9852-2011; Birngruber, Reginald/Q-2342-2016 NR 81 TC 152 Z9 158 U1 1 U2 15 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2240 EP 2260 DI 10.1109/3.64361 PG 21 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900026 ER PT J AU NISHIOKA, NS DOMANKEVITZ, Y AF NISHIOKA, NS DOMANKEVITZ, Y TI COMPARISON OF TISSUE ABLATION WITH PULSED HOLMIUM AND THULIUM LASERS SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID THERMAL-DAMAGE; ER-YAG; IRRADIATION; DELIVERY; DURATION; SYSTEM AB The ablation rates and tissue effects produced by a pulsed holmium laser (wavelength 2.12-mu-m, pulse duration 250-mu-s) and a pulsed thulium laser (wavelength 2.01-mu-m, pulse duration 250-mu-s) were compared. Because the absorption coefficient of water is almost three times greater at the shorter wavelength (65 versus 24 cm-1, the thulium laser should have a significantly lower threshold of ablation and produce significantly less residual thermal injury. These hypotheses were tested in vitro. Ablation rates were measured using fresh liver and a mass loss technique and found to increase linearly with delivered radiant exposure. The threshold radiant exposure for ablation was derived from the mass loss measurements and found to be 36 J/cm3 for the holmium laser and 29 J/cm2 for the thulium laser. The corresponding heats of ablation were 10 kJ/cm3 for the holmium laser and 9.7 kJ/cm3 for the thulium laser. These values were not statistically different. Ablation craters were made in freshly excised guinea pig skin and examined microscopically. The thulium laser produced slightly smaller zones of thermal residual injury but more than predicted by theory. When used for tissue ablation, the holmium and thulium lasers are comparable. C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. MIT,DIV HLTH SCI & TECHNOL,CAMBRIDGE,MA 02139. RP NISHIOKA, NS (reprint author), MASSACHUSETTS GEN HOSP,WELLMAN RES LABS PHOTOMED,BOSTON,MA 02114, USA. NR 26 TC 41 Z9 41 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2271 EP 2275 DI 10.1109/3.64363 PG 5 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900028 ER PT J AU DOMANKEVITZ, Y NISHIOKA, NS AF DOMANKEVITZ, Y NISHIOKA, NS TI MEASUREMENT OF LASER ABLATION THRESHOLD WITH A HIGH-SPEED FRAMING CAMERA SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID PULSED HOLMIUM LASER; TISSUE ABLATION; ANGIOPLASTY AB A method for measuring laser ablation threshold energy with a high-speed framing camera is presented. To demonstrate the utility of the technique, the threshold energy for pulsed holmium laser ablation of liver was measured. The measured threshold radiant exposure of 30 +/- 3 J/cm2 is in good agreement with values previously determined by alternate techniques. In addition to providing a rapid and reproducible measurement of laser ablation threshold, this technique also provides insight into the physical mechanisms of ablation. C1 MIT,DIV HLTH SCI & TECHNOL,CAMBRIDGE,MA 02139. MASSACHUSETTS GEN HOSP,GASTROINTESTINAL UNIT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RP DOMANKEVITZ, Y (reprint author), MASSACHUSETTS GEN HOSP,WELLMAN LABS PHOTOMED,BOSTON,MA 02114, USA. NR 15 TC 9 Z9 11 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2276 EP 2278 DI 10.1109/3.64364 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900029 ER PT J AU GREGORY, KW ANDERSON, RR AF GREGORY, KW ANDERSON, RR TI LIQUID CORE LIGHT GUIDE FOR LASER ANGIOPLASTY SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article RP GREGORY, KW (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114, USA. NR 5 TC 16 Z9 16 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2289 EP 2296 DI 10.1109/3.64367 PG 8 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900032 ER PT J AU PRINCE, MR LAMURAGLIA, GM SEIDLITZ, CE PRAHL, SA ATHANASOULIS, CA BIRNGRUBER, R AF PRINCE, MR LAMURAGLIA, GM SEIDLITZ, CE PRAHL, SA ATHANASOULIS, CA BIRNGRUBER, R TI BALL-TIPPED FIBERS FOR LASER ANGIOPLASTY WITH THE PULSED-DYE LASER SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID PERIPHERAL VASCULAR-DISEASE; ATHEROSCLEROTIC PLAQUE; SELECTIVE ABLATION; ABSORPTION; RADIATION; DELIVERY; INJURY; PROBE AB A method of introducing high-intensity laser radiation into arteries has been developed and tested in amputated human limbs. The device consists of a small diameter, flexible, quartz optical fiber which tapers to a large diameter, smooth, rounded ball-tip. The smooth, ball-tip minimizes the chance of mechanical dissection or perforation of the vessel wall. The spot size can be varied over a large range by varying the fiber input coupling, taper length, and numerical aperture. With 480 nm radiation, which is preferentially absorbed by atherosclerotic plaque and thrombus, at 8-mu-s pulse durations, the device effectively recanalized occluded human peripheral arteries creating a 2-3 mm diameter channel. The radiant exposure required to recanalized arteries (85 J/cm2) was higher than the ablation threshold for plaque (56 J/cm2), but well below the fluence required to ablate normal artery and perforate (226 J/cm2). Time-delayed, flash photography demonstrates formation of a large vapor bubble with each ablative pulse which suggests that laser recanalization can involve not only ablating plaque but also an expanding effect similar to balloon angioplasty. These data demonstrate that a tapered ball-tipped fiber can deliver the high-intensity 480 nm radiation required for selective ablation of plaque and this device can effectively recanalize symptomatic peripheral artery occlusions. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT VASC SURG,BOSTON,MA 02114. RP PRINCE, MR (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL,BOSTON,MA 02114, USA. RI Birngruber, Reginald/Q-2342-2016 NR 29 TC 8 Z9 8 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2297 EP 2304 DI 10.1109/3.64368 PG 8 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900033 ER PT J AU REN, QS BIRNGRUBER, R AF REN, QS BIRNGRUBER, R TI AXICON - A NEW LASER-BEAM DELIVERY SYSTEM FOR CORNEAL SURGERY SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID EXCIMER LASER; PHOTOREFRACTIVE KERATECTOMY AB A new laser beam delivery system using axicon beam shaping has been designed to produce a controllable surface ablation as well as trephination for the corneal surgery. Noncontact cornea trephination was performed on human eye-bank eyes by using a Q-switched Er: YAG laser with an axicon-lens combination. The results shows that the uniformity of the trephination along the ring depends on the the radial symmetry of the beam. The histological results of the samples show the damage zone of the laser cut is less than 10-mu-m. This demonstrated the possibility of replacement of the mechanical trephination in corneal surgery. RP REN, QS (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114, USA. RI Ren, Qiushi/D-1451-2012; Birngruber, Reginald/Q-2342-2016 NR 21 TC 25 Z9 25 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 1990 VL 26 IS 12 BP 2305 EP 2308 DI 10.1109/3.64369 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA EY439 UT WOS:A1990EY43900034 ER PT J AU WODICKA, GR STEVENS, KN GOLUB, HL SHANNON, DC AF WODICKA, GR STEVENS, KN GOLUB, HL SHANNON, DC TI SPECTRAL CHARACTERISTICS OF SOUND-TRANSMISSION IN THE HUMAN RESPIRATORY SYSTEM SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING LA English DT Article AB The amplitude of sound transmission from the mouth to a site overlying the extrathoracic trachea and two sites on the right posterior chest wall over the 100-600 Hz frequency range was measured in eight healthy adult subjects. An acoustic driver and a rigid tube were employed to introduce sound into the mouths of the subjects at resting lung volume, and the transmission measurements were performed using lightweight accelerometers. Similar spectral characteristics of acceleration were observed in all of the subjects showing peaks in the transmission. These characteristics included 1) two regions of increased transmission over the frequency range of the measurements 2) a decrease in the magnitude of acceleration of the chest wall as compared to the tracheal site of roughly 20 dB at lower frequencies, 3) a strong trend of decreasing acceleration of the chest wall with increasing frequency. These spectra agreed favorably with the predictions of a theoretical model of the acoustical properties of the respiratory system [1]. The model suggests the primary structural determinants of a number of the observed characteristics including the importance of the lung parenchyma in sound attenuation. C1 PURDUE UNIV,HILLENBRAND BIOMED ENGN CTR,W LAFAYETTE,IN 47907. PEDIAT DIAGNOST SERV INC,CAMBRIDGE,MA 02142. MASSACHUSETTS GEN HOSP,CHILDRENS SERV,PEDIAT PULM UNIT,BOSTON,MA 02114. MIT,DEPT ELECT ENGN & COMP SCI,CAMBRIDGE,MA 02139. RP WODICKA, GR (reprint author), PURDUE UNIV,SCH ELECT ENGN,W LAFAYETTE,IN 47907, USA. NR 7 TC 38 Z9 40 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9294 J9 IEEE T BIO-MED ENG JI IEEE Trans. Biomed. Eng. PD DEC PY 1990 VL 37 IS 12 BP 1130 EP 1135 DI 10.1109/10.64455 PG 6 WC Engineering, Biomedical SC Engineering GA ER312 UT WOS:A1990ER31200002 PM 2289787 ER PT J AU PEARLMAN, JD LEAVITT, M NEWELL, JB AF PEARLMAN, JD LEAVITT, M NEWELL, JB TI A-PRIORI INFORMATION IN IMAGE-ANALYSIS - ASSESSMENT OF INTENSITY DISTRIBUTION FOR DEFINITION OF SHAPE AND SIZE OF SMALL VESSELS SO IEEE TRANSACTIONS ON MEDICAL IMAGING LA English DT Letter AB A method for incorporation of a prior information in computer-based image analysis is described and critically evaluated. The specific application improves pixel resolution (spot size) and shape estimation of small vessel cross-sections in exchange for dynamic range information. The potential subpixel spot size sensitivity for a 16 bit gray scale is better than one part in 32 000. Performance of shape recovery is assessed in relation to signal-to-noise ratio, acquired image resolution, vessel shape complexity and aspect ratio. The process is shown to be effective and stable when signal-to-noise ratio exceeds 10, when the number of pixels across the vessel is 2 or more, when the vessel contour has as many as 6 lobes and the aspect ratio is in the range 0.2-5.0. RP PEARLMAN, JD (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,CTR CARDIAC COM,BOSTON,MA 02114, USA. NR 11 TC 5 Z9 5 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0278-0062 J9 IEEE T MED IMAGING JI IEEE Trans. Med. Imaging PD DEC PY 1990 VL 9 IS 4 BP 461 EP 465 DI 10.1109/42.61762 PG 5 WC Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Engineering; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging GA EU057 UT WOS:A1990EU05700012 PM 18222794 ER PT J AU AUCHINCLOSS, H AF AUCHINCLOSS, H TI TRANSPLANTATION OF DISCORDANT XENOGRAFTS - A REVIEW OF PROGRESS - COMMENT SO IMMUNOLOGY TODAY LA English DT Letter ID SURVIVAL; XENOTRANSPLANTATION; RAT RP AUCHINCLOSS, H (reprint author), MASSACHUSETTS GEN HOSP,DEPT SURG,BOSTON,MA 02114, USA. NR 9 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0167-5699 J9 IMMUNOL TODAY JI Immunol. Today PD DEC PY 1990 VL 11 IS 12 BP 456 EP 457 DI 10.1016/0167-5699(90)90175-9 PG 2 WC Immunology SC Immunology GA EN940 UT WOS:A1990EN94000012 ER PT J AU EPSTEIN, J LEE, MM KELLY, CE DONAHOE, PK AF EPSTEIN, J LEE, MM KELLY, CE DONAHOE, PK TI EFFECT OF ESCHERICHIA-COLI ENDOTOXIN ON MAMMALIAN-CELL GROWTH AND RECOMBINANT PROTEIN-PRODUCTION SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY LA English DT Letter ID HUMAN INVITRO FERTILIZATION; TUMOR NECROSIS FACTOR; ENDOTHELIAL-CELLS; TISSUE FACTOR; EXPRESSION; INJURY C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP EPSTEIN, J (reprint author), MASSACHUSETTS GEN HOSP,PEDIAT SURG RES LAB,BOSTON,MA 02114, USA. NR 21 TC 7 Z9 7 U1 0 U2 2 PU SOC IN VITRO BIOLOGY PI COLUMBIA PA 8815 CENTRE PARK DRIVE SUITE 210, COLUMBIA, MD 21045 SN 0073-5655 J9 IN VITRO CELL DEV B PD DEC PY 1990 VL 26 IS 12 BP 1121 EP 1122 PG 2 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA EZ244 UT WOS:A1990EZ24400004 PM 2079460 ER PT J AU UITVLUGT, A AF UITVLUGT, A TI MANAGING COMPLICATIONS OF EPIDURAL ANALGESIA SO INTERNATIONAL ANESTHESIOLOGY CLINICS LA English DT Article C1 CAMBRIDGE HOSP,DEPT ANESTHESIOL,CAMBRIDGE,MA 02139. MASSACHUSETTS GEN HOSP,DEPT ANESTHESIOL,BOSTON,MA 02114. RP UITVLUGT, A (reprint author), CAMBRIDGE HOSP,DEPT ANESTHESIA,CAMBRIDGE,MA 02139, USA. NR 14 TC 5 Z9 6 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0020-5907 J9 INT ANESTHESIOL CLIN JI Int. Anesthesiol. Clin. PD WIN PY 1990 VL 28 IS 1 BP 11 EP 16 DI 10.1097/00004311-199002810-00003 PG 6 WC Anesthesiology SC Anesthesiology GA CH677 UT WOS:A1990CH67700003 PM 2403984 ER PT J AU AUSTIN, KL PALMER, JR SEDDON, JM GLYNN, RJ ROSENBERG, L GRAGOUDAS, ES KAUFMAN, DW SHAPIRO, S AF AUSTIN, KL PALMER, JR SEDDON, JM GLYNN, RJ ROSENBERG, L GRAGOUDAS, ES KAUFMAN, DW SHAPIRO, S TI CASE-CONTROL STUDY OF IDIOPATHIC RETINAL-DETACHMENT SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Article ID EPIDEMIOLOGY; RISK AB A case-control study of idiopathic, rhegmatogenous retinal detachment (IRD) was conducted to investigate potential risk factors for developing IRD. These included some factors reported previously, such as cardiovascular disease, and some not under suspicion, such as cigarette smoking and iris colour. Cases (n = 198) were incident cases of IRD who were hospitalized for surgical repair of their detachments. Controls (n = 655) were patients hospitalized for conditions unrelated to suspected risk factors for IRD. The risk of IRD appeared to increase with increasing age, and the relative risk for self-reported myopes, compared with non-myopes, was elevated (RR = 3.4, 95% Cl = 2.3 - 5.0). The relative risk of IRD was decreased in current smokers (RR = 0.5, 95% Cl = 0.3 - 0.8); although there was not a significant trend of decreasing relative risk with increasing amount smoked, the estimate was lowest in those who smoked most heavily. Risk did not appear to be related to gender, eye colour, history of myocardial infraction, or history of hypertension. C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,DEPT OPHTHALMOL,EPIDEMIOL UNIT,243 CHARLES ST,BOSTON,MA 02114. BOSTON UNIV,SCH MED,SCH PUBL HLTH,SLONE EPIDEMIOL UNIT,BROOKLINE,MA. FU FDA HHS [FD-U-000082, U01-FD-01222] NR 25 TC 23 Z9 25 U1 0 U2 1 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0300-5771 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD DEC PY 1990 VL 19 IS 4 BP 1045 EP 1050 DI 10.1093/ije/19.4.1045 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA ET595 UT WOS:A1990ET59500039 PM 2083988 ER PT J AU LANDRY, J TEPPER, JE WOOD, WC MOULTON, EO KOERNER, F SULLINGER, J AF LANDRY, J TEPPER, JE WOOD, WC MOULTON, EO KOERNER, F SULLINGER, J TI PATTERNS OF FAILURE FOLLOWING CURATIVE RESECTION OF GASTRIC-CARCINOMA SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE GASTRIC CANCER; PATTERNS OF FAILURE; CURATIVE SURGERY ID THERAPY; STOMACH; CANCER AB To identify patterns of failure following curative resection of gastric carcinoma, the records of 130 patients undergoing resection with curative intent at the Massachusetts General Hospital were reviewed. The total local-regional failure rate was 38% (49/130 patients), with 21 patients having local-regional failure alone and 28 patients having local-regional failure and distant metastases. The incidence of local failure rose with the more advanced stages of disease. Tumors staged B2, B3, C2, and C3 had local-regional failure rates in excess of 35%. This group of patients might benefit from adjuvant radiation therapy to the tumor bed and regional lymphatics. Local-regional failure rate was highest in the anastomosis or stump 33/130 (25%), followed by the stomach bed 27/130 (21%). The overall incidence of distant metastases was 52% (67/130 patients) and rose in the more advanced disease stages. Tumors staged B2, B3, C2, and C3 had rates of distant metastases greater than 50%. Sixty-one patients (77%) had failure in the abdomen (liver, peritoneal surface, adrenal, kidney, and spleen, but excluding tumor bed, anastomosis, or regional nodes). Patients with Stage B2, B3, C2, and C3 tumors had total abdominal failure rates greater than 40%. The highest failure rates in the liver were in Stages B3, and C3, in which the subsequent development of liver metastasis was 40% and 47%, respectively. Peritoneal seeding occurred in 30/130 (23%) of patients and was highest in Stages C2 and C3, with rates of 27% and 41%, respectively. C1 MASSACHUSETTS GEN HOSP,CTR CANC,DEPT RADIAT MED,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,CTR CANC,DEPT SURG,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,CTR CANC,DEPT PATHOL,BOSTON,MA 02114. NR 17 TC 164 Z9 172 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD DEC PY 1990 VL 19 IS 6 BP 1357 EP 1362 PG 6 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA EQ580 UT WOS:A1990EQ58000004 PM 2262358 ER PT J AU PFEFFER, MR TEICHER, BA HOLDEN, SA ALACHI, A HERMAN, TS AF PFEFFER, MR TEICHER, BA HOLDEN, SA ALACHI, A HERMAN, TS TI THE INTERACTION OF CISPLATIN PLUS ETOPOSIDE WITH RADIATION +/- HYPERTHERMIA SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE TRIMODALITY THERAPY; HYPERTHERMIA; ETOPOSIDE; CDDP ID CELL LUNG-CANCER; MURINE TUMOR; ANTITUMOR-ACTIVITY; FIBRO-SARCOMA; CYTO-TOXICITY; HOECHST 33342; THERAPY; VP-16; INVITRO; CHEMOTHERAPY AB The addition of concurrent etoposide and cisplatin to radiation +/- hyperthermia was evaluated in the murine FSaIIC fibrosarcoma tumor system. Tumor growth delay (TGD) demonstrated that when the drugs were tested with radiation (3 Gy daily X 5) plus (43-degrees X 30 min) local hyperthermia, cisplatin/hyperthermia/radiation (TGD approximately 25 days) was significantly more effective than etoposide/hyperthermia/radiation (TGD approximately 14 days). The addition of etoposide to cisplatin/hyperthermia/radiation, however, yielded a significantly longer growth delay (approximately 34 days). Tumor cell survival studies demonstrated that hyperthermia (43-degrees-C, 30 minutes) was dose modifying for etoposide cytotoxicty (dose modifying factor approximately 2.0 as determined by comparisons of the slopes of the curves). The addition of etoposide to cisplatin modified cisplatin killing only slightly at 37-degrees-C or 43-degrees-C. Considerable additional cell kill was observed over a range of radiation doses with cisplatin, hyperthermia, and etoposide added singly or in combination, especially at the lowest radiation dose tested (5 Gy), but essentially no dose modifications was observed. Evaluation of Hoechst 33342 dye-selected tumor subpopulations demonstrated that cisplatin, etoposide, radiation (10Gy), etoposide plus radiation, and cisplatin plus radiation killed significantly fewer dim (presumably hypoxic) cells than bright (presumably normally oxygenated) cells. Hyperthermia killed more dim than bright cells. The combination of hyperthermia with cisplatin and radiation, however, resulted in approximately 5-fold lesser kill in dim cells, and the addition of etoposide increased this differential to 6.4-fold. These results indicate that etoposide adds small but measurable antitumor effects when used with cisplatin alone or with cisplatin in combination with radiation +/- hyperthermia (especially at lower radiation fraction sizes). C1 JOINT CTR RADIAT THERAPY,44 BINNEY ST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. FU NCI NIH HHS [R01-CA47379, P01-CA38493, R01-CA36508] NR 41 TC 19 Z9 19 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD DEC PY 1990 VL 19 IS 6 BP 1439 EP 1447 PG 9 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA EQ580 UT WOS:A1990EQ58000016 PM 2262368 ER PT J AU LOEFFLER, JS ALEXANDER, E HOCHBERG, FH WEN, PY MORRIS, JH SCHOENE, WC SIDDON, RL MORSE, RH BLACK, PM AF LOEFFLER, JS ALEXANDER, E HOCHBERG, FH WEN, PY MORRIS, JH SCHOENE, WC SIDDON, RL MORSE, RH BLACK, PM TI CLINICAL-PATTERNS OF FAILURE FOLLOWING STEREOTAXIC INTERSTITIAL IRRADIATION FOR MALIGNANT GLIOMAS SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE STEREOTAXIC; BRACHYTHERAPY; RADIATION THERAPY; GLIOMA; RECURRENCE; IMPLANTATION ID GLIOBLASTOMA-MULTIFORME; BRAIN-TUMORS; RADIATION-THERAPY; BRACHYTHERAPY; SYSTEM; METASTASES; NEOPLASMS AB The vast majority of patients treated for malignant gliomas with surgery, conventional radiation therapy, and systemic chemotherapy recur within 2 cm of their original disease site as documented by CT scanning. We have analyzed the clinical patient of failure in patients treated with stereotactic interstitial irradiation (brachytherapy) for malignant gliomas in order to determine if this modality has altered the recurrence pattern in this disease. Between December 1985 and December 1989, 53 patients with malignant glioma were treated with stereotactic interstitial irradiation using temporary high activity iodine-125. Thirty-three patients were treated as part of a primary treatment protocol that included 5940 cGy external beam prior to implantation. Twenty patients were treated at time of recurrence. The median dose of radiation given at implantation was 5040 cGy for the primary lesions and 5450 cGy for the recurrent lesions. Twenty-two patients have suffered relapse as documented by clinical and radiographic studies. The predominant patterns of failure in these 22 patients were in the margins of the implant volume (8) and distant sites (10) within the CNS (distant ipsilateral or contralateral hemisphere, spinal axis) or extraneural. Thus, marginal and distant recurrences accounted for 82% of the relapses in our patients. We conclude stereotactic irradiation has changed the recurrence pattern in patients with malignant glioma with true local recurrence no longer being the predominant pattern of failure as is seen with conventional therapy. C1 HARVARD UNIV,SCH MED,DEPT SURG NEUROSURG,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED NEUROL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PATHOL NEUROPATHOL,BOSTON,MA 02115. HARVARD UNIV,MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114. HARVARD UNIV,BRIGHAM & WOMENS HOSP,JOINT CTR RADIAT THERAPY,BOSTON,MA 02115. HARVARD UNIV,BRIGHAM & WOMENS HOSP,NEUROSURG SERV,BOSTON,MA 02115. HARVARD UNIV,BRIGHAM & WOMENS HOSP,NEUROL SERV,BOSTON,MA 02115. HARVARD UNIV,BRIGHAM & WOMENS HOSP,NEUROPATHOL SERV,BOSTON,MA 02115. HARVARD UNIV,CHILDRENS HOSP,BOSTON,MA 02115. RP LOEFFLER, JS (reprint author), HARVARD UNIV,SCH MED,DEPT RADIAT THERAPY,50 BINNEY ST,BOSTON,MA 02115, USA. NR 30 TC 96 Z9 97 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD DEC PY 1990 VL 19 IS 6 BP 1455 EP 1462 PG 8 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA EQ580 UT WOS:A1990EQ58000018 PM 2262370 ER PT J AU CHOI, NC AF CHOI, NC TI ACCELERATED RADIATION-THERAPY IN SMALL-CELL LUNG-CANCER - RATIONALE AND LIMITATION IN ITS UTILITY SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Editorial Material ID COMBINATION CHEMOTHERAPY; CARCINOMA; FRACTIONATION; RADIOTHERAPY; ADRIAMYCIN; SCHEDULES RP CHOI, NC (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,CTR CANC,SCH MED,DEPT RADIAT MED,DEPT RADIAT THERAPY,BOSTON,MA 02114, USA. NR 22 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD DEC PY 1990 VL 19 IS 6 BP 1623 EP 1625 PG 3 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA EQ580 UT WOS:A1990EQ58000040 PM 2175740 ER PT J AU LIN, CP STERN, D PULIAFITO, CA AF LIN, CP STERN, D PULIAFITO, CA TI HIGH-SPEED PHOTOGRAPHY OF ER-YAG LASER ABLATION IN FLUID - IMPLICATION FOR LASER VITREOUS SURGERY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article DE ER-YAG; MIDINFRARED; LASER; ABLATION; VITRECTOMY ID CARBON-DIOXIDE LASER; MEMBRANES; TISSUE; RADIATION; NEODYMIUM AB The mechanism of Er:YAG laser-induced long-range damage in intraocular surgery was investigated using high-speed photography. A short pulse of 2.94-mu-m radiation delivered by an optical fiber into an aqueous medium causes rapid localized heating and vaporization and creates a bubble at the tip of the fiber. The size of the bubble depends on the pulse energy and is about 1 mm at 1 mJ. The shape of the bubble has multiple lobes, which can be attributed to the spiky output of the laser pulse. The expanding bubble can cause thermal and mechanical damage to tissues. In addition, laser spikes propagating through the bubble can strike and damage tissue on the distal side of the bubble. In both mechanisms the damage zone approximates the bubble size and can be greater than 1 mm, ie, 1000 times the steady-state absorption length of water at 2.94-mu-m. The authors discuss ways to reduce the damage zone by bubble confinement. RP LIN, CP (reprint author), HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,LASER RES LAB,243 CHARLES ST,BOSTON,MA 02114, USA. FU NEI NIH HHS [2-R44-EY07471-0]; NIGMS NIH HHS [GM-35459] NR 20 TC 54 Z9 55 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD DEC PY 1990 VL 31 IS 12 BP 2546 EP 2550 PG 5 WC Ophthalmology SC Ophthalmology GA EQ582 UT WOS:A1990EQ58200008 PM 2265992 ER PT J AU WODICKA, GR SHANNON, DC AF WODICKA, GR SHANNON, DC TI TRANSFER-FUNCTION OF SOUND-TRANSMISSION IN SUBGLOTTAL HUMAN RESPIRATORY SYSTEM AT LOW-FREQUENCIES SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ACOUSTIC TRANSMISSION; LUNG SOUNDS; THORACIC CAVITY ID NORMAL MEN; SPEED; LUNG AB The amplitude of sound transmission from the mouth to a site overlying the extrathoracic trachea and two sites on the posterior chest wall was measured in eight healthy adult male subjects at resting lung volume over the 100- to 600-Hz frequency range. The ratios of the estimated magnitude spectra of transmission of each of the chest wall sites to the tracheal site were determined, with the resulting spectra representing effective transfer functions of transmission in the subglottal system. For the group, the transfer functions exhibited a single peak, which occurred at 143 +/- 13 Hz (mean +/- SD) with a quality factor (Q) of 2.0 +/- 0.2 for the upper chest wall site and at 129 +/- 6 Hz with a Q of 2.2 +/- 0.4 for the lower site. The trend of decreasing spectral energy with increasing frequency was indicated by roll-offs of -10 +/- 4 and -17 +/- 5 dB/octave from 300 to 600 Hz at the two sites, respectively. The fundamental radial mode of a model thoracic cavity, which is a large rigid cyclinder filled with lossless lung tissue, provides a good estimate of the observed low-frequency resonance. This agreement suggests that thoracic cavity resonances may have particularly important effect on sound transmissions at frequencies below approximately 250 Hz, where the magnitude of parenchymal attenuation appears to be small. C1 PURDUE UNIV,HILLENBRAND BIOMED ENGN CTR,W LAFAYETTE,IN 47907. MASSACHUSETTS GEN HOSP,CHILDRENS SERV,PEDIAT PULM UNIT,BOSTON,MA 02114. RP WODICKA, GR (reprint author), PURDUE UNIV,SCH ELECT ENGN,W LAFAYETTE,IN 47907, USA. NR 12 TC 31 Z9 31 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 1990 VL 69 IS 6 BP 2126 EP 2130 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA EQ391 UT WOS:A1990EQ39100028 PM 2077010 ER PT J AU GOLDBERG, MB BOYKO, SA CALDERWOOD, SB AF GOLDBERG, MB BOYKO, SA CALDERWOOD, SB TI TRANSCRIPTIONAL REGULATION BY IRON OF A VIBRIO-CHOLERAE VIRULENCE GENE AND HOMOLOGY OF THE GENE TO THE ESCHERICHIA-COLI FUR SYSTEM SO JOURNAL OF BACTERIOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,BOSTON,MA 02114. FU NIAID NIH HHS [AI27329] NR 37 TC 59 Z9 61 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD DEC PY 1990 VL 172 IS 12 BP 6863 EP 6870 PG 8 WC Microbiology SC Microbiology GA EL034 UT WOS:A1990EL03400037 PM 2174861 ER PT J AU MULROY, RD HARRIS, WH AF MULROY, RD HARRIS, WH TI FAILURE OF ACETABULAR AUTOGENOUS GRAFTS IN TOTAL HIP-ARTHROPLASTY - INCREASING INCIDENCE - A FOLLOW-UP NOTE SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID CONGENITAL DISLOCATION; REPLACEMENT; RECONSTRUCTION; DYSPLASIA AB We reported previously on the application of an autogenous femoral-head graft to the acetabulum during total hip arthroplasty for compensation of marked osseous deficiency in patients who had arthritis secondary to severe congenital dysplasia or dislocation of the hip. An average of seven years postoperatively, the graft seemed to have been a successful adjunct to the arthroplasty. Five years later, to assess our long-term results, we reviewed the findings in the same forty-six hips (thirty-seven patients) that we had studied previously. An average of 11.8 years after the total replacement and use of the autogenous femoral-head graft, nine hips (20 per cent) needed a second operation because the acetabular fixation had failed. Two had had a resection arthroplasty and seven, a complex revision. In one additional hip, a resection arthroplasty was done for infection that had developed after operative reattachment of the greater trochanter. In twelve of the remaining thirty-six hips, there was definite radiographic evidence of acetabular loosening. Thus, the total incidence of lossening of the acetabular component was 46 per cent (twenty-one hips). The average time from the index operation to the first definite radiographic evidence that the fixation had failed was 6.4 years (range, 2.9 to 12.7 years). While we recognize that application of a bulk autogenous graft to the acetabulum is useful when the acetabular bone stock is extremely deficient, we no longer recommend the use of bulk corticocancellous autogenous grafts in other situations. C1 MASSACHUSETTS GEN HOSP,ORTHOPAED BIOMECH LAB,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 27 TC 170 Z9 177 U1 1 U2 2 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD DEC PY 1990 VL 72A IS 10 BP 1536 EP 1540 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA EP038 UT WOS:A1990EP03800017 PM 2254363 ER PT J AU NEER, RM AF NEER, RM TI EFFECT OF SEASON ON ACTIVITY AND BONE-MINERAL DENSITY SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Letter ID DUAL-PHOTON-ABSORPTIOMETRY; PRECISION; SPINE RP NEER, RM (reprint author), MASSACHUSETTS GEN HOSP,MALLINCKRODT GEN CLIN RES CTR,MINERAL METAB UNIT,BOSTON,MA 02114, USA. NR 5 TC 2 Z9 3 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD DEC PY 1990 VL 5 IS 12 BP 1271 EP 1271 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EP141 UT WOS:A1990EP14100012 PM 2075840 ER PT J AU DIAMOND, MS STAUNTON, DE DEFOUGEROLLES, AR STACKER, SA GARCIAAGUILAR, J HIBBS, ML SPRINGER, TA AF DIAMOND, MS STAUNTON, DE DEFOUGEROLLES, AR STACKER, SA GARCIAAGUILAR, J HIBBS, ML SPRINGER, TA TI ICAM-1 (CD54) - A COUNTER-RECEPTOR FOR MAC-1 (CD11B CD18) SO JOURNAL OF CELL BIOLOGY LA English DT Article ID INTERCELLULAR-ADHESION MOLECULE-1; LFA-1 MEMBRANE MOLECULE; CELL-SURFACE ANTIGENS; LEUKOCYTE ADHESION; ENDOTHELIAL-CELLS; NEUTROPHIL ADHERENCE; BETA-SUBUNIT; TRANSENDOTHELIAL MIGRATION; P150,95 GLYCOPROTEINS; MONOCLONAL-ANTIBODIES AB While the leukocyte integrin lymphocyte function-associated antigen (LFA)-1 has been demonstrated to bind intercellular adhesion molecule (ICAM)-1, results with the related Mac-1 molecule have been controversial. We have used multiple cell binding assays, purified Mac-1 and ICAM-1, and cell lines transfected with Mac-1 and ICAM-1, and cell lines transfected with Mac-1 and ICAM-1 cDNAs to examine the interaction of ICAM-1 with Mac-1. Stimulated human umbilical vein endothelial cells (HUVECs), which express a high surface density of ICAM-1, bind to immunoaffinity-purified Mac-1 adsorbed to artificial substrates in a manner that is inhibited by mAbs to Mac-1 and ICAM-1. Transfected murine L cells or monkey COS cells expressing human ICAM-1 bind to purified Mac-1 in a specific and dose-dependent manner; the attachment to Mac-1 is more temperature sensitive, lower in avidity, and blocked by a different series of ICAM-1 mAbs when compared to LFA-1. In a reciprocal assay, COS cells cotransfected with the alpha- and beta-chain cDNAs of Mac-1 or LFA-1 attach to immunoaffinity-purified ICAM-1 substrates; this adhesion is blocked by mAbs to ICAM-1 and Mac-1 or LFA-1. Two color fluorescence cell conjugate experiments show that neutrophils stimulated with fMLP bind to HUVEC stimulated with lipopolysaccharide for 24 h in an ICAM-1-, Mac-1-, and LFA-1-dependent fashion. Because cellular and purified Mac-1 interact with cellular and purified ICAM-1, we conclude that ICAM-1 is a counter receptor for Mac-1 and that this receptor pair is responsible, in part, for the adhesion between stimulated neutrophils and stimulated endothelial cells. C1 HARVARD UNIV,SCH MED,DEPT PATHOL,COMM IMMUNOL,BOSTON,MA 02115. CTR BLOOD RES,BOSTON,MA 02115. RP DIAMOND, MS (reprint author), HARVARD UNIV,SCH MED,DEPT PATHOL,COMM CELL & DEV BIOL,BOSTON,MA 02115, USA. RI Hibbs, Margaret/D-7013-2011 FU NCI NIH HHS [CA31799]; NIGMS NIH HHS [T32 GM007753, T32GM07753-11] NR 65 TC 836 Z9 838 U1 3 U2 13 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9525 J9 J CELL BIOL JI J. Cell Biol. PD DEC PY 1990 VL 111 IS 6 BP 3129 EP 3139 DI 10.1083/jcb.111.6.3129 PN 2 PG 11 WC Cell Biology SC Cell Biology GA EN922 UT WOS:A1990EN92200028 PM 1980124 ER PT J AU RIOS, M WILLIAMS, DA AF RIOS, M WILLIAMS, DA TI SYSTEMATIC ANALYSIS OF THE ABILITY OF STROMAL CELL-LINES DERIVED FROM DIFFERENT MURINE ADULT TISSUES TO SUPPORT MAINTENANCE OF HEMATOPOIETIC STEM-CELLS INVITRO SO JOURNAL OF CELLULAR PHYSIOLOGY LA English DT Article ID BONE-MARROW; NUCLEOTIDE-SEQUENCE; SIMIAN VIRUS-40; MEDIATED HEMATOPOIESIS; RECOMBINANT RETROVIRUS; ANEMIC MICE; GM-CSF; MICROENVIRONMENT; PROLIFERATION; GROWTH AB Hematopoietic stem cells interact with a complex microenvironment both in vivo and in vitro. In association with microenvironment, murine stem cells are maintained in vitro for several months. Fibroblast-like stromal cells appear to be important components of the microenvironment, since several laboratories have demonstrated that cloned stromal cell lines support hematopoiesis in vitro. The importance of the tissue of origin of such cell lines remains unknown, since systematic generation of stromal cell lines from adult tissues has never been accomplished. In addition, the capacity of stromal cell lines to support reconstituting stem cell has not been examined. We have previously described an efficient and rapid method for the immortalization of primary bone marrow stromal cell lines (William et al., Mol. Cell. Biol. 8:3864-3871, 1988) which can be used to systematically derive cell lines from multiple tissues of the adult mouse. Here we report the immortalization of primary murine lung, kidney, skin, and bone marrow stromal cells using a recombinant retrovirus vector (U19-5) containing the simian virus large T antigen (SV40 LT) and the neophosphotransferase gene. The interaction of these stromal cells with factor-dependent cells Patterson-Mix (FDCP-Mix), colony forming units-spleen (CFU-S), and reconstituting hematopoietic stem cells was studied in order to analyze the ability of such lines to support multipotent stem cells in vitro. These studies revealed that stromal cell lines from these diverse tissues were morphologically and phenotypically similar and that they quantitatively bound CFU-S and FDCP-Mix cells equally well. However, only those cell lines derived from bone marrow-supported maintenance of day 12 CFU-S in vitro. One lung-derived stromal cell line, ULU-3, supported the survival of day 8 CFU-S, but not the more primitive CFU-S12. A bone marrow-derived stromal cell line, U2, supported the survival of long-term reconstituting stem cells for up to 3 weeks in vitro as assayed by reconstitution 1 year post-transplant. These studies suggest that adherence of HSC to stromal cells is necessary but not sufficient for maintenance of these stem cell populations and that bone marrow provides specific signals relating to hematopoietic stem cell survival and proliferation. C1 HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02115. HARVARD UNIV,CHILDRENS HOSP,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. FU NCI NIH HHS [CA 39542-05]; NHLBI NIH HHS [5 P01-NIH HL32262, 5K08 HL01554-02] NR 44 TC 46 Z9 47 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9541 J9 J CELL PHYSIOL JI J. Cell. Physiol. PD DEC PY 1990 VL 145 IS 3 BP 434 EP 443 DI 10.1002/jcp.1041450307 PG 10 WC Cell Biology; Physiology SC Cell Biology; Physiology GA EP622 UT WOS:A1990EP62200006 PM 1703166 ER PT J AU BROWN, FM SMITH, AM LONGWAY, S RABINOWE, SL AF BROWN, FM SMITH, AM LONGWAY, S RABINOWE, SL TI ADRENAL-MEDULLITIS IN TYPE-I DIABETES SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article C1 HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR, IMMUNOL SECT, BOSTON, MA 02215 USA. HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED, DIV DIABET & METAB, BOSTON, MA 02215 USA. HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DEPT PATHOL, BOSTON, MA 02215 USA. FU PHS HHS [888] NR 30 TC 15 Z9 15 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD DEC PY 1990 VL 71 IS 6 BP 1491 EP 1495 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL033 UT WOS:A1990EL03300016 PM 2229306 ER PT J AU KLIBANSKI, A AF KLIBANSKI, A TI FURTHER EVIDENCE FOR A SOMATIC MUTATION THEORY IN THE PATHOGENESIS OF HUMAN PITUITARY-TUMORS SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Editorial Material RP KLIBANSKI, A (reprint author), MASSACHUSETTS GEN HOSP, NEUROENDOCRINE UNIT, BOSTON, MA 02114 USA. NR 7 TC 24 Z9 24 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD DEC PY 1990 VL 71 IS 6 BP A1415 EP + PG 0 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL033 UT WOS:A1990EL03300003 ER PT J AU DOYLE, LA BORGES, M HUSSAIN, A ELIAS, A TOMIYASU, T AF DOYLE, LA BORGES, M HUSSAIN, A ELIAS, A TOMIYASU, T TI AN ADHERENT SUBLINE OF A UNIQUE SMALL-CELL LUNG-CANCER CELL-LINE DOWN-REGULATES ANTIGENS OF THE NEURAL CELL-ADHESION MOLECULE SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article C1 UNIV MARYLAND,SCH MED,CTR CANC,DEPT MED,BALTIMORE,MD 21201. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. RP DOYLE, LA (reprint author), UNIV MARYLAND,SCH MED,CTR CANC,22 S GREENE ST,BALTIMORE,MD 21201, USA. FU NCI NIH HHS [K08 CA0167] NR 43 TC 30 Z9 30 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD DEC PY 1990 VL 86 IS 6 BP 1848 EP 1854 DI 10.1172/JCI114915 PG 7 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EL763 UT WOS:A1990EL76300011 PM 1701450 ER PT J AU LEE, JW MELCHER, GA RINALDI, MG PIZZO, PA WALSH, TJ AF LEE, JW MELCHER, GA RINALDI, MG PIZZO, PA WALSH, TJ TI PATTERNS OF MORPHOLOGICAL VARIATION AMONG ISOLATES OF TRICHOSPORON-BEIGELII SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note C1 NCI,PEDIAT BRANCH,INFECT DIS SECT,BETHESDA,MD 20892. UNIV TEXAS,DEPT PATHOL,SAN ANTONIO,TX 78285. WILFORD HALL USAF MED CTR,INFECT DIS SECT,LACKLAND AFB,TX 78236. AUDIE L MURPHY MEM VET ADM MED CTR,LAB SERV,SAN ANTONIO,TX 78284. NR 12 TC 36 Z9 37 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 1990 VL 28 IS 12 BP 2823 EP 2827 PG 5 WC Microbiology SC Microbiology GA EJ459 UT WOS:A1990EJ45900049 PM 2280018 ER PT J AU KAPLAN, WD JOCHELSON, MS HERMAN, TS NADLER, LM STOMPER, PC TAKVORIAN, T ANDERSEN, JW CANELLOS, GP AF KAPLAN, WD JOCHELSON, MS HERMAN, TS NADLER, LM STOMPER, PC TAKVORIAN, T ANDERSEN, JW CANELLOS, GP TI GA-67 IMAGING - A PREDICTOR OF RESIDUAL TUMOR VIABILITY AND CLINICAL OUTCOME IN PATIENTS WITH DIFFUSE LARGE-CELL LYMPHOMA SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article C1 JOINT CTR RADIAT THERAPY,BOSTON,MA. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT MED,DIV NUCL MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT BIOSTAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP KAPLAN, WD (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT RADIOL,DIV NUCL MED,44 BINNEY ST,BOSTON,MA 02115, USA. NR 20 TC 134 Z9 134 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD DEC PY 1990 VL 8 IS 12 BP 1966 EP 1970 PG 5 WC Oncology SC Oncology GA EK923 UT WOS:A1990EK92300006 PM 2230889 ER PT J AU EPSTEIN, RJ AF EPSTEIN, RJ TI DRUG-INDUCED DNA DAMAGE AND TUMOR CHEMOSENSITIVITY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Review C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RP EPSTEIN, RJ (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT CELL & MOLEC BIOL,M830,44 BINNEY ST,BOSTON,MA 02115, USA. NR 354 TC 68 Z9 69 U1 0 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD DEC PY 1990 VL 8 IS 12 BP 2062 EP 2084 PG 23 WC Oncology SC Oncology GA EK923 UT WOS:A1990EK92300019 PM 2230898 ER PT J AU GELMAN, R GELBER, R HENDERSON, IC COLEMAN, CN HARRIS, JR AF GELMAN, R GELBER, R HENDERSON, IC COLEMAN, CN HARRIS, JR TI ANALYZING LOCAL AND DISTANT RECURRENCE - REPLY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Letter RP GELMAN, R (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD DEC PY 1990 VL 8 IS 12 BP 2087 EP 2088 PG 2 WC Oncology SC Oncology GA EK923 UT WOS:A1990EK92300022 ER PT J AU ROSENBAUM, JF AF ROSENBAUM, JF TI PANIC DISORDER - DIATHESIS AND TREATMENT ISSUES - INTRODUCTION SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article; Proceedings Paper CT 143RD ANNUAL MEETING OF THE AMERICAN PSYCHIATRIC ASSOC CY MAY 12-17, 1990 CL NEW YORK, NY SP AMER PSYCHIAT ASSOC C1 HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. RP ROSENBAUM, JF (reprint author), MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,15 PARKMAN ST,BOSTON,MA 02114, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 240008, MEMPHIS, TN 38124 SN 0160-6689 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD DEC PY 1990 VL 51 SU A BP 3 EP 4 PG 2 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA ER838 UT WOS:A1990ER83800001 ER PT J AU POLLACK, MH OTTO, MW ROSENBAUM, JF SACHS, GS ONEIL, C ASHER, R MELTZERBRODY, S AF POLLACK, MH OTTO, MW ROSENBAUM, JF SACHS, GS ONEIL, C ASHER, R MELTZERBRODY, S TI LONGITUDINAL COURSE OF PANIC DISORDER - FINDINGS FROM THE MASSACHUSETTS GENERAL-HOSPITAL NATURALISTIC STUDY SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article; Proceedings Paper CT 143RD ANNUAL MEETING OF THE AMERICAN PSYCHIATRIC ASSOC CY MAY 12-17, 1990 CL NEW YORK, NY SP AMER PSYCHIAT ASSOC ID III PERSONALITY-DISORDER; FOLLOW-UP; ANXIETY SENSITIVITY; AGORAPHOBIA; CHILDREN; ATTACKS; PARENTS; FAMILY AB Clinical experience and controlled studies confirm the efficacy of pharmacologic and cognitive-behavioral interventions for the acute treatment of panic disorder and agoraphobia. However, while some patients experience long periods of true remission, panic disorder remains chronic for many, with intermittent periods of acute exacerbation and continued residual distress. Findings from the Massachusetts General Hospital Naturalistic Study of the Longitudinal Course of Panic Disorder suggest that (1) a number of factors contribute to the severity and persistence of panic disorder, including phobic subtype, comorbid anxiety disorders, depression, personality disorders, and anxiety sensitivity; (2) chronicity is common; (3) for some, an anxiety diathesis is manifested early in childhood and sets the tone for later chronicity and comorbidity; (4) maladaptive personality characteristics may be manifestations of an underlying anxiety disorder; (5) patients with continued symptomatology despite improvement may benefit from the flexible integration of pharmacologic and cognitive-behavioral treatment approaches; and (6) long-term treatment is indicated for many patients. C1 MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,ANXIETY CLIN RES UNIT,BOSTON,MA 02114. RP POLLACK, MH (reprint author), CLIN PSYCHOPHARMACOL UNIT,ACC 815,15 PARKMAN ST,BOSTON,MA 02114, USA. NR 30 TC 88 Z9 89 U1 2 U2 2 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 240008, MEMPHIS, TN 38124 SN 0160-6689 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD DEC PY 1990 VL 51 SU A BP 12 EP 16 PG 5 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA ER838 UT WOS:A1990ER83800003 PM 2258371 ER PT J AU ROSENBAUM, JF AF ROSENBAUM, JF TI SUMMARY SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. RP ROSENBAUM, JF (reprint author), MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,15 PARKMAN ST,BOSTON,MA 02114, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 240008, MEMPHIS, TN 38124 SN 0160-6689 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD DEC PY 1990 VL 51 SU A BP 46 EP 47 PG 2 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA ER838 UT WOS:A1990ER83800008 ER PT J AU TAKAHASHI, T MISSON, JP CAVINESS, VS AF TAKAHASHI, T MISSON, JP CAVINESS, VS TI GLIAL PROCESS ELONGATION AND BRANCHING IN THE DEVELOPING MURINE NEOCORTEX - A QUALITATIVE AND QUANTITATIVE IMMUNOHISTOCHEMICAL ANALYSIS SO JOURNAL OF COMPARATIVE NEUROLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. STATE UNIV LIEGE,DEPT DEV NEUROBIOL,B-4000 LIEGE,BELGIUM. RP TAKAHASHI, T (reprint author), MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114, USA. FU NINDS NIH HHS [NS 12005] NR 47 TC 80 Z9 80 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9967 J9 J COMP NEUROL JI J. Comp. Neurol. PD DEC 1 PY 1990 VL 302 IS 1 BP 15 EP 28 DI 10.1002/cne.903020103 PG 14 WC Neurosciences; Zoology SC Neurosciences & Neurology; Zoology GA EL761 UT WOS:A1990EL76100002 PM 2086612 ER PT J AU HURFORD, WE ZAPOL, WM LYNCH, KE FLAMM, S LOWENSTEIN, E STRAUSS, HW AF HURFORD, WE ZAPOL, WM LYNCH, KE FLAMM, S LOWENSTEIN, E STRAUSS, HW TI THE INFLUENCE OF POSITIVE END-EXPIRATORY PRESSURE ON PULMONARY BLOOD-VOLUME CHANGES IN ADULT RESPIRATORY-DISTRESS SYNDROME SO JOURNAL OF CRITICAL CARE LA English DT Article RP HURFORD, WE (reprint author), MASSACHUSETTS GEN HOSP,DEPT ANAESTHESIA,BOSTON,MA 02114, USA. RI Hurford, William/G-6386-2013 OI Hurford, William/0000-0003-1201-0313 NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0883-9441 J9 J CRIT CARE JI J. Crit. Care PD DEC PY 1990 VL 5 IS 4 BP 228 EP 237 DI 10.1016/0883-9441(90)90044-A PG 10 WC Critical Care Medicine SC General & Internal Medicine GA EM312 UT WOS:A1990EM31200003 ER PT J AU EZEKOWITZ, RAB SASTRY, K BAILLY, P WARNER, A AF EZEKOWITZ, RAB SASTRY, K BAILLY, P WARNER, A TI MOLECULAR CHARACTERIZATION OF THE HUMAN MACROPHAGE MANNOSE RECEPTOR - DEMONSTRATION OF MULTIPLE CARBOHYDRATE RECOGNITION-LIKE DOMAINS AND PHAGOCYTOSIS OF YEASTS IN COS-1 CELLS SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article C1 HARVARD UNIV,SCH PUBL HLTH,DEPT RESP BIOL,BOSTON,MA 02115. RP EZEKOWITZ, RAB (reprint author), HARVARD UNIV,CHILDRENS HOSP,DANA FARBER CANC INST,DEPT PEDIAT,DIV HEMATOL ONCOL,ENDERS BLDG,BOSTON,MA 02115, USA. FU NHLBI NIH HHS [P01-HL43510-01]; PHS HHS [R01-23786] NR 47 TC 349 Z9 359 U1 0 U2 10 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1990 VL 172 IS 6 BP 1785 EP 1794 DI 10.1084/jem.172.6.1785 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EL849 UT WOS:A1990EL84900029 PM 2258707 ER PT J AU SCOTT, S PANDOLFI, F KURNICK, JT AF SCOTT, S PANDOLFI, F KURNICK, JT TI FIBROBLASTS MEDIATE T-CELL SURVIVAL - A PROPOSED MECHANISM FOR RETENTION OF PRIMED T-CELLS SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Note C1 MASSACHUSETTS GEN HOSP E,PATHOL RES LAB,7TH FLOOR,149 13TH ST,BOSTON,MA 02129. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PATHOL,BOSTON,MA 02114. FU NCI NIH HHS [CA-44324]; NIAMS NIH HHS [AR-39993] NR 13 TC 82 Z9 82 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1990 VL 172 IS 6 BP 1873 EP 1876 DI 10.1084/jem.172.6.1873 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EL849 UT WOS:A1990EL84900040 PM 2258711 ER PT J AU CANTIELLO, HF CRABOS, M PATENAUDE, CR AUSIELLO, DA AF CANTIELLO, HF CRABOS, M PATENAUDE, CR AUSIELLO, DA TI REGULATION OF CATION-TRANSPORT BY A VOLTAGE-DEPENDENT NA+ PUMP IN LLC-PK1 EPITHELIAL-CELLS SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,DEPT MED,RENAL UNIT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1295 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD DEC PY 1990 VL 96 IS 6 BP A73 EP A73 PG 1 WC Physiology SC Physiology GA EM922 UT WOS:A1990EM92200123 ER PT J AU HAUPERT, GT KACHORIS, C AF HAUPERT, GT KACHORIS, C TI PHYSIOLOGICAL REGULATION OF THE NA+,K+-ATPASE - VASOCONSTRICTIVE EFFECTS OF THE ENDOGENOUS NA+,K+-ATPASE INHIBITOR FROM HYPOTHALAMUS SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Meeting Abstract C1 HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, RENAL UNIT, BOSTON, MA 02114 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA SN 0022-1295 EI 1540-7748 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD DEC PY 1990 VL 96 IS 6 BP A84 EP A84 PG 1 WC Physiology SC Physiology GA EM922 UT WOS:A1990EM92200148 ER PT J AU HAUPERT, GT HALLAQ, HA AF HAUPERT, GT HALLAQ, HA TI PHYSIOLOGICAL REGULATION OF THE NA+,K+-ATPASE - POSITIVE INOTROPIC EFFECTS OF THE ENDOGENOUS NA+,K+-ATPASE INHIBITOR FROM HYPOTHALAMUS SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Meeting Abstract C1 HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, RENAL UNIT, BOSTON, MA 02114 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA SN 0022-1295 EI 1540-7748 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD DEC PY 1990 VL 96 IS 6 BP A84 EP A84 PG 1 WC Physiology SC Physiology GA EM922 UT WOS:A1990EM92200147 ER PT J AU LUCCHESI, PA SWEADNER, KJ AF LUCCHESI, PA SWEADNER, KJ TI DEVELOPMENTAL-CHANGES IN NA,K-ATPASE ISOZYME EXPRESSION IN RAT CARDIAC TISSUE SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT MOLEC & CELLULAR PHYSIOL,BOSTON,MA 02115. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1295 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD DEC PY 1990 VL 96 IS 6 BP A64 EP A64 PG 1 WC Physiology SC Physiology GA EM922 UT WOS:A1990EM92200104 ER PT J AU SWEADNER, KJ MCGRAIL, KM PHILLIPS, JM AF SWEADNER, KJ MCGRAIL, KM PHILLIPS, JM TI DISTRIBUTION OF NA,K-ATPASE ALPHA-ISOFORMS IN THE NERVOUS-SYSTEM - HISTOCHEMICAL EVIDENCE FOR ACTIVITY DIFFERENCES SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT CELLULAR & MOLEC PHYSIOL,BOSTON,MA 02115. NR 0 TC 3 Z9 3 U1 2 U2 2 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1295 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD DEC PY 1990 VL 96 IS 6 BP A64 EP A64 PG 1 WC Physiology SC Physiology GA EM922 UT WOS:A1990EM92200103 ER PT J AU SMITH, JG MAGEE, DM WILLIAMS, DM GRAYBILL, JR AF SMITH, JG MAGEE, DM WILLIAMS, DM GRAYBILL, JR TI TUMOR-NECROSIS-FACTOR-ALPHA PLAYS A ROLE IN HOST DEFENSE AGAINST HISTOPLASMA-CAPSULATUM SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article C1 AUDIE L MURPHY MEM VET ADM MED CTR,DEPT INFECT DIS 111F,INFECT DIS SECT,7400 MERTON MINTER BLVD,SAN ANTONIO,TX 78284. NR 32 TC 94 Z9 94 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1990 VL 162 IS 6 BP 1349 EP 1353 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA EK574 UT WOS:A1990EK57400019 PM 2230264 ER PT J AU MEYER, RD MOUDGIL, T DETELS, R PHAIR, JP HIRSCH, MS HO, DD AF MEYER, RD MOUDGIL, T DETELS, R PHAIR, JP HIRSCH, MS HO, DD TI SEROPREVALENCE OF HUMAN T-CELL LEUKEMIA VIRUSES IN SELECTED POPULATIONS OF HOMOSEXUAL MEN SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note C1 NORTHWESTERN UNIV,SCH MED,INFECT DIS SECT,CHICAGO,IL 60611. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,INFECT DIS UNIT,BOSTON,MA 02114. UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH PUBL HLTH,LOS ANGELES,CA 90048. RP MEYER, RD (reprint author), UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,ROOM B226,LOS ANGELES,CA 90048, USA. FU NIAID NIH HHS [AI-25915, AI-32535, AI-72631] NR 17 TC 5 Z9 5 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1990 VL 162 IS 6 BP 1370 EP 1372 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA EK574 UT WOS:A1990EK57400023 PM 2230268 ER PT J AU MAYTIN, EV WIMBERLY, JM ANDERSON, RR AF MAYTIN, EV WIMBERLY, JM ANDERSON, RR TI THERMOTOLERANCE AND THE HEAT-SHOCK RESPONSE IN NORMAL HUMAN KERATINOCYTES IN CULTURE SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Article ID PSORIATIC PLAQUES; PROTEIN-SYNTHESIS; RAT FIBROBLASTS; MESSENGER-RNA; STRESS; HSP70; HYPERTHERMIA; ANTIBODIES; EXPRESSION; KINETICS AB Protective responses of normal human epidermal keratinocytes in culture, after exposure to elevated temperatures ("heat shock"), were examined. Cell viability, measured 24-48 h after a 20-min heat challenge at temperatures between 37-degrees-C and 54-degrees-C, declined sharply within a narrow 2-degrees-C-3-degrees-C range. However, conditioning with a mild thermal pretreatment (40-degrees-C or 42-degrees-C for 1 h) protected the keratinocytes against a subsequent heat challenge. This induced thermotolerance was apparent when cells were challenged at 1, 3, and 6 h after the thermal pre-treatment, but disappeared by 24 h. Heating conditions that induce thermotolerance also stimulated the synthesis of heat-shock proteins (hsp) in these cells. Inductions of prominent S-35-methionine labeled bands at 70, 78, and 90 kDa were observed. However, the increases in synthesis of these heat-shock proteins did not correlate well with thermotolerance, because large increases were also observed at certain elevated temperatures that did not produce improved survival. Keratins observed in these cells (50 and 58 kDa classes) were not induced by heat shock. The development of thermotolerance, and the induction of hsp, were both completely blocked by 3'-deoxyadenosine (cordycepin), an inhibitor of newly synthesized messenger RNA, but not by adenosine, the normal analog. While heat-inducible mRNA apparently mediate some function important for the development of thermotolerance, the nature of that role remains speculative. Overall, our findings establish the existence of a functional thermal protective mechanism in human keratinocytes that appears to require the synthesis of new mRNA. RP MAYTIN, EV (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT DERMATOL,WELLMAN LABS PHOTOMED,BOSTON,MA 02114, USA. FU NIAMS NIH HHS [5T32AR07098-15] NR 40 TC 44 Z9 45 U1 0 U2 2 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD DEC PY 1990 VL 95 IS 6 BP 635 EP 642 DI 10.1111/1523-1747.ep12514303 PG 8 WC Dermatology SC Dermatology GA EP025 UT WOS:A1990EP02500004 PM 2250106 ER PT J AU GRANSTEIN, RD FLOTTE, TJ AMENTO, EP AF GRANSTEIN, RD FLOTTE, TJ AMENTO, EP TI INTERFERONS AND COLLAGEN PRODUCTION SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL DERMATOLOGY SYMP : INTERFERON AND RELATED CYTOKINES CY OCT 11-14, 1989 CL BERLIN, FED REP GER SP GERMAN DERMATOL SOC, SOC IMMUNOL, FREE UNIV BERLIN ID PROCOLLAGEN MESSENGER-RNA; RECOMBINANT GAMMA-INTERFERON; RHEUMATOID SYNOVIAL-CELLS; FIBROBLAST COLLAGEN; IMMUNE INTERFERON; SCLERODERMA FIBROBLASTS; DOUBLE-BLIND; INHIBITION; INTERLEUKIN-1; ARTHRITIS AB The immunoregulatory, antiviral, and antiproliferative agents known as the interferons have profound effects on collagen synthesis. Interferons-alpha, beta and gamma suppress collagen synthesis by dermal fibroblasts. In addition, interferon-gamma (IFN-gamma) inhibits the constitutively increased collagen synthesis characteristic of fibroblasts derived from lesions of patients with scleroderma. IFN-gamma also inhibits collagen synthesis by myofibroblasts and synovial fibroblast-like cells. Inhibition of collagen synthesis by IFN-gamma is associated with a coordinate inhibition of transcription for types I and III collagen. In addition, IFN-gamma suppresses levels of procollagen mRNA and type II collagen synthesis in human articular chondrocytes. In vivo studies in mice have demonstrated that IFN-gamma inhibits the collagen synthesis associated with the fibrotic response to an implanted foreign body, bleomycin-induced pulmonary fibrosis, and the healing response to cutaneous thermal burns. In the latter case, while collagen content of the wound scar was decreased, hyaluronic acid was increased in mice receiving IFN-gamma compared to controls. This is in accord with in vitro studies showing that, while interferons-alpha and beta decrease production of glycosaminoglycans, IFN-gamma increases production of glycosaminoglycans. Of interest, acute inflammation at sites of thermal injury, or when elicited by proinflammatory agents in separate experiments, also was suppressed in mice treated with IFN-gamma. The means by which IFN-gamma inhibits collagen synthesis involves transcriptional regulation. There is a single report that interferon-alpha can decrease the size of a keloid of recent onset in a human patient. Because the interferons can inhibit collagen synthesis in vivo, further studies may be warranted to evaluate the usefulness of these agents in the treatment of disease states characterized by abnormal fibrotic responses as well as their potential for altering the healing response associated with particular therapeutic interventions. C1 GENENTECH INC,MOLEC IMMUNOL,S SAN FRANCISCO,CA. RP GRANSTEIN, RD (reprint author), MASSACHUSETTS GEN HOSP,DEPT DERMATOL,WELLMAN LABS PHOTOMED,WELLMAN 2,BOSTON,MA 02114, USA. FU NIADDK NIH HHS [AM 1425-05] NR 43 TC 55 Z9 56 U1 1 U2 3 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD DEC PY 1990 VL 95 IS 6 SU S BP S75 EP S80 DI 10.1111/1523-1747.ep12874789 PG 6 WC Dermatology SC Dermatology GA EQ167 UT WOS:A1990EQ16700004 PM 2258640 ER PT J AU NEUMEYER, JL GAO, YG KULA, NS BALDESSARINI, RJ AF NEUMEYER, JL GAO, YG KULA, NS BALDESSARINI, RJ TI SYNTHESIS AND DOPAMINE RECEPTOR AFFINITY OF (R)-(-)-2-FLUORO-N-NORMAL-PROPYLNORAPOMORPHINE - A HIGHLY POTENT AND SELECTIVE DOPAMINE-D2 AGONIST SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Letter C1 NORTHEASTERN UNIV,COLL PHARM & ALLIED HLTH PROFESS,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,MCLEAN DIV,MAILMAN RES CTR,BELMONT,MA 02178. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BELMONT,MA 02178. HARVARD UNIV,NEUROSCI PROGRAM,BELMONT,MA 02178. RP NEUMEYER, JL (reprint author), RES BIOCHEM INC,1 STRATHMORE RD,NATICK,MA 01760, USA. FU NIMH NIH HHS [MH-47370, MH-34006] NR 15 TC 25 Z9 25 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD DEC PY 1990 VL 33 IS 12 BP 3122 EP 3124 DI 10.1021/jm00174a002 PG 3 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA EK459 UT WOS:A1990EK45900002 PM 2147956 ER PT J AU VATNER, DE AF VATNER, DE TI CHARACTERIZATION OF SUBFRACTIONS FROM PURIFIED SARCOLEMMA OF CANINE LEFT-VENTRICLE SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY LA English DT Article C1 HARVARD UNIV, MASSACHUSETTS GEN HOSP,SCH MED,DEPT PEDIAT, CHILDRENS SERV, BOSTON, MA 02114 USA. RP NEW ENGLAND REG PRIMATE RES CTR, 1 PINE HILL DR, SOUTHBOROUGH, MA 01772 USA. FU NHLBI NIH HHS [HL 45332, HL 38070, HL 37404] NR 27 TC 6 Z9 6 U1 0 U2 0 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-2828 EI 1095-8584 J9 J MOL CELL CARDIOL JI J. Mol. Cell. Cardiol. PD DEC PY 1990 VL 22 IS 12 BP 1349 EP 1357 DI 10.1016/0022-2828(90)90980-G PG 9 WC Cardiac & Cardiovascular Systems; Cell Biology SC Cardiovascular System & Cardiology; Cell Biology GA EL793 UT WOS:A1990EL79300002 PM 1965209 ER PT J AU LOUIS, DN SWEARINGEN, B LINGGOOD, RM DICKERSIN, GR KRETSCHMAR, C BHAN, AK HEDLEYWHYTE, ET AF LOUIS, DN SWEARINGEN, B LINGGOOD, RM DICKERSIN, GR KRETSCHMAR, C BHAN, AK HEDLEYWHYTE, ET TI CENTRAL-NERVOUS-SYSTEM NEUROCYTOMA AND NEUROBLASTOMA IN ADULTS-REPORT OF 8 CASES SO JOURNAL OF NEURO-ONCOLOGY LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT RADIAT MED,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT PEDIAT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 27 TC 92 Z9 92 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-594X J9 J NEURO-ONCOL JI J. Neuro-Oncol. PD DEC PY 1990 VL 9 IS 3 BP 231 EP 238 DI 10.1007/BF02341154 PG 8 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA EL510 UT WOS:A1990EL51000006 PM 2086738 ER PT J AU SAKAS, DE CHARNVISES, K BORGES, LF ZERVAS, NT AF SAKAS, DE CHARNVISES, K BORGES, LF ZERVAS, NT TI BIOLOGICALLY INERT SYNTHETIC DURAL SUBSTITUTES - APPRAISAL OF A MEDICAL-GRADE ALIPHATIC POLYURETHANE AND A POLYSILOXANE-CARBONATE BLOCK COPOLYMER SO JOURNAL OF NEUROSURGERY LA English DT Article C1 MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA 02115. NR 54 TC 27 Z9 33 U1 0 U2 2 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD DEC PY 1990 VL 73 IS 6 BP 936 EP 941 DI 10.3171/jns.1990.73.6.0936 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA EK583 UT WOS:A1990EK58300015 PM 2230977 ER PT J AU SCOTT, JA AF SCOTT, JA TI SOMBREROS-CIENTIFICOS SO JOURNAL OF NUCLEAR MEDICINE LA English DT Editorial Material RP SCOTT, JA (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD DEC PY 1990 VL 31 IS 12 BP 1986 EP 1988 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN644 UT WOS:A1990EN64400022 PM 2266397 ER PT J AU CALLAHAN, RJ RABITO, CA AF CALLAHAN, RJ RABITO, CA TI RADIOLABELING OF ERYTHROCYTES WITH TC-99M - ROLE OF BAND-3 PROTEIN IN THE TRANSPORT OF PERTECHNETATE ACROSS THE CELL-MEMBRANE SO JOURNAL OF NUCLEAR MEDICINE LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT CLIN,DIV NUCL MED,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 33 TC 43 Z9 48 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD DEC PY 1990 VL 31 IS 12 BP 2004 EP 2010 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN644 UT WOS:A1990EN64400025 PM 2176234 ER PT J AU ABRAMS, MJ JUWEID, M TENKATE, CI SCHWARTZ, DA HAUSER, MM GAUL, FE FUCCELLO, AJ RUBIN, RH STRAUSS, HW FISCHMAN, AJ AF ABRAMS, MJ JUWEID, M TENKATE, CI SCHWARTZ, DA HAUSER, MM GAUL, FE FUCCELLO, AJ RUBIN, RH STRAUSS, HW FISCHMAN, AJ TI TECHNETIUM-99M-HUMAN POLYCLONAL IGG RADIOLABELED VIA THE HYDRAZINO NICOTINAMIDE DERIVATIVE FOR IMAGING FOCAL SITES OF INFECTION IN RATS SO JOURNAL OF NUCLEAR MEDICINE LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,DIV NUCL MED,32 FRUIT ST,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,MED SERV,INFECT DIS UNIT,BOSTON,MA 02114. ROBERT WOOD JOHNSON PHARMACEUT RES INST,RARITAN,NJ. JOHNSON MATTHEY PHARMACEUT RES,W CHESTER,PA. HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. NR 14 TC 358 Z9 368 U1 0 U2 17 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD DEC PY 1990 VL 31 IS 12 BP 2022 EP 2028 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN644 UT WOS:A1990EN64400028 PM 2266401 ER PT J AU CALLAHAN, RJ AF CALLAHAN, RJ TI IN PRAISE OF THE MIGHTY RED-CELL SO JOURNAL OF NUCLEAR MEDICINE LA English DT Editorial Material C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,BOSTON,MA 02114. RP CALLAHAN, RJ (reprint author), MASSACHUSETTS GEN HOSP,32 FRUIT ST,BOSTON,MA 02114, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD DEC PY 1990 VL 31 IS 12 BP 2044 EP 2045 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EN644 UT WOS:A1990EN64400034 PM 2266406 ER PT J AU MULLEY, AG AF MULLEY, AG TI SUPPORTING THE PATIENTS ROLE IN DECISION-MAKING SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article RP MULLEY, AG (reprint author), MASSACHUSETTS GEN HOSP,GEN INTERNAL MED UNIT,BOSTON,MA 02114, USA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD DEC PY 1990 VL 32 IS 12 BP 1227 EP 1228 DI 10.1097/00043764-199012000-00019 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EM552 UT WOS:A1990EM55200015 PM 2292743 ER PT J AU NERY, EB LEE, KK CZAJKOWSKI, S DOONER, JJ DUGGAN, M ELLINGER, RF HENKIN, JM HINES, R MILLER, M OLSON, JW RAFFERTY, M SULLIVAN, T WALTERS, P WELCH, D WILLIAMS, A AF NERY, EB LEE, KK CZAJKOWSKI, S DOONER, JJ DUGGAN, M ELLINGER, RF HENKIN, JM HINES, R MILLER, M OLSON, JW RAFFERTY, M SULLIVAN, T WALTERS, P WELCH, D WILLIAMS, A TI A VETERANS-ADMINISTRATION COOPERATIVE STUDY OF BIPHASIC CALCIUM-PHOSPHATE CERAMIC IN PERIODONTAL OSSEOUS DEFECTS SO JOURNAL OF PERIODONTOLOGY LA English DT Article C1 VET ADM MED CTR,BATH,NY. VET ADM MED CTR,LEAVENWORTH,KS. VET ADM MED CTR,SAN ANTONIO,TX. VET ADM COOPERAT STUDY PROGRAM,CTR COORDINATING,PALO ALTO,CA. VET ADM MED CTR,MIAMI,FL 33125. VET ADM MED CTR,KANSAS CITY,MO 64128. VET ADM MED CTR,CLEVELAND,OH 44106. VET ADM MED CTR,LOUISVILLE,KY 40202. VET ADM MED CTR,BIRMINGHAM,AL 35233. VET ADM MED CTR,BROCKTON,MA 02401. VET ADM MED CTR W ROXBURY,BOSTON,MA 02132. RP NERY, EB (reprint author), CLEMENT J ZABLOCKI VET ADM,DENT RES SECT 151,MILWAUKEE,WI 53295, USA. NR 56 TC 33 Z9 33 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD DEC PY 1990 VL 61 IS 12 BP 737 EP 744 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EM128 UT WOS:A1990EM12800004 PM 2269915 ER PT J AU YASUDA, T GOLD, HK LEINBACH, RC SAITO, T GUERRERO, JL JANG, IK HOLT, R FALLON, JT COLLEN, D AF YASUDA, T GOLD, HK LEINBACH, RC SAITO, T GUERRERO, JL JANG, IK HOLT, R FALLON, JT COLLEN, D TI LYSIS OF PLASMINOGEN ACTIVATOR-RESISTANT PLATELET-RICH CORONARY-ARTERY THROMBUS WITH COMBINED BOLUS INJECTION OF RECOMBINANT TISSUE-TYPE PLASMINOGEN-ACTIVATOR AND ANTIPLATELET GPIIB/IIIA ANTIBODY SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID ACUTE MYOCARDIAL-INFARCTION; THROMBOLYTIC THERAPY; PROSTACYCLIN; REOCCLUSION; REDUCTION; INFUSION; STENOSIS; DOGS AB Resistance of coronary occlusive thrombus to thrombolytic therapy, found in some patients with acute myocardial infarction, may be due to the presence of platelet-rich coronary clot. Reperfusion therapy in such patients may require the development and evaluation of alternative strategies in animal models. Therefore, platelet-rich coronary artery thrombus was developed by excision, eversion (inside out) and reanastomosis of a 1 cm segment of the left circumflex coronary artery in anesthetized dogs maintained on heparin anticoagulation. Blood flow was restored in 25 of 27 dogs. Thrombotic occlusion of the everted segment graft with primarily platelet-rich thrombus or thrombus containing platelet-rich and erythrocyte-rich zones, persisting for at least 30 min, occurred with 4.5 +/- 3.5 min (mean +/- SD) in 20 of these 25 dogs. In 5 of these 20 dogs (group I, control), stable occlusion, as monitored with an ultrasound flow probe and coronary angiography, was maintained during a 2 h observation period. In group II (n = 5), intravenous bolus injections of recombinant tissue-type plasminogen activator (rt-PA) at a dose of 0.45 mg/kg body weight at four 15 min intervals did not cause reperfusion in four dogs and produced cyclic reperfusion and reocclusion in one dog. In group III (n = 5), a single intravenous bolus injection of 0.8 mg/kg of the F(ab')2 fragment of a murine monoclonal antibody (7E3) against the human platelet GPIIb/IIIa receptor [7E3-F(ab')2] produced stable reperfusion in two of the five dogs, whereas occlusion persisted in the other three. In group IV (n = 5), injection of 7E3-F(ab')2 (0.8 mg/kg) followed by rt-PA (0.45 mg/kg) caused stable reperfusion without reocclusion in all dogs (p < 0.05 versus rt-PA alone and p < 0.01 versus control). This study confirms that platelet-rich occlusive coronary thrombus is very resistant to lysis with intravenous rt-PA. However, this resistance may be overcome by the combined use of a reduced dose of rt-PA and the antiplatelet GPIIb/IIIa receptor antibody 7E3. The results indicate that platelet-rich thrombus resistant to thrombolytic agents may be dispersed pharmacologically without resort to mechanical recanalization. The present dog model may be useful in investigating specific strategies for the dispersion of resistant platelet-rich coronary thrombus. C1 MASSACHUSETTS GEN HOSP,DIV CARDIAC,CARDIAC UNIT,15 PARKMAN ST,BOSTON,MA 02114. UNIV VERMONT,COLL MED,DEPT BIOCHEM,BURLINGTON,VT 05405. UNIV VERMONT,COLL MED,DEPT MED,BURLINGTON,VT 05405. MASSACHUSETTS GEN HOSP,DEPT MED,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. FU NHLBI NIH HHS [HL26215, HL35058] NR 26 TC 101 Z9 105 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD DEC PY 1990 VL 16 IS 7 BP 1728 EP 1735 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EP099 UT WOS:A1990EP09900034 PM 2123910 ER PT J AU HARRIS, JE AF HARRIS, JE TI REPORTING DELAYS AND THE INCIDENCE OF AIDS SO JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION LA English DT Article C1 MASSACHUSETTS GEN HOSP,MED SERV,BOSTON,MA 02114. RP HARRIS, JE (reprint author), MIT,DEPT ECON,CAMBRIDGE,MA 02139, USA. NR 25 TC 35 Z9 36 U1 0 U2 0 PU AMER STATIST ASSN PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0162-1459 J9 J AM STAT ASSOC JI J. Am. Stat. Assoc. PD DEC PY 1990 VL 85 IS 412 BP 915 EP 924 DI 10.2307/2289588 PG 10 WC Statistics & Probability SC Mathematics GA EN054 UT WOS:A1990EN05400001 ER PT J AU SLEEPER, LA HARRINGTON, DP AF SLEEPER, LA HARRINGTON, DP TI REGRESSION SPLINES IN THE COX MODEL WITH APPLICATION TO COVARIATE EFFECTS IN LIVER-DISEASE SO JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION LA English DT Article C1 HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. RP SLEEPER, LA (reprint author), NEW ENGLAND RES INST,WATERTOWN,MA 02172, USA. NR 24 TC 77 Z9 77 U1 0 U2 3 PU AMER STATIST ASSN PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0162-1459 J9 J AM STAT ASSOC JI J. Am. Stat. Assoc. PD DEC PY 1990 VL 85 IS 412 BP 941 EP 949 DI 10.2307/2289591 PG 9 WC Statistics & Probability SC Mathematics GA EN054 UT WOS:A1990EN05400004 ER PT J AU TUNG, GA PAPANICOLAOU, N AF TUNG, GA PAPANICOLAOU, N TI PYOCYSTIS WITH URETHRAL OBSTRUCTION - PERCUTANEOUS CYSTOSTOMY AS AN ALTERNATIVE TO SURGERY SO JOURNAL OF THE CANADIAN ASSOCIATION OF RADIOLOGISTS-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES LA English DT Article DE PYOCYSTITIS; URINARY TRACT INFECTIONS; URETHRAL OBSTRUCTION; PERCUTANEOUS DRAINAGE; URINARY CATHETERIZATION AB Three patients with pyocystis and urethral obstruction were successfully treated with percutaneous placement of a suprapublic cystostomy catheter. This approach is an alternative to transurethral bladder irrigation or cystectomy in selected patients. C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,DIV GENITOURINARY RADIOL,BOSTON,MA 02114. NR 8 TC 5 Z9 5 U1 0 U2 0 PU CANADIAN MEDICAL ASSOCIATION PI OTTAWA PA 1867 ALTA VISTA DR, OTTAWA ON K1G 3Y6, CANADA SN 0008-2902 J9 J CAN ASSOC RADIOL PD DEC PY 1990 VL 41 IS 6 BP 350 EP 352 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EW149 UT WOS:A1990EW14900004 ER PT J AU BURKE, JF AF BURKE, JF TI FROM DESPERATION TO SKIN REGENERATION - PROGRESS IN BURN-TREATMENT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT CONF ON ADVANCES IN UNDERSTANDING TRAUMA AND BURN INJURY CY JUN 21-23, 1990 CL WASHINGTON, DC SP NIGMS, NIH, US DEPT HLTH & HUMAN SERV, INT SOC BURN INJURIES ID PROMPT ESCHAR EXCISION; ARTIFICIAL SKIN; MORTALITY; SURVIVAL; INJURIES RP BURKE, JF (reprint author), MASSACHUSETTS GEN HOSP,TRAUMA SERV,BIGELOW 1302,FRUIT ST,BOSTON,MA 02114, USA. FU NIGMS NIH HHS [5-P50-GM21700-14] NR 27 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 1990 VL 30 IS 12 SU S BP S36 EP S40 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA EQ497 UT WOS:A1990EQ49700010 PM 2254988 ER PT J AU BLYTH, B MANDELL, J BAUER, SB COLODNY, AH GRIER, HE WEINSTEIN, HJ TARBELL, NJ HENDREN, WH RETIK, AB AF BLYTH, B MANDELL, J BAUER, SB COLODNY, AH GRIER, HE WEINSTEIN, HJ TARBELL, NJ HENDREN, WH RETIK, AB TI PARATESTICULAR RHABDOMYOSARCOMA - RESULTS OF THERAPY IN 18 CASES SO JOURNAL OF UROLOGY LA English DT Article C1 HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT SURG,DIV UROL,300 LONGWOOD AVE,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,JOINT CTR RADIAT THERAPY,BOSTON,MA 02115. NR 10 TC 17 Z9 18 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 1990 VL 144 IS 6 BP 1450 EP 1453 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA EK579 UT WOS:A1990EK57900035 PM 2122010 ER PT J AU OLSHEVSKY, U HELSETH, E FURMAN, C LI, J HASELTINE, W SODROSKI, J AF OLSHEVSKY, U HELSETH, E FURMAN, C LI, J HASELTINE, W SODROSKI, J TI IDENTIFICATION OF INDIVIDUAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 AMINO-ACIDS IMPORTANT FOR CD4 RECEPTOR-BINDING SO JOURNAL OF VIROLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PATHOL,HUMAN RETROVIROL LAB,BOSTON,MA 02115. HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115. FU NIAID NIH HHS [AI24755] NR 37 TC 382 Z9 384 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 5701 EP 5707 PG 7 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200002 PM 2243375 ER PT J AU GOODRICH, LD SCHAFFER, PA DORSKY, DI CRUMPACKER, CS PARRIS, DS AF GOODRICH, LD SCHAFFER, PA DORSKY, DI CRUMPACKER, CS PARRIS, DS TI LOCALIZATION OF THE HERPES-SIMPLEX VIRUS TYPE-1 65-KILODALTON DNA-BINDING PROTEIN AND DNA-POLYMERASE IN THE PRESENCE AND ABSENCE OF VIRAL-DNA SYNTHESIS SO JOURNAL OF VIROLOGY LA English DT Article C1 OHIO STATE UNIV,PROGRAM MOLEC CELLULAR & DEV BIOL,COLUMBUS,OH 43210. OHIO STATE UNIV,DEPT MED MICROBIOL & IMMUNOL,COLUMBUS,OH 43210. OHIO STATE UNIV,CTR COMPREHENS CANC,COLUMBUS,OH 43210. HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV INFECT DIS,BOSTON,MA 02215. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,TUMOR VIRUS GENET LAB,BOSTON,MA 02115. UNIV CONNECTICUT,CTR HLTH,DIV INFECT DIS,FARMINGTON,CT 06032. FU NCI NIH HHS [CA 16958]; NIAID NIH HHS [AI 28537]; NIGMS NIH HHS [GM 34930] NR 40 TC 42 Z9 43 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 5738 EP 5749 PG 12 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200006 PM 2173766 ER PT J AU HELSETH, E OLSHEVSKY, U GABUZDA, D ARDMAN, B HASELTINE, W SODROSKI, J AF HELSETH, E OLSHEVSKY, U GABUZDA, D ARDMAN, B HASELTINE, W SODROSKI, J TI CHANGES IN THE TRANSMEMBRANE REGION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP41 ENVELOPE GLYCOPROTEIN AFFECT MEMBRANE-FUSION SO JOURNAL OF VIROLOGY LA English DT Note C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PATHOL,DIV HUMAN RETROVIROL,44 BINNEY ST,BOSTON,MA 02115. NEW ENGLAND MED CTR HOSP,DEPT MED,DIV HEMATOL ONCOL,BOSTON,MA 02111. HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115. FU NIAID NIH HHS [AI24755, AI27729] NR 24 TC 120 Z9 121 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1990 VL 64 IS 12 BP 6314 EP 6318 PG 5 WC Virology SC Virology GA EJ202 UT WOS:A1990EJ20200073 PM 2243396 ER PT J AU METSON, R AF METSON, R TI THE ENDOSCOPIC APPROACH FOR REVISION DACRYOCYSTORHINOSTOMY SO LARYNGOSCOPE LA English DT Article C1 HARVARD UNIV,SCH MED,MASSACHUSETTS EYE & EAR INFIRM,DEPT OTOL & LARYNGOL,BOSTON,MA 02115. NR 8 TC 54 Z9 59 U1 0 U2 0 PU LARYNGOSCOPE CO PI ST LOUIS PA 10 S BROADWAY 14TH FLOOR, ST LOUIS, MO 63102-1741 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 1990 VL 100 IS 12 BP 1344 EP 1347 PG 4 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA EL320 UT WOS:A1990EL32000019 PM 2243532 ER PT J AU STONE, RM SPRIGGS, DR DHAWAN, RK ARTHUR, KA MAYER, RJ KUFE, DW AF STONE, RM SPRIGGS, DR DHAWAN, RK ARTHUR, KA MAYER, RJ KUFE, DW TI A PHASE-I STUDY OF INTERMITTENT CONTINUOUS INFUSION HIGH-DOSE CYTOSINE-ARABINOSIDE FOR ACUTE-LEUKEMIA SO LEUKEMIA LA English DT Article ID NERVOUS-SYSTEM TOXICITY; ARA-C; 1-BETA-D-ARABINOFURANOSYLCYTOSINE INCORPORATION; CONSOLIDATION THERAPY; REFRACTORY LEUKEMIA; CYTARABINE; REMISSION; LYMPHOMA; CELLS AB We previously administered ara-C at a dose rate of 250 mg/m2/hr for 36-72 hr to patients with leukemia. Gastrointestinal toxicity was dose-limiting. This regimen was modified to an every other day schedule, administering 24-hr periods of high dose continuous infusion ara-C, each followed by a 24-hr rest period. Sixteen patients with relapsed/refractory acute myeloid leukemia (AML) (N = 4), secondary AML (N = 2), relapsed/refractory acute lymphoblastic leukemia (N = 7), or CML in blast crisis (N = 3) received this regimen of three 24-hr infusions with two intercurrent 24-hr rest periods. Grade 3 gastrointestinal toxicity was encountered in 57% of the courses and hypoplasia was achieved in all patients. Three of the patients died while hypoplastic, two with septicemia and another with intracranial hemorrhage. There were five responding patients (2 CRs, 3 PRs). Median steady-state plasma ara-C levels were 24-mu-M, 22-mu-M, and 20-mu-M during the first, second, and third 24-hr infusions, respectively. Ara-C levels ranged from 4-118-mu-M during the infusions and were always below 4.5-mu-M during the rest periods. A significant level of ara-C incorporation into DNA was detected in each of the five patients studied, thus demonstrating that (ara-C)DNA formation is detectable in blasts from patients receiving high dose continuous infusion ara-C therapy. These findings suggest that alternate day continuous infusion ara-C may be useful in the treatment of acute leukemia and CML in blast crisis. RP STONE, RM (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,CLIN PHARMACOL LAB,44 BINNEY ST,BOSTON,MA 02115, USA. FU NCI NIH HHS [P0-1 CA34183, CA29431] NR 27 TC 6 Z9 6 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0887-6924 J9 LEUKEMIA JI Leukemia PD DEC PY 1990 VL 4 IS 12 BP 843 EP 847 PG 5 WC Oncology; Hematology SC Oncology; Hematology GA EQ200 UT WOS:A1990EQ20000010 PM 2243507 ER PT J AU MILLER, AL HATCH, JP PRIHODA, TJ AF MILLER, AL HATCH, JP PRIHODA, TJ TI DICHLOROACETATE INCREASES GLUCOSE USE AND DECREASES LACTATE IN DEVELOPING RAT-BRAIN SO METABOLIC BRAIN DISEASE LA English DT Article DE GLUCOSE; DICHLOROACETATE; BRAIN; DEVELOPMENT; LACTATE ID PYRUVATE-DEHYDROGENASE ACTIVITY; ISCHEMIC CELL-DAMAGE; LACTIC-ACIDOSIS; BLOOD-GLUCOSE; METABOLISM; HYPERCAPNIA; PHOSPHORYLATION; ACCUMULATION; MITOCHONDRIA; REPERFUSION AB Dichloroacetate (DCA) activates pyruvate dehydrogenase (PDH) by inhibiting PDH kinase. Neutralized DCA (100 mg/kg) or saline was intravenously administered to 20 to 25-day-old rats (50-75 g). Fifteen minutes later a mixture of [6-C-14]glucose and [H-3]fluorodeoxyglucose (FDG) was administered intravenously and the animals were sacrificed by microwave irradiation (2450 MHz, 8.0 kW, 0.6-0.8 sec) after 2 or 5 min. Brain regional rates of glucose use and metabolite levels were determined. DCA-treated rats had increased rates of glucose use in all regions studied (cortex, thalamus, striatum, and brain stem), with an average increase of 41%. Lactate levels were lower in all regions, by an average of 35%. There were no significant changes in levels of ATP, creatine phosphate, or glycogen in any brain region. Blood levels of lactate did not differ significantly between the DCA- and the saline-treated groups. Blood glucose levels were higher in the DCA group. In rats sacrified by freeze-blowing, DCA treatment caused lower brain levels of both lactate and pyruvate. These results cannot be explained by any systemic effect of DCA. Rather, it appears that in the immature rat, DCA treatment results in activation of brain PDH, increased metabolism of brain pyruvate and lactate, and a resulting increase in brain glycolytic rate. C1 AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284. RP MILLER, AL (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT PSYCHIAT,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. FU NICHD NIH HHS [HD 15053] NR 36 TC 6 Z9 6 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0885-7490 J9 METAB BRAIN DIS JI Metab. Brain Dis. PD DEC PY 1990 VL 5 IS 4 BP 195 EP 204 DI 10.1007/BF00997073 PG 10 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA FB708 UT WOS:A1990FB70800004 PM 2087218 ER PT J AU LARIVIERE, F WAGNER, DA KUPRANYCZ, D HOFFER, LJ AF LARIVIERE, F WAGNER, DA KUPRANYCZ, D HOFFER, LJ TI PROLONGED FASTING AS CONDITIONED BY PRIOR PROTEIN DEPLETION - EFFECT ON URINARY NITROGEN-EXCRETION AND WHOLE-BODY PROTEIN-TURNOVER SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article C1 ROYAL VICTORIA HOSP,MCGILL NUTR & FOOD SCI CTR,687 PINE AVE W,MONTREAL H3A 1A1,QUEBEC,CANADA. SHRINERS BURN INST,MASS SPECTROMETRY LAB,BOSTON,MA. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HOP HOTEL DIEU,RECH GRP,MONTREAL H2W 1T8,QUEBEC,CANADA. NR 47 TC 6 Z9 6 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0026-0495 J9 METABOLISM JI Metab.-Clin. Exp. PD DEC PY 1990 VL 39 IS 12 BP 1270 EP 1277 DI 10.1016/0026-0495(90)90183-D PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EL396 UT WOS:A1990EL39600010 PM 2246967 ER PT J AU OHTA, T ISSELBACHER, KJ RHOADS, DB AF OHTA, T ISSELBACHER, KJ RHOADS, DB TI REGULATION OF GLUCOSE TRANSPORTERS IN LLC-PK1 CELLS - EFFECTS OF D-GLUCOSE AND MONOSACCHARIDES SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,CTR CANC,GASTROINTESTINAL ONCOL LAB,BOSTON,MA 02129. HAYASHIBARA BIOCHEM LABS INC,FUJISAKI INST,OKAYAMA 702,JAPAN. FU NIDDK NIH HHS [DK01392-34] NR 47 TC 99 Z9 100 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6491 EP 6499 PG 9 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200042 PM 2247068 ER PT J AU WANG, CY KELLY, J BOWENPOPE, DF STILES, CD AF WANG, CY KELLY, J BOWENPOPE, DF STILES, CD TI RETINOIC ACID PROMOTES TRANSCRIPTION OF THE PLATELET-DERIVED GROWTH-FACTOR ALPHA-RECEPTOR GENE SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Note C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELLULAR & MOLEC BIOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115. UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195. NR 28 TC 41 Z9 44 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6781 EP 6784 PG 4 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200074 PM 2174116 ER PT J AU KNEPEL, W CHAFITZ, J HABENER, JF AF KNEPEL, W CHAFITZ, J HABENER, JF TI TRANSCRIPTIONAL ACTIVATION OF THE RAT GLUCAGON GENE BY THE CYCLIC AMP-RESPONSIVE ELEMENT IN PANCREATIC-ISLET CELLS SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Note C1 HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02115. RP KNEPEL, W (reprint author), MASSACHUSETTS GEN HOSP,MOLEC ENDOCRINOL LAB,BOSTON,MA 02114, USA. FU NIDDK NIH HHS [DK 30834] NR 28 TC 70 Z9 70 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 1990 VL 10 IS 12 BP 6799 EP 6804 PG 6 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ602 UT WOS:A1990EJ60200077 PM 2147227 ER PT J AU BRASIER, AR RON, D TATE, JE HABENER, JF AF BRASIER, AR RON, D TATE, JE HABENER, JF TI SYNERGISTIC ENHANSONS LOCATED WITHIN AN ACUTE PHASE RESPONSIVE ENHANCER MODULATE GLUCOCORTICOID INDUCTION OF ANGIOTENSINOGEN GENE-TRANSCRIPTION SO MOLECULAR ENDOCRINOLOGY LA English DT Article ID MAMMARY-TUMOR VIRUS; RIBONUCLEIC-ACID; HEPATOMA-CELLS; RECEPTOR BINDS; MESSENGER-RNA; RAT; EXPRESSION; ELEMENTS; PROMOTER; COOPERATIVITY AB The hepatic transcription of the angiotensinogen gene is regulated by both glucocorticoids and cytokines generated as products of the acute phase reaction. We have identified a multimodular enhancer in the 5'-flanking region of the rat angiotensinogen gene that mediates these responses and consists of an acute phase response element (APRE) flanked on both sides by adjacent glucocorticoid response element consensus motifs (GREs). Induction of transcription by the cytokine interleukin-1 (IL-1) is glucocorticoid dependent and mediated through the APRE. The APRE binds in a mutually exclusive manner a cytokine/phorbol ester-inducible protein (BPi), indistinguishable from nuclear factor kB, and a family of constitutive liver proteins (BPcs) related to the heat-stable transcription factor C/EBP. Using mutated 5'-flanking sequences of the angiotensinogen gene fused to a firefly luciferase reporter gene transfected into hepatoblastoma (HepG2) cells, we have mapped enhanson sequences required for the transcriptional response to glucocorticoids. Two functionally distinct GREs are identified by deletion and site-directed mutagenesis, both of which mediate glucocorticoid-stimulated transcription in vivo. Glucocorticoid-induced transcription mediated by the angiotensinogen gene enhances is, furthermore, dependent on the occupancy of the APRE by either the BPi or a member of the BPc family because a mutant APRE that binds neither BPi nor BPc exhibits an attenuated glucocorticoid responsiveness. Mutant APREs that permit exclusive binding of either BPi or BPc synergistically transmit the glucocorticoid response mediated by one or the other of the adjacent GREs. Thus the induction of angiotensinogen gene transcription involves interaction between the glucocorticoid receptor and either one of the APRE-binding proteins: either the cytokine-inducible NFkB or the constitutive family of C/EBP-like proteins, bound to adjacent enhansons in a mutually synergistic enhancer complex. (Molecular Endocrinology 4: 1921-1933, 1990) C1 HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02115. RP BRASIER, AR (reprint author), MASSACHUSETTS GEN HOSP,MOLEC ENDOCRINOL LAB,BOSTON,MA 02114, USA. FU NIDDK NIH HHS [DK-30834] NR 48 TC 35 Z9 35 U1 0 U2 1 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0888-8809 J9 MOL ENDOCRINOL JI Mol. Endocrinol. PD DEC PY 1990 VL 4 IS 12 BP 1921 EP 1933 PG 13 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EQ428 UT WOS:A1990EQ42800019 PM 1707127 ER PT J AU SKLAR, RM BEGGS, AH LEV, AA SPECHT, L SHAPIRO, F BROWN, RH AF SKLAR, RM BEGGS, AH LEV, AA SPECHT, L SHAPIRO, F BROWN, RH TI DEFECTIVE DYSTROPHIN IN DUCHENNE AND BECKER DYSTROPHY MYOTUBES IN CELL-CULTURE SO NEUROLOGY LA English DT Article C1 CHILDRENS HOSP MED CTR,DEPT GENET,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,DEPT NEUROL,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,DEPT ORTHOPED SURG,BOSTON,MA 02115. RP SKLAR, RM (reprint author), MASSACHUSETTS GEN HOSP,CECIL B DAY NEUROMUSCULAR RES LABS,BLDG 149,13TH ST,NAVY YARD,BOSTON,MA 02129, USA. OI Beggs, Alan/0000-0001-8818-0568 FU NINDS NIH HHS [5-KO8-NS01254, R01 NS 00787-05] NR 27 TC 14 Z9 14 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0028-3878 J9 NEUROLOGY JI Neurology PD DEC PY 1990 VL 40 IS 12 BP 1854 EP 1858 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA EL955 UT WOS:A1990EL95500012 PM 1701042 ER PT J AU RICHARDSON, EP AF RICHARDSON, EP TI HUNTINGTONS-DISEASE - SOME RECENT NEUROPATHOLOGICAL STUDIES SO NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY LA English DT Editorial Material DE BRAIN DISEASES; BASAL GANGLIA DISEASES; CORPUS STRIATUM; HUNTINGTONS CHOREA; CLASSIFICATION; IMMUNOENZYME TECHNIQUES; CEREBRAL CORTEX; SUBSTANTIA NIGRA ID STRIATAL NEURONS; NEOSTRIATUM RP RICHARDSON, EP (reprint author), MASSACHUSETTS GEN HOSP,CS KUBIK LAB NEUROPATHOL,BOSTON,MA 02114, USA. NR 21 TC 18 Z9 18 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0305-1846 J9 NEUROPATH APPL NEURO JI Neuropathol. Appl. Neurobiol. PD DEC PY 1990 VL 16 IS 6 BP 451 EP 460 DI 10.1111/j.1365-2990.1990.tb01285.x PG 10 WC Clinical Neurology; Neurosciences; Pathology SC Neurosciences & Neurology; Pathology GA EN853 UT WOS:A1990EN85300001 PM 2151398 ER PT J AU HORTON, JC CHAMBERS, WA LYONS, SL ADAMS, RD KJELLBERG, RN AF HORTON, JC CHAMBERS, WA LYONS, SL ADAMS, RD KJELLBERG, RN TI PREGNANCY AND THE RISK OF HEMORRHAGE FROM CEREBRAL ARTERIOVENOUS-MALFORMATIONS SO NEUROSURGERY LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT NEUROL & NEUROSURG,BOSTON,MA 02114. GEORGE WASHINGTON UNIV,DEPT COMP MED,WASHINGTON,DC 20052. NR 32 TC 105 Z9 114 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD DEC PY 1990 VL 27 IS 6 BP 867 EP 872 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA EL269 UT WOS:A1990EL26900002 PM 2274126 ER PT J AU NETLAND, PA TOWNSEND, DJ ALBERT, DM JAKOBIEC, FA AF NETLAND, PA TOWNSEND, DJ ALBERT, DM JAKOBIEC, FA TI HIDRADENOMA PAPILLIFERUM OF THE UPPER EYELID ARISING FROM THE APOCRINE GLAND OF MOLL SO OPHTHALMOLOGY LA English DT Article C1 MASSACHUSSETTS EYE & EAR INFIRM,DEPT OPHTHALMOL,243 CHARLES ST,BOSTON,MA 02115. NR 14 TC 13 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD DEC PY 1990 VL 97 IS 12 BP 1593 EP 1598 PG 6 WC Ophthalmology SC Ophthalmology GA EL958 UT WOS:A1990EL95800006 PM 1965020 ER PT J AU STACK, WE TAUBMAN, MA TSUKUDA, T SMITH, DJ EBERSOLE, JL KENT, R AF STACK, WE TAUBMAN, MA TSUKUDA, T SMITH, DJ EBERSOLE, JL KENT, R TI DENTAL-CARIES IN CONGENITALLY ATHYMIC RATS SO ORAL MICROBIOLOGY AND IMMUNOLOGY LA English DT Article C1 FORSYTH DENT CTR,140 FENWAY,BOSTON,MA 02115. FU NIDCR NIH HHS [DE04733] NR 0 TC 15 Z9 17 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0902-0055 J9 ORAL MICROBIOL IMMUN JI Oral Microbiol. Immunol. PD DEC PY 1990 VL 5 IS 6 BP 309 EP 314 DI 10.1111/j.1399-302X.1990.tb00431.x PG 6 WC Dentistry, Oral Surgery & Medicine; Immunology; Microbiology SC Dentistry, Oral Surgery & Medicine; Immunology; Microbiology GA EM892 UT WOS:A1990EM89200002 PM 2098708 ER PT J AU ADLER, RS JELLINEK, MS AF ADLER, RS JELLINEK, MS TI AFTER TEEN SUICIDE - ISSUES FOR PEDIATRICIANS WHO ARE ASKED TO CONSULT TO SCHOOLS SO PEDIATRICS LA English DT Article C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. RP ADLER, RS (reprint author), SOMERSET CTY HLTH DEPT,POB 129,WESTOVER,MD 21871, USA. NR 16 TC 6 Z9 6 U1 0 U2 2 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD DEC PY 1990 VL 86 IS 6 BP 982 EP 987 PG 6 WC Pediatrics SC Pediatrics GA EL925 UT WOS:A1990EL92500022 PM 2251035 ER PT J AU PERRIN, JM AF PERRIN, JM TI CHILDREN WITH SPECIAL HEALTH NEEDS - A UNITED-STATES PERSPECTIVE SO PEDIATRICS LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP PERRIN, JM (reprint author), MASSACHUSETTS GEN HOSP,AMBULATORY CARE PROGRAMS & GEN PEDIAT CHILDRENS SERV,BOSTON,MA 02114, USA. NR 18 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD DEC PY 1990 VL 86 IS 6 SU S BP 1120 EP 1123 PG 4 WC Pediatrics SC Pediatrics GA EM228 UT WOS:A1990EM22800024 PM 2243752 ER PT J AU BRADLEY, DW DOU, QP FRIDOVICHKEIL, JL PARDEE, AB AF BRADLEY, DW DOU, QP FRIDOVICHKEIL, JL PARDEE, AB TI TRANSFORMED AND NONTRANSFORMED CELLS DIFFER IN STABILITY AND CELL-CYCLE REGULATION OF A BINDING-ACTIVITY TO THE MURINE THYMIDINE KINASE PROMOTER SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,44 BINNEY ST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,PROGRAM CELL & DEV BIOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELL GROWTH & REGULAT,BOSTON,MA 02115. FU NIGMS NIH HHS [GM24571] NR 27 TC 33 Z9 33 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9310 EP 9314 DI 10.1073/pnas.87.23.9310 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600049 PM 2251273 ER PT J AU FLEMINGTON, E SPECK, SH AF FLEMINGTON, E SPECK, SH TI EVIDENCE FOR COILED-COIL DIMER FORMATION BY AN EPSTEIN-BARR-VIRUS TRANSACTIVATOR THAT LACKS A HEPTAD REPEAT OF LEUCINE RESIDUES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. RP FLEMINGTON, E (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR VIROL,44 BINNEY ST,BOSTON,MA 02115, USA. FU NCI NIH HHS [CA43143, 1 F32 CA08482, CA52004] NR 23 TC 96 Z9 97 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 23 BP 9459 EP 9463 DI 10.1073/pnas.87.23.9459 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL366 UT WOS:A1990EL36600080 PM 2174563 ER PT J AU ROSS, SR GRAVES, RA GREENSTEIN, A PLATT, KA SHYU, HL MELLOVITZ, B SPIEGELMAN, BM AF ROSS, SR GRAVES, RA GREENSTEIN, A PLATT, KA SHYU, HL MELLOVITZ, B SPIEGELMAN, BM TI A FAT-SPECIFIC ENHANCER IS THE PRIMARY DETERMINANT OF GENE-EXPRESSION FOR ADIPOCYTE-P2 INVIVO SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. RP ROSS, SR (reprint author), UNIV ILLINOIS,DEPT BIOCHEM,CHICAGO,IL 60612, USA. FU NIDDK NIH HHS [DK31405] NR 24 TC 177 Z9 181 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9590 EP 9594 DI 10.1073/pnas.87.24.9590 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900018 PM 2263614 ER PT J AU PROPST, F ROSENBERG, MP CORK, LC KOVATCH, RM RAUCH, S WESTPHAL, H KHILLAN, J SCHULZ, NT VANDEWOUDE, GF NEWMANN, PE AF PROPST, F ROSENBERG, MP CORK, LC KOVATCH, RM RAUCH, S WESTPHAL, H KHILLAN, J SCHULZ, NT VANDEWOUDE, GF NEWMANN, PE TI NEUROPATHOLOGICAL CHANGES IN TRANSGENIC MICE CARRYING COPIES OF A TRANSCRIPTIONALLY ACTIVATED MOS PROTOONCOGENE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,POB B,FREDERICK,MD 21701. JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,BALTIMORE,MD 21205. PATHOL ASSOCIATES INC,FREDERICK,MD 21701. HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,DEPT OTOLARYNGOL,BOSTON,MA 02215. NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892. THOMAS JEFFERSON UNIV,PHILADELPHIA,PA 19107. CHILDRENS HOSP MED CTR,BOSTON,MA 02115. FU NCI NIH HHS [N01-CO-74101]; NIGMS NIH HHS [GM20919]; NINDS NIH HHS [NS20820] NR 29 TC 32 Z9 32 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9703 EP 9707 DI 10.1073/pnas.87.24.9703 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900041 PM 1702218 ER PT J AU CICCONE, E COLONNA, M VIALE, O PENDE, D DIDONATO, C REINHARZ, D AMOROSO, A JEANNET, M GUARDIOLA, J MORETTA, A SPIES, T STROMINGER, J MORETTA, L AF CICCONE, E COLONNA, M VIALE, O PENDE, D DIDONATO, C REINHARZ, D AMOROSO, A JEANNET, M GUARDIOLA, J MORETTA, A SPIES, T STROMINGER, J MORETTA, L TI SUSCEPTIBILITY OR RESISTANCE TO LYSIS BY ALLOREACTIVE NATURAL-KILLER-CELLS IS GOVERNED BY A GENE IN THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX BETWEEN BF AND HLA-B SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article C1 UNIV GENOA, CTR INTERUNIV RIC CANC, I-16126 GENOA, ITALY. UNIV GENOA, IST ISTOL & EMBRIOL GEN, I-16126 GENOA, ITALY. HOP CANTONAL GENEVA, UNITE IMMUNOL & TRANSPLANTAT, CH-1211 GENEVA 4, SWITZERLAND. UNIV TURIN, IST GENET MED, I-10124 TURIN, ITALY. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DIV TUMOR VIROL, BOSTON, MA 02115 USA. IST INT GENET & BIOFIS, NAPLES, ITALY. RP CICCONE, E (reprint author), UNIV GENOA, IST NAZL RIC CANC, I-16126 GENOA, ITALY. RI Pende, Daniela/J-7429-2016; OI Pende, Daniela/0000-0003-1565-451X; amoroso, antonio/0000-0002-9437-9407; Colonna, Marco/0000-0001-5222-4987 FU NCI NIH HHS [CA-47554] NR 16 TC 67 Z9 67 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC PY 1990 VL 87 IS 24 BP 9794 EP 9797 DI 10.1073/pnas.87.24.9794 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN159 UT WOS:A1990EN15900060 PM 1979875 ER PT J AU CASSEM, EH AF CASSEM, EH TI DEPRESSION AND ANXIETY SECONDARY TO MEDICAL ILLNESS SO PSYCHIATRIC CLINICS OF NORTH AMERICA LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP CASSEM, EH (reprint author), MASSACHUSETTS GEN HOSP,PSYCHIAT,BOSTON,MA 02114, USA. NR 49 TC 55 Z9 56 U1 2 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0193-953X J9 PSYCHIAT CLIN N AM JI Psychiatr. Clin. North Amer. PD DEC PY 1990 VL 13 IS 4 BP 597 EP 612 PG 16 WC Psychiatry SC Psychiatry GA EK213 UT WOS:A1990EK21300004 PM 2281008 ER PT J AU WILENS, TE STERN, TA AF WILENS, TE STERN, TA TI VENTRICULAR-TACHYCARDIA ASSOCIATED WITH DESIPRAMINE AND THIORIDAZINE SO PSYCHOSOMATICS LA English DT Article C1 MASSACHUSETTS GEN HOSP,WARREN 607,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,PSYCHIAT CONSULTAT SERV,BOSTON,MA 02114. NR 17 TC 6 Z9 6 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD WIN PY 1990 VL 31 IS 1 BP 100 EP 103 PG 4 WC Psychiatry; Psychology SC Psychiatry; Psychology GA CH451 UT WOS:A1990CH45100016 PM 2300645 ER PT J AU YUCEL, EK STEINBERG, FL EGGLIN, TK GELLER, SC WALTMAN, AC ATHANASOULIS, CA AF YUCEL, EK STEINBERG, FL EGGLIN, TK GELLER, SC WALTMAN, AC ATHANASOULIS, CA TI PENETRATING AORTIC ULCERS - DIAGNOSIS WITH MR IMAGING SO RADIOLOGY LA English DT Article RP YUCEL, EK (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114, USA. NR 11 TC 98 Z9 99 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD DEC PY 1990 VL 177 IS 3 BP 779 EP 781 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EJ926 UT WOS:A1990EJ92600035 PM 2243989 ER PT J AU KOPANS, DB NGUYEN, PL KOERNER, FC WHITE, G MCCARTHY, KA HALL, DA MROSE, H CARDENOSA, G PILESPELLMAN, E AF KOPANS, DB NGUYEN, PL KOERNER, FC WHITE, G MCCARTHY, KA HALL, DA MROSE, H CARDENOSA, G PILESPELLMAN, E TI MIXED FORM, DIFFUSELY SCATTERED CALCIFICATIONS IN BREAST-CANCER WITH APOCRINE FEATURES SO RADIOLOGY LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,CTR CANC,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. RP KOPANS, DB (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,32 FRUIT ST,BOSTON,MA 02114, USA. NR 11 TC 10 Z9 13 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD DEC PY 1990 VL 177 IS 3 BP 807 EP 811 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EJ926 UT WOS:A1990EJ92600041 PM 2173843 ER PT J AU THOMPSON, AR FALLON, J NUSSBAUM, S AF THOMPSON, AR FALLON, J NUSSBAUM, S TI EVALUATION OF METASTATIC CARDIAC CALCIFICATION IN A MODEL OF CHRONIC PRIMARY HYPERPARATHYROIDISM SO SURGERY LA English DT Article; Proceedings Paper CT 11TH ANNUAL MEETING OF THE AMERICAN ASSOC OF ENDOCRINE SURGEONS CY APR 22-24, 1990 CL CLEVELAND, OH SP AMER ASSOC ENDOCRINE SURGEONS C1 MASSACHUSETTS GEN HOSP,ENDOCRINE UNIT,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP THOMPSON, AR (reprint author), UNIV LOUISVILLE,DEPT SURG,LOUISVILLE,KY 40292, USA. NR 17 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD DEC PY 1990 VL 108 IS 6 BP 1047 EP 1051 PG 5 WC Surgery SC Surgery GA EL873 UT WOS:A1990EL87300016 PM 2247829 ER PT J AU SAUNDERS, KD CATES, JA ROSLYN, JJ AF SAUNDERS, KD CATES, JA ROSLYN, JJ TI PATHOGENESIS OF GALLSTONES SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Review C1 UNIV CALIF LOS ANGELES,SCH MED,DEPT SURG,72-236 CTR HLTH SCI,LOS ANGELES,CA 90024. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. VET ADM MED CTR,SEPULVEDA,CA 91343. NR 105 TC 20 Z9 20 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD DEC PY 1990 VL 70 IS 6 BP 1197 EP 1216 PG 20 WC Surgery SC Surgery GA EL864 UT WOS:A1990EL86400002 PM 2247810 ER PT J AU OLIVER, LC SPRINCE, NL GREENE, R AF OLIVER, LC SPRINCE, NL GREENE, R TI ASBESTOS-RELATED RADIOGRAPHIC ABNORMALITIES IN PUBLIC-SCHOOL CUSTODIANS SO TOXICOLOGY AND INDUSTRIAL HEALTH LA English DT Article DE ASBESTOS-CONTAINING MATERIAL (ACM); NO OUTSIDE EXPOSURE (NOE); PLEURAL PLAQUES; ANTERIOR OBLIQUE CHEST RADIOGRAPHS ID PREVALENCE; EXPOSURE; DISEASE AB A cross-sectional prevalence study of 120 public school custodians was carried out to investigate the prevalence of asbestos-related disease and to determine the proportion with disease attributable to asbestos exposures in school buildings. Medical and occupational histories, flow-volume loops, and posterior-anterior, lateral, and anterior oblique (AO) chest radiographs were obtained. Single breath DLCO was measured and chest auscultation performed. The present report describes radiographic abnormalities and associations with exposure. Mean age of subjects was 57 years and mean duration of work as a custodian, 27 years. Fifty-seven (47.5%) had no known or likely exposure to asbestos outside of their work as a school custodian (NOE). Pleural plaques (PP) occurred in 40 (33%) of the total group and 12 (21%) of the group with NOE. Multivariate analysis revealed significant associations (p < 0.05) between PP and duration of asbestos exposure. The proportion with PP increased with increasing years of latency. AO radiographs increased PP detection by a factor of 1.9. Our results reveal PP prevalence in excess of background in the study population and indicate that PP are attributable to asbestos exposure in schools in a subset with NOE. Prudent management of asbestos in buildings in indicated for the prevention of related disease. C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RP OLIVER, LC (reprint author), MASSACHUSETTS GEN HOSP,MED SERV,PULM & CRIT CARE UNIT,BOSTON,MA 02114, USA. NR 15 TC 5 Z9 6 U1 1 U2 1 PU PRINCETON SCIENTIFIC PUBL INC PI PRINCETON PA PO BOX 2155, PRINCETON, NJ 08543 SN 0748-2337 J9 TOXICOL IND HEALTH JI Toxicol. Ind. Health PD DEC PY 1990 VL 6 IS 6 BP 629 EP 636 PG 8 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA EZ231 UT WOS:A1990EZ23100007 PM 2097821 ER PT J AU BLATTER, DD CRAWFORD, JM FERRARA, JLM AF BLATTER, DD CRAWFORD, JM FERRARA, JLM TI NUCLEAR-MAGNETIC-RESONANCE OF HEPATIC GRAFT-VERSUS-HOST DISEASE IN MICE SO TRANSPLANTATION LA English DT Article ID MINOR HISTOCOMPATIBILITY BARRIERS; BONE-MARROW TRANSPLANTATION; CARDIAC ALLOGRAFT-REJECTION; FATTY LIVER INFILTRATION; BILE-DUCT; MURINE MODEL; RAT; SPECTROSCOPY; ANTIGENS; LESIONS AB The liver is a major target organ of graft-versus-host disease. We have induced graded intensities of acute GVHD to minor histocompatibility antigens in a well-characterized murine bone marrow transplant model and analyzed hepatic pathology one month after BMT. Nuclear-magnetic-resonance relaxation times and proton spectra were compared to systemic clinical disease, serum biochemistries, and histologic findings. T2 relaxation times correlated directly with the intensity of histologic abnormalities, but the hepatic histology remained mild even in animals with moderate GVHD. In contrast, NMR proton spectra of hepatic tissue showed large decreases in metabolite levels (acetate and glycogen) in animals with moderate systemic disease despite mild hepatic histology. We conclude that NMR of the liver can be used to differentiate hepatic from systemic GVHD in this model and may help to elucidate the differential effects of GVHD in various target organs. C1 BRIGHAM & WOMENS HOSP,DEPT RADIOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,DIV HEMATOL ONCOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115. FU NCI NIH HHS [P02CA18662]; NCRR NIH HHS [RR00995]; NIAID NIH HHS [K11 AI00653] NR 44 TC 17 Z9 17 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD DEC PY 1990 VL 50 IS 6 BP 1011 EP 1018 DI 10.1097/00007890-199012000-00023 PG 8 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA EN880 UT WOS:A1990EN88000023 PM 2256143 ER PT J AU PRASAD, VR MYRICK, K HASELTINE, W GOFF, SP AF PRASAD, VR MYRICK, K HASELTINE, W GOFF, SP TI EXPRESSION OF ENZYMATICALLY ACTIVE REVERSE-TRANSCRIPTASE OF SIMIAN IMMUNODEFICIENCY VIRUS IN BACTERIA - SENSITIVITY TO NUCLEOTIDE ANALOG INHIBITORS SO VIROLOGY LA English DT Note C1 COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM,NEW YORK,NY 10032. COLUMBIA UNIV COLL PHYS & SURG,DEPT MOLEC BIOPHYS,NEW YORK,NY 10032. COLUMBIA UNIV COLL PHYS & SURG,DEPT MICROBIOL,NEW YORK,NY 10032. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV HUMAN RETROVIROL,BOSTON,MA 02115. FU NIAID NIH HHS [1 UO1 AI 24845] NR 17 TC 3 Z9 3 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 1990 VL 179 IS 2 BP 896 EP 900 DI 10.1016/0042-6822(90)90164-M PG 5 WC Virology SC Virology GA EK040 UT WOS:A1990EK04000042 PM 1700544 ER PT J AU FINNEY, M RUVKUN, G AF FINNEY, M RUVKUN, G TI THE UNC-86 GENE-PRODUCT COUPLES CELL LINEAGE AND CELL IDENTITY IN C-ELEGANS SO CELL LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. RP FINNEY, M (reprint author), HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115, USA. NR 34 TC 473 Z9 480 U1 0 U2 6 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD NOV 30 PY 1990 VL 63 IS 5 BP 895 EP 905 DI 10.1016/0092-8674(90)90493-X PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EL759 UT WOS:A1990EL75900005 PM 2257628 ER PT J AU MALKIN, D LI, FP STRONG, LC FRAUMENI, JF NELSON, CE KIM, DH KASSEL, J GRYKA, MA BISCHOFF, FZ TAINSKY, MA FRIEND, SH AF MALKIN, D LI, FP STRONG, LC FRAUMENI, JF NELSON, CE KIM, DH KASSEL, J GRYKA, MA BISCHOFF, FZ TAINSKY, MA FRIEND, SH TI GERM LINE P53 MUTATIONS IN A FAMILIAL SYNDROME OF BREAST-CANCER, SARCOMAS, AND OTHER NEOPLASMS SO SCIENCE LA English DT Article C1 MASSACHUSETTS GEN HOSP,CTR CANC,DIV MOLEC GENET,MGH E,BOSTON,MA 02129. UNIV TEXAS,MD ANDERSON HOSP & TUMOR INST,CTR CANC,DEPT TUMOR BIOL,HOUSTON,TX 77030. HARVARD UNIV,CHILDRENS HOSP,SCH MED,DANA FARBER CANC INST,DEPT PEDIAT,DIV HEMATOL ONCOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV BIOSTAT & EPIDEMIOL,BOSTON,MA 02115. UNIV TEXAS,MD ANDERSON HOSP & TUMOR INST,CTR CANC,DIV PEDIAT,HOUSTON,TX 77030. NCI,DIV CANC ETIOL,CLIN EPIDEMIOL BRANCH,BETHESDA,MD 20892. NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,BETHESDA,MD 20892. FU NCI NIH HHS [5-T32-CA09299]; PHS HHS [34936] NR 41 TC 2651 Z9 2690 U1 4 U2 42 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 30 PY 1990 VL 250 IS 4985 BP 1233 EP 1238 DI 10.1126/science.1978757 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EK723 UT WOS:A1990EK72300030 PM 1978757 ER PT J AU WANG, JH YAN, YW GARRETT, TPJ LIU, JH RODGERS, DW GARLICK, RL TARR, GE HUSAIN, Y REINHERZ, EL HARRISON, SC AF WANG, JH YAN, YW GARRETT, TPJ LIU, JH RODGERS, DW GARLICK, RL TARR, GE HUSAIN, Y REINHERZ, EL HARRISON, SC TI ATOMIC-STRUCTURE OF A FRAGMENT OF HUMAN CD4 CONTAINING 2 IMMUNOGLOBULIN-LIKE DOMAINS SO NATURE LA English DT Article C1 UPJOHN CO,KALAMAZOO,MI 49007. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,IMMUNOL LAB,BOSTON,MA 02115. HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138. RP WANG, JH (reprint author), HARVARD UNIV,DEPT BIOCHEM & MOLEC BIOL,7 DIVIN AVE,CAMBRIDGE,MA 02138, USA. NR 68 TC 542 Z9 547 U1 1 U2 6 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD NOV 29 PY 1990 VL 348 IS 6300 BP 411 EP 418 DI 10.1038/348411a0 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EK697 UT WOS:A1990EK69700052 PM 1701030 ER PT J AU KISTLER, JP AF KISTLER, JP TI THE EFFECT OF LOW-DOSE WARFARIN ON THE RISK OF STROKE IN PATIENTS WITH NONRHEUMATIC ATRIAL-FIBRILLATION SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article RP KISTLER, JP (reprint author), MASSACHUSETTS GEN HOSP,STROKE SERV,BOSTON,MA 02114, USA. NR 23 TC 727 Z9 744 U1 0 U2 12 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 29 PY 1990 VL 323 IS 22 BP 1505 EP 1511 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA EK209 UT WOS:A1990EK20900001 ER PT J AU COOK, JL GELLER, A DEININGER, P AF COOK, JL GELLER, A DEININGER, P TI GENE-TRANSFER INTO GLIAL-CELLS USING HERPES-SIMPLEX VIRUS VECTORS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELL GROWTH REGULAT,BOSTON,MA 02115. LOUISIANA STATE UNIV,MED CTR,DEPT BIOCHEM & MOLEC BIOL,NEW ORLEANS,LA 70112. RP COOK, JL (reprint author), ALTON OCHSNER MED FDN & OCHSNER CLIN,MOLEC GENET LAB,NEW ORLEANS,LA 70121, USA. OI Deininger, Prescott/0000-0002-1067-3028 NR 3 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 28 PY 1990 VL 605 BP 346 EP 349 DI 10.1111/j.1749-6632.1990.tb42408.x PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EZ862 UT WOS:A1990EZ86200033 ER PT J AU SOBEL, RA TUOHY, VK LU, ZJ LAURSEN, RA LEES, MB AF SOBEL, RA TUOHY, VK LU, ZJ LAURSEN, RA LEES, MB TI ACUTE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN SJL J MICE INDUCED BY A SYNTHETIC PEPTIDE OF MYELIN PROTEOLIPID PROTEIN SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID APOPROTEIN C1 EK SHRIVER CTR,WALTHAM,MA 02254. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115. BOSTON UNIV,DEPT CHEM,BOSTON,MA 02215. RP SOBEL, RA (reprint author), MASSACHUSETTS GEN HOSP,IMMUNOPATHOL UNIT,COX 5,FRUIT ST,BOSTON,MA 02114, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD NOV 28 PY 1990 VL 605 BP 453 EP 455 DI 10.1111/j.1749-6632.1990.tb42444.x PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EZ862 UT WOS:A1990EZ86200070 ER PT J AU ZWERLING, C RYAN, J ORAV, EJ AF ZWERLING, C RYAN, J ORAV, EJ TI THE EFFICACY OF PREEMPLOYMENT DRUG SCREENING FOR MARIJUANA AND COCAINE IN PREDICTING EMPLOYMENT OUTCOME SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article C1 TUFTS UNIV,SCH MED,DEPT COMMUNITY MED,BOSTON,MA 02111. HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT,BOSTON,MA 02115. BOSTON POSTAL SERV,MED UNIT,BOSTON,MA. HARVARD UNIV,SCH PUBL HLTH,DEPT ENVIRONM SCI & PHYSIOL,OCCUPAT MED PROGRAM,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,OCCUPAT MED CLIN,BOSTON,MA 02114. NR 19 TC 88 Z9 88 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 28 PY 1990 VL 264 IS 20 BP 2639 EP 2643 DI 10.1001/jama.264.20.2639 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EJ584 UT WOS:A1990EJ58400026 PM 2232039 ER PT J AU TEJANIBUTT, SM BRUNSWICK, DJ FRAZER, A AF TEJANIBUTT, SM BRUNSWICK, DJ FRAZER, A TI [H-3] NISOXETINE - A NEW RADIOLIGAND FOR NOREPINEPHRINE UPTAKE SITES IN BRAIN SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Note C1 UNIV PENN,SCH MED,DEPT PSYCHIAT,PHILADELPHIA,PA 19104. UNIV PENN,SCH MED,NEUROPSYCHOPHARMACOL UNIT,PHILADELPHIA,PA 19104. RP TEJANIBUTT, SM (reprint author), VET AFFAIRS MED CTR,NEUROPSYCHOPHARMACOL UNIT 151E,UNIV & WOODLAND AVE,PHILADELPHIA,PA 19104, USA. FU NIDA NIH HHS [DA 05137] NR 10 TC 109 Z9 109 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD NOV 27 PY 1990 VL 191 IS 2 BP 239 EP 243 DI 10.1016/0014-2999(90)94155-Q PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EM858 UT WOS:A1990EM85800017 PM 2086242 ER PT J AU PEETERMANS, JA JANMEY, PA NISHIO, I ZANER, KS TANAKA, T AF PEETERMANS, JA JANMEY, PA NISHIO, I ZANER, KS TANAKA, T TI EFFECT OF LASER ILLUMINATION ON ACTIN POLYMERIZATION AND ASSEMBLY - SIMULTANEOUS MEASUREMENTS USING STATIC AND DYNAMIC LASER-LIGHT SCATTERING, FLUORESCENCE, AND VISCOMETRY SO MACROMOLECULES LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,HEMATOL ONCOL UNIT,BOSTON,MA 02114. MIT,CTR MAT SCI & ENGN,CAMBRIDGE,MA 02139. RP PEETERMANS, JA (reprint author), MIT,DEPT PHYS,CAMBRIDGE,MA 02139, USA. NR 22 TC 2 Z9 2 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD NOV 26 PY 1990 VL 23 IS 24 BP 5083 EP 5087 DI 10.1021/ma00226a008 PG 5 WC Polymer Science SC Polymer Science GA EK429 UT WOS:A1990EK42900008 ER PT J AU HALLEK, M AF HALLEK, M TI CHRONOBIOLOGY IN PEDIATRICS SO MUNCHENER MEDIZINISCHE WOCHENSCHRIFT LA German DT Editorial Material RP HALLEK, M (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,44 BINNEY ST,BOSTON,MA 02115, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MMW MEDIZIN VERLAG GMBH PI MUNICH 80 PA NEUMARKTER STRASSE 18, W-8000 MUNICH 80, GERMANY SN 0341-3098 J9 MUNCHEN MED WOCHEN JI Munch. Med. Wochenschr. PD NOV 23 PY 1990 VL 132 IS 47 BP 753 EP 756 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA EL183 UT WOS:A1990EL18300011 ER PT J AU WALZ, G ARUFFO, A KOLANUS, W BEVILACQUA, M SEED, B AF WALZ, G ARUFFO, A KOLANUS, W BEVILACQUA, M SEED, B TI RECOGNITION BY ELAM-1 OF THE SIALYL-LEX DETERMINANT ON MYELOID AND TUMOR-CELLS SO SCIENCE LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115. RP WALZ, G (reprint author), HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115, USA. FU NHLBI NIH HHS [HL36028]; NIAID NIH HHS [AI27849]; NIDDK NIH HHS [DK43031] NR 43 TC 848 Z9 854 U1 1 U2 3 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 23 PY 1990 VL 250 IS 4984 BP 1132 EP 1135 DI 10.1126/science.1701275 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EJ581 UT WOS:A1990EJ58100035 PM 1701275 ER PT J AU GOLD, HK AF GOLD, HK TI CONJUNCTIVE ANTITHROMBOTIC AND THROMBOLYTIC THERAPY FOR CORONARY-ARTERY OCCLUSION SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material RP GOLD, HK (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. NR 12 TC 44 Z9 44 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 22 PY 1990 VL 323 IS 21 BP 1483 EP 1485 DI 10.1056/NEJM199011223232110 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA EJ407 UT WOS:A1990EJ40700010 PM 2233922 ER PT J AU HUA, QX WEISS, MA AF HUA, QX WEISS, MA TI TOWARD THE SOLUTION STRUCTURE OF HUMAN INSULIN - SEQUENTIAL 2D H-1-NMR ASSIGNMENT OF A DES-PENTAPEPTIDE ANALOG AND COMPARISON WITH CRYSTAL-STRUCTURE SO BIOCHEMISTRY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. MIT,FRANCIS BITTER NATL MAGNET LAB,CAMBRIDGE,MA 02139. MASSACHUSETTS GEN HOSP,DEPT MED,BOSTON,MA 02114. FU NCRR NIH HHS [1 S10 RR04862-01, RR-00995] NR 50 TC 42 Z9 43 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD NOV 20 PY 1990 VL 29 IS 46 BP 10545 EP 10555 DI 10.1021/bi00498a018 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ593 UT WOS:A1990EJ59300018 PM 2271664 ER PT J AU ORKIN, SH AF ORKIN, SH TI GLOBIN GENE-REGULATION AND SWITCHING - CIRCA 1990 SO CELL LA English DT Review C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,HOWARD HUGHES MED INST,DEPT PEDIAT,BOSTON,MA 02115. RP ORKIN, SH (reprint author), HARVARD UNIV,CHILDRENS HOSP,SCH MED,DIV HEMATOL ONCOL,BOSTON,MA 02115, USA. NR 10 TC 436 Z9 436 U1 1 U2 8 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD NOV 16 PY 1990 VL 63 IS 4 BP 665 EP 672 DI 10.1016/0092-8674(90)90133-Y PG 8 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EJ590 UT WOS:A1990EJ59000003 PM 2225071 ER PT J AU FEHMANN, HC GOKE, B AF FEHMANN, HC GOKE, B TI AMYLIN, ISLET AMYLOID AND TYPE-II DIABETES-MELLITUS SO DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT LA German DT Note C1 UNIV MICHIGAN,DEPT PHYSIOL,ANN ARBOR,MI 48109. RP FEHMANN, HC (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,MOLEC ENDOCRINOL LAB,BOSTON,MA 02114, USA. NR 47 TC 1 Z9 1 U1 0 U2 0 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0012-0472 J9 DEUT MED WOCHENSCHR JI Dtsch. Med. Wochenschr. PD NOV 16 PY 1990 VL 115 IS 46 BP 1769 EP 1772 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA EJ436 UT WOS:A1990EJ43600007 PM 2226190 ER PT J AU DEGASPERI, R THOMAS, LJ SUGIYAMA, E CHANG, HM BECK, PJ ORLEAN, P ALBRIGHT, C WANECK, G SAMBROOK, JF WARREN, CD YEH, ETH AF DEGASPERI, R THOMAS, LJ SUGIYAMA, E CHANG, HM BECK, PJ ORLEAN, P ALBRIGHT, C WANECK, G SAMBROOK, JF WARREN, CD YEH, ETH TI CORRECTION OF A DEFECT IN MAMMALIAN GPI ANCHOR BIOSYNTHESIS BY A TRANSFECTED YEAST GENE SO SCIENCE LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,ARTHRIT UNIT,BOSTON,MA 02114. UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT ANESTHESIA,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT SURG,BOSTON,MA 02114. MIT,CTR CANC RES,CAMBRIDGE,MA 02139. FU NIAMS NIH HHS [AR-03564]; NICHD NIH HHS [HD-16942, HD-21087] NR 32 TC 87 Z9 87 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 16 PY 1990 VL 250 IS 4983 BP 988 EP 991 DI 10.1126/science.1978413 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH793 UT WOS:A1990EH79300043 PM 1978413 ER PT J AU FONTAINE, B KHURANA, TS HOFFMAN, EP BRUNS, GAP HAINES, JL TROFATTER, JA HANSON, MP RICH, J MCFARLANE, H YASEK, DM ROMANO, D GUSELLA, JF BROWN, RH AF FONTAINE, B KHURANA, TS HOFFMAN, EP BRUNS, GAP HAINES, JL TROFATTER, JA HANSON, MP RICH, J MCFARLANE, H YASEK, DM ROMANO, D GUSELLA, JF BROWN, RH TI HYPERKALEMIC PERIODIC PARALYSIS AND THE ADULT MUSCLE SODIUM-CHANNEL ALPHA-SUBUNIT GENE SO SCIENCE LA English DT Article C1 MASSACHUSETTS GEN HOSP,DAY NEUROMUSCULAR RES LAB,BOSTON,MA 02129. HARVARD UNIV,SCH MED,PROGRAM NEUROSCI,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,DIV MED GENET,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,DEPT PEDIAT,BOSTON,MA 02115. RP FONTAINE, B (reprint author), MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET LAB,BOSTON,MA 02129, USA. RI Haines, Jonathan/C-3374-2012 FU NINDS NIH HHS [NS-22224, NS-24279] NR 26 TC 270 Z9 270 U1 2 U2 9 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 16 PY 1990 VL 250 IS 4983 BP 1000 EP 1002 DI 10.1126/science.2173143 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH793 UT WOS:A1990EH79300047 PM 2173143 ER PT J AU TILKEMEIER, PL GUINEY, TE LARAIA, PJ BOUCHER, CA AF TILKEMEIER, PL GUINEY, TE LARAIA, PJ BOUCHER, CA TI PROGNOSTIC VALUE OF PREDISCHARGE LOW-LEVEL EXERCISE THALLIUM TESTING AFTER THROMBOLYTIC TREATMENT OF ACUTE MYOCARDIAL-INFARCTION SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article C1 MASSACHUSETTS GEN HOSP,CARDIAC UNIT,BOSTON,MA 02114. SPAULDING REHABIL HOSP,BOSTON,MA 02114. NR 13 TC 48 Z9 48 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD NOV 15 PY 1990 VL 66 IS 17 BP 1203 EP 1207 DI 10.1016/0002-9149(90)91100-K PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EH711 UT WOS:A1990EH71100011 PM 2239723 ER PT J AU MARCUS, DM MINKOVITZ, JB WARDWELL, SD ALBERT, DM AF MARCUS, DM MINKOVITZ, JB WARDWELL, SD ALBERT, DM TI THE VALUE OF NUCLEOLAR ORGANIZER REGIONS IN UVEAL MELANOMA SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,DAVID G COGAN EYE PATHOL LAB,243 CHARLES ST,BOSTON,MA 02114. FU NEI NIH HHS [EY01917-15] NR 25 TC 23 Z9 23 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD NOV 15 PY 1990 VL 110 IS 5 BP 527 EP 534 PG 8 WC Ophthalmology SC Ophthalmology GA EG045 UT WOS:A1990EG04500008 PM 1700611 ER PT J AU RAGO, R MITCHEN, J WILDING, G AF RAGO, R MITCHEN, J WILDING, G TI DNA FLUOROMETRIC ASSAY IN 96-WELL TISSUE-CULTURE PLATES USING HOECHST-33258 AFTER CELL-LYSIS BY FREEZING IN DISTILLED WATER SO ANALYTICAL BIOCHEMISTRY LA English DT Article C1 UNIV WISCONSIN,CTR CLIN CANC,DEPT HUMAN ONCOL,K4-666 CSC 600 HIGHLAND AVE,MADISON,WI 53792. WILLIAM S MIDDLETON MEM VET ADM MED CTR,MADISON,WI 53705. FU NCI NIH HHS [R29-CA50590, T321-CA 09614] NR 4 TC 340 Z9 341 U1 1 U2 18 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD NOV 15 PY 1990 VL 191 IS 1 BP 31 EP 34 PG 4 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA EK227 UT WOS:A1990EK22700006 PM 1706565 ER PT J AU FREESE, A GELLER, AI NEVE, R AF FREESE, A GELLER, AI NEVE, R TI HSV-1 VECTOR MEDIATED NEURONAL GENE DELIVERY - STRATEGIES FOR MOLECULAR NEUROSCIENCE AND NEUROLOGY SO BIOCHEMICAL PHARMACOLOGY LA English DT Editorial Material C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELL GROWTH & REGULAT,BOSTON,MA 02115. UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717. RP FREESE, A (reprint author), MIT,DIV HLTH SCI,CAMBRIDGE,MA 02139, USA. RI Geller, Alfred/C-6469-2012 NR 87 TC 35 Z9 35 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD NOV 15 PY 1990 VL 40 IS 10 BP 2189 EP 2199 DI 10.1016/0006-2952(90)90711-S PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EK055 UT WOS:A1990EK05500001 PM 2173924 ER PT J AU BIERER, BE NATHAN, DG AF BIERER, BE NATHAN, DG TI THE EFFECT OF DESFERRITHIOCIN, AN ORAL IRON CHELATOR, ON T-CELL FUNCTION SO BLOOD LA English DT Article C1 BRIGHAM & WOMENS HOSP,DEPT MED,DIV HEMATOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED & PEDIAT,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,DEPT HEMATOL ONCOL,BOSTON,MA 02115. RP BIERER, BE (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PEDIAT ONCOL,DIV PEDIAT ONCOL,ROOM 1610B,BOSTON,MA 02115, USA. FU NCI NIH HHS [P01-CA39542-05] NR 36 TC 20 Z9 20 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1990 VL 76 IS 10 BP 2052 EP 2059 PG 8 WC Hematology SC Hematology GA EJ391 UT WOS:A1990EJ39100022 PM 2242426 ER PT J AU BARUT, BA COCHRAN, MK OHARA, C ANDERSON, KC AF BARUT, BA COCHRAN, MK OHARA, C ANDERSON, KC TI RESPONSE PATTERNS OF HAIRY-CELL LEUKEMIA TO B-CELL MITOGENS AND GROWTH-FACTORS SO BLOOD LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. NEW ENGLAND DEACONESS HOSP,DEPT PATHOL,BOSTON,MA 02215. RP BARUT, BA (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,44 BINNEY ST,BOSTON,MA 02115, USA. NR 36 TC 20 Z9 20 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1990 VL 76 IS 10 BP 2091 EP 2097 PG 7 WC Hematology SC Hematology GA EJ391 UT WOS:A1990EJ39100028 PM 2242429 ER PT J AU GUPTA, SK NILES, JL MCCLUSKEY, RT ARNAOUT, MA AF GUPTA, SK NILES, JL MCCLUSKEY, RT ARNAOUT, MA TI IDENTITY OF WEGENER AUTOANTIGEN (P-29) WITH PROTEINASE-3 AND MYELOBLASTIN SO BLOOD LA English DT Letter RP GUPTA, SK (reprint author), MASSACHUSETTS GEN HOSP,DEPT MED,RENAL UNIT,BOSTON,MA 02114, USA. NR 8 TC 33 Z9 34 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1990 VL 76 IS 10 BP 2162 EP 2162 PG 1 WC Hematology SC Hematology GA EJ391 UT WOS:A1990EJ39100038 PM 2242436 ER PT J AU SPRIGGS, DR SHERMAN, ML IMAMURA, K MOHRI, M RODRIGUEZ, C ROBBINS, G KUFE, DW AF SPRIGGS, DR SHERMAN, ML IMAMURA, K MOHRI, M RODRIGUEZ, C ROBBINS, G KUFE, DW TI PHOSPHOLIPASE-A2 ACTIVATION AND AUTOINDUCTION OF TUMOR-NECROSIS-FACTOR GENE-EXPRESSION BY TUMOR-NECROSIS-FACTOR SO CANCER RESEARCH LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,CLIN PHARMACOL LAB,BOSTON,MA 02115. RI Robbins, Gregory/F-7988-2011 FU NCI NIH HHS [CA-47722, CA-42802] NR 50 TC 70 Z9 70 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7101 EP 7107 PG 7 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600002 PM 2121330 ER PT J AU BAND, V ZAJCHOWSKI, D SWISSHELM, K TRASK, D KULESA, V COHEN, C CONNOLLY, J SAGER, R AF BAND, V ZAJCHOWSKI, D SWISSHELM, K TRASK, D KULESA, V COHEN, C CONNOLLY, J SAGER, R TI TUMOR PROGRESSION IN 4 MAMMARY EPITHELIAL-CELL LINES DERIVED FROM THE SAME PATIENT SO CANCER RESEARCH LA English DT Article C1 BETH ISRAEL HOSP,DEPT PATHOL,BOSTON,MA 02115. LOUISIANA STATE UNIV,MED CTR,DEPT MED,NEW ORLEANS,LA 70112. RP BAND, V (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CANC GENET,BOSTON,MA 02115, USA. FU NCI NIH HHS [CA39814] NR 29 TC 149 Z9 149 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 15 PY 1990 VL 50 IS 22 BP 7351 EP 7357 PG 7 WC Oncology SC Oncology GA EH006 UT WOS:A1990EH00600042 PM 1977518 ER PT J AU CARPENTER, CL DUCKWORTH, BC AUGER, KR COHEN, B SCHAFFHAUSEN, BS CANTLEY, LC AF CARPENTER, CL DUCKWORTH, BC AUGER, KR COHEN, B SCHAFFHAUSEN, BS CANTLEY, LC TI PURIFICATION AND CHARACTERIZATION OF PHOSPHOINOSITIDE 3-KINASE FROM RAT-LIVER SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 TUFTS UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02111. MASSACHUSETTS GEN HOSP,HEMATOL ONCOL UNIT,BOSTON,MA 02114. RP CARPENTER, CL (reprint author), TUFTS UNIV,SCH MED,DEPT PHYSIOL,136 HARRISON AVE,BOSTON,MA 02111, USA. RI Cantley, Lewis/D-1800-2014 OI Cantley, Lewis/0000-0002-1298-7653 FU NCI NIH HHS [CA 34722]; NIDDK NIH HHS [DK 34928]; NIGMS NIH HHS [GM 36624, R01 GM041890] NR 35 TC 522 Z9 525 U1 0 U2 6 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19704 EP 19711 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800053 PM 2174051 ER PT J AU CHANG, YH TEICHERT, U SMITH, JA AF CHANG, YH TEICHERT, U SMITH, JA TI PURIFICATION AND CHARACTERIZATION OF A METHIONINE AMINOPEPTIDASE FROM SACCHAROMYCES-CEREVISIAE SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02114. RP CHANG, YH (reprint author), MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114, USA. NR 30 TC 79 Z9 79 U1 1 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 1990 VL 265 IS 32 BP 19892 EP 19897 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ188 UT WOS:A1990EJ18800080 PM 2246265 ER PT J AU ROBERTSON, MJ CALIGIURI, MA MANLEY, TJ LEVINE, H RITZ, J AF ROBERTSON, MJ CALIGIURI, MA MANLEY, TJ LEVINE, H RITZ, J TI HUMAN NATURAL-KILLER-CELL ADHESION MOLECULES - DIFFERENTIAL EXPRESSION AFTER ACTIVATION AND PARTICIPATION IN CYTOLYSIS SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. RP ROBERTSON, MJ (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,44 BINNEY ST,BOSTON,MA 02115, USA. RI Ritz, Jerome/C-7929-2009 OI Ritz, Jerome/0000-0001-5526-4669 FU NCI NIH HHS [CA-41619] NR 45 TC 253 Z9 255 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3194 EP 3201 PG 8 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900007 PM 1700001 ER PT J AU REMOLDODONNELL, E ROSEN, FS AF REMOLDODONNELL, E ROSEN, FS TI PROTEOLYTIC FRAGMENTATION OF SIALOPHORIN (CD43) - LOCALIZATION OF THE ACTIVATION-INDUCING SITE AND EXAMINATION OF THE ROLE OF SIALIC-ACID SO JOURNAL OF IMMUNOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115. CHILDRENS HOSP MED CTR,DIV IMMUNOL,BOSTON,MA 02115. RP REMOLDODONNELL, E (reprint author), HARVARD UNIV,CTR BLOOD RES,800 HUNTINGTON AVE,BOSTON,MA 02115, USA. FU NIAID NIH HHS [AI21163]; NIGMS NIH HHS [GM37298] NR 32 TC 36 Z9 36 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1990 VL 145 IS 10 BP 3372 EP 3378 PG 7 WC Immunology SC Immunology GA EG889 UT WOS:A1990EG88900032 PM 2230123 ER PT J AU SIBER, GR SANTOSHAM, M REID, GR THOMPSON, C ALMEIDOHILL, J MORELL, A DELANGE, G KETCHAM, JK CALLAHAN, EH AF SIBER, GR SANTOSHAM, M REID, GR THOMPSON, C ALMEIDOHILL, J MORELL, A DELANGE, G KETCHAM, JK CALLAHAN, EH TI IMPAIRED ANTIBODY-RESPONSE TO HAEMOPHILUS-INFLUENZAE TYPE-B POLYSACCHARIDE AND LOW IGG2 AND IGG4 CONCENTRATIONS IN APACHE CHILDREN SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article C1 MASSACHUSETTS PUBL HLTH BIOL LABS,BOSTON,MA. JOHNS HOPKINS UNIV,DEPT INT HLTH,DIV GEOG MED,BALTIMORE,MD 21218. NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,AMSTERDAM,NETHERLANDS. US PHS,INDIAN HOSP,WHITERIVER,AZ. SWISS RED CROSS,BLOOD TRANSFUS SERV,BERN,SWITZERLAND. RP SIBER, GR (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,INFECT DIS LAB,44 BINNEY ST,BOSTON,MA 02115, USA. FU NIAID NIH HHS [AI18125, AI20738, AI24996] NR 46 TC 94 Z9 95 U1 1 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 15 PY 1990 VL 323 IS 20 BP 1387 EP 1392 DI 10.1056/NEJM199011153232005 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA EH546 UT WOS:A1990EH54600005 PM 2233905 ER PT J AU ROSS, NS ARON, DC AF ROSS, NS ARON, DC TI HORMONAL EVALUATION OF THE PATIENT WITH AN INCIDENTALLY DISCOVERED ADRENAL MASS SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Review C1 UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA 90024. VET AFFAIRS MED CTR,ENDOCRINOL SECT,CLEVELAND,OH. CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED,DIV ENDOCRINOL & HYPERTENS,CLEVELAND,OH 44106. RP ROSS, NS (reprint author), W LOS ANGELES VET AFFAIRS MED CTR,ENDOCRINOL SECT,W111D,SAWTELLE & WILSHIRE BLVD,LOS ANGELES,CA 90073, USA. FU NICHD NIH HHS [HD25299]; NIDDK NIH HHS [DK41527] NR 38 TC 255 Z9 258 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 15 PY 1990 VL 323 IS 20 BP 1401 EP 1405 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EH546 UT WOS:A1990EH54600007 PM 2233907 ER PT J AU LEAF, A RYAN, TJ AF LEAF, A RYAN, TJ TI PREVENTION OF CORONARY-ARTERY DISEASE - A MEDICAL IMPERATIVE SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material C1 BOSTON UNIV,MED CTR,BOSTON,MA 02215. RP LEAF, A (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. NR 22 TC 13 Z9 13 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 15 PY 1990 VL 323 IS 20 BP 1416 EP 1419 DI 10.1056/NEJM199011153232011 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA EH546 UT WOS:A1990EH54600011 PM 2233911 ER PT J AU BECKER, PS SCHWARTZ, MA MORROW, JS LUX, SE AF BECKER, PS SCHWARTZ, MA MORROW, JS LUX, SE TI RADIOLABEL-TRANSFER CROSS-LINKING DEMONSTRATES THAT PROTEIN-4.1 BINDS TO THE N-TERMINAL REGION OF BETA-SPECTRIN AND TO ACTIN IN BINARY INTERACTIONS SO EUROPEAN JOURNAL OF BIOCHEMISTRY LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT CELLULAR & MOLEC PHYSIOL,BOSTON,MA 02115. YALE UNIV,SCH MED,DEPT PATHOL,NEW HAVEN,CT 06510. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. HARVARD UNIV,CHILDRENS HOSP,SCH MED,DIV HEMATOL ONCOL,BOSTON,MA 02115. RP BECKER, PS (reprint author), YALE UNIV,SCH MED,DEPT INTERNAL MED,HEMATOL SECT,333 CEDAR ST,NEW HAVEN,CT 06510, USA. FU NHLBI NIH HHS [5 T32 HL07262]; NIDDK NIH HHS [DK34083]; NIGMS NIH HHS [2T 32 GM07753-06, T32 GM007753] NR 68 TC 38 Z9 38 U1 1 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0014-2956 J9 EUR J BIOCHEM JI Eur. J. Biochem. PD NOV 13 PY 1990 VL 193 IS 3 BP 827 EP 836 DI 10.1111/j.1432-1033.1990.tb19406.x PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EJ270 UT WOS:A1990EJ27000027 PM 2249696 ER PT J AU HUANG, P TEMIZER, D QUERTERMOUS, T AF HUANG, P TEMIZER, D QUERTERMOUS, T TI POLYMERASE CHAIN-REACTION CLONING OF L-TYPE CALCIUM-CHANNEL SEQUENCES FROM THE HEART AND THE BRAIN SO FEBS LETTERS LA English DT Article RP HUANG, P (reprint author), MASSACHUSETTS GEN HOSP,DEPT MED,CARDIAC UNIT,FRUIT ST,BOSTON,MA 02114, USA. FU NHLBI NIH HHS [T32HL07208-14] NR 20 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-5793 J9 FEBS LETT JI FEBS Lett. PD NOV 12 PY 1990 VL 274 IS 1-2 BP 207 EP 213 DI 10.1016/0014-5793(90)81365-U PG 7 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA EK676 UT WOS:A1990EK67600051 PM 1701401 ER PT J AU FURUKAWA, Y PIWNICAWORMS, H ERNST, TJ KANAKURA, Y GRIFFIN, JD AF FURUKAWA, Y PIWNICAWORMS, H ERNST, TJ KANAKURA, Y GRIFFIN, JD TI CDC2 GENE-EXPRESSION AT THE G1-TRANSITION TO S-TRANSITION IN HUMAN LYMPHOCYTES-T SO SCIENCE LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115. TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111. RI Piwnica-Worms, Helen/C-5214-2012 FU NCI NIH HHS [CA36167, CA47843, CA50767] NR 48 TC 247 Z9 252 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 9 PY 1990 VL 250 IS 4982 BP 805 EP 808 DI 10.1126/science.2237430 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EG883 UT WOS:A1990EG88300035 PM 2237430 ER PT J AU DRYJA, TP MCGEE, TL HAHN, LB COWLEY, GS OLSSON, JE REICHEL, E SANDBERG, MA BERSON, EL AF DRYJA, TP MCGEE, TL HAHN, LB COWLEY, GS OLSSON, JE REICHEL, E SANDBERG, MA BERSON, EL TI MUTATIONS WITHIN THE RHODOPSIN GENE IN PATIENTS WITH AUTOSOMAL DOMINANT RETINITIS-PIGMENTOSA SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,HOWE LAB OPHTHALMOL,BOSTON,MA 02114. RP DRYJA, TP (reprint author), HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,DEPT OPHTHALMOL,BOSTON,MA 02114, USA. FU NEI NIH HHS [EY-00169, EY-02014, EY-08683] NR 20 TC 271 Z9 283 U1 1 U2 7 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 8 PY 1990 VL 323 IS 19 BP 1302 EP 1307 DI 10.1056/NEJM199011083231903 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA EG588 UT WOS:A1990EG58800003 PM 2215617 ER PT J AU NUSSBAUM, SR GAZ, RD ARNOLD, A AF NUSSBAUM, SR GAZ, RD ARNOLD, A TI HYPERCALCEMIA AND ECTOPIC SECRETION OF PARATHYROID-HORMONE BY AN OVARIAN-CARCINOMA WITH REARRANGEMENT OF THE GENE FOR PARATHYROID-HORMONE SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Note C1 MASSACHUSETTS GEN HOSP,ENDOCRINE UNIT,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,SURG SERV,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 30 TC 98 Z9 98 U1 0 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 8 PY 1990 VL 323 IS 19 BP 1324 EP 1328 DI 10.1056/NEJM199011083231907 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EG588 UT WOS:A1990EG58800007 PM 2215618 ER PT J AU BYAR, DP SCHOENFELD, DA GREEN, SB AMATO, DA DAVIS, R DEGRUTTOLA, V FINKELSTEIN, DM GATSONIS, C GELBER, RD LAGAKOS, S LEFKOPOULOU, M TSIATIS, AA ZELEN, M PETO, J FREEDMAN, LS GAIL, M SIMON, R ELLENBERG, SS ANDERSON, JR COLLINS, R PETO, R PETO, T AF BYAR, DP SCHOENFELD, DA GREEN, SB AMATO, DA DAVIS, R DEGRUTTOLA, V FINKELSTEIN, DM GATSONIS, C GELBER, RD LAGAKOS, S LEFKOPOULOU, M TSIATIS, AA ZELEN, M PETO, J FREEDMAN, LS GAIL, M SIMON, R ELLENBERG, SS ANDERSON, JR COLLINS, R PETO, R PETO, T TI DESIGN CONSIDERATIONS FOR AIDS TRIALS SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115. INST CANC RES,SUTTON SM2 5PX,SURREY,ENGLAND. INST CANC RES,LONDON SM2 5PX,ENGLAND. UNIV NEBRASKA,MED CTR,OMAHA,NE 68105. UNIV OXFORD,OXFORD OX2 6HE,ENGLAND. RP BYAR, DP (reprint author), NCI,BETHESDA,MD 20892, USA. FU NIAID NIH HHS [N01-AI-95030] NR 27 TC 101 Z9 101 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 8 PY 1990 VL 323 IS 19 BP 1343 EP 1348 DI 10.1056/NEJM199011083231912 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA EG588 UT WOS:A1990EG58800012 PM 2215622 ER PT J AU SHIH, VE TENANBAUM, A AF SHIH, VE TENANBAUM, A TI AMINOACIDURIA DUE TO VINYL-GABA ADMINISTRATION SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 EUNICE KENNEDY SHRIVER CTR MENTAL RETARDAT INC,WALTHAM,MA 02154. RP SHIH, VE (reprint author), MASSACHUSETTS GEN HOSP,BOSTON,MA 02114, USA. NR 2 TC 2 Z9 2 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 8 PY 1990 VL 323 IS 19 BP 1353 EP 1353 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EG588 UT WOS:A1990EG58800024 PM 2215628 ER PT J AU HEFETZ, Y DUNN, DA DEUTSCH, TF BUCKLEY, L HILLENKAMP, F KOCHEVAR, IE AF HEFETZ, Y DUNN, DA DEUTSCH, TF BUCKLEY, L HILLENKAMP, F KOCHEVAR, IE TI LASER PHOTOCHEMISTRY OF DNA - 2-PHOTON ABSORPTION AND OPTICAL-BREAKDOWN USING HIGH-INTENSITY, 532-NM RADIATION SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT DERMATOL,WELLMAN LABS,BOSTON,MA 02114. UNIV MUNSTER,INST MED PHYS,W-4400 MUNSTER,GERMANY. NR 42 TC 17 Z9 17 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD NOV 7 PY 1990 VL 112 IS 23 BP 8528 EP 8532 DI 10.1021/ja00179a043 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA EG466 UT WOS:A1990EG46600043 ER PT J AU IM, MJ GRAHAM, RM AF IM, MJ GRAHAM, RM TI A NOVEL GUANINE NUCLEOTIDE-BINDING PROTEIN COUPLED TO THE ALPHA-1-ADRENERGIC RECEPTOR .1. IDENTIFICATION BY PHOTOLABELING OF MEMBRANE AND TERNARY COMPLEX PREPARATIONS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 MASSACHUSETTS GEN HOSP,CARDIAC UNIT,CELLULAR & MOLEC RES LAB,BOSTON,MA 02114. HARVARD UNIV,CAMBRIDGE,MA 02138. FU NHLBI NIH HHS [HL-33107]; NINDS NIH HHS [NS-19583] NR 50 TC 101 Z9 101 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 18944 EP 18951 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900043 PM 2172239 ER PT J AU IM, MJ RIEK, RP GRAHAM, RM AF IM, MJ RIEK, RP GRAHAM, RM TI A NOVEL GUANINE NUCLEOTIDE-BINDING PROTEIN COUPLED TO THE ALPHA-1-ADRENERGIC RECEPTOR .2. PURIFICATION, CHARACTERIZATION, AND RECONSTITUTION SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 MASSACHUSETTS GEN HOSP,CARDIAC UNIT,CELLULAR & MOLEC RES LAB,BOSTON,MA 02114. HARVARD UNIV,CAMBRIDGE,MA 02138. FU NHLBI NIH HHS [HL-33107]; NINDS NIH HHS [NS-19583] NR 44 TC 82 Z9 82 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 18952 EP 18960 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900044 PM 2172240 ER PT J AU RAM, PA WAXMAN, DJ AF RAM, PA WAXMAN, DJ TI PRETRANSLATIONAL CONTROL BY THYROID-HORMONE OF RAT-LIVER STEROID 5-ALPHA-REDUCTASE AND COMPARISON TO THE THYROID DEPENDENCE OF 2 GROWTH HORMONE-REGULATED CYP2C MESSENGER-RNAS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,JF-525,44 BINNEY ST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. FU NIDDK NIH HHS [R01 DK033765] NR 46 TC 64 Z9 64 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 5 PY 1990 VL 265 IS 31 BP 19223 EP 19229 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EF739 UT WOS:A1990EF73900083 PM 2172247 ER PT J AU SWEADNER, KJ AF SWEADNER, KJ TI ANOMALIES IN THE ELECTROPHORETIC RESOLUTION OF NA+/K+-ATPASE CATALYTIC SUBUNIT ISOFORMS REVEAL UNUSUAL PROTEIN DETERGENT INTERACTIONS SO BIOCHIMICA ET BIOPHYSICA ACTA LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT CELLULAR & MOLEC PHYSIOL,BOSTON,MA 02115. RP SWEADNER, KJ (reprint author), MASSACHUSETTS GEN HOSP,FRUIT ST,BOSTON,MA 02114, USA. FU NHLBI NIH HHS [HL 36271]; NINDS NIH HHS [NS 27653] NR 44 TC 30 Z9 30 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-3002 J9 BIOCHIM BIOPHYS ACTA PD NOV 2 PY 1990 VL 1029 IS 1 BP 13 EP 23 DI 10.1016/0005-2736(90)90431-M PG 11 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EG601 UT WOS:A1990EG60100002 PM 2171651 ER PT J AU LARSEN, E PALABRICA, T SAJER, S GILBERT, GE WAGNER, DD FURIE, BC FURIE, B AF LARSEN, E PALABRICA, T SAJER, S GILBERT, GE WAGNER, DD FURIE, BC FURIE, B TI PADGEM-DEPENDENT ADHESION OF PLATELETS TO MONOCYTES AND NEUTROPHILS IS MEDIATED BY A LINEAGE-SPECIFIC CARBOHYDRATE, LNF-III (CD15) SO CELL LA English DT Article C1 TUFTS UNIV,SCH MED,CTR HEMOSTASIS & THROMBOSIS RES,DIV HEMATOL ONCOL,BOSTON,MA 02111. TUFTS UNIV,NEW ENGLAND MED CTR,SCH MED,DIV CARDIOL,BOSTON,MA 02111. TUFTS UNIV,SCH MED,DEPT MED,BOSTON,MA 02111. TUFTS UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02111. HARVARD UNIV,CHILDRENS HOSP,SCH MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PEDIAT,BOSTON,MA 02115. FU NHLBI NIH HHS [HL42443, HL07574, HL07437] NR 40 TC 333 Z9 335 U1 1 U2 5 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD NOV 2 PY 1990 VL 63 IS 3 BP 467 EP 474 DI 10.1016/0092-8674(90)90443-I PG 8 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA EG687 UT WOS:A1990EG68700005 PM 1699666 ER PT J AU BLEICHER, PA BALK, SP HAGEN, SJ BLUMBERG, RS FLOTTE, TJ TERHORST, C AF BLEICHER, PA BALK, SP HAGEN, SJ BLUMBERG, RS FLOTTE, TJ TERHORST, C TI EXPRESSION OF MURINE CD1 ON GASTROINTESTINAL EPITHELIUM SO SCIENCE LA English DT Article C1 MASSACHUSETTS GEN HOSP,CUTANEOUS BIOL RES CTR,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,MOLEC IMMUNOL LAB,BOSTON,MA 02115. BETH ISRAEL HOSP,DEPT HEMATOL & ONCOL,BOSTON,MA 02215. BRIGHAM & WOMENS HOSP,DEPT GASTROENTEROL,BOSTON,MA 02115. RP BLEICHER, PA (reprint author), MASSACHUSETTS GEN HOSP,DEPT DERMATOL,WELLMAN LABS,BOSTON,MA 02114, USA. FU NCI NIH HHS [CA 01310]; NIAMS NIH HHS [AR 01805] NR 42 TC 214 Z9 215 U1 1 U2 1 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD NOV 2 PY 1990 VL 250 IS 4981 BP 679 EP 682 DI 10.1126/science.1700477 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EF904 UT WOS:A1990EF90400037 PM 1700477 ER PT J AU SHERMAN, ME MAGRO, C BERRY, Y SZYFELBEIN, WM AF SHERMAN, ME MAGRO, C BERRY, Y SZYFELBEIN, WM TI ONCOCYTIC NODULE - AN UNUSUAL CASE OF A SUBMAXILLARY-GLAND MASS IN AN ELDERLY PATIENT SO ACTA CYTOLOGICA LA English DT Article ID SALIVARY-GLANDS; PAROTID GLAND; NEOPLASMS AB A submaxillary gland mass in an elderly woman was diagnosed as an oncocytic nodule by cutting needle biopsy and was followed with serial fine needle aspiration (FNA) biopsy for seven years. All specimens showed pure populations of oncocytes. Oncocytic nodules of the salivary gland are unusual lesions that may represent hyperplastic proliferations or true neoplasma. Although oncocytic metaplasia is commonly identified in the salivary glands of elderly patients, oncocytes rarely form masses that are targets for needle biopsy. This case suggests that FNA biopsy may be a useful method of evaluating salivary gland lesions in elderly patients who are not candidates for surgery. C1 MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT OTOLARYNGOL,BOSTON,MA 02115. MASSACHUSETTS EYE & EAR HOSP,BOSTON,MA 02114. NR 14 TC 5 Z9 5 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0001-5547 J9 ACTA CYTOL JI Acta Cytol. PD NOV-DEC PY 1990 VL 34 IS 6 BP 827 EP 830 PG 4 WC Pathology SC Pathology GA EP239 UT WOS:A1990EP23900013 PM 2256419 ER PT J AU RUPRECHT, RM HOM, R LEE, J MULLANEY, S BERNARD, L SOSA, MAG FINBERG, RW AF RUPRECHT, RM HOM, R LEE, J MULLANEY, S BERNARD, L SOSA, MAG FINBERG, RW TI NONPRIMATE MODELS FOR EVALUATION OF RETROVIRAL VACCINES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1990 VL 6 IS 11 BP 1357 EP 1357 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EK810 UT WOS:A1990EK81000045 ER PT J AU DELUCA, SA AF DELUCA, SA TI COARCTATION OF THE AORTA SO AMERICAN FAMILY PHYSICIAN LA English DT Article RP DELUCA, SA (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD NOV PY 1990 VL 42 IS 5 BP 1285 EP 1288 PG 4 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EG620 UT WOS:A1990EG62000011 PM 2239636 ER PT J AU MCCLATCHEY, AI KAUFMAN, DL BERSON, EL TOBIN, AJ SHIH, VE GUSELLA, JF RAMESH, V AF MCCLATCHEY, AI KAUFMAN, DL BERSON, EL TOBIN, AJ SHIH, VE GUSELLA, JF RAMESH, V TI SPLICING DEFECT AT THE ORNITHINE AMINOTRANSFERASE (OAT) LOCUS IN GYRATE ATROPHY SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article C1 MASSACHUSETTS GEN HOSP E,NEUROGENET LAB,BLDG 149,13TH ST,BOSTON,MA 02129. UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024. HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,BERMAN GUND LAB STUDY RETINAL DEGENERAT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,AMINO ACID LAB,BOSTON,MA 02114. FU NEI NIH HHS [EY05633, EY02014]; NINDS NIH HHS [NS05096] NR 25 TC 18 Z9 18 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD NOV PY 1990 VL 47 IS 5 BP 790 EP 794 PG 5 WC Genetics & Heredity SC Genetics & Heredity GA EE940 UT WOS:A1990EE94000004 PM 2220818 ER PT J AU FONTAINE, B ROULEAU, GA SEIZINGER, B JEWELL, AF HANSON, MP MARTUZA, RL GUSELLA, JF AF FONTAINE, B ROULEAU, GA SEIZINGER, B JEWELL, AF HANSON, MP MARTUZA, RL GUSELLA, JF TI EQUAL PARENTAL ORIGIN OF CHROMOSOME-22 LOSSES IN HUMAN SPORADIC MENINGIOMA - NO EVIDENCE FOR GENOMIC IMPRINTING SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article C1 MASSACHUSETTS GEN HOSP E,CTR NEUROSCI,MOLEC NEUROGENET LAB,BLDG 149,13TH ST,BOSTON,MA 02129. HARVARD UNIV,SCH MED,BOSTON,MA. MCGILL UNIV,MEM HOSP RES INST,CTR RECH NEUROSCI,MONTREAL H3A 2T5,QUEBEC,CANADA. MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. FU NINDS NIH HHS [NS22224, NS20012, NS24279] NR 29 TC 16 Z9 16 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD NOV PY 1990 VL 47 IS 5 BP 823 EP 827 PG 5 WC Genetics & Heredity SC Genetics & Heredity GA EE940 UT WOS:A1990EE94000009 PM 2220822 ER PT J AU SMITH, MD RUSSELL, EJ LEVY, R CROWELL, RM AF SMITH, MD RUSSELL, EJ LEVY, R CROWELL, RM TI TRANSCATHETER OBLITERATION OF A CEREBELLAR ARTERIOVENOUS-FISTULA WITH PLATINUM COILS SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article C1 NW MEM HOSP,DEPT RADIOL,710 N FAIRBANKS,CHICAGO,IL 60611. MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114. NW MEM HOSP,DEPT NEUROSURG,CHICAGO,IL 60611. NR 17 TC 23 Z9 24 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD NOV-DEC PY 1990 VL 11 IS 6 BP 1199 EP 1202 PG 4 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA EG424 UT WOS:A1990EG42400029 PM 2124058 ER PT J AU CROWLEY, WF WHITCOMB, RW AF CROWLEY, WF WHITCOMB, RW TI GONADOTROPIN-RELEASING-HORMONE DEFICIENCY IN MEN - DIAGNOSIS AND TREATMENT WITH EXOGENOUS GONADOTROPIN-RELEASING-HORMONE SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT SYMP ON PULSATILE GONADOTROPIN-RELEASING HORMONE ( GNRH ) IN CLINIC MEDICINE CY JAN 20, 1990 CL FORT MYERS, FL SP UNIV CALIF SAN FRANCISCO, DEPT OBSTET & GYNECOL & REPROD SCI, UNIV CALIF SAN FRANCISCO, EXTENDED PROGRAMS MED EDUC, ORTHO PHARM RP CROWLEY, WF (reprint author), MASSACHUSETTS GEN HOSP,DEPT REPROD ENDOCRINOL,BARTLETT HALL EXTENS 5,BOSTON,MA 02114, USA. FU NICHD NIH HHS [P30 HD028138, R0IHD15788, U54 HD029164, U54 HD028138] NR 9 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD NOV PY 1990 VL 163 IS 5 SU S BP 1752 EP 1758 PN 2 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA EK521 UT WOS:A1990EK52100007 PM 2122732 ER PT J AU ORMEROD, LD GARSD, A ABELSON, MB KENYON, KR AF ORMEROD, LD GARSD, A ABELSON, MB KENYON, KR TI EFFECTS OF ALTERING THE EICOSANOID PRECURSOR POOL ON NEOVASCULARIZATION AND INFLAMMATION IN THE ALKALI-BURNED RABBIT CORNEA SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,EYE RES INST,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,DEPT OPHTHALMOL,BOSTON,MA 02114. HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT,BOSTON,MA 02115. FU NEI NIH HHS [EY05799, EY06353] NR 61 TC 11 Z9 13 U1 0 U2 0 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD NOV PY 1990 VL 137 IS 5 BP 1243 EP 1252 PG 10 WC Pathology SC Pathology GA EH239 UT WOS:A1990EH23900025 PM 1700621 ER PT J AU PINSKY, JL JETTE, AM BRANCH, LG KANNEL, WB FEINLEIB, M AF PINSKY, JL JETTE, AM BRANCH, LG KANNEL, WB FEINLEIB, M TI THE FRAMINGHAM DISABILITY STUDY - RELATIONSHIP OF VARIOUS CORONARY HEART-DISEASE MANIFESTATIONS TO DISABILITY IN OLDER PERSONS LIVING IN THE COMMUNITY SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article C1 MASSACHUSETTS GEN HOSP,INST HLTH PROFESS,BOSTON,MA 02114. BOSTON UNIV,CTR GERONTOL,BOSTON,MA 02215. BOSTON UNIV,SCH MED,DEPT MED,PREVENT MED & EPIDEMIOL SECT,BOSTON,MA 02118. NATL CTR HLTH STAT,HYATTSVILLE,MD 20782. RP PINSKY, JL (reprint author), NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,FED BLDG,RM 2C08,BETHESDA,MD 20892, USA. FU NHLBI NIH HHS [N01HV52971] NR 17 TC 129 Z9 131 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 1990 VL 80 IS 11 BP 1363 EP 1367 DI 10.2105/AJPH.80.11.1363 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EF801 UT WOS:A1990EF80100016 PM 2240306 ER PT J AU FERRUCCI, JT STARK, DD AF FERRUCCI, JT STARK, DD TI IRON-OXIDE ENHANCED MR-IMAGING OF THE LIVER AND SPLEEN - REVIEW OF THE 1ST-5 YEARS SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP FERRUCCI, JT (reprint author), MASSACHUSETTS GEN HOSP,DEPT RADIOL,55 FRUIT ST,BOSTON,MA 02114, USA. NR 20 TC 222 Z9 226 U1 0 U2 13 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 1990 VL 155 IS 5 BP 943 EP 950 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EE983 UT WOS:A1990EE98300003 PM 2120963 ER PT J AU YOUNG, RH KURMAN, RJ SCULLY, RE AF YOUNG, RH KURMAN, RJ SCULLY, RE TI PLACENTAL SITE NODULES AND PLAQUES - A CLINICOPATHOLOGICAL ANALYSIS OF 20 CASES SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT GYNECOL & OBSTET,BALTIMORE,MD 21205. RP YOUNG, RH (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,JAMES HOMER WRIGHT PATHOL LABS,BOSTON,MA 02114, USA. NR 12 TC 59 Z9 62 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD NOV PY 1990 VL 14 IS 11 BP 1001 EP 1009 DI 10.1097/00000478-199011000-00002 PG 9 WC Pathology; Surgery SC Pathology; Surgery GA EF177 UT WOS:A1990EF17700002 PM 2240354 ER PT J AU TREDGET, EE FALK, N SCOTT, PG HOGG, AM BURKE, JF AF TREDGET, EE FALK, N SCOTT, PG HOGG, AM BURKE, JF TI DETERMINATION OF 4-HYDROXYPROLINE IN COLLAGEN BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY SO ANALYTICAL BIOCHEMISTRY LA English DT Article C1 UNIV ALBERTA,DEPT ORAL BIOL,EDMONTON T6G 2B7,ALBERTA,CANADA. UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2B7,ALBERTA,CANADA. MASSACHUSETTS GEN HOSP,DEPT SURG,BOSTON,MA 02114. RP TREDGET, EE (reprint author), UNIV ALBERTA,DEPT SURG,EDMONTON T6G 2B7,ALBERTA,CANADA. NR 23 TC 32 Z9 33 U1 1 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD NOV 1 PY 1990 VL 190 IS 2 BP 259 EP 265 DI 10.1016/0003-2697(90)90190-K PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA EG984 UT WOS:A1990EG98400019 PM 2291469 ER PT J AU DRESNER, DL BASTA, SJ ALI, HH SCHWARTZ, AF EMBREE, PB WARGIN, WA LAI, AA BRADY, KA SAVARESE, JJ AF DRESNER, DL BASTA, SJ ALI, HH SCHWARTZ, AF EMBREE, PB WARGIN, WA LAI, AA BRADY, KA SAVARESE, JJ TI PHARMACOKINETICS AND PHARMACODYNAMICS OF DOXACURIUM IN YOUNG AND ELDERLY PATIENTS DURING ISOFLURANE ANESTHESIA SO ANESTHESIA AND ANALGESIA LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT ANESTHESIA,BOSTON,MA 02114. BURROUGHS WELLCOME CO,RES TRIANGLE PK,NC 27709. NR 19 TC 29 Z9 29 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD NOV PY 1990 VL 71 IS 5 BP 498 EP 502 PG 5 WC Anesthesiology SC Anesthesiology GA EE234 UT WOS:A1990EE23400008 PM 2145783 ER PT J AU GRAFTON, ST MAZZIOTTA, JC PAHL, JJ STGEORGEHYSLOP, P HAINES, JL GUSELLA, J HOFFMAN, JM BAXTER, LR PHELPS, ME AF GRAFTON, ST MAZZIOTTA, JC PAHL, JJ STGEORGEHYSLOP, P HAINES, JL GUSELLA, J HOFFMAN, JM BAXTER, LR PHELPS, ME TI A COMPARISON OF NEUROLOGICAL, METABOLIC, STRUCTURAL, AND GENETIC EVALUATIONS IN PERSONS AT RISK FOR HUNTINGTONS-DISEASE SO ANNALS OF NEUROLOGY LA English DT Article C1 UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT,LOS ANGELES,CA 90024. MASSACHUSETTS GEN HOSP,NUCL MED LAB,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET LAB,BOSTON,MA 02114. DUKE UNIV,SCH MED,DIV NUCL MED,DURHAM,NC 27706. RP GRAFTON, ST (reprint author), UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,DIV NUCL MED & BIOPHYS,NUCL MED & BIOPHYS LAB,LOS ANGELES,CA 90024, USA. RI Haines, Jonathan/C-3374-2012 FU NIMH NIH HHS [MH00752-02]; NINDS NIH HHS [NS16367, P01-NS-15654] NR 42 TC 90 Z9 90 U1 0 U2 2 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD NOV PY 1990 VL 28 IS 5 BP 614 EP 621 DI 10.1002/ana.410280503 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EG441 UT WOS:A1990EG44100002 PM 1979723 ER PT J AU SABEL, BA DOMINIAK, P HAUSER, W DURING, MJ FREESE, A AF SABEL, BA DOMINIAK, P HAUSER, W DURING, MJ FREESE, A TI EXTENDED LEVODOPA RELEASE FROM A SUBCUTANEOUSLY IMPLANTED POLYMER MATRIX IN RATS SO ANNALS OF NEUROLOGY LA English DT Note C1 UNIV MUNICH,SCH MED,INST PHYSIOL,W-8000 MUNICH 2,GERMANY. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02114. YALE UNIV,SCH MED,DEPT NEUROSURG,NEW HAVEN,CT 06510. MIT,DIV HLTH SCI & TECHNOL,CAMBRIDGE,MA 02139. RP SABEL, BA (reprint author), UNIV MUNICH,SCH MED,INST MED PSYCHOL,GOETHESTR 31,W-8000 MUNICH 2,GERMANY. RI During, Matthew/E-3003-2011; Sabel, Bernhard/E-6579-2013; OI During, Matthew/0000-0002-3797-5026; Sabel, Bernhard/0000-0002-4472-5543 NR 16 TC 12 Z9 12 U1 1 U2 2 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD NOV PY 1990 VL 28 IS 5 BP 714 EP 717 DI 10.1002/ana.410280519 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EG441 UT WOS:A1990EG44100018 PM 2260860 ER PT J AU DELAMONTE, S HEDLEYWHYTE, ET GROWDON, JH AF DELAMONTE, S HEDLEYWHYTE, ET GROWDON, JH TI NEUROPATHOLOGICAL SUBSTRATE OF DEMENTIA IN PARKINSONS-DISEASE - REPLY SO ANNALS OF NEUROLOGY LA English DT Letter RP DELAMONTE, S (reprint author), MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD NOV PY 1990 VL 28 IS 5 BP 724 EP 724 DI 10.1002/ana.410280523 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EG441 UT WOS:A1990EG44100022 ER PT J AU RICE, LB WILLEY, SH PAPANICOLAOU, GA MEDEIROS, AA ELIOPOULOS, GM MOELLERING, RC JACOBY, GA AF RICE, LB WILLEY, SH PAPANICOLAOU, GA MEDEIROS, AA ELIOPOULOS, GM MOELLERING, RC JACOBY, GA TI OUTBREAK OF CEFTAZIDIME RESISTANCE CAUSED BY EXTENDED-SPECTRUM BETA-LACTAMASES AT A MASSACHUSETTS CHRONIC-CARE FACILITY SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article C1 MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. NEW ENGLAND DEACONESS HOSP,BOSTON,MA 02215. YOUVILLE HOSP,CAMBRIDGE,MA 02138. MIRIAM HOSP,PROVIDENCE,RI 02906. FU NIAID NIH HHS [AI20415] NR 27 TC 294 Z9 303 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 1990 VL 34 IS 11 BP 2193 EP 2199 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA EG934 UT WOS:A1990EG93400028 PM 2073110 ER PT J AU PAPANICOLAOU, GA MEDEIROS, AA JACOBY, GA AF PAPANICOLAOU, GA MEDEIROS, AA JACOBY, GA TI NOVEL PLASMID-MEDIATED BETA-LACTAMASE (MIR-1) CONFERRING RESISTANCE TO OXYIMINO-LACTAMS AND ALPHA-METHOXY BETA-LACTAMS IN CLINICAL ISOLATES OF KLEBSIELLA-PNEUMONIAE SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article C1 MIRIAM HOSP,DIV INFECT DIS,PROVIDENCE,RI 02906. MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,BOSTON,MA 02114. FU NIAID NIH HHS [AI20415] NR 50 TC 223 Z9 240 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 1990 VL 34 IS 11 BP 2200 EP 2209 PG 10 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA EG934 UT WOS:A1990EG93400029 PM 1963529 ER PT J AU WU, G WEITER, JJ SANTOS, S GINSBURG, L VILLALOBOS, R AF WU, G WEITER, JJ SANTOS, S GINSBURG, L VILLALOBOS, R TI THE MACULAR PHOTOSTRESS TEST IN DIABETIC-RETINOPATHY AND AGE-RELATED MACULAR DEGENERATION SO ARCHIVES OF OPHTHALMOLOGY LA English DT Article C1 RETINA FDN,EYE RES INST,BOSTON,MA 02114. RP WU, G (reprint author), HARVARD UNIV,SCH MED,JOSLIN DIABET CTR,BEETHAM EYE INST,1 JOSLIN PL,BOSTON,MA 02215, USA. NR 15 TC 26 Z9 26 U1 0 U2 10 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD NOV PY 1990 VL 108 IS 11 BP 1556 EP 1558 PG 3 WC Ophthalmology SC Ophthalmology GA EH234 UT WOS:A1990EH23400024 PM 2244839 ER PT J AU HOMANS, AC BARKER, BE FORMAN, EN CORNELL, CJ DICKERMAN, JD TRUMAN, JT AF HOMANS, AC BARKER, BE FORMAN, EN CORNELL, CJ DICKERMAN, JD TRUMAN, JT TI IMMUNOPHENOTYPIC CHARACTERISTICS OF CEREBROSPINAL-FLUID CELLS IN CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA AT DIAGNOSIS SO BLOOD LA English DT Article C1 UNIV VERMONT,SCH MED,BURLINGTON,VT. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. BROWN UNIV,DIV PEDIAT ONCOL,PROVIDENCE,RI 02912. BROWN UNIV,DEPT PATHOL,PROVIDENCE,RI 02912. DARTMOUTH COLL,HITCHCOCK MED CTR,HANOVER,NH 03756. RP HOMANS, AC (reprint author), RHODE ISL HOSP,DIV PEDIATR ONCOL,MPB 1,PROVIDENCE,RI 02903, USA. NR 41 TC 19 Z9 19 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 1 PY 1990 VL 76 IS 9 BP 1807 EP 1811 PG 5 WC Hematology SC Hematology GA EG398 UT WOS:A1990EG39800018 PM 2171701 ER PT J AU JOCHELSON, M TARBELL, NJ FREEDMAN, AS RABINOWE, SN TAKVORIAN, T SOIFFER, R ANDERSON, K RITZ, J NADLER, LM AF JOCHELSON, M TARBELL, NJ FREEDMAN, AS RABINOWE, SN TAKVORIAN, T SOIFFER, R ANDERSON, K RITZ, J NADLER, LM TI ACUTE AND CHRONIC PULMONARY COMPLICATIONS FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN NON-HODGKINS-LYMPHOMA SO BONE MARROW TRANSPLANTATION LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,JOINT CTR RADIAT THERAPY,DIV TUMOR IMMUNOL,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,DEPT RADIOL,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP JOCHELSON, M (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT RADIOL,DIV ONCORADIOL,44 BINNEY ST,BOSTON,MA 02115, USA. RI Ritz, Jerome/C-7929-2009 OI Ritz, Jerome/0000-0001-5526-4669 FU NCI NIH HHS [5K08 CA01105, CA34183] NR 12 TC 17 Z9 17 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0268-3369 J9 BONE MARROW TRANSPL JI Bone Marrow Transplant. PD NOV PY 1990 VL 6 IS 5 BP 329 EP 331 PG 3 WC Biophysics; Oncology; Hematology; Immunology; Transplantation SC Biophysics; Oncology; Hematology; Immunology; Transplantation GA EK670 UT WOS:A1990EK67000008 PM 2291994 ER PT J AU SEIDEN, MV ODONNELL, WJ WEINBLATT, M LICHT, J AF SEIDEN, MV ODONNELL, WJ WEINBLATT, M LICHT, J TI VASCULITIS WITH RECURRENT PULMONARY HEMORRHAGE IN A LONG-TERM SURVIVOR AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION SO BONE MARROW TRANSPLANTATION LA English DT Article C1 BRIGHAM & WOMENS HOSP,DEPT MED,DIV PULM MED,BOSTON,MA 02115. BRIGHAM & WOMENS HOSP,DEPT RHEUMATOL & IMMUNOL,BOSTON,MA 02115. RP SEIDEN, MV (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CLIN ONCOL,44 BINNEY ST,BOSTON,MA 02115, USA. NR 10 TC 15 Z9 15 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0268-3369 J9 BONE MARROW TRANSPL JI Bone Marrow Transplant. PD NOV PY 1990 VL 6 IS 5 BP 345 EP 347 PG 3 WC Biophysics; Oncology; Hematology; Immunology; Transplantation SC Biophysics; Oncology; Hematology; Immunology; Transplantation GA EK670 UT WOS:A1990EK67000012 PM 2291997 ER PT J AU HILDEBRANDT, N SOKOL, SM RUZECKI, VI DYMKOWSKI, T AF HILDEBRANDT, N SOKOL, SM RUZECKI, VI DYMKOWSKI, T TI COVERT PHONOLOGICAL RECODING IN IMPAIRED WORD RECOGNITION SO BRAIN AND LANGUAGE LA English DT Meeting Abstract C1 MASSACHUSETTS GEN HOSP,INST HLTH PROFESS,NEUROLINGUIST LAB,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0093-934X J9 BRAIN LANG JI Brain Lang. PD NOV PY 1990 VL 39 IS 4 BP 592 EP 593 PG 2 WC Audiology & Speech-Language Pathology; Linguistics; Neurosciences; Psychology, Experimental SC Audiology & Speech-Language Pathology; Linguistics; Neurosciences & Neurology; Psychology GA ER194 UT WOS:A1990ER19400009 ER PT J AU SOKOL, SM MCCLOSKEY, M AF SOKOL, SM MCCLOSKEY, M TI REPRESENTING NOTHING - NEUROPSYCHOLOGICAL EVIDENCE SO BRAIN AND LANGUAGE LA English DT Meeting Abstract C1 HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA. MASSACHUSETTS GEN HOSP, BOSTON, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0093-934X EI 1090-2155 J9 BRAIN LANG JI Brain Lang. PD NOV PY 1990 VL 39 IS 4 BP 595 EP 596 PG 2 WC Audiology & Speech-Language Pathology; Linguistics; Neurosciences; Psychology, Experimental SC Audiology & Speech-Language Pathology; Linguistics; Neurosciences & Neurology; Psychology GA ER194 UT WOS:A1990ER19400017 ER PT J AU SOKOL, SM RUZECKI, VI AF SOKOL, SM RUZECKI, VI TI AN INVESTIGATION OF NUMBER IMPAIRMENTS FOLLOWING POTASSIUM-DEFICIENCY SO BRAIN AND LANGUAGE LA English DT Meeting Abstract C1 HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA. MASSACHUSETTS GEN HOSP, BOSTON, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0093-934X EI 1090-2155 J9 BRAIN LANG JI Brain Lang. PD NOV PY 1990 VL 39 IS 4 BP 595 EP 595 PG 1 WC Audiology & Speech-Language Pathology; Linguistics; Neurosciences; Psychology, Experimental SC Audiology & Speech-Language Pathology; Linguistics; Neurosciences & Neurology; Psychology GA ER194 UT WOS:A1990ER19400016 ER PT J AU DODSON, BA URH, RR MILLER, KW AF DODSON, BA URH, RR MILLER, KW TI RELATIVE POTENCIES FOR BARBITURATE BINDING TO THE TORPEDO ACETYLCHOLINE-RECEPTOR SO BRITISH JOURNAL OF PHARMACOLOGY LA English DT Article C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT ANAESTHESIA,BOSTON,MA 02114. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02114. FU NIGMS NIH HHS [GM 15904, GM 35997] NR 32 TC 17 Z9 17 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0007-1188 J9 BRIT J PHARMACOL JI Br. J. Pharmacol. PD NOV PY 1990 VL 101 IS 3 BP 710 EP 714 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EF079 UT WOS:A1990EF07900035 PM 1963806 ER PT J AU KLAR, E MESSMER, K WARSHAW, AL HERFARTH, C AF KLAR, E MESSMER, K WARSHAW, AL HERFARTH, C TI PANCREATIC ISCHEMIA IN EXPERIMENTAL ACUTE-PANCREATITIS - MECHANISM, SIGNIFICANCE AND THERAPY SO BRITISH JOURNAL OF SURGERY LA English DT Review C1 UNIV HEIDELBERG,DEPT EXPTL SURG,W-6900 HEIDELBERG,GERMANY. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT SURG,BOSTON,MA 02114. RP KLAR, E (reprint author), UNIV HEIDELBERG,DEPT SURG,NEUENHEIMER FELD 110,W-6900 HEIDELBERG,GERMANY. NR 101 TC 237 Z9 254 U1 1 U2 3 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1323 J9 BRIT J SURG JI Br. J. Surg. PD NOV PY 1990 VL 77 IS 11 BP 1205 EP 1210 DI 10.1002/bjs.1800771104 PG 6 WC Surgery SC Surgery GA EJ048 UT WOS:A1990EJ04800003 PM 2252994 ER PT J AU JACOBY, LB PULASKI, K ROULEAU, GA MARTUZA, RL AF JACOBY, LB PULASKI, K ROULEAU, GA MARTUZA, RL TI CLONAL ANALYSIS OF HUMAN MENINGIOMAS AND SCHWANNOMAS SO CANCER RESEARCH LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA 02115. HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,NEUROL SERV,BOSTON,MA 02114. FU NINDS NIH HHS [NS20025, NS24219] NR 21 TC 21 Z9 21 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 1 PY 1990 VL 50 IS 21 BP 6783 EP 6786 PG 4 WC Oncology SC Oncology GA EF205 UT WOS:A1990EF20500004 PM 2208143 ER PT J AU DEZUBE, BJ EDER, JP PARDEE, AB AF DEZUBE, BJ EDER, JP PARDEE, AB TI PHASE-I TRIAL OF ESCALATING PENTOXIFYLLINE DOSE WITH CONSTANT DOSE THIOTEPA SO CANCER RESEARCH LA English DT Article C1 HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT MED,BOSTON,MA 02115. BETH ISRAEL HOSP,DEPT MED,DIV MED ONCOL,BOSTON,MA 02215. RP DEZUBE, BJ (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115, USA. FU NHLBI NIH HHS [HL07516]; PHS HHS [22427] NR 21 TC 29 Z9 29 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 1 PY 1990 VL 50 IS 21 BP 6806 EP 6810 PG 5 WC Oncology SC Oncology GA EF205 UT WOS:A1990EF20500008 PM 2119882 ER PT J AU TEICHER, BA ABRAMS, MJ ROSBE, KW HERMAN, TS AF TEICHER, BA ABRAMS, MJ ROSBE, KW HERMAN, TS TI CYTOTOXICITY, RADIOSENSITIZATION, ANTITUMOR-ACTIVITY, AND INTERACTION WITH HYPERTHERMIA OF A CO(III) MUSTARD COMPLEX SO CANCER RESEARCH LA English DT Article C1 JOHNSON MATTHEY INC,W CHESTER,PA 19380. JOINT CTR RADIAT THERAPY,BOSTON,MA 02115. RP TEICHER, BA (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,44 BINNEY ST,BOSTON,MA 02115, USA. FU NCI NIH HHS [R01-CA36508] NR 34 TC 53 Z9 54 U1 3 U2 6 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD NOV 1 PY 1990 VL 50 IS 21 BP 6971 EP 6975 PG 5 WC Oncology SC Oncology GA EF205 UT WOS:A1990EF20500037 PM 2208163 ER PT J AU WILEMAN, T CARSON, GR SHIH, FF CONCINO, MF TERHORST, C AF WILEMAN, T CARSON, GR SHIH, FF CONCINO, MF TERHORST, C TI THE TRANSMEMBRANE ANCHOR OF THE T-CELL ANTIGEN RECEPTOR BETA-CHAIN CONTAINS A STRUCTURAL DETERMINANT OF PRE-GOLGI PROTEOLYSIS SO CELL REGULATION LA English DT Article C1 T-CELL SCI,PROT EXPRESS GRP,CAMBRIDGE,MA 02139. RP WILEMAN, T (reprint author), HARVARD UNIV,SCH MED,DANA FARBER CANC INST,MOLEC IMMUNOL LAB,BOSTON,MA 02115, USA. FU NIAID NIH HHS [AI-15066] NR 48 TC 30 Z9 30 U1 0 U2 0 PU AMER SOC CELL BIOL PI BETHESDA PA PUBL OFFICE 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1044-2030 J9 CELL REGUL PD NOV PY 1990 VL 1 IS 12 BP 907 EP 919 PG 13 WC Cell Biology SC Cell Biology GA EL265 UT WOS:A1990EL26500004 PM 2151609 ER PT J AU MATHISEN, DJ AF MATHISEN, DJ TI PERCUTANEOUS TRACHEOSTOMY - A CAUTIONARY NOTE SO CHEST LA English DT Editorial Material RP MATHISEN, DJ (reprint author), MASSACHUSETTS GEN HOSP,DEPT GEN THORAC SURG,BOSTON,MA 02114, USA. NR 0 TC 9 Z9 9 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1990 VL 98 IS 5 BP 1049 EP 1049 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG259 UT WOS:A1990EG25900001 PM 2225937 ER PT J AU HURFORD, WE AF HURFORD, WE TI THERMODILUTION RIGHT VENTRICULAR EJECTION FRACTION - REMAINING QUESTIONS SO CHEST LA English DT Editorial Material RP HURFORD, WE (reprint author), MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,BOSTON,MA 02114, USA. RI Hurford, William/G-6386-2013 OI Hurford, William/0000-0003-1201-0313 NR 14 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1990 VL 98 IS 5 BP 1054 EP 1055 DI 10.1378/chest.98.5.1054 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG259 UT WOS:A1990EG25900006 PM 2225942 ER PT J AU LEVINE, SM GIBBONS, WJ BRYAN, CL WALLING, AD BROWN, RW BAILEY, SR CRONIN, T CALHOON, JP TRINKLE, JK JENKINSON, SG AF LEVINE, SM GIBBONS, WJ BRYAN, CL WALLING, AD BROWN, RW BAILEY, SR CRONIN, T CALHOON, JP TRINKLE, JK JENKINSON, SG TI SINGLE LUNG TRANSPLANTATION FOR PRIMARY PULMONARY-HYPERTENSION SO CHEST LA English DT Article C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV CARDIOL,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT SURG,DIV CARDIOTHORAC SURG,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. RP LEVINE, SM (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV PULM CRIT CARE,PULM SECT 111E,7400 MERTON MINTER BLVD,SAN ANTONIO,TX 78284, USA. FU PHS HHS [H-30556] NR 39 TC 86 Z9 87 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1990 VL 98 IS 5 BP 1107 EP 1115 DI 10.1378/chest.98.5.1107 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG259 UT WOS:A1990EG25900018 PM 2225954 ER PT J AU GOTEHRER, A ROA, J STANFORD, GG CHERNOW, B SAHN, SA AF GOTEHRER, A ROA, J STANFORD, GG CHERNOW, B SAHN, SA TI HYPOTHYROIDISM AND PLEURAL EFFUSIONS SO CHEST LA English DT Article C1 MASSACHUSETTS GEN HOSP, DEPT ANESTHESIA, BOSTON, MA 02114 USA. RP GOTEHRER, A (reprint author), MED UNIV S CAROLINA, DIV PULM & CRIT CARE MED, CHARLESTON, SC 29425 USA. NR 13 TC 2 Z9 3 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1990 VL 98 IS 5 BP 1130 EP 1132 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EG259 UT WOS:A1990EG25900022 ER PT J AU OLIVER, LC AF OLIVER, LC TI OCCUPATIONAL AND ENVIRONMENTAL ASTHMA - LEGAL AND ETHICAL ASPECTS OF PATIENT-MANAGEMENT SO CHEST LA English DT Article RP OLIVER, LC (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,PULM CRIT CARE UNIT,BOSTON,MA 02114, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1990 VL 98 IS 5 SU S BP S220 EP S224 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EH100 UT WOS:A1990EH10000016 PM 2146094 ER PT J AU AKINS, CW CARROLL, DL BUCKLEY, MJ DAGGETT, WM HILGENBERG, AD AUSTEN, WG AF AKINS, CW CARROLL, DL BUCKLEY, MJ DAGGETT, WM HILGENBERG, AD AUSTEN, WG TI LATE RESULTS WITH CARPENTIER-EDWARDS PORCINE BIOPROSTHESIS SO CIRCULATION LA English DT Article RP AKINS, CW (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT SURG,CARDIAC SURG UNIT,32 FRUIT ST,BOSTON,MA 02114, USA. NR 10 TC 90 Z9 90 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV PY 1990 VL 82 IS 5 SU S BP 65 EP 74 PG 10 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EJ510 UT WOS:A1990EJ51000010 ER PT J AU MONTALESCOT, G ZAPOL, WM CARVALHO, A ROBINSON, DR TORRES, A LOWENSTEIN, E AF MONTALESCOT, G ZAPOL, WM CARVALHO, A ROBINSON, DR TORRES, A LOWENSTEIN, E TI NEUTRALIZATION OF LOW-MOLECULAR-WEIGHT HEPARIN BY POLYBRENE PREVENTS THROMBOXANE RELEASE AND SEVERE PULMONARY-HYPERTENSION IN AWAKE SHEEP SO CIRCULATION LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT MED,ARTHRITIS UNIT,BOSTON,MA 02114. BROWN UNIV,VET ADM MED CTR,DEPT MED HEMATOL,PROVIDENCE,RI 02912. FU NHLBI NIH HHS [HL-23591, HL-42397]; NIAMS NIH HHS [AR-79427] NR 48 TC 25 Z9 25 U1 0 U2 1 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV PY 1990 VL 82 IS 5 BP 1754 EP 1764 PG 11 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EG886 UT WOS:A1990EG88600020 PM 2171807 ER PT J AU MONTALESCOT, G LOWENSTEIN, E OGLETREE, ML GREENE, EM ROBINSON, DR HARTL, K ZAPOL, WM AF MONTALESCOT, G LOWENSTEIN, E OGLETREE, ML GREENE, EM ROBINSON, DR HARTL, K ZAPOL, WM TI THROMBOXANE RECEPTOR BLOCKADE PREVENTS PULMONARY-HYPERTENSION INDUCED BY HEPARIN-PROTAMINE REACTIONS IN AWAKE SHEEP SO CIRCULATION LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT MED,ARTHRITIS UNIT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. SQUIBB INST MED RES,DEPT PHARMACOL,PRINCETON,NJ 08540. FU NHLBI NIH HHS [HL-23591, HL-42397]; NIAMS NIH HHS [AR-79427] NR 38 TC 43 Z9 43 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV PY 1990 VL 82 IS 5 BP 1765 EP 1777 PG 13 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EG886 UT WOS:A1990EG88600021 PM 2146041 ER PT J AU HABER, E AF HABER, E TI CAN PLASMINOGEN ACTIVATORS BE IMPROVED SO CIRCULATION LA English DT Editorial Material RP HABER, E (reprint author), MASSACHUSETTS GEN HOSP,CARDIAC UNIT,JACKSON 14,BOSTON,MA 02114, USA. NR 23 TC 6 Z9 6 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV PY 1990 VL 82 IS 5 BP 1874 EP 1876 PG 3 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EG886 UT WOS:A1990EG88600036 PM 2121386 ER PT J AU SCHUTZER, SF JASTY, M BRAGDON, CR HARRIGAN, TP HARRIS, WH AF SCHUTZER, SF JASTY, M BRAGDON, CR HARRIGAN, TP HARRIS, WH TI A DOUBLE-BLIND-STUDY ON THE EFFECTS OF A CAPACITIVELY COUPLED ELECTRICAL-FIELD ON BONE INGROWTH INTO POROUS-SURFACED CANINE TOTAL HIP PROSTHESES SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT ORTHOPAED SURG,ORTHOPAED BIOMECH LAB,HIP & IMPLANT UNIT,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 18 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD NOV PY 1990 IS 260 BP 297 EP 304 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA EH410 UT WOS:A1990EH41000046 PM 2225636 ER PT J AU ANDLEY, UP WALSH, A KOCHEVAR, IE REDDAN, JR AF ANDLEY, UP WALSH, A KOCHEVAR, IE REDDAN, JR TI EFFECT OF ULTRAVIOLET-B RADIATION ON PROTEIN-SYNTHESIS IN CULTURED LENS EPITHELIAL-CELLS SO CURRENT EYE RESEARCH LA English DT Article C1 HARVARD UNIV,SCH MED,HOWE LAB OPHTHALMOL,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,DEPT DERMATOL,WELLMAN LABS,BOSTON,MA 02114. OAKLAND UNIV,DEPT BIOL SCI,ROCHESTER,MI 48063. RP ANDLEY, UP (reprint author), MASSACHUSETTS EYE & EAR HOSP,HOWE LAB OPHTHALMOL,243 CHARLES ST,BOSTON,MA 02114, USA. FU NEI NIH HHS [EY00362, EY05681]; NIGMS NIH HHS [GM30755] NR 20 TC 36 Z9 36 U1 0 U2 1 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0271-3683 J9 CURR EYE RES JI Curr. Eye Res. PD NOV PY 1990 VL 9 IS 11 BP 1099 EP 1106 DI 10.3109/02713689008997583 PG 8 WC Ophthalmology SC Ophthalmology GA EK873 UT WOS:A1990EK87300007 PM 2095321 ER PT J AU AUSTIN, CP CEPKO, CL AF AUSTIN, CP CEPKO, CL TI CELLULAR MIGRATION PATTERNS IN THE DEVELOPING MOUSE CEREBRAL-CORTEX SO DEVELOPMENT LA English DT Article C1 HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114. FU NINDS NIH HHS [NS23021] NR 51 TC 146 Z9 146 U1 0 U2 6 PU COMPANY OF BIOLOGISTS LTD PI CAMBRIDGE PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE, CAMBS, ENGLAND CB4 4DL SN 0950-1991 J9 DEVELOPMENT JI Development PD NOV PY 1990 VL 110 IS 3 BP 713 EP & PG 0 WC Developmental Biology SC Developmental Biology GA EL229 UT WOS:A1990EL22900007 PM 2088716 ER PT J AU LOCKE, JL AF LOCKE, JL TI STRUCTURE AND STIMULATION IN THE ONTOGENY OF SPOKEN LANGUAGE SO DEVELOPMENTAL PSYCHOBIOLOGY LA English DT Article C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP LOCKE, JL (reprint author), MASSACHUSETTS GEN HOSP,INST HLTH PROFESS,NEUROLINGUIST LAB,15 RIVER ST,BOSTON,MA 02108, USA. NR 118 TC 14 Z9 14 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0012-1630 J9 DEV PSYCHOBIOL JI Dev. Psychobiol. PD NOV PY 1990 VL 23 IS 7 BP 621 EP 643 DI 10.1002/dev.420230707 PG 23 WC Developmental Biology; Psychology SC Developmental Biology; Psychology GA EK841 UT WOS:A1990EK84100006 PM 2286295 ER PT J AU LOCKE, JL AF LOCKE, JL TI CRANKING UP THE CAPACITY FOR SPOKEN LANGUAGE SO DEVELOPMENTAL PSYCHOBIOLOGY LA English DT Note C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP LOCKE, JL (reprint author), MASSACHUSETTS GEN HOSP,INST HLTH PROFESS,NEUROLINGUIST LAB,15 RIVER ST,BOSTON,MA 02108, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0012-1630 J9 DEV PSYCHOBIOL JI Dev. Psychobiol. PD NOV PY 1990 VL 23 IS 7 BP 757 EP 758 DI 10.1002/dev.420230717 PG 2 WC Developmental Biology; Psychology SC Developmental Biology; Psychology GA EK841 UT WOS:A1990EK84100015 ER PT J AU KOELLER, JM AF KOELLER, JM TI RATIONAL USE OF ANTIBIOTICS IN THE CRITICALLY ILL PATIENT SO DICP-THE ANNALS OF PHARMACOTHERAPY LA English DT Article C1 AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. RP KOELLER, JM (reprint author), UNIV TEXAS,HLTH SCI CTR,AUSTIN,TX 78712, USA. NR 8 TC 1 Z9 1 U1 0 U2 1 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 0012-6578 J9 DICP ANN PHARMAC PD NOV PY 1990 VL 24 IS 11 SU S BP S17 EP S19 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EL348 UT WOS:A1990EL34800004 PM 2270693 ER PT J AU HOOI, SC MAITER, DM MARTIN, JB KOENIG, JI AF HOOI, SC MAITER, DM MARTIN, JB KOENIG, JI TI GALANINERGIC MECHANISMS ARE INVOLVED IN THE REGULATION OF CORTICOTROPIN AND THYROTROPIN SECRETION IN THE RAT SO ENDOCRINOLOGY LA English DT Article C1 MASSACHUSETTS GEN HOSP,NEUROL SERV,NEUROENDOCRINOL LAB,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. RI Hooi, Shing/C-8588-2012 FU NIDDK NIH HHS [DK-40788, DK-39251] NR 46 TC 99 Z9 101 U1 0 U2 3 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD NOV PY 1990 VL 127 IS 5 BP 2281 EP 2289 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EF515 UT WOS:A1990EF51500033 PM 1699744 ER PT J AU WEISS, J DUCA, KA CROWLEY, WF AF WEISS, J DUCA, KA CROWLEY, WF TI GONADOTROPIN-RELEASING HORMONE-INDUCED STIMULATION AND DESENSITIZATION OF FREE ALPHA-SUBUNIT SECRETION MIRRORS LUTEINIZING-HORMONE AND FOLLICLE-STIMULATING-HORMONE IN PERIFUSED RAT PITUITARY-CELLS SO ENDOCRINOLOGY LA English DT Article RP WEISS, J (reprint author), HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,REPROD ENDOCRINE UNIT,BHX-5,BOSTON,MA 02114, USA. FU NICHD NIH HHS [P30 HD028138] NR 31 TC 43 Z9 43 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD NOV PY 1990 VL 127 IS 5 BP 2364 EP 2371 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EF515 UT WOS:A1990EF51500045 PM 2121462 ER PT J AU FRASER, RA KRONENBERG, HM PANG, PKT HARVEY, S AF FRASER, RA KRONENBERG, HM PANG, PKT HARVEY, S TI PARATHYROID-HORMONE MESSENGER-RIBONUCLEIC-ACID IN THE RAT HYPOTHALAMUS SO ENDOCRINOLOGY LA English DT Article C1 UNIV ALBERTA,FAC MED,DEPT PHYSIOL,7-55 MED SCI BLDG,EDMONTON T6G 2H7,ALBERTA,CANADA. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,BOSTON,MA 02114. FU NIDDK NIH HHS [DK-11794] NR 31 TC 42 Z9 42 U1 0 U2 1 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD NOV PY 1990 VL 127 IS 5 BP 2517 EP 2522 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EF515 UT WOS:A1990EF51500066 PM 2226330 ER PT J AU WEAVER, DR REPPERT, SM AF WEAVER, DR REPPERT, SM TI MELATONIN RECEPTORS ARE PRESENT IN THE FERRET PARS TUBERALIS AND PARS-DISTALIS, BUT NOT IN BRAIN SO ENDOCRINOLOGY LA English DT Note C1 HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115. HARVARD UNIV,SCH MED,PROGRAM NEUROSCI,BOSTON,MA 02115. RP WEAVER, DR (reprint author), MASSACHUSETTS GEN HOSP,CHILDRENS SERV,DEV CHRONOBIOL LAB,BOSTON,MA 02114, USA. OI Weaver, David/0000-0001-7941-6719 FU NIDDK NIH HHS [DK42125] NR 20 TC 94 Z9 94 U1 0 U2 1 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD NOV PY 1990 VL 127 IS 5 BP 2607 EP 2609 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EF515 UT WOS:A1990EF51500080 PM 2171920 ER PT J AU FLESCHER, E FOSSUM, D BALLESTER, A MAIZEL, A SHARMA, S TALAL, N AF FLESCHER, E FOSSUM, D BALLESTER, A MAIZEL, A SHARMA, S TALAL, N TI CHARACTERIZATION OF B-CELL GROWTH IN SYSTEMIC LUPUS-ERYTHEMATOSUS - EFFECTS OF RECOMBINANT 12-KDA B-CELL GROWTH-FACTOR, INTERLEUKIN-4 AND TRANSFORMING GROWTH-FACTOR-BETA SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article C1 AUDIE L MURPHY MEM VET ADM MED CTR,CLIN IMMUNOL SECT,SAN ANTONIO,TX 78284. BROWN UNIV,ROGER WILLIAMS GEN HOSP,DEPT PATHOL,PROVIDENCE,RI 02908. RP FLESCHER, E (reprint author), UNIV TEXAS,HLTH SCI CTR,HLTH SCI CTR,DEPT MED,DIV CLIN IMMUNOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. FU NCI NIH HHS [CA 46959, CA 45148] NR 47 TC 20 Z9 20 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD NOV PY 1990 VL 20 IS 11 BP 2425 EP 2430 DI 10.1002/eji.1830201110 PG 6 WC Immunology SC Immunology GA EM972 UT WOS:A1990EM97200009 PM 2253682 ER PT J AU YAOITA, H STRAUSS, HW AF YAOITA, H STRAUSS, HW TI ROLE OF SINGLE PHOTON WALL MOTION AND PERFUSION STUDIES IN THE EVALUATION OF PATIENTS WITH SUSPECTED CORONARY-ARTERY DISEASE SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE LA English DT Review C1 MASSACHUSETTS GEN HOSP,DEPT RADIOL,DIV NUCL MED,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115. NR 98 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-6997 J9 EUR J NUCL MED JI Eur. J. Nucl. Med. PD NOV PY 1990 VL 17 IS 5 BP 269 EP 278 DI 10.1007/BF00812369 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EJ909 UT WOS:A1990EJ90900013 PM 2083561 ER PT J AU ISRAEL, EJ SCHIFFRIN, EJ CARTER, EA FREIBERG, E WALKER, WA AF ISRAEL, EJ SCHIFFRIN, EJ CARTER, EA FREIBERG, E WALKER, WA TI PREVENTION OF NECROTIZING ENTEROCOLITIS IN THE RAT WITH PRENATAL CORTISONE SO GASTROENTEROLOGY LA English DT Article C1 HARVARD UNIV,CHILDRENS HOSP,SCH MED,BOSTON,MA 02115. RP ISRAEL, EJ (reprint author), MASSACHUSETTS GEN HOSP,DEPT PEDIAT GASTROENTEROL & NUTR,BOSTON,MA 02114, USA. FU NICHD NIH HHS [HD12437] NR 26 TC 43 Z9 44 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD NOV PY 1990 VL 99 IS 5 BP 1333 EP 1338 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA ED006 UT WOS:A1990ED00600012 PM 2210242 ER PT J AU MARTIN, DIK ORKIN, SH AF MARTIN, DIK ORKIN, SH TI TRANSCRIPTIONAL ACTIVATION AND DNA-BINDING BY THE ERYTHROID FACTOR GF-1/NF-E1/ERYF-1 SO GENES & DEVELOPMENT LA English DT Article C1 CHILDRENS HOSP MED CTR,DIV HEMATOL ONCOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,DANA FARBER CANC INST,DEPT PEDIAT,BOSTON,MA 02115. NR 55 TC 319 Z9 322 U1 0 U2 4 PU COLD SPRING HARBOR LAB PRESS PI PLAINVIEW PA 1 BUNGTOWN RD, PLAINVIEW, NY 11724 SN 0890-9369 J9 GENE DEV JI Genes Dev. PD NOV PY 1990 VL 4 IS 11 BP 1886 EP 1898 DI 10.1101/gad.4.11.1886 PG 13 WC Cell Biology; Developmental Biology; Genetics & Heredity SC Cell Biology; Developmental Biology; Genetics & Heredity GA EJ316 UT WOS:A1990EJ31600005 PM 2276623 ER PT J AU VOYTAS, DF KONIECZNY, A CUMMINGS, MP AUSUBEL, FM AF VOYTAS, DF KONIECZNY, A CUMMINGS, MP AUSUBEL, FM TI THE STRUCTURE, DISTRIBUTION AND EVOLUTION OF THE TA1 RETROTRANSPOSABLE ELEMENT FAMILY OF ARABIDOPSIS-THALIANA SO GENETICS LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114. HARVARD UNIV,MUSEUM COMPARAT ZOOL,CAMBRIDGE,MA 02138. RP VOYTAS, DF (reprint author), HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115, USA. FU NIGMS NIH HHS [GM07620] NR 34 TC 88 Z9 89 U1 0 U2 0 PU GENETICS PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 SN 0016-6731 J9 GENETICS JI Genetics PD NOV PY 1990 VL 126 IS 3 BP 713 EP 721 PG 9 WC Genetics & Heredity SC Genetics & Heredity GA EF291 UT WOS:A1990EF29100021 PM 2174394 ER PT J AU BUDARF, M HUEBNER, K EMANUEL, B CROCE, CM COPELAND, NG JENKINS, NA DANDREA, AD AF BUDARF, M HUEBNER, K EMANUEL, B CROCE, CM COPELAND, NG JENKINS, NA DANDREA, AD TI ASSIGNMENT OF THE ERYTHROPOIETIN RECEPTOR (EPOR) GENE TO MOUSE CHROMOSOME-9 AND HUMAN CHROMOSOME-19 SO GENOMICS LA English DT Note C1 TEMPLE UNIV,HLTH SCI CTR,SCH MED,FELS INST CANC RES,PHILADELPHIA,PA 19140. NCI,FREDERICK CANC RES FACIL,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21701. HARVARD UNIV,CHILDRENS HOSP,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. RP BUDARF, M (reprint author), UNIV PENN,CHILDRENS HOSP PHILADELPHIA,SCH MED,DIV HUMAN GENET & MOLEC BIOL,PHILADELPHIA,PA 19104, USA. FU NCI NIH HHS [CA 39926, N01-CO-74101]; NIGMS NIH HHS [GM 32592] NR 22 TC 28 Z9 29 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0888-7543 J9 GENOMICS JI Genomics PD NOV PY 1990 VL 8 IS 3 BP 575 EP 578 DI 10.1016/0888-7543(90)90047-X PG 4 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA EF587 UT WOS:A1990EF58700022 PM 1962754 ER PT J AU KIANG, NYS AF KIANG, NYS TI CURIOUS ODDMENTS OF AUDITORY-NERVE STUDIES SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT SYMP CELEBRATING 30 YEARS OF RESEARCH AT THE EATON PEABODY LABORATORY, IN HONOR OF DR N YSS KIANGS 60TH BIRTHDAY : BASIC RESEARCH IN CA CLINICAL ENVIRONMENT CY JUL 05-07, 1989 CL MIT, ENDICOTT HOUSE, DEDHAM, MA HO MIT, ENDICOTT HOUSE C1 MIT,WHITAKER COLL,CAMBRIDGE,MA 02139. MIT,DEPT BRAIN & COGNIT SCI,CAMBRIDGE,MA 02139. HARVARD UNIV,SCH MED,DEPT OTOL & LARYNGOL,BOSTON,MA 02115. MASSACHUSETTS GEN HOSP,NEUROL SERV,BOSTON,MA 02114. RP KIANG, NYS (reprint author), MASSACHUSETTS EYE & EAR HOSP,DEPT OTOLARYNGOL,EATON PEABODY LAB,243 CHARLES ST,BOSTON,MA 02114, USA. NR 34 TC 52 Z9 53 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD NOV PY 1990 VL 49 IS 1-3 BP 1 EP 16 PG 16 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA EL333 UT WOS:A1990EL33300002 PM 2292492 ER PT J AU WIEDERHOLD, ML SHARMA, JS DRISCOLL, BP HARRISON, JL AF WIEDERHOLD, ML SHARMA, JS DRISCOLL, BP HARRISON, JL TI DEVELOPMENT OF THE STATOCYST IN APLYSIA-CALIFORNICA .1. OBSERVATIONS ON STATOCONIAL DEVELOPMENT SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT SYMP CELEBRATING 30 YEARS OF RESEARCH AT THE EATON PEABODY LABORATORY, IN HONOR OF DR N YSS KIANGS 60TH BIRTHDAY : BASIC RESEARCH IN CA CLINICAL ENVIRONMENT CY JUL 05-07, 1989 CL MIT, ENDICOTT HOUSE, DEDHAM, MA HO MIT, ENDICOTT HOUSE C1 AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. RP WIEDERHOLD, ML (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT OTOLARYNGOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 58 TC 17 Z9 17 U1 3 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD NOV PY 1990 VL 49 IS 1-3 BP 63 EP 78 DI 10.1016/0378-5955(90)90095-7 PG 16 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA EL333 UT WOS:A1990EL33300006 PM 2292509 ER PT J AU FULLERTON, BC KIANG, NYS AF FULLERTON, BC KIANG, NYS TI THE EFFECT OF BRAIN-STEM LESIONS ON BRAIN-STEM AUDITORY EVOKED-POTENTIALS IN THE CAT SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT SYMP CELEBRATING 30 YEARS OF RESEARCH AT THE EATON PEABODY LABORATORY, IN HONOR OF DR N YSS KIANGS 60TH BIRTHDAY : BASIC RESEARCH IN CA CLINICAL ENVIRONMENT CY JUL 05-07, 1989 CL MIT, ENDICOTT HOUSE, DEDHAM, MA HO MIT, ENDICOTT HOUSE C1 MASSACHUSETTS GEN HOSP,NEUROL SERV,BOSTON,MA 02114. HARVARD UNIV,SCH MED,DEPT ANAT & CELL BIOL,BOSTON,MA 02115. WHITAKER COLL HLTH SCI TECHNOL & MANAGEMENT,DEPT BRAIN & COGNIT SCI,CAMBRIDGE,MA. MIT,DEPT ELECT ENGN & COMP SCI,CAMBRIDGE,MA 02139. HARVARD UNIV,SCH MED,DEPT OTOL & LARYNGOL,BOSTON,MA 02115. RP FULLERTON, BC (reprint author), MASSACHUSETTS EYE & EAR HOSP,EATON PEABODY LAB AUDITORY PHYSIOL,243 CHARLES ST,BOSTON,MA 02114, USA. FU NINDS NIH HHS [NS13126, NS05885] NR 121 TC 29 Z9 29 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD NOV PY 1990 VL 49 IS 1-3 BP 363 EP 390 DI 10.1016/0378-5955(90)90114-5 PG 28 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA EL333 UT WOS:A1990EL33300025 PM 2292507 ER PT J AU ZUKERBERG, LR ARMIN, AR PISHARODI, L YOUNG, RH AF ZUKERBERG, LR ARMIN, AR PISHARODI, L YOUNG, RH TI TRANSITIONAL CELL-CARCINOMA OF THE URINARY-BLADDER WITH OSTEOCLAST-TYPE GIANT-CELLS - A REPORT OF 2 CASES AND REVIEW OF THE LITERATURE SO HISTOPATHOLOGY LA English DT Review C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. WILLIAM BEAUMONT HOSP,ROYAL OAK,MI 48072. RP ZUKERBERG, LR (reprint author), MASSACHUSETTS GEN HOSP,DEPT PATHOL,WARREN 2,BOSTON,MA 02114, USA. NR 30 TC 26 Z9 26 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0309-0167 J9 HISTOPATHOLOGY JI Histopathology PD NOV PY 1990 VL 17 IS 5 BP 407 EP 411 DI 10.1111/j.1365-2559.1990.tb00760.x PG 5 WC Cell Biology; Pathology SC Cell Biology; Pathology GA EH846 UT WOS:A1990EH84600004 PM 2076867 ER PT J AU GOLD, HK YASUDA, T JANG, IK GUERRERO, JL FALLON, JT LEINBACH, RC COLLEN, D AF GOLD, HK YASUDA, T JANG, IK GUERRERO, JL FALLON, JT LEINBACH, RC COLLEN, D TI ADJUVANT AGENTS TO ENHANCE AND SUSTAIN REPERFUSION WITH T-PA - STUDIES IN EXPERIMENTAL DOG-MODELS SO HOSPITAL FORMULARY LA English DT Article C1 MASSACHUSETTS GEN HOSP,DEPT MED & PATHOL,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ADVANSTAR COMMUNICATIONS PI DULUTH PA 131 W FIRST ST, DULUTH, MN 55802 SN 0098-6909 J9 HOSP FORMUL PD NOV PY 1990 VL 25 SU D BP 28 EP 33 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EK634 UT WOS:A1990EK63400007 ER EF