FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Li, G Millard, SP Peskind, ER Zhang, J Yu, CE Leverenz, JB Mayer, C Shofer, JS Raskind, MA Quinn, JF Galasko, DR Montine, TJ AF Li, Ge Millard, Steven P. Peskind, Elaine R. Zhang, Jing Yu, Chang-En Leverenz, James B. Mayer, Cynthia Shofer, Jane S. Raskind, Murray A. Quinn, Joseph F. Galasko, Douglas R. Montine, Thomas J. TI Cross-Sectional and Longitudinal Relationships Between Cerebrospinal Fluid Biomarkers and Cognitive Function in People Without Cognitive Impairment From Across the Adult Life Span SO JAMA NEUROLOGY LA English DT Article ID ALZHEIMERS-DISEASE; OLDER-ADULTS; FOLLOW-UP; IN-VIVO; DECLINE; BRAIN; DEMENTIA; MODELS; MATTER; RATIO AB IMPORTANCE Age-related cognitive decline among older individuals with normal cognition is a complex trait that potentially derives from processes of aging, inherited vulnerabilities, environmental factors, and common latent diseases that can progress to cause dementia, such as Alzheimer disease and vascular brain injury. OBJECTIVE To use cerebrospinal fluid (CSF) biomarkers to gain insight into this complex trait. DESIGN, SETTING, AND PARTICIPANTS Secondary analyses of an academic multicenter cross-sectional (n = 315) and longitudinal (n = 158) study of 5 neuropsychological tests (Immediate Recall, Delayed Recall, Trail Making Test Parts A and B, and Category Fluency) in cognitively normal individuals aged 21 to 100 years. MAIN OUTCOMES AND MEASURES To investigate the association of these cognitive function test results with age, sex, educational level, inheritance of the epsilon 4 allele of the apolipoprotein E gene, and CSF concentrations of beta-amyloid 42 (A beta 42) and tau (biomarkers of Alzheimer disease) as well as F-2-isoprostanes (measures of free radical injury). RESULTS Age and educational level were broadly predictive of cross-sectional cognitive performance; of the genetic and CSF measures, only greater CSF F-2-isoprostane concentration was significantly associated with poorer executive function (adjusted R-2 <= 0.31). Longitudinal measures of cognitive abilities, except Category Fluency, also were associated broadly with age; of the genetic and CSF measures, only lower baseline CSF A beta 42 concentration was associated with longitudinal measures of immediate and delayed recall (marginal R-2 <= 0.31). CONCLUSIONS AND RELEVANCE Our results suggest that age and educational level accounted for a substantial minority of variance in cross-sectional or longitudinal cognitive test performance in this large group of cognitively normal adults. Latent Alzheimer disease and other diseases that produce free radical injury, such as vascular brain injury, accounted for a small amount of variation in cognitive test performance across the adult human life span. Additional genetic and environmental factors likely contribute substantially to age-related cognitive decline. C1 [Li, Ge; Peskind, Elaine R.; Leverenz, James B.; Shofer, Jane S.; Raskind, Murray A.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Millard, Steven P.; Peskind, Elaine R.; Mayer, Cynthia; Raskind, Murray A.] VA Puget Sound Hlth Care Syst, Vet Affairs VA Northwest Network Mental Illness R, Seattle, WA USA. [Zhang, Jing; Montine, Thomas J.] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA. [Yu, Chang-En] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA. [Yu, Chang-En] VA Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA. [Leverenz, James B.] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA. [Quinn, Joseph F.] Oregon Hlth & Sci Univ, Sch Med, Dept Neurol, Portland, OR 97201 USA. [Quinn, Joseph F.] VA Parkinsons Dis Res Educ & Clin Ctr, Portland, OR USA. [Galasko, Douglas R.] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA. RP Montine, TJ (reprint author), Univ Washington, Sch Med, Dept Pathol, POB 357470, Seattle, WA 98195 USA. EM tmontine@uw.edu FU National Institutes of Health [AG023185, AG031892, AG05131, AG05136, AG08017, AG033693, U01-NS082137]; Department of Veterans Affairs; Oregon Clinical and Translational Research Institute [UL1TR000128]; Jane and Lee Seidman Fund; Nancy and Buster Alvord Endowment FX This work was supported by National Institutes of Health grants AG023185, AG031892, AG05131, AG05136, AG08017, AG033693, and U01-NS082137; the Department of Veterans Affairs; the Oregon Clinical and Translational Research Institute grant UL1TR000128; the Jane and Lee Seidman Fund; and the Nancy and Buster Alvord Endowment. NR 46 TC 12 Z9 12 U1 1 U2 7 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6149 EI 2168-6157 J9 JAMA NEUROL JI JAMA Neurol. PD JUN PY 2014 VL 71 IS 6 BP 742 EP 751 DI 10.1001/jamaneurol.2014.445 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA AN3IF UT WOS:000340479800012 PM 24756381 ER PT J AU Possis, E Bui, T Gavian, M Leskela, J Linardatos, E Loughlin, J Strom, T AF Possis, Elizabeth Bui, Thao Gavian, Margaret Leskela, Jennie Linardatos, Effie Loughlin, Jennifer Strom, Thad TI Driving Difficulties Among Military Veterans: Clinical Needs and Current Intervention Status SO MILITARY MEDICINE LA English DT Review ID POSTTRAUMATIC-STRESS-DISORDER; VEHICLE ACCIDENT SURVIVORS; MENTAL-HEALTH PROBLEMS; RISK-TAKING BEHAVIORS; SENSATION-SEEKING; RESIDENTIAL-TREATMENT; VIETNAM VETERANS; ERA VETERANS; US VETERANS; GULF-WAR AB Military personnel deployed to Iraq and Afghanistan often develop mental health difficulties, which may manifest as problematic driving behavior. Veterans may be more likely to engage in risky driving and to subsequently be involved in motor vehicle accidents and fatalities. This article reviews literature on driving difficulties among military veterans and evaluates available research on the potential pathways that underlie risky driving behavior. Current interventions for problematic driving behaviors are considered, and the necessity of modifying these interventions to address the unique difficulties encountered by military veterans is highlighted. The review concludes with a discussion of clinical implications of these findings and identification of possible avenues for future research and intervention. C1 [Possis, Elizabeth; Leskela, Jennie; Strom, Thad] Minneapolis Vet Affairs Hlth Care Syst, Minneapolis, MN 55417 USA. [Bui, Thao] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. [Gavian, Margaret] North Mem Med Ctr, Psychiat Partial Hosp Program, Robbinsdale, MN 55422 USA. [Linardatos, Effie] Geisel Sch Med Dartmouth, Dept Psychiat, Lebanon, NH 03756 USA. [Loughlin, Jennifer] Barrow Neurol Inst, Phoenix, AZ 85013 USA. RP Possis, E (reprint author), Minneapolis Vet Affairs Hlth Care Syst, One Vet Dr 116A, Minneapolis, MN 55417 USA. NR 58 TC 5 Z9 5 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2014 VL 179 IS 6 BP 633 EP 639 DI 10.7205/MlLMED-D-13-00327 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UM UT WOS:000340806500008 PM 24902130 ER PT J AU Chan, K Hernandez, L Yang, HD Goetz, MB AF Chan, Kee Hernandez, Leilani Yang, Heidi Goetz, Matthew Bidwell TI Comparative Cost Analysis of Clinical Reminder for HIV Testing at the Veterans Affairs Healthcare System SO VALUE IN HEALTH LA English DT Article DE AIDS; cost analysis; Veterans Affairs Healthcare System ID STRATEGIES; SETTINGS; STATEMENT; RECEIPT; TRIAL AB Objective: To estimate the cost and health outcomes associated with a new HIV testing strategy that utilizes routine-based clinical reminders. Methods: We conducted an economic analysis of 1) traditional pretest/post-test counseling; 2) counseling and a new clinical reminders system; and 3) only clinical reminder in the veterans' health care system. A payer perspective decision model was conducted to calculate the 1-year budget impact of three HIV testing strategies. Parameter values were obtained from the literature, including patients' probability of accepting test, and costs associated with HIV testing procedures. Deidentified patient data, including total population screened and number of new HIV cases, were collected from one clinic in Los Angeles, California, from August 2004 to December 2011. Annual total costs and costs per new case were calculated on the basis of parameter values and patient data Sensitivity analyses were conducted to evaluate the robustness of the critical variable on costs. Results: The total cost of the clinical reminder system with pretest counseling was $81,726 over 1 year compared with $109,208 for traditional HIV testing. Under a clinical reminder system with no pretest counseling, the number of HIV tests performed and the number of new diagnoses increased for that year. In addition, cost per new diagnoses was the lowest. Conclusions: The clinical reminder system can reduce the cost per cases identified and promote better performance of HIV testing compared with traditional HIV testing. The fundamental decision model can be used for hospital facilities outside the Veteran Affairs adopting a similar program for improving the HIV testing rate. C1 [Chan, Kee; Hernandez, Leilani; Yang, Heidi] Boston Univ, Sargent Coll, Coll Hlth & Rehabil Sci, Dept Hlth Sci, Boston, MA 02215 USA. [Chan, Kee] Ctr Hlth Qual & Econ Res, Bedford, MA USA. [Goetz, Matthew Bidwell] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Infect Dis Sect, Los Angeles, CA 90095 USA. [Goetz, Matthew Bidwell] VA Greater Los Angeles Healthcare Syst, Dept Med, Infect Dis Sect, Los Angeles, CA USA. RP Chan, K (reprint author), Boston Univ, Sargent Coll, Coll Hlth & Rehabil Sci, 635 Commonwealth Ave, Boston, MA 02215 USA. EM keechan@bu.edu OI Goetz, Matthew/0000-0003-4542-992X NR 14 TC 1 Z9 1 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD JUN PY 2014 VL 17 IS 4 BP 334 EP 339 DI 10.1016/j.jval.2014.03.001 PG 6 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1ON UT WOS:000341082900005 PM 24968992 ER PT J AU Mendez, MF Shapira, JS AF Mendez, Mario F. Shapira, Jill S. TI Kissing or "Osculation" in Frontotemporal Dementia SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES LA English DT Article ID KLUVER-BUCY-SYNDROME; TEMPORAL-LOBE EPILEPSY AB The authors investigated the neuropsychiatry of kissing in frontotemporal dementia. Among 15 patients, two had compulsive social kissing, bitemporal involvement, and Kluver-Bucy symptoms, and four pursued kissing with sexually disinhibited behavior. Future research should clarify the neuropsychiatric significance of kissing behavior. C1 [Mendez, Mario F.; Shapira, Jill S.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90089 USA. [Mendez, Mario F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehavioral Sci, Los Angeles, CA USA. [Mendez, Mario F.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. RP Mendez, MF (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90089 USA. EM mmendez@ucla.edu FU NIA [R01AG034499-03] FX Supported by NIA grant # R01AG034499-03. NR 12 TC 0 Z9 0 U1 0 U2 6 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0895-0172 EI 1545-7222 J9 J NEUROPSYCH CLIN N JI J. Neuropsychiatr. Clin. Neurosci. PD SUM PY 2014 VL 26 IS 3 BP 258 EP 261 PG 4 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA AN3ML UT WOS:000340492100044 PM 24922478 ER PT J AU Byrd, JK Smith, KJ de Almeida, JR Albergotti, WG Davis, KS Kim, SW Johnson, JT Ferris, RL Duvvuri, U AF Byrd, J. Kenneth Smith, Kenneth J. de Almeida, John R. Albergotti, W. Greer Davis, Kara S. Kim, Seungwon W. Johnson, Jonas T. Ferris, Robert L. Duvvuri, Umamaheswar TI Transoral Robotic Surgery and the Unknown Primary: A Cost-Effectiveness Analysis SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE transoral robotic surgery; TORS; occult primary; cost-effectiveness analysis ID SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASES; PRIMARY TUMORS; RADICAL PROSTATECTOMY; EXTRACAPSULAR SPREAD; NECK; HEAD; TECHNOLOGY; MANAGEMENT; PARADIGM AB Objective. To evaluate the cost-effectiveness of transoral robotic surgery (TORS) for the diagnosis and treatment of cervical unknown primary squamous cell carcinoma (CUP). Study Design. Case series with chart review. Setting. Tertiary academic hospital. Subjects and Methods. A retrospective chart review was performed on patients with new occult primary squamous cell carcinoma of the head and neck with nondiagnostic imaging and/or endoscopy who were treated with TORS at a tertiary hospital between 2009 and 2012. Direct costs were obtained from the hospital's billing system, and national data were used for inpatient hospital costs and physician fees. The proportion of tumors found in 3 strategies was used as effectiveness to calculate the incremental cost-effectiveness ratio. Results. In total, 206 head and neck robotic cases were performed at our institution between December 2009 and December 2012. Three surgeons performed TORS on 22 patients for occult primary squamous cell carcinoma. The primary tumor was located in 19 of 22 patients (86.4%). The incremental cost-effectiveness ratio for sequential and simultaneous examination under anesthesia with tonsillectomy (EUA) and TORS base of tongue resection was $8619 and $5774 per additional primary identified, respectively. Conclusion. Sequential EUA followed by TORS is associated with an incremental cost-effectiveness ratio of $8619 compared with traditional EUA alone. Bilateral base of tongue resection should be considered in the workup of these patients, particularly if the palatine tonsils have already been removed. C1 [Byrd, J. Kenneth; Albergotti, W. Greer; Davis, Kara S.; Kim, Seungwon W.; Johnson, Jonas T.; Ferris, Robert L.; Duvvuri, Umamaheswar] Univ Pittsburgh, Med Ctr, Dept Otolaryngol, Pittsburgh, PA 15213 USA. [Smith, Kenneth J.] Univ Pittsburgh, Med Ctr, Dept Med, Pittsburgh, PA 15213 USA. [de Almeida, John R.] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada. [Duvvuri, Umamaheswar] VA Pittsburgh Hlth Syst, Pittsburgh, PA USA. RP Byrd, JK (reprint author), Univ Pittsburgh, Med Ctr, Dept Otolaryngol, 200 Lothrop St,Suite 500, Pittsburgh, PA 15213 USA. EM byrdjk@upmc.edu FU Department of Veterans Affairs FX This work was supported in part by funds from the Department of Veterans Affairs; this work does not reflect the views of the U.S. government or the Department of Veterans Affairs. NR 22 TC 17 Z9 17 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUN PY 2014 VL 150 IS 6 BP 976 EP 982 DI 10.1177/0194599814525746 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA AN2YC UT WOS:000340451000014 PM 24618502 ER PT J AU Morgenroth, DC Medverd, JR Seyedali, M Czerniecki, JM AF Morgenroth, David C. Medverd, Jonathan R. Seyedali, Mahyo Czerniecki, Joseph M. TI The relationship between knee joint loading rate during walking and degenerative changes on magnetic resonance imaging SO CLINICAL BIOMECHANICS LA English DT Article DE Osteoarthritis; Knee; Gait ID TRANS-TIBIAL AMPUTATION; ADDUCTION MOMENT; TIBIOFEMORAL OSTEOARTHRITIS; DISEASE SEVERITY; IN-VITRO; CARTILAGE; GAIT; BONE; IMPACT; STRENGTH AB Background: While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee joint loading rate during walking and osteoarthritis has not yet been sufficiently studied in humans. Methods: Twenty-eight participants (14 transfemoral amputees and 14 age and body mass matched controls) underwent knee MRI with subsequent assessment using the semiquantitative Whole-Organ Magnetic Resonance Image Score. Each subject also underwent gait analysis in order to determine knee adduction moment loading rate, peak, and impulse and an exploratory measure, knee adduction moment rate * magnitude. Findings; Significant correlations were found between medial tibiofemoral joint degeneration and knee adduction moment peak (slope = 0.42 [SE 0.20]; P = .037), loading rate (slope = 12.3 [SE 3.2]; P = .0004), and rate * magnitude (slope = 437 [SE 100]; P < .0001). These relationships continued to be significant after adjusting for body mass or subject type. The relationship between medial knee semiquantitative MRI score and knee adduction moment loading rate and rate * magnitude continued to be significant even after adjusting for peak moment (P < .0001), however, the relationship between medial knee semiquantitative MRI score and peak moment was no longer significant after adjusting for either loading rate or rate * magnitude (P > .2 in both cases). Interpretation; This study suggests an independent relationship between knee adduction moment loading rate and medial tibiofemoral joint degeneration. Our results support the hypothesis that rate of loading, represented by the knee adduction moment loading rate, is strongly associated with medial tibiofemoral joint degeneration independent of knee adduction moment peak and impulse. Published by Elsevier Ltd. C1 [Morgenroth, David C.; Seyedali, Mahyo; Czerniecki, Joseph M.] VAPSHCS, Dept Vet Affairs, Rehabil Res & Dev Ctr Excellence, Seattle, WA USA. [Medverd, Jonathan R.] VAPSHCS, Dept Vet Affairs, Dept Radiol, Seattle, WA USA. [Morgenroth, David C.; Czerniecki, Joseph M.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Medverd, Jonathan R.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. RP Morgenroth, DC (reprint author), VA Puget Sound Hlth Care Syst, RCS 117,1660 S Columbian Way, Seattle, WA 98108 USA. EM dmorgen@uw.edu FU U.S. Department of Veterans Affairs, Office of Research and Development (RRD Center) [A4843C]; National Institutes of Health (NIH) [K12 HD001097] FX This material is based on work supported in part by the U.S. Department of Veterans Affairs, Office of Research and Development (RR&D Center Grant A4843C). Additionally, David Morgenroth's work on this project was supported by the National Institutes of Health (NIH grant K12 HD001097). None of the authors have any conflicts of interest related to this work. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 43 TC 7 Z9 7 U1 0 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD JUN PY 2014 VL 29 IS 6 BP 664 EP 670 DI 10.1016/j.clinbiomech.2014.04.008 PG 7 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA AN1KH UT WOS:000340340700010 PM 24820134 ER PT J AU Soltis, K Acierno, R Gros, DF Yoder, M Tuerk, PW AF Soltis, Kathryn Acierno, Ron Gros, Daniel F. Yoder, Matthew Tuerk, Peter W. TI Post-Traumatic Stress Disorder: Ethical and Legal Relevance to the Criminal Justice System SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID NATIONAL COMORBIDITY SURVEY; INTERNATIONAL CONSENSUS GROUP; COGNITIVE-PROCESSING THERAPY; MENTAL-HEALTH-SERVICES; PROLONGED EXPOSURE; PSYCHIATRIC-DISORDERS; MILITARY PERSONNEL; RISK-FACTORS; US VETERANS; GULF-WAR C1 [Soltis, Kathryn] Med Univ S Carolina, Natl Crime Victims Res & Treatment Ctr, Charleston, SC 29425 USA. [Acierno, Ron; Tuerk, Peter W.] Ralph H Johnson VA Med Ctr, PTSD Clin Team, Charleston, SC USA. [Acierno, Ron] Med Univ S Carolina, Coll Nursing, Charleston, SC USA. [Gros, Daniel F.] Ralph H Johnson VAMC, Mental Hlth Primary Care Integrat Program, Charleston, SC USA. [Gros, Daniel F.; Yoder, Matthew; Tuerk, Peter W.] MUSC, Dept Psychiat & Behav Sci, Charleston, SC USA. [Yoder, Matthew] Ralph H Johnson Vet Affairs Med Ctr, Posttraumat Stress Clin, Charleston, SC USA. [Tuerk, Peter W.] APA Accredited MUSC VA Psychol Internship Program, Charleston, SC USA. RP Soltis, K (reprint author), Med Univ S Carolina, Natl Crime Victims Res & Treatment Ctr, Charleston, SC 29425 USA. NR 81 TC 2 Z9 2 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD SUM PY 2014 VL 42 IS 2 SI SI BP 147 EP 154 DI 10.1111/jlme.12130 PG 8 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA AM2XI UT WOS:000339714400006 PM 25040378 ER PT J AU Hamner, MB AF Hamner, Mark B. TI The Role of PTSD in Adjudicating Violent Crimes SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; DOMESTIC VIOLENCE; ABUSE; PREVALENCE; VICTIMS C1 [Hamner, Mark B.] Med Univ S Carolina, Charleston, SC 29425 USA. [Hamner, Mark B.] Ralph H Johnson VA Med Ctr, PTSD Clin, Charleston, SC USA. [Hamner, Mark B.] Amer Psychiat Assoc, Washington, DC 20005 USA. RP Hamner, MB (reprint author), Med Univ S Carolina, Charleston, SC 29425 USA. NR 19 TC 2 Z9 2 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD SUM PY 2014 VL 42 IS 2 SI SI BP 155 EP 160 DI 10.1111/jlme.12131 PG 6 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA AM2XI UT WOS:000339714400007 PM 25040379 ER PT J AU Wangelin, BC Tuerk, PW AF Wangelin, Bethany C. Tuerk, Peter W. TI PTSD in Active Combat Soldiers: To Treat or Not to Treat SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; PROLONGED EXPOSURE THERAPY; OPERATION IRAQI FREEDOM; NATIONAL-GUARD SOLDIERS; HEALTH TREATMENT-SEEKING; MENTAL-HEALTH; PSYCHOLOGICAL SYMPTOMS; MARITAL SATISFACTION; TREATMENT SERVICES; VIETNAM VETERANS C1 [Wangelin, Bethany C.; Tuerk, Peter W.] Ralph H Johnson VA Med Ctr, PTSD Clin Team, Charleston, SC 29401 USA. [Tuerk, Peter W.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC USA. [Tuerk, Peter W.] APA Accredited MUSC VA Psychol Internship Program, Charleston, SC USA. RP Wangelin, BC (reprint author), Ralph H Johnson VA Med Ctr, PTSD Clin Team, Charleston, SC 29401 USA. NR 81 TC 2 Z9 2 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD SUM PY 2014 VL 42 IS 2 SI SI BP 161 EP 170 DI 10.1111/jlme.12132 PG 10 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA AM2XI UT WOS:000339714400008 PM 25040380 ER PT J AU Thase, ME AF Thase, Michael E. TI Combining Cognitive Therapy and Pharmacotherapy for Depressive Disorders: A Review of Recent Developments SO INTERNATIONAL JOURNAL OF COGNITIVE THERAPY LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; BEHAVIORAL-ANALYSIS SYSTEM; MAJOR DEPRESSION; RECURRENT DEPRESSION; BIPOLAR DISORDER; CHRONIC FORMS; PSYCHOTHERAPY; MEDICATION; PREVENTION; NEFAZODONE AB Cognitive Behavior Therapy (CBT) and pharmacotherapy, including antidepressants for depressive disorders and mood stabilizers for bipolar disorders, are effective and widely disseminated treatments that often are considered the first line of therapy for these common, yet potentially disabling conditions. Given the imperfect and often unpredictable effects of these treatments, as well as the obvious differences in the aspects of depressive syndromes that they target, there has been a longstanding and widespread belief that these strategies will have additive effects. After 30-plus years of research-and slow progress-it now seems reasonably clear that CBT and pharmacotherapy have a partially additive benefit for patients with depressive disorders; this effect is proposed to be largely explained by improving outcomes for patients who are less responsive to one or both of the monotherapies. This article summarizes the research literature, including newer studies that examining differential impact on neural circuits and the metabolic activity of relevant brain regions. C1 [Thase, Michael E.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Thase, Michael E.] Univ Penn, Med Ctr, Philadelphia Vet Affairs Med Ctr, Philadelphia, PA 19104 USA. RP Thase, ME (reprint author), 3535 Market St,Suite 670, Philadelphia, PA 19104 USA. EM thase@mail.med.upenn.edu NR 38 TC 1 Z9 1 U1 1 U2 23 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 1937-1209 EI 1937-1217 J9 INT J COGN THER JI Int. J. Cogn. Ther. PD JUN PY 2014 VL 7 IS 2 BP 108 EP 121 PG 14 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AM1NI UT WOS:000339612800002 ER PT J AU Doran, KM Curry, LA Vashi, AA Platis, S Rowe, M Gang, M Vaca, FE AF Doran, Kelly M. Curry, Leslie A. Vashi, Anita A. Platis, Stephanie Rowe, Michael Gang, Maureen Vaca, Federico E. TI "Rewarding and Challenging at the Same Time": Emergency Medicine Residents' Experiences Caring for Patients Who Are Homeless SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID SAFETY-NET EMERGENCY; STUDENTS ATTITUDES; CARE; PEOPLE; URBAN; POPULATION; DEPARTMENTS; INTERVENTION; PHYSICIANS; LEARNERS AB Objectives: The objectives were to examine how emergency medicine (EM) residents learn to care for patients in the emergency department (ED) who are homeless and how providing care for patients who are homeless influences residents' education and professional development as emergency physicians. Methods: We conducted in-depth, one-on-one interviews with EM residents from two programs. A random sample of residents stratified by training year was selected from each site. Interviews were digitally recorded and professionally transcribed. A team of researchers with diverse content-relevant expertise reviewed transcripts independently and applied codes to text segments using a grounded theory approach. The team met regularly to reconcile differences in code interpretations. Data collection and analysis occurred iteratively, and interviews continued until theoretical saturation was achieved. Results: Three recurring themes emerged from 23 resident interviews. First, residents learn unique aspects of EM by caring for patients who are homeless. This learning encompasses both specific knowledge and skills (e. g., disease processes infrequently seen in other populations) and professional development as an emergency physician (e. g., the core value of service in EM). Second, residents learn how to care for patients who are homeless through experience and informal teaching rather than through a formal curriculum. Residents noted little formal curricular time dedicated to homelessness and instead learned during clinical shifts through personal experience and by observing more senior physicians. One unique method of learning was through stories of "misses," in which patients who were homeless had bad outcomes. Third, caring for patients who are homeless affects residents emotionally in complex, multifaceted ways. Emotions were dominated by feelings of frustration. This frustration was often related to feelings of futility in truly helping homeless patients, particularly for patients who were frequent visitors to the ED and who had concomitant alcohol dependence. Conclusions: Caring for ED patients who are homeless is an important part of EM residency training. Our findings suggest the need for increased formal curricular time dedicated to the unique medical and social challenges inherent in treating patients who are homeless, as well as enhanced support and resources to improve the ability of residents to care for this vulnerable population. Future research is needed to determine if such interventions improve EM resident education and, ultimately, result in improved care for ED patients who are homeless. (C) 2014 by the Society for Academic Emergency Medicine C1 [Doran, Kelly M.; Vashi, Anita A.] Yale Univ, Sch Med, Robert Wood Johnson Fdn Clin Scholars Program, New Haven, CT USA. [Doran, Kelly M.; Vashi, Anita A.] US Dept Vet Affairs, New Haven, CT USA. [Doran, Kelly M.; Vashi, Anita A.; Vaca, Federico E.] Yale Univ, Sch Med, Dept Emergency Med, New Haven, CT USA. [Curry, Leslie A.; Platis, Stephanie] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Curry, Leslie A.] Yale Univ, Sch Med, Robert Wood Johnson Fdn RWJF Clin Scholars Progra, New Haven, CT USA. [Rowe, Michael] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Doran, Kelly M.; Gang, Maureen] NYU, Bellevue Hosp Ctr, Sch Med, Dept Emergency Med, New York, NY 10016 USA. RP Doran, KM (reprint author), NYU, Bellevue Hosp Ctr, Sch Med, Dept Emergency Med, New York, NY 10016 USA. EM kelly.doran@nyumc.org FU RWJF; U.S. Department of Veterans Affairs through the RWJF Clinical Scholars Program FX Financial support for this study was received from the RWJF and the U.S. Department of Veterans Affairs through the RWJF Clinical Scholars Program. The funder had no role in the study conduct or presentation of the results. NR 44 TC 1 Z9 1 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD JUN PY 2014 VL 21 IS 6 BP 673 EP 679 DI 10.1111/acem.12388 PG 7 WC Emergency Medicine SC Emergency Medicine GA AL5GR UT WOS:000339162200009 PM 25039552 ER PT J AU Myaskovsky, L Pleis, J Dew, M Switzer, G Shapiro, R AF Myaskovsky, L. Pleis, J. Dew, M. Switzer, G. Shapiro, R. TI Race, Experience of Discrimination, and Other Non-Medical Factors Predict Differences in Acceptance for Kidney Transplantation. SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT World Transplant Congress CY JUL 26-31, 2014 CL San Francisco, CA C1 [Myaskovsky, L.; Pleis, J.; Switzer, G.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Myaskovsky, L.; Pleis, J.; Dew, M.; Switzer, G.; Shapiro, R.] Univ Pittsburgh, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2014 VL 14 SU 3 MA B1197 BP 827 EP 827 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA AJ9LU UT WOS:000338033303588 ER PT J AU Myaskovsky, L Pleis, J Ramkumar, M Langone, A Saha, S Thomas, C AF Myaskovsky, L. Pleis, J. Ramkumar, M. Langone, A. Saha, S. Thomas, C. TI Fewer Race Disparities in the National VA Kidney Transplant Program. SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT World Transplant Congress CY JUL 26-31, 2014 CL San Francisco, CA C1 [Myaskovsky, L.; Pleis, J.; Ramkumar, M.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Myaskovsky, L.; Pleis, J.; Ramkumar, M.] Univ Pittsburgh, Pittsburgh, PA USA. [Langone, A.] VA Tennessee Valley Healthcare Syst, Nashville, TN USA. [Saha, S.] Portland VA Med Ctr, Portland, OR 97239 USA. [Thomas, C.] Iowa City VA Healthcare Syst, Iowa City, IA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2014 VL 14 SU 3 MA B1196 BP 827 EP 827 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA AJ9LU UT WOS:000338033303587 ER PT J AU Stein, DJ McLaughlin, KA Koenen, KC Atwoli, L Friedman, MJ Hill, ED Maercker, A Petukhova, M Shahly, V van Ommeren, M Alonso, J Borges, G de Girolamo, G de Jonge, P Demyttenaere, K Florescu, S Karam, EG Kawakami, N Matschinger, H Okoliyski, M Posada-Villa, J Scott, KM Viana, MC Kessler, RC AF Stein, Dan J. McLaughlin, Katie A. Koenen, Karestan C. Atwoli, Lukoye Friedman, Matthew J. Hill, Eric D. Maercker, Andreas Petukhova, Maria Shahly, Victoria van Ommeren, Mark Alonso, Jordi Borges, Guilherme de Girolamo, Giovanni de Jonge, Peter Demyttenaere, Koen Florescu, Silvia Karam, Elie G. Kawakami, Norito Matschinger, Herbert Okoliyski, Michail Posada-Villa, Jose Scott, Kate M. Viana, Maria Carmen Kessler, Ronald C. TI DSM-5 AND ICD-11 DEFINITIONS OF POSTTRAUMATIC STRESS DISORDER: INVESTIGATING "NARROW" AND "BROAD" APPROACHES SO DEPRESSION AND ANXIETY LA English DT Article DE Posttraumatic stress disorder; World Mental Health Surveys; epidemiology; nosology; DSM-IV; DSM-5; ICD-10; ICD-11 ID CLINICAL-SIGNIFICANCE CRITERION; CONFIRMATORY FACTOR-ANALYSIS; MENTAL-HEALTH; FRIEDMAN 2013; PTSD; SYMPTOMS; IMPACT; CLASSIFICATION; COMORBIDITY; PROPOSALS AB Background: The development of the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and ICD-11 has led to reconsideration of diagnostic criteria for posttraumatic stress disorder (PTSD). The World Mental Health (WMH) Surveys allow investigation of the implications of the changing criteria compared to DSM-IV and ICD-10. Methods: WMH Surveys in 13 countries asked respondents to enumerate all their lifetime traumatic events (TEs) and randomly selected one TE per respondent for PTSD assessment. DSM-IV and ICD-10 PTSD were assessed for the 23,936 respondents who reported lifetime TEs in these surveys with the fully structured Composite International Diagnostic Interview (CIDI). DSM-5 and proposed ICD-11 criteria were approximated. Associations of the different criteria sets with indicators of clinical severity (distress-impairment, suicidality, comorbid fear-distress disorders, PTSD symptom duration) were examined to investigate the implications of using the different systems. Results: A total of 5.6% of respondents met criteria for "broadly defined" PTSD (i.e., full criteria in at least one diagnostic system), with prevalence ranging from 3.0% with DSM-5 to 4.4% with ICD-10. Only one-third of broadly defined cases met criteria in all four systems and another one third in only one system (narrowly defined cases). Between-system differences in indicators of clinical severity suggest that ICD-10 criteria are least strict and DSM-IV criteria most strict. The more striking result, though, is that significantly elevated indicators of clinical significance were found even for narrowly defined cases for each of the four diagnostic systems. Conclusions: These results argue for a broad definition of PTSD defined by any one of the different systems to capture all clinically significant cases of PTSD in future studies. Depression and Anxiety 31: 494-505, 2014. (C) 2014 Wiley Periodicals, Inc. C1 [Stein, Dan J.] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa. [McLaughlin, Katie A.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA. [Koenen, Karestan C.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. [Atwoli, Lukoye] Moi Univ, Dept Psychiat, Eldoret, Kenya. [Friedman, Matthew J.] US Dept Vet Affairs, Natl Ctr PTSD, VA Med Ctr, White River Jct, VT USA. [Hill, Eric D.; Petukhova, Maria; Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Maercker, Andreas; Shahly, Victoria] Univ Zurich, Dept Psychol, Div Psychopathol, CH-8006 Zurich, Switzerland. [van Ommeren, Mark] WHO, Dept Mental Hlth & Subst Abuse, CH-1211 Geneva, Switzerland. [Alonso, Jordi] Hosp Mar, IMIM, Hlth Serv Res Unit, Barcelona, Spain. [Alonso, Jordi] CIBER Epidemol & Salud Publ CIBERESP, Barcelona, Spain. [Borges, Guilherme] Natl Inst Psychiat Mexico, Dept Epidemiol Res, Div Epidemiol & Psychosocial Res, Mexico City, DF, Mexico. [Borges, Guilherme] Metropolitan Autonomous Univ, Mexico City, DF, Mexico. [de Girolamo, Giovanni] IRCCS Ctr S Giovanni Dio Fatebenefratelli, Brescia, Italy. [de Jonge, Peter] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat PdJ, NL-9713 AV Groningen, Netherlands. [Demyttenaere, Koen] Univ Hosp Gasthuisberg, Dept Psychiat, Leuven, Belgium. [Florescu, Silvia] Natl Sch Publ Hlth Management & Profess Dev, Hlth Serv Res & Evaluat Ctr, Bucharest, Romania. [Karam, Elie G.] Balamand Univ, St George Hosp Univ Med Ctr, Fac Med, IDRAAC,MIND, Beirut, Lebanon. [Kawakami, Norito] Univ Tokyo, Sch Publ Hlth, Dept Mental Hlth, Tokyo, Japan. [Matschinger, Herbert] Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, Publ Hlth Res Unit HM, D-04109 Leipzig, Germany. [Okoliyski, Michail] Minist Hlth, Natl Ctr Publ Hlth & Anal, Dept Mental Hlth, Sofia, Bulgaria. [Posada-Villa, Jose] Pontificia Univ Javeriana, Inst Colombiano Sistema Nervioso, Bogota, Colombia. [Scott, Kate M.] Univ Otago, Dept Psychol Med, Dunedin, New Zealand. [Viana, Maria Carmen] Univ Fed Espirito Santo, Dept Social Med, Vitoria, Brazil. RP Stein, DJ (reprint author), Univ Cape Town, Groote Schuur Hosp, Dept Psychiat, J2,Anzio Rd, ZA-7925 Cape Town, South Africa. EM dan.stein@uct.ac.za RI Stein, Dan/A-1752-2008; Alonso, Jordi/A-5514-2010 OI Stein, Dan/0000-0001-7218-7810; Alonso, Jordi/0000-0001-8627-9636; Borges, Guilherme/0000-0002-3269-0507; Atwoli, Lukoye/0000-0001-7710-9723; McLaughlin, Katie/0000-0002-1362-2410 FU United States National Institute of Mental Health [R01MH070884]; John D. and Catherine T. MacArthur Foundation; Pfizer Foundation; US Public Health Service [R13-MH066849, R01-MH069864, R01-MH092526, R01-DA016558]; Fogarty International Center [FIRCA R03-TW006481]; Pan American Health Organization; Eli Lilly & Company Foundation; Ortho-McNeil Pharmaceutical, Inc.; GlaxoSmithKline; Bristol-Myers Squibb; Shire Pharmaceuticals; State of Sao Paulo Research Foundation (FAPESP) [03/00204-3]; European Commission [QLG5-1999-01042, SANCO 2004123]; Piedmont Region; Fondo de Investigacion Sanitaria; Instituto de Salud Carlos III [FIS 00/0028, CIBER CB06/02/0046, RETICS RD06/0011 REM-TAP]; Ministerio de Ciencia y Tecnologia, Spain [SAF 2000-158-CE]; Departament de Salut, Generalitat de Catalunya; Japan Ministry of Health, Labour and Welfare [H13-SHOGAI-023, H14-TOKUBETSU-026, H16-KOKORO-013]; National Institute of Health/Fogarty International Center [R03 TW006481-01]; Astra Zeneca; Hikma Pharm; Janssen Cilag; MSD; Novartis; Sanofi Aventis; Servier; National Institute of Psychiatry Ramon de la Fuente [INPRFMDIES 4280]; National Council on Science and Technology [CONACyT-G30544-H]; Health & Social Care Research & Development Division; Champalimaud Foundation; Gulbenkian Foundation; Foundation for Science and Technology (FCT); Ministry of Health; Ministry of Public Health; National Institute of Mental Health (NIMH) [U01-MH60220] FX Contract grant sponsor: United States National Institute of Mental Health; Contract grant number: R01MH070884; Contract grant sponsor: John D. and Catherine T. MacArthur Foundation; Contract grant sponsor: The Pfizer Foundation; Contract grant sponsor: The US Public Health Service; Contract grant numbers: R13-MH066849, R01-MH069864, R01-MH092526, and R01-DA016558; Contract grant sponsor: Fogarty International Center; Contract grant number: FIRCA R03-TW006481; Contract grant sponsor: The Pan American Health Organization; Contract grant sponsor: the Eli Lilly & Company Foundation; Contract grant sponsor: Ortho-McNeil Pharmaceutical, Inc.; Contract grant sponsor: GlaxoSmithKline; Contract grant sponsor: Bristol-Myers Squibb; Contract grant sponsor: Shire Pharmaceuticals; Contract grant sponsor: State of Sao Paulo Research Foundation (FAPESP) Thematic Project; Contract grant number: 03/00204-3; Contract grant sponsor: European Commission; Contract grant numbers: QLG5-1999-01042 and SANCO 2004123; Contract grant sponsor: The Piedmont Region; Contract grant sponsor: Fondo de Investigacion Sanitaria; Contract grant sponsor: Instituto de Salud Carlos III; Contract grant number: FIS 00/0028; Contract grant sponsor: Ministerio de Ciencia y Tecnologia, Spain; Contract grant number: SAF 2000-158-CE; Contract grant sponsor: Departament de Salut, Generalitat de Catalunya; Contract grant sponsor: Instituto de Salud Carlos III; Contract grant numbers: CIBER CB06/02/0046 and RETICS RD06/0011 REM-TAP; Contract grant sponsor: Japan Ministry of Health, Labour and Welfare; Contract grant numbers: H13-SHOGAI-023, H14-TOKUBETSU-026, and H16-KOKORO-013; Contract grant sponsor: National Institute of Health/Fogarty International Center; Contract grant number: R03 TW006481-01; Contract grant sponsor: Astra Zeneca; Contract grant sponsor: Hikma Pharm; Contract grant sponsor: Janssen Cilag; Contract grant sponsor: MSD; Contract grant sponsor: Novartis; Contract grant sponsor: Sanofi Aventis; Contract grant sponsor: Servier; Contract grant sponsor: The National Institute of Psychiatry Ramon de la Fuente; Contract grant number: INPRFMDIES 4280; Contract grant sponsor: National Council on Science and Technology; Contract grant number: CONACyT-G30544-H; Contract grant sponsor: Health & Social Care Research & Development Division; Contract grant sponsor: Champalimaud Foundation; Contract grant sponsor: Gulbenkian Foundation; Contract grant sponsor: Foundation for Science and Technology (FCT); Contract grant sponsor: Ministry of Health; Contract grant sponsor: Ministry of Public Health (former Ministry of Health); Contract grant sponsor: National Institute of Mental Health (NIMH); Contract grant number: U01-MH60220. NR 40 TC 32 Z9 32 U1 1 U2 37 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1091-4269 EI 1520-6394 J9 DEPRESS ANXIETY JI Depress. Anxiety PD JUN PY 2014 VL 31 IS 6 BP 494 EP 505 DI 10.1002/da.22279 PG 12 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA AL3XZ UT WOS:000339066600005 PM 24894802 ER PT J AU Glick, AR Khan, IA Sher, L AF Glick, Amy R. Khan, Imran A. Sher, Leo TI Treatment of Antipsychotic-Induced Sialorrhea SO PSYCHIATRIC ANNALS LA English DT Editorial Material ID CLOZAPINE-INDUCED SIALORRHEA; STRATEGIES C1 [Glick, Amy R.; Sher, Leo] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Khan, Imran A.; Sher, Leo] James J Peters VA Med Ctr, New York, NY USA. RP Glick, AR (reprint author), Icahn Sch Med Mt Sinai, One Gustave L Levy Pl, New York, NY 10029 USA. EM amy.glick@mountsinai.org NR 10 TC 0 Z9 0 U1 0 U2 3 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 EI 1938-2456 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD JUN PY 2014 VL 44 IS 6 BP 267 EP 269 DI 10.3928/00485713-20140609-02 PG 3 WC Psychiatry SC Psychiatry GA AL0PB UT WOS:000338827700002 ER PT J AU Varghese, M Ho, L Wang, J Zhao, W Levine, S Ono, K Mannino, S Pasinetti, GM AF Varghese, Merina Ho, Lap Wang, Jun Zhao, Wei Levine, Samara Ono, Kenjiro Mannino, Salvatore Pasinetti, Giulio Maria TI Green coffee as a novel agent for Alzheimer's disease prevention by attenuating diabetes SO TRANSLATIONAL NEUROSCIENCE LA English DT Article DE Coffee; Alzheimer's disease; Diabetes; Diabetes type 2; Brain; Energy metabolism ID INDUCED INSULIN-RESISTANCE; AMYLOID-BETA LEVELS; COGNITIVE IMPAIRMENT; DECAFFEINATED COFFEE; CHLOROGENIC ACID; MOUSE MODEL; CAFFEINE; MICE; RISK; CONSUMPTION AB Diabetes type 2, caused mainly by insulin resistance, is growing in incidence worldwide. In addition to being a major public health concern, type 2 diabetes is also a risk factor for dementia, including Alzheimer's disease type dementia. Coffee consumption is reported to have protective effects in both diabetes and Alzheimer's disease. We review here the reported beneficial effects of coffee in both disease conditions and the previously identified active ingredients of coffee. Furthermore, we revisit our recent findings of improved glucose utilization in the periphery and in the brain in a mouse model of high-fat diet induced type 2 diabetes after treatment with a decaffeinated green coffee preparation. Overall, consumption of coffee appears to improve diabetes and reduce the risk of dementia, although future studies are required to further identify the active components and the type of coffee that is most effective in addressing these conditions. C1 [Varghese, Merina; Ho, Lap; Wang, Jun; Zhao, Wei; Levine, Samara; Pasinetti, Giulio Maria] Mt Sinai Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA. [Ho, Lap; Wang, Jun; Zhao, Wei; Pasinetti, Giulio Maria] James J Peters Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Bronx, NY 10468 USA. [Ono, Kenjiro] Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol & Aging, Kanazawa, Ishikawa 9209640, Japan. [Mannino, Salvatore] Osped Alzano, Geriatr Output Unit, Bergamo, Italy. RP Varghese, M (reprint author), Mt Sinai Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA. EM giulio.pasinetti@mssm.edu OI Varghese, Merina/0000-0002-1517-3903 NR 44 TC 3 Z9 3 U1 3 U2 20 PU DE GRUYTER OPEN LTD PI WARSAW PA SOLIPSKA 14A-1, 02-482 WARSAW, POLAND SN 2081-3856 EI 2081-6936 J9 TRANSL NEUROSCI JI Transl. Neurosci. PD JUN PY 2014 VL 5 IS 2 BP 111 EP 116 DI 10.2478/s13380-014-0213-y PG 6 WC Neurosciences SC Neurosciences & Neurology GA AK8AV UT WOS:000338650400001 ER PT J AU Scott, JC Pietrzak, RH Southwick, SM Jordan, J Silliker, N Brandt, CA Haskell, SG AF Scott, J. Cobb Pietrzak, Robert H. Southwick, Steven M. Jordan, Jessica Silliker, Norman Brandt, Cynthia A. Haskell, Sally G. TI Military Sexual Trauma Interacts With Combat Exposure to Increase Risk for Posttraumatic Stress Symptomatology in Female Iraq and Afghanistan Veterans SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID MALE VIETNAM VETERANS; MENTAL-HEALTH; GENDER-DIFFERENCES; NATIONAL SAMPLE; WOMEN VETERANS; CHILD-ABUSE; LIFE EVENTS; GULF-WAR; DISORDER; SYMPTOMS AB Objective: Sexual trauma during military service is increasingly recognized as a substantial public health problem and is associated with detrimental effects on veteran mental health. In this study, we examined associations between childhood trauma, military sexual trauma (MST), combat exposure, and military-related posttraumatic stress symptomatology (PTSS) in the Women Veterans Cohort Study (WVCS), a community-based sample of veterans who served in the recent conflicts in Iraq and Afghanistan. Method: From July 2008 to December 2011, 365 female veterans completed a survey that assessed combat exposure, military sexual trauma, military-related PTSS (assessed using the PTSD [posttraumatic stress disorder] Checklist-Military Version), and demographic, life history, and other psychopathology variables. Results: High rates of childhood trauma (59.7%) and MST (sexual assault = 14.7%; sexual harassment = 34.8%) were observed in this sample. A hierarchical regression revealed that active duty status, childhood trauma, combat exposure, and MST were independently associated with increased severity of military-related PTSS (Ps < .05). Moreover, a significant interaction emerged between MST and combat exposure in predicting military-related PTSS (P = .030), suggesting that the relationship between combat exposure and PTSS was altered by MST status. Specifically, under conditions of high combat exposure, female veterans with MST had significantly higher PTSS compared to female veterans without MST. Conclusions: Taken together, results suggest that exposure to multiple traumas during military service may have synergistic effects on posttraumatic stress symptoms in female veterans. Moreover, our findings highlight the importance of prevention efforts to protect female veterans from the detrimental effects of MST, particularly those who are exposed to high levels of combat. (C) Copyright 2014 Physicians Postgraduate Press, Inc. C1 [Scott, J. Cobb; Pietrzak, Robert H.; Southwick, Steven M.; Jordan, Jessica] VA Connecticut Healthcare Syst, Clin Neurosci Div, Natl Ctr Posttraumat Stress Disorder, West Haven, CT USA. [Scott, J. Cobb; Pietrzak, Robert H.; Southwick, Steven M.; Jordan, Jessica] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Scott, J. Cobb] Philadelphia VA Med Ctr, Vet Integrated Serv Network VISN, Mental Illness Res Educ & Clin Ctr MIRECC 4, Philadelphia, PA 19104 USA. [Silliker, Norman; Brandt, Cynthia A.; Haskell, Sally G.] VA Connecticut Healthcare Syst, West Haven, CT USA. [Brandt, Cynthia A.] Dept Emergency Med, New Haven, CT USA. [Brandt, Cynthia A.] Yale Ctr Med Informat, New Haven, CT USA. [Haskell, Sally G.] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA. RP Scott, JC (reprint author), Philadelphia VA Med Ctr, MIRECC 116,3900 Woodland Ave, Philadelphia, PA 19104 USA. EM scott1@mail.med.upenn.edu FU Veterans Administration (VA) Health Services Research and Development Service (HSRD) [DHI07-065]; Clinical Neurosciences Division of the National Center for Posttraumatic Stress Disorder; VA Clinical Science & Research Developmental Award [IK2 CX000772] FX Funding for this study was provided by Veterans Administration (VA) Health Services Research and Development Service (HSR&D) grant #DHI07-065 to Drs Haskell and Brandt. Preparation of this report was also supported in part by the Clinical Neurosciences Division of the National Center for Posttraumatic Stress Disorder and a VA Clinical Science & Research Developmental Award (IK2 CX000772) to Dr Scott. NR 64 TC 12 Z9 12 U1 3 U2 29 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD JUN PY 2014 VL 75 IS 6 BP 637 EP 643 DI 10.4088/JCP.13m08808 PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AK5IO UT WOS:000338458200015 ER PT J AU Kagan, VE Kapralov, AA St Croix, CM Watkins, SC Kisin, ER Kotchey, GP Balasubramanian, K Vlasova, II Yu, J Kim, K Seo, W MallampaIli, RK Star, A Shvedova, AA AF Kagan, Valerian E. Kapralov, Alexandr A. St Croix, Claudette M. Watkins, Simon C. Kisin, Elena R. Kotchey, Gregg P. Balasubramanian, Krishnakumar Vlasova, Irina I. Yu, Jaesok Kim, Kang Seo, Wanji MallampaIli, Rama K. Star, Alexander Shvedova, Anna A. TI Lung Macrophages "Digest" Carbon Nanotubes Using a Superoxide/Peroxynitrite Oxidative Pathway SO ACS NANO LA English DT Article DE single-walled carbon nanotubes; peroxynitrite; biodegradation; lung ID DARK-FIELD MICROSCOPY; IN-VIVO; NITRIC-OXIDE; PULMONARY INFLAMMATION; REACTIVE OXYGEN; PEROXYNITRITE; CELLS; NANOPARTICLES; NANOMATERIALS; NEUTROPHILS AB In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to "digest" carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/NO* -> peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung. C1 [Kagan, Valerian E.; Kapralov, Alexandr A.; Balasubramanian, Krishnakumar; Vlasova, Irina I.] Univ Pittsburgh, Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15260 USA. [MallampaIli, Rama K.] Univ Pittsburgh, Acute Lung Injury Ctr Excellence, Pittsburgh, PA USA. [Kagan, Valerian E.; Kapralov, Alexandr A.; St Croix, Claudette M.; Balasubramanian, Krishnakumar; Vlasova, Irina I.] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA USA. [Watkins, Simon C.] Univ Pittsburgh, Dept Physiol & Cell Biol, Pittsburgh, PA USA. [Kotchey, Gregg P.; Seo, Wanji; Star, Alexander] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Yu, Jaesok; Kim, Kang; MallampaIli, Rama K.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. [MallampaIli, Rama K.] Vet Affairs Pittsburgh Healthcare Syst, Med Specialty Serv Line, Pittsburgh, PA USA. [Shvedova, Anna A.] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Morgantown, WV USA. [Vlasova, Irina I.] Res Inst Physicochem Med, Moscow 119495, Russia. RP Kagan, VE (reprint author), Univ Pittsburgh, Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15260 USA. EM kagan@pitt.edu OI Kapralov, Oleksandr/0000-0002-3006-916X FU National Institute for Occupational Safety and Health (NIOSH) [OH008282]; National Institutes of Health, NIEHS [R01ES019304, U19AI068021, PO1HL114453]; RFBR [12-04-01293]; EPA STAR Graduate Fellowship [FP-91713801] FX This work was supported by the National Institute for Occupational Safety and Health (NIOSH), OH008282, and National Institutes of Health, NIEHS R01ES019304, U19AI068021, PO1HL114453, and RFBR 12-04-01293. G.P.K. acknowledges an EPA STAR Graduate Fellowship, FP-91713801. NR 50 TC 46 Z9 46 U1 0 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD JUN PY 2014 VL 8 IS 6 BP 5610 EP 5621 DI 10.1021/nn406484b PG 12 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AK0FV UT WOS:000338089200025 PM 24871084 ER PT J AU Shore, S Carey, EP Turakhia, MP Jackevicius, CA Cunningham, F Pilote, L Bradley, SM Maddox, TM Grunwald, GK Baron, AE Rumsfeld, JS Varosy, PD Schneider, PM Marzec, LN Ho, PM AF Shore, Supriya Carey, Evan P. Turakhia, Mintu P. Jackevicius, Cynthia A. Cunningham, Fran Pilote, Louise Bradley, Steven M. Maddox, Thomas M. Grunwald, Gary K. Baron, Anna E. Rumsfeld, John S. Varosy, Paul D. Schneider, Preston M. Marzec, Lucas N. Ho, P. Michael TI Adherence to dabigatran therapy and longitudinal patient outcomes: Insights from the Veterans Health Administration SO AMERICAN HEART JOURNAL LA English DT Article ID ATRIAL-FIBRILLATION; ANTITHROMBOTIC TREATMENT; MEDICATION ADHERENCE; CLINICAL-PRACTICE; WARFARIN; ANTICOAGULATION; ETEXILATE; CARE; UNDERTREATMENT; CHALLENGES AB Background Dabigatran is a novel oral anti-coagulant (NOAC) that reduces risk of stroke in patients with non-valvular atrial fibrillation (NVAF). It does not require routine monitoring with laboratory testing which may have an adverse impact on adherence. We aimed to describe adherence to dabigatran in the first year after initiation and assess the association between non-adherence to dabigatran and clinical outcomes in a large integrated healthcare system. Methods We studied a national cohort of 5,376 patients with NVAF, initiated on dabigatran between October-2010 and September-2012 at all Veterans Affairs hospitals. Adherence to dabigatran was calculated as proportion of days covered (PDC) and association between PDC and outcomes was assessed using standard regression techniques. Results Mean age of the study cohort was 71.3 +/- 9.7 years; 98.3% were men and mean CHADS(2) score was 2.4 +/- 1.2 (mean CHA(2)DS(2)VASc score 3.2 +/- 1.4). Median PDC was 94% (IQR 76%-100%; mean PDC 84% +/- 22%) over a median follow-up of 244 days (IQR 140-351). A total of 1,494 (27.8%) patients had a PDC <80% and were classified as non-adherent. After multivariable adjustment, lower adherence was associated with increased risk for combined all-cause mortality and stroke (HR 1.13, 95% CI 1.07-1.19 per 10% decrease in PDC). Adherence to dabigatran was not associated with non-fatal bleeding or myocardial infarction. Conclusions In the year after initiation, adherence to dabigatran for a majority of patients is very good. However, 28% of patients in our cohort had poor adherence. Furthermore, lower adherence to dabigatran was associated with increased adverse outcomes. Concerted efforts are needed to optimize adherence to NOACs. C1 [Shore, Supriya; Carey, Evan P.; Bradley, Steven M.; Maddox, Thomas M.; Grunwald, Gary K.; Rumsfeld, John S.; Varosy, Paul D.; Schneider, Preston M.; Marzec, Lucas N.; Ho, P. Michael] Vet Affairs Eastern Colorado Hlth Care Syst, Denver, CO USA. [Shore, Supriya; Bradley, Steven M.; Maddox, Thomas M.; Rumsfeld, John S.; Varosy, Paul D.; Schneider, Preston M.; Marzec, Lucas N.; Ho, P. Michael] Univ Colorado, Sch Med, Aurora, CO USA. [Shore, Supriya; Carey, Evan P.; Bradley, Steven M.; Maddox, Thomas M.; Rumsfeld, John S.; Varosy, Paul D.; Schneider, Preston M.; Marzec, Lucas N.; Ho, P. Michael] Colorado Cardiovasc Outcomes Res Consortium, Denver, CO USA. [Carey, Evan P.; Grunwald, Gary K.; Baron, Anna E.] Univ Colorado, Sch Publ Hlth, Aurora, CO USA. [Turakhia, Mintu P.] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA. [Turakhia, Mintu P.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Jackevicius, Cynthia A.] Vet Affairs Greater Angeles Hlth Care Syst, Los Angeles, CA USA. [Jackevicius, Cynthia A.] Western Univ Hlth Sci, Pomona, CA USA. [Cunningham, Fran] US Dept Vet Affairs, Pharm Benefits Management Serv, Hines, IL USA. [Cunningham, Fran] Ctr Medicat Safety, Hines, IL USA. [Pilote, Louise] McGill Univ, Ctr Hlth, Montreal, PQ, Canada. RP Ho, PM (reprint author), VA Eastern Colorado Hlth Care Syst, Cardiol Sect, 111B,1055 Clermont St, Denver, CO 80220 USA. EM michael.ho@va.gov FU NHLBI NIH HHS [T32 HL007822] NR 28 TC 49 Z9 49 U1 0 U2 11 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-8703 EI 1097-5330 J9 AM HEART J JI Am. Heart J. PD JUN PY 2014 VL 167 IS 6 BP 810 EP 817 DI 10.1016/j.ahj.2014.03.023 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AK3US UT WOS:000338350800009 PM 24890529 ER PT J AU Sacks, GD Diggs, BS Hadjizacharia, P Green, D Salim, A Malinoski, DJ AF Sacks, Greg D. Diggs, Brian S. Hadjizacharia, Pantelis Green, Donald Salim, Ali Malinoski, Darren J. TI Reducing the rate of catheter-associated bloodstream infections in a surgical intensive care unit using the Institute for Healthcare Improvement central line bundle SO AMERICAN JOURNAL OF SURGERY LA English DT Article DE Catheter-associated line infections; Infection control; Central venous catheters; Quality improvement; Healthcare cost; Checklist ID PRACTICE GUIDELINES; PREVENTION; QUALITY AB BACKGROUND: Central line-associated bloodstream infections (CLABSIs) are a significant source of morbidity and mortality. This study sought to determine whether implementation of the Institute for Healthcare Improvement (IHI) Central Line Bundle would reduce the incidence of CLABSIs. METHODS: The IHI Central Line Bundle was implemented in a surgical intensive care unit. Patient demographics and the rate of CLABSIs per 1,000 catheter days were compared between the pre- and postintervention groups. Contemporaneous infection rates in an adjacent ICU were measured. RESULTS: Baseline demographics were similar between the pre- and postintervention groups. The rate of CLABSIs per catheter days decreased from 19/3,784 to 3/1,870 after implementation of the IHI Bundle (1.60 vs 5.02 CLABSIs per 1,000 catheter days; rate ratio .32 [.08 to .99, P < .05]). There was no significant change in CLABSIs in the control ICU. CONCLUSIONS: Implementation of the IHI Central Line Bundle reduced the incidence of CLABSIs in our SICU by 68%, preventing 12 CLABSIs, 2.5 deaths, and saving $198,600 annually. (C) 2014 Elsevier Inc. All rights reserved. C1 [Sacks, Greg D.] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90024 USA. [Diggs, Brian S.; Malinoski, Darren J.] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA. [Hadjizacharia, Pantelis; Green, Donald] Univ Arizona, Dept Surg, Tucson, AZ USA. [Salim, Ali] Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA. [Malinoski, Darren J.] Portland VA Med Ctr, Sect Surg Crit Care, Portland, OR USA. RP Malinoski, DJ (reprint author), Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA. EM darren.malinoski@va.gov NR 24 TC 15 Z9 16 U1 0 U2 8 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 EI 1879-1883 J9 AM J SURG JI Am. J. Surg. PD JUN PY 2014 VL 207 IS 6 BP 817 EP 823 DI 10.1016/j.amjsurg.2013.08.041 PG 7 WC Surgery SC Surgery GA AK5BY UT WOS:000338440100003 PM 24576582 ER PT J AU Donnelly, J Wang, H Locke, J Mannon, R Baddley, J AF Donnelly, J. Wang, H. Locke, J. Mannon, R. Baddley, J. TI Healthcare Facility-Associated Clostridium difficile Infection in Solid Organ Transplant Recipients SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT World Transplant Congress CY JUL 26-31, 2014 CL San Francisco, CA C1 [Donnelly, J.; Wang, H.] Univ Alabama Birmingham, Dept Emergency Med, Birmingham, AL USA. [Locke, J.] Univ Alabama Birmingham, Dept Surg, Birmingham, AL 35294 USA. [Mannon, R.; Baddley, J.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Baddley, J.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2014 VL 14 SU 3 MA D2397 BP 772 EP 772 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA AJ9LU UT WOS:000338033303405 ER PT J AU Hebert, PL Liu, CF Wong, ES Hernandez, SE Batten, A Lo, S Lemon, JM Conrad, DA Grembowski, D Nelson, K Fihn, SD AF Hebert, Paul L. Liu, Chuan-Fen Wong, Edwin S. Hernandez, Susan E. Batten, Adam Lo, Sophie Lemon, Jaclyn M. Conrad, Douglas A. Grembowski, David Nelson, Karin Fihn, Stephan D. TI Patient-Centered Medical Home Initiative Produced Modest Economic Results For Veterans Health Administration, 2010-12 SO HEALTH AFFAIRS LA English DT Article ID PRIMARY-CARE; COST SAVINGS; GROWTH; ACCESS AB In 2010 the Veterans Health Administration (VHA) began a nationwide initiative called Patient Aligned Care Teams (PACT) that reorganized care at all VHA primary care clinics in accordance with the patient-centered medical home model. We analyzed data for fiscal years 2003-12 to assess how trends in health care use and costs changed after the implementation of PACT. We found that PACT was associated with modest increases in primary care visits and with modest decreases in both hospitalizations for ambulatory care-sensitive conditions and outpatient visits with mental health specialists. We estimated that these changes avoided $596 million in costs, compared to the investment in PACT of $774 million, for a potential net loss of $178 million in the study period. Although PACT has not generated a positive return, it is still maturing, and trends in costs and use are favorable. Adopting patient-centered care does not appear to have been a major financial risk for the VHA. C1 [Hebert, Paul L.] VA Puget Sound Hlth Care Syst, Vet Affairs VA Hlth Serv Res & Dev Ctr Vet Ctr, Value Driven Hlth, Seattle, WA 98108 USA. [Hebert, Paul L.; Liu, Chuan-Fen; Hernandez, Susan E.] Univ Washington, Dept Hlth Serv, Sch Publ Hlth, Seattle, WA 98195 USA. [Liu, Chuan-Fen; Wong, Edwin S.; Batten, Adam; Nelson, Karin] Value Driven Hlth, VA Hlth Serv Res & Dev Ctr Vet Ctr, Seattle, WA USA. [Lo, Sophie] Vet Hlth Adm Off Analyt & Business Intelligence, Bedford, MA USA. [Lemon, Jaclyn M.] Univ Washington, Sch Med, Seattle, WA 98195 USA. [Conrad, Douglas A.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA. [Grembowski, David] Univ Washington, Seattle, WA 98195 USA. [Nelson, Karin; Fihn, Stephan D.] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA. [Fihn, Stephan D.] VA Puget Sound Hlth Care Syst, VHA Off Analyt & Business Intelligence, Seattle, WA USA. RP Hebert, PL (reprint author), VA Puget Sound Hlth Care Syst, Vet Affairs VA Hlth Serv Res & Dev Ctr Vet Ctr, Value Driven Hlth, Seattle, WA 98108 USA. EM paul.hebert2@va.gov FU Veterans Health Administration (VHA) Patient Centered Medical Home Demonstration Laboratory Coordination Center [XVA-61-041]; VHA Health Services Research and Development Career Development Award [CDA 13-024] FX This research was presented at the Society of General Internal Medicine Annual Meeting, Denver, Colorado, April 23, 2013; and the AcademyHealth Annual Research Meeting, Baltimore, Maryland, June 23, 2013. This work was funded by the Veterans Health Administration (VHA) Patient Centered Medical Home Demonstration Laboratory Coordination Center (Grant No. XVA-61-041). Edwin Wong is supported by a VHA Health Services Research and Development Career Development Award (Grant No. CDA 13-024). The views expressed herein are those of the authors and do not necessary represent the views of the Department of Veterans Affairs or other affiliated institutions. NR 21 TC 13 Z9 13 U1 1 U2 3 PU PROJECT HOPE PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA SN 0278-2715 J9 HEALTH AFFAIR JI Health Aff. PD JUN PY 2014 VL 33 IS 6 BP 980 EP 987 DI 10.1377/hlthaff.2013.0893 PG 8 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA AK1PL UT WOS:000338187200009 PM 24889947 ER PT J AU Walling, AM Dy, SM AF Walling, Anne M. Dy, Sydney M. TI The Importance of a Comprehensive, Patient-Centered Approach to End-of-Life Care SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material ID DISCUSSIONS; PREFERENCES; OUTCOMES C1 [Walling, Anne M.] Univ Calif Los Angeles, David Geffen Sch Med, Div Gen Internal Med & Hlth Serv Res, Los Angeles, CA 90095 USA. [Walling, Anne M.] Greater Los Angeles Vet Affairs Healthcare Syst, Los Angeles, CA USA. [Dy, Sydney M.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA. [Dy, Sydney M.] Johns Hopkins Kimmel Canc Ctr, Harry J Duffey Family Pain & Palliat Care Program, Baltimore, MD USA. RP Dy, SM (reprint author), Rm 609,624 N Broadway, Baltimore, MD 21205 USA. EM sdy@jhsph.edu FU NCATS NIH HHS [KL2 TR000122, UL1 TR000124, KL2TR000122] NR 14 TC 1 Z9 1 U1 3 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2014 VL 29 IS 6 BP 822 EP 823 DI 10.1007/s11606-013-2757-x PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VS UT WOS:000338206600002 PM 24420868 ER PT J AU Bailey, FA Williams, BR Woodby, LL Goode, PS Redden, DT Houston, TK Granstaff, US Johnson, TM Pennypacker, LC Haddock, KS Painter, JM Spencer, JM Hartney, T Burgio, KL AF Bailey, F. Amos Williams, Beverly R. Woodby, Lesa L. Goode, Patricia S. Redden, David T. Houston, Thomas K. Granstaff, U. Shanette Johnson, Theodore M., II Pennypacker, Leslye C. Haddock, K. Sue Painter, John M. Spencer, Jessie M. Hartney, Thomas Burgio, Kathryn L. TI Intervention to Improve Care at Life's End in Inpatient Settings: The BEACON Trial SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE palliative care; end-of-life care; palliative medicine; hospice; inpatient ID ILL CANCER-PATIENTS; SMALL-SAMPLE ADJUSTMENTS; PALLIATIVE CARE; OF-LIFE; INTENSIVE-CARE; PAIN MANAGEMENT; HOSPICE CARE; LAST HOURS; DEATH; OPPORTUNITIES AB BACKGROUND: Widespread implementation of palliative care treatment plans could reduce suffering in the last days of life by adopting best practices of traditionally home-based hospice care in inpatient settings. OBJECTIVE: To evaluate the effectiveness of a multi-modal intervention strategy to improve processes of end-of-life care in inpatient settings. DESIGN: Implementation trial with an intervention staggered across hospitals using a multiple-baseline, stepped wedge design. PARTICIPANTS: Six Veterans Affairs Medical Centers (VAMCs). INTERVENTION: Staff training was targeted to all hospital providers and focused on identifying actively dying patients and implementing best practices from home-based hospice care, supported with an electronic order set and paper-based educational tools. MAIN MEASURES: Several processes of care were identified as quality endpoints for end-of-life care (last 7 days) and abstracted from electronic medical records of veterans who died before or after intervention (n=6,066). Primary endpoints were proportion with an order for opioid pain medication at time of death, do-not-resuscitate order, location of death, nasogastric tube, intravenous line infusing, and physical restraints. Secondary endpoints were administration of opioids, order/administration of antipsychotics, benzodiazepines, and scopolamine (for death rattle); sublingual administration; advance directives; palliative care consultations; and pastoral care services. Generalized estimating equations were conducted adjusting for longitudinal trends. KEY RESULTS: Significant intervention effects were observed for orders for opioid pain medication (OR: 1.39), antipsychotic medications (OR: 1.98), benzodiazepines (OR: 1.39), death rattle medications (OR: 2.77), sublingual administration (OR: 4.12), nasogastric tubes (OR: 0.71), and advance directives (OR: 1.47). Intervention effects were not significant for location of death, do-not-resuscitate orders, intravenous lines, or restraints. CONCLUSIONS: This broadly targeted intervention strategy led to modest but statistically significant changes in several processes of care, indicating its potential for widespread dissemination to improve end-of-life care for thousands of patients who die each year in inpatient settings. (C) Society of General Internal Medicine 2014 C1 [Bailey, F. Amos; Williams, Beverly R.; Woodby, Lesa L.; Goode, Patricia S.; Redden, David T.; Granstaff, U. Shanette; Burgio, Kathryn L.] Birmingham Atlanta Geriatr Res Educ & Clin Ctr GR, Dept Vet Affairs, Birmingham, AL USA. [Bailey, F. Amos; Williams, Beverly R.; Woodby, Lesa L.; Goode, Patricia S.; Redden, David T.; Granstaff, U. Shanette; Burgio, Kathryn L.] Univ Alabama Birmingham, Birmingham, AL USA. [Houston, Thomas K.] US Dept Vet Affairs, VA eHlth Qual Enhancement Res Initiat, Bedford, MA USA. [Houston, Thomas K.] Univ Massachusetts Med Sch, Worcester, MA USA. [Johnson, Theodore M., II] Birmingham Atlanta Geriatr Res Educ & Clin Ctr GR, Decatur, GA USA. [Johnson, Theodore M., II] Emory Univ, Atlanta, GA 30322 USA. [Pennypacker, Leslye C.] Malcom Randall VA Med Ctr, Gainesville, FL USA. [Haddock, K. Sue] William Jennings Bryan Dorn VA Med Ctr, Columbia, SC USA. [Painter, John M.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Spencer, Jessie M.] GV Sonny Montgomery VA Med Ctr, Jackson, MS USA. [Hartney, Thomas] Charlie Norwood VA Med Ctr, Augusta, GA USA. RP Burgio, KL (reprint author), Birmingham VA Med Ctr, Birmingham Atlanta Geriatr Res Educ & Clin Ctr, 11G,700 South 19th St, Birmingham, AL 35233 USA. EM kburgio@uabmc.edu FU Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Health Services Research and Development Service [IIR 03-126] FX This research was supported by a Merit Review grant from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Health Services Research and Development Service (IIR 03-126 "Intervention to Improve Care at Life's End in VA Medical Centers;" PI: KL Burgio, Co-PI: FA Bailey). The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript. NR 62 TC 15 Z9 15 U1 1 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2014 VL 29 IS 6 BP 836 EP 843 DI 10.1007/s11606-013-2724-6 PG 8 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VS UT WOS:000338206600008 PM 24449032 ER PT J AU Wald, HL Leykum, LK Mattison, MLP Vasilevskis, EE Meltzer, DO AF Wald, Heidi L. Leykum, Luci K. Mattison, Melissa L. P. Vasilevskis, Eduard E. Meltzer, David O. TI Road Map to a Patient-Centered Research Agenda at the Intersection of Hospital Medicine and Geriatric Medicine SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE geriatrics; hospitals; hospitalists; patient-centered care; research ID OLDER PATIENTS; CARE; ADULTS AB As the United States ages, the patient population in acute care hospitals is increasingly older and more medically complex. Despite evidence of a high burden of disease, high costs, and often poor outcomes of care, there is limited understanding of the presentation, diagnostic strategies, and management of acute illness in older adults. In this paper, we present a strategy for the development of a research agenda at the intersection of hospital and geriatric medicine. This approach is informed by the Patient-Centered Outcomes Research Institute (PCORI) framework for identification and prioritization of research areas, emphasizing input from patients and caregivers. The framework's four components are: 1) Topic generation, 2) Gap Analysis in Systematic Review, 3) Value of information (VOI) analysis, and 4) Peer Review. An inclusive process for topic generation requiring the systematic engagement of multiple stakeholders, especially patients, is emphasized. In subsequent steps, researchers and stakeholders prioritize research topics in order to identify areas that optimize patient-centeredness, population impact, impact on clinical decision making, ease of implementation, and durability. Finally, next steps for dissemination of the research agenda and evaluation of the impact of the patient-centered research prioritization process are described. (C) Society of General Internal Medicine 2014 C1 [Wald, Heidi L.] Univ Colorado Sch Med, Div Hlth Care Policy & Res, Aurora, CO USA. [Leykum, Luci K.] Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. [Mattison, Melissa L. P.] Beth Israel Deaconess Med Ctr, Boston, MA USA. [Mattison, Melissa L. P.] Harvard Univ, Sch Med, Boston, MA USA. [Vasilevskis, Eduard E.] Vanderbilt Univ, Div Gen Internal Med & Publ Hlth, Sect Hosp Med, Nashville, TN 37235 USA. [Vasilevskis, Eduard E.] Vanderbilt Univ, Ctr Qual Aging, Nashville, TN 37235 USA. [Vasilevskis, Eduard E.] GRECC, Nashville, TN USA. [Meltzer, David O.] Univ Chicago, Chicago, IL 60637 USA. RP Wald, HL (reprint author), Div Hlth Care Policy & Res, Dept Med, Campus Box F480 13199 E Moniview Blvd,Suite 400, Aurora, CO 80024 USA. EM Heidi.wald@ucdenver.edu RI Meltzer, David/C-2926-2009 OI Meltzer, David/0000-0003-2790-7393 FU American Association of Instructors of Medicine/Association of Specialty Providers; John A. Hartford Foundation; Paul Beeson Career Development Award in Aging (NIA) [5 K23 AG034544]; Rx Foundation; Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service [REA 05-129, CDA 07-022]; South Texas Veterans Health Care System; National Institute On Aging of the National Institutes of Health [K23AG040157]; Veterans Affairs Clinical Research Center of Excellence; Geriatric Research, Education and Clinical Center (GRECC) FX This work was supported by the American Association of Instructors of Medicine/Association of Specialty Providers, and the John A. Hartford Foundation. Dr. Wald is supported by a Paul Beeson Career Development Award in Aging (NIA 5 K23 AG034544). Dr. Mattison acknowledges the support of Rx Foundation. This work was also supported by the Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service (REA 05-129, CDA 07-022). Investigator salary support (to Dr. Leykum) is provided through this funding, and through the South Texas Veterans Health Care System. Dr. Vasilevskis was supported by the National Institute On Aging of the National Institutes of Health (K23AG040157) and the Veterans Affairs Clinical Research Center of Excellence, and the Geriatric Research, Education and Clinical Center (GRECC). NR 23 TC 5 Z9 5 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2014 VL 29 IS 6 BP 926 EP 931 DI 10.1007/s11606-014-2777-1 PG 6 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VS UT WOS:000338206600023 PM 24557516 ER PT J AU Arbaje, AI Kansagara, DL Salanitro, AH Englander, HL Kripalani, S Jencks, SF Lindquist, LA AF Arbaje, Alicia I. Kansagara, Devan L. Salanitro, Amanda H. Englander, Honora L. Kripalani, Sunil Jencks, Stephen F. Lindquist, Lee A. TI Regardless of Age: Incorporating Principles from Geriatric Medicine to Improve Care Transitions for Patients with Complex Needs SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE care transitions; geriatrics; utilization; healthcare delivery; vulnerable populations ID CONGESTIVE-HEART-FAILURE; OLDER-ADULTS; HOSPITAL READMISSION; RANDOMIZED-TRIAL; RISK; INTERVENTION; CAREGIVERS; SETTINGS; REHOSPITALIZATIONS; DEMENTIA AB With its focus on holistic approaches to patient care, caregiver support, and delivery system redesign, geriatrics has advanced our understanding of optimal care during transitions. This article provides a framework for incorporating geriatrics principles into care transition activities by discussing the following elements: (1) identifying factors that make transitions more complex, (2) engaging care "receivers" and tailoring home care to meet patient needs, (3) building "recovery plans" into transitional care, (4) predicting and avoiding preventable readmissions, and (5) adopting a palliative approach, when appropriate, that optimizes patient and family goals of care. The article concludes with a discussion of practical aspects of designing, implementing, and evaluating care transitions programs for those with complex care needs, as well as implications for public policy. (C) Society of General Internal Medicine 2014 C1 [Arbaje, Alicia I.] Johns Hopkins Univ, Dept Med, Div Geriatr Med & Gerontol, Baltimore, MD 21224 USA. [Kansagara, Devan L.] Oregon Hlth & Sci Univ, Sect Gen Internal Med, Portland VA Med Ctr, Portland, OR 97201 USA. [Salanitro, Amanda H.] Vanderbilt Univ Sch Med, Nashville, TN USA. [Englander, Honora L.] Oregon Hlth & Sci Univ, Div Hosp Med, Portland, OR 97201 USA. [Kripalani, Sunil] Vanderbilt Univ Sch Med, Div Gen Internal Med & Publ Hlth, Sect Hosp Med, Nashville, TN USA. [Jencks, Stephen F.] Healthcare Safety & Qual, Baltimore, MD USA. [Lindquist, Lee A.] Northwestern Univ Feinberg Sch Med, Sect Gen Internal Med & Geriatr, Dept Med, Chicago, IL USA. RP Arbaje, AI (reprint author), Johns Hopkins Univ, Dept Med, Div Geriatr Med & Gerontol, Mason F Lord Bldg,Ctr Tower,5200 Eastern Ave,7th, Baltimore, MD 21224 USA. EM aarbaje@jhmi.edu FU Association of Specialty Professors FX The Association of Specialty Professors provided funding for the conceptualization of priority areas for publication, of which this manuscript is one. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government. NR 49 TC 4 Z9 4 U1 3 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2014 VL 29 IS 6 BP 932 EP 939 DI 10.1007/s11606-013-2729-1 PG 8 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VS UT WOS:000338206600024 PM 24557511 ER PT J AU Chiovaro, JC Gaggar, A AF Chiovaro, Joseph C. Gaggar, Anuj TI Crystalline Bone Marrow in Systemic Oxalosis SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material ID PRIMARY HYPEROXALURIA C1 [Chiovaro, Joseph C.] Portland VA Med Ctr, Portland, OR USA. [Chiovaro, Joseph C.] Oregon Hlth & Sci Univ, Portland, OR 97239 USA. [Gaggar, Anuj] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Chiovaro, JC (reprint author), Oregon Hlth & Sci Univ, Portland VA Med Ctr, Dept Med, 3710 Southwest US Vet Hosp Rd, Portland, OR 97239 USA. EM jchiovaro@gmail.com NR 3 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2014 VL 29 IS 6 BP 961 EP 961 DI 10.1007/s11606-013-2618-7 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VS UT WOS:000338206600028 PM 24078429 ER PT J AU Cardo, LF Coto, E Ribacoba, R Mata, IF Moris, G Menendez, M Alvarez, V AF Cardo, Lucia F. Coto, Eliecer Ribacoba, Rene Mata, Ignacio F. Moris, German Menendez, Manuel Alvarez, Victoria TI The screening of the 3 ' UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson's disease SO JOURNAL OF HUMAN GENETICS LA English DT Article DE DNA polymorphisms; genetic risk; LRRK2 gene; microRNAs; Parkinson's disease ID MUTATION; VARIANTS; BRAIN; SNCA; GENE AB Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common genetic determinants of familial and sporadic Parkinson's disease (PD). Most of the mutational screenings analyzed the exon-coding sequence. Our aim was to determine whether LRRK2 3' untranslated region (UTR) variants were associated with the risk of developing PD in a large cohort of patients (n = 743) and controls (n = 523) from Spain. We identified a total of 12 3'UTR variants (two new). Single-nucleotide polymorphism (SNP) rs66737902 C allele was overrepresented in patients (P = 0.005; odds ratio = 1.47). This SNP was in linkage disequilibrium with the p.R1441G mutation, but the association remained significant among mutation-negative cases. We found a significant lower level of the LRRK2 transcript in the Substantia nigra (SN) of PD postmortem donors (n = 9) who were rs66737902 C carriers (P = 0.01). This SNP was predicted to affect a binding site for miR-138-2-3p. We showed that this microRNA was expressed in all the SN samples. In conclusion, we found a significant association between SNP rs66737902 and the risk of developing PD. This effect on PD risk could be explained by differences in LRRK2 transcript levels between the two alleles. C1 [Cardo, Lucia F.; Coto, Eliecer; Alvarez, Victoria] Hosp Univ Cent Asturias, Genet Mol Lab Med, Oviedo 33006, Spain. [Coto, Eliecer] Univ Oviedo, Dept Med, Oviedo, Spain. [Ribacoba, Rene; Moris, German; Menendez, Manuel] Hosp Univ Cent Asturias & Alvarez Buylla Mieres, Asturias, Spain. [Mata, Ignacio F.] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA. [Mata, Ignacio F.] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA. RP Alvarez, V (reprint author), Hosp Univ Cent Asturias, Genet Mol Lab Med, Oviedo 33006, Spain. EM victoria.alvarez@sespa.princast.es FU 'Fundacion Parkinson Asturias'; 'Obra Social Cajastur'; Spanish 'Fondo de Investigaciones Sanitarias-Fondos FEDER' European Union [FIS 11/0093]; FICYT-Principado de Asturias FX We thank Dr Claire Troakes and the London Neurodegenerative Diseases Brain Bank for supplying all post mortem brain samples. We also thank the 'Fundacion Parkinson Asturias' and 'Obra Social Cajastur' for their support. This work was supported by grants from the Spanish 'Fondo de Investigaciones Sanitarias-Fondos FEDER' European Union (FIS 11/0093). LFC is a predoctoral fellowship from FICYT-Principado de Asturias. NR 17 TC 2 Z9 2 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1434-5161 EI 1435-232X J9 J HUM GENET JI J. Hum. Genet. PD JUN PY 2014 VL 59 IS 6 BP 346 EP 348 DI 10.1038/jhg.2014.26 PG 3 WC Genetics & Heredity SC Genetics & Heredity GA AK1PC UT WOS:000338186000010 PM 24758914 ER PT J AU Joseph, NT Kamarck, TW Muldoon, MF Manuck, SB AF Joseph, Nataria Tennille Kamarck, Thomas W. Muldoon, Matthew F. Manuck, Stephen B. TI Daily Marital Interaction Quality and Carotid Artery Intima-Medial Thickness in Healthy Middle-Aged Adults SO PSYCHOSOMATIC MEDICINE LA English DT Article DE marital quality; marital interaction; ecological momentary assessment; intima-media thickness; cardiovascular disease ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; DAILY-LIFE; WOMEN; RISK; ASSOCIATION; STRESS; SAMPLE; PROGRESSION AB Objective: To examine the association between marital interaction quality during daily life and subclinical cardiovascular disease (CVD). Studies have shown that marital status and quality of marriage are associated with cardiovascular health. However, little is known about the role of marital interaction quality during daily life in contributing to these effects. Methods: The sample consisted of 281 healthy, employed middle-aged adults who were married or living with a partner in a marital-like relationship (mean age = 42.0 years, 88% white, 52% men). Marital interaction quality was assessed using hourly real-time ecological momentary assessments for 4 days, with participants rating their current or recent partner interactions on positive and negative characteristics (e. g., agreeableness and conflict). Carotid artery intima-medial thickness (IMT) was assessed using ultrasound imaging. Results: Adjusting for demographics, positive marital interaction was inversely associated with IMT (b = -0.02, F(1,275) = 9.18, p = .002), and negative marital interaction was positively associated with IMT (b = 0.02 F(1,275) = 10.29, p = .001). These associations were not accounted for by behavioral and biological CVD risk factors and were consistent across age, sex, race, and education. The associations were also independent of marital interaction frequency, nonmarital social interaction quality, and personality factors. Global reports of marital quality, in contrast, were not associated with IMT. Conclusions: Marital quality as measured during real-time interactions between partners was associated with subclinical CVD in healthy middle-aged adults. This study supports the use of real-time social interaction assessment for characterizing links between social relationships and cardiovascular health. C1 [Joseph, Nataria Tennille] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA. [Kamarck, Thomas W.] Univ Pittsburgh, Dept Psychiat & Psychol, Pittsburgh, PA USA. [Muldoon, Matthew F.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. [Manuck, Stephen B.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA. RP Joseph, NT (reprint author), VA Greater Los Angeles Healthcare Syst, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM nataria.joseph@va.gov FU National Institutes of Health [P01 HL040962, T32 HL007560]; VA Office of Academic Affiliations' Women's Health Fellowship Program FX This research was supported by National Institutes of Health Grants P01 HL040962 awarded to Drs. Manuck, Kamarck, and Muldoon and T32 HL007560 (fellowship) awarded to Dr. Joseph. Dr. Joseph is currently supported by the VA Office of Academic Affiliations' Women's Health Fellowship Program. The authors have no conflicts of interest to disclose. NR 49 TC 11 Z9 11 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0033-3174 EI 1534-7796 J9 PSYCHOSOM MED JI Psychosom. Med. PD JUN PY 2014 VL 76 IS 5 BP 347 EP 354 DI 10.1097/PSY.0000000000000071 PG 8 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA AK0TQ UT WOS:000338128800004 PM 24915293 ER PT J AU Bera, A Das, F Ghosh-Choudhury, N Li, XN Pal, S Gorin, Y Kasinath, BS Abboud, HE Choudhury, GG AF Bera, Amit Das, Falguni Ghosh-Choudhury, Nandini Li, Xiaonan Pal, Sanjay Gorin, Yves Kasinath, Balakuntalam S. Abboud, Hanna E. Choudhury, Goutam Ghosh TI A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY LA English DT Article DE Akt kinase; cell proliferation; MAP kinase; receptor tyrosine kinase; renal physiology ID METANEPHRIC MESENCHYMAL CELLS; ACTIVATED PROTEIN-KINASE; INDUCED DNA-SYNTHESIS; GROWTH-FACTOR; PHOSPHATIDYLINOSITOL 3-KINASE; CYCLIN D1; TRANSGENIC MICE; EXPRESSION; RECEPTOR; GLOMERULONEPHRITIS AB Platelet-derived growth factor BB and its receptor (PDGFR beta) play a pivotal role in the development of renal glomerular mesangial cells. Their roles in increased mesangial cell proliferation during mesangioproliferative glomerulonephritis have long been noted, but the operating logic of signaling mechanisms regulating these changes remains poorly understood. We examined the role of a recently identified MAPK, Erk5, in this process. PDGF increased the activating phosphorylation of Erk5 and tyrosine phosphorylation of proteins in a time-dependent manner. A pharmacologic inhibitor of Erk5, XMD8-92, abrogated PDGF-induced DNA synthesis and mesangial cell proliferation. Similarly, expression of dominant negative Erk5 or siRNAs against Erk5 blocked PDGF-stimulated DNA synthesis and proliferation. Inhibition of Erk5 attenuated expression of cyclin D1 mRNA and protein, resulting in suppression of CDK4-mediated phosphorylation of the tumor suppressor protein pRb. Expression of cyclin D1 or CDK4 prevented the dominant negative Erk5-or siErk5 mediated inhibition of DNA synthesis and mesangial cell proliferation induced by PDGF. We have previously shown that phosphatidylinositol 3-kinase (PI3-kinase) contributes to PDGF-induced proliferation of mesangial cells. Inhibition of PI3-kinase blocked PDGF-induced phosphorylation of Erk5. Since PI3-kinase acts through Akt, we determined the role of Erk5 on Akt phosphorylation. XMD8-92, dominant negative Erk5, and siErk5 inhibited phosphorylation of Akt by PDGF. Interestingly, we found inhibition of PDGF-induced Erk5 phosphorylation by a pharmacological inhibitor of Akt kinase and kinase dead Akt in mesangial cells. Thus our data unfold the presence of a positive feedback microcircuit between Erk5 and Akt downstream of PI3-kinase nodal point for PDGF-induced mesangial cell proliferation. C1 [Ghosh-Choudhury, Nandini; Kasinath, Balakuntalam S.; Abboud, Hanna E.; Choudhury, Goutam Ghosh] South Texas Vet Hlth Care Syst, Vet Adm Res Serv, San Antonio, TX USA. [Ghosh-Choudhury, Nandini] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Bera, Amit; Das, Falguni; Li, Xiaonan; Pal, Sanjay; Gorin, Yves; Kasinath, Balakuntalam S.; Abboud, Hanna E.; Choudhury, Goutam Ghosh] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Choudhury, Goutam Ghosh] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX USA. RP Choudhury, GG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. EM choudhuryg@uthscsa.edu FU Veterans Affairs Service Merit Review [5I01BX000926]; National Institute of Diabetes and Digestive and Kidney Diseases [RO1-DK-50190]; National Institutes of Health and Veterans Affairs Research Service grants; Cancer Therapy and Research Center at San Antonio; Veterans Affairs Research Service Merit Review grant; Veterans Affairs Senior Research Career Scientist Award FX The results described in this manuscript are the work supported by Veterans Affairs Service Merit Review Grant 5I01BX000926 and National Institute of Diabetes and Digestive and Kidney Diseases Grant RO1-DK-50190 (to G. G. Choudhury). G. G. Choudhury is a recipient of Veterans Affairs Senior Research Career Scientist Award. B. S. Kasinath, Y. Gorin, and H. E. Abboud are supported by National Institutes of Health and Veterans Affairs Research Service grants (B. S. Kasinath and H. E. Abboud). N. Ghosh-Choudhury is supported by Veterans Affairs Research Service Merit Review grant and a pilot grant from Cancer Therapy and Research Center at San Antonio. NR 45 TC 7 Z9 7 U1 0 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6143 EI 1522-1563 J9 AM J PHYSIOL-CELL PH JI Am. J. Physiol.-Cell Physiol. PD JUN PY 2014 VL 306 IS 11 BP C1089 EP C1100 DI 10.1152/ajpcell.00387.2013 PG 12 WC Cell Biology; Physiology SC Cell Biology; Physiology GA AJ7SL UT WOS:000337897300012 PM 24740537 ER PT J AU Huang, LW Lipschutz, JH AF Huang, Liwei Lipschutz, Joshua H. TI Cilia and Polycystic Kidney Disease, Kith and Kin SO BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS LA English DT Review DE polycystic kidney disease; cilia; planar cell polarity; exocyst ID PLANAR CELL POLARITY; LEFT-RIGHT AXIS; SMOOTH-MUSCLE-CELLS; INTRAFLAGELLAR TRANSPORT; EPITHELIAL-CELLS; CYSTIC KIDNEY; RENAL CILIA; INTRACELLULAR CALCIUM; PRIMARY CILIOGENESIS; MEMBRANE-PROTEIN AB In the past decade, cilia have been found to play important roles in renal cystogenesis. Many genes, such as PKD1 and PKD2 which, when mutated, cause autosomal dominant polycystic kidney disease (ADPKD), have been found to localize to primary cilia. The cilium functions as a sensor to transmit extracellular signals into the cell. Abnormal cilia structure and function are associated with the development of polyscystic kidney disease (PKD). Cilia assembly includes centriole migration to the apical surface of the cell, ciliary vesicle docking and fusion with the cell membrane at the intended site of cilium outgrowth, and microtubule growth from the basal body. This review summarizes the most recent advances in cilia and PKD research, with special emphasis on the mechanisms of cytoplasmic and intraciliary protein transport during ciliogenesis. (C) 2014 Wiley Periodicals, Inc. C1 Eastern Virginia Med Sch, Dept Med, Norfolk, VA 23501 USA. Philadelphia Vet Affairs Med Ctr, Dept Med, Philadelphia, PA USA. Univ Penn, Dept Med, Philadelphia, PA 19104 USA. RP Huang, LW (reprint author), Lewis Hall Rm 2124,740 W Olney Rd, Norfolk, VA 23501 USA. EM huangle@evms.edu FU Veterans Affairs (Merit Award); NIH [DK093625, 5P30 DK047757-18] FX Supported by a grant from the Veterans Affairs (Merit Award to J.H.L.), and NIH (DK093625 to L. H., and 5P30 DK047757-18 pilot award to J.H.L.). NR 96 TC 3 Z9 4 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-975X EI 1542-9768 J9 BIRTH DEFECTS RES C JI Birth Defects Res. Part C-Embryo Today-Rev. PD JUN PY 2014 VL 102 IS 2 BP 174 EP 185 DI 10.1002/bdrc.21066 PG 12 WC Developmental Biology; Reproductive Biology SC Developmental Biology; Reproductive Biology GA AJ8PG UT WOS:000337967700005 PM 24898006 ER PT J AU Clark, DG Kapur, P Geldmacher, DS Brockington, JC Harrell, L DeRamus, TP Blanton, PD Lokken, K Nicholas, AP Marson, DC AF Clark, D. G. Kapur, P. Geldmacher, D. S. Brockington, J. C. Harrell, L. DeRamus, T. P. Blanton, P. D. Lokken, K. Nicholas, A. P. Marson, D. C. TI Latent information in fluency lists predicts functional decline in persons at risk for Alzheimer disease SO CORTEX LA English DT Article DE Alzheimer's disease; Cognitive neuropsychology; Dementia; MCI (mild cognitive impairment); Machine learning; Random forests ID MILD COGNITIVE IMPAIRMENT; VERBAL FLUENCY; FINANCIAL ABILITIES; CONVERSION; DEMENTIA; DIAGNOSIS; CAPACITY; INFERIOR; ATROPHY AB Objective: We constructed random forest classifiers employing either the traditional method of scoring semantic fluency word lists or new methods. These classifiers were then compared in terms of their ability to diagnose Alzheimer disease (AD) or to prognosticate among individuals along the continuum from cognitively normal (CN) through mild cognitive impairment (MCI) to AD. Method: Semantic fluency lists from 44 cognitively normal elderly individuals, 80 MCI patients, and 41 AD patients were transcribed into electronic text files and scored by four methods: traditional raw scores, clustering and switching scores, "generalized" versions of clustering and switching, and a method based on independent components analysis (ICA). Random forest classifiers based on raw scores were compared to "augmented" classifiers that incorporated newer scoring methods. Outcome variables included AD diagnosis at baseline, MCI conversion, increase in Clinical Dementia Rating-Sum of Boxes (CDR-SOB) score, or decrease in Financial Capacity Instrument (FCI) score. Receiver operating characteristic (ROC) curves were constructed for each classifier and the area under the curve (AUC) was calculated. We compared AUC between raw and augmented classifiers using Delong's test and assessed validity and reliability of the augmented classifier. Results: Augmented classifiers outperformed classifiers based on raw scores for the outcome measures AD diagnosis (AUC .97 vs .95), MCI conversion (AUC .91 vs .77), CDR-SOB increase (AUC .90 vs .79), and FCI decrease (AUC .89 vs .72). Measures of validity and stability over time support the use of the method. Conclusion: Latent information in semantic fluency word lists is useful for predicting cognitive and functional decline among elderly individuals at increased risk for developing AD. Modem machine learning methods may incorporate latent information to enhance the diagnostic value of semantic fluency raw scores. These methods could yield information valuable for patient care and clinical trial design with a relatively small investment of time and money. Published by Elsevier Ltd. C1 [Clark, D. G.; Blanton, P. D.; Lokken, K.; Nicholas, A. P.] Birmingham VA Med Ctr, Birmingham, AL 35233 USA. [Clark, D. G.; Geldmacher, D. S.; Brockington, J. C.; Harrell, L.; Nicholas, A. P.; Marson, D. C.] Univ Alabama Birmingham, Dept Neurol, Birmingham, AL USA. [Kapur, P.] Georgia Hlth Sci Univ, Dept Biomed Sci, Augusta, GA USA. [DeRamus, T. P.] Univ Alabama Birmingham, Dept Psychol & Behav Neurosci, Birmingham, AL USA. RP Clark, DG (reprint author), 1720,7th Ave South,SC 620C, Birmingham, AL 35294 USA. EM dgclark@uab.edu FU Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service [E6553W]; Alzheimer's Disease Research Center (Marson, PI) [2R01 AG021927, 1P50 AG16582] FX The research reported here was supported by the Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service (E6553W, PI David Clark, Department of Neurology). In addition, the work was supported by grants 2R01 AG021927 (Marson, PI) and 1P50 AG16582 (Alzheimer's Disease Research Center) (Marson, PI). NR 57 TC 3 Z9 3 U1 0 U2 13 PU ELSEVIER MASSON PI MILANO PA VIA PALEOCAPA 7, 20121 MILANO, ITALY SN 0010-9452 EI 1973-8102 J9 CORTEX JI Cortex PD JUN PY 2014 VL 55 SI SI BP 202 EP 218 DI 10.1016/j.cortex.2013.12.013 PG 17 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA AJ5ZY UT WOS:000337770700017 PM 24556551 ER PT J AU Bakaeen, FG Reda, DJ Gelijns, AC Cornwell, L Omer, S Al Jurdi, R Kougias, P Anaya, D Berger, DH Huang, GD AF Bakaeen, Faisal G. Reda, Domenic J. Gelijns, Annetine C. Cornwell, Lorraine Omer, Shuab Al Jurdi, Rayan Kougias, Panos Anaya, Daniel Berger, David H. Huang, Grant D. TI Department of Veterans Affairs Cooperative Studies Program Network of Dedicated Enrollment Sites Implications for Surgical Trials SO JAMA SURGERY LA English DT Article ID PERCUTANEOUS CORONARY INTERVENTION; OUTCOMES RESEARCH-INSTITUTE; ARTERY-BYPASS SURGERY; RANDOMIZED-TRIAL; VALVE-REPLACEMENT; ON-PUMP; REPAIR AB IMPORTANCE Surgical clinical trials have played a critical role in shaping clinical practice, yet their launch and conduct remain challenging. Innovative approaches to carrying out such studies can not only help transform how trials produce definitive evidence but also move the field toward increased participation in trials. OBJECTIVE To review a recently launched pilot program aimed at enhancing patient enrollment and improving surgical trial operations at individual sites and nationally. SETTING AND PARTICIPANTS After a solicitation to create a national network focused on making the conduct of clinical trials more efficient, 10 Department of Veterans Affairs (VA) sites were selected. These sites, collectively called the Cooperative Studies Program (CSP) Network of Dedicated Enrollment Sites (NODES), were evaluated with regard to their previous participation in CSP multisite trials, the strength of the local clinical research environment, and presentation of innovative plans to coordinate and enhance the operations of local CSP studies and share best practices with other centers. Node accountability was also emphasized and involved metrics that tracked productivity and efficiency. RESULTS Building from available CSP experience in a range of clinical trials, including ones involving surgical interventions, NODES provides VA surgeons with resources for facilitating timely study initiation, determining patient availability, and addressing enrollment barriers. Such resources are particularly important for surgical studies, which often face challenges in patient recruitment and retention. In addition, NODES can maintain qualified and trained personnel at sites to support surgeons with limited time to fulfill the numerous administrative and regulatory responsibilities that often fall to the investigators. CONCLUSIONS AND RELEVANCE The VA's approach to enhancing trial efficiency may reinvigorate interest in surgical trials by offering a redesigned cooperative framework that builds on a core of high-yield sites and could mitigate traditional limitations of surgical trials. C1 [Bakaeen, Faisal G.; Cornwell, Lorraine; Omer, Shuab; Kougias, Panos; Anaya, Daniel; Berger, David H.] Baylor Coll Med, Michael E DeBakey VA Med Ctr, Dept Surg, Houston, TX 77030 USA. [Bakaeen, Faisal G.] Texas Heart Inst, Dept Cardiovasc Surg, Houston, TX 77025 USA. [Reda, Domenic J.; Huang, Grant D.] US Dept Vet Affairs, Cooperat Studies Program Cent Off, Washington, DC USA. [Gelijns, Annetine C.] Mt Sinai Sch Med, Dept Hlth Evidence & Policy, New York, NY USA. [Al Jurdi, Rayan] Michael E DeBakey VA Med Ctr, Houston, TX USA. RP Bakaeen, FG (reprint author), Michael E DeBakey VA Med Ctr, Div Cardiothorac Surg, Mail Stop OCL 112,2002 Holcombe Blvd, Houston, TX 77030 USA. EM fbakaeen@bcm.edu FU Department of Veterans Affairs Cooperative Studies Program FX This work was supported by the Department of Veterans Affairs Cooperative Studies Program. NR 25 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD JUN PY 2014 VL 149 IS 6 BP 507 EP 513 DI 10.1001/jamasurg.2013.4150 PG 7 WC Surgery SC Surgery GA AJ7WB UT WOS:000337909900005 PM 24647851 ER PT J AU Imel, ZE Baldwin, SA Baer, JS Hartzler, B Dunn, C Rosengren, DB Atkins, DC AF Imel, Zac E. Baldwin, Scott A. Baer, John S. Hartzler, Bryan Dunn, Chris Rosengren, David B. Atkins, David C. TI Evaluating Therapist Adherence in Motivational Interviewing by Comparing Performance With Standardized and Real Patients SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY LA English DT Article DE motivational interviewing; therapist adherence; mixed models; standardized patients ID ALLIANCE-OUTCOME CORRELATION; COMPETENCE; CLINICIAN; DEPENDABILITY; VARIABILITY; ASSESSMENTS; SESSIONS; BEHAVIOR; LARGER; THINK AB Objective: The goal of measuring therapist adherence is to determine whether a therapist can perform a given treatment. Yet, the evaluation of therapist behaviors in most clinical trials is limited. Typically, randomized trials have few therapists and minimize therapist variability through training and supervision. Furthermore, therapist adherence is confounded with uncontrolled differences in patients across therapists. Consequently, the extent to which adherence measures capture differences in actual therapist adherence versus other sources of variance is unclear. Method: We estimated intra-class correlations (ICCs) for therapist adherence in sessions with real and standardized patients (RPs and SPs), using ratings from a motivational interviewing (MI) dissemination trial (Baer et al., 2009) in which 189 therapists recorded 826 sessions with both patient types. We also examined the correlations of therapist adherence between SP and RP sessions, and the reliability of therapist level adherence scores with generalizability coefficients (GCs). Results: ICCs for therapist adherence were generally large (average ICC for SPs = .44; average ICC for RPs = .40), meaning that a given therapist's adherence scores were quite similar across sessions. Both ICCs and GCs were larger for SP sessions compared to RPs on global measures of MI adherence, such as Empathy and MI Spirit. Correlations between therapist adherence with real and standardized patients were moderate to large on 3 of 5 adherence measures. Conclusion: Differences in therapist-level adherence ratings were substantial, and standardized patients have promise as tools to evaluate therapist behavior. C1 [Imel, Zac E.] Univ Utah, Dept Educ Psychol, Salt Lake City, UT 84112 USA. [Baldwin, Scott A.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. [Baer, John S.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA. [Baer, John S.] VA Puget Sound Healthcare Syst, CESATE, Seattle, WA USA. [Hartzler, Bryan] Univ Washington, Alcohol Drug Abuse Inst, Seattle, WA 98195 USA. [Dunn, Chris; Atkins, David C.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Rosengren, David B.] Prevent Res Inst, Lexington, KY USA. RP Imel, ZE (reprint author), Univ Utah, Dept Educ Psychol, 1705 Campus Ctr Dr,Room 327, Salt Lake City, UT 84112 USA. EM zac.imel@utah.edu RI Baldwin, Scott/G-4021-2017 OI Baldwin, Scott/0000-0003-3428-0437; imel, zachary/0000-0001-9645-7184; Atkins, David/0000-0002-5781-9880 FU NIAAA NIH HHS [R01 AA018673, R01/AA018673]; NIDA NIH HHS [R01/DA016360, R34 DA034860, R34/DA034860, U10 DA013714] NR 28 TC 13 Z9 13 U1 2 U2 8 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-006X EI 1939-2117 J9 J CONSULT CLIN PSYCH JI J. Consult. Clin. Psychol. PD JUN PY 2014 VL 82 IS 3 BP 472 EP 481 DI 10.1037/a0036158 PG 10 WC Psychology, Clinical SC Psychology GA AJ7SF UT WOS:000337896700009 PM 24588405 ER PT J AU Watts, LT Long, JA Chemello, J Van Koughnet, S Fernandez, A Huang, SL Shen, Q Duong, TQ AF Watts, Lora Talley Long, Justin Alexander Chemello, Jonathan Van Koughnet, Samantha Fernandez, Angelica Huang, Shiliang Shen, Qiang Duong, Timothy Q. TI Methylene Blue Is Neuroprotective against Mild Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE antioxidant; mitochondria; MRI; oxidative stress; vasogenic edema ID SPINAL-CORD-INJURY; CYCLOSPORINE-A; NEURONAL DEGENERATION; OXYGEN-CONSUMPTION; CEREBRAL-ISCHEMIA; REACTIVE GLIOSIS; FLUORO-JADE; MECHANISMS; GENERATION; PERFUSION AB Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Methylene blue (MB) has known energy-enhancing and antioxidant properties. This study tested the hypothesis that MB treatment reduces lesion volume and behavioral deficits in a rat model of mild TBI. In a randomized double-blinded design, animals received either MB (n = 5) or vehicle (n = 6) after TBI. Studies were performed on 0, 1, 2, 7, and 14 days following an impact to the primary forelimb somatosensory cortex. MRI lesion was not apparent 1 h after TBI, became apparent 3 h after TBI, and peaked at 2 days for both groups. The MB-treated animals showed significantly smaller MRI lesion volume than the vehicle-treated animals at all time points studied. The MB-treated animals exhibited significantly improved scores on forelimb placement asymmetry and foot fault tests than did the vehicle-treated animals at all time points studied. Smaller numbers of dark-stained Nissl cells and Fluoro-Jade (R) positive cells were observed in the MB-treated group than in vehicle-treated animals 14 days post-TBI. In conclusion, MB treatment minimized lesion volume, behavioral deficits, and neuronal degeneration following mild TBI. MB is already approved by the United States Food and Drug Administration (FDA) to treat a number of indications, likely expediting future clinical trials in TBI. C1 [Watts, Lora Talley; Long, Justin Alexander; Chemello, Jonathan; Van Koughnet, Samantha; Fernandez, Angelica; Huang, Shiliang; Shen, Qiang; Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Watts, Lora Talley] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA. [Watts, Lora Talley; Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA. [Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. [Duong, Timothy Q.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Duong, TQ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, 8403 Floyd Curl Dr, San Antonio, TX 78229 USA. EM wattsl@uthscsa.edu; duongt@uthscsa.edu NR 45 TC 15 Z9 16 U1 0 U2 9 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 1 PY 2014 VL 31 IS 11 BP 1063 EP 1071 DI 10.1089/neu.2013.3193 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AJ7RS UT WOS:000337895300009 ER PT J AU Scheiner, DL Keilp, J Mindt, MR Burke, AK Oquendo, MA Mann, JJ AF Scheiner, Diane L. Keilp, John Mindt, Monica Rivera Burke, Ainsley K. Oquendo, Maria A. Mann, J. John TI Verbal Learning Deficits in Posttraumatic Stress Disorder and Depression SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID PSYCHIATRIC-DISORDERS; HOLOCAUST SURVIVORS; MEMORY PERFORMANCE; SUICIDE ATTEMPTERS; MAJOR DEPRESSION; COMBAT VETERANS; PTSD; ATTENTION; COMORBIDITY; DYSFUNCTION AB Verbal learning and memory deficits are frequently reported in posttraumatic stress disorder (PTSD), but may be a product of its psychiatric comorbidities, especially major depressive disorder (MDD). To evaluate this hypothesis, 25 medication-free patients with PTSD and comorbid MDD were compared to 148 medication-free patients with equally severe MDD alone and to 96 nonpatients on a measure of verbal learning and memory. Additional measures of attention, working memory, and executive function were administered to evaluate their contribution to verbal memory impairment. Patients with comorbid PTSD and MDD demonstrated the greatest deficit in verbal learning compared to both MDD patients and nonpatients (omnibus effect sizes ranged d = 0.41 to 0.50), one that was not accounted for by other cognitive deficits. Findings suggest that a current diagnosis of PTSD makes a contribution to verbal learning deficits beyond the effect of depression alone. C1 [Scheiner, Diane L.; Mindt, Monica Rivera] Fordham Univ, Dept Psychol, Bronx, NY 10458 USA. [Keilp, John; Burke, Ainsley K.; Oquendo, Maria A.; Mann, J. John] Columbia Univ, Dept Psychiat, New York, NY USA. [Keilp, John; Burke, Ainsley K.; Oquendo, Maria A.; Mann, J. John] New York State Psychiat Inst & Hosp, Div Mol Imaging & Neuropathol, New York, NY 10032 USA. RP Scheiner, DL (reprint author), West Los Angeles Healthcare Ctr, VA Greater Los Angeles Healthcare Syst, Psychol Dept 116B, Bldg 256,Room 204,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM dscheiner@fordham.edu FU NIMH NIH HHS [5P50 MH-62185, MH-62155] NR 55 TC 2 Z9 2 U1 3 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 EI 1573-6598 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2014 VL 27 IS 3 BP 291 EP 298 DI 10.1002/jts.21921 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AJ8JM UT WOS:000337949300006 PM 24850268 ER PT J AU Price, M Davidson, TM Ruggiero, KJ Acierno, R Resnick, HS AF Price, Matthew Davidson, Tatiana M. Ruggiero, Kenneth J. Acierno, Ron Resnick, Heidi S. TI Predictors of Using Mental Health Services After Sexual Assault SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL COMORBIDITY SURVEY; RAPE MEDICAL-CARE; SUBSTANCE USE; EARLY INTERVENTION; TREATMENT-SEEKING; TRAUMATIC INJURY; RECENT VICTIMS; UNITED-STATES; HELP-SEEKING AB Sexual assault increases the risk for psychopathology. Despite the availability of effective interventions, relatively few victims who need treatment receive care in the months following an assault. Prior work identified several factors associated with utilizing care, including ethnicity, insurance, and posttraumatic stress disorder (PTSD) symptoms. Few studies, however, have examined predictors of treatment utilization prospectively from the time of assault. The present study hypothesized that White racial status, younger age, being partnered, having health insurance, having previously received mental health treatment, and having more PTSD and depression symptoms would predict utilization of care in the 6 months postassault. This was examined in a sample of 266 female sexual assault victims with an average age of 26.2 years, of whom 62.0% were White and 38.0% were African American assessed at 1.5 and 6 months postassault. Available information on utilizing care varied across assessments (1.5 months, n = 214; 3 months, n = 126; 6 months, n = 204). Significant predictors included having previously received mental health treatment (OR = 4.09), 1 day depressive symptoms (OR = 1.06), and having private insurance (OR = 2.24) or Medicaid (OR = 2.19). Alcohol abuse and prior mental health care were associated with a substantial increase in treatment utilization (OR = 4.07). The findings highlight the need to help victims at risk obtain treatment after sexual assault. C1 [Price, Matthew] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA. [Davidson, Tatiana M.; Ruggiero, Kenneth J.; Acierno, Ron; Resnick, Heidi S.] Med Univ S Carolina, Natl Crime Victims Ctr, Charleston, SC 29425 USA. [Ruggiero, Kenneth J.; Acierno, Ron] Ralph H Johnson VA Med Ctr, Charleston, SC USA. RP Resnick, HS (reprint author), Med Univ S Carolina, Natl Crime Victims Ctr, Natl Crime Victims Res & Treatment Ctr, 67 President St, Charleston, SC 29425 USA. EM resnickh@musc.edu FU NIDA NIH HHS [R01 DA023099, R01 DA011158, R01DA023099, R01DA11158]; NIMH NIH HHS [T32 MH018869, T32MH018869] NR 54 TC 10 Z9 10 U1 5 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 EI 1573-6598 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2014 VL 27 IS 3 BP 331 EP 337 DI 10.1002/jts.21915 PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AJ8JM UT WOS:000337949300011 PM 24852357 ER PT J AU Tang, Y Gellad, WF Men, A Donohue, JM AF Tang, Yan Gellad, Walid F. Men, Aiju Donohue, Julie M. TI Impact of Medicare Part D Plan Features on Use of Generic Drugs SO MEDICAL CARE LA English DT Article DE Medicare Part D; cost-sharing; prior authorization; step therapy; generic drugs ID D BENEFICIARIES; HEART-FAILURE; ADHERENCE; COST; COPAYMENT; PHYSICIAN; PERCEPTIONS; PROGRAM; CHOICE AB Background:Little is known about how Medicare Part D plan features influence choice of generic versus brand drugs.Objectives:To examine the association between Part D plan features and generic medication use.Methods:Data from a 2009 random sample of 1.6 million fee-for-service, Part D enrollees aged 65 years and above, who were not dually eligible or receiving low-income subsidies, were used to examine the association between plan features (generic cost-sharing, difference in brand and generic copay, prior authorization, step therapy) and choice of generic antidepressants, antidiabetics, and statins. Logistic regression models accounting for plan-level clustering were adjusted for sociodemographic and health status.Results:Generic cost-sharing ranged from $0 to $9 for antidepressants and statins, and from $0 to $8 for antidiabetics (across 5th-95th percentiles). Brand-generic cost-sharing differences were smallest for statins (5th-95th percentiles: $16-$37) and largest for antidepressants ($16-$64) across plans. Beneficiaries with higher generic cost-sharing had lower generic use [adjusted odds ratio (OR)=0.97, 95% confidence interval (CI), 0.95-0.98 for antidepressants; OR=0.97, 95% CI, 0.96-0.98 for antidiabetics; OR=0.94, 95% CI, 0.92-0.95 for statins]. Larger brand-generic cost-sharing differences and prior authorization were significantly associated with greater generic use in all categories. Plans could increase generic use by 5-12 percentage points by reducing generic cost-sharing from the 75th ($7) to 25th percentiles ($4-$5), increasing brand-generic cost-sharing differences from the 25th ($25-$26) to 75th ($32-$33) percentiles, and using prior authorization and step therapy.Conclusions:Cost-sharing features and utilization management tools were significantly associated with generic use in 3 commonly used medication categories. C1 [Tang, Yan; Men, Aiju; Donohue, Julie M.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Hlth Policy & Management, Pittsburgh, PA 15261 USA. [Gellad, Walid F.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Gellad, Walid F.] Univ Pittsburgh, Div Gen Med, Pittsburgh, PA 15261 USA. [Gellad, Walid F.] Univ Pittsburgh, Ctr Pharmaceut Policy & Prescribing, Pittsburgh, PA 15261 USA. [Gellad, Walid F.] RAND Hlth, Pittsburgh, PA USA. RP Tang, Y (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Hlth Policy & Management, 130 DeSoto St,Crabtree Hall A663, Pittsburgh, PA 15261 USA. EM yat11@pitt.edu OI Donohue, Julie/0000-0003-2418-6017 FU RAND-University of Pittsburgh Health Initiative (RUPHI); Clinical and Translational Science Institute at the University of Pittsburgh; National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program [UL1RR024153, UL1TR000005]; VA HSR&D Career Development Award [CDA09-207] FX Supported by a pilot grant funded by both RAND-University of Pittsburgh Health Initiative (RUPHI) and the Clinical and Translational Science Institute at the University of Pittsburgh, which is supported by the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program (grants UL1RR024153 and UL1TR000005). W. F. G. is additionally supported by a VA HSR&D Career Development Award (CDA09-207). NR 46 TC 1 Z9 1 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD JUN PY 2014 VL 52 IS 6 BP 541 EP 548 DI 10.1097/MLR.0000000000000142 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AJ5LK UT WOS:000337723900012 PM 24824538 ER PT J AU Byrne, T Fargo, JD Montgomery, AE Munley, E Culhane, DP AF Byrne, Thomas Fargo, Jamison D. Montgomery, Ann Elizabeth Munley, Ellen Culhane, Dennis P. TI The Relationship between Community Investment in Permanent Supportive Housing and Chronic Homelessness SO SOCIAL SERVICE REVIEW LA English DT Article ID NEW-YORK-CITY; MENTAL-ILLNESS; RENT CONTROL; COST-EFFECTIVENESS; HEALTH-CARE; SERVICE USE; PHILADELPHIA; PROGRAM; ADULTS; INDIVIDUALS AB In recent years, permanent supportive housing (PSH) has emerged as the preferred intervention for addressing chronic homelessness in the United States. However, almost all prior studies examining the effectiveness of PSH have been conducted at the individual level, with only minimal attempts to empirically test the relationship between PSH and chronic homelessness at the community level. This study uses longitudinal data collected by the US Department of Housing and Urban Development (HUD) and several other sources to model the relationship between measures of community investment in PSH and rates of chronic homelessness. The results show modest negative associations between increased investment in PSH and rates of chronic homelessness over time. We discuss the implications of these findings for ongoing efforts to address chronic homelessness and future research. C1 [Byrne, Thomas; Culhane, Dennis P.] Univ Penn, Sch Social Policy & Practice, Philadelphia, PA 19104 USA. [Byrne, Thomas; Fargo, Jamison D.; Montgomery, Ann Elizabeth; Munley, Ellen; Culhane, Dennis P.] US Dept Vet Affairs, Washington, DC USA. [Fargo, Jamison D.] Utah State Univ, Logan, UT 84322 USA. RP Byrne, T (reprint author), Univ Penn, Sch Social Policy & Practice, Philadelphia, PA 19104 USA. NR 54 TC 6 Z9 6 U1 5 U2 29 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0037-7961 EI 1537-5404 J9 SOC SERV REV JI Soc. Serv. Rev. PD JUN PY 2014 VL 88 IS 2 BP 234 EP 263 DI 10.1086/676142 PG 30 WC Social Work SC Social Work GA AJ5QV UT WOS:000337741600002 ER PT J AU Brahmbhatt, R Carter, SA Hicks, SC Berger, DH Liang, MK AF Brahmbhatt, Reshma Carter, Stacey A. Hicks, Stephanie C. Berger, David H. Liang, Mike K. TI Identifying Risk Factors for Surgical Site Complications after Laparoscopic Ventral Hernia Repair: Evaluation of the Ventral Hernia Working Group Grading System SO SURGICAL INFECTIONS LA English DT Article ID INCISIONAL HERNIA; WOUND-INFECTION; MESH; HERNIORRHAPHY; METAANALYSIS; RECURRENCE; OUTCOMES AB Background: In 2010, the Ventral Hernia Working Group (VHWG) published a grading system to assess the risk of surgical site complications in patients undergoing ventral hernia repair. This study evaluated the predictive value of the VHWG classification for the surgical outcomes of laparoscopic ventral hernia repair (LVHR) and identified independent factors associated with surgical site infection (SSI) and surgical site occurrence (SSO). Methods: A retrospective review was performed of all patients who underwent LVHR over a 10-year period at two institutions. The U.S. Centers for Disease Control and Prevention definition of SSI and the VHWG definition of SSO were used. Univariable analysis was performed using the Student t-test, analysis of variance, chi-square test, or Fisher exact test, as appropriate. Multivariable analysis was used to identify independent factors associated with SSI and SSO. Results: Differences in American Society of Anesthesiologists class, body mass index, diabetes mellitus, chronic obstructive pulmonary disease, tobacco use, hernia type, prior abdominal surgery, prior ventral hernia repair, hernia size, and total infections were identified by grade. There was no difference in SSI or SSO by grade. Multivariable analysis revealed institution and number of prior abdominal operations to be associated with SSI. Institution, prostate disease, and prior ventral hernia repair were associated with SSO. Conclusions: The VHWG classification was unable to predict SSI and SSO and may not be applicable in LVHR. This study identified independent factors associated with SSI and SSO in LVHR. Although further study is warranted to validate these results, the factors presented may be a useful tool to stratify patient risk of SSI and SSO with LVHR. C1 [Brahmbhatt, Reshma; Carter, Stacey A.; Berger, David H.; Liang, Mike K.] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Michael E DeBakey Dept Surg, Houston, TX 77030 USA. [Hicks, Stephanie C.] Rice Univ, Dept Stat, Houston, TX 77251 USA. RP Liang, MK (reprint author), Michael E DeBakey VAMC, 2002 Holcombe Blvd,OCL 112, Houston, TX 77030 USA. EM ml3@bcm.edu RI Liang, Mike/L-8493-2015 OI Liang, Mike/0000-0001-7063-7291; Hicks, Stephanie/0000-0002-7858-0231 FU Lifecell; KCI; Acell FX R.B., S.A.C., S.C.H., and D.H.B. declare no competing financial interests. M. K. L. has held research grants from Lifecell and unrestricted education grants from Lifecell, KCI, and Acell. NR 40 TC 7 Z9 7 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-2964 EI 1557-8674 J9 SURG INFECT JI Surg. Infect. PD JUN PY 2014 VL 15 IS 3 BP 187 EP 193 DI 10.1089/sur.2012.179 PG 7 WC Infectious Diseases; Surgery SC Infectious Diseases; Surgery GA AJ9EI UT WOS:000338009600006 PM 24773169 ER PT J AU Miller, RA Harrison, DE Astle, CM Fernandez, E Flurkey, K Han, M Javors, MA Li, XN Nadon, NL Nelson, JF Pletcher, S Salmon, AB Sharp, ZD Van Roekel, S Winkleman, L Strong, R AF Miller, Richard A. Harrison, David E. Astle, Clinton M. Fernandez, Elizabeth Flurkey, Kevin Han, Melissa Javors, Martin A. Li, Xinna Nadon, Nancy L. Nelson, James F. Pletcher, Scott Salmon, Adam B. Sharp, Zelton Dave Van Roekel, Sabrina Winkleman, Lynn Strong, Randy TI Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction SO AGING CELL LA English DT Article DE aging; caloric restriction; glucose; IGF-1; insulin; longevity; mouse; mTOR; rapamycin; xenobiotic metabolism ID GENETICALLY HETEROGENEOUS MICE; INTERVENTIONS TESTING PROGRAM; AMES DWARF MICE; INSULIN SENSITIVITY; EXTENSION; LONGEVITY; TOR; RESISTANCE; PATHWAY; GENES AB Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in both sexes. Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism in blood levels of this drug. Some of the endocrine and metabolic changes seen in diet-restricted mice are not seen in mice exposed to rapamycin, and the pattern of expression of hepatic genes involved in xenobiotic metabolism is also quite distinct in rapamycin-treated and diet-restricted mice, suggesting that these two interventions for extending mouse lifespan differ in many respects. C1 [Miller, Richard A.; Han, Melissa; Li, Xinna; Van Roekel, Sabrina; Winkleman, Lynn] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA. [Miller, Richard A.; Han, Melissa; Li, Xinna; Pletcher, Scott; Van Roekel, Sabrina; Winkleman, Lynn] Univ Michigan, Geriatr Ctr, Ann Arbor, MI 48109 USA. [Harrison, David E.; Astle, Clinton M.; Flurkey, Kevin] Jackson Lab, Bar Harbor, ME 04609 USA. [Fernandez, Elizabeth; Strong, Randy] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX 78229 USA. [Fernandez, Elizabeth; Strong, Randy] South Texas Vet Hlth Care Syst, Res Serv, San Antonio, TX 78229 USA. [Javors, Martin A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA. [Nadon, Nancy L.] NIA, Div Aging Biol, Bethesda, MD 20892 USA. [Nelson, James F.] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA. [Nelson, James F.; Salmon, Adam B.; Sharp, Zelton Dave; Strong, Randy] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. [Pletcher, Scott] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA. [Sharp, Zelton Dave] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78245 USA. RP Miller, RA (reprint author), Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA. EM millerr@umich.edu FU NIH [AG022303, AG031736, AG022307, AG013319, AG022308, CA034196]; Department of Veterans Affairs FX This work was supported by NIH grants AG022303, AG031736 (RAM), AG022307, AG013319 (RS), and AG022308 (DEH), with important facilities supported by CA034196 (DEH) and the Department of Veterans Affairs (RS), We thank Lili Deng and Andrzej Galecki for statistical assistance, Jeff Halter for comments on an early draft of the paper, and Lisa Burmeister, Vivian Diaz, Nelson Durgin, Vicki Ingalls, Amanda Keedle, and Pam J Krason for technical assistance. NR 46 TC 107 Z9 109 U1 2 U2 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1474-9718 EI 1474-9726 J9 AGING CELL JI Aging Cell PD JUN PY 2014 VL 13 IS 3 BP 468 EP 477 DI 10.1111/acel.12194 PG 10 WC Cell Biology; Geriatrics & Gerontology SC Cell Biology; Geriatrics & Gerontology GA AJ2VV UT WOS:000337523400009 PM 24341993 ER PT J AU Buck, KJ Iancu, OD Walter, NAR AF Buck, K. J. Iancu, O. D. Walter, N. A. R. TI QUANTITIATIVE TRAIT LOCUS (QTL), GENE EXPRESSION AND COEXPRESSION NETWORK ANALYSES IDENTIFY A ROLE FOR OXIDATIVE PHOSPHORYLATION IN ETHANOL WITHDRAWAL SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 Portland VA Med Ctr, Dept Behav Neurosci, Portland, OR 97239 USA. Portland VA Med Ctr, Portland Alcohol Res Ctr, Portland, OR 97239 USA. Oregon Hlth & Sci Univ, Portland, OR 97239 USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0011 BP 3A EP 3A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523700012 ER PT J AU Williams, EC Lapham, GT Lee, AK Richards, JE Berger, DB Ludman, E Bradley, KA AF Williams, E. C. Lapham, G. T. Lee, A. K. Richards, J. E. Berger, D. B. Ludman, E. Bradley, K. A. TI READINESS TO CHANGE AND SEVERITY OF UNHEALTHY ALCOHOL USE AMONG PRIMARY CARE PATIENTS RECRUITED TO A TRIAL OF COLLABORATIVE CARE SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 [Williams, E. C.] VA Puget Sound HSR&D COIN, Seattle, WA USA. [Williams, E. C.] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Lapham, G. T.; Lee, A. K.; Richards, J. E.; Ludman, E.; Bradley, K. A.] Grp Hlth Res Inst, Seattle, WA USA. [Berger, D. B.] VA Puget Sound, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0226 BP 57A EP 57A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523700227 ER PT J AU Hawkins, EJ Lapham, GT Lee, AK Kivlahan, DR Berger, BD Hebert, PL Saxon, AJ Bradley, KA AF Hawkins, E. J. Lapham, G. T. Lee, A. K. Kivlahan, D. R. Berger, B. D. Hebert, P. L. Saxon, A. J. Bradley, K. A. TI PREVALENCE AND COMORBIDITY OF PTSD AMONG HEAVY DRINKERS ENROLLED IN A COLLABORATIVE CARE TRIAL FOR ALCOHOL USE DISORDERS IN VA PRIMARY CARE SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 Grp Hlth Res Inst, Seattle, WA 98101 USA. VA Puget Sound Hlth Care Syst, Seattle, WA 98118 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0252 BP 63A EP 63A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523700253 ER PT J AU Bradley, KA Lapham, GT Richards, J Merrill, JO Williams, EC Lee, AK Holden, E Chavez, LJ Kivlahan, DR AF Bradley, K. A. Lapham, G. T. Richards, J. Merrill, J. O. Williams, E. C. Lee, A. K. Holden, E. Chavez, L. J. Kivlahan, D. R. TI THE PREVALENCE OF DSM-IV VERSUS DSM-5 ALCOHOL USE DISORDERS (AUD) IN PRIMARY CARE PATIENTS AT HIGH RISK FOR AUD IN THE CHOICE TRIAL SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 Univ Washington, VA Puget Sound, HSR&D COIN & Gen Med Serv, Grp Hlth Res Inst,Dept Med, Seattle, WA 98195 USA. Univ Washington, VA Puget Sound, HSR&D COIN & Gen Med Serv, Grp Hlth Res Inst,Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. Univ Washington, VA Puget Sound, HSR&D COIN & Gen Med Serv, Grp Hlth Res Inst,Dept Hlth Serv, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0493 BP 124A EP 124A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523700494 ER PT J AU Pennington, DL Lasher, BA Herbst, E Schrodek, E Hong, E Waldrop, A Heinz, A Williams, C Abrams, G Neylan, TC Seal, K Carney, C Besterman, A Batki, SL AF Pennington, D. L. Lasher, B. A. Herbst, E. Schrodek, E. Hong, E. Waldrop, A. Heinz, A. Williams, C. Abrams, G. Neylan, T. C. Seal, K. Carney, C. Besterman, A. Batki, S. L. TI COGNITION AND SELF-REGULATION IN VETERANS WITH ALCOHOL USE DISORDER, PTSD AND TBI: BASELINE SUBJECT CHARACTERISTICS IN TOPIRAMATE TREATMENT TRIALS SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 [Pennington, D. L.; Lasher, B. A.; Herbst, E.; Schrodek, E.; Hong, E.; Waldrop, A.; Heinz, A.; Williams, C.; Abrams, G.; Neylan, T. C.; Seal, K.; Carney, C.; Besterman, A.; Batki, S. L.] UCSF Dept Psychiat, Addict Res Program, San Francisco VA Med Ctr, San Francisco, CA 94121 USA. NR 0 TC 0 Z9 0 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0547 BP 137A EP 137A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523700548 ER PT J AU Gubner, NR Phillips, TJ AF Gubner, N. R. Phillips, T. J. TI EFFECTS OF VARENICLINE ON THE EXPRESSION OF ETHANOL-INDUCED LOCOMOTOR SENSITIZATION, A MOUSE MODEL OF NEUROADAPTATION SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 [Gubner, N. R.; Phillips, T. J.] Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland Alcohol Res Ctr, Dept Behav Neurosci, Portland, OR 97239 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0622 BP 156A EP 156A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523700623 ER PT J AU Krenek, M Simpson, TL AF Krenek, M. Simpson, T. L. TI DEGREE OF CORRESPONDENCE BETWEEN DAILY MONITORING AND RETROSPECTIVE RECALL OF ALCOHOL USE AMONG INDIVIDUALS WITH COMORBID AUD AND PTSD SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 [Krenek, M.; Simpson, T. L.] VA Puget Sound Healthcare Syst, Seattle Div, Seattle, WA 98108 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0823 BP 206A EP 206A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701023 ER PT J AU Collins, SE Duncan, MH Smart, BF Saxon, AJ Malone, DK Jackson, TR Ries, RK AF Collins, S. E. Duncan, M. H. Smart, B. F. Saxon, A. J. Malone, D. K. Jackson, T. R. Ries, R. K. TI A PILOT STUDY OF EXTENDED-RELEASE NALTREXONE AND HARM REDUCTION COUNSELING FOR CHRONICALLY HOMELESS PEOPLE WITH ALCOHOL DEPENDENCE SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 [Collins, S. E.; Duncan, M. H.; Smart, B. F.; Ries, R. K.] Univ Washington, Seattle, WA 98195 USA. [Saxon, A. J.] VA Puget Sound, Seattle, WA 98108 USA. [Malone, D. K.] DESC, Seattle, WA 98104 USA. [Jackson, T. R.] Evergreen Treatment Serv, Seattle, WA 98134 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0850 BP 213A EP 213A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701050 ER PT J AU Batki, SL Pennington, DL Lasher, BA Herbst, E Schrodek, E Hong, E Waldrop, A Heinz, A Williams, C Abrams, G Neylan, TC Seal, K Carney, C Besterman, A AF Batki, S. L. Pennington, D. L. Lasher, B. A. Herbst, E. Schrodek, E. Hong, E. Waldrop, A. Heinz, A. Williams, C. Abrams, G. Neylan, T. C. Seal, K. Carney, C. Besterman, A. TI ALCOHOL USE DISORDER AND PTSD SEVERITY IN VETERANS WITH AND WITHOUT COMORBID TBI: BASELINE SUBJECT CHARACTERISTICS IN TOPIRAMATE TREATMENT TRIALS SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 [Batki, S. L.; Pennington, D. L.; Lasher, B. A.; Herbst, E.; Schrodek, E.; Hong, E.; Waldrop, A.; Heinz, A.; Williams, C.; Abrams, G.; Neylan, T. C.; Seal, K.; Carney, C.; Besterman, A.] Univ Calif San Francisco, Dept Psychiat, Addict Res Program, San Francisco VA Med Ctr, San Francisco, CA 94121 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0855 BP 214A EP 214A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701055 ER PT J AU Barkley-Levenson, AM Crabbe, JC AF Barkley-Levenson, A. M. Crabbe, J. C. TI NEUROPEPTIDE Y AND BINGE-LIKE DRINKING IN HIGH DRINKING IN THE DARK SELECTED MICE SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland Alcohol Res Ctr, Portland, OR 97239 USA. Portland VA Med Ctr, Portland, OR 97239 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0896 BP 224A EP 224A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701096 ER PT J AU Wilhelm, CJ Beard, DR Hashimoto, JG Roberts, ML Loftis, JM Wiren, KM AF Wilhelm, C. J. Beard, D. R. Hashimoto, J. G. Roberts, M. L. Loftis, J. M. Wiren, K. M. TI DISTINCT GLUCOCORTICOID SIGNALING ASSOCIATED WITH ETHANOL-INDUCED INFLAMMOTOXICITY SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 Portland VA Med Ctr, Res Serv, Portland, OR 97239 USA. Oregon Hlth & Sci Univ, Portland, OR 97239 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0991 BP 248A EP 248A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701191 ER PT J AU McGinnis, K Tate, J Bryant, K Fiellin, D Justice, A AF McGinnis, K. Tate, J. Bryant, K. Fiellin, D. Justice, A. TI SENSITIVITY TO ALCOHOL INTOXICATION EFFECTS BY HIV STATUS AND TREATMENT SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. CT VA Healthcare Syst, Vet Aging Cohort Study, West Haven, CT USA. Yale Univ, New Haven, CT USA. NIAAA, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 1131 BP 283A EP 283A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701330 ER PT J AU Barkley-Levenson, AM Crabbe, JC AF Barkley-Levenson, A. M. Crabbe, J. C. TI BEHAVIORAL AND MOLECULAR CHARACTERISTICS OF MICE 'AT-RISK' FOR BINGE-LIKE DRINKING SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 Oregon Hlth & Sci Univ, Portland Alcohol Res Ctr, Dept Behav Neurosci, Portland, OR 97239 USA. Portland VA Med Ctr, Portland, OR 97239 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 247 BP 354A EP 354A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701614 ER PT J AU Rasmussen, DD Beckwith, LE Kincaid, CL Froehlich, JC AF Rasmussen, Dennis D. Beckwith, Lauren E. Kincaid, Carrie L. Froehlich, Janice C. TI Combining the 1-Adrenergic Receptor Antagonist, Prazosin, with the -Adrenergic Receptor Antagonist, Propranolol, Reduces Alcohol Drinking More Effectively Than Either Drug Alone SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Propranolol; Prazosin; Alcoholism Treatment; Noradrenergic ID PREFERRING P RATS; DEPENDENCE; ETHANOL; WITHDRAWAL; PREFERENCE AB Background Evidence suggests that activation of the noradrenergic system may contribute to alcohol drinking in animals and humans. Our previous studies demonstrated that blocking 1-adrenergic receptors with the antagonist, prazosin, decreased alcohol drinking in rats under various conditions. As noradrenergic activation is also regulated by -adrenergic receptors, we now examine the effects of the -adrenergic receptor antagonist, propranolol, alone or in combination with prazosin, on alcohol drinking in rats selectively bred for high voluntary alcohol intake and alcohol preference (P line). Methods Two studies were conducted with male P rats. In study 1, rats were allowed to become alcohol-dependent during 14weeks of ad libitum access to food, water, and 20% alcohol, and the effect of propranolol (5 to 15mg/kg, intraperitoneally [IP]) and prazosin (1 to 2mg/kg, IP) on alcohol intake during withdrawal was assessed. In study 2, the effect of propranolol (5mg/kg, IP) and prazosin (2mg/kg, IP) on alcohol intake following prolonged imposed abstinence was assessed. Results Alcohol drinking following propranolol treatment was variable, but the combination of propranolol+prazosin consistently suppressed alcohol drinking during both alcohol withdrawal and following prolonged imposed abstinence, and the combination of these 2 drugs was more effective than was treatment with either drug alone. Conclusions Treatment with prazosin+propranolol, or a combination of other centrally active 1- and -adrenergic receptor antagonists, may assist in preventing alcohol relapse in some individuals. C1 [Rasmussen, Dennis D.] VISN 20 Mental Illness Res Educ & Clin Ctr, Seattle, WA USA. [Rasmussen, Dennis D.; Beckwith, Lauren E.; Kincaid, Carrie L.] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. [Rasmussen, Dennis D.; Beckwith, Lauren E.; Kincaid, Carrie L.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Froehlich, Janice C.] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA. RP Rasmussen, DD (reprint author), VA Puget Sound Hlth Care Syst, Med Ctr, MIRECC 116, 1660 S Columbian Way, Seattle, WA 98108 USA. EM drasmuss@u.washington.edu FU NIH [R01 AA018604, P20 AA017839, AA018604, P60 AA007611, R24 AA15512] FX This material is based on work supported in part by resources from the VA Puget Sound Health Care System, the VA VISN 20 Mental Illness Research, Education and Clinical Center (MIRECC), and by NIH grants R01 AA018604, P20 AA017839 (DDR) and AA018604, P60 AA007611 (JCF). P rats were provided by the Alcohol Research Resource Center supported by NIH grant R24 AA15512. NR 28 TC 8 Z9 8 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 IS 6 BP 1532 EP 1539 DI 10.1111/acer.12441 PG 8 WC Substance Abuse SC Substance Abuse GA AJ2SI UT WOS:000337511400006 PM 24891220 ER PT J AU Medici, V Schroeder, DI Woods, R LaSalle, JM Geng, YZ Shibata, NM Peerson, J Hodzic, E Dayal, S Tsukamoto, H Kharbanda, KK Tillman, B French, SW Halsted, CH AF Medici, Valentina Schroeder, Diane I. Woods, Rima LaSalle, Janine M. Geng, Yongzhi Shibata, Noreene M. Peerson, Janet Hodzic, Emir Dayal, Sanjana Tsukamoto, Hidekazu Kharbanda, Kusum K. Tillman, Brittany French, Samuel W. Halsted, Charles H. TI Methylation and Gene Expression Responses to Ethanol Feeding and Betaine Supplementation in the Cystathionine Beta Synthase-Deficient Mouse SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Alcohol; S-Adenosylmethionine; S-Adenosylhomocysteine; Cystathionine Beta Synthase; DNA Methylation ID ALCOHOLIC LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; NITRIC-OXIDE SYNTHASE; GLOBAL DNA METHYLATION; MICROPIGS FED ETHANOL; ALPHA PPAR-ALPHA; METHIONINE METABOLISM; EPIGENETIC REGULATION; MICE; INJURY AB Background Alcoholic steatohepatitis (ASH) is caused in part by the effects of ethanol (EtOH) on hepatic methionine metabolism. Methods To investigate the phenotypic and epigenetic consequences of altered methionine metabolism in this disease, we studied the effects of 4-week intragastric EtOH feeding with and without the methyl donor betaine in cystathionine beta synthase (CS) heterozygous C57BL/6J mice. Results The histopathology of early ASH was induced by EtOH feeding and prevented by betaine supplementation, while EtOH feeding reduced and betaine supplementation maintained the hepatic methylation ratio of the universal methyl donor S-adenosylmethionine (SAM) to the methyltransferase inhibitor S-adenosylhomocysteine (SAH). MethylC-seq genomic sequencing of heterozygous liver samples from each diet group found 2 to 4% reduced methylation in gene bodies, but not promoter regions of all autosomes of EtOH-fed mice, each of which were normalized in samples from mice fed the betaine-supplemented diet. The transcript levels of nitric oxide synthase (Nos2) and DNA methyltransferase 1 (Dnmt1) were increased, while those of peroxisome proliferator receptor- (Ppar) were reduced in EtOH-fed mice, and each was normalized in mice fed the betaine-supplemented diet. DNA pyrosequencing of CS heterozygous samples found reduced methylation in a gene body of Nos2 by EtOH feeding that was restored by betaine supplementation and was correlated inversely with its expression and positively with SAM/SAH ratios. Conclusions The present study has demonstrated relationships among EtOH induction of ASH with aberrant methionine metabolism that was associated with gene body DNA hypomethylation in all autosomes and was prevented by betaine supplementation. The data imply that EtOH-induced changes in selected gene transcript levels and hypomethylation in gene bodies during the induction of ASH are a result of altered methionine metabolism that can be reversed through dietary supplementation of methyl donors. C1 [Medici, Valentina; Geng, Yongzhi; Shibata, Noreene M.; Halsted, Charles H.] Univ Calif Davis, Dept Internal Med, Sacramento, CA 95817 USA. [Schroeder, Diane I.; Woods, Rima; LaSalle, Janine M.] Univ Calif Davis, Dept Med Microbiol & Immunol, Genome Ctr, Sacramento, CA 95817 USA. Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA. [Peerson, Janet] Univ Calif Davis, Dept Nutr, Sacramento, CA 95817 USA. [Hodzic, Emir] Univ Calif Davis, Sch Vet Med, Real Time PCR & Res Diagnost Facil, Sacramento, CA 95817 USA. [Dayal, Sanjana] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA. [Tsukamoto, Hidekazu] Univ So Calif, Keck Sch Med, Southern Calif Res Ctr ALPD & Cirrhosis, Los Angeles, CA 90033 USA. [Tsukamoto, Hidekazu] Greater Los Angeles VA Healthcare Syst, Los Angeles, CA USA. [Kharbanda, Kusum K.] Vet Affairs Nebraska Western Iowa Hlth Care Syst, Res Serv, Omaha, NE USA. [Tillman, Brittany; French, Samuel W.] Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA. RP Medici, V (reprint author), Univ Calif Davis, Div Gastroenterol & Hepatol, Dept Internal Med, 4150 5 St,Suite 3500, Sacramento, CA 95817 USA. EM valentina.medici@ucdmc.ucdavis.edu RI Schroeder, Diane/I-2200-2015 OI Schroeder, Diane/0000-0003-2282-9912; LaSalle, Janine/0000-0002-3480-2031 FU National Institutes of Health [K08DK084111, R03AA020577-01, P50AA11991]; Southern California Research Center for ALPD and Cirrhosis; Morphology Core [P50AA11991]; Department of Veterans Affairs, Office of Research and Development [BX001155]; Liver Center [P30 DK026743]; Division of Gastroenterology and Hepatology at UC Davis; [R01ES021707] FX This research was supported by National Institutes of Health grant numbers K08DK084111 (to VM), R03AA020577-01 (to CHH), P50AA11991 Southern California Research Center for ALPD and Cirrhosis (to HT), P50AA11991 Morphology Core (to SWF), R01ES021707 (to JML and DIS), and by a Biomedical Laboratory Research and Development National Merit Review grant BX001155 from the Department of Veterans Affairs, Office of Research and Development (to KKK). VM is a member of the University of California San Francisco Liver Center (Liver Center grant number P30 DK026743) and received funds from the Division of Gastroenterology and Hepatology at UC Davis. The content is the sole responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 49 TC 7 Z9 7 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 IS 6 BP 1540 EP 1549 DI 10.1111/acer.12405 PG 10 WC Substance Abuse SC Substance Abuse GA AJ2SI UT WOS:000337511400007 PM 24730561 ER PT J AU Glass, JE Williams, EC Bucholz, KK AF Glass, Joseph E. Williams, Emily C. Bucholz, Kathleen K. TI Psychiatric Comorbidity and Perceived Alcohol Stigma in a Nationally Representative Sample of Individuals with DSM-5 Alcohol Use Disorder SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Perceived Stigma; Alcoholism Stigma; Alcohol; Psychiatric Disorders; Latent Class Analysis ID SUBSTANCE USE DISORDERS; LABELING THEORY APPROACH; LATENT CLASS ANALYSIS; DRUG-USE DISORDERS; UNITED-STATES; EPIDEMIOLOGIC SURVEY; MENTAL-DISORDERS; SEXUAL MINORITY; HEALTH; CONSEQUENCES AB Background Alcohol use disorder (AUD) is among the most stigmatized health conditions and is frequently comorbid with mood, anxiety, and drug use disorders. Theoretical frameworks have conceptualized stigma-related stress as a predictor of psychiatric disorders. We described profiles of psychiatric comorbidity among people with AUD and compared levels of perceived alcohol stigma across profiles. Methods Cross-sectional data were analyzed from a general population sample of U.S. adults with past-year DSM-5 AUD (n=3,368) from the National Epidemiologic Survey on Alcohol and Related Conditions, which was collected from 2001 to 2005. Empirically derived psychiatric comorbidity profiles were established with latent class analysis, and mean levels of perceived alcohol stigma were compared across the latent classes while adjusting for sociodemographic characteristics and AUD severity. Results Four classes of psychiatric comorbidity emerged within this AUD sample, including those with: (i) high comorbidity, reflecting internalizing (i.e., mood and anxiety disorders) and externalizing (i.e., antisocial personality and drug use disorders) disorders; (ii) externalizing comorbidity; (iii) internalizing comorbidity; and (iv) no comorbidity. Perceived alcohol stigma was significantly higher in those with internalizing comorbidity (but not those with high comorbidity) as compared to those with no comorbidity or externalizing comorbidity. Conclusions Perceived stigma, as manifested by anticipations of social rejection and discrimination, may increase risk of internalizing psychiatric comorbidity. Alternatively, internalizing psychiatric comorbidity could sensitize affected individuals to perceive more negative attitudes toward them. Future research is needed to understand causal and bidirectional associations between alcohol stigma and psychiatric comorbidity. C1 [Glass, Joseph E.] Univ Wisconsin, Sch Social Work, Madison, WI 53706 USA. [Williams, Emily C.] VA Puget Sound Hlth Care Syst, Denver Seattle Ctr Innovat Vet Ctr & Value Driven, Hlth Serv Res & Dev, Seattle, WA USA. [Williams, Emily C.] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Seattle, WA 98195 USA. [Bucholz, Kathleen K.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. [Bucholz, Kathleen K.] Washington Univ, Sch Med, Midwest Alcoholism Res Ctr, St Louis, MO USA. RP Glass, JE (reprint author), Univ Wisconsin, Sch Social Work, 1350 Univ Ave, Madison, WI 53706 USA. EM jglass2@wisc.edu FU National Institutes of Health under Ruth L. Kirschstein National Research Service [5T32 DA015035, 1F31AA021034]; VA Health Services Research Development [CDA 12-276]; National Institute of Mental Health [R25 MH080916-01A2]; Department of Veterans Affairs, Health Services Research & Development Service, Quality Enhancement Research Initiative (QUERI); National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse of the National Institute of Health [R01AA012460, P60AA011998, U01AA008401, R01AA017915, R01AA01 7444, R21AA020018, R01DA014363] FX We are grateful to Sean D. Kristjannson for consultations on the statistical analysis and the feedback that he provided on this work. Dr. Glass received support to conduct this project from the National Institutes of Health under Ruth L. Kirschstein National Research Service Awards 5T32 DA015035 and 1F31AA021034. Dr. Williams is supported by a Career Development Award from VA Health Services Research & Development (CDA 12-276) and is an investigator with the Implementation Research Institute (IRI) at the George Warren Brown School of Social Work at Washington University in St. Louis. IRI is supported through an award from the National Institute of Mental Health (R25 MH080916-01A2) and the Department of Veterans Affairs, Health Services Research & Development Service, Quality Enhancement Research Initiative (QUERI). For the research reported in this publication, KKB was supported by the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse of the National Institute of Health under award numbers R01AA012460, P60AA011998, U01AA008401, R01AA017915, R01AA01 7444, R21AA020018, and R01DA014363. NR 50 TC 6 Z9 6 U1 4 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 IS 6 BP 1697 EP 1705 DI 10.1111/acer.12422 PG 9 WC Substance Abuse SC Substance Abuse GA AJ2SI UT WOS:000337511400025 PM 24848495 ER PT J AU Schmidt, TP Pennington, DL Durazzo, TC Meyerhoff, DJ AF Schmidt, Thomas P. Pennington, David L. Durazzo, Timothy C. Meyerhoff, Dieter J. TI Postural Stability in Cigarette Smokers and During Abstinence from Alcohol SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Ataxia; Balance; Postural Stability; Alcohol Dependence; Cigarette Smoking; Abstinence ID CROSS-SECTIONAL ANALYSIS; GRAY-MATTER VOLUMES; SHORT-TERM RECOVERY; ATAXIA TEST BATTERY; NEUROCOGNITIVE RECOVERY; NICOTINE DEPENDENCE; MAGNETIC-RESONANCE; GAIT DISTURBANCES; MAJOR DEPRESSION; BRAIN STRUCTURE AB Background Static postural instability is common in alcohol-dependent individuals (ALC). Chronic alcohol consumption has deleterious effects on the neural and perceptual systems subserving postural stability. However, little is known about the effects of chronic cigarette smoking on postural stability and its changes during abstinence from alcohol. Methods A modified Fregly ataxia battery was administered to a total of 115 smoking (sALC) and nonsmoking ALC (nsALC) and to 71 smoking (sCON) and nonsmoking light/nondrinking controls (nsCON). Subgroups of abstinent ALC were assessed at 3 time points (TPs; approximately 1, 5, 34weeks of abstinence from alcohol); a subset of nsCON was retested at 40weeks. We tested whether cigarette smoking affects postural stability in CON and in ALC during extended abstinence from alcohol, and we used linear mixed effects modeling to measure change across TPs within ALC. Results Chronic smoking was associated with reduced performance on the Sharpened Romberg eyes-closed task in abstinent ALC at all 3 TPs and in CON. The test performance of nsALC increased significantly between 1 and 32weeks of abstinence, whereas the corresponding increases for sALC between 1 and 35weeks were nonsignificant. With long-term abstinence from alcohol, nsALC recovered into the range of nsCON and sALC recovered into the range of sCON. Static postural stability decreased with age and correlated with smoking variables but not with drinking measures. Conclusions Chronic smoking was associated with reduced static postural stability with eyes closed and with lower increases of postural stability during abstinence from alcohol. Smoking cessation in alcohol dependence treatment may facilitate recovery from static postural instability during abstinence. C1 [Schmidt, Thomas P.; Pennington, David L.; Durazzo, Timothy C.; Meyerhoff, Dieter J.] San Francisco VA Med Ctr, CIND, San Francisco, CA 94121 USA. [Schmidt, Thomas P.; Pennington, David L.; Durazzo, Timothy C.; Meyerhoff, Dieter J.] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA. RP Schmidt, TP (reprint author), San Francisco VA Med Ctr, Ctr Imaging Neurodegenerat Dis 114M, 4150 Clement St, San Francisco, CA 94121 USA. EM thomas.schmidt@ucsf.edu FU National Institutes of Health [AA10788, DA24136] FX This work was supported by grants from the National Institutes of Health [AA10788 to DJM.; DA24136 to TCD] administered by the Northern California Institute for Research and Education, and by the use of resources and facilities at the San Francisco Veterans Administration Medical Center. We thank Mary Rebecca Young, Kathleen Altieri, Ricky Chen, and Drs. Peter Banys, Steven Batki, and Ellen Herbst of the Veterans Administration Substance Abuse Day Hospital, and Dr. David Pating, Karen Moise, and their colleagues at the Kaiser Permanente Chemical Dependency Recovery Program in San Francisco for their valuable assistance in recruiting participants. We also wish to extend our gratitude to the study participants, who made this research possible. NR 54 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 IS 6 BP 1753 EP 1760 DI 10.1111/acer.12409 PG 8 WC Substance Abuse SC Substance Abuse GA AJ2SI UT WOS:000337511400032 PM 24721012 ER PT J AU Harvey, PD Siever, LJ Huang, GD Muralidhar, S Zhao, HY Miller, P Aslan, M Mane, S McNamara, M Gleason, T Brophy, M Przygodszki, R O'Leary, TJ Gaziano, M Concato, J AF Harvey, Philip D. Siever, Larry J. Huang, Grant D. Muralidhar, Sumitra Zhao, Hongyu Miller, Perry Aslan, Mihaela Mane, Shrikant McNamara, Margaret Gleason, Theresa Brophy, Mary Przygodszki, Ronald O'Leary, Timothy J. Gaziano, Michael Concato, John TI The Genetics of Functional Disability in Schizophrenia and Bipolar Illness: Methods and Initial Results for VA Cooperative Study #572 SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS LA English DT Article DE schizophrenia; bipolar; genetics; neurocognition; disability ID CONSENSUS COGNITIVE BATTERY; MENTAL-ILLNESS; UNITED-STATES; I DISORDER; CONSORTIUM; ENDOPHENOTYPES; IMPAIRMENT; PREDICTION; STABILITY; CANDIDATE AB Given the prominence of cognitive impairments and disability associated with schizophrenia and bipolar disorder, substantial interest has arisen in identifying determinants of the diseases and their features. Genetic variation has been linked to skills that underlie disability ("functional capacity" or FC), highlighting need for understanding of these relationships. We describe the design and methods of a large, multisite, observational study focusing on the genetics of functional disability in schizophrenia and bipolar disorder, presenting initial data on recruitment, and characterization of the sample. Known as Veterans Affairs (VA) Cooperative Studies Program (CSP)#572, this study is recruiting, diagnosing, and assessing U.S. Veterans with either schizophrenia or bipolar I disorder. Assessments include neuropsychological (NP) testing, FC, suicidality, and co-morbid conditions such as posttraumatic stress disorder (PTSD). A sample of "psychiatrically healthy" Veterans from another project serves as a comparison group. An interim total of 8,140 participants (42.1% schizophrenia) have been recruited and assessed as of September 30, 2013, with 9 months of enrollment remaining and with a target sample size of 9,500. Veterans with schizophrenia were more likely to never have married, whereas lifetime PTSD and suicidality were more common in the bipolar veterans. Performance on the FC measures and NP tests was consistent with previous results, with mean t-scores of 35 (-1.5 SD) for schizophrenia and 41 (-0.9 SD) for the bipolar Veterans. This large population is representative of previous studies in terms of patient performance and co-morbidities. Subsequent genomic analyses will examine the genomic correlates of performance-based measures. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. C1 [Harvey, Philip D.] Bruce W Carter Miami Vet Affairs VA Med Ctr, Miami, FL USA. [Harvey, Philip D.] Univ Miami, Sch Med, Miami, FL 33136 USA. [Siever, Larry J.; McNamara, Margaret] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. [Siever, Larry J.; McNamara, Margaret] Mt Sinai Sch Med, New York, NY USA. [Huang, Grant D.; Muralidhar, Sumitra; Gleason, Theresa; Przygodszki, Ronald; O'Leary, Timothy J.] Vet Hlth Adm, Off Res & Dev, Washington, DC USA. [Zhao, Hongyu; Miller, Perry; Aslan, Mihaela; Concato, John] VA Connecticut Healthcare Syst, CERC, West Haven, CT USA. [Zhao, Hongyu; Miller, Perry; Aslan, Mihaela; Mane, Shrikant; Concato, John] Yale Univ, Sch Med, New Haven, CT USA. [Brophy, Mary; Gaziano, Michael] MAVERIC, Jamaica Plain, MA USA. [Brophy, Mary] Boston Univ, Sch Med, Boston, MA 02118 USA. [Gaziano, Michael] Harvard Univ, Boston, MA 02115 USA. RP Harvey, PD (reprint author), Univ Miami, Miller Sch Med, 1120 NW 14th St,Suite 1450, Miami, FL 33136 USA. EM pharvey@med.miami.edu OI Przygodzki, Ronald/0000-0002-1238-262X FU Department of Veterans Affairs Cooperative Studies Program FX Grant sponsor: Department of Veterans Affairs Cooperative Studies Program. NR 36 TC 10 Z9 10 U1 8 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4841 EI 1552-485X J9 AM J MED GENET B JI Am. J. Med. Genet. B PD JUN PY 2014 VL 165 IS 4 BP 381 EP 389 DI 10.1002/ajmg.b.32242 PG 9 WC Genetics & Heredity; Psychiatry SC Genetics & Heredity; Psychiatry GA AJ4UX UT WOS:000337674600012 PM 24798943 ER PT J AU Molnar, AO Parikh, CR Coca, SG Thiessen-Philbrook, H Koyner, JL Shlipak, MG Myers, ML Garg, AX AF Molnar, Amber O. Parikh, Chirag R. Coca, Steven G. Thiessen-Philbrook, Heather Koyner, Jay L. Shlipak, Michael G. Myers, Mary Lee Garg, Amit X. CA TRIBE-AKI Consortium TI Association Between Preoperative Statin Use and Acute Kidney Injury Biomarkers in Cardiac Surgical Procedures SO ANNALS OF THORACIC SURGERY LA English DT Article ID ACUTE-RENAL-FAILURE; ISCHEMIA-REPERFUSION INJURY; URINARY BIOMARKERS; SURGERY; THERAPY; RISK; OUTCOMES; BYPASS; PRAVASTATIN; DEFINITION AB Background. Acute kidney injury (AKI) is a serious complication of cardiac operations for which there remains no specific therapy. Animal data and several observational studies suggest that statins prevent AKI, but the results are not conclusive, and many studies are retrospective in nature. Methods. We conducted a multicenter prospective cohort study of 625 adult patients undergoing elective cardiac operations. All patients were taking statins and were grouped according to whether statins were continued or held in the 24 hours before operation. The primary outcome was AKI as defined by a doubling of serum creatinine or dialysis. The secondary outcome was the peak level of several kidney injury biomarkers. The results were adjusted for demographic and clinical factors. Results. Continuing(vs holding) a statin before operation was not associated with a lower risk of AKI, as defined by a doubling of serum creatinine or dialysis (adjusted relative risk [RR] 1.09; 95% confidence interval [CI] 0.44, 2.70). However, continuing a statin was associated with a lower risk of elevation of the following AKI biomarkers: urine interleukin-18, urine neutrophil gelatinase-associated lipocalin, urine kidney injury molecule-1, and plasma neutrophil gelatinase-associated lipocalin (adjusted RR 0.34; 95% CI 0.18, 0.62), (adjusted RR 0.41; 95% CI 0.22, 0.76), (adjusted RR 0.37; 95% CI 0.20, 0.76), (adjusted RR 0.62; 95% CI 0.39, 0.98), respectively. Conclusions. Statins may prevent kidney injury after cardiac operations, as evidenced by lower levels of kidney injury biomarkers. (c) 2014 by The Society of Thoracic Surgeons C1 Univ Ottawa, Dept Med, Div Nephrol, Ottawa, ON, Canada. Yale Univ, Sch Med, Nephrol Sect, Vet Affairs CT Healthcare Syst, New Haven, CT USA. Yale Univ, Program Appl Translat Res, New Haven, CT USA. Vet Affairs Med Ctr, Dept Med, West Haven, CT USA. Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada. Univ Chicago, Pritzker Sch Med, Dept Med, Nephrol Sect, Chicago, IL 60637 USA. Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, Div Gen Internal Med, San Francisco, CA 94143 USA. Univ Western Ontario, Div Cardiac Surg, London, ON, Canada. McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada. Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada. Inst Clin Evaluat Sci, Toronto, ON, Canada. RP Parikh, CR (reprint author), Yale Univ, Nephrol Sect, 950 Campbell Ave,Mail Code 151B,Bldg 35 A,Rm 219, West Haven, CT 06516 USA. EM chirag.parikh@yale.edu FU NIH [RO1HL085757, K24DK090203]; TRIBE-AKI Consortium; National Institutes of Health [K23DK080132, R01DK096549, R01HL085757]; Acute Kidney Injury (ASSESS-AKI) Consortium [U01DK082185] FX This study was supported by the NIH grant RO1HL085757 (CRP) to fund the TRIBE-AKI Consortium to study novel biomarkers of acute kidney injury in cardiac surgery. S.G.C. is supported by National Institutes of Health Grants K23DK080132, R01DK096549, and R01HL085757. C.R.P. is also supported by NIH grant K24DK090203. S.G.C., A.X.G., and C.R.P. are also members of the NIH-sponsored ASsess, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Consortium (U01DK082185). The urine biomarker assays were donated by Abbott Diagnostics (IL-18 and NGAL) and Sekisui Diagnostics, LLC (KIM-1 and L-FABP). The granting agencies, Abbott Diagnostics and Sekisui Diagnostics, Inc, did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. NR 40 TC 17 Z9 17 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-4975 EI 1552-6259 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD JUN PY 2014 VL 97 IS 6 BP 2081 EP 2088 DI 10.1016/j.athoracsur.2014.02.033 PG 9 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA AI9KT UT WOS:000337252200032 PM 24725831 ER PT J AU Domsic, RT Nihtyanova, SI Wisniewski, SR Fine, MJ Lucas, M Kwoh, CK Denton, CP Medsger, TA AF Domsic, Robyn T. Nihtyanova, Svetlana I. Wisniewski, Stephen R. Fine, Michael J. Lucas, Mary Kwoh, C. Kent Denton, Christopher P. Medsger, Thomas A., Jr. TI Derivation and Validation of a Prediction Rule for Two-Year Mortality in Early Diffuse Cutaneous Systemic Sclerosis SO ARTHRITIS & RHEUMATOLOGY LA English DT Article ID CLINICAL-PREDICTION; SCLERODERMA; SURVIVAL; FEATURES; DEATH; EMPHASIS; DISEASE; COHORT; MODEL AB Objective. Systemic sclerosis (SSc) is associated with a reduction in life expectancy, but there are no validated prognostic models for determining short-term mortality. The objective of this study was to derive and validate a prediction rule for 2-year mortality in patients with early diffuse cutaneous SSc (dcSSc). Methods. We studied a prospectively enrolled cohort of 387 US Caucasian patients with early dcSSc (<2 years from the appearance of the first symptom), randomly divided into a derivation cohort (n = 260) and a validation cohort (n = 127). Predefined baseline predictor variables were analyzed in a stepwise multi-variable logistic regression model in order to identify factors independently associated with 2-year all-cause mortality using a cutoff of P < 0.05. We rounded the beta values to the nearest integer and summed the points assigned to each variable in order to stratify patients into low-risk, moderate-risk, and high-risk groups. We then applied this rule to an external validation cohort of 110 Caucasian patients with early dcSSc from a single UK center and compared stratum-specific mortality using chi-square statistics. Results. Four independent predictor variables (with assigned integer values) comprised the model: age at first visit (points allotted: -1, 0, or 1), skin thickness progression rate (points allotted: 0 or 1), gastrointestinal tract severity (points allotted: 0, 1, or 2), and anemia (points allotted: 0 or 2). The prediction model performed well, with no significant differences between the derivation cohort and the US or UK validation cohorts in the low-risk and moderate-risk groups. Conclusion. We derived a 4-variable prediction rule that can be used to stratify patients with early dcSSc into groups by risk of 2-year mortality, and we validated that prediction rule in US and UK cohorts. C1 [Domsic, Robyn T.; Wisniewski, Stephen R.; Fine, Michael J.; Lucas, Mary; Kwoh, C. Kent; Medsger, Thomas A., Jr.] Univ Pittsburgh, Pittsburgh, PA 15261 USA. [Nihtyanova, Svetlana I.; Denton, Christopher P.] UCL, Sch Med, Royal Free Hosp, London W1N 8AA, England. [Fine, Michael J.; Kwoh, C. Kent] Vet Affairs Pittsburgh Healthcare, Vet Affairs Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. RP Domsic, RT (reprint author), Univ Pittsburgh, S724 Biomed Sci Tower,3500 Terrace St, Pittsburgh, PA 15261 USA. EM rtd4@pitt.edu OI Wisniewski, Stephen/0000-0002-3877-9860 FU NIH (from the National Institute of Arthritis and Musculoskeletal and Skin Diseases) [K23-AR-057845] FX Dr. Domsic's work was supported by the NIH (grant K23-AR-057845 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases). NR 34 TC 9 Z9 9 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD JUN PY 2014 VL 66 IS 6 BP 1616 EP 1624 DI 10.1002/art.38381 PG 9 WC Rheumatology SC Rheumatology GA AJ0SL UT WOS:000337366200024 PM 24470430 ER PT J AU Sher, L Braquehais, MD AF Sher, Leo Dolores Braquehais, Maria TI Suicidal behavior in military veterans and health care professionals SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY LA English DT Letter ID MORTALITY C1 [Sher, Leo] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. [Sher, Leo] James J Peters Vet Adm, Med Ctr, New York, NY USA. [Dolores Braquehais, Maria] Galatea Fdn, Coll Metges Barcelona, Galatea Clin, Integral Care Program Sick Doctors, Barcelona, Spain. [Dolores Braquehais, Maria] Univ Autonoma Barcelona, Vail dHebron Univ Hosp, Dept Psychiat & Legal Med, CIBERSAM, E-08193 Barcelona, Spain. RP Sher, L (reprint author), Icahn Sch Med Mt Sinai, James J Peters Vet Adm, Med Ctr, 130 West Kingsbridge Rd, Bronx, NY 10468 USA. EM DrLeoSher@gmail.com NR 3 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0004-8674 EI 1440-1614 J9 AUST NZ J PSYCHIAT JI Aust. N. Z. J. Psych. PD JUN PY 2014 VL 48 IS 6 BP 589 EP 589 DI 10.1177/0004867413517761 PG 1 WC Psychiatry SC Psychiatry GA AJ4RE UT WOS:000337662700020 PM 24366856 ER PT J AU Wiener, RS Ouellette, DR Diamond, E Fan, VS Maurer, JR Mularski, RA Peters, JI Halpern, SD AF Wiener, Renda Soylemez Ouellette, Daniel R. Diamond, Edward Fan, Vincent S. Maurer, Janet R. Mularski, Richard A. Peters, Jay I. Halpern, Scott D. TI An Official American Thoracic Society/American College of Chest Physicians Policy Statement SO CHEST LA English DT Article ID PULMONARY ARTERIAL-HYPERTENSION; CLINICAL-PRACTICE GUIDELINES; SYSTOLIC HEART-FAILURE; LUNG-CANCER DIAGNOSIS; COMPUTED-TOMOGRAPHY; PATIENT COMMUNICATION; EMERGENCY-DEPARTMENT; EXERCISE CAPACITY; DECISION-ANALYSIS; CONTROLLED-TRIAL AB The American Board of Internal Medicine Foundation's Choosing Wisely campaign aims to curb health-care costs and improve patient care by soliciting lists from medical societies of the top five tests or treatments in their specialty that are used too frequently and inappropriately. The American Thoracic Society (ATS) and American College of Chest Physicians created a joint task force, which produced a top five list for adult pulmonary medicine. Our top five recommendations, which were approved by the executive committees of the ATS and American College of Chest Physicians and published by Choosing Wisely in October 2013, are as follows: (1) Do not perform CT scan surveillance for evaluation of indeterminate pulmonary nodules at more frequent intervals or for a longer period of time than recommended by established guidelines; (2) do not routinely offer pharmacologic treatment with advanced vasoactive agents approved only for the management of pulmonary arterial hypertension to patients with pulmonary hypertension resulting from left heart disease or hypoxemic lung diseases (groups II or III pulmonary hypertension); (3) for patients recently discharged on supplemental home oxygen following hospitalization for an acute illness, do not renew the prescription without assessing the patient for ongoing hypoxemia; (4) do not perform chest CT angiography to evaluate for possible pulmonary embolism in patients with a low clinical probability and negative results of a highly sensitive D-dimer assay; (5) do not perform CT scan screening for lung cancer among patients at low risk for lung cancer. We hope pulmonologists will use these recommendations to stimulate frank discussions with patients about when these tests and treatments are indicated-and when they are not. C1 [Wiener, Renda Soylemez] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA. [Wiener, Renda Soylemez] Edith Nourse Rogers Mem Vet Hosp, Ctr Healthcare Org & Implementat Res, Bedford, MA USA. [Wiener, Renda Soylemez] Dartmouth Inst Hlth Policy & Clin Practice, Hanover, NH USA. [Ouellette, Daniel R.] Henry Ford Hlth Syst, Detroit, MI USA. [Diamond, Edward] Suburban Lung Associates, Elk Grove Village, IL USA. [Fan, Vincent S.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Fan, Vincent S.] Univ Washington, Dept Med, Seattle, WA USA. [Maurer, Janet R.] Univ Arizona, Coll Med, Dept Med, Phoenix, AZ USA. [Maurer, Janet R.] Magellan Hlth Serv Inc, Natl Imaging Associates, Qual Improvement & Compliance, Phoenix, AZ USA. [Mularski, Richard A.] Kaiser Permanente Northwest, Ctr Hlth Res, Portland, OR USA. [Mularski, Richard A.] Northwest Permanente PC, Dept Pulm Crit Care Med, Portland, OR USA. [Mularski, Richard A.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA. [Peters, Jay I.] UT Hlth Sci Ctr, San Antonio, TX USA. [Peters, Jay I.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Halpern, Scott D.] Univ Penn, Dept Med, Ctr Hlth Incent & Behav Econ, Philadelphia, PA 19104 USA. [Halpern, Scott D.] Univ Penn, Dept Biostat & Epidemiol, Ctr Hlth Incent & Behav Econ, Philadelphia, PA 19104 USA. [Halpern, Scott D.] Univ Penn, Dept Med Eth & Hlth Policy, Ctr Hlth Incent & Behav Econ, Philadelphia, PA 19104 USA. [Halpern, Scott D.] Univ Penn, Leonard Davis Inst, Ctr Hlth Incent & Behav Econ, Philadelphia, PA 19104 USA. RP Wiener, RS (reprint author), Ctr Pulm, 72 E Concord St,R-304, Boston, MA 02118 USA. EM rwiener@bu.edu OI Wiener, Renda/0000-0001-7712-2135 FU NCI NIH HHS [K07 CA138772] NR 79 TC 13 Z9 14 U1 0 U2 6 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD JUN PY 2014 VL 145 IS 6 BP 1383 EP 1391 DI 10.1378/chest.14-0670 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AJ0OV UT WOS:000337355600032 PM 24889436 ER PT J AU Fan, VS Meek, PM AF Fan, Vincent S. Meek, Paula M. TI Anxiety, Depression, and Cognitive Impairment in Patients with Chronic Respiratory Disease SO CLINICS IN CHEST MEDICINE LA English DT Article DE Anxiety; Depression; Cognitive impairment; Chronic respiratory disease ID OBSTRUCTIVE PULMONARY-DISEASE; RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; STATE WORRY QUESTIONNAIRE; WORKING-MEMORY; COPD PATIENTS; PRIMARY-CARE; PSYCHOMETRIC PROPERTIES; REHABILITATION PROGRAM; ARTERIAL-HYPERTENSION AB In this article, the prevalence of depression, anxiety, and cognitive impairment in persons with chronic obstructive pulmonary disease, and the impact of these psychological and cognitive factors on clinical outcomes in COPD is reviewed. Methods for screening and identification of these conditions in COPD are described. The extent to which depression, anxiety or cognitive impairment limit or modify the effectiveness of pulmonary rehabilitation, and whether pulmonary rehabilitation may ameliorate these psychological and cognitive impairments are discussed. C1 [Fan, Vincent S.] Univ Washington, Dept Med, Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA 98105 USA. [Meek, Paula M.] Univ Colorado, Coll Nursing, Boulder, CO 80309 USA. RP Fan, VS (reprint author), Univ Washington, Dept Med, Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA 98105 USA. EM Vincent.fan@va.gov NR 85 TC 5 Z9 5 U1 2 U2 23 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-5231 EI 1557-8216 J9 CLIN CHEST MED JI Clin. Chest Med. PD JUN PY 2014 VL 35 IS 2 BP 399 EP + DI 10.1016/j.ccm.2014.02.012 PG 12 WC Respiratory System SC Respiratory System GA AJ5ZL UT WOS:000337769400013 PM 24874134 ER PT J AU Tripathy, D Clement, SC Schwenke, DC Banerji, M Bray, GA Buchanan, TA Gastaldelli, A Henry, RR Kitabchi, AE Mudaliar, S Ratner, RE Stentz, FB Musi, N Reaven, PD DeFronzo, RA AF Tripathy, Devjit Clement, Stephen C. Schwenke, Dawn C. Banerji, MaryAnn Bray, George A. Buchanan, Thomas A. Gastaldelli, Amalia Henry, Robert R. Kitabchi, Abbas E. Mudaliar, Sunder Ratner, Robert E. Stentz, Frankie B. Musi, Nicolas Reaven, Peter D. DeFronzo, Ralph A. TI Baseline Adiponectin Levels Do Not Influence the Response to Pioglitazone in ACT NOW SO DIABETES CARE LA English DT Article ID TYPE-2 DIABETES-MELLITUS; ACTIVATED PROTEIN-KINASE; PPAR-GAMMA AGONISTS; INSULIN SENSITIVITY; GLUCOSE; RESISTANCE; EXPRESSION; PREVENTION; OXIDATION; INDEX AB OBJECTIVE Plasma adiponectin levels are reduced in type 2 diabetes mellitus (T2DM) and other insulin-resistant states. We examined whether plasma adiponectin levels at baseline and after pioglitazone treatment in impaired glucose tolerance (IGT) subjects were associated with improved insulin sensitivity (Si) and glucose tolerance status. RESEARCH DESIGN AND METHODS A total of 602 high-risk IGT subjects in ACT NOW were randomized to receive pioglitazone or placebo with a median follow-up of 2.4 years. RESULTS Pioglitazone reduced IGT conversion to diabetes by 72% in association with improved n-cell function by 64% (insulin secretion/insulin resistance index) and increased tissue sensitivity by 88% (Matsuda index). In pioglitazone-treated subjects, plasma adiponectin concentration increased threefold from 13 +/- 0.5 to 38 +/- 2.5 mu g/mL (P < 0.001) and was strongly correlated with the improvement in SI (r = 0.436, P < 0.001) and modestly correlated with glucose area under the curve during oral glucose tolerance test (r = 0.238, P < 0.005) and insulin secretion/insulin resistance index (r = 0.306, P < 0.005). The increase in adiponectin was a strong predictor of reversion to normal glucose tolerance and prevention of T2DM. In the placebo group, plasma adiponectin did not change and was not correlated with changes in glucose levels. There was an inverse association between baseline plasma adiponectin concentration and progression to diabetes in the placebo group but not in the pioglitazone group. CONCLUSIONS Baseline adiponectin does not predict the response to pioglitazone. The increase in plasma adiponectin concentration after pioglitazone therapy in IGT subjects is strongly related to improved glucose tolerance status and enhanced tissue sensitivity to insulin. C1 [Tripathy, Devjit; Musi, Nicolas; DeFronzo, Ralph A.] Texas Diabet Inst, San Antonio, TX 78207 USA. [Tripathy, Devjit; Gastaldelli, Amalia; Musi, Nicolas; DeFronzo, Ralph A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Tripathy, Devjit; Musi, Nicolas; DeFronzo, Ralph A.] South Texas VA Hlth Care Syst, Audie L Murphy Hosp, San Antonio, TX USA. [Clement, Stephen C.] Georgetown Univ, Div Endocrinol & Metab, Washington, DC USA. [Schwenke, Dawn C.; Reaven, Peter D.] Phoenix VA Hlth Care Syst, Phoenix, AZ USA. [Schwenke, Dawn C.] Arizona State Univ, Coll Nursing & Hlth Innovat, Phoenix, AZ USA. [Banerji, MaryAnn] SUNY Hlth Sci Ctr, Brooklyn, NY USA. [Bray, George A.] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70803 USA. [Buchanan, Thomas A.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Gastaldelli, Amalia] CNR, Inst Clin Physiol, Cardiometab Risk Unit, I-56100 Pisa, Italy. [Henry, Robert R.; Mudaliar, Sunder] VA San Diego Healthcare Syst, San Diego, CA USA. [Henry, Robert R.; Mudaliar, Sunder] Univ Calif San Diego, San Diego, CA 92103 USA. [Kitabchi, Abbas E.; Stentz, Frankie B.] Univ Tennessee, Div Endocrinol Diabet & Metab, Memphis, TN USA. [Ratner, Robert E.] Medstar Res Inst, Hyattsville, MD USA. RP DeFronzo, RA (reprint author), Texas Diabet Inst, San Antonio, TX 78207 USA. EM albarado@uthscsa.edu RI Gastaldelli, Amalia/H-3319-2014 OI Gastaldelli, Amalia/0000-0003-2594-1651 FU General Clinical Research Center at the University of Tennessee Health Science Center, Clinical and Translational Science Award [M01-RR-00221, UL1-TR-000130]; South Texas Veterans Health Care System-Audie Murphy Division; Veterans Administration Health Care System FX This study was supported in part by General Clinical Research Center grant M01-RR-00221 at the University of Tennessee Health Science Center, Clinical and Translational Science Award grant UL1-TR-000130 to the University of Southern California, and the South Texas Veterans Health Care System-Audie Murphy Division. Part (five-eighths) of R.A.D.'s salary is supported by the Veterans Administration Health Care System. Takeda Pharmaceuticals North America provided the study drug. NR 22 TC 2 Z9 2 U1 0 U2 3 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD JUN PY 2014 VL 37 IS 6 BP 1706 EP 1711 DI 10.2337/dc13-1745 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AJ5RX UT WOS:000337746100048 PM 24705615 ER PT J AU Mentz, RJ Cotter, G Cleland, JGF Stevens, SR Chiswell, K Davison, BA Teerlink, JR Metra, M Voors, AA Grinfeld, L Ruda, M Mareev, V Lotan, C Bloomfield, DM Fiuzat, M Givertz, MM Ponikowski, P Massie, BM O'Connor, CM AF Mentz, Robert J. Cotter, Gad Cleland, John G. F. Stevens, Susanna R. Chiswell, Karen Davison, Beth A. Teerlink, John R. Metra, Marco Voors, Adriaan A. Grinfeld, Liliana Ruda, Mikhail Mareev, Viacheslav Lotan, Chaim Bloomfield, Daniel M. Fiuzat, Mona Givertz, Michael M. Ponikowski, Piotr Massie, Barry M. O'Connor, Christopher M. TI International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short-term outcomes in patients enrolled in Eastern Europe and Russia in the PROTECT trial SO EUROPEAN JOURNAL OF HEART FAILURE LA English DT Article DE Acute heart failure; Length of stay; Trial; Regional differences; Global variation; Outcomes ID ACUTE MYOCARDIAL-INFARCTION; QUALITY-OF-CARE; VASOPRESSIN ANTAGONISM; HOSPITAL READMISSION; EVEREST EFFICACY; SURVEY PROGRAM; RATES; SURVIVAL; TRENDS; HF AB AimsThe implications of geographical variation are unknown following adjustment for hospital length of stay (LOS) in heart failure (HF) trials that included patients whether or not they had systolic dysfunction. We investigated regional differences in an international acute HF trial. Methods and resultsThe PROTECT trial investigated 2033 patients with acute HF and renal dysfunction hospitalized at 173 sites in 17 countries with randomization to rolofylline or placebo. We grouped enrolling countries into six regions. Baseline characteristics, in-hospital management, and outcomes were explored by region. The primary study outcome was 60-day mortality or cardiovascular/renal hospitalization. Secondary outcomes included 180-day mortality. Of 2033 patients, 33% were from Eastern Europe, 19% from Western Europe, 16% from Israel, 15% from North America, 14% from Russia, and 3% from Argentina. Marked differences in baseline characteristics, HF phenotype, in-hospital diuretic and vasodilator strategies, and LOS were observed by region. LOS was shortest in North America and Israel (median 5 days) and longest in Russia (median 15 days). Regional event rates varied significantly. Following multivariable adjustment, region was an independent predictor of the risk of mortality/hospitalization at 60 days, with the lowest risk in Russia (hazard ratio 0.39, 95% confidence interval 0.23-0.64 vs. Western Europe) due to lower rehospitalization; mortality differences were attenuated by 180 days. ConclusionsIn an international HF trial, there were differences in baseline characteristics, treatments, LOS, and rehospitalization amongst regions, but little difference in longer term mortality. Rehospitalization differences exist independent of LOS. This analysis may help inform future trial design and should be externally validated. C1 [Mentz, Robert J.; Fiuzat, Mona; O'Connor, Christopher M.] Duke Univ, Durham, NC 27710 USA. [Cotter, Gad; Davison, Beth A.] Momentum Res Inc, Durham, NC USA. [Cleland, John G. F.] Univ Hull, Kingston Upon Hull, Yorks, England. [Stevens, Susanna R.; Chiswell, Karen] Duke Clin Res Inst, Durham, NC USA. [Teerlink, John R.; Massie, Barry M.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Teerlink, John R.; Massie, Barry M.] San Francisco VA Med Ctr, San Francisco, CA USA. [Metra, Marco] Univ Brescia, Brescia, Italy. [Voors, Adriaan A.] Univ Groningen, Groningen, Netherlands. [Grinfeld, Liliana] Univ Buenos Aires, Buenos Aires, DF, Argentina. [Ruda, Mikhail] Cardiol Res Ctr, Moscow 121552, Russia. [Mareev, Viacheslav] Russian Acad Med Sci, Cardiol Sci Ctr, Inst Clin Cardiol, Moscow, Russia. [Lotan, Chaim] Hadassah Med Org Ein Karem, Jerusalem, Israel. [Bloomfield, Daniel M.] Merck Res Labs, Rahway, NJ USA. [Givertz, Michael M.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Ponikowski, Piotr] Med Univ, Clin Mil Hosp, Wroclaw, Poland. RP Mentz, RJ (reprint author), Duke Univ, Med Ctr, 2301 Erwin Rd, Durham, NC 27710 USA. EM robert.mentz@duke.edu RI Ponikowski, Piotr/O-6454-2015 OI Ponikowski, Piotr/0000-0002-3391-7064; Mareev, Vyacheslav Yurievich/0000-0002-7285-2048; Metra, Marco/0000-0001-6691-8568; Davison, Beth/0000-0003-2374-6449; Cleland, John/0000-0002-1471-7016 FU NIGMS NIH HHS [T32 GM086330] NR 26 TC 27 Z9 27 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1388-9842 EI 1879-0844 J9 EUR J HEART FAIL JI Eur. J. Heart Fail. PD JUN PY 2014 VL 16 IS 6 BP 614 EP 624 DI 10.1002/ejhf.92 PG 11 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AJ2FG UT WOS:000337470400006 PM 24771609 ER PT J AU Jhund, PS Claggett, B Packer, M Zile, MR Voors, AA Pieske, B Lefkowitz, M Shi, V Bransford, T McMurray, JJV Solomon, SD AF Jhund, Pardeep S. Claggett, Brian Packer, Milton Zile, Michael R. Voors, Adriaan A. Pieske, Burkert Lefkowitz, Martin Shi, Victor Bransford, Toni McMurray, John J. V. Solomon, Scott D. TI Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial SO EUROPEAN JOURNAL OF HEART FAILURE LA English DT Article DE Blood pressure; Heart failure; Neprilysin inhibitor; NT-proBNP; Preserved ejection fraction ID RANDOMIZED CONTROLLED-TRIAL; ATRIAL-NATRIURETIC-PEPTIDE; DIASTOLIC FUNCTION; CONVERTING ENZYME; RAT; OMAPATRILAT; MORTALITY; DIAGNOSIS AB AimsThe first in class angiotensin receptor neprilysin inhibitor, LCZ696 has been shown to reduce levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), reduce left atrial size and improve New York Heart Association (NYHA) class in patients with heart failure with preserved ejection fraction (HFpEF). We examined whether the effects of LCZ696 were independent of systolic blood pressure (SBP) lowering. Methods and resultsIn the Prospective comparison of ARNi (angiotensin receptor neprilysin inhibitor) with ARB (angiotensin receptor blocker) on Management Of heart failUre with preserved ejectioN fracTion (PARAMOUNT) trial 301 patients were randomly assigned to LCZ696 or valsartan. We examined the relationship between SBP lowering and LCZ696 on NT-proBNP level, left atrial size, NYHA class and estimated glomerular filtration rate (eGFR). By 12weeks blood pressure was reduced by 9mmHg (SD 15)/5mmHg (SD 11) in patients receiving LCZ696 in comparison with 3mmHg (SD 17)/2mmHg (SD 12) in those receiving valsartan. The change in NT-proBNP was poorly correlated with change in SBP (LCZ696, r=0.17, P=0.06; valsartan, r=0.05, P=0.58) After adjustment for change in SBP, the ratio of change in NT-proBNP at 12weeks for LCZ696 vs. valsartan was 0.76 (95% CI 0.63-0.93, P=0.008), and similar to the ratio not adjusting for SBP (0.76, 95% CI 0.63-0.92, P=0.006); P for interaction was 0.38). Similarly, reduction in left atrial volume index at 36weeks, improvement in NYHA class and eGFR were all independent of the change in SBP. ConclusionIn patients with HFpEF, the effect of the angiotensin receptor neprilysin inhibitor LCZ696 on NT-proBNP, left atrial volume, functional class, and eGFR was independent of reduction in SBP. C1 [Jhund, Pardeep S.; Claggett, Brian; Solomon, Scott D.] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA. [Jhund, Pardeep S.; McMurray, John J. V.] Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland. [Packer, Milton] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA. [Zile, Michael R.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. [Zile, Michael R.] Med Univ S Carolina, Charleston, SC 29425 USA. [Voors, Adriaan A.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. [Pieske, Burkert] Med Univ Graz, Dept Cardiol, Graz, Austria. [Lefkowitz, Martin; Shi, Victor; Bransford, Toni] Novartis Pharmaceut, E Hanover, NJ USA. RP Solomon, SD (reprint author), Brigham & Womens Hosp, Div Cardiovasc, 75 Francis St, Boston, MA 02115 USA. EM ssolomon@rics.bwh.harvard.edu OI Jhund, Pardeep/0000-0003-4306-5317; mcmurray, john/0000-0002-6317-3975 NR 22 TC 27 Z9 30 U1 0 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1388-9842 EI 1879-0844 J9 EUR J HEART FAIL JI Eur. J. Heart Fail. PD JUN PY 2014 VL 16 IS 6 BP 671 EP 677 DI 10.1002/ejhf.76 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AJ2FG UT WOS:000337470400013 PM 24692284 ER PT J AU Schmittdiel, JA Dyer, W Uratsu, C Magid, DJ O'Connor, PJ Beck, A Butler, M Ho, MP Vazquez-Benitez, G Adams, AS AF Schmittdiel, Julie A. Dyer, Wendy Uratsu, Connie Magid, David J. O'Connor, Patrick J. Beck, Arne Butler, Melissa Ho, Michael P. Vazquez-Benitez, Gabriela Adams, Alyce S. TI Initial Persistence With Antihypertensive Therapies Is Associated With Depression Treatment Persistence, But Not Depression SO JOURNAL OF CLINICAL HYPERTENSION LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; MEDICATION ADHERENCE; UNITED-STATES; HYPERTENSIVE PATIENTS; SYSTEM FACTORS; HEART-DISEASE; BLACK-MEN; PREVALENCE; SYMPTOMS; TRENDS AB The purpose of this study was to examine the relationship between the presence of clinical depression and persistence to drug therapy treatment for depression with early nonpersistence to antihypertensive therapies in a large, diverse cohort of newly treated hypertension patients. Using a hypertension registry at Kaiser Permanente Northern California, the authors conducted a retrospective cohort study of 44,167 adults (18years and older) with hypertension who were new users of antihypertensive therapy in 2008. We used multivariate logistic regression analysis to model the relationships between the presence of clinical depression and early nonpersistence (defined as failing to refill the first prescription within 90days after the end of the first fill days' supply) to antihypertensive therapies, controlling for sociodemographic and clinical risk factors. Within the group of 1484 patients who had evidence of clinical depression in the 12months prior to the initiation of antihypertensive therapy, the authors examined the relationship between drug therapy treatment for depression and 6-month persistence with antidepressant therapy with early nonpersistence with antihypertensive therapies. No association was found between the presence of clinical depression and early nonpersistence to antihypertensive therapies after adjustment for individual demographic and clinical characteristics and neighborhood-level socioeconomic status. However, among the subset of 1484 patients with documented evidence of clinical depression in the 12months prior to the initiation of antihypertensive therapy, being prescribed and persistence with antidepressant therapy was strongly associated with lower odds of early nonpersistence to antihypertensive medications (odds ratio, 0.64; confidence interval, 0.42-0.96). In an integrated delivery system, the authors found that treatment for depression was associated with higher levels of antihypertensive persistence. Improving quality of depression care in patients with comorbid hypertension may be an important strategy in decreasing cardiovascular disease risk in these patients. C1 [Schmittdiel, Julie A.; Dyer, Wendy; Uratsu, Connie; Adams, Alyce S.] Kaiser Permanente, Div Res, Oakland, CA 94612 USA. [Magid, David J.; Beck, Arne; Ho, Michael P.] Kaiser Permanente, Inst Res, Denver, CO USA. [Magid, David J.; Ho, Michael P.] Univ Colorado, Denver, CO 80202 USA. [O'Connor, Patrick J.; Vazquez-Benitez, Gabriela] HealthPartners Res Fdn, Minneapolis, MN USA. [Butler, Melissa] Kaiser Permanente, Ctr Hlth Res Southeast, Atlanta, GA USA. [Ho, Michael P.] Denver VA Med Ctr, Denver, CO USA. RP Schmittdiel, JA (reprint author), Kaiser Permanente, Div Res, 2000 Broadway, Oakland, CA 94612 USA. EM Julie.A.Schmittdiel@kp.org FU National Heart, Lung, and Blood Institute [3U19HL091179-04S1]; National Institute for Mental Health; Health Delivery Systems Center for Diabetes Translational Research - National Institute for Diabetes, Digestive and Kidney Diseases [P30DK092924] FX This study was funded by [3U19HL091179-04S1] the National Heart, Lung, and Blood Institute and the National Institute for Mental Health as a supplement to the HMO Research Network Cardiovascular Disease Network. Additional support for Drs Adams, Schmittdiel, and OConnor was also provided by the Health Delivery Systems Center for Diabetes Translational Research [P30DK092924], funded by the National Institute for Diabetes, Digestive and Kidney Diseases. The funders had no role in the design or conduct of the study, data collection, management, analysis or interpretation, or in the preparation, review, or approval of this manuscript. The authors report no conflicts of interest. Dr Schmittdiel had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. NR 31 TC 2 Z9 2 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1524-6175 EI 1751-7176 J9 J CLIN HYPERTENS JI J. Clin. Hypertens. PD JUN PY 2014 VL 16 IS 6 BP 412 EP 417 DI 10.1111/jch.12300 PG 6 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AJ3XE UT WOS:000337600400007 PM 24716533 ER PT J AU Tang, VL Halm, EA Fine, MJ Johnson, CS Anzueto, A Mortensen, EM AF Tang, Victoria L. Halm, Ethan A. Fine, Michael J. Johnson, Christopher S. Anzueto, Antonio Mortensen, Eric M. TI Predictors of rehospitalization after admission for pneumonia in the veterans affairs healthcare system SO JOURNAL OF HOSPITAL MEDICINE LA English DT Article ID COMMUNITY-ACQUIRED PNEUMONIA; HOSPITAL ADMISSION; ELDERLY-PATIENTS; DISCHARGE; OUTCOMES; RISK; READMISSION; INSTABILITY; MORTALITY AB INTRODUCTION Although some factors associated with rehospitalization after community-acquired pneumonia have been identified, other factors such as medical care utilization and medication usage have not been previously studied. We investigated novel predictors of rehospitalization in patients admitted with pneumonia. METHODS Using Department of Veteran Affairs (VA) administrative data from October 2001 to September 2007, we examined a cohort of patients 65 years old and older, who were hospitalized with pneumonia, in 150 VA acute care hospitals. The cohort was randomly split into derivation and validation samples, and then logistic regression models were used to identify and validate predictors of all-cause rehospitalization within 30 days. RESULTS Of the 45,134 subjects, 13% were rehospitalized within 30 days. No significant differences were noted between the derivation and validation cohorts. Factors associated with readmission included age, marital status, chronic renal disease, prior malignancy, nursing home residence, congestive heart failure, use of oral corticosteroids, number of emergency department visits a year prior, prior admission, number of outpatient clinic visits in a year prior, and length of hospital stay. The C statistics for the derivation and validation models were 0.615 and 0.613, respectively. CONCLUSIONS Factors associated with readmission were largely unrelated to the underlying pneumonia, but were related to demographics, comorbidities, healthcare utilization, and length of stay on index admission. Journal of Hospital Medicine 2014;9:379-383. 2014 Society of Hospital Medicine C1 [Tang, Victoria L.; Johnson, Christopher S.; Mortensen, Eric M.] VA North Texas Hlth Care Syst, Div Gen Internal Med, Dallas, TX USA. [Tang, Victoria L.; Halm, Ethan A.; Johnson, Christopher S.; Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Div Gen Internal Med, Dallas, TX 75390 USA. [Fine, Michael J.] Univ Pittsburgh, VA Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. [Fine, Michael J.] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Fine, Michael J.] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA USA. [Anzueto, Antonio] South Texas Vet Hlth Care Syst, Div Pulm Dis & Crit Care Med, San Antonio, TX USA. [Anzueto, Antonio] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Mortensen, EM (reprint author), Dallas VA Med Ctr, 111E,4500 South Lancaster, Dallas, TX 75216 USA. EM eric.mortensen@UTSouthwestern.edu OI Mortensen, Eric/0000-0002-3880-5563 FU National Institute of Nursing Research [R01NR010828] FX The project described was supported by grant number R01NR010828 from the National Institute of Nursing Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Nursing Research or the National Institutes of Health. This material is the result of work supported with resources and the use of facilities at the VA North Texas Health Care System. Funding agencies had no role in conducting the study, or role in the preparation, review, or approval of the manuscript. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. NR 18 TC 3 Z9 4 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1553-5592 EI 1553-5606 J9 J HOSP MED JI J. Hosp. Med. PD JUN PY 2014 VL 9 IS 6 BP 379 EP 383 DI 10.1002/jhm.2184 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AJ2VK UT WOS:000337522100006 PM 24648401 ER PT J AU Lackey, AE Pandey, T Moshiri, M Lalwani, N Lall, C Bhargava, P AF Lackey, Amanda E. Pandey, Tarun Moshiri, Mariam Lalwani, Neeraj Lall, Chandana Bhargava, Puneet TI Productivity, Part 2: Cloud Storage, Remote Meeting Tools, Screencasting, Speech Recognition Software, Password Managers, and Online Data Backup SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Article DE Productivity; cloud applications; collaboration ID RADIOLOGY EDUCATION 2.0-ON; CUSP AB It is an opportune time for radiologists to focus on personal productivity. The ever increasing reliance on computers and the Internet has significantly changed the way we work. Myriad software applications are available to help us improve our personal efficiency. In this article, the authors discuss some tools that help improve collaboration and personal productivity, maximize e-learning, and protect valuable digital data. C1 [Lackey, Amanda E.; Pandey, Tarun] Univ Arkansas Med Sci, Dept Radiol, Little Rock, AR 72205 USA. [Moshiri, Mariam; Lalwani, Neeraj] Univ Washington, Sch Med, Dept Radiol, Seattle, WA 98195 USA. [Lall, Chandana] Univ Calif Irvine, Orange, CA 92668 USA. [Bhargava, Puneet] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. [Bhargava, Puneet] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. RP Bhargava, P (reprint author), Univ Washington, Mail Box 358280,S-114 Radiol,1660 S Columbian Way, Seattle, WA 98108 USA. EM bhargp@uw.edu RI Lalwani, Neeraj/A-3490-2011 OI Lalwani, Neeraj/0000-0001-5514-2805; Bhargava, Puneet/0000-0002-3849-9666 NR 27 TC 1 Z9 1 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD JUN PY 2014 VL 11 IS 6 BP 580 EP 588 DI 10.1016/j.jacr.2013.11.021 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AJ0HJ UT WOS:000337331000011 PM 24674716 ER PT J AU Germino, JC Rapp, EJ Hippe, DS Shah, AC McFall, ME Bhargava, P AF Germino, Jessica C. Rapp, Elliot J. Hippe, Daniel S. Shah, Anura C. McFall, Miles E. Bhargava, Puneet TI Assessing and Optimizing Imaging of Patients with Posttraumatic Stress Disorder SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Editorial Material ID CLAUSTROPHOBIA; ANXIETY; EXPERIENCES C1 [Germino, Jessica C.; Rapp, Elliot J.; Hippe, Daniel S.] Univ Washington, Dept Radiol, Seattle, WA 98108 USA. [Shah, Anura C.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Div, Dept Prevent & Management Disrupt Behav, Seattle, WA USA. [McFall, Miles E.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Div, Seattle, WA USA. [McFall, Miles E.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98108 USA. [Bhargava, Puneet] Univ Washington, Dept Radiol, Seattle, WA 98108 USA. [Bhargava, Puneet] VA Puget Hlth Care Syst, Seattle, WA 98108 USA. RP Bhargava, P (reprint author), Univ Washington, S-114 RAD,1660 S Columbian Way,Mail Box 358280, Seattle, WA 98108 USA. EM bhargp@uw.edu OI Bhargava, Puneet/0000-0002-3849-9666 NR 14 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD JUN PY 2014 VL 11 IS 6 BP 629 EP 631 DI 10.1016/j.jacr.2013.10.020 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AJ0HJ UT WOS:000337331000020 PM 24613448 ER PT J AU Makam, AN Boscardin, WJ Mao, YH Steinman, MA AF Makam, Anil N. Boscardin, W. John Mao, Yinghui Steinman, Michael A. TI Risk of Thiazide-Induced Metabolic Adverse Events in Older Adults SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE aged; adverse effects; sodium chloride symporter inhibitors; hypertension; outcome assessment (health care) ID INDUCED HYPONATREMIA; BLOOD-PRESSURE; SYSTOLIC HYPERTENSION; CARDIOVASCULAR EVENTS; ELDERLY PROGRAM; CLINICAL-TRIALS; DRUG-REACTIONS; DIURETICS; OUTCOMES; METAANALYSIS AB Objectives To evaluate the risk and predictors of thiazide-induced adverse events (AEs) in multimorbid older adults in real-world clinical settings. Design Observational cohort study. Setting National Veterans Affairs data from 2007 to 2008. Participants Veterans aged 65 and older newly prescribed a thiazide (N=1,060) compared with propensity-matched nonusers of antihypertensive medications (N=1,060). Measurements The primary outcome was a composite of metabolic AEs defined as sodium less than 135mEq/L, potassium less than 3.5mEq/L, or a decrease in the estimated glomerular filtration rate (eGFR) of more than 25% from the baseline rate. Secondary outcomes included sev-ere AEs (sodium <130mEq/L, potassium <3.0mEq/L, or a decrease in eGFR of more than 50%). Results Over 9months of follow-up, 14.3% of new thiazide users developed an AE, compared with 6.0% of nonusers (number needed to harm (NNH) 12, 95% confidence interval (CI)=9-17, P<.001); 1.8% of new users developed a severe AE, compared with 0.6% of nonusers (NNH=82, P=.008), and 3.8% of new users had an emergency department visit or hospitalization with an AE, compared with 2.0% of nonusers (NNH=56, P=.02). Risk of AEs did not vary according to age, but having five or more comorbidities was associated with 3.0 times the odds (95% CI=1.4-6.2) of developing an AE as having one comorbidity (hypertension). Low-normal and unmeasured baseline sodium and potassium values were among the strongest predictors of hyponatremia and hypokalemia, respectively. Only 42% of thiazide users had laboratory monitoring within 90days after initiation. Conclusion Thiazide-induced AEs are common in older adults. Greater attention should be paid to potential complications in prescribing thiazides to older adults, including closer laboratory monitoring before and after initiation of thiazides. C1 [Makam, Anil N.] Univ Texas SW Med Ctr Dallas, Div Gen Internal Med, Dallas, TX 75390 USA. [Boscardin, W. John; Mao, Yinghui; Steinman, Michael A.] Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, Div Geriatr, San Francisco, CA USA. [Boscardin, W. John] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. RP Makam, AN (reprint author), 5323 Harry Hines Blvd,Mail Code 9169, Dallas, TX 75390 USA. EM anil.makam@utsouthwestern.edu OI Makam, Anil/0000-0001-7072-9946 FU National Institute on Aging (NIA) [K23-AG030999, RC1-AG036377]; federal training grant from the National Research Service Award [T32HP19025-07-00] FX Conflict of Interest: This study was supported by Grants K23-AG030999 and RC1-AG036377 from the National Institute on Aging (NIA). Dr. Makam's work on this project was completed while he was a primary care research fellow at the University of California at San Francisco, funded by a federal training grant from the National Research Service Award (T32HP19025-07-00). NR 36 TC 7 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD JUN PY 2014 VL 62 IS 6 BP 1039 EP 1045 DI 10.1111/jgs.12839 PG 7 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA AJ4EJ UT WOS:000337624300005 PM 24823661 ER PT J AU Weiner, DK Morone, NE Spallek, H Karp, JF Schneider, M Washburn, C Dziabiak, MP Hennon, JG Elnicki, DM AF Weiner, Debra K. Morone, Natalia E. Spallek, Heiko Karp, Jordan F. Schneider, Michael Washburn, Carol Dziabiak, Michael P. Hennon, John G. Elnicki, D. Michael CA Univ Pittsburgh Ctr Excellence Pai TI E-Learning Module on Chronic Low Back Pain in Older Adults: Evidence of Effect on Medical Student Objective Structured Clinical Examination Performance SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE medical student education; older adults; low back pain; objective structured clinical examination ID EDUCATION; CARE; COMPETENCE; OUTCOMES AB The Institute of Medicine has highlighted the urgent need to close undergraduate and graduate educational gaps in treating pain. Chronic low back pain (CLBP) is one of the most common pain conditions, and older adults are particularly vulnerable to potential morbidities associated with misinformed treatment. An e-learning case-based interactive module was developed at the University of Pittsburgh Center of Excellence in Pain Education, one of 12 National Institutes of Health-designated centers, to teach students important principles for evaluating and managing CLBP in older adults. A team of six experts in education, information technology, pain management, and geriatrics developed the module. Teaching focused on common errors, interactivity, and expert modeling and feedback. The module mimicked a patient encounter using a standardized patient (the older adult with CLBP) and a pain expert (the patient provider). Twenty-eight medical students were not exposed to the module (Group 1) and 27 were exposed (Group 2). Their clinical skills in evaluating CLBP were assessed using an objective structured clinical examination (OSCE). Mean scores were 62.0 +/- 8.6 for Group 1 and 79.5 +/- 10.4 for Group 2 (P<.001). Using an OSCE pass-fail cutoff score of 60%, 17 of 28 Group 1 students (60.7%) and 26 of 27 Group 2 students (96.3%) passed. The CLBP OSCE was one of 10 OSCE stations in which students were tested at the end of a Combined Ambulatory Medicine and Pediatrics Clerkship. There were no between-group differences in performance on eight of the other nine OSCE stations. This module significantly improved medical student clinical skills in evaluating CLBP. Additional research is needed to ascertain the effect of e-learning modules on more-advanced learners and on improving the care of older adults with CLBP. C1 [Weiner, Debra K.; Morone, Natalia E.; Hennon, John G.] Vet Affairs Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA USA. [Weiner, Debra K.] Univ Pittsburgh, Dept Med, Div Geriatr Med, Pittsburgh, PA USA. [Weiner, Debra K.; Karp, Jordan F.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA. [Weiner, Debra K.; Karp, Jordan F.] Univ Pittsburgh, Dept Anesthesiol, Pittsburgh, PA USA. [Weiner, Debra K.; Morone, Natalia E.; Karp, Jordan F.] Univ Pittsburgh, Clin & Translat Sci Inst, Pittsburgh, PA USA. [Morone, Natalia E.; Dziabiak, Michael P.; Elnicki, D. Michael] Univ Pittsburgh, Dept Med, Div Gen Internal Med, Pittsburgh, PA USA. [Spallek, Heiko] Univ Pittsburgh, Sch Dent Med, Dept Dent Publ Hlth, Pittsburgh, PA USA. [Schneider, Michael] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Pittsburgh, PA USA. [Washburn, Carol] Univ Pittsburgh, Ctr Instruct Dev & Distance Educ, Pittsburgh, PA USA. [Hennon, John G.] Univ Pittsburgh, Univ Ctr Social & Urban Res, Pittsburgh, PA USA. RP Weiner, DK (reprint author), Suite 500,3471 Fifth Ave, Pittsburgh, PA 15213 USA. EM dweiner@pitt.edu OI Spallek, Heiko/0000-0001-6865-4818; Schneider, MIchael/0000-0001-7190-3379 FU Altarum Institute; NIH Pain Consortium [HHSN271201100111U] FX Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any-other kind of personal conflicts with this paper. This work was supported by funding awarded to Centers of Excellence in Pain Education by the Altarum Institute, which received funding from the NIH Pain Consortium (HHSN271201100111U). Dr. Karp has received medication supplies from Pfizer and Reckitt Benckiser for investigator-initiated trials. The contents of this report do not necessarily represent the views of the Department of Veterans Affairs OF the U.S. government. NR 29 TC 1 Z9 1 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD JUN PY 2014 VL 62 IS 6 BP 1161 EP 1167 DI 10.1111/jgs.12871 PG 7 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA AJ4EJ UT WOS:000337624300023 PM 24833496 ER PT J AU Moody, SY Newsom, EM Covinsky, KE AF Moody, Sandra Y. Newsom, Edwina M. Covinsky, Kenneth E. TI Determinants of Perceived Emotional Recovery and Perceived Change in Health After a Disaster SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Letter ID HURRICANE KATRINA; STORM C1 [Moody, Sandra Y.; Covinsky, Kenneth E.] Univ Calif San Francisco, Dept Med, Div Geriatr, San Francisco, CA 94117 USA. [Moody, Sandra Y.; Covinsky, Kenneth E.] San Francisco VA Med Ctr, San Francisco, CA USA. [Moody, Sandra Y.] Kameda Med Ctr, Kamogawa, Japan. [Newsom, Edwina M.] Univ Calif San Francisco, Inst Hlth & Aging, San Francisco, CA USA. RP Moody, SY (reprint author), Univ Calif San Francisco, Dept Med, Div Geriatr, San Francisco, CA 94117 USA. FU NCATS NIH HHS [UL1 TR000004]; NCRR NIH HHS [UL1 RR024131]; NIA NIH HHS [5R01AG28621, R01 AG028621] NR 10 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD JUN PY 2014 VL 62 IS 6 BP 1189 EP 1191 DI 10.1111/jgs.12852 PG 3 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA AJ4EJ UT WOS:000337624300031 PM 24925556 ER PT J AU Stankovic, I Krismer, F Jesic, A Antonini, A Benke, T Brown, RG Burn, DJ Holton, JL Kaufmann, H Kostic, VS Ling, H Meissner, WG Poewe, W Semnic, M Seppi, K Takeda, A Weintraub, D Wenning, GK AF Stankovic, Iva Krismer, Florian Jesic, Aleksandar Antonini, Angelo Benke, Thomas Brown, Richard G. Burn, David J. Holton, Janice L. Kaufmann, Horacio Kostic, Vladimir S. Ling, Helen Meissner, Wassilios G. Poewe, Werner Semnic, Marija Seppi, Klaus Takeda, Atsushi Weintraub, Daniel Wenning, Gregor K. CA Movement Disorders Soc MSA MODIMSA TI Cognitive Impairment in Multiple System Atrophy: A Position Statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) Study Group SO MOVEMENT DISORDERS LA English DT Article DE cognition; multiple system atrophy; neuropsychology ID PROGRESSIVE SUPRANUCLEAR PALSY; VOXEL-BASED MORPHOMETRY; IDIOPATHIC PARKINSONS-DISEASE; BRAIN GLUCOSE-METABOLISM; CEREBELLAR TYPE; STRIATONIGRAL DEGENERATION; FRONTAL-LOBE; OLIVOPONTOCEREBELLAR ATROPHY; DEPRESSIVE SYMPTOMS; CLINICAL-PARAMETERS AB Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidencebased review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy. (C) 2014 International Parkinson and Movement Disorder Society C1 [Stankovic, Iva; Kostic, Vladimir S.] Univ Belgrade, Sch Med, Clin Ctr Serbia, Neurol Clin, Belgrade, Serbia. [Krismer, Florian; Benke, Thomas; Poewe, Werner; Seppi, Klaus; Wenning, Gregor K.] Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria. [Jesic, Aleksandar; Semnic, Marija] Univ Novi Sad, Neurol Clin, Clin Ctr Vojvodina, Sch Med Novi Sad, Novi Sad 21000, Serbia. [Antonini, Angelo] IRCCS, Fdn Osped San Camillo, Dept Parkinsons Dis, Venice, Italy. [Brown, Richard G.] Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England. [Burn, David J.] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. [Holton, Janice L.; Ling, Helen] UCL, Inst Neurol, Queen Sq Brain Bank Neurol Disorders, London, England. [Kaufmann, Horacio] NYU, Langone Med Ctr, Dysautonomia Ctr, New York, NY USA. [Meissner, Wassilios G.] Univ Bordeaux, Inst Malad Neurodegenerat, Bordeaux, France. [Takeda, Atsushi] Sendai Nishitaga Hosp, Natl Hosp Org, Dept Neurol, Sendai, Miyagi, Japan. [Weintraub, Daniel] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Weintraub, Daniel] Univ Penn, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Weintraub, Daniel] Philadelphia Vet Affairs Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA USA. RP Wenning, GK (reprint author), Med Univ Innsbruck, Dept Neurol, Anichstr 35, A-6020 Innsbruck, Austria. EM gregor.wenning@i-med.ac.at RI Ling, Helen/J-3751-2013; Brown, Richard/A-9599-2010; Meissner, Wassilios/C-7817-2015 OI Brown, Richard/0000-0001-9021-0172; Meissner, Wassilios/0000-0003-2172-7527; Kaufmann, Horacio/0000-0002-1851-9981 FU Austrian Science Fund (FWF) [F04404-B19]; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre; Dementia Biomedical Research Unit at South London, and Maudsley NHS Foundation Trust and King's College London; Reta Lila Weston Institute for Neurological Studies; Multiple System Atrophy Trust; National Institute for Health Research University College London Hospitals Biomedical Research Centre FX This study was supported by funds of the Austrian Science Fund (FWF): F04404-B19. Dr. Brown acknowledges support from the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre and Dementia Biomedical Research Unit at South London, and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the author and not necessarily those of the NHS, the NIHR or the Department of Health. Dr. Holton is supported by the Reta Lila Weston Institute for Neurological Studies and the Multiple System Atrophy Trust. Part of the study was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. NR 80 TC 31 Z9 31 U1 1 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-3185 EI 1531-8257 J9 MOVEMENT DISORD JI Mov. Disord. PD JUN PY 2014 VL 29 IS 7 BP 857 EP 867 DI 10.1002/mds.25880 PG 11 WC Clinical Neurology SC Neurosciences & Neurology GA AJ4TZ UT WOS:000337670600007 PM 24753321 ER PT J AU Achey, M Aldred, JL Aljehani, N Bloem, BR Biglan, KM Chan, P Cubo, E Dorsey, ER Goetz, CG Guttman, M Hassan, A Khandhar, SM Mari, Z Spindler, M Tanner, CM van den Haak, P Walker, R Wilkinson, JR AF Achey, Meredith Aldred, Jason L. Aljehani, Noha Bloem, Bastiaan R. Biglan, Kevin M. Chan, Piu Cubo, Esther Dorsey, E. Ray Goetz, Christopher G. Guttman, Mark Hassan, Anhar Khandhar, Suketu M. Mari, Zoltan Spindler, Meredith Tanner, Caroline M. van den Haak, Pieter Walker, Richard Wilkinson, Jayne R. CA Int Parkinson Movement Disorder TI The Past, Present, and Future of Telemedicine for Parkinson's Disease SO MOVEMENT DISORDERS LA English DT Article DE telemedicine; Parkinson's disease ID NURSING-HOME RESIDENTS; RANDOMIZED CONTROLLED-TRIAL; SEDENTARY PATIENTS; PHYSICAL-ACTIVITY; CLINICAL-TRIALS; UNITED-STATES; HEALTH-CARE; PREVALENCE; HISTORY; PEOPLE AB Travel distance, growing disability, and uneven distribution of doctors limit access to care for most Parkinson's disease (PD) patients worldwide. Telemedicine, the use of telecommunications technology to deliver care at a distance, can help overcome these barriers. In this report, we describe the past, present, and likely future applications of telemedicine to PD. Historically, telemedicine has relied on expensive equipment to connect single patients to a specialist in pilot programs in wealthy nations. As the cost of video conferencing has plummeted, these efforts have expanded in scale and scope, now reaching larger parts of the world and extending the focus from care to training of remote providers. Policy, especially limited reimbursement, currently hinders the growth and adoption of these new care models. As these policies change and technology advances and spreads, the following will likely develop: integrated care networks that connect patients to a wide range of providers; education programs that support patients and health care providers; and new research applications that include remote monitoring and remote visits. Together, these developments will enable more individuals with PD to connect to care, increase access to expertise for patients and providers, and allow more-extensive, less-expensive participation in research. (C) 2014 International Parkinson and Movement Disorder Society C1 [Achey, Meredith; Dorsey, E. Ray] Univ Rochester, Med Ctr, Ctr Human Expt Therapeut, Rochester, NY 14642 USA. [Aldred, Jason L.] Northwest Neurol PLLC, Spokane, WA USA. [Aljehani, Noha; Mari, Zoltan] Johns Hopkins Med, Dept Neurol, Baltimore, MD USA. [Bloem, Bastiaan R.; van den Haak, Pieter] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol, Nijmegen, Netherlands. [Biglan, Kevin M.; Dorsey, E. Ray] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA. [Chan, Piu] Capital Med Univ, Dept Neurol & Neurobiol, Xuanwu Hosp,Beijing Inst Brain Disorders, Beijing Key Lab Parkinsons Dis,Parkinsons Dis Ctr, Beijing, Peoples R China. [Cubo, Esther] Univ Hosp, Dept Neurol, Burgos, Spain. [Goetz, Christopher G.] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Guttman, Mark] Univ Toronto, Div Neurol, Ctr Movement Disorders, Markham, ON, Canada. [Hassan, Anhar] Mayo Clin, Dept Neurol, Rochester, MN USA. [Khandhar, Suketu M.] Kaiser Permanente, Movement Disorders Program, Raleigh, NC USA. [Spindler, Meredith; Wilkinson, Jayne R.] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA. [Tanner, Caroline M.] Univ Calif San Francisco, Parkinsons Dis Res Educ & Clin Ctr, San Francisco Vet Affairs Med Ctr, San Francisco, CA 94143 USA. [Tanner, Caroline M.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Walker, Richard] North Tyneside Gen Hosp, Dept Med, North Shields, Tyne & Wear, England. [Wilkinson, Jayne R.] Dept Vet Affairs, Dept Neurol, Philadelphia, PA USA. RP Dorsey, ER (reprint author), Univ Rochester, Med Ctr, Ctr Human Expt Therapeut, 265 Crittenden Blvd,CU 420694, Rochester, NY 14642 USA. EM ray.dorsey@chet.rochester.edu RI Bloem, B.R./H-8013-2014 FU Davis Phinney Foundation; Great Lakes NeuroTechnologies; Michael J. Fox Foundation; Patient-Centered Outcomes Research Institute FX Dr. Biglan has telemedicine research-related grants with the Davis Phinney Foundation, Great Lakes NeuroTechnologies, Michael J. Fox Foundation, and the Patient-Centered Outcomes Research Institute and has filed a patent related to telemedicine and neurology. Dr. Dorsey has telemedicine research-related grants with the Davis Phinney Foundation, Great Lakes NeuroTechnologies, Michael J. Fox Foundation, and the Patient-Centered Outcomes Research Institute, is a member of the medical advisory board for, and has stock options in, Grand Rounds (an online second opinion service), is an unpaid advisor to SBR Health and Vidyo, and has filed a patent related to telemedicine and neurology. Dr. Goetz is an officer of the International Parkinson and Movement Disorder Society (MDS) that supports this program. Dr. Tanner is a coinvestigator on telemedicine research-related grants with the Davis Phinney Foundation, the Patient-Centered Outcomes Research Institute, and the MDS. NR 89 TC 22 Z9 22 U1 3 U2 24 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-3185 EI 1531-8257 J9 MOVEMENT DISORD JI Mov. Disord. PD JUN PY 2014 VL 29 IS 7 BP 871 EP 883 DI 10.1002/mds.25903 PG 13 WC Clinical Neurology SC Neurosciences & Neurology GA AJ4TZ UT WOS:000337670600011 PM 24838316 ER PT J AU Huerta, CI Sarkar, PR Duong, TQ Laird, AR Fox, PT AF Huerta, Claudia I. Sarkar, Pooja R. Duong, Timothy Q. Laird, Angela R. Fox, Peter T. TI Neural Bases of Food Perception: Coordinate-Based Meta-Analyses of Neuroimaging Studies in Multiple Modalities SO OBESITY LA English DT Article ID ALE METAANALYSIS; FUNCTIONAL MRI; BRAIN; ACTIVATION; ADDICTION; CALORIE; OBESITY; INSULA; CUES AB Objective: The purpose of this study was to compare the results of the three food-cue paradigms most commonly used for functional neuroimaging studies to determine: i) commonalities and differences in the neural response patterns by paradigm and ii) the relative robustness and reliability of responses to each paradigm. Methods: Functional magnetic resonance imaging studies using standardized stereotactic coordinates to report brain responses to food cues were identified using online databases. Studies were grouped by food-cue modality as: i) tastes (8 studies); ii) odors (8 studies); and, iii) images (11 studies). Activation likelihood estimation was used to identify statistically reliable regional responses within each stimulation paradigm. Results: Brain response distributions were distinctly different for the three stimulation modalities, corresponding to known differences in location of the respective primary and associative cortices. Visual stimulation induced the most robust and extensive responses. The left anterior insula was the only brain region reliably responding to all three stimulus categories. Conclusions: These findings suggest visual food-cue paradigm as promising candidate for imaging studies addressing the neural substrate of therapeutic interventions. C1 [Huerta, Claudia I.; Sarkar, Pooja R.; Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA. [Huerta, Claudia I.; Sarkar, Pooja R.; Duong, Timothy Q.; Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Duong, Timothy Q.; Laird, Angela R.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. [Laird, Angela R.] Florida Int Univ, Dept Phys, Miami, FL 33199 USA. [Fox, Peter T.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Huerta, CI (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA. EM fox@uthscsa.edu RI Fox, Peter/B-4725-2010 OI Fox, Peter/0000-0002-0465-2028 FU [R01 MH074457] FX This study was funded by R01 MH074457 (PTF and ARL, PIs). NR 40 TC 10 Z9 10 U1 0 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD JUN PY 2014 VL 22 IS 6 BP 1439 EP 1446 DI 10.1002/oby.20659 PG 8 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA AJ3AM UT WOS:000337537000009 PM 24174404 ER PT J AU Huddle, TS Kertesz, SG Nash, RR AF Huddle, Thomas S. Kertesz, Stefan G. Nash, Ryan R. TI Health Care Institutions Should Not Exclude Smokers From Employment SO ACADEMIC MEDICINE LA English DT Article ID SMOKING; WORKPLACE AB Some health care institutions, including academic health centers, have adopted policies excluding smokers from employment. Claims advanced on behalf of these policies include financial savings from reduced health costs and absenteeism as well as advantages consonant with their message of healthy living. The authors suggest that the institutional savings from these policies are speculative and unproven. Also, in settings where large medical schools operate, it is likely to be the poor, including members of minority groups, who, under an employee smoker ban, will lose the opportunity to work for an employer that offers health insurance and other benefits. In response to the incentives created by such bans, some will quit smoking, but most will not. Thus, at the community level, employee smoker bans are more likely to be harmful than beneficial. Although private businesses may rightly choose not to hire smokers in the 19 states where such policies are legal, health care institutions, including academic health centers, should consider hiring choices in light of the values they profess. The traditional values of medicine include service to all persons in need, even when illness results from addiction or unsafe behavior. Secular academic communities require a shared dedication to discovery without requiring strict conformity of private behavior or belief. The authors conclude that for health care institutions, policies of hiring smokers and helping them to quit are both prudent and expressive of the norms of medical care, such as inclusion, compassion, and fellowship, that academic health professionals seek to honor. C1 [Huddle, Thomas S.; Kertesz, Stefan G.] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA. [Huddle, Thomas S.] Univ Alabama Birmingham, Birmingham VA Med Ctr, Birmingham, AL USA. [Kertesz, Stefan G.] Birmingham VA Med Ctr, Birmingham, AL USA. [Nash, Ryan R.] Ohio State Univ, Ctr Bioeth, Columbus, OH 43210 USA. RP Huddle, TS (reprint author), FOT 720,1530 3rd Ave S, Birmingham, AL 35294 USA. EM thuddle@uab.edu OI Kertesz, Stefan/0000-0001-6101-8421 NR 24 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1040-2446 EI 1938-808X J9 ACAD MED JI Acad. Med. PD JUN PY 2014 VL 89 IS 6 BP 843 EP 847 DI 10.1097/ACM.0000000000000247 PG 5 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA AI8NU UT WOS:000337176300012 PM 24871233 ER PT J AU Momplaisir, F Yehia, BR Harhay, MO Fetzer, B Brady, KA Long, JA AF Momplaisir, Florence Yehia, Baligh R. Harhay, Michael O. Fetzer, Bradley Brady, Kathleen A. Long, Judith A. TI HIV Testing Trends: Southeastern Pennsylvania, 2002-2010 SO AIDS PATIENT CARE AND STDS LA English DT Article ID FOR-DISEASE-CONTROL; EMERGENCY-DEPARTMENT; ANTIRETROVIRAL THERAPY; UNITED-STATES; CLINICAL GUIDELINES; PREVALENCE AREA; SEXUAL HISTORY; CARE; PREVENTION; PROGRAM AB There are limited data on HIV testing trends after 2006 when the Centers for Disease Control and Prevention (CDC) introduced opt-out HIV testing with the aims of identifying HIV-infected persons early and linking them to care. We used data from the Southeastern Pennsylvania Household Health Survey between 2002 and 2010 to evaluate HIV testing over time. 50,698 adult (>= 18 years) survey respondents were included. HIV testing increased after the CDC recommendations: 42.1% of survey respondents received testing at least once in 2002 versus 51.4% in 2010, p < 0.001. Testing trends increased among all demographic groups, but existing differences in testing before 2006 persisted after that year as follows: younger patients, racial/ethnic minorities, patients on Medicaid were all more likely to get tested than their counterparts. Blacks and patients seeking care in community health centers had the fastest rise in HIV testing. The probability of HIV testing in Blacks was 0.56 (95% CI 0.54-0.60) in 2002 and increased to 0.73 (0.70-0.76) by 2010. Patients seeking care in community health centers had a probability of HIV testing of 0.57 (0.47-0.66) in 2002, which increased to 0.69 (0.60-0.77) by 2010. In comparison, patients in private clinics had an HIV testing probability of 0.40 (0.360.43) in 2002 compared to 0.47 (0.40-0.54) in 2010. HIV testing is increasing, particularly among ethnic minorities and in community health centers. However, testing remains to be improved in that setting and across all clinic types. C1 [Momplaisir, Florence] Temple Univ Hosp & Med Sch, Infect Dis Sect, Philadelphia, PA 19140 USA. [Yehia, Baligh R.] Univ Penn, Div Infect Dis, Perelman Sch Med, Philadelphia, PA 19104 USA. [Harhay, Michael O.; Fetzer, Bradley; Long, Judith A.] Univ Penn, Div Gen Internal Med, Perelman Sch Med, Philadelphia, PA 19104 USA. [Brady, Kathleen A.] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Long, Judith A.] Philadelphia VA Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. RP Momplaisir, F (reprint author), Temple Univ Hosp & Med Sch, Suite 501,3401 North Broad St, Philadelphia, PA 19140 USA. EM Florence.Momplaisir@tuhs.temple.edu OI Harhay, Michael/0000-0002-0553-674X FU NIMH NIH HHS [K23 MH097647] NR 48 TC 4 Z9 4 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1087-2914 EI 1557-7449 J9 AIDS PATIENT CARE ST JI Aids Patient Care STDS PD JUN PY 2014 VL 28 IS 6 BP 303 EP 310 DI 10.1089/apc.2014.0044 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AI9CG UT WOS:000337224700005 PM 24742326 ER PT J AU Ndiaye, MA Nihal, M Wood, GS Ahmad, N AF Ndiaye, Mary A. Nihal, Minakshi Wood, Gary S. Ahmad, Nihal TI Skin, Reactive Oxygen Species, and Circadian Clocks SO ANTIOXIDANTS & REDOX SIGNALING LA English DT Review ID SLEEP-WAKE CYCLES; OXIDATIVE STRESS; VITAMIN-A; DNA-DAMAGE; SIGNAL-TRANSDUCTION; RETINOIC ACID; EPIDERMAL-KERATINOCYTES; MELATONINERGIC SYSTEMS; EPITHELIAL-CELLS; BARRIER FUNCTION AB Significance: Skin, a complex organ and the body's first line of defense against environmental insults, plays a critical role in maintaining homeostasis in an organism. This balance is maintained through a complex network of cellular machinery and signaling events, including those regulating oxidative stress and circadian rhythms. These regulatory mechanisms have developed integral systems to protect skin cells and to signal to the rest of the body in the event of internal and environmental stresses. Recent Advances: Interestingly, several signaling pathways and many bioactive molecules have been found to be involved and even important in the regulation of oxidative stress and circadian rhythms, especially in the skin. It is becoming increasingly evident that these two regulatory systems may, in fact, be interconnected in the regulation of homeostasis. Important examples of molecules that connect the two systems include serotonin, melatonin, vitamin D, and vitamin A. Critical Issues: Excessive reactive oxygen species and/or dysregulation of antioxidant system and circadian rhythms can cause critical errors in maintaining proper barrier function and skin health, as well as overall homeostasis. Unfortunately, the modern lifestyle seems to contribute to increasing alterations in redox balance and circadian rhythms, thereby posing a critical problem for normal functioning of the living system. Future Directions: Since the oxidative stress and circadian rhythm systems seem to have areas of overlap, future research needs to be focused on defining the interactions between these two important systems. This may be especially important in the skin where both systems play critical roles in protecting the whole body. C1 [Ndiaye, Mary A.; Nihal, Minakshi; Wood, Gary S.; Ahmad, Nihal] Univ Wisconsin, Dept Dermatol, Madison, WI 53706 USA. [Wood, Gary S.; Ahmad, Nihal] William S Middleton Mem Vet Adm Med Ctr, Madison, WI 53705 USA. RP Ahmad, N (reprint author), Univ Wisconsin, Dept Dermatol, Med Sci Ctr, Room 423 1300 Univ Ave, Madison, WI 53706 USA. EM nahmad@wisc.edu FU NIH [R01AR059130, R01CA176748]; VA Merit Review Award [1I01BX001008] FX This work was partly supported by funding to N.A. from the NIH (R01AR059130 and R01CA176748) and VA Merit Review Award (1I01BX001008). NR 123 TC 5 Z9 6 U1 4 U2 22 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1523-0864 EI 1557-7716 J9 ANTIOXID REDOX SIGN JI Antioxid. Redox Signal. PD JUN PY 2014 VL 20 IS 18 BP 2982 EP 2996 DI 10.1089/ars.2013.5645 PG 15 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA AI8LN UT WOS:000337167100008 PM 24111846 ER PT J AU Barron, DS Tandon, N Lancaster, JL Fox, PT AF Barron, Daniel S. Tandon, Nitin Lancaster, Jack L. Fox, Peter T. TI Thalamic structural connectivity in medial temporal lobe epilepsy SO EPILEPSIA LA English DT Article DE Hippocampal sclerosis; Magnetic resonance imaging; Diffusion-weighted imaging; Thalamic connectivity ID DEEP BRAIN-STIMULATION; SEGMENTATION; PULVINAR; SEIZURES; NUCLEUS AB The thalamus has been implicated in various stages of medial temporal lobe epilepsy (MTLE) seizure evolution. The relative density and functional significance (in epileptogenesis) of thalamic projections to MTL subregions, however, remains to be determined. This study used structural and diffusion magnetic resonance imaging (MRI) to evaluate thalamic connection density with distinct MTL subregions in terms of location and volume. Nineteen MTLE patients with unilateral hippocampal sclerosis (HS; 12 right; 10 female) were compared to 19 age-matched controls. Five regions of interest (ROIs) per hemisphere were created in native space: thalamus, amygdala, entorhinal cortex, hippocampus, and parahippocampus. Separate probabilistic tractography analyses were performed between the thalamus and each ipsilateral MTL subregion (four per hemisphere). Individual connectivity profiles and regional volumes were assessed. The medial pulvinar consistently showed the highest connection density with the hippocampus in healthy controls and in MTLE patients. Decreased thalamic connected volume was observed for thalamohippocampal pathways in patients with MTLE, and indicates pathway-specific deafferentation. Regional hippocampal and thalamic atrophy was also observed, indicating gray and white matter loss in the thalamohippocampal pathway. Consistent localization of dense medial pulvinar (PuM) connectivity with the hippocampus suggests chronic PuM stimulation could modulate the MTLE seizure network. Decreased thalamic connected volume is a promising biomarker for epileptogenesis that merits longitudinal validation. C1 [Barron, Daniel S.; Lancaster, Jack L.; Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Barron, Daniel S.] Yale Univ, Sch Med, New Haven, CT 06510 USA. [Tandon, Nitin] Univ Texas Hlth Sci Ctr Houston, Dept Neurosurg, Houston, TX 77030 USA. [Lancaster, Jack L.; Fox, Peter T.] Univ Texas Hlth Sci Ctr Houston, Dept Radiol, Houston, TX 77030 USA. [Fox, Peter T.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Fox, Peter T.] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China. [Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA. RP Barron, DS (reprint author), Yale Univ, Sch Med, 367 Cedar St, New Haven, CT 06510 USA. EM daniel.s.barron@yale.edu RI Fox, Peter/B-4725-2010 OI Fox, Peter/0000-0002-0465-2028 FU [1F31 NS083160-01]; [RO1 MH074457] FX The authors thank Jose E. Cavazos (UTHSC-SA, edits), Kristin S. Budde (UTHSC-SA, edits), Vatche G. Baboyan (UTHSC-H, data transfer), and the patients who participated in this study. The authors also thank the anonymous reviewers for their time and helpful directives. This study was funded by 1F31 NS083160-01 (D.S.B.) and RO1 MH074457 (P.T.F.). NR 16 TC 14 Z9 15 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0013-9580 EI 1528-1167 J9 EPILEPSIA JI Epilepsia PD JUN PY 2014 VL 55 IS 6 BP e50 EP e55 DI 10.1111/epi.12637 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA AJ4DE UT WOS:000337620200001 PM 24802969 ER PT J AU Deyo, RA Dworkin, SF Amtmann, D Andersson, G Borenstein, D Carragee, E Carrino, J Chou, R Cook, K DeLitto, A Goertz, C Khalsa, P Loeser, J Mackey, S Panagis, J Rainville, J Tosteson, T Turk, D Von Korff, M Weinertt, DK AF Deyo, Richard A. Dworkin, Samuel F. Amtmann, Dagmar Andersson, Gunnar Borenstein, David Carragee, Eugene Carrino, John Chou, Roger Cook, Karon DeLitto, Anthony Goertz, Christine Khalsa, Partap Loeser, John Mackey, Sean Panagis, James Rainville, James Tosteson, Tor Turk, Dennis Von Korff, Michael Weinertt, Debra K. TI Report of the NIH Task Force on Research Standards for Chronic Low Back Pain SO JOURNAL OF PAIN LA English DT Article DE Low back pain; chronic low back pain; research standards; minimum dataset; NIH Task Force ID CLINICAL-PRACTICE GUIDELINE; DEFINING CHRONIC PAIN; INFORMATION-SYSTEM PROMIS; FUNCTION ITEM BANK; QUALITY-OF-LIFE; PRIMARY-CARE; PROGNOSTIC APPROACH; SCREENING TOOL; START BACK; OUTCOME MEASURES AB Despite rapidly increasing intervention, functional disability due to chronic low back pain (cLBP) has increased in recent decades. We often cannot identify mechanisms to explain the major negative impact cLBP has on patients' lives. Such cLBP is often termed non-specific and may be due to multiple biologic and behavioral etiologies. Researchers use varied inclusion criteria, definitions, baseline assessments, and outcome measures, which impede comparisons and consensus. Therefore, NIH Pain Consortium charged a Research Task Force (RTF) to draft standards for research on cLBP. The resulting multidisciplinary panel recommended using 2 questions to define cLBP; cLBP by its impact (defined by pain intensity, pain interference, and physical function); use of a minimum dataset to describe research participants (drawing heavily on the PROMIS methodology); reporting "responder analyses" in addition to mean outcome scores; and suggestions for future research and dissemination. The Pain Consortium has approved the recommendations, which investigators should incorporate into NIH grant proposals. The RTF believes that these recommendations will advance the field, help to resolve controversies, and facilitate future research addressing the genomic, neurologic, and other mechanistic substrates of chronic low back pain. We expect that the RTF recommendations will become a dynamic document and undergo continual improvement. Perspective: A task force was convened by the NIH Pain Consortium with the goal of developing research standards for chronic low back pain. The results included recommendations for definitions, a minimum dataset, reporting outcomes, and future research. Greater consistency in reporting should facilitate comparisons among studies and the development of phenotypes. (C) 2014 by the American Pain Society. Published by Elsevier Inc. All rights reserved C1 [Deyo, Richard A.; Chou, Roger] Oregon Hlth & Sci Univ, Portland, OR 97239 USA. [Dworkin, Samuel F.; Amtmann, Dagmar; Loeser, John; Turk, Dennis] Univ Washington, Seattle, WA 98195 USA. [Andersson, Gunnar] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Borenstein, David] George Washington Univ, Washington, DC USA. [Carragee, Eugene; Mackey, Sean] Stanford Univ, Stanford, CA 94305 USA. [Carrino, John] Johns Hopkins Univ, Baltimore, MD USA. [Cook, Karon] Northwestern Univ, Evanston, IL USA. [DeLitto, Anthony; Weinertt, Debra K.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [DeLitto, Anthony; Weinertt, Debra K.] Univ Pittsburgh, Pittsburgh, PA USA. [Goertz, Christine] Palmer Coll Chiropract, Davenport, IA USA. [Khalsa, Partap] Natl Ctr Complementary & Alternat Med, Bethesda, MD USA. [Panagis, James] NIAMSD, Bethesda, MD 20892 USA. [Rainville, James] New England Baptist Hosp, Roxbury Crossing, MA USA. [Tosteson, Tor] Dartmouth Coll, Hanover, NH USA. [Von Korff, Michael] Grp Hlth Res Inst, Seattle, WA USA. RP Deyo, RA (reprint author), Oregon Hlth & Sci Univ, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. EM deyor@ohsu.edu FU National Center for Complementary and Alternative Medicine; National Institute for Arthritis, Musculoskeletal, and Skin Diseases FX This study was supported by the National Center for Complementary and Alternative Medicine and the National Institute for Arthritis, Musculoskeletal, and Skin Diseases. NR 127 TC 31 Z9 31 U1 9 U2 18 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD JUN PY 2014 VL 15 IS 6 BP 569 EP 585 DI 10.1016/j.jpain.2014.03.005 PG 17 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AJ0HM UT WOS:000337331400001 PM 24787228 ER PT J AU Sobel, JD Vartanian, SM Gasper, WJ Grenon, M Rapp, JH Hiramoto, JS Chuter, TA Reilly, LM AF Sobel, Julia D. Vartanian, Shant M. Gasper, Warren J. Grenon, Marlene Rapp, Joseph H. Hiramoto, Jade S. Chuter, Timothy A. Reilly, Linda M. TI Factors Associated With Spinal Cord Ischemia After Multibranched Endovascular Thoracoabdominal Aneurysm Repair SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery CY JUN 05-07, 2014 CL Boston, MA SP Soc Vasc Surg C1 [Sobel, Julia D.; Vartanian, Shant M.; Gasper, Warren J.; Hiramoto, Jade S.; Chuter, Timothy A.; Reilly, Linda M.] Univ Calif San Francisco, Div Vasc & Endovasc Surg, San Francisco, CA 94143 USA. [Grenon, Marlene; Rapp, Joseph H.] San Francisco VA Med Ctr, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 SU S BP 22S EP 23S PG 2 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AI9ND UT WOS:000337258400046 ER PT J AU Ozaki, CK Hamdan, AD Barshes, NR Wyers, MC Hevelone, ND Belkin, M Nguyen, LL AF Ozaki, C. K. Hamdan, Allen D. Barshes, Neal R. Wyers, Mark C. Hevelone, Nathanael D. Belkin, Michael Nguyen, Louis L. TI Prospective, Randomized, Multi-Institutional Clinical Trial of a Silver Alginate Dressing to Reduce Lower Extremity Vascular Surgery Wound Complications SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery CY JUN 05-07, 2014 CL Boston, MA SP Soc Vasc Surg C1 [Ozaki, C. K.; Hevelone, Nathanael D.; Belkin, Michael; Nguyen, Louis L.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Hamdan, Allen D.; Wyers, Mark C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Medidcal Sch, Boston, MA 02215 USA. [Barshes, Neal R.] Baylor Coll Med, Michael E Debakey Vet Affairs Med Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 SU S BP 31S EP 31S PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AI9ND UT WOS:000337258400063 ER PT J AU Azarbal, AF Harris, S Mitchell, E Liem, TK Landry, GJ Edwards, J McLafferty, R Moneta, GL AF Azarbal, Amir F. Harris, Sheena Mitchell, Erica Liem, Timothy K. Landry, Gregory J. Edwards, James McLafferty, Robert Moneta, Gregory L. TI Nasal Methacillin-Resistant Staphylococcus aureus Colonization Is Associated With a Higher Postoperative Infection Rate After Major Lower Extremity Amputation SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery CY JUN 05-07, 2014 CL Boston, MA SP Soc Vasc Surg C1 [Azarbal, Amir F.; Edwards, James; McLafferty, Robert] Portland VA Med Ctr, Portland, OR USA. [Harris, Sheena; Mitchell, Erica; Liem, Timothy K.; Landry, Gregory J.; Moneta, Gregory L.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 SU S BP 72S EP 72S PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AI9ND UT WOS:000337258400150 ER PT J AU Landry, GJ Yarmosh, A Shukla, B Azarbal, AF Liem, TK Mitchell, E McLafferty, R Moneta, GL AF Landry, Gregory J. Yarmosh, Alla Shukla, Bhavesh Azarbal, Amir F. Liem, Timothy K. Mitchell, Erica McLafferty, Robert Moneta, Gregory L. TI Current Status of Symptomatic Nonatherosclerotic Mesenteric Vascular Disease SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery CY JUN 05-07, 2014 CL Boston, MA SP Soc Vasc Surg C1 [Landry, Gregory J.; Yarmosh, Alla; Shukla, Bhavesh; Liem, Timothy K.; Mitchell, Erica; Moneta, Gregory L.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Azarbal, Amir F.; McLafferty, Robert] Portland VA Med Ctr, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 SU S BP 105S EP 105S PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AI9ND UT WOS:000337258400219 ER PT J AU Kaatz, A Carnes, M AF Kaatz, Anna Carnes, Molly TI Stuck in the Out-Group: Jennifer Can't Grow Up, Jane's Invisible, and Janet's Over the Hill SO JOURNAL OF WOMENS HEALTH LA English DT Editorial Material ID WOMEN; STEREOTYPES; SPECIALTY; MEDICINE; CULTURE; FEMALE; SCHOOL; SEX AB Fifty years after Title IX, women remain sparsely represented in high ranks and leadership in academic medicine. Although men and women enter the career pipeline at similar rates, academic medicine does not equivalently advance them. Currently, women account for 32% of associate professors, 20% of full professors, 14% of department chairs, and 11% of deans at U. S. medical schools-far from the near sex parity seen in medical students since the 1990s. Over 30 years of research confirms that gender stereotypes can operate to disadvantage women in review processes and consequently bar their advancement in domains like science and medicine. The authors present three vignettes to illustrate how gender stereotypes can also operate to disadvantage women in social interactions by positioning them in the "out-group" for many career-advancing opportunities. The authors argue that policies alone will not achieve gender equity in the academic medicine workforce. Addressing stereotype-based gender bias is critical for the future of academic medicine. Interventions that treat gender bias as a remediable habit show promise in promoting gender equity and transforming institutional culture to achieve the full participation of women at all career stages. A critical step is to recognize when gender stereotyped assumptions are influencing judgments and decision making in ourselves and others, challenge them as unjust, and deliberately practice replacing them with accurate and objective data. C1 [Kaatz, Anna; Carnes, Molly] Univ Wisconsin, Ctr Womens Hlth Res, Madison, WI 53715 USA. [Carnes, Molly] Univ Wisconsin, Dept Med, Madison, WI 53715 USA. [Carnes, Molly] Univ Wisconsin, Dept Psychiat, Madison, WI 53715 USA. [Carnes, Molly] Univ Wisconsin, Dept Ind & Syst Engn, Madison, WI 53715 USA. [Carnes, Molly] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI USA. RP Carnes, M (reprint author), Univ Wisconsin, Ctr Womens Hlth Res, 700 Regent St,Suite 301, Madison, WI 53715 USA. EM mlcarnes@wisc.edu FU NIGMS NIH HHS [R01 GM111002, R25 GM083252] NR 27 TC 11 Z9 11 U1 3 U2 15 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD JUN PY 2014 VL 23 IS 6 BP 481 EP 484 DI 10.1089/jwh.2014.4766 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AI9BT UT WOS:000337222700001 PM 24844292 ER PT J AU Guo, FJ Moellering, DR Garvey, WT AF Guo, Fangjian Moellering, Douglas R. Garvey, W. Timothy TI Use of HbA1c for Diagnoses of Diabetes and Prediabetes: Comparison with Diagnoses Based on Fasting and 2-Hr Glucose Values and Effects of Gender, Race, and Age SO METABOLIC SYNDROME AND RELATED DISORDERS LA English DT Article ID LIFE-STYLE; PREVENTION PROGRAM; HEMOGLOBIN A(1C); TOLERANCE; ADULTS; A1C; PREVALENCE; TRIAL; CLASSIFICATION; MANAGEMENT AB Background: Glycated hemoglobin (HbA1c) has been advocated for the diagnosis of diabetes and prediabetes. Its performance has been commonly assessed in corroboration with elevated fasting plasma glucose (FPG), but not the combination of FPG and 2-hr glucose values. This study assesses receiver operating characteristics (ROC) curves of HbA1c pertaining to the diagnoses of prediabetes and diabetes by FPG and/or 2-hr glucose, and the effects of age, gender, and race. Methods: We assessed the utility of HbA1c for diagnosing diabetes and prediabetes among 5395 adults without known diabetes from the National Health and Nutrition Examination Survey (NHANES) 2005-2010. Results: Current cutoffs of HbA1c for diabetes (6.5%) or prediabetes (5.7%) exhibited low sensitivity (0.249 and 0.354, respectively) and high specificity in identifying patients diagnosed using both FPG and 2-hr glucose, resulting in large false-negative rates (75.1% and 64.9%). Misdiagnosis rates increased with age and in non-Hispanic whites and Mexican Americans. When HbA1c was combined with FPG for diagnoses, the false-negative rate remained high for diabetes (45.7%), but was reduced for prediabetes (9.2%). Conclusions: When assessed against diagnoses using both FPG and 2-hr glucose, HbA1c had low sensitivity and high specificity for identifying diabetes and prediabetes, which varied as a function of age and race. Regarding recently released American Diabetes Association (ADA) and joint European guidelines, it is important to consider that HbA1c values below 6.5% and 5.7% do not reliably exclude the presence of diabetes and prediabetes, respectively. Overall, the data argue for greater use of oral glucose tolerance tests (OGTTs) and both FPG and 2-hr glucose values for diagnosis of diabetes and prediabetes. C1 [Guo, Fangjian; Moellering, Douglas R.; Garvey, W. Timothy] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35233 USA. [Garvey, W. Timothy] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. RP Guo, FJ (reprint author), Univ Alabama Birmingham, Dept Nutr Sci, Webb 241,1675 Univ Blvd, Birmingham, AL 35233 USA. EM ilovedd@uab.edu; garveyt@uab.edu RI Guo, Fangjian/B-7705-2015 OI Guo, Fangjian/0000-0003-3729-2724 FU Merit Review program of the Department of Veterans Affairs, National Institutes of Health [DK-038765, DK-083562]; UAB Diabetes Research Center [P30-DK079626] FX We gratefully acknowledge our funding resources, including the Merit Review program of the Department of Veterans Affairs, National Institutes of Health (DK-038765 and DK-083562), and the UAB Diabetes Research Center (P30-DK079626). All data used in this study were collected by the National Center for Health Statistics Centers for Disease Control and Prevention. NR 35 TC 16 Z9 18 U1 3 U2 18 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-4196 EI 1557-8518 J9 METAB SYNDR RELAT D JI Metab. Syndr. Relat. Disord. PD JUN PY 2014 VL 12 IS 5 BP 258 EP 268 DI 10.1089/met.2013.0128 PG 11 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA AI9JV UT WOS:000337249800003 PM 24512556 ER PT J AU Genta, RM Sonnenberg, A AF Genta, Robert M. Sonnenberg, Amnon TI Big data in gastroenterology research SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY LA English DT Article ID INFLAMMATORY-BOWEL-DISEASE; PEPTIC-ULCER DISEASE; HELICOBACTER-PYLORI; HOSPITAL ADMISSION; BARRETTS-ESOPHAGUS; SURVEILLANCE; RISK; PREVALENCE; ENDOSCOPY; MORTALITY AB In epidemiological research, large datasets are essential to reliably capture small variations among comparative groups or detect new unsuspected associations. Although large databases of web-search information, social media, airline traffic and telephone records are already widely used to capture social trends, large databases in medical research are just emerging. With the universal use of electronic medical records underway, vast amounts of health-related information will become available for biomedical research. Accepting such new research tools-based on the analysis of large pre-existing datasets rather than hypothesis-driven, in-depth prospective study-will require a new mindset in clinical research, as data might be `messy' and only associations, but not causality, can be detected. In spite of such limitations, the utilization of these new resources for medical research harbours great potential for advancing knowledge about digestive diseases. C1 [Genta, Robert M.] Univ Texas SW Med Ctr Dallas, Med Ctr, Dallas, TX 75390 USA. [Genta, Robert M.] Mirace Life Sci, Miraca Life Sci Res Inst, Irving, TX 75039 USA. [Sonnenberg, Amnon] Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97239 USA. RP Genta, RM (reprint author), Univ Texas SW Med Ctr Dallas, Med Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM robert.genta@utsouthwestern.edu NR 39 TC 8 Z9 8 U1 1 U2 24 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1759-5045 EI 1759-5053 J9 NAT REV GASTRO HEPAT JI Nat. Rev. Gastroenterol. Hepatol. PD JUN PY 2014 VL 11 IS 6 DI 10.1038/nrgastro.2014.18 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AI9DX UT WOS:000337230500009 PM 24594912 ER PT J AU Axon, RN Penney, FT Kyle, TR Zapka, J Marsden, J Zhao, YM Mauldin, PD Moran, WP AF Axon, Robert N. Penney, Fletcher T. Kyle, Thomas R. Zapka, Jane Marsden, Justin Zhao, Yumin Mauldin, Patrick D. Moran, William P. TI A Hospital Discharge Summary Quality Improvement Program Featuring Individual and Team-based Feedback and Academic Detailing SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE Care transitions; Hospital discharge; Discharge summary; Quality improvement ID PRIMARY-CARE PHYSICIANS; INTERNAL-MEDICINE; VULNERABLE ELDERS; AFTER-DISCHARGE; RE-AIM; COMMUNICATION; PERFORMANCE AB Background: Discharge summaries are an important component of hospital care transitions typically completed by interns in teaching hospitals. However, these documents are often not completed in a timely fashion or do not include pertinent details of hospitalization. This report outlines the development and impact of a curriculum intervention to improve the quality of discharge summaries by interns and residents in Internal Medicine. A previous study demonstrated that a discharge summary curriculum featuring individualized feedback was associated with improved summary quality, but few subsequent studies have described implementation of similar curricula. No information exists on the utility of other strategies such as team-based feedback or academic detailing. Methods: Study participants were 96 Internal Medicine intern and resident physicians at an academic medical center-based training program. A comprehensive evidence-based discharge summary quality improvement program was developed and implemented that featured a discharge summary template to facilitate summary preparation, individual feedback, team-based feedback, academic detailing and an objective discharge summary evaluation instrument. Results: The discharge summary evaluation instrument had moderate interrater reliability (kappa = 0.72). Discharge summary scores improved from mean score of 70% to 82% (P = 0.05). Interns and residents participating in this program also reported increased confidence in producing and critiquing summaries. Conclusions: A comprehensive discharge summary curriculum can be feasibly implemented within the context of a residency program. Team-based feedback and academic detailing may serve to reinforce individual feedback and extend program reach. C1 [Axon, Robert N.] Ralph H Johnson Vet Affairs Med Ctr, Ctr Dis Prevent & Hlth Intervent Div Populat, Charleston, SC 29425 USA. [Axon, Robert N.; Penney, Fletcher T.; Kyle, Thomas R.; Marsden, Justin; Zhao, Yumin; Mauldin, Patrick D.; Moran, William P.] Med Univ S Carolina, Div Gen Internal Med & Geriatr, Charleston, SC 29425 USA. [Zapka, Jane] Med Univ S Carolina, Div Biostat & Epidemiol, Charleston, SC 29425 USA. [Mauldin, Patrick D.] South Carolina Coll Pharm, Charleston, SC USA. RP Axon, RN (reprint author), Ralph H Johnson Vet Affairs Med Ctr, Ctr Dis Prevent & Hlth Intervent Div Populat, 135 Rutledge Ave,MSC 591, Charleston, SC 29425 USA. EM axon@musc.edu FU Donald W. Reynolds Foundation; Medical University of South Carolina (MUSC) FX This study was supported by a grant from the Donald W. Reynolds Foundation entitled "Aging Q3: Quality Education, Quality Care, and Quality of Life" and matching funds provided by the Medical University of South Carolina (MUSC). NR 22 TC 7 Z9 7 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-9629 EI 1538-2990 J9 AM J MED SCI JI Am. J. Med. Sci. PD JUN PY 2014 VL 347 IS 6 BP 472 EP 477 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AI5IG UT WOS:000336898500009 PM 24845304 ER PT J AU Boyer-Guittaut, M Poillet, L Liang, QL Bole-Richard, E Ouyang, XS Benavides, GA Chakrama, FZ Fraichard, A Darley-Usmar, VM Despouy, G Jouvenot, M Delage-Mourroux, R Zhang, JH AF Boyer-Guittaut, Michael Poillet, Laura Liang, Qiuli Bole-Richard, Elodie Ouyang, Xiaosen Benavides, Gloria A. Chakrama, Fatima-Zahra Fraichard, Annick Darley-Usmar, Victor M. Despouy, Gilles Jouvenot, Michele Delage-Mourroux, Regis Zhang, Jianhua TI The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells SO AUTOPHAGY LA English DT Article DE autophagy; breast cancer; GABARAP; GABARAPL1; GEC1; LAMP1; LC3; lysosome; MDA-MB-436; mitochondria; mitophagy ID CENTRAL-NERVOUS-SYSTEM; OXIDATIVE STRESS; PARKINSONS-DISEASE; MESSENGER-RNAS; GLYCOGEN-METABOLISM; GABA(A) RECEPTOR; GENE-EXPRESSION; SMOKE EXPOSURE; PROTEIN; GEC1 AB GABARAPL1/GEC1 is an early estrogen-induced gene which encodes a protein highly conserved from C. elegans to humans. Overexpressed GABARAPL1 interacts with GABA A or kappa opioid receptors, associates with autophagic vesicles, and inhibits breast cancer cell proliferation. However, the function of endogenous GABARAPL1 has not been extensively studied. We hypothesized that GABARAPL1 is required for maintaining normal autophagic flux, and plays an important role in regulating cellular bioenergetics and metabolism. To test this hypothesis, we knocked down GABARAPL1 expression in the breast cancer MDA-MB-436 cell line by shRNA. Decreased expression of GABARAPL1 activated procancer responses of the MDA-MB-436 cells including increased proliferation, colony formation, and invasion. In addition, cells with decreased expression of GABARAPL1 exhibited attenuated autophagic flux and a decreased number of lysosomes. Moreover, decreased GABARAPL1 expression led to cellular bioenergetic changes including increased basal oxygen consumption rate, increased intracellular ATP, increased total glutathione, and an accumulation of damaged mitochondria. Taken together, our results demonstrate that GABARAPL1 plays an important role in cell proliferation, invasion, and autophagic flux, as well as in mitochondrial homeostasis and cellular metabolic programs. C1 [Boyer-Guittaut, Michael; Poillet, Laura; Bole-Richard, Elodie; Chakrama, Fatima-Zahra; Fraichard, Annick; Despouy, Gilles; Jouvenot, Michele; Delage-Mourroux, Regis] Univ Franche Comte, Lab Biochim, Estrogenes Express Genique & Pathol Syst Nerveux, F-25030 Besancon, France. [Boyer-Guittaut, Michael; Liang, Qiuli; Ouyang, Xiaosen; Benavides, Gloria A.; Darley-Usmar, Victor M.; Zhang, Jianhua] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Boyer-Guittaut, Michael; Liang, Qiuli; Ouyang, Xiaosen; Benavides, Gloria A.; Darley-Usmar, Victor M.; Zhang, Jianhua] Univ Alabama Birmingham, Ctr Free Rad Biol, Birmingham, AL USA. [Ouyang, Xiaosen; Zhang, Jianhua] Birmingham VA Med Ctr, Dept Vet Affairs, Birmingham, AL USA. RP Zhang, JH (reprint author), Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. EM michael.boyer-guittaut@univ-fcomte.fr; zhanja@uab.edu OI Zhang, Jianhua/0000-0002-2128-9574 FU Universite of Franche-Comte; Region de Franche-Comte; VA merit award; RDCC-APCC core (NIH P30 grant) [P30 AR48311]; [NIHR01-NS064090] FX Michael Boyer-Guittaut would like to thank his colleagues from the EA3922 team, Jacques Bahi, president of the Universite of Franche-Comte, Abderrazzak Kadmiri, director of UFR-ST of the Universite of Franche-Comte and the Universite of Franche-Comte for their support during this research project performed at the University of Alabama in Birmingham, AL, USA. Laura Poillet is supported by a fellowship of the Region de Franche-Comte. The authors acknowledge funding from the following sources: Dr Jianhua Zhang was supported by NIHR01-NS064090 and a VA merit award. Flow cytometry was supported by RDCC-APCC core (NIH P30 grant #P30 AR48311). The authors would like to thank Enid F Keyser (UAB Flow cytometry core, Birmingham, AL) for her technical help using the LSR-II Becton Dickinson flow cytometer. Authors are grateful to Jianhua Zhang's and Victor M Darley-Usmar's laboratory members for their technical help, advice, and critical reviewing of this manuscript. NR 64 TC 15 Z9 15 U1 1 U2 16 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8627 EI 1554-8635 J9 AUTOPHAGY JI Autophagy PD JUN PY 2014 VL 10 IS 6 BP 986 EP 1003 DI 10.4161/auto.28390 PG 18 WC Cell Biology SC Cell Biology GA AI6GT UT WOS:000336970800004 PM 24879149 ER PT J AU Ali, A Ku, JH Suhler, EB Choi, D Rosenbaum, JT AF Ali, Amro Ku, Jennifer H. Suhler, Eric B. Choi, Dongseok Rosenbaum, James T. TI The course of retinal vasculitis SO BRITISH JOURNAL OF OPHTHALMOLOGY LA English DT Article ID SYSTEMIC ASSOCIATIONS; MULTIPLE-SCLEROSIS; DISEASE; CORTICOSTEROIDS; PERIPHLEBITIS; EFFICACY AB Aims To determine if characteristics of retinal vasculitis correlate with ocular complications, or the response to different lines of treatment. Materials and methods We performed a computerised database analysis of 56 patients evaluated for uveitis at the Casey Eye Institute from September 1985 until May 2010. All patients had non-infectious retinal vasculitis and at least 1 year of follow-up. Results Although occlusive vasculitis was rare, retinal neovascularisation occurred much more commonly in the occlusive vasculitis subgroup than among the nonocclusive vasculitis subgroup (p<0.01). Epiretinal membrane (ERM) was found more commonly in the retinal vasculitis patients who presented with cotton wool spots and intraretinal haemorrhage compared to retinal vasculitis patients who presented with sheathing noted on clinical examination (p<0.01). Smoking was significantly related to vision loss. Age at presentation below 40 years correlated with therapy beyond oral corticosteroids Conclusions The heterogeneity of retinal vasculitis should be considered in providing prognostic information. Neovascularisation occurs more commonly in occlusive retinal vasculitis, and ERM is diagnosed more frequently in conjunction with cotton wool spots and intraretinal haemorrhage rather than just vascular sheathing. Cigarette use predicts visual loss and patients who are relatively young often receive treatment beyond oral corticosteroids. C1 [Ali, Amro; Ku, Jennifer H.; Suhler, Eric B.; Rosenbaum, James T.] Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR 97239 USA. [Ku, Jennifer H.; Suhler, Eric B.; Choi, Dongseok] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA. [Suhler, Eric B.] Portland VA Med Ctr, Portland, OR USA. [Rosenbaum, James T.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97239 USA. [Rosenbaum, James T.] Legacy Hlth Syst, Devers Eye Inst, Portland, OR USA. RP Ku, JH (reprint author), Oregon Hlth & Sci Univ, Dept Ophthalmol, Mailcode CEI,3375 Terwilliger blvd, Portland, OR 97239 USA. EM kuj@ohsu.edu FU Research to Prevent Blindness, through National Eye Institute; Stan and Madelle Rosenfeld Family Trust the William and Mary Bauman Foundation FX This work was supported by Research to Prevent Blindness, through a core grant from the National Eye Institute, and by funds from the Stan and Madelle Rosenfeld Family Trust the William and Mary Bauman Foundation. NR 26 TC 3 Z9 3 U1 0 U2 2 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0007-1161 EI 1468-2079 J9 BRIT J OPHTHALMOL JI Br. J. Ophthalmol. PD JUN PY 2014 VL 98 IS 6 BP 785 EP 789 DI 10.1136/bjophthalmol-2013-303443 PG 5 WC Ophthalmology SC Ophthalmology GA AI6JI UT WOS:000336979100017 PM 24511084 ER PT J AU Edrey, YH Salmon, AB AF Edrey, Yael H. Salmon, Adam B. TI Revisiting an age-old question regarding oxidative stress SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Review DE Aging; Life span; Longevity; Age-related disease; Mouse models; Free radicals ID METHIONINE-SULFOXIDE-REDUCTASE; MANGANESE SUPEROXIDE-DISMUTASE; REPLICATIVE LIFE-SPAN; TRANSGENIC MICE; MUSCLE ATROPHY; INSULIN-RESISTANCE; MITOCHONDRIAL-FUNCTION; ALZHEIMERS-DISEASE; KNOCKOUT MOUSE; IN-VIVO AB Significant advances in maintaining health;throughout life can be made through a clear understanding of the fundamental mechanisms that regulate aging. The Oxidative Stress Theory of Aging (OSTA) is probably the most well studied mechanistic theory of aging and suggests that the rate of aging is controlled by accumulation of oxidative damage. To directly test the OSTA, aging has been measured in several lines of mice with genetic alterations in the expression of enzymatic antioxidants. Under its strictest interpretation, these studies do not support the OSTA, as modulation of antioxidant expression does not generally affect mouse life span. However, the incidence of many age-related diseases and pathologies is altered in these models, suggesting that oxidative stress does significantly influence some aspects of the aging process. Further, oxidative stress may affect aging in disparate patterns among tissues or under various environmental conditions. In this review, we summarize the current literature regarding aging in antioxidant mutant mice and offer several interpretations of their support of the OSTA. Published by Elsevier Inc. C1 [Edrey, Yael H.; Salmon, Adam B.] Sam & Ann Barshop Inst Longev & Aging Studies & S, San Antonio, TX 78229 USA. [Salmon, Adam B.] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX 78229 USA. [Salmon, Adam B.] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA. RP Salmon, AB (reprint author), South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, 15355 Lambda Dr, San Antonio, TX 78245 USA. EM salmona@uthscsa.edu FU Geriatric Research, Education and Clinical Center of the South Texas Veterans Health Care Systems; San Antonio Nathan Shock Center [NIA 5P30 AG013319-19]; San Antonio Area Foundation FX The authors thank Arlan Richardson, Holly Van Remmen, and Yuji Ikeno for discussions that led to the compilation of this review and their yeoman's work over the past 15+ years in regard to testing the OSTA under the criteria above. This work was supported by the Geriatric Research, Education and Clinical Center of the South Texas Veterans Health Care Systems, a pilot grant from the San Antonio Nathan Shock Center (NIA 5P30 AG013319-19), and a Biomedical Research Grant from the San Antonio Area Foundation. NR 128 TC 24 Z9 24 U1 1 U2 30 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0891-5849 EI 1873-4596 J9 FREE RADICAL BIO MED JI Free Radic. Biol. Med. PD JUN PY 2014 VL 71 BP 368 EP 378 DI 10.1016/j.freeradbiomed.2014.03.038 PG 11 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA AI5FP UT WOS:000336891100033 PM 24704971 ER PT J AU Morris, DL Fernando, MMA Taylor, KE Chung, SA Nititham, J Alarcon-Riquelme, ME Barcelloss, LF Behrens, TW Cotsapas, C Gaffney, PM Graham, RR Pons-Estel, BA Gregersen, PK Harley, JB Hauser, SL Hom, G Langefeld, CD Noble, JA Rioux, JD Seldin, MF Vyse, TJ Criswell, LA AF Morris, D. L. Fernando, M. M. A. Taylor, K. E. Chung, S. A. Nititham, J. Alarcon-Riquelme, M. E. Barcelloss, L. F. Behrens, T. W. Cotsapas, C. Gaffney, P. M. Graham, R. R. Pons-Estel, B. A. Gregersen, P. K. Harley, J. B. Hauser, S. L. Hom, G. Langefeld, C. D. Noble, J. A. Rioux, J. D. Seldin, M. F. Vyse, T. J. Criswell, L. A. CA Syst Lupus Erythematosus Genet Con TI MHC associations with clinical and autoantibody manifestations in European SLE SO GENES AND IMMUNITY LA English DT Article DE Sub-phenotype analysis; MHC; meta-analysis; genetics; systemic lupus erythematosus; Europeans ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; RO SS-A; SUSCEPTIBILITY VARIANTS; RHEUMATOID-ARTHRITIS; LOCI; MODEL; DISEASES; REGION AB Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to nuclear components. Although genetic variation within the major histocompatibility complex (MHC) is associated with SLE, its role in the development of clinical manifestations and autoantibody production is not well defined. We conducted a meta-analysis- of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. Of the 11 American College of Rheumatology criteria and 7 autoantibody sub-phenotypes examined, anti-Ro/SSA and anti-La/SSB antibody subsets exhibited the highest number and most statistically significant associations. HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. We found evidence of associations independent of MHC class II variants in the anti-Ro subset alone. Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies. C1 [Morris, D. L.; Fernando, M. M. A.; Vyse, T. J.] Guys Hosp, Kings Coll London, Sch Med, Dept Med & Mol Genet, London SE1 9RT, England. [Taylor, K. E.; Chung, S. A.; Nititham, J.] Univ Calif San Francisco, Dept Med, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA USA. [Alarcon-Riquelme, M. E.] Pfizer Univ Granada Junta de Andalucia, Ctr Genom & Invest Oncol, GENYO, Dept Human DNA Variabil, Granada, Spain. [Alarcon-Riquelme, M. E.; Gaffney, P. M.] Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, Oklahoma City, OK 73104 USA. [Barcelloss, L. F.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Genet Epidemiol & Genom Lab, Berkeley, CA 94720 USA. [Behrens, T. W.; Graham, R. R.; Hom, G.] Genentech Inc, Immunol Biomarkers Grp, San Francisco, CA USA. [Cotsapas, C.] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06520 USA. [Pons-Estel, B. A.] Hosp Prov Rosario, Rheumatol Serv, Rosario, Argentina. [Gregersen, P. K.] North Shore LIJ Hlth Syst, Feinstein Inst Med Res, Robert S Boas Ctr Genom & Human Genet, Manhasset, NY USA. [Harley, J. B.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Harley, J. B.] US Dept Vet Affairs, Med Ctr, Cincinnati, OH USA. [Hauser, S. L.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Langefeld, C. D.] Wake Forest Univ Hlth Sci, Dept Biostat Sci, Wake Forest, NC USA. [Noble, J. A.] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA. [Rioux, J. D.] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada. [Rioux, J. D.] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada. [Seldin, M. F.] Univ Calif Davis, Davis, CA 95616 USA. RP Morris, DL (reprint author), Guys Hosp, Kings Coll London, Sch Med, Dept Med & Mol Genet, London SE1 9RT, England. EM david.l.morris@kcl.ac.uk RI Rioux, John/A-9599-2015 OI Rioux, John/0000-0001-7560-8326; Alarcon Riquelme, Marta Eugenia/0000-0002-7632-4154; Cotsapas, Chris/0000-0002-7772-5910 FU Swedish Research Council, lnstituto de Salud Carlos III [PI12/02558]; FEDER; EU; BIOLUPUS RNP; European Science Foundation; American College of Rheumatology Rheumatology Research Foundation Physician Scientist Development Award; National Institutes of Health; National Center for Advancing Translational Sciences through UCSF-CTSI [KL2TR000143]; Clinician Scientist Fellowship [18239]; DLM [17761/PI TJV]; Swedish Research Council and Instituto de Salud Carlos III [PS09/00129]; FEDER funds of the European Union; Consejeria de Salud de Andalucia [PI0012]; National Institutes of Allergy and Infectious Diseases [AI067152]; Wellcome Trust Case-Control Consortium [076113, 085475]; NIH [AR052300, AR02175, AR22804, AR42460, AI024717, AI083194, AR62277, AI082714, AI53747, AI31584, DE15223, RR20143, PR094002, AI62629, AR48940, AR19084, AR043274, AI063274, AI40076, AR052125, HG006828, AR048929, AR049084] FX We thank the original study participants and their families for their contributions to this research, along with clinical colleagues who facilitated data collection. We thank Alexander Dilthey for his advice during the HLA imputation. We also thank the investigators of IMAGEN (John D Rioux, Philippe Goyette, Timothy J Vyse, Lennart Hammarstrom, Michelle MA Fernando, Todd Green, Philip L De Jager, Sylvain Foisy, Joanne Wang, Paul IW de Bakker, Stephen Leslie, Gilean McVean, Leonid Padyukov, Lars Alfredsson, Vito Annese, David A Hafler, Qiang Pan-Hammarstrom, Ritva Matell, Stephen J Sawcer, Alastair D Compston, Bruce AC Cree, Daniel B Mirel, Mark J Daly, Tim W Behrens, Lars Klareskog, Peter K Gregersen, Jorge R Oksenberg and Stephen L Hauser).; A full list of the investigators who contributed to the generation of the Wellcome Trust Case-Control Consortium data is available from the WTCCC website (see Web Resources).; This study was founded by Swedish Research Council, lnstituto de Salud Carlos III (PI12/02558) partly financed by FEDER funds of the EU, and the BIOLUPUS RNP funded by the European Science Foundation to MEA-R; American College of Rheumatology Rheumatology Research Foundation Physician Scientist Development Award and National Institutes of Health, National Center for Advancing Translational Sciences through UCSF-CTSI Grant KL2TR000143 to SAC.; Arthritis Research UK funded a Clinician Scientist Fellowship for MMAF (ref 18239) and the Arthritis Research UK funded DLM under (ref 17761/PI TJV). MEA-R was funded by the Swedish Research Council and Instituto de Salud Carlos III grant number PS09/00129 cofinanced through FEDER funds of the European Union and the Consejeria de Salud de Andalucia PI0012.; The IMAGEN consortium was supported by Grant AI067152 from the National Institutes of Allergy and Infectious Diseases.; Funding for the Wellcome Trust Case-Control Consortium project was provided by the Wellcome Trust under award 076113 and 085475.; Cord blood samples were collected by V L Nimgaonkar's group at the University of Pittsburgh, as part of a multi-institutional collaborative research project with J Smoller, MD DSc and P Sklar, MD PhD. (Massachusetts General Hospital; grant MH 63420).; Support for the Illumina MHC Panel study was provided by the NIH (AR052300, AR02175, AR22804, AR62277, AR42460, AI024717, AI083194, AR62277, AI082714, AI53747, AI31584, DE15223, RR20143, PR094002, AI62629, AR48940, AR19084, AR043274, AI063274, AI40076, AR052125, HG006828, AR048929, and AR049084), research grants from the US Department of Veterans Affairs, US Department of Defense (PR094002), American College of Rheumatology, Alliance for Lupus Research, Rheuminations, the Lupus Foundation of Minnesota and the Mary Kirkland Center for Lupus Research. This study was performed in part in the General Clinical Research Center, Moffitt Hospital, University of California San Francisco, with funds provided by the National Center for Research Resources, 5 M01 RR-00079, US Public Health Service. NR 26 TC 18 Z9 19 U1 0 U2 6 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1466-4879 EI 1476-5470 J9 GENES IMMUN JI Genes Immun. PD JUN PY 2014 VL 15 IS 4 BP 210 EP 217 DI 10.1038/gene.2014.6 PG 8 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA AI5CT UT WOS:000336883700002 PM 24598797 ER PT J AU Kroenke, K AF Kroenke, Kurt TI Are the Harms of False-Positive Screening Test Results Minimal or Meaningful? SO JAMA INTERNAL MEDICINE LA English DT Editorial Material C1 [Kroenke, Kurt] US Dept Vet Affairs, Ctr Hlth Informat & Commun, Hlth Serv Res & Dev, Indianapolis, IN USA. [Kroenke, Kurt] Regenstrief Inst Inc, Indianapolis, IN 46202 USA. [Kroenke, Kurt] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA. RP Kroenke, K (reprint author), Regenstrief Inst Inc, 1050 Wishard Blvd,Fifth Floor, Indianapolis, IN 46202 USA. EM kkroenke@regenstrief.org NR 8 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JUN PY 2014 VL 174 IS 6 BP 961 EP 963 DI 10.1001/jamainternmed.2014.160 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AI4OA UT WOS:000336843500032 PM 24756378 ER PT J AU Wiener, RS Gould, MK Slatore, CG Fincke, BG Schwartz, LM Woloshin, S AF Wiener, Renda Soylemez Gould, Michael K. Slatore, Christopher G. Fincke, Benjamin G. Schwartz, Lisa M. Woloshin, Steven TI Resource Use and Guideline Concordance in Evaluation of Pulmonary Nodules for Cancer Too Much and Too Little Care SO JAMA INTERNAL MEDICINE LA English DT Article ID FLEISCHNER SOCIETY GUIDELINES; LUNG-CANCER; MANAGEMENT; RADIOLOGISTS; CT; COMPLICATIONS; STATEMENT; ADHERENCE; BIOPSY; FRANCE AB IMPORTANCE Pulmonary nodules are common, and more will be found with implementation of lung cancer screening. How potentially malignant pulmonary nodules are evaluated may affect patient outcomes, health care costs, and effectiveness of lung cancer screening programs. Guidelines for evaluating pulmonary nodules for cancer exist, but little is known about how nodules are evaluated in the usual care setting. OBJECTIVE To characterize nodule evaluation and concordance with guidelines. DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study was conducted including detailed review of medical records from pulmonary nodule detection through evaluation completion, cancer diagnosis, or study end (December 31, 2012). The participants included 300 adults with pulmonary nodules from 15 Veterans Affairs hospitals. MAIN OUTCOMES AND MEASURES Resources used for evaluation at any Veterans Affairs facility and guideline-concordant evaluation served as the main outcomes. RESULTS Twenty-seven of 300 patients (9.0%) with pulmonary nodules ultimately received a diagnosis of lung cancer: 1 of 57 (1.8%) with a nodule of 4 mm or less, 4 of 134 (3.0%) with a nodule of 5 to 8 mm, and 22 of 109 (20.2%) with a nodule larger than 8 mm. Nodule evaluation entailed 1044 imaging studies, 147 consultations, 76 biopsies, 13 resections, and 21 hospitalizations. Radiographic surveillance (n = 277) lasted a median of 13 months but ranged from less than 0.5 months to 8.5 years. Forty-six patients underwent invasive procedures (range per patient, 1-4): 41.3%(19 patients) did not have cancer and 17.4% (8) experienced complications, including 1 death. Notably, 15 of the 300 (5.0%) received no purposeful evaluation and had no obvious reason for deferral, seemingly "falling through the cracks." Among 197 patients with a nodule detected after release of the Fleischner Society guidelines, 44.7% received care inconsistent with guidelines (17.8% overevaluation, 26.9% underevaluation). In multivariable analyses, the strongest predictor of guideline-inconsistent care was inappropriate radiologist recommendations (overevaluation relative risk, 4.6 [95% CI, 2.3-9.2]; underevaluation, 4.3 [2.7-6.8]). Other systems factors associated with underevaluation included receiving care at more than 1 facility (2.0 [1.5-2.7]) and nodule detection during an inpatient or preoperative visit (1.6 [1.1-2.5]). CONCLUSIONS AND RELEVANCE Pulmonary nodule evaluation is often inconsistent with guidelines, including cases with no workup and others with prolonged surveillance or unneeded procedures that may cause harm. Systems to improve quality (eg, aligning radiologist recommendations with guidelines and facilitating communication across providers) are needed before lung cancer screening is widely implemented. C1 [Wiener, Renda Soylemez; Fincke, Benjamin G.] Edith Nourse Rogers Mem Vet Hosp, Ctr Healthcare Org & Implementat Res, Bedford, MA 01730 USA. [Wiener, Renda Soylemez] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA. [Wiener, Renda Soylemez; Schwartz, Lisa M.; Woloshin, Steven] Dartmouth Med Sch, Dartmouth Inst Hlth Policy & Clin Practice, Hanover, NH USA. [Gould, Michael K.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Slatore, Christopher G.] Portland VA Med Ctr, Hlth Serv Res & Dev, Portland, OR USA. [Slatore, Christopher G.] Oregon Hlth & Sci Univ, Div Pulm & Crit Care Med, Portland, OR 97201 USA. [Fincke, Benjamin G.] Boston Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Boston, MA USA. [Schwartz, Lisa M.; Woloshin, Steven] Dept Vet Affairs, Vet Affairs Outcomes Grp, White River Jct, VT USA. RP Wiener, RS (reprint author), Edith Nourse Rogers Mem Vet Hosp, Ctr Healthcare Org & Implementat Res, 200 Springs Rd,Bldg 70 Mail Code 152, Bedford, MA 01730 USA. EM rwiener@bu.edu OI Wiener, Renda/0000-0001-7712-2135; Slatore, Christopher/0000-0003-0958-8122 FU Veterans Affairs (VA) Health Services Research and Development (HSRD) [PPO 08-401]; White River Junction VA Medical Center; Edith Nourse Rogers Memorial Veterans Hospital; Portland VA Medical Center; National Cancer Institute [K07 CA138772]; VA HSR&D Career Development Award FX This study was supported by the Veterans Affairs (VA) Health Services Research and Development (HSR&D) (PPO 08-401) and with resources from the White River Junction VA Medical Center, Edith Nourse Rogers Memorial Veterans Hospital, and Portland VA Medical Center. Dr Wiener is also supported by career development award K07 CA138772 from the National Cancer Institute, and Dr Slatore is supported by a VA HSR&D Career Development Award. NR 37 TC 20 Z9 20 U1 1 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JUN PY 2014 VL 174 IS 6 DI 10.1001/jamainternmed.2014.561 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AI4OA UT WOS:000336843500017 PM 24710850 ER PT J AU van Deursen, VM Edwards, C Cotter, G Davison, BA Damman, K Teerlink, JR Metra, M Felker, GM Ponikowski, P Unemori, E Severin, T Voors, AA AF van Deursen, Vincent M. Edwards, Christopher Cotter, Gad Davison, Beth A. Damman, Kevin Teerlink, John R. Metra, Marco Felker, G. Michael Ponikowski, Piotr Unemori, Elaine Severin, Thomas Voors, Adriaan A. TI Liver Function, In-Hospital, and Post-Discharge Clinical Outcome in Patients With Acute Heart Failure-Results From the Relaxin for the Treatment of Patients With Acute Heart Failure Study SO JOURNAL OF CARDIAC FAILURE LA English DT Article DE Liver function; acute decompensated heart failure; prognosis ID FUNCTION TESTS; FUNCTION ABNORMALITIES; MORTALITY; PROGRAM AB Background: Elevated plasma concentrations of liver function tests are prevalent in patients with chronic heart failure (HF). Little is known about liver function in patients with acute HF. We aimed to assess the prevalence and prognostic value of serial measurements of liver function tests in patients admitted with acute decompensated HF. Methods: We investigated liver function tests from all 234 patients from the Relaxin for the Treatment of Patients With Acute Heart Failure study at baseline and during hospitalization. The end points were worsening HF through day 5, 60-day mortality or rehospitalization, and 180-day mortality. Results: Mean age was 70 +/- 10 years, 56% were male, and most patients were in New York Heart Association functional class III/IV (73%). Abnormal liver function tests were frequently found. for alanine transaminase (ALT; 12%), aspartate transaminase (AST; 21%), alkaline phosphatase (12%), and total bilirubin (19%), and serum albumin (25%) and total protein (9%) were decreased. In-hospital changes were very small. On a continuous scale, baseline ALT and AST were associated with 180-day mortality (hazard ratios [HRs; per doubling] 1.52 [P = .030] and 1.97 [P = .013], respectively) and worsening HF through day 5 (HRs [per doubling] 1.72 [P = .005] and 1.95 [P = .008], respectively). Albumin was associated with 180-day mortality (HR 0.86; P = .001) but not with worsening HF (HR 0.95; P = .248). Total protein was associated with only worsening HF (HR 0.91; P = .004). Conclusions: Abnormal liver function tests are often present in patients with acute HF and are associated with an increased risk for mortality, rehospitalization, and in-hospital worsening HF. C1 [van Deursen, Vincent M.; Damman, Kevin; Voors, Adriaan A.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. [Edwards, Christopher; Cotter, Gad; Davison, Beth A.] Momentum Res, Durham, NC USA. [Teerlink, John R.] Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, Cardiol Sect, San Francisco, CA 94143 USA. [Metra, Marco] Univ Brescia, Dept Expt & Appl Sci, Sect Cardiovasc Dis, Brescia, Italy. [Felker, G. Michael] Duke Univ, Duke Clin Res Inst, Durham, NC USA. [Ponikowski, Piotr] Med Univ, Dept Hlth Sci, Mil Hosp, Dept Cardiol, Wroclaw, Poland. [Unemori, Elaine] Corthera, San Mateo, CA USA. [Severin, Thomas] Novartis Pharmaceut, Basel, Switzerland. RP Voors, AA (reprint author), Univ Med Ctr Groningen, Dept Cardiol, Hanzepl 1, NL-9700 RB Groningen, Netherlands. EM a.a.voors@umcg.nl RI Ponikowski, Piotr/O-6454-2015 OI Ponikowski, Piotr/0000-0002-3391-7064; Davison, Beth/0000-0003-2374-6449; Metra, Marco/0000-0001-6691-8568 FU Corthera (a Novartis affiliate company); Amgen; Bayer; Corthera; Cardio3 Bioscience; Cytokinetics; Merck; Novartis; Takeda; Teva; Trevena; Abbott Vascular; Medpace; Otsuka; Roche Diagnostics; BG Medicine; Medtronic; St Jude; National Heart, Lung, and Blood Institute; Abbott; PDL Biopharma; Alere; Cardio3 Biosciences; Celladon; Ceva; European Commission; Dutch Heart Foundation; Servier; Torrent; Vifor FX The Pre-RELAX-AHF study is supported by Corthera (a Novartis affiliate company). Mr Edwards and Drs Cotter and Davison are employees of Momentum Research, which has provided consulting and trial management services to Novacardia, Merck, Corthera, Novartis, Nile Therapeutics, Bioheart, Cardio3 Biosciences, Amgen, Celadon, Targegen, Trevena, Sorbent Therapeutics, and the National Institutes of Health. Dr Teerlink has received research grants or consulting fees from Amgen, Bayer, Corthera, Cardio3 Bioscience, Cytokinetics, Merck, Novartis, Takeda, Teva, and Trevena. Dr Metra has received consulting income from Abbott Vascular, Bayer, Corthera, and Novartis and travel support and honoraria from Servier and Novartis. Dr Felker has received consulting income from Novartis, Medpace, Amgen, Otsuka, Trevena, Roche Diagnostics, Merck, BG Medicine, Medtronic, and St Jude and grant funding from Amgen, Otsuka, Roche Diagnostics, and the National Heart, Lung, and Blood Institute. Dr Ponikowski has been a consultant for Astellas, Bayer, EKR Therapeutics, Johnson and Johnson, The Medicines Company, Medtronic, Novartis, Otsuka, Palatin Technologies, PDL Biopharma, Pericor Therapeutics, Sigma Tau, Solvay Pharmaceuticals, and Trevena; has received honoraria from Alere, Beckman-Coulter, Biogenidec, Corthera, Ikaria, Nile Therapeutics, Momentum Research, and Overcome; has received research support from Abbott, Merck and PDL Biopharma; and has received travel support from My Life and equipment support from Sonosite. Dr Unemori is employed by the sponsor, Corthera. Dr Severin is an employee and shareholder of Novartis Pharma. Dr Voors has received consultancy fees and/or research grants from Alere, Bayer, Cardio3 Biosciences, Celladon, Ceva, the European Commission, the Dutch Heart Foundation, Novartis, Servier, Torrent, and Vifor. Dr van Deursen no relationships relevant to the contents of this paper to disclose. NR 18 TC 10 Z9 10 U1 0 U2 3 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI PHILADELPHIA PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA SN 1071-9164 EI 1532-8414 J9 J CARD FAIL JI J. Card. Fail. PD JUN PY 2014 VL 20 IS 6 BP 407 EP 413 DI 10.1016/j.cardfail.2014.03.003 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AI7LA UT WOS:000337070900005 PM 24642379 ER PT J AU Kasinath, BS AF Kasinath, Balakuntalam S. TI Hydrogen sulfide to the rescue in obstructive kidney injury SO KIDNEY INTERNATIONAL LA English DT Editorial Material ID CYSTATHIONINE-GAMMA-LYASE; RENAL ISCHEMIA/REPERFUSION; CELLS AB Hydrogen sulfide is a gasotransmitter with far-reaching effects on cell function. Studies show that, depending on the context, hydrogen sulfide can function as an ameliorative agent or as a mediator of kidney injury. C1 [Kasinath, Balakuntalam S.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. RP Kasinath, BS (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, MC7882,7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM kasinath@uthscsa.edu FU NIDDK NIH HHS [R01 DK077295] NR 12 TC 6 Z9 6 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0085-2538 EI 1523-1755 J9 KIDNEY INT JI Kidney Int. PD JUN PY 2014 VL 85 IS 6 BP 1255 EP 1258 DI 10.1038/ki.2013.529 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA AI4FG UT WOS:000336820500002 PM 24875544 ER PT J AU George, B Fan, QF Dlugos, CP Soofi, AA Zhang, JD Verma, R Park, TJ Wong, H Curran, T Nihalani, D Holzman, LB AF George, Britta Fan, Qingfeng Dlugos, Christopher P. Soofi, Abdulsalam A. Zhang, Jidong Verma, Rakesh Park, Tae-Ju Wong, Hetty Curran, Tom Nihalani, Deepak Holzman, Lawrence B. TI Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis SO KIDNEY INTERNATIONAL LA English DT Article DE cytoskeleton; nephrin; podocyte; signaling ID ACTIN CYTOSKELETON; SLIT DIAPHRAGM; INTERCELLULAR JUNCTION; TRANSGENIC MICE; NEPHRIN; EXPRESSION; PROTEINS; GENE; PROMOTES; FAMILY AB Activation of the slit diaphragm protein nephrin induces actin cytoskeletal remodeling, resulting in lamellipodia formation in podocytes in vitro in a phosphatidylinositol-3 kinase-, focal adhesion kinase-, Cas-, and Crk1/2-dependent fashion. In mice, podocyte-specific deletion of Crk1/2 prevents or attenuates foot process effacement in two models of podocyte injury. This suggests that cellular mechanisms governing lamellipodial protrusion in vitro are similar to those in vivo during foot process effacement. As Crk1/2-null mice developed and aged normally, we tested whether the Crk1/2 paralog, CrkL, functionally complements Crk1/2 in a podocyte-specific context. Podocyte-specific CrkL-null mice, like podocyte-specific Crk1/2-null mice, developed and aged normally but were protected from protamine sulfate-induced foot process effacement. Simultaneous podocyte-specific deletion of Crk1/2 and CrkL resulted in albuminuria detected by 6 weeks postpartum and associated with altered podocyte process architecture. Nephrin-induced lamellipodia formation in podocytes in vitro was CrkL-dependent. CrkL formed a hetero-oligomer with Crk2 and, like Crk2, was recruited to tyrosine phosphorylated nephrin. Thus, Crk1/2 and CrkL are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture. C1 [George, Britta; Fan, Qingfeng; Zhang, Jidong; Wong, Hetty; Nihalani, Deepak; Holzman, Lawrence B.] Univ Penn, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA. [George, Britta; Dlugos, Christopher P.] Univ Klinikum Munster, Med Klin & Poliklin D, Munster, Germany. [Soofi, Abdulsalam A.; Verma, Rakesh] Univ Michigan, Div Nephrol, Ann Arbor, MI 48109 USA. [Park, Tae-Ju; Curran, Tom] Childrens Hosp Philadelphia, Res Inst, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Holzman, Lawrence B.] Dept Vet Affairs Med Ctr, Philadelphia, PA 19104 USA. RP Holzman, LB (reprint author), Univ Penn, Renal Electrolyte & Hypertens Div, 405 Clin Res Bldg,415 Curie Blvd, Philadelphia, PA 19104 USA. EM lholzman@upenn.edu RI Curran, Tom/D-7515-2011 OI Park, Taeju/0000-0003-3897-3994 FU NIDDK [DK080751]; Department of Veterans Affairs; Deutsche Forschungsgemeinschaft [GE 2158/1-1, GE 2158/3-1]; Pennsylvania Department of Health Cure Formulary [4100047628] FX This work was supported by grants to LBH from the NIDDK (DK080751) and the Department of Veterans Affairs, and to BG from the Deutsche Forschungsgemeinschaft (GE 2158/1-1, GE 2158/3-1). This work was also supported by a Pennsylvania Department of Health Cure Formulary grant to TC (SAP #4100047628). NR 32 TC 7 Z9 7 U1 1 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0085-2538 EI 1523-1755 J9 KIDNEY INT JI Kidney Int. PD JUN PY 2014 VL 85 IS 6 BP 1382 EP 1394 DI 10.1038/ki.2013.556 PG 13 WC Urology & Nephrology SC Urology & Nephrology GA AI4FG UT WOS:000336820500020 PM 24499776 ER PT J AU Moonen, AJH Wijers, A Leentjens, AFG Christine, CW Factor, SA Juncos, J Lyness, JM Marsh, L Panisset, M Pfeiffer, R Rottenberg, D Ramos, CS Shulman, L Singer, C Slevin, J McDonald, W Auinger, P Richard, IH AF Moonen, A. J. H. Wijers, A. Leentjens, A. F. G. Christine, C. W. Factor, S. A. Juncos, J. Lyness, J. M. Marsh, L. Panisset, M. Pfeiffer, R. Rottenberg, D. Ramos, C. Serrano Shulman, L. Singer, C. Slevin, J. McDonald, W. Auinger, P. Richard, I. H. TI Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease SO PARKINSONISM & RELATED DISORDERS LA English DT Article DE Parkinson's disease; Depression; Clinical trials randomized controlled; Venlafaxine; Paroxetine ID DATABASE; PLACEBO AB Background: Antidepressants have appeared to be more effective than placebo treatment in treating depressive syndromes in patients with Parkinson's disease (PD). Objective: To identify factors that predict improvement in depressive symptoms during antidepressant treatment in depressed PD patients. Methods: A secondary analysis was performed on the dataset of the Randomized Placebo-controlled Study of Antidepressants in PD (SAD-PD), in which 76 patients received active treatment with either paroxetine or venlafaxine extended release (XR), and 39 patients received placebo treatment. Backward stepwise regression analyses were conducted with change in 24-item Hamilton Depression Rating Scale (HAMD-24) score between assessments at baseline and week 12 as the main outcome measure, and sex, age, baseline HAMD-24 score, Unified Parkinson's Disease Rating Scale section III (UPDRS-III) score, Mini-Mental State Examination (MMSE), and the Clinical Anxiety Scale (CAS) as independent variables. Results: In both the active treatment and placebo groups, higher baseline HAMD-24 score and lower UPDRS-III score were associated with greater reduction in HAMD-24 score. Higher anxiety scores predicted less response in the active treatment group. Higher MMSE scores predicted greater response only in the placebo-treated group. Sex and age were no predictors of response. Conclusions: Higher pre-treatment depression scores and lower pre-treatment anxiety scores are the two most important predictors for improvement during antidepressant treatment in depressed PD patients, which is in line with those found in treatment studies of depressed non-PD patients. Furthermore, our results indicate the requirement for different or more intensive treatment for depressed PD patients with more severe anxiety symptoms. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Moonen, A. J. H.; Wijers, A.; Leentjens, A. F. G.] Maastricht Univ, Dept Psychiat, NL-6200 MD Maastricht, Netherlands. [Christine, C. W.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Factor, S. A.; Juncos, J.] Emory Univ, Dept Neurol, Atlanta, GA USA. [McDonald, W.] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA. [Marsh, L.] Michael E DeBakey Vet Adm Med Ctr, Houston, TX USA. [Marsh, L.] Baylor Coll Med, Dept Psychiat, Houston, TX 77030 USA. [Marsh, L.] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA. [Panisset, M.] Univ Montreal, Dept Neurol, Montreal, PQ, Canada. [Pfeiffer, R.] Univ Tennessee, Dept Neurol, Hlth Sci Ctr, Memphis, TN USA. [Rottenberg, D.] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA. [Rottenberg, D.] Univ Minnesota, Dept Radiol, Minneapolis, MN 55455 USA. [Ramos, C. Serrano] Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA. [Shulman, L.] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA. [Singer, C.] Univ Miami, Dept Neurol, Leonard M Miller Sch Med, Miami, FL USA. [Slevin, J.] Univ Kentucky, Coll Med, Dept Neurol, Lexington, KY USA. [Lyness, J. M.; Auinger, P.; Richard, I. H.] Univ Rochester, Sch Med & Dent, Rochester, NY USA. RP Moonen, AJH (reprint author), Maastricht Univ, Dept Psychiat, POB 616, NL-6200 MD Maastricht, Netherlands. EM anja.moonen@maastrichtuniversity.nl FU National Institutes of Health/National Institute of Neurological Disorders and Stroke [R01 N5046487]; General Clinical Research Center at Johns Hopkins University School of Medicine (National Center for Research Resources/NIH) [M01-RR00052] FX This study was funded by National Institutes of Health/National Institute of Neurological Disorders and Stroke grant R01 N5046487 and the General Clinical Research Center at Johns Hopkins University School of Medicine (National Center for Research Resources/NIH M01-RR00052). Wyeth Pharmaceuticals provided venlafaxine extended release and matching placebo. Glaxo-Smith-Kline provided paroxetine. NR 10 TC 6 Z9 7 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8020 EI 1873-5126 J9 PARKINSONISM RELAT D JI Parkinsonism Relat. Disord. PD JUN PY 2014 VL 20 IS 6 BP 644 EP 646 DI 10.1016/j.parkreldis.2014.02.025 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA AI5AN UT WOS:000336877900016 PM 24679737 ER PT J AU Khodjaev, SD Teerlink, JR Malik, FI AF Khodjaev, Soidjon D. Teerlink, John R. Malik, Fady I. TI Novel drug mechanisms in development for heart failure SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY LA English DT Review DE BAY 94-8862; Heart failure; LCZ696; Omecamtiv mecarbil; Pharmacologic therapy; Serelaxin; TRV 027; Ularitide ID CARDIAC MYOSIN ACTIVATOR; DOUBLE-BLIND; MINERALOCORTICOID RECEPTOR; OMECAMTIV-MECARBIL; NATRIURETIC PEPTIDES; CONTROLLED-TRIAL; HORMONE RELAXIN; BAY 94-8862; TASK-FORCE; URODILATIN AB Heart failure therapy has seen many advances over the last 40 years and has rapidly expanded beyond diuretics and digoxin to include several new mechanisms of action and devices whose efficacy had been demonstrated in large clinical trials. The evidence for their use is thoroughly summarized and discussed in current heart failure treatment guidelines and is not the subject of this review. Despite these advances, the mortality and morbidity in heart failure patients is still substantial, and there remains a need to develop new heart failure therapies. Recognizing that advances in medical therapy are often driven by the introduction of drugs with novel mechanisms of action, here we provide an overview of investigative heart failure drugs with novel mechanisms of action that are the subject of ongoing clinical trials. C1 [Khodjaev, Soidjon D.; Teerlink, John R.] San Francisco VA Med Ctr, Cardiol Sect, San Francisco, CA 94121 USA. [Khodjaev, Soidjon D.; Teerlink, John R.; Malik, Fady I.] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Malik, Fady I.] Cytokinet Inc, Res & Early Dev, San Francisco, CA USA. RP Teerlink, JR (reprint author), San Francisco VA Med Ctr, Cardiol Sect, 111C,4150 Clement St, San Francisco, CA 94121 USA. EM john.teerlink@ucsf.edu NR 42 TC 0 Z9 0 U1 2 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0031-6768 EI 1432-2013 J9 PFLUG ARCH EUR J PHY JI Pflugers Arch. PD JUN PY 2014 VL 466 IS 6 BP 1219 EP 1225 DI 10.1007/s00424-014-1528-9 PG 7 WC Physiology SC Physiology GA AI4AO UT WOS:000336807700018 PM 24793049 ER PT J AU Yang, ZR Wang, C Zhou, QX An, JL Hildebrandt, E Aleksandrov, LA Kappes, JC DeLucas, LJ Riordan, JR Urbatsch, IL Hunt, JF Brouillette, CG AF Yang, Zhengrong Wang, Chi Zhou, Qingxian An, Jianli Hildebrandt, Ellen Aleksandrov, Luba A. Kappes, John C. DeLucas, Lawrence J. Riordan, John R. Urbatsch, Ina L. Hunt, John F. Brouillette, Christie G. TI Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains SO PROTEIN SCIENCE LA English DT Review DE CFTR; NBD1; DSC; CD; thermal unfolding; detergent interaction; membrane protein; extramembrane domain; soluble domain ID TRANSMEMBRANE CONDUCTANCE REGULATOR; NUCLEOTIDE-BINDING DOMAIN; DIFFERENTIAL SCANNING CALORIMETRY; CYSTIC-FIBROSIS MUTATION; CYTOCHROME-C-OXIDASE; FULL-LENGTH CFTR; DELTA-F508 MUTATION; SURFACTANT INTERACTIONS; ESCHERICHIA-COLI; EFFICIENT PURIFICATION AB Detergent interaction with extramembranous soluble domains (ESDs) is not commonly considered an important determinant of integral membrane protein (IMP) behavior during purification and crystallization, even though ESDs contribute to the stability of many IMPs. Here we demonstrate that some generally nondenaturing detergents critically destabilize a model ESD, the first nucleotide-binding domain (NBD1) from the human cystic fibrosis transmembrane conductance regulator (CFTR), a model IMP. Notably, the detergents show equivalent trends in their influence on the stability of isolated NBD1 and full-length CFTR. We used differential scanning calorimetry (DSC) and circular dichroism (CD) spectroscopy to monitor changes in NBD1 stability and secondary structure, respectively, during titration with a series of detergents. Their effective harshness in these assays mirrors that widely accepted for their interaction with IMPs, i.e., anionic>zwitterionic>nonionic. It is noteworthy that including lipids or nonionic detergents is shown to mitigate detergent harshness, as will limiting contact time. We infer three thermodynamic mechanisms from the observed thermal destabilization by monomer or micelle: (i) binding to the unfolded state with no change in the native structure (all detergent classes); (ii) native state binding that alters thermodynamic properties and perhaps conformation (nonionic detergents); and (iii) detergent binding that directly leads to denaturation of the native state (anionic and zwitterionic). These results demonstrate that the accepted model for the harshness of detergents applies to their interaction with an ESD. It is concluded that destabilization of extramembranous soluble domains by specific detergents will influence the stability of some IMPs during purification. C1 [Yang, Zhengrong; Brouillette, Christie G.] Univ Alabama Birmingham, Dept Chem, Birmingham, AL 35294 USA. [Yang, Zhengrong; Zhou, Qingxian; An, Jianli; DeLucas, Lawrence J.; Brouillette, Christie G.] Univ Alabama Birmingham, Struct Biol Ctr, Birmingham, AL USA. [Wang, Chi; Hunt, John F.] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA. [Hildebrandt, Ellen; Urbatsch, Ina L.] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA. [Aleksandrov, Luba A.; Riordan, John R.] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC USA. [Aleksandrov, Luba A.; Riordan, John R.] Univ N Carolina, Cyst Fibrosis Treatment & Res Ctr, Chapel Hill, NC USA. [Kappes, John C.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Kappes, John C.] Birmingham Vet Affairs Med Ctr, Res Serv, Birmingham, AL USA. [DeLucas, Lawrence J.] Univ Alabama Birmingham, Dept Optometry, Birmingham, AL USA. [Urbatsch, Ina L.] Texas Tech Univ, Hlth Sci Ctr, Ctr Membrane Prot Res, Lubbock, TX 79430 USA. RP Brouillette, CG (reprint author), 1025 18th St South,234 CBSE, Birmingham, AL 35294 USA. EM jfhunt@biology.columbia.edu; christie@uab.edu FU CFFT; NIH [R01 DK051619, R0 1DK051870, P01 HL110873]; Shared Facility Program of the UAB Comprehensive Cancer Center [316851] FX Grant sponsor: CFFT (to C. B., J.H., I. U., J.R., L. D., and J.K.). Grant sponsor: NIH R01 DK051619; R0 1DK051870; P01 HL110873 (to J.R.). Grant sponsor: Shared Facility Program of the UAB Comprehensive Cancer Center; Grant number: 316851. NR 102 TC 12 Z9 12 U1 1 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0961-8368 EI 1469-896X J9 PROTEIN SCI JI Protein Sci. PD JUN PY 2014 VL 23 IS 6 BP 769 EP 789 DI 10.1002/pro.2460 PG 21 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AI4NW UT WOS:000336843100010 PM 24652590 ER PT J AU Davis, LA Whitfield, E Cannon, GW Wolff, RK Johnson, DS Reimold, AM Kerr, GS Richards, JS Mikuls, TR Caplan, L AF Davis, Lisa A. Whitfield, Emily Cannon, Grant W. Wolff, Roger K. Johnson, Dannette S. Reimold, Andreas M. Kerr, Gail S. Richards, J. Steuart Mikuls, Ted R. Caplan, Liron TI Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis SO RHEUMATOLOGY LA English DT Article DE arthritis; rheumatoid; polymorphism; single nucleotide; cholesterol; HDL; LDL; triglycerides ID NF-KAPPA-B; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR RISK-FACTORS; C-REL; DISEASE SUSCEPTIBILITY; MYOCARDIAL-INFARCTION; VASCULAR-DISEASE; NUCLEAR-FACTOR; POLYMORPHISM; TRANSCRIPTION AB Objective. RA patients have an increased risk of cardiovascular (CV) disease, although the mechanisms are unclear. As RA and CV disease may be associated through lipid profiles, we examined whether single nucleotide polymorphisms (SNPs) associated with RA susceptibility were associated with low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride (TG) levels in RA subjects. Methods. Patients (n = 763) enrolled in the Veterans Affairs RA registry who were not on hydroxymethyl-glutaryl-CoA reductase inhibitor were genotyped for human leukocyte antigen shared epitope (HLA-DRB1-SE) and SNPs in the following genes: CTLA-4 (cytotoxic T-lymphocyte antigen 4), IL-10, PTPN22 (protein tyrosine phosphatase, non-receptor type 22), REL (c-Rel), STAT4 (signal transducer and activator of transcription protein), TNF-alpha and TRAF1 (TNF receptor-associated factor 1). Other covariates included patient characteristics (age, gender, race, smoking status, education, BMI, modified Charlson-Deyo comorbidity index), CV characteristics (hypertension, diabetes, alcohol abuse), pharmacologic exposures (MTX, anti-TNF, glucocorticoids) and RA severity/activity markers (RA disease duration, mean DAS, CRP, RF positivity, anti-CCP positivity). Multivariate linear regression was performed to determine the factors associated with LDL, HDL and TG levels. Results. The REL SNP rs9309331 homozygous minor allele was associated with higher LDL levels. Caucasian race and increasing BMI were associated with lower HDL. Factors associated with higher TG were diabetes, Caucasian race and higher BMI. Conclusion. The REL SNP rs9309331 was associated with LDL levels in our study. This association is a possible explanation of the increased risk of RA patients for CV disease and requires further inquiry. C1 [Davis, Lisa A.] Univ Colorado, Sch Med, Dept Med, Div Rheumatol,Denver Hlth Med Ctr, Denver, CO USA. [Whitfield, Emily; Caplan, Liron] Univ Colorado, Sch Med, Dept Med, Div Rheumatol,Denver Vet Affairs Med Ctr VAMC, Denver, CO USA. [Davis, Lisa A.; Caplan, Liron] Univ Colorado, Sch Med, Dept Med, Div Rheumatol, Denver, CO USA. [Whitfield, Emily] Denver VAMC, Dept Res, Div Care Coordinat, Denver, CO USA. [Cannon, Grant W.] George E Wahlen VAMC, Staff Acad Affiliat, Salt Lake City, UT USA. [Cannon, Grant W.] Univ Utah, Sch Med, Dept Med, Div Rheumatol, Salt Lake City, UT USA. [Wolff, Roger K.] Univ Utah, Sch Med, Dept Internal Med, Div Epidemiol, Salt Lake City, UT USA. [Johnson, Dannette S.] Jackson VAMC, Med Serv, Rheumatol Sect, Jackson, MS USA. [Johnson, Dannette S.] Univ Mississippi, Dept Internal Med, Div Rheumatol & Mol Immunol, Jackson, MS 39216 USA. [Reimold, Andreas M.] Dallas VAMC, Med Serv, Rheumatol Sect, Dallas, TX USA. [Reimold, Andreas M.] Univ Texas Dallas, SW Med Ctr, Dept Internal Med, Dallas, TX USA. [Kerr, Gail S.; Richards, J. Steuart] VAMC, Med Serv, Rheumatol Sect, Washington, DC USA. [Kerr, Gail S.; Richards, J. Steuart] Georgetown Univ, Dept Med, Div Rheumatol, Washington, DC USA. [Mikuls, Ted R.] Omaha VAMC, Med Serv, Rheumatol Sect, Omaha, NE USA. [Mikuls, Ted R.] Univ Nebraska Med Ctr, Nebraska Arthrit Outcomes Res Ctr, Omaha, NE USA. RP Davis, LA (reprint author), Denver Hlth & Hosp Author, 777 Bannock St,MC 4000, Denver, CO 80204 USA. EM lisa.davis@ucdenver.edu FU Veterans Affairs Health Services Research and Development Grant [SHP 08-172]; University of Colorado Denver, Division of Rheumatology; National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [T32 AR007534-24]; National Institutes of Health Loan Repayment Award; Rheumatology Research Foundation Rheumatology Scientist Development Award; Denver Health and Hospital Authority; University of Colorado; Colorado Clinical and Translational Science Institute; Veterans Affairs Health Services Research and Development Career Development Award [CDA 07-221] FX This work, including the genotyping, was supported by a Veterans Affairs Health Services Research and Development Grant (SHP 08-172) and the University of Colorado Denver, Division of Rheumatology. L.D. received support from the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32 AR007534-24), National Institutes of Health Loan Repayment Award, the Rheumatology Research Foundation Rheumatology Scientist Development Award, Denver Health and Hospital Authority, the University of Colorado and the Colorado Clinical and Translational Science Institute. L.C. received support from a Veterans Affairs Health Services Research and Development Career Development Award (CDA 07-221). The funding sources had no role in the design, collection, analysis, interpretation of data, writing of the report or decision to submit this article for publication. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or US government. All investigators participating in this research had access to all data. We declare that we (and our spouses, partners and children under 18 years of age) have no financial or personal relationships with other people or organizations that could inappropriately influence (bias) this work, including employment, consultancies, stock ownership, honoraria, paid expert testimony, patents or patent applications and travel grants, within 5 years of beginning the work submitted. NR 49 TC 6 Z9 6 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-0324 EI 1462-0332 J9 RHEUMATOLOGY JI RHEUMATOLOGY PD JUN PY 2014 VL 53 IS 6 BP 1014 EP 1021 DI 10.1093/rheumatology/ket472 PG 8 WC Rheumatology SC Rheumatology GA AI6KJ UT WOS:000336982600008 PM 24489016 ER PT J AU Kratz, M Marcovina, S Nelson, JE Yeh, MM Kowdley, KV Callahan, HS Song, XL Di, CZ Utzschneider, KM AF Kratz, Mario Marcovina, Santica Nelson, James E. Yeh, Matthew M. Kowdley, Kris V. Callahan, Holly S. Song, Xiaoling Di, Chongzhi Utzschneider, Kristina M. TI Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not beta-cell function in humans SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID TRANS-PALMITOLEIC ACID; ADIPOSE-TISSUE; PLASMA; VALIDATION; BIOMARKERS; RESISTANCE; ADULTS; RISK AB Background: Plasma phospholipid concentrations of trans-palmitoleic acid (trans-16: ln-7), a biomarker of dairy fat intake, are inversely associated with incident type 2 diabetes in 2 US cohorts. Objective: The objective was to investigate whether the intake of trans-16: ln-7 in particular, or dairy fat in general, is associated with glucose tolerance and key factors determining glucose tolerance. Design: A cross-sectional investigation was undertaken in 17 men and women with nonalcoholic fatty liver disease and 15 body mass index (BMI)- and age-matched controls. The concentrations of trans-16:1n 7 and 2 other biomarkers of dairy fat intake, 15:0 and 17:0, were measured in plasma phospholipids and free fatty acids (FFAs). Liver fat was estimated by computed tomography derived liver-spleen ratio. Intravenous-glucose-tolerance tests and oralglucose-tolerance test (OGTT) and hyperinsulinemic-euglycemic clamps were performed to assess beta-cell function and hepatic and systemic insulin sensitivity. Results: In multivariate analyses adjusted for age, sex, and BMI, phospholipid 17:0, phospholipid trans-16:1n-7, PIA 15:0, and FFA 17:0 were inversely associated with fasting plasma glucose, the area under the curve for glucose during an OGTT, and liver fat. Phospholipid trans-16:1n 7 was also positively associated with hepatic and systemic insulin sensitivity. None of the biomarkers were associated with beta-cell function. The associations between dairy fat intake and glucose tolerance were attenuated by adjusting for insulin sensitivity or liver fat, but strengthened by adjusting for beta-cell function. Conclusion: Although we cannot rule out reverse causation, these data support the hypothesis that dairy fat improves glucose tolerance, possibly through a mechanism involving improved hepatic and systemic insulin sensitivity and reduced liver fat. This trial was registered at clinicaltrials.gov as NCT01289639. C1 [Kratz, Mario; Song, Xiaoling] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, Seattle, WA 98109 USA. [Di, Chongzhi] Biostat Program, Seattle, WA 98109 USA. [Kratz, Mario; Utzschneider, Kristina M.] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USA. [Kratz, Mario] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Yeh, Matthew M.] Univ Washington, Dept Pathol, Seattle, WA 98195 USA. [Marcovina, Santica] Univ Washington, Northwest Lipid Res Labs, Seattle, WA 98195 USA. [Nelson, James E.; Kowdley, Kris V.] Virginia Mason Med Ctr, Benaroya Res Inst, Seattle, WA 98101 USA. [Callahan, Holly S.] Univ Washington, Inst Translat Hlth Sci, Seattle, WA 98195 USA. [Utzschneider, Kristina M.] VA Puget Sound Hlth Care Syst, Dept Med, Div Endocrinol, Seattle, WA USA. RP Kratz, M (reprint author), Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Mail Stop M4-B402,1100 Fairview Ave North, Seattle, WA 98109 USA. EM mkratz@fhcrc.org FU US Department of Veterans Affairs, Office of Research and Development Medical Research Service; NIH [UL1RR025014, P30DK017047, P30DK035816, DK020579, RR000954, DK056341, T32DK007247, U01DK061728, K24DK002957, R21ES022332] FX Supported by the US Department of Veterans Affairs, Office of Research and Development Medical Research Service, and NIH grant nos. UL1RR025014, P30DK017047, P30DK035816, DK020579, RR000954, DK056341, T32DK007247, U01DK061728, K24DK002957, and R21ES022332. NR 20 TC 19 Z9 19 U1 1 U2 15 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD JUN PY 2014 VL 99 IS 6 BP 1385 EP 1396 DI 10.3945/ajcn.113.075457 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AH9NW UT WOS:000336470100011 PM 24740208 ER PT J AU Turner, AP Williams, RM Norvell, DC Henderson, AW Hakimi, KN Blake, DJ Czerniecki, JM AF Turner, Aaron P. Williams, Rhonda M. Norvell, Daniel C. Henderson, Alison W. Hakimi, Kevin N. Blake, Donna Jo Czerniecki, Joseph M. TI Prevalence and 1-Year Course of Alcohol Misuse and Smoking in Persons with Lower Extremity Amputation as a Result of Peripheral Arterial Disease SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION LA English DT Article DE Smoking; Alcohol Misuse; Amputation; Prevalence; Social Support ID SPINAL-CORD-INJURY; DISORDERS IDENTIFICATION TEST; TYPE-2 DIABETES-MELLITUS; LOWER-LIMB AMPUTATION; 6.5-YEAR FOLLOW-UP; RISK-FACTORS; SOCIAL SUPPORT; MULTIPLE-SCLEROSIS; CIGARETTE-SMOKING; UNITED-STATES AB Objective The aim of this study was to describe prevalence of alcohol misuse and smoking among individuals with amputations as a result of peripheral arterial disease before surgery and 12 mos after surgery, changes in these behaviors over time, and factors associated with change. Design This is a prospective cohort study of 75 veterans experiencing their first major unilateral amputation. Measures included demographic and general health information, Alcohol Use Disorders Identification Test, smoking behaviors, and social support. Results Sixteen percent of the participants reported engaging in alcohol misuse at presurgical baseline; and 13% at 12 mos after amputation. Thirty-seven percent of the participants were categorized as smokers at baseline; this number dropped to 29% at 12 mos after amputation. Among those who decreased drinking and quit smoking, there was a trend indicating greater social support. Conclusions The participants endorsed drinking and smoking behaviors at levels consistent with other types of disability and with veterans using the Veterans Health Administration for their health care. Even with a variety of health concerns, after amputation, most of the smokers and those engaging in alcohol misuse continued to smoke and drink at their preamputation rate. The presence of social support may encourage health behavior change and is an important area for future research and intervention. C1 [Turner, Aaron P.; Williams, Rhonda M.; Henderson, Alison W.; Hakimi, Kevin N.; Czerniecki, Joseph M.] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. [Turner, Aaron P.; Williams, Rhonda M.; Hakimi, Kevin N.; Czerniecki, Joseph M.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Norvell, Daniel C.] Spectrum Res Inc, Tacoma, WA USA. [Blake, Donna Jo] Denver VAMC, Denver, CO USA. [Blake, Donna Jo] Univ Colorado, Denver, CO 80202 USA. RP Turner, AP (reprint author), VA Puget Sound Hlth Care Syst, RCS 117,1660 S Columbian Way, Seattle, WA 98108 USA. OI Turner, Aaron/0000-0001-6897-8003 FU United States Department of Veterans Affairs, Office of Research and Development, Rehabilitation Research and Development [A41241, B4927W] FX Supported by the United States Department of Veterans Affairs, Office of Research and Development, Rehabilitation Research and Development (Merit Review A41241, Joseph M. Czerniecki, PI, and Career Development Award B4927W, Aaron P. Turner, PI). NR 78 TC 1 Z9 1 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0894-9115 EI 1537-7385 J9 AM J PHYS MED REHAB JI Am. J. Phys. Med. Rehabil. PD JUN PY 2014 VL 93 IS 6 BP 493 EP 502 DI 10.1097/PHM.0000000000000055 PG 10 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI3FC UT WOS:000336744900005 PM 24508927 ER PT J AU Lee, JXW Yusin, JS Randhawa, I AF Lee, Joyce Xiang Wu Yusin, Joseph Stephen Randhawa, Inderpal TI Properdin deficiency-associated bronchiectasis SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter C1 [Lee, Joyce Xiang Wu; Yusin, Joseph Stephen] Vet Affairs Greater Los Angeles Healthcare Syst, Dept Allergy & Immunol, Los Angeles, CA 90073 USA. [Randhawa, Inderpal] Long Beach Mem Med Ctr, Long Beach, CA USA. RP Lee, JXW (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Dept Allergy & Immunol, Los Angeles, CA 90073 USA. EM joycexianglee@gmail.com NR 8 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 EI 1534-4436 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD JUN PY 2014 VL 112 IS 6 BP 557 EP 559 PG 6 WC Allergy; Immunology SC Allergy; Immunology GA AH9XJ UT WOS:000336498400017 PM 24793003 ER PT J AU Carbone, LD Chin, AS Lee, TA Burns, SP Svircev, JN Hoenig, HM Bailey, L Weaver, FM AF Carbone, Laura D. Chin, Amy S. Lee, Todd A. Burns, Stephen P. Svircev, Jelena N. Hoenig, Helen M. Bailey, Lauren Weaver, Frances M. TI Thiazide Use Is Associated With Reduced Risk for Incident Lower Extremity Fractures in Men With Spinal Cord Injury SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Fractures, bone; Men; Rehabilitation; Spinal cord injuries; Thiazides ID BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; HIP FRACTURE; OLDER-ADULTS; DIURETIC USE; VITAMIN-D; OSTEOPOROSIS; WORLDWIDE; VETERANS AB Objective: To determine the association between thiazide use and lower extremity fractures in patients who are men with a spinal cord injury (SCI). Design: Cohort study from fiscal years 2002 to 2007. Setting: Medical centers. Participants: Men (N=6969) with an SCI from the Veterans Affairs (VA) Spinal Cord Dysfunction (SCD) Registry, including 1433 users of thiazides and 5536 nonusers of thiazides. Intervention: Thiazide use versus nonuse. Main Outcome Measure: Incident lower extremity fractures. Results: Among the men, 21% in the VA SCD Registry (fiscal years 2002-2007) included in these analyses used thiazide diuretics. There were 832 incident lower extremity fractures over the time period of this study: 110 fractures (7.7%) in 1433 thiazide users and 722 fractures (13%) in 5536 nonusers of thiazides. In unadjusted and adjusted models alike, thiazide use was associated with at least a one-quarter risk reduction in lower extremity fracture at any given point in time (unadjusted: hazard ratio (HR)=.75; 95% confidence interval (CI), .59-.94; adjusted: HR=.74; 95% CI, .58-.95). Conclusions: Thiazide use is common in men with SCI and is associated with a decreased likelihood for lower extremity fractures. (C) 2014 by the American Congress of Rehabilitation Medicine C1 [Carbone, Laura D.] Charlie Norwood Vet Affairs Med Ctr, Augusta, GA USA. [Carbone, Laura D.] Georgia Regents Univ, Dept Med, Augusta, GA 30912 USA. [Chin, Amy S.; Lee, Todd A.; Bailey, Lauren; Weaver, Frances M.] Care of Hines EJ, Jr Vet Affairs Hosp, Hines, IL USA. [Lee, Todd A.; Bailey, Lauren] Univ Illinois, Chicago, IL USA. [Burns, Stephen P.; Svircev, Jelena N.] Vet Affairs Puget Sound, Spinal Cord Injury Serv, Seattle, WA USA. [Burns, Stephen P.; Svircev, Jelena N.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Hoenig, Helen M.] Durham Vet Affairs Med Ctr, Durham, NC USA. [Weaver, Frances M.] Loyola Univ, Stritch Sch Med, Maywood, IL 60153 USA. RP Carbone, LD (reprint author), Georgia Regents Univ, Dept Med, Sect Rheumatol & Immunol, 1120 15th St,BI 5086, Augusta, GA 30912 USA. EM lcarbone@gru.edu FU Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development [UR 08-033] FX Supported by the Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development (grant no. UR 08-033). NR 38 TC 2 Z9 2 U1 2 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 EI 1532-821X J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JUN PY 2014 VL 95 IS 6 BP 1015 EP 1020 DI 10.1016/j.apmr.2013.12.013 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI3OY UT WOS:000336773000002 PM 24378805 ER PT J AU Sullivan-Singh, SJ Sawyer, K Ehde, DM Bell, KR Temkin, N Dikmen, S Williams, RM Hoffman, JM AF Sullivan-Singh, Sarah J. Sawyer, Kathryn Ehde, Dawn M. Bell, Kathleen R. Temkin, Nancy Dikmen, Sureyya Williams, Rhonda M. Hoffman, Jeanne M. TI Comorbidity of Pain and Depression Among Persons With Traumatic Brain Injury SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Brain injuries; Depression; Pain; Rehabilitation ID CUT-POINTS; SEVERITY; DISORDERS; PREVALENCE; VALIDITY; OUTCOMES AB Objective: To assess the prevalence of pain, depression, and comorbid pain and depression among a civilian sample of persons with traumatic brain injury (TBI). Design: Longitudinal survey design with 1-year follow-up. Setting: Inpatient rehabilitation and the community. Participants: Participants (N = 158) admitted to inpatient rehabilitation after moderate to severe TBI. Interventions: Not applicable. Main Outcome Measures: Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9); pain was assessed with a numerical rating scale from 0 (no pain) to 10 (worst pain). Participants who reported average pain >= 4 were classified as having pain, and participants with PHQ-9 scores >= 10 were classified as depressed. Results: Both pain and depression were more prevalent at baseline assessment (pain: 70%; depression: 31%) than at year 1 (pain: 34%; depression: 22%). Comorbid pain and depression declined from 27% at baseline to 18% at year 1. Pain was significantly associated with depression at baseline (relative risk: 2.62, P = .003) and at year 1 (relative risk: 7.98, P<.001). Conclusions: Pain and depression are common and frequently co-occur in persons with TBI. Although their frequency declined over the first year after injury, the strength of their association increased. Assessment and treatment of both conditions simultaneously may lead to improved outcomes, both early after TBI and over time. (C) 2014 by the American Congress of Rehabilitation Medicine C1 [Sullivan-Singh, Sarah J.; Sawyer, Kathryn; Ehde, Dawn M.; Bell, Kathleen R.; Temkin, Nancy; Dikmen, Sureyya; Williams, Rhonda M.; Hoffman, Jeanne M.] Univ Washington, Dept Rehabil Med, Sch Med, Seattle, WA 98104 USA. [Temkin, Nancy; Dikmen, Sureyya] Univ Washington, Dept Neurol Surg, Sch Med, Seattle, WA 98104 USA. [Temkin, Nancy] Univ Washington, Dept Biostat, Sch Med, Seattle, WA 98104 USA. [Dikmen, Sureyya] Univ Washington, Dept Psychiat & Biobehav Sci, Sch Med, Seattle, WA 98104 USA. [Williams, Rhonda M.] Vet Affairs Puget Sound Healthcare Syst, Rehabil Care Serv, Seattle, WA USA. RP Sullivan-Singh, SJ (reprint author), Univ Washington, Dept Rehabil Med, Harborview Med Ctr, 325 Ninth Ave,Box 359612, Seattle, WA 98104 USA. EM sarahsullivansingh@gmail.com FU National Institute on Disability and Rehabilitation Research Traumatic Brain Injury Model Systems [H133A070032]; Department of Defense Congressionally Directed Medical Research Programs [W81XWH-12-2-0109] FX Supported by the National Institute on Disability and Rehabilitation Research Traumatic Brain Injury Model Systems (grant no. H133A070032) and Department of Defense Congressionally Directed Medical Research Programs (grant no. W81XWH-12-2-0109). NR 27 TC 11 Z9 11 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 EI 1532-821X J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JUN PY 2014 VL 95 IS 6 BP 1100 EP 1105 DI 10.1016/j.apmr.2014.02.001 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI3OY UT WOS:000336773000014 PM 24561058 ER PT J AU Abern, MR Terris, MK Aronson, WJ Kane, CJ Amling, CL Cooperberg, MR Freedland, SJ AF Abern, Michael R. Terris, Martha K. Aronson, William J. Kane, Christopher J. Amling, Christopher L. Cooperberg, Matthew R. Freedland, Stephen J. TI The Impact of Pathologic Staging on the Long-Term Oncologic Outcomes of Patients With Clinically High-Risk Prostate Cancer SO CANCER LA English DT Article DE prostatic neoplasms; prostatectomy; treatment outcome; pathology ID RADICAL PROSTATECTOMY; UNITED-STATES; MORTALITY; NOMOGRAM; SURVIVAL; DISEASE; NG/ML; MEN AB BACKGROUNDIn the prostate-specific antigen (PSA) screening era, approximately 15% of US men still present with clinically high-risk prostate cancer (PC). However, high-risk PC may be downgraded/downstaged at radical prostatectomy (RP), making additional therapy unnecessary. The authors tested the oncologic outcomes in men with clinically high-risk disease stratified on RP pathology. METHODSA total of 611 men with high-risk PC (PSA level>20 ng/mL, biopsy Gleason sum [bGS]8, or clinical classification ofT3) underwent RP and pelvic lymphadenectomy between 1998 and 2011. Outcomes included biochemical disease recurrence (BCR), receipt of androgen deprivation therapy (ADT), metastases, and PC-specific and overall survival. RP pathology was classified as unfavorable (pathologic Gleason sum8, pathologic classification ofT3, or lymph node-positive disease), or favorable (no unfavorable features). Multivariable analyses tested oncologic outcomes stratified by pathologic classification. RESULTSOverall, 527 men had complete pathologic data and were included in the current analysis. Of the cohort, 206 of 527 men (39%) had favorable pathology. This finding was more common in men with only 1 clinical high-risk feature, and a lower body mass index, PSA level, bGS, and percentage positive biopsy cores. Favorable pathology was associated with decreased BCR (hazards ratio [HR], 0.34), metastases (HR, 0.17), and PC death (HR, 0.17). After a median follow-up of 82 months (range, 49 months-131 months), 193 of the 527 men (37%) received ADT, including only 35 of the 206 men with favorable pathology (17%). Unfavorable pathology was associated with early ( 5 years) but not late treatment with ADT. CONCLUSIONSIn a large cohort of men with high-risk PC who were managed with RP, 39% had favorable pathology and superior oncologic outcomes. Cancer 2014;120:1656-1662. (c) 2014 American Cancer Society. C1 [Abern, Michael R.] Univ Illinois, Dept Urol, Chicago, IL 60612 USA. [Terris, Martha K.] Vet Affairs Med Ctr, Urol Sect, Augusta, GA USA. [Terris, Martha K.] Med Coll Georgia, Urol Sect, Augusta, GA 30912 USA. [Aronson, William J.] Vet Affairs Greater Los Angeles Healthcare Syst, Urol Sect, Dept Surg, Los Angeles, CA USA. [Aronson, William J.] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA USA. [Kane, Christopher J.] Univ Calif San Diego, Div Urol, San Diego, CA 92103 USA. [Amling, Christopher L.] Oregon Hlth & Sci Univ, Dept Urol, Portland, OR USA. [Cooperberg, Matthew R.] Univ Calif San Francisco, Ctr Comprehens Canc, Dept Urol, San Francisco, CA 94143 USA. [Cooperberg, Matthew R.] Vet Affairs Med Ctr, Dept Surg, Urol Sect, San Francisco, CA 94121 USA. [Freedland, Stephen J.] Vet Affairs Med Ctr, Urol Sect, Durham, NC USA. [Freedland, Stephen J.] Duke Univ, Sch Med, Dept Surg, Div Urol Surg, Durham, NC USA. RP Abern, MR (reprint author), Univ Illinois, Dept Urol, 820 S Wood St,Suite 515, Chicago, IL 60612 USA. EM mabern1@uic.edu OI Terris, Martha/0000-0002-3843-7270 NR 23 TC 10 Z9 11 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD JUN 1 PY 2014 VL 120 IS 11 BP 1656 EP 1662 DI 10.1002/cncr.28647 PG 7 WC Oncology SC Oncology GA AI1OE UT WOS:000336619700014 PM 24647966 ER PT J AU O'Horo, JC Maki, DG Krupp, AE Safdar, N AF O'Horo, John C. Maki, Dennis G. Krupp, Anna E. Safdar, Nasia TI Arterial Catheters as a Source of Bloodstream Infection: A Systematic Review and Meta-Analysis SO CRITICAL CARE MEDICINE LA English DT Article DE arterial catheterization; catheter-related infections; critical care; meta-analysis; nosocomial infections; peripheral; prevalence ID CRITICALLY-ILL PATIENTS; RANDOMIZED CONTROLLED-TRIAL; CENTRAL VENOUS CATHETERS; INTENSIVE-CARE UNITS; RADIAL-ARTERY; FEMORAL-ARTERY; CARDIAC-SURGERY; COLONIZATION; CANNULATION; SEPSIS AB Objective: Catheter-related bloodstream infections are associated with significant costs and adverse consequences. Arterial catheters are commonly used in the critical care setting and are among the most heavily manipulated vascular access devices. We sought to evaluate the prevalence of arterial catheter-related bloodstream infection. Data Sources: PubMed, CinAHL, EMBASE, and Web of Science. Study Selection: Included studies reported prevalence rate of catheter-related bloodstream infection for arterial catheters used for critical illness or postoperative monitoring. For the purposes of this study, catheter-related bloodstream infection was defined as positive blood culture collected from an arterial catheter and from the periphery with the same organism in a patient demonstrating systemic signs of sepsis. Data Extraction: The study population, site of insertion, antiseptic preparation, catheter days, and prevalence of catheter-related bloodstream infection were abstracted. When data were not available, authors were contacted for further information. Data Synthesis: Forty-nine studies met criteria including 222 cases of arterial catheter-related bloodstream infection in 30,841 catheters. Pooled incidence was 3.40/1,000 catheters or 0.96/1,000 catheter days. Prevalence was considerably higher in the subgroup of studies that cultured all catheters (1.26/1,000 catheter days) compared with those studies that cultured only when the arterial catheter was suspected as the source for the catheter-related bloodstream infection (0.70/1,000 catheter days). Pooled data also found a significantly increased risk of infection for femoral site of insertion compared with radial artery for arterial catheter placement (relative risk, 1.93; 95% CI, 1.32-2.84; p = 0.001) Conclusions: Arterial catheters are an underrecognized cause of catheter-related bloodstream infection. Pooled incidence when catheters were systematically cultured and correlated to blood culture results indicated a substantial burden of arterial catheter-related bloodstream infection. Selection of a radial site over a femoral site will help reduce the risk of arterial catheter-related bloodstream infection. Future studies should evaluate technologies applied to preventing central venous catheter-related bloodstream infection to arterial catheters as well. C1 [O'Horo, John C.] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA. [Maki, Dennis G.; Safdar, Nasia] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. [Krupp, Anna E.; Safdar, Nasia] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Sect Infect Dis, Madison, WI USA. [Safdar, Nasia] Univ Wisconsin Hosp & Clin, Madison, WI 53792 USA. RP Safdar, N (reprint author), UW Med Fdn Centennial Bldg,1685 Highland Ave, Madison, WI 53705 USA. EM ns2@medicine.wisc.edu RI O'Horo, John/N-8681-2013 OI O'Horo, John/0000-0002-0880-4498 NR 62 TC 25 Z9 26 U1 2 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 2014 VL 42 IS 6 BP 1334 EP 1339 DI 10.1097/CCM.0000000000000166 PG 6 WC Critical Care Medicine SC General & Internal Medicine GA AH6UM UT WOS:000336266900016 PM 24413576 ER PT J AU Inoue, T Higashiyama, M Kaji, I Rudenkyy, S Higuchi, K Guth, PH Engel, E Kaunitz, JD Akiba, Y AF Inoue, Takuya Higashiyama, Masaaki Kaji, Izumi Rudenkyy, Sergiy Higuchi, Kazuhide Guth, Paul H. Engel, Eli Kaunitz, Jonathan D. Akiba, Yasutada TI Dipeptidyl Peptidase IV Inhibition Prevents the Formation and Promotes the Healing of Indomethacin-Induced Intestinal Ulcers in Rats SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE Glucagon-like peptide-2; NSAIDs; Taste receptor ID GLUCAGON-LIKE PEPTIDE-2; SHORT-BOWEL SYNDROME; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GROWTH-FACTOR-I; INDUCED ENTEROPATHY; ENTERAL NUTRIENTS; BICARBONATE SECRETION; AMINO-ACID; BLOOD-LOSS; GLP-2 AB We studied the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) as a possible therapy for non-steroidal anti-inflammatory drug (NSAID)-induced intestinal ulcers. Luminal nutrients release endogenous GLP-2 from enteroendocrine L cells. Since GLP-2 is degraded by dipeptidyl peptidase IV (DPPIV), we hypothesized that DPPIV inhibition combined with luminal administration of nutrients potentiates the effects of endogenous GLP-2 on intestinal injury. Intestinal injury was induced by indomethacin (10 mg/kg, sc) in fed rats. The long-acting DPPIV inhibitor K579 was given intragastrically (ig) or intraperitoneally (ip) before or after indomethacin treatment. l-Alanine (l-Ala) and inosine 5'-monophosphate (IMP) were co-administered ig after the treatment. Indomethacin treatment induced intestinal ulcers that gradually healed after treatment. Pretreatment with ig or ip K579 given at 1 mg/kg reduced total ulcer length, whereas K579 at 3 mg/kg had no effect. Exogenous GLP-2 also reduced intestinal ulcers. The preventive effect of K579 was dose-dependently inhibited by a GLP-2 receptor antagonist. Daily treatment with K579 (1 mg/kg), GLP-2, or l-Ala + IMP after indomethacin treatment reduced total ulcer length. Co-administration (ig) of K579 and l-Ala + IMP further accelerated intestinal ulcer healing. DPPIV inhibition and exogenous GLP-2 prevented the formation and promoted the healing of indomethacin-induced intestinal ulcers, although high-dose DPPIV inhibition reversed the preventive effect. Umami receptor agonists also enhanced the healing effects of the DPPIV inhibitor. The combination of DPPIV inhibition and luminal nutrient-induced GLP-2 release may be a useful therapeutic tool for the treatment of NSAIDs-induced intestinal ulcers. C1 [Inoue, Takuya; Higashiyama, Masaaki; Kaji, Izumi; Kaunitz, Jonathan D.; Akiba, Yasutada] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Inoue, Takuya; Higuchi, Kazuhide] Osaka Med Coll, Dept Internal Med 2, Osaka, Japan. [Rudenkyy, Sergiy; Guth, Paul H.; Kaunitz, Jonathan D.; Akiba, Yasutada] Greater Los Angles Vet Affairs Healthcare Syst, Los Angeles, CA USA. [Engel, Eli] Univ Calif Los Angeles, Dept Biomath, Los Angeles, CA USA. [Kaunitz, Jonathan D.; Akiba, Yasutada] Brentwood Biomed Res Inst, Los Angeles, CA 90073 USA. [Kaunitz, Jonathan D.] West Los Angeles VA Med Ctr, Los Angeles, CA 90073 USA. RP Kaunitz, JD (reprint author), West Los Angeles VA Med Ctr, Bldg 114,Suite 217,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM jake@ucla.edu FU Department of Veterans Affairs Merit Review Award, NIH-NIDDK [R01 DK54221]; NIH-NIDDK [P30 DK0413] FX We thank Coleen and Bea Palileo for their assistance with manuscript preparation. Supported by the Department of Veterans Affairs Merit Review Award, NIH-NIDDK R01 DK54221 (J. Kaunitz), and the animal core of NIH-NIDDK P30 DK0413 (J.E. Rozengurt). NR 53 TC 12 Z9 12 U1 0 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 EI 1573-2568 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD JUN PY 2014 VL 59 IS 6 BP 1286 EP 1295 DI 10.1007/s10620-013-3001-6 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AH8KF UT WOS:000336386000031 PM 24379150 ER PT J AU Hildebrandt, T Shope, S Varangis, E Klein, D Pfaff, DW Yehuda, R AF Hildebrandt, Tom Shope, Sydney Varangis, Eleanna Klein, Diane Pfaff, Donald W. Yehuda, Rachel TI Exercise reinforcement, stress, and beta-endorphins: An initial examination of exercise in anabolic-androgenic steroid dependence SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE Anabolic androgenic steroids; beta-endorphin; Cortisol; ACTH; Compulsive exercise; Drug dependence ID HEAVY-RESISTANCE EXERCISE; HEALTHY-YOUNG MEN; ACUTE HORMONAL RESPONSES; GROWTH-FACTOR RESPONSES; RAT-BRAIN; NANDROLONE DECANOATE; ANOREXIA-NERVOSA; PLASMA-CORTISOL; DOSE-RESPONSE; MALE HAMSTERS AB Background: Anabolic-androgenic steroids (AASs) are abused primarily in the context of intense exercise and for the purposes of increasing muscle mass as opposed to drug-induced euphoria. AASs also modulate the HPA axis and may increase the reinforcing value of exercise through changes to stress hormone and endorphin release. To test this hypothesis, 26 adult males drawn from a larger study on AAS use completed a progressive ratio task designed to examine the reinforcing value of exercise relative to financial reinforcer. Method: Sixteen experienced and current users (8 on-cycle, 8 off-cycle) and 10 controls matched on quantity x frequency of exercise, age, and education abstained from exercise for 24 h prior to testing and provided 24-h cortisol, plasma cortisol, ACTH, beta-endorphin samples, and measures of mood, compulsive exercise, and body image. Results: Between group differences indicated that on-cycle AAS users had the highest beta-endorphin levels, lowest cortisol levels, higher ACTH levels than controls. Conversely, off-cycle AAS users had the highest cortisol and ACTH levels, but the lowest beta-endorphin levels. Exercise value was positively correlated with beta-endorphin and symptoms of AAS dependence. Conclusion: The HPA response to AASs may explain why AASs are reinforcing in humans and exercise may play a key role in the development of AAS dependence. (C) 2014 Elsevier Ireland Ltd. All rights reserved. C1 [Hildebrandt, Tom; Shope, Sydney; Varangis, Eleanna; Yehuda, Rachel] Ichan Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. [Klein, Diane] NYU, Dept Psychiat, New York, NY 10016 USA. [Pfaff, Donald W.] Rockefeller Univ, New York, NY 10021 USA. [Yehuda, Rachel] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. RP Hildebrandt, T (reprint author), Ichan Sch Med Mt Sinai, Eating & Weight Disorders Program, Dept Psychiat, One Gustave Levy Pl,Box 1230, New York, NY 10029 USA. EM hildebtb@hotmail.com OI Hildebrandt, Thomas/0000-0001-7054-9590 FU NIDA K23 grant [DA024043] FX Funds for this study were provided by NIDA K23 grant DA024043 awarded to Dr. Hildebrandt. NIDA had no influence over the study design, execution of the project, interpretation or results, or manuscript preparation. NR 58 TC 1 Z9 1 U1 0 U2 24 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 EI 1879-0046 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD JUN 1 PY 2014 VL 139 BP 86 EP 92 DI 10.1016/j.drugalcdep.2014.03.008 PG 7 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA AI2SI UT WOS:000336708000012 PM 24690349 ER PT J AU Lin, F Roiland, R Heffner, K Johnson, M Chen, DG Mapstone, M AF Lin, Feng Roiland, Rachel Heffner, Kathi Johnson, Melissa Chen, Ding-Geng (Din) Mapstone, Mark TI Evaluation of objective and perceived mental fatigability in older adults with vascular risk SO JOURNAL OF PSYCHOSOMATIC RESEARCH LA English DT Article DE Mental fatigability; Executive control; History of mental activities; Reaction time ID COGNITIVE FATIGUE; SUBSEQUENT SYMPTOMS; MULTIPLE-SCLEROSIS; SUBJECTIVE FATIGUE; NORMATIVE DATA; HEART-FAILURE; AGE; EDUCATION; SAMPLE; MEMORY AB Objectives: Mental fatigability refers to the failure to sustain participation in tasks requiring mental effort Older adults with vascular risk are at particular risk for experiencing mental fatigability. The present study (1) tested a new way of measuring objective mental fatigability by examining its association with perceived mental fatigability; and (2) identified associated psychological, physiological, and situational predictors. Methods: A cross-sectional study was conducted with 49 community-dwelling participants aged 75 + years with vascular risk. A 20-minute fatigability-manipulation task was used to induce mental fatigability and develop objective and perceived mental fatigability measures. Objective fatigability was calculated by the change of reaction time over the course of the task. Perceived fatigability was calculated by the change of fatigue self-reported before and after the task. A set of potential psychological, physiological, and situational predictors were measured. Results: There was a significant increase in reaction time and self-reported fatigue to the fatigability manipulation task, indicating occurrence of objective and perceived mental fatigability. Reaction time and self-reported fatigue were moderately, but significantly correlated. Higher levels of executive control and having a history of more frequently engaging in mental activities were associated with lower objective mental fatigability. None of the examined factors were associated with perceived mental fatigability. Conclusion: Objective and perceived mental fatigability were sensitive to our fatigability-manipulation task. While these two measures were correlated, they were not associated with the same factors. These findings need to be validated in studies with a more heterogeneous sample and a greater variety of fatigability-manipulation tasks. (C) 2014 Elsevier Inc. All rights reserved. C1 [Lin, Feng; Johnson, Melissa; Chen, Ding-Geng (Din)] Univ Rochester, Sch Nursing, Rochester, NY 14642 USA. [Lin, Feng; Heffner, Kathi] Univ Rochester, Dept Psychiat, Sch Med & Dent, Rochester, NY 14642 USA. [Roiland, Rachel] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. [Chen, Ding-Geng (Din)] Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY 14642 USA. [Mapstone, Mark] Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA. RP Lin, F (reprint author), Univ Rochester, Med Ctr, HWH 2w128,601 Elmwood Ave, Rochester, NY 14642 USA. EM vankee_lin@urmc.rochester.edu OI Heffner, Kathi/0000-0003-1095-1873 FU University of Rochester CTSA from the National Center for Advancing Translational Sciences of the National Institutes of Health [KL2 TR000095]; Sigma Theta Tau International Small Grants FX Data collection of the present project was supported by Sigma Theta Tau International Small Grants to F. Lin. The manuscript preparation was supported by the University of Rochester CTSA award number KL2 TR000095 from the National Center for Advancing Translational Sciences of the National Institutes of Health to F. Lin. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 52 TC 0 Z9 0 U1 3 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3999 EI 1879-1360 J9 J PSYCHOSOM RES JI J. Psychosomat. Res. PD JUN PY 2014 VL 76 IS 6 BP 458 EP 464 DI 10.1016/j.jpsychores.2014.04.001 PG 7 WC Psychiatry SC Psychiatry GA AI1UA UT WOS:000336639300004 PM 24840140 ER PT J AU Cox, K McAdams, DP AF Cox, Keith McAdams, Dan P. TI Meaning making during high and low point life story episodes predicts emotion regulation two years later: How the past informs the future SO JOURNAL OF RESEARCH IN PERSONALITY LA English DT Article DE Narrative identity; Emotion regulation; Emotional memory ID AUTOBIOGRAPHICAL MEMORIES; ADOLESCENCE AB Memory processes are commonly thought to relate to a host of personality systems. The current study specifies a particular way that memory relates to personality. Highly-valenced, identity-rich memories - high and low point episodes in the life story - were analyzed to see if aspects of these memories predicted self-reports of emotion regulation two years later. Meaning making in high and low points predicted emotion regulation. Moreover, valence mattered. Positive meaning making in high and low point stories predicted positive emotion regulation while negative meaning making in low point stories predicted negative emotion regulation. These relationships held while controlling for baseline extraversion, neuroticism, and memory word count. Limitations due to study design are discussed. Published by Elsevier Inc. C1 [Cox, Keith] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Cox, Keith] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC USA. [McAdams, Dan P.] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA. [McAdams, Dan P.] Sch Educ & Social Policy, Evanston, IL USA. RP Cox, K (reprint author), Ralph H Johnson VA Med Ctr, Charleston, SC USA. EM keith.cox@va.gov NR 14 TC 13 Z9 13 U1 3 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0092-6566 EI 1095-7251 J9 J RES PERS JI J. Res. Pers. PD JUN PY 2014 VL 50 BP 66 EP 70 DI 10.1016/j.jrp.2014.03.004 PG 5 WC Psychology, Social SC Psychology GA AI2TA UT WOS:000336709800009 ER PT J AU Bent, S Hendren, RL Zandi, T Law, K Choi, JE Widjaja, F Kalb, L Nestle, J Law, P AF Bent, Stephen Hendren, Robert L. Zandi, Tara Law, Kiely Choi, Jae-Eun Widjaja, Felicia Kalb, Luther Nestle, Jay Law, Paul TI Internet-Based, Randomized, Controlled Trial of Omega-3 Fatty Acids for Hyperactivity in Autism SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE autism; nutritional supplement; alternative medicine; hyperactivity ID PERVASIVE DEVELOPMENTAL DISORDERS; PLACEBO-CONTROLLED-TRIAL; SPECTRUM DISORDERS; PARENT REPORT; CHILDREN; METHYLPHENIDATE; SUPPLEMENTATION; IRRITABILITY; ARIPIPRAZOLE; RISPERIDONE AB Objective: Preliminary evidence suggests that omega-3 fatty acids may reduce hyperactivity in children with autism spectrum disorder (ASD). We sought to examine the feasibility of a novel, Internet-based clinical trial design to evaluate the efficacy of this supplement. Method: E-mail invitations were sent to parents of children aged 5 to 8 years enrolled in the Interactive Autism Network. All study procedures, including screening, informed consent, and collection of outcome measures took place over the Internet. The primary Outcome measures were parent- and teacher-rated changes in hyperactivity on the Aberrant Behavior Checklist (ABC-H). Results: During the 6-week recruitment period, 57 children from 28 states satisfied all eligibility criteria and were randomly assigned to 1.3 grams of omega-3 fatty acids or an identical placebo daily for 6 weeks. Outcome assessments were obtained from all 57 participants and 57 teachers, and the study was completed in 3 months. Children in the omega-3 fatty acid group had a greater reduction in hyperactivity (-5.3 points) compared to the placebo group (-2.6 points), but the difference was not statistically significant (1.9-point greater improvement in the omega-3 group, 95% CI = -2.2 to 5.2). Adverse events were rare and not associated with omega-3 fatty acids. Participant feedback was positive. Conclusion: Internet-based, randomized controlled trials of therapies in children with ASD are feasible and may lead to marked reductions in the time and cost of completing trials. A larger sample size is required to definitively determine the efficacy of omega-3 fatty acids. Clinical trial registration information-Omega-3 Fatty Acids for Hyperactivity Treatment in Autism Spectrum Disorder; http://clinicaltrials.gov; NCT 01694667. C1 [Bent, Stephen; Hendren, Robert L.; Choi, Jae-Eun; Widjaja, Felicia] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Zandi, Tara; Law, Kiely; Kalb, Luther; Nestle, Jay; Law, Paul] Kennedy Krieger Inst, Baltimore, MD USA. RP Bent, S (reprint author), San Francisco VA Med Ctr, 111-A1,4150 Clement St, San Francisco, CA 94121 USA. EM Stephen.Bent@ucsf.edu FU Simons Foundation [SFARI 206484]; National Center for Research Resources; National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI [UL1 RR024131] FX This work was supported by a grant from the Simons Foundation (SFARI 206484, S.B.) and by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1 RR024131. NR 25 TC 10 Z9 11 U1 1 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0890-8567 EI 1527-5418 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD JUN PY 2014 VL 53 IS 6 BP 658 EP 666 DI 10.1016/j.jaac.2014.01.018 PG 9 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA AI0SO UT WOS:000336560400009 PM 24839884 ER PT J AU Jesinkey, SR Funk, JA Stallons, LJ Wills, LP Megyesi, JK Beeson, CC Schnellmann, RG AF Jesinkey, Sean R. Funk, Jason A. Stallons, L. Jay Wills, Lauren P. Megyesi, Judit K. Beeson, Craig C. Schnellmann, Rick G. TI Formoterol Restores Mitochondrial and Renal Function after Ischemia-Reperfusion Injury SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE KIDNEY INJURY; OXIDANT INJURY; TRANSCRIPTIONAL COACTIVATOR; PROMOTES RECOVERY; PROXIMAL TUBULES; BIOGENESIS; PGC-1-ALPHA; DISEASE; EXPRESSION; REGULATOR AB Mitochondrial biogenesis may be an adaptive response necessary for meeting the increased metabolic and energy demands during organ recovery after acute injury, and renal mitochondrial dysfunction has been implicated in the pathogenesis of AKI. We proposed that stimulation of mitochondria! biogenesis 24 hours after ischemia/reperfusion (I/R)-induced AKI, when renal dysfunction is maximal, would accelerate recovery of mitochondrial and renal function in mice. We recently showed that formoterol, a potent, highly specific, and long-acting beta(2)-adrenergic agonist, induces renal mitochondrial biogenesis in naive mice. Animals were subjected to sham or I/R-induced AKI, followed by once-daily intraperitoneal injection with vehicle or formoterol beginning 24 hours after surgery and continuing through 144 hours after surgery. Treatment with formoterol restored renal function, rescued renal tubules from injury, and diminished necrosis after I/R-induced AKI. Concomitantly, formoterol stimulated mitochondrial biogenesis and restored the expression and function of mitochondrial proteins. Taken together, these results provide proof of principle that a novel drug therapy to treat AKI, and potentially other acute organ failures, works by restoring mitochondrial function and accelerating the recovery of renal function after injury has occurred. C1 [Jesinkey, Sean R.; Funk, Jason A.; Stallons, L. Jay; Wills, Lauren P.; Beeson, Craig C.; Schnellmann, Rick G.] Med Univ S Carolina, Ctr Cell Death Injury & Regenerat, Dept Drug Discovery & Biomed Sci, Charleston, SC 29425 USA. [Megyesi, Judit K.] Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA. [Schnellmann, Rick G.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. RP Schnellmann, RG (reprint author), MUSC MSC 140,280 Calhoun St, Charleston, SC 29425 USA. EM schnell@musc.edu FU National Institutes of Health [R01 GM084147, T32 HL007260-35, F32DK098053, C06 RR015455, P20 GM103542-02, UL1 RR029882]; Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs [BX-000851]; South Carolina Clinical and Translational Research Institute FX This study was supported by the National Institutes of Health (R01 GM084147 to R.G.S., T32 HL007260-35 to S.R.J and L.J.S., F32DK098053 to L.J.S., C06 RR015455 and SC COBRE in Oxidants, Redox Balance and Stress Signaling P20 GM103542-02), and by the Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs (BX-000851). This publication was supported, in part, by the South Carolina Clinical and Translational Research Institute, with an academic home at the Medical University of South Carolina CTSA, and funded by the National Institutes of Health (UL1 RR029882). NR 30 TC 20 Z9 20 U1 0 U2 5 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 EI 1533-3450 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD JUN PY 2014 VL 25 IS 6 BP 1157 EP 1162 DI 10.1681/ASN.2013090952 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA AI0RS UT WOS:000336558100007 PM 24511124 ER PT J AU Funk, JA Janech, MG Dillon, JC Bissler, JJ Siroky, BJ Bell, PD AF Funk, Jason A. Janech, Michael G. Dillon, Joshua C. Bissler, John J. Siroky, Brian J. Bell, P. Darwin TI Characterization of Renal Toxicity in Mice Administered the Marine Biotoxin Domoic Acid SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE KIDNEY INJURY; LIONS ZALOPHUS-CALIFORNIANUS; SEA LIONS; C-FOS; RECEPTOR ANTAGONIST; TISSUE DISTRIBUTION; SUBCLINICAL AKI; GENE-EXPRESSION; NMDA RECEPTORS; SHELLFISH AB Domoic acid (DA), an excitatory amino acid produced by diatoms belonging to the genus Pseudo-nitzschia, is a glutamate analog responsible for the neurologic condition referred to as amnesic shellfish poisoning. To date, the renal effects of DA have been underappreciated, although renal filtration is the primary route of systemic elimination and the kidney expresses ionotropic glutamate receptors. To characterize the renal effects of DA, we administered either a neurotoxic dose of DA or doses below the recognized limit of toxicity to adult Sv128/Black Swiss mice. DA preferentially accumulated in the kidney and elicited marked renal vascular and tubular damage consistent with acute tubular necrosis, apoptosis, and renal tubular cell desquamation, with toxic vacuolization and mitochondrial swelling as hallmarks of the cellular damage. Doses >= 0.1 mg/kg DA elevated the renal injury biomarkers kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin, and doses >= 0.005 mg/kg induced the early response genes c-fos and junb. Coadministration of DA with the broad spectrum excitatory amino acid antagonist kynurenic acid inhibited induction of c-fos, junb, and neutrophil gelatinase-associated lipocalin. These findings suggest that the kidney may be susceptible to excitotoxic agonists, and renal effects should be considered when examining glutamate receptor activation. Additionally, these results indicate that DA is a potent nephrotoxicant, and potential renal toxicity may require consideration when determining safe levels for human exposure. C1 [Funk, Jason A.; Janech, Michael G.; Dillon, Joshua C.; Bell, P. Darwin] Med Univ S Carolina, Div Nephrol, Dept Med, Charleston, SC 29425 USA. [Bissler, John J.; Siroky, Brian J.] Cincinnati Childrens Hosp Med Ctr, Div Nephrol & Hypertens, Cincinnati, OH 45229 USA. [Bell, P. Darwin] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. RP Bell, PD (reprint author), Med Univ S Carolina, 70 President St,DDB 514,MSC 629, Charleston, SC 29425 USA. EM bellpd@musc.edu OI Janech, Michael/0000-0002-3202-4811 FU National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases [T32DK007752]; Office of Naval Research [N000140810341]; Veterans Affairs Merit Grant [P30 DK074038]; Dialysis Clinic FX J.A.F. was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Training Grant T32DK007752 in Renal Function and Disease. M.G.J. was supported by Office of Naval Research Award N000140810341. This study was supported by Veterans Affairs Merit Grant P30 DK074038 and funds from Dialysis Clinic (to P.D.B.). NR 58 TC 8 Z9 8 U1 0 U2 14 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 EI 1533-3450 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD JUN PY 2014 VL 25 IS 6 BP 1187 EP 1197 DI 10.1681/ASN.2013080836 PG 11 WC Urology & Nephrology SC Urology & Nephrology GA AI0RS UT WOS:000336558100010 PM 24511141 ER PT J AU Decramer, M Anzueto, A Kerwin, E Kaelin, T Richard, N Crater, G Tabberer, M Harris, S Church, A AF Decramer, Marc Anzueto, Antonio Kerwin, Edward Kaelin, Thomas Richard, Nathalie Crater, Glenn Tabberer, Maggie Harris, Stephanie Church, Alison TI Efficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: results from two multicentre, blinded, randomised controlled trials SO LANCET RESPIRATORY MEDICINE LA English DT Article ID REFERENCE VALUES; COPD PATIENTS; DYSPNEA; SALMETEROL; BRONCHODILATION; QUESTIONNAIRE; INDACATEROL; SHORTNESS; SAMPLE; BREATH AB Background Combination long-acting bronchodilator treatment might be more effective than long-acting bronchodilator monotherapy for the treatment of chronic obstructive pulmonary disease (COPD). We aimed to compare the efficacy and safety of umeclidinium (UMEC) plus vilanterol (VI) with tiotropium (TIO) monotherapy, UMEC monotherapy, or VI monotherapy in patients with moderate to very severe COPD. Methods In two multicentre, randomised, blinded, double-dummy, parallel-group, active-controlled trials, eligible patients (current or former smokers aged 40 years or older with an established clinical history of COPD) were randomly assigned in 1:1:1:1 ratio to UMEC 125 mu g plus VI 25 mu g, UMEC 62.5 mu g plus VI 25 mu g, TIO 18 mu g, and either VI 25 mu g (study 1) or UMEC 125 mu g (study 2). All study drugs were used once daily for 24 weeks. TIO was delivered via the HandiHaler inhaler and all other active treatments were delivered via the ELLIPTA dry powder inhaler. Random assignment (by a validated computer-based system) was done by centre and was not stratified. All patients and physicians were masked to assigned treatment during the studies. The primary efficacy endpoint of both studies was trough forced expiratory volume in 1 s (FEV1) on day 169, which was analysed in the intention-to-treat population. Both studies are registered with ClinicalTrials.gov, numbers NCT01316900 (study 1) and NCT01316913 (study 2). Findings 1141 participants were recruited in study 1, and 1191 in study 2. For study 1, after exclusions, 208, 209, 214, and 212 patients were included in the intention-to-treat analyses for TIO monotherapy, VI monotherapy, UMEC 125 mu g plus VI 25 mu g, and UMEC 62.5 mu g plus VI 25 mu g, respectively. For study 2, 215, 222, 215, and 217 patients were included in the intention-to-treat analyses for TIO monotherapy, UMEC monotherapy, UMEC 125 mu g plus VI 25 mu g, and UMEC 62.5 mu g plus VI 25 mu g, respectively. In both studies, we noted improvements in trough FEV1 on day 169 for both doses of UMEC plus VI compared with TIO monotherapy (study 1, UMEC 125 mu g plus VI 25 mu g: 0.088 L [95% CI 0.036 to 0.140; p=0.0010]; study 1, UMEC 62.5 mu g plus VI 25 mu g: 0.090 L [0.039 to 0.141; p=0.0006]; study 2, UMEC 125 mu g plus VI 25 mu g: 0.074 L [0.025 to 0.123; p=0.0031]; study 2, UMEC 62.5 mu g plus VI 25 mu g: 0.060 L [0.010 to 0.109; nominal p=0.0182]). Both doses of UMEC plus VI also improved trough FEV1 compared with VI monotherapy (UMEC 125 mu g plus VI 25 mu g: 0.088 L [0.036 to 0.140; p=0.0010]; UMEC 62.5 mu g plus VI 25 mu g: 0.090 L [0.039 to 0.142; p=0.0006], but not compared with UMEC 125 mu g monotherapy (UMEC 125 mu g plus VI 25 mu g: 0.037 L [-0.012 to 0.087; p=0.14]; UMEC 62.5 mu g plus VI 25 mu g: 0.022 L [-0.027 to 0.072; p=0.38]). All treatments produced improvements in dyspnoea and health-related quality of life; we noted no significant differences in symptoms, health status, or risk of exacerbation between UMEC plus VI and TIO. The most common on-treatment, severe-intensity adverse event in both studies was acute exacerbation of COPD (1-4 [<1-2%] patients across treatment groups in study 1 and 1-6 [<1-3%] patients in study 2). We recorded five to 15 (2-7%) on-treatment serious adverse events across treatment groups in study 1, and nine to 22 (4-10%) in study 2. We noted no substantial changes from baseline in vital signs, clinical laboratory findings, or electrocardiography findings in any of the treatment groups. Interpretation Combination treatment with once-daily UMEC plus VI improved lung function compared with VI monotherapy and TIO monotherapy in patients with COPD. Overall our results suggest that the combination of UMEC plus VI could be beneficial for the treatment of moderate to very severe COPD. C1 [Decramer, Marc] Univ Louvain, Div Resp, Univ Hosp, B-3000 Louvain, Belgium. [Anzueto, Antonio] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Anzueto, Antonio] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Kerwin, Edward] Clin Res Inst Southern Oregon, Medford, OR USA. [Kaelin, Thomas] Lowcountry Lung & Crit Care, Charleston, SC USA. [Richard, Nathalie; Harris, Stephanie; Church, Alison] GlaxoSmithKline, Resp & Immunoinflammat, Res Triangle Pk, NC USA. [Crater, Glenn] Aerocrine, Clin Dev, Morrisville, NC USA. [Tabberer, Maggie] GlaxoSmithKline, Uxbridge, Middx, England. RP Decramer, M (reprint author), Univ Louvain, Div Resp, Univ Hosp, B-3000 Louvain, Belgium. EM marc.decramer@uzleuven.be OI Crater, Glenn/0000-0002-1159-1323 FU GlaxoSmithKline FX The work presented here, including the conduct of the study, data analysis, and data interpretation, was supported by GlaxoSmithKline. Editorial assistance in the preparation of the report was provided by David Griffiths (Fishawack Indicia, Knutsford, UK) and was funded by GlaxoSmithKline. NR 34 TC 88 Z9 90 U1 0 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-2600 J9 LANCET RESP MED JI Lancet Resp. Med. PD JUN PY 2014 VL 2 IS 6 BP 472 EP 486 DI 10.1016/S2213-2600(14)70065-7 PG 15 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AI2WA UT WOS:000336717900018 PM 24835833 ER PT J AU Gelernter, J Sherva, R Koesterer, R Almasy, L Zhao, H Kranzler, HR Farrer, L AF Gelernter, J. Sherva, R. Koesterer, R. Almasy, L. Zhao, H. Kranzler, H. R. Farrer, L. TI Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene SO MOLECULAR PSYCHIATRY LA English DT Article DE cocaine dependence; cocaine-induced paranoia; European-American and African-American populations; GWAS; population genetics ID POPULATION-BASED SAMPLE; INDUCED PSYCHOSIS; INDUCED PARANOIA; LINKAGE SCAN; ABUSE; ALCOHOLISM; TWINS AB We report a genome-wide association study (GWAS) for cocaine dependence (CD) in three sets of African-and European-American subjects (AAs and EAs, respectively) to identify pathways, genes and alleles important in CD risk. The discovery GWAS data set (n=5697 subjects) was genotyped using the Illumina OmniQuad microarray (8 90 000 analyzed single-nucleotide polymorphisms (SNPs)). Additional genotypes were imputed based on the 1000 Genomes reference panel. Top-ranked findings were evaluated by incorporating information from publicly available GWAS data from 4063 subjects. Then, the most significant GWAS SNPs were genotyped in 2549 independent subjects. We observed one genome-wide-significant (GWS) result: rs2629540 at the FAM53B (` family with sequence similarity 53, member B') locus. This was supported in both AAs and EAs; P-value (meta-analysis of all samples) 4.28 x 10(-8). The gene maps to the same chromosomal region as the maximum peak we observed in a previous linkage study. NCOR2 (nuclear receptor corepressor 2) SNP rs150954431 was associated with P = 1.19 x 10(-9) in the EA discovery sample. SNP rs2456778, which maps to CDK1 ('cyclin-dependent kinase 1'), was associated with cocaine-induced paranoia in AAs in the discovery sample only (P-4.68 x 10(-8)). This is the first study to identify risk variants for CD using GWAS. Our results implicate novel risk loci and provide insights into potential therapeutic and prevention strategies. C1 [Gelernter, J.] Yale Univ, Sch Med, Dept Psychiat, Div Human Genet, New Haven, CT USA. [Gelernter, J.] VA CT Healthcare Ctr, Dept Psychiat, West Haven, CT USA. [Gelernter, J.; Zhao, H.] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA. [Gelernter, J.] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT USA. [Sherva, R.; Koesterer, R.; Farrer, L.] Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA. [Almasy, L.] Texas Biomed Res Inst, Dept Genet, San Antonio, TX USA. [Zhao, H.] Yale Univ, Dept Biostat, Sch Publ Hlth, New Haven, CT USA. [Kranzler, H. R.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Kranzler, H. R.] Philadelphia VA Med Ctr, Dept Psychiat, Philadelphia, PA USA. [Farrer, L.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. [Farrer, L.] Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA. [Farrer, L.] Boston Univ, Sch Med, Dept Genet & Genom, Boston, MA 02118 USA. [Farrer, L.] Boston Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA 02215 USA. RP Gelernter, J (reprint author), Yale Univ, Sch Med, Dept Psychiat, Div Human Genet, VA CT 116A2,950 Campbell Ave, West Haven, CT 06516 USA. EM joel.gelernter@yale.edu OI Farrer, Lindsay/0000-0001-5533-4225 FU National Institutes of Health [N01-HG-65403, RC2 DA028909, R01 DA12690, R01 DA12849, R01 DA18432, R01 AA11330, R01 AA017535]; VA Connecticut and Philadelphia VA MIRECCs; Study of Addiction: Genetics and Environment (SAGE) was provided through the NIH Genes, Environment and Health Initiative [U01 HG004422]; Collaborative Study on the Genetics of Alcoholism (COGA) [U10 AA008401]; Collaborative Genetic Study of Nicotine Dependence (COGEND) [P01 CA089392]; Family Study of Cocaine Dependence (FSCD) [R01 DA013423]; Johns Hopkins University Center for Inherited Disease Research; NIH GEI [U01HG004438]; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; NIH contract 'High throughput genotyping for studying the genetic contributions to human disease' [HHSN268200782096C] FX We appreciate the work in recruitment and assessment provided at McLean Hospital by Roger Weiss at the Medical University of South Carolina by Kathleen Brady and Raymond Anton and at the University of Pennsylvania by David Oslin. Genotyping services for a part of our GWAS study were provided by the Center for Inherited Disease Research (CIDR) and Yale University (Center for Genome Analysis). CIDR is fully funded through a federal contract from the National Institutes of Health to The Johns Hopkins University (contract number N01-HG-65403). We are grateful to Ann Marie Lacobelle, Michelle Cucinelli, Christa Robinson and Greg Dalton-Kay for their excellent technical assistance, to the SSADDA interviewers, led by Yari Nunez and Michelle Slivinsky, who devoted substantial time and effort to phenotype the study sample and to John Farrell for database management assistance. This study was supported by National Institutes of Health Grants RC2 DA028909, R01 DA12690, R01 DA12849, R01 DA18432, R01 AA11330, R01 AA017535 and the VA Connecticut and Philadelphia VA MIRECCs. The publicly available data sets used for the analyses described in this manuscript were obtained from dbGaP at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs0 00092.v1.p1 through dbGaP accession number phs000092.v1.p. Funding support for the Study of Addiction: Genetics and Environment (SAGE) was provided through the NIH Genes, Environment and Health Initiative (GEI; U01 HG004422). SAGE is one of the genome-wide association studies funded as part of the Gene Environment Association Studies (GENEVA) under GEI. Assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the National Center for Biotechnology Information. Support for collection of data sets and samples was provided by the Collaborative Study on the Genetics of Alcoholism (COGA; U10 AA008401), the Collaborative Genetic Study of Nicotine Dependence (COGEND; P01 CA089392) and the Family Study of Cocaine Dependence (FSCD; R01 DA013423). Funding support for genotyping, which was performed at the Johns Hopkins University Center for Inherited Disease Research, was provided by the NIH GEI (U01HG004438), the National Institute on Alcohol Abuse and Alcoholism, the National Institute on Drug Abuse and the NIH contract 'High throughput genotyping for studying the genetic contributions to human disease' (HHSN268200782096C). NR 31 TC 29 Z9 29 U1 1 U2 11 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1359-4184 EI 1476-5578 J9 MOL PSYCHIATR JI Mol. Psychiatr. PD JUN PY 2014 VL 19 IS 6 BP 717 EP 723 DI 10.1038/mp.2013.99 PG 7 WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry GA AI2BZ UT WOS:000336663100014 PM 23958962 ER PT J AU Bludau, S Eickhoff, SB Mohlberg, H Caspers, S Laird, AR Fox, PT Schleicher, A Zilles, K Amunts, K AF Bludau, S. Eickhoff, S. B. Mohlberg, H. Caspers, S. Laird, A. R. Fox, P. T. Schleicher, A. Zilles, K. Amunts, K. TI Cytoarchitecture, probability maps and functions of the human frontal pole SO NEUROIMAGE LA English DT Article ID ROSTRAL PREFRONTAL CORTEX; HUMAN ORBITOFRONTAL CORTEX; HUMAN CEREBRAL-CORTEX; PRIMARY SOMATOSENSORY CORTEX; INTERINDIVIDUAL VARIABILITY; STEREOTAXIC SPACE; MICROSTRUCTURAL PARCELLATION; INTERSUBJECT VARIABILITY; QUANTITATIVE APPROACH; PROSPECTIVE MEMORY AB The frontal pole has more expanded than any other part in the human brain as compared to our ancestors. It plays an important role for specifically human behavior and cognitive abilities, e.g. action selection (Kovach et al., 2012). Evidence about divergent functions of its medial and lateral part has been provided, both in the healthy brain and in psychiatric disorders. The anatomical correlates of such functional segregation, however, are still unknown due to a lack of stereotaxic, microstructural maps obtained in a representative sample of brains. Here we show that the human frontopolar cortex consists of two cytoarchitectonically and functionally distinct areas: lateral frontopolar area 1 (Fp1) and medial frontopolar area 2 (Fp2). Based on observer-independent mapping in serial, cell-body stained sections of 10 brains, three-dimensional, probabilistic maps of areas Fp1 and Fp2 were created. They show, for each position of the reference space, the probability with which each area was found in a particular voxel. Applying these maps as seed regions for a meta-analysis revealed that Fp1 and Fp2 differentially contribute to functional networks: Fp1 was involved in cognition, working memory and perception, whereas Fp2 was part of brain networks underlying affective processing and social cognition. The present study thus disclosed cortical correlates of a functional segregation of the human frontopolar cortex. The probabilistic maps provide a sound anatomical basis for interpreting neuroimaging data in the living human brain, and open new perspectives for analyzing structure-function relationships in the prefrontal cortex. The new data will also serve as a starting point for further comparative studies between human and non-human primate brains. This allows finding similarities and differences in the organizational principles of the frontal lobe during evolution as neurobiological basis for our behavior and cognitive abilities. (C) 2013 Elsevier Inc. All rights reserved. C1 [Bludau, S.; Eickhoff, S. B.; Mohlberg, H.; Caspers, S.; Schleicher, A.; Zilles, K.; Amunts, K.] Res Ctr Julich, Inst Neurosci & Med INM 1, D-52425 Julich, Germany. [Eickhoff, S. B.] Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, D-40001 Dusseldorf, Germany. [Laird, A. R.; Fox, P. T.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Laird, A. R.; Fox, P. T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA. [Fox, P. T.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Zilles, K.] RVVTH Univ Aachen, Dept Psychiat Psychotherapy & Psychosomat, D-52074 Aachen, Germany. [Zilles, K.; Amunts, K.] JARA, Juelich Aachen Res Alliance, Julich, Germany. [Amunts, K.] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-40001 Dusseldorf, Germany. [Laird, A. R.] Florida Int Univ, Dept Phys, Miami, FL 33199 USA. RP Bludau, S (reprint author), Res Ctr Julich, Inst Neurosci & Med INM 1, D-52425 Julich, Germany. EM s.bludau@fz-juelich.de RI Zilles, Karl/J-9704-2013; Fox, Peter/B-4725-2010; Caspers, Svenja/H-9346-2013; Eickhoff, Simon/K-2061-2013; Amunts, Katrin/I-3470-2013 OI Zilles, Karl/0000-0001-9296-9959; Fox, Peter/0000-0002-0465-2028; Caspers, Svenja/0000-0001-5083-4669; Eickhoff, Simon/0000-0001-6363-2759; Bludau, Sebastian/0000-0001-6173-9050; Zilles, Karl/0000-0002-4705-4175; Amunts, Katrin/0000-0001-5828-0867 FU BMBF [01GW0612]; Helmholtz Alliance for Mental Health in an Aging Society (HeIMA); Helmholtz Alliance on Systems Biology (Human Brain Model) FX This study was supported by the BMBF (01GW0612, K.A.). Further funding was granted by the Helmholtz Alliance for Mental Health in an Aging Society (HeIMA; KA., K.Z.) and by the Helmholtz Alliance on Systems Biology (Human Brain Model; K.Z., S.B.E.). The authors thank Katerina Semendeferi for critical review of the manuscript and for helpful discussions. NR 104 TC 44 Z9 44 U1 4 U2 20 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD JUN PY 2014 VL 93 SI SI BP 260 EP 275 DI 10.1016/j.neuroimage.2013.05.052 PN 2 PG 16 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA AI0RG UT WOS:000336556500012 PM 23702412 ER PT J AU Skaperdas, E Tuepker, A Nicolaidis, C Robb, JK Kansagara, D Hickam, DH AF Skaperdas, Eleni Tuepker, Anais Nicolaidis, Christina Robb, Jessica K. Kansagara, Devan Hickam, David H. TI Congestive heart failure self-management among US veterans: The role of personal and professional advocates SO PATIENT EDUCATION AND COUNSELING LA English DT Article DE Primary care redesign; Self-management; Qualitative research; Heart failure; Veterans; US ID CONTROLLED-TRIAL; CARE MANAGEMENT; EXPERIENCES; ADHERENCE; PATIENT; PROGRAM; RISK AB Objective: Understand patients' experiences with primary care services for congestive heart failure (CHF) and explore the relationship between health services and self-management. Methods: We conducted semi-structured interviews with thirty-nine patients with CHF receiving care at one Veterans Affairs Medical Center (VA). We analyzed data using thematic content analysis. Results: Participants acknowledged the importance of ongoing engagement in the plan of care for CHF. They attributed success in this effort to be greatly influenced by personal advocates. The advocates included both members of the healthcare team with whom they had a continuity relationship and friends or family members who assisted on a daily basis. Participants also identified psychological symptoms as a major barrier to carrying out self-care. Conclusion: Patients identify relationships with health care workers, help from family and friends, and mental health problems as major influences on the ability to manage their CHF. Practice implications: Efforts to optimize CHF self-management should attend to health system and psychosocial barriers to care. Published by Elsevier Ireland Ltd. C1 [Skaperdas, Eleni; Tuepker, Anais; Robb, Jessica K.; Kansagara, Devan; Hickam, David H.] Vet Hlth Adm, Portland VA Med Ctr Hlth Serv Res & Dev, VISN PACT Demonstrat Lab 20, Portland, OR USA. [Tuepker, Anais; Kansagara, Devan] Oregon Hlth & Sci Univ, Dept Med, Div Gen Internal Med & Geriatr, Portland, OR 97201 USA. [Nicolaidis, Christina] Portland State Univ, Sch Social Work, Portland, OR 97207 USA. [Nicolaidis, Christina] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97201 USA. [Hickam, David H.] Patient Centered Outcomes Res Inst, Washington, DC USA. RP Skaperdas, E (reprint author), Portland VA Med Ctr, Mailcode R&D63,POB 1034, Portland, OR 97207 USA. EM eleni.skaperdas@va.gov FU VA Office of Patient Care FX We thank the Veterans, their family members, and close friends for sharing their experiences, and gratefully acknowledge the contribution of all members of the VISN 20 PACT Demonstration Lab. Funding for the PACT Demonstration Laboratory initiative is provided by the VA Office of Patient Care. NR 28 TC 3 Z9 3 U1 1 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0738-3991 J9 PATIENT EDUC COUNS JI Patient Educ. Couns. PD JUN PY 2014 VL 95 IS 3 BP 371 EP 377 DI 10.1016/j.pec.2014.03.002 PG 7 WC Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary SC Public, Environmental & Occupational Health; Social Sciences - Other Topics GA AI3QD UT WOS:000336776100011 PM 24666772 ER PT J AU Koenig, CJ Maguen, S Monroy, JD Mayott, L Seal, KH AF Koenig, Christopher J. Maguen, Shira Monroy, Jose D. Mayott, Lindsay Seal, Karen H. TI Facilitating culture-centered communication between health care providers and veterans transitioning from military deployment to civilian life SO PATIENT EDUCATION AND COUNSELING LA English DT Article DE Patient-centered care; Health communication; Culture; Post-deployment health; Readjustment experience; Military veterans; USA ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; AFGHANISTAN VETERANS; MENTAL-HEALTH; DISCOURSE ANALYSIS; COMBAT VETERANS; IRAQ; HOME; BARRIERS; FAMILY AB Objective: To describe returning veterans' transition experience from military to civilian life and to educate health care providers about culture-centered communication that promotes readjustment to civilian life. Methods: Qualitative, in-depth, semi-structured interviews with 17 male and 14 female Iraq and Afghanistan veterans were audio recorded, transcribed verbatim, and analyzed using Grounded Practical Theory. Results: Veterans described disorientation when returning to civilian life after deployment. Veterans' experiences resulted from an underlying tension between military and civilian identities consistent with reverse culture shock. Participants described challenges and strategies for managing readjustment stress across three domains: intrapersonal, professional/educational, and interpersonal. Conclusions: To provide patient-centered care to returning Iraq and Afghanistan veterans, health care providers must be attuned to medical, psychological, and social challenges of the readjustment experience, including reverse culture shock. Cultufe-centered communication may help veterans integrate positive aspects of military and civilian identities, which may promote full reintegration into civilian life. Practice implications: Health care providers may promote culture-centered interactions by asking veterans to reflect about their readjustment experiences. By actively eliciting challenges and helping veterans' to identify possible solutions, health care providers may help veterans integrate military and civilian identities through an increased therapeutic alliance and social support throughout the readjustment process. Published by Elsevier Ireland Ltd. C1 [Koenig, Christopher J.; Maguen, Shira; Monroy, Jose D.; Mayott, Lindsay; Seal, Karen H.] San Francisco Vet Adm Med Ctr, San Francisco, CA 94121 USA. [Koenig, Christopher J.] Univ Calif San Francisco, Philip R Lee Inst Hlth Policy Studies, San Francisco, CA 94143 USA. [Maguen, Shira; Seal, Karen H.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. [Koenig, Christopher J.; Mayott, Lindsay; Seal, Karen H.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Monroy, Jose D.] San Francisco State Univ, Dept Psychol, San Francisco, CA 94132 USA. RP Koenig, CJ (reprint author), San Francisco Vet Adm Med Ctr, Dept Med, 4150 Clement St,111-A1, San Francisco, CA 94121 USA. EM Christopher.Koenig@va.gov OI Koenig, Christopher J./0000-0003-0884-4120 FU Department of Defense [W81XWH-08-2-0106] FX Department of Defense award W81XWH-08-2-0106 funded this study. The funders had no role in the design, data analysis, writing or approval of the manuscript. NR 66 TC 5 Z9 5 U1 6 U2 32 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0738-3991 J9 PATIENT EDUC COUNS JI Patient Educ. Couns. PD JUN PY 2014 VL 95 IS 3 BP 414 EP 420 DI 10.1016/j.pec.2014.03.016 PG 7 WC Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary SC Public, Environmental & Occupational Health; Social Sciences - Other Topics GA AI3QD UT WOS:000336776100017 PM 24742536 ER PT J AU Clarke, TK Crist, RC Ang, A Ambrose-Lanci, LM Lohoff, FW Saxon, AJ Ling, W Hillhouse, MP Bruce, RD Woody, G Berrettini, WH AF Clarke, T-K Crist, R. C. Ang, A. Ambrose-Lanci, L. M. Lohoff, F. W. Saxon, A. J. Ling, W. Hillhouse, M. P. Bruce, R. D. Woody, G. Berrettini, W. H. TI Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females SO PHARMACOGENOMICS JOURNAL LA English DT Article DE buprenorphine; females; methadone; opioids; OPRD1; pharmacogenetics ID METHADONE-MAINTENANCE TREATMENT; RECEPTOR GENE; POSTOPERATIVE PAIN; GENDER-DIFFERENCES; OPIATE DEPENDENCE; RANDOMIZED-TRIAL; DRUG-DEPENDENCE; ABUSE TREATMENT; SEX-DIFFERENCES; ANALGESIA AB Two commonly prescribed treatments for opioid addiction are methadone and buprenorphine. Although these drugs show some efficacy in treating opioid dependence, treatment response varies among individuals. It is likely that genetic factors have a role in determining treatment outcome. This study analyses the pharmacogenetic association of six polymorphisms in OPRD1, the gene encoding the delta-opioid receptor, on treatment outcome in 582 opioid addicted European Americans randomized to either methadone or buprenorphine/naloxone (Suboxone) over the course of a 24-week open-label clinical trial. Treatment outcome was assessed as the number of missed or opioid-positive urine drug screens over the 24 weeks. In the total sample, no single-nucleotide polymorphisms (SNPs) in OPRD1 were significantly associated with treatment outcome in either treatment arm. However, sex-specific analyses revealed two intronic SNPs (rs581111 and rs529520) that predicted treatment outcome in females treated with buprenorphine. Females with the AA or AG genotypes at rs581111 had significantly worse outcomes than those with the GG genotype when treated with buprenorphine (P=0.03, relative risk (RR) = 1.67, 95% confidence interval (CI) 1.06-2.1). For rs529520, females with the AA genotype had a significantly worse outcome than those with the CC genotype when (P=0.006, RR =2.15, 95% CI 1.3-2.29). No significant associations were detected in males. These findings suggest that rs581111 and rs52920 may be usefulwhen considering treatment options for female opioid addicts, however, confirmation in an independent sample is warranted. C1 [Clarke, T-K; Crist, R. C.; Ambrose-Lanci, L. M.; Lohoff, F. W.; Berrettini, W. H.] Univ Penn, Sch Med, Translat Res Labs, Dept Psychiat,Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA. [Ang, A.; Ling, W.; Hillhouse, M. P.] Univ Calif Los Angeles, Integrated Subst Abuse Programs, Los Angeles, CA USA. [Saxon, A. J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. [Bruce, R. D.] Yale Univ, Sch Med, New Haven, CT USA. [Woody, G.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Woody, G.] Treatment Res Inst, Philadelphia, PA USA. RP Clarke, TK (reprint author), Univ Penn, Sch Med, Translat Res Labs, Dept Psychiat,Ctr Neurobiol & Behav, 125 South 31st St,Room 2109, Philadelphia, PA 19104 USA. EM ctoni@mail.med.upenn.edu RI Lohoff, Falk/M-7951-2016 OI Clarke, Toni-Kim/0000-0002-7745-6351 FU National Institute on Drug Abuse through the Clinical Trials Network (CTN); Pacific Northwest Node [U10 DA01714]; Oregon Hawaii Node [U10 DA013036]; California/Arizona Node [U10 DA015815]; New England Node [U10 DA13038]; Delaware Valley Node [U10 DA13043]; Pacific Region Node [U10 DA13045]; New York Node [U10 DA013046]; Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania [T32MH014654]; NIDA [P20DA025995, P60DA05186]; Veterans Administration Mental Illness Research Education; Clinical Center MIRECC FX Main START study funding came from the National Institute on Drug Abuse through the Clinical Trials Network (CTN) through a series of grants provided to each participating node: the Pacific Northwest Node (U10 DA01714), the Oregon Hawaii Node (U10 DA013036), the California/Arizona Node (U10 DA015815), the New England Node (U10 DA13038), the Delaware Valley Node (U10 DA13043), the Pacific Region Node (U10 DA13045) and the New York Node (U10 DA013046). Dr Berrettini was also supported by the Delaware Valley Node (U10 DA13043). This work was supported by the Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Training Program in Neuropsychopharmacology (T32MH014654, PI: I Lucki), NIDA grant P20DA025995 (PI: W Berrettini), the Veterans Administration Mental Illness Research Education and Clinical Center MIRECC) at the Philadelphia VAMC (David Oslin, MD, PI) and NIDA grant P60DA05186 (PI: Charles O'Brien). NR 51 TC 8 Z9 9 U1 1 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1470-269X EI 1473-1150 J9 PHARMACOGENOMICS J JI Pharmacogenomics J. PD JUN PY 2014 VL 14 IS 3 BP 303 EP 308 DI 10.1038/tpj.2013.30 PG 6 WC Genetics & Heredity; Pharmacology & Pharmacy SC Genetics & Heredity; Pharmacology & Pharmacy GA AI0SK UT WOS:000336560000015 PM 24126707 ER PT J AU Reynolds, CF Thomas, SB Morse, JQ Anderson, SJ Albert, S Dew, MA Begley, A Karp, JF Gildengers, A Butters, MA Stack, JA Kasckow, J Miller, MD Quinn, SC AF Reynolds, Charles F., III Thomas, Stephen B. Morse, Jennifer Q. Anderson, Stewart J. Albert, Steven Dew, Mary Amanda Begley, Amy Karp, Jordan F. Gildengers, Ariel Butters, Meryl A. Stack, Jacqueline A. Kasckow, John Miller, Mark D. Quinn, Sandra C. TI Early Intervention to Preempt Major Depression Among Older Black and White Adults SO PSYCHIATRIC SERVICES LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; LATE-LIFE DEPRESSION; PROBLEM-SOLVING THERAPY; PRIMARY-CARE PATIENTS; PREVENTING DEPRESSION; GERIATRIC DEPRESSION; RISK-FACTORS; METAANALYSIS; INVENTORY; SYMPTOMS AB Objective: The study objective was to assess the efficacy of problem-solving therapy for primary care (PST-PC) for preventing episodes of major depression and mitigating depressive symptoms of older black and white adults. The comparison group received dietary coaching. Methods: A total of 247 participants (90 blacks, 154 whites, and three Asians) with subsyndromal depressive symptoms were recruited into a randomized depression prevention trial that compared effects of individually delivered PST-PC and dietary coaching on time to major depressive episode and level of depressive symptoms (Beck Depression Inventory) over two years. Cumulative intervention time averaged 5.5-6.0 hours in each study arm. Results: The two groups did not differ significantly in time to major depressive episodes, and incidence of such episodes was low (blacks, N=8, 9%; whites, N=13, 8%), compared with published rates of 20%-25% over one year among persons with subsyndromal symptoms and receiving care as usual. Participants also showed a mean decrease of 4 points in depressive symptoms, sustained over two years. Despite greater burden of depression risk factors among blacks, no significant differences from whites were found in the primary outcome. Conclusions: Both PST-PC and dietary coaching are potentially effective in protecting older black and white adults with subsyndromal depressive symptoms from developing episodes of major depression over two years. Absent a control for concurrent usual care, this conclusion is preliminary. If confirmed, both interventions hold promise as scalable, safe, nonstigmatizing interventions for delaying or preventing episodes of major depression in the nation's increasingly diverse older population. C1 [Reynolds, Charles F., III; Morse, Jennifer Q.; Dew, Mary Amanda; Begley, Amy; Karp, Jordan F.; Gildengers, Ariel; Butters, Meryl A.; Stack, Jacqueline A.; Kasckow, John; Miller, Mark D.] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA. [Kasckow, John] Vet Affairs Pittsburgh Hlth Care Syst, Dept Behav Hlth, Pittsburgh, PA USA. [Thomas, Stephen B.; Quinn, Sandra C.] Univ Maryland, Ctr Hlth Equ, College Pk, MD 20742 USA. [Anderson, Stewart J.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA. [Albert, Steven] Univ Pittsburgh, Dept Behav & Community Hlth Sci, Pittsburgh, PA USA. RP Reynolds, CF (reprint author), Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA. EM reynoldscf@upmc.edu OI Anderson, Stewart/0000-0001-8948-0650; Albert, Steven/0000-0001-6786-9956 FU National Institute of Mental Health [P60 MD000207, P30 MH090333, UL1RR024153, UL1TR000005]; National Institutes of Health; University of Pittsburgh Medical Center Endowment in Geriatric Psychiatry; Commonwealth of Pennsylvania; Bristol-Myers Squibb; Forest; Pfizer; Lilly; Robert Bosch Health Care, Inc. FX This work was supported by grants P60 MD000207, P30 MH090333, UL1RR024153, and UL1TR000005 from the National Institute of Mental Health and National Institutes of Health, by the University of Pittsburgh Medical Center Endowment in Geriatric Psychiatry, and by the Commonwealth of Pennsylvania. This work is registered on ClinicalTrials.gov as NCT00326677.; Dr. Reynolds reports receiving pharmaceutical support for National Institutes of Health sponsored research studies from Bristol-Myers Squibb, Forest, Pfizer, and Lilly. He is the co-inventor of Psychometric Analysis of the Pittsburgh Sleep Quality Index (licensed intellectual property PRO10050447). Dr. Karp reports receipt of medication supplies from Pfizer and Reckitt Benckiser for investigator-initiated studies. Dr. Butters has received remuneration from GlaxoSmithKline for performing neuropsychological services. Dr. Kasckow has received assistance from Robert Bosch Health Care, Inc., for software-related costs for a research project. The other authors report no competing interests. NR 37 TC 14 Z9 14 U1 1 U2 5 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 EI 1557-9700 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD JUN PY 2014 VL 65 IS 6 BP 765 EP 773 DI 10.1176/appi.ps.201300216 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA AI3RJ UT WOS:000336779300009 PM 24632760 ER PT J AU El-Serag, HB Sweet, S Winchester, CC Dent, J AF El-Serag, Hashem B. Sweet, Stephen Winchester, Christopher C. Dent, John TI Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review SO GUT LA English DT Article ID IRRITABLE-BOWEL-SYNDROME; QUALITY-OF-LIFE; RISK-FACTORS; CLINICAL SPECTRUM; GENERAL-POPULATION; BARRETTS-ESOPHAGUS; ADULT-POPULATION; PRIMARY-CARE; PREVALENCE; SYMPTOMS AB Objective To update the findings of the 2005 systematic review of population-based studies assessing the epidemiology of gastro-oesophageal reflux disease (GERD). Design PubMed and Embase were screened for new references using the original search strings. Studies were required to be population-based, to include >= 200 individuals, to have response rates >= 50% and recall periods < 12 months. GERD was defined as heartburn and/or regurgitation on at least 1 day a week, or according to the Montreal definition, or diagnosed by a clinician. Temporal and geographic trends in disease prevalence were examined using a Poisson regression model. Results 16 studies of GERD epidemiology published since the original review were found to be suitable for inclusion (15 reporting prevalence and one reporting incidence), and were added to the 13 prevalence and two incidence studies found previously. The range of GERD prevalence estimates was 18.1%-27.8% in North America, 8.8%-25.9% in Europe, 2.5%-7.8% in East Asia, 8.7%-33.1% in the Middle East, 11.6% in Australia and 23.0% in South America. Incidence per 1000 person-years was approximately 5 in the overall UK and US populations, and 0.84 in paediatric patients aged 117 years in the UK. Evidence suggests an increase in GERD prevalence since 1995 (p<0.0001), particularly in North America and East Asia. Conclusions GERD is prevalent worldwide, and disease burden may be increasing. Prevalence estimates show considerable geographic variation, but only East Asia shows estimates consistently lower than 10%. C1 [El-Serag, Hashem B.] Houston Vet Affairs Med Ctr 152, Sect Gastroenterol & Hepatol, Houston, TX USA. [Sweet, Stephen; Winchester, Christopher C.] Oxford PharmaGenesis, Res Evaluat Unit, Oxford, England. [Winchester, Christopher C.] Univ Aberdeen, Ctr Acad Primary Care, Aberdeen, Scotland. [Dent, John] Royal Adelaide Hosp, Dept Gastroenterol Hepatol & Gen Med, Adelaide, SA 5000, Australia. RP El-Serag, HB (reprint author), Houston VA Med Ctr, Sect Gastroenterol & Hepatol, 2002 Holcombe Blvd 152, Houston, TX 77030 USA. EM hasheme@bcm.edu OI Winchester, Christopher/0000-0003-3267-3990 FU Texas Digestive Disease Center [NIH DK58338, NIDDK K24-04-107]; Houston VA Health Services R&D Center of Excellence [HFP90-020]; AstraZeneca R&D, Molndal, Sweden FX This work was supported in part by Texas Digestive Disease Center grants NIH DK58338 and NIDDK K24-04-107 to Dr El-Serag and by the Houston VA Health Services R&D Center of Excellence (HFP90-020). The views expressed in this article are those of the author(s) and do not necessarily represent the views of the Department of Veterans Affairs. Stephen Sweet and Christopher C Winchester are employees of Oxford PharmaGenesis, which received funding from AstraZeneca R&D, Molndal, Sweden for its role in the preparation of this systematic review. NR 49 TC 157 Z9 172 U1 1 U2 22 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0017-5749 EI 1468-3288 J9 GUT JI Gut PD JUN PY 2014 VL 63 IS 6 BP 871 EP 880 DI 10.1136/gutjnl-2012-304269 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AG4AB UT WOS:000335360000006 PM 23853213 ER PT J AU Martin, JT Milby, AH Chiaro, JA Kim, DH Hebela, NM Smith, LJ Elliott, DM Mauck, RL AF Martin, John T. Milby, Andrew H. Chiaro, Joseph A. Kim, Dong Hwa Hebela, Nader M. Smith, Lachlan J. Elliott, Dawn M. Mauck, Robert L. TI Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model SO ACTA BIOMATERIALIA LA English DT Article DE Intervertebral disc; Tissue engineering; Electrospinning; Surgical model; External fixation ID HUMAN LUMBAR DISC; LOW-BACK-PAIN; ANNULUS FIBROSUS; BIOMECHANICAL FUNCTION; DYNAMIC COMPRESSION; LOADING IMPROVES; NUCLEUS PULPOSUS; ANULUS FIBROSUS; NEEDLE PUNCTURE; SCAFFOLDS AB Intervertebral disc degeneration has been implicated in the etiology of low back pain; however, the current surgical strategies for treating symptomatic disc disease are limited. A variety of materials have been developed to replace disc components, including the nucleus pulposus (NP), the annulus fibrosus (AF) and their combination into disc-like engineered constructs. We have previously shown that layers of electrospun poly(epsilon-caprolactone) scaffold, mimicking the hierarchical organization of the native AF, can achieve functional parity with native tissue. Likewise, we have combined these structures with cell-seeded hydrogels (as an NP replacement) to form disc-like angle-ply structures (DAPS). The objective of this study was to develop a model for the evaluation of DAPS in vivo. Through a series of studies, we developed a surgical approach to replace the rat caudal disc with an acellular DAPS and then stabilized the motion segment via external fixation. We then optimized cell infiltration into DAPS by including sacrificial poly(ethylene oxide) layers interspersed throughout the angle-ply structure. Our findings illustrate that DAPS are stable in the caudal spine, are infiltrated by cells from the pen-implant space and that infiltration is expedited by providing additional routes for cell migration. These findings establish a new in vivo platform in which to evaluate and optimize the design of functional disc replacements. (C) 2014 Acts Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Martin, John T.; Milby, Andrew H.; Chiaro, Joseph A.; Kim, Dong Hwa; Hebela, Nader M.; Smith, Lachlan J.; Mauck, Robert L.] Univ Penn, Dept Orthopaed Surg, McKay Orthopaed Res Lab, Philadelphia, PA 19104 USA. [Martin, John T.; Mauck, Robert L.] Univ Penn, Dept Mech Engn & Appl Mech, Philadelphia, PA 19104 USA. [Elliott, Dawn M.] Univ Delaware, Dept Biomed Engn, Newark, DE 19716 USA. [Mauck, Robert L.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Martin, John T.; Milby, Andrew H.; Chiaro, Joseph A.; Hebela, Nader M.; Smith, Lachlan J.; Mauck, Robert L.] Philadelphia VA Med Ctr, Translat Musculoskeletal Res Ctr, Philadelphia, PA 19104 USA. [Smith, Lachlan J.] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA. RP Mauck, RL (reprint author), Univ Penn, Dept Orthopaed Surg, McKay Orthopaed Res Lab, 36th St & Hamilton Walk,424 Stemmler Hall, Philadelphia, PA 19104 USA. EM lemauck@mail.med.upenn.edu FU Department of Defense [OR090090]; Department of Veterans Affairs [I01RX000211] FX We would like to thank the exceptional staff of the Philadelphia VA Medical Center Animal Research Facility: Debra Pawlowski, Jeffrey House and Pierina Deritis. In addition we would like to thank Deborah Gorth and Feini Qu (animal procedures), Alexei Adan (DAPS fabrication and histology), Subash Poudel (DAPS geometry and mechanical property measurements), Sophia Stylianos (fabrication of surgical equipment) and Dr. Thomas Schaer (sterilization facilities). This work was funded by the Department of Defense (Grant #OR090090) and the Department of Veterans Affairs (Grant # I01RX000211). NR 49 TC 18 Z9 21 U1 5 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 EI 1878-7568 J9 ACTA BIOMATER JI Acta Biomater. PD JUN PY 2014 VL 10 IS 6 BP 2473 EP 2481 DI 10.1016/j.actbio.2014.02.024 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AH7WK UT WOS:000336345900012 PM 24560621 ER PT J AU Scherzer, R Gandhi, M Estrella, MM Tien, PC Deeks, SG Grunfeld, C Peralta, CA Shlipak, MG AF Scherzer, Rebecca Gandhi, Monica Estrella, Michelle M. Tien, Phyllis C. Deeks, Steven G. Grunfeld, Carl Peralta, Carmen A. Shlipak, Michael G. TI A chronic kidney disease risk score to determine tenofovir safety in a prospective cohort of HIV-positive male veterans SO AIDS LA English DT Article DE chronic kidney disease; HIV; risk score; tenofovir ID INFECTED PATIENTS; RANDOMIZED-TRIAL; RENAL-FAILURE; CYSTATIN-C; THERAPY; INDIVIDUALS; ALBUMINURIA; ASSOCIATION; DYSFUNCTION; EXPOSURE AB Objective:Tenofovir disoproxil fumarate is a widely used antiretroviral for HIV infection that has been associated with an increased risk of chronic kidney disease (CKD). Our objective was to derive a scoring system to predict 5-year risk of developing CKD in HIV-infected individuals and to estimate difference in risk associated with tenofovir use.Design:We evaluated time to first occurrence of CKD (estimated glomerular filtration rate <60ml/min per 1.73m(2)) in 21590 HIV-infected men from the Veterans Health Administration initiating antiretroviral therapy from 1997 to 2010.Methods:We developed a point-based score using multivariable Cox regression models. Median follow-up was 6.3 years, during which 2059 CKD events occurred.Results:Dominant contributors to the CKD risk score were traditional kidney risk factors (age, glucose, SBP, hypertension, triglycerides, proteinuria); CD4(+) cell count was also a component, but not HIV RNA. The overall 5-year event rate was 7.7% in tenofovir users and 3.8% in nonusers [overall adjusted hazard ratio 2.0, 95% confidence interval (CI) 1.8-2.2]. There was a progressive increase in 5-year CKD risk, ranging from less than 1% (zero points) to 16% (9 points) in nonusers of tenofovir, and from 1.4 to 21.4% among tenofovir users. The estimated number-needed-to-harm (NNH) for tenofovir use ranged from 108 for those with zero points to 20 for persons with at least nine points. Among tenofovir users with at least 1 year exposure, NNH ranged from 68 (zero points) to five (9 points).Conclusion:The CKD risk score can be used to predict an HIV-infected individual's absolute risk of developing CKD over 5 years and may facilitate clinical decision-making around tenofovir use. C1 [Scherzer, Rebecca; Gandhi, Monica; Tien, Phyllis C.; Deeks, Steven G.; Grunfeld, Carl; Peralta, Carmen A.; Shlipak, Michael G.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Scherzer, Rebecca; Tien, Phyllis C.; Grunfeld, Carl; Peralta, Carmen A.; Shlipak, Michael G.] San Francisco VA Med Ctr, San Francisco, CA USA. [Gandhi, Monica; Deeks, Steven G.] San Francisco Gen Hosp, Posit Hlth Program, San Francisco, CA 94110 USA. [Estrella, Michelle M.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Shlipak, MG (reprint author), Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. EM michael.shlipak@ucsf.edu FU National Institutes of Health [K23DK080645-01A1, 1R03AG034871-01, K24AI069994, R01 DK066488-01, RO1 AI098472]; National Center for Research Resources [KL2 RR024130]; American Heart Association Established Investigator Award; VA Public Health Strategic Healthcare Group; Gilead; Merck; Bristol-Myers Squibb; Abbott; Gilead Sciences; EMD Serono; Theratechnologies FX This work was supported by the National Institutes of Health [K23DK080645-01A1 (A. I. C.), 1R03AG034871-01 (A.I.C./M.G.S.), K24AI069994, R01 DK066488-01 (M.G.S./A.I.C.), RO1 AI098472 (M. G.)], the National Center for Research Resources [KL2 RR024130], the American Heart Association Established Investigator Award (M.G.S.) and the VA Public Health Strategic Healthcare Group, which were administered by the Northern California Institute for Research and Education, and with resources of the Veterans Affairs Medical Center, San Francisco, California. These funding sources had no involvement in the design or execution of this study. S. G. D. received grant support from Gilead and Merck, and honorarium for ad hoc consulting from Gilead and GlaxoSmithKline. C.G. has received prior research funding and/or honorarium from Merck, Bristol-Myers Squibb, Abbott, Gilead Sciences, EMD Serono and Theratechnologies. NR 30 TC 9 Z9 9 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JUN 1 PY 2014 VL 28 IS 9 BP 1289 EP 1295 DI 10.1097/QAD.0000000000000258 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AH2SX UT WOS:000335972500006 PM 24922479 ER PT J AU Katz, IR AF Katz, Ira R. TI Mental Health Needs of Older Veterans SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Editorial Material ID NATIONAL-HEALTH; RESILIENCE C1 Philadelphia VA Med Ctr, Philadelphia, PA 19104 USA. RP Katz, IR (reprint author), Philadelphia VA Med Ctr, Univ & Woodland Aves, Philadelphia, PA 19104 USA. EM Ira.Katz2@va.gov NR 13 TC 1 Z9 1 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD JUN PY 2014 VL 22 IS 6 BP 527 EP 530 DI 10.1016/j.jagp.2014.01.014 PG 4 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA AH4HG UT WOS:000336087400001 PM 24821286 ER PT J AU Yeager, DE Magruder, KM AF Yeager, Derik E. Magruder, Kathryn M. TI PTSD Checklist Scoring Rules for Elderly Veterans Affairs Outpatients SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Article DE PTSD; screening; elderly ID POSTTRAUMATIC-STRESS-DISORDER; PREVALENCE AB Objective: To assess the diagnostic performance of the PTSDChecklist (PCL) for three age groups (<50, 50-64, and >= 65 years). Methods: The PCL was compared with the Clinician Administered PTSD Scale, a gold standard for the diagnosis of post-traumatic stress disorder. Receiver operating characteristic curves and the corresponding area under the receiver operating characteristic curve (AUC) and measures of sensitivity and specificity were used to assess the performance of and to determine optimal cutscores for the PCL across the three groups. Analyses were based on 858 randomly selected primary care patients who participated in a study conducted at four Veterans Administration medical centers. Results: AUCs were high for all three age groups (87.55%-88.26%), and there were no significant differences in AUCs across age groups chi(2). Optimal cutscores, however, varied considerably: 24 for the oldest group, 34 for the middle group, and 43 for the youngest group. Conclusion: Recommend use of lower PCL cutscore for older Veterans Administration primary care patients. C1 [Yeager, Derik E.; Magruder, Kathryn M.] Ralph H Johnson Vet Affairs Med Ctr, Mental Hlth Serv, Charleston, SC USA. [Yeager, Derik E.; Magruder, Kathryn M.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA. RP Yeager, DE (reprint author), Med Univ S Carolina, Dept Psychiat & Behav Sci, 67 President St, Charleston, SC 29425 USA. EM yeagerde@musc.edu FU Department of Veterans Affairs; Veterans Health Administration; Office of Research and Development; Health Services Research and Development [VCR 99-010-2]; National Center for Research Resources [UL1TR000062] FX Supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and Health Services Research and Development (VCR 99-010-2). The views expressed in this report are those of the authors and do not necessarily reflect the position or policy of the Department of Veteran Affairs or the U.S. government.; Also supported by award number UL1TR000062 from the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health. NR 13 TC 4 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD JUN PY 2014 VL 22 IS 6 BP 545 EP 550 DI 10.1016/j.jagp.2013.03.009 PG 6 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA AH4HG UT WOS:000336087400004 PM 24041524 ER PT J AU Covinsky, KE Cenzer, IS Yaffe, K O'Brien, S Blazer, DG AF Covinsky, Kenneth E. Cenzer, Irena Stijacic Yaffe, Kristine O'Brien, Sarah Blazer, Dan G. TI Dysphoria and Anhedonia as Risk Factors for Disability or Death in Older Persons: Implications for the Assessment of Geriatric Depression SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Article DE Depression; anhedonia; activities of daily living; quality of life; health status ID SUBTHRESHOLD DEPRESSION; FUNCTIONAL LIMITATIONS; VASCULAR DEPRESSION; COMMUNITY SAMPLE; ELDERLY PERSONS; LATER-LIFE; SYMPTOMS; ADULTS; MORTALITY; DIRECTIONS AB Objectives: Either dysphoria (sadness) or anhedonia (loss of interest in usually pleasurable activities) is required for a diagnosis of major depression. Although major depression is a known risk factor for disability in older persons, few studies have examined the relationship between the two core symptoms of major depression and disability or mortality. Our objective was to examine the relationship between these two core symptoms and time to disability or death. Methods: In a longitudinal cohort study, we used the nationally representative Health and Retirement Study to examine this relationship in 11,353 persons older than 62 years (mean: 73 years) followed for up to 13 years. Dysphoria and anhedonia were assessed with the Short Form Composite International Diagnostic Interview. Our outcome measure was time to either death or increased disability, defined as the new need for help in a basic activity of daily living. We adjusted for a validated disability risk index and other confounders. Results: Compared with subjects without either dysphoria or anhedonia, the risk for disability or death was not elevated in elders with dysphoria without anhedonia (adjusted hazard ratio [HR]: 1.11; 95% confidence interval [CI]: 0.91-1.36). The risk was elevated in those with anhedonia without dysphoria (HR: 1.30; 95% CI: 1.06-1.60) and those with both anhedonia and dysphoria (HR: 1.28; 95% CI: 1.13-1.46). Conclusion: Our results highlight the need for clinicians to learn whether patients have lost interest in usually pleasurable activities, even if they deny sadness. C1 [Covinsky, Kenneth E.; Cenzer, Irena Stijacic; O'Brien, Sarah] Univ Calif San Francisco, Dept Med, San Francisco, CA 94121 USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94121 USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94121 USA. [Covinsky, Kenneth E.; Cenzer, Irena Stijacic; Yaffe, Kristine; O'Brien, Sarah] San Francisco VA Med Ctr, San Francisco, CA USA. [Blazer, Dan G.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA. RP Covinsky, KE (reprint author), Univ Calif San Francisco, San Francisco VA Med Ctr 181G, 4150 Clement, San Francisco, CA 94121 USA. EM ken.covinsky@ucsf.edu FU National Institute on Aging [R01AG028481, K24AG029812] FX Supported by grants R01AG028481 and K24AG029812 from the National Institute on Aging. The Health and Retirement Study is funded by the National Institute on Aging. NR 34 TC 9 Z9 9 U1 5 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD JUN PY 2014 VL 22 IS 6 BP 606 EP 613 DI 10.1016/j.jagp.2012.12.001 PG 8 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA AH4HG UT WOS:000336087400011 PM 23602308 ER PT J AU Kim, J Won, JS Singh, AK Sharma, AK Singh, I AF Kim, Jinsu Won, Je-Seong Singh, Avtar K. Sharma, Anand K. Singh, Inderjit TI STAT3 Regulation by S-Nitrosylation: Implication for Inflammatory Disease SO ANTIOXIDANTS & REDOX SIGNALING LA English DT Article ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; MEDIATED RECEPTOR-BINDING; EPIDERMAL-GROWTH-FACTOR; BRAIN MICROGLIAL CELLS; NITRIC-OXIDE; JAK-STAT; TYROSINE PHOSPHORYLATION; SERINE PHOSPHORYLATION; NITROSO-GLUTATHIONE AB Aims: S-nitrosylation and S-glutathionylation, redox-based modifications of protein thiols, are recently emerging as important signaling mechanisms. In this study, we assessed S-nitrosylation-based regulation of Janus-activated kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway that plays critical roles in immune/inflammatory responses and tumorigenesis. Results: Our studies show that STAT3 in stimulated microglia underwent two distinct redox-dependent modifications, S-nitrosylation and S-glutathionylation. STAT3 S-nitrosylation was associated with inducible nitric oxide synthase (iNOS)-produced nitric oxide (NO) and S-nitrosoglutathione (GSNO), whereas S-glutathionylation of STAT3 was associated with cellular oxidative stress. NO produced by iNOS or treatment of microglia with exogenous GSNO inhibited STAT3 activation via inhibiting STAT3 phosphorylation (Tyr(705)). Consequently, the interleukin-6 (IL-6)-induced microglial proliferation and associated gene expressions were also reduced. In cell-free kinase assay using purified JAK2 and STAT3, STAT3 phosphorylation was inhibited by its selective preincubation with GSNO, but not by preincubation of JAK2 with GSNO, indicating that GSNO-mediated mechanisms inhibit STAT3 phosphorylation through S-nitrosylation of STAT3 rather than JAK2. In this study, we identified that Cys(259) was the target Cys residue of GSNO-mediated S-nitrosylation of STAT3. The replacement of Cys(259) residue with Ala abolished the inhibitory role of GSNO in IL-6-induced STAT3 phosphorylation and transactivation, suggesting the role of Cys(259) S-nitrosylation in STAT3 phosphorylation. Innovation: Microglial proliferation is regulated by NO via S-nitrosylation of STAT3 (Cys(259)) and inhibition of STAT3 (Tyr(705)) phosphorylation. Conclusion: Our results indicate the regulation of STAT3 by NO-based post-translational modification (S-nitrosylation). These findings have important implications for the development of new therapeutics targeting STAT3 for treating diseases associated with inflammatory/immune responses and abnormal cell proliferation, including cancer. Antioxid. Redox Signal. 20, 2514-2527. C1 [Kim, Jinsu; Singh, Inderjit] Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA. [Won, Je-Seong; Singh, Avtar K.] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA. [Singh, Avtar K.] Ralph H Johnson Vet Adm Med Ctr, Pathol & Lab Med Serv, Charleston, SC USA. [Sharma, Anand K.; Singh, Inderjit] Med Univ S Carolina, Dept Radiat Oncol, Charleston, SC 29425 USA. RP Singh, I (reprint author), Med Univ S Carolina, Dept Pediat, 173 Ashley Ave CRI 516, Charleston, SC 29425 USA. EM singhi@musc.edu FU NIH; VA [NS072511, BX001062, NS037766, BX001072] FX This work was supported by grants from NIH and VA (NS072511, BX001062, NS037766 and BX001072). We also acknowledge Ms. Joyce Bryan and Ms. Chara Williams for their help in procurement of animals and supplies. NR 60 TC 13 Z9 13 U1 1 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1523-0864 EI 1557-7716 J9 ANTIOXID REDOX SIGN JI Antioxid. Redox Signal. PD JUN 1 PY 2014 VL 20 IS 16 BP 2514 EP 2527 DI 10.1089/ars.2013.5223 PG 14 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA AG9SM UT WOS:000335760000003 PM 24063605 ER PT J AU Tyler, KL AF Tyler, Kenneth L. TI Current developments in understanding of West Nile virus central nervous system disease SO CURRENT OPINION IN NEUROLOGY LA English DT Review DE acute flaccid paralysis; antiviral therapy; encephalitis; meningitis; vaccine; West Nile virus ID UNITED-STATES; T-CELLS; ANTIVIRAL RESPONSE; FLACCID PARALYSIS; CHIMERIC VACCINE; IMMUNE-RESPONSE; INFECTION; ENCEPHALITIS; PATHOGENESIS; OUTBREAK AB Purpose of reviewWest Nile virus (WNV) is the most important cause of epidemic encephalitis in the United States. We review articles published in the last 18months related to the epidemiology, immunology, clinical features, and treatment of this disease.Recent findingsThere was a resurgence in WNV disease in the United States in 2012. The WNV strain now predominant in the United States (NA/WN02) differs from the initial emergent isolate in 1999 (NY99). However, differences in the genetics of currently circulating United States WNV strains do not explain variations in epidemic magnitude or disease severity. Innate and acquired immunity are critical in control of WNV, and in some cases pathways are central nervous system specific. The clinical features of infection are now well understood, although nonconfirmed observations of chronic viral excretion in urine remain controversial. There is no specific antiviral therapy for WNV, but studies of antivirals specific for other flaviviruses may identify agents with promise against WNV. Phase I and II human WNV vaccine clinical trials have established that well tolerated and immunogenic WNV vaccines can be developed.SummaryWNV remains an important public health problem. Although recent studies have significantly increased our understanding of host immune and genetic factors involved in control of WNV infection, no specific therapy is yet available. Development of a well tolerated, immunogenic, and effective vaccine against WNV is almost certainly feasible, but economic factors and the lack of predictability of the magnitude and location of outbreaks are problematic for designing phase III trials and ultimate licensure. C1 [Tyler, Kenneth L.] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO 80045 USA. [Tyler, Kenneth L.] Eastern Colorado Healthcare Syst, Denver Vet Affairs Med Ctr, Denver, CO USA. RP Tyler, KL (reprint author), Univ Colorado, Sch Med, Dept Neurol, Mailstop B-182,12700 East 19th Ave, Aurora, CO 80045 USA. EM ken.tyler@ucdenver.edu OI Tyler, Kenneth/0000-0003-3294-5888 FU NINDS [1 R01 NS076512]; NIAID [1 R21 AI01064]; Department of Veterans Affairs (MERIT) [BX000963] FX K.L.T. is supported by grants from the NINDS (1 R01 NS076512), NIAID (1 R21 AI01064), and the Department of Veterans Affairs (MERIT Grant BX000963). NR 64 TC 7 Z9 7 U1 1 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1350-7540 EI 1473-6551 J9 CURR OPIN NEUROL JI Curr. Opin. Neurol. PD JUN PY 2014 VL 27 IS 3 BP 342 EP 348 DI 10.1097/WCO.0000000000000088 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AH2QQ UT WOS:000335966500013 PM 24722324 ER PT J AU Miller, PS Evangelista, LS Giger, JN Martinez-Maza, O Corvera-Tindel, T Magpantay, L Pena, G Doering, LV AF Miller, Pamela S. Evangelista, Lorraine S. Giger, Joyce Newman Martinez-Maza, Otoniel Corvera-Tindel, Teresita Magpantay, Larry Pena, Guadalupe Doering, Lynn V. TI Exhaustion, immuno-inflammation, and pathogen burden after cardiac surgery: An exploratory study SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING LA English DT Article DE vital exhaustion; inflammation; pathogen burden; Coronary heart disease; herpesviruses; cytokines ID C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; ANTIINFLAMMATORY CYTOKINE INTERLEUKIN-10; BYPASS GRAFT-SURGERY; VITAL EXHAUSTION; MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; SOCIOECONOMIC-STATUS; ADHESION MOLECULES; ANGINA-PECTORIS AB Background: Exhaustion, a consequence of prolonged stress characterized by unusual fatigue, is associated with increased risk of cardiac morbidity and mortality. In patients recovering from coronary artery bypass (CABG), little is known about the relationship of 1) immune-mediated inflammation and resultant endothelial activation, and 2) cumulative exposure to infectious pathogens (pathogen burden (PB)) implicated in coronary atherosclerosis to exhaustion. Aim: The aim of this exploratory study was to investigate the association of PB, inflammatory markers (interleukin (IL)-6, IL-10) and a marker of endothelial activation (soluble intercellular adhesion molecule-1 (sICAM-1)) to exhaustion. Methods: One to two months post-CABG, 42 individuals who met inclusion criteria were assessed for exhaustion using the Maastricht Interview for Vital Exhaustion. Serum IgG antibodies to herpes simplex virus (HSV)-1, HSV-2, cytomegalovirus, Epstein Barr virus, and inflammatory and endothelial activation markers were measured by enzyme-linked immunosorbent assay. Pathogen burden was defined as the total number of seropositive exposures: low (0-1), moderate (2-3), and high (4). Results: Prevalence of exhaustion was 40.5%. Relative to non-exhausted patients, exhausted patients demonstrated a higher frequency of moderate PB (h=0.73, p=0.04) but lower frequency of high PB (h=1.05, p=0.03). Exhaustion showed a non-significant trend for positive correlations with IL-6 and sICAM-1 levels, and inverse relation to PB. In subgroup analysis, exhausted patients had stronger correlations with IL-6 and IL-6:IL-10 and a tendency towards higher serum IL-10 concentrations compared with their non-exhausted counterparts. Conclusion: This hypothesis-generating study provides preliminary evidence that elevated post-CABG exhaustion may be associated with PB, inflammation, and endothelial activation. C1 [Miller, Pamela S.] Univ Calif San Francisco, Sch Nursing, San Francisco, CA 94143 USA. [Miller, Pamela S.; Giger, Joyce Newman; Corvera-Tindel, Teresita; Doering, Lynn V.] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA. [Evangelista, Lorraine S.] Univ Calif Irvine, Program Nursing Sci, Irvine, CA USA. [Giger, Joyce Newman] Amer Univ Hlth Sci, Signal Hill, CA USA. [Martinez-Maza, Otoniel] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA. [Martinez-Maza, Otoniel] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA. [Corvera-Tindel, Teresita] Vet Affairs Greater Los Angeles Hlth Care Syst, Nursing Res Dept, Los Angeles, CA USA. [Magpantay, Larry; Pena, Guadalupe] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA. RP Miller, PS (reprint author), Univ Calif San Francisco, Sch Nursing, 2 Koret Way,N411Y,Box 0606, San Francisco, CA 94143 USA. EM Pamela.Miller@ucsf.edu RI Martinez-Maza, Otoniel/B-2667-2009 OI Martinez-Maza, Otoniel/0000-0003-1364-0675 FU American Academy of Nurse Practitioners Foundation; Sigma Theta Tau International; Veterans Affairs Pre-doctoral Nurse Fellowship; James B. Pendleton Charitable Trust; McCarthy Family Foundation FX This work was supported by grants from the American Academy of Nurse Practitioners Foundation; Sigma Theta Tau International; and Veterans Affairs Pre-doctoral Nurse Fellowship. This work was carried out in the facilities of the UCLA AIDS Institute, which were supported, in part, by funds from the James B. Pendleton Charitable Trust and the McCarthy Family Foundation. NR 45 TC 1 Z9 1 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1474-5151 EI 1873-1953 J9 EUR J CARDIOVASC NUR JI Eur. J. Cardiovasc. Nurs. PD JUN PY 2014 VL 13 IS 3 BP 211 EP 220 DI 10.1177/1474515113482805 PG 10 WC Cardiac & Cardiovascular Systems; Nursing SC Cardiovascular System & Cardiology; Nursing GA AG8RO UT WOS:000335686100003 PM 23524631 ER PT J AU Labarere, J Renaud, B Fine, MJ AF Labarere, Jose Renaud, Bertrand Fine, Michael J. TI Erratum to: How to derive and validate clinical prediction models for use in intensive care medicine (vol 40, pg 513, 2014) SO INTENSIVE CARE MEDICINE LA English DT Correction C1 [Labarere, Jose] Univ Hosp, Qual Care Unit, F-38043 Grenoble, France. [Labarere, Jose] Univ Grenoble 1, CNRS, TIMC, UMR 5525, Grenoble, France. [Renaud, Bertrand] Cochin Hosp, AP HP, Emergency Dept, Paris, France. [Renaud, Bertrand] Hop Hotel Dieu, AP HP, Emergency Dept, F-75181 Paris, France. [Renaud, Bertrand] Fac Med Paris Descartes, Paris, France. [Fine, Michael J.] VA Pittsburgh Healthcare Syst, Vet Affairs Ctr Hlth Equity & Res Promot, Pittsburgh, PA USA. [Fine, Michael J.] Univ Pittsburgh, Med Ctr, Div Gen Internal Med, Pittsburgh, PA USA. [Labarere, Jose] UQEM, F-38043 Grenoble 9, France. RP Labarere, J (reprint author), UQEM, Pavillon Taillefer,CHU BP217, F-38043 Grenoble 9, France. EM JLabarere@chu-grenoble.fr RI Labarere, Jose/N-1688-2014 NR 1 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0342-4642 EI 1432-1238 J9 INTENS CARE MED JI Intensive Care Med. PD JUN PY 2014 VL 40 IS 6 BP 925 EP 925 DI 10.1007/s00134-014-3271-2 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AH6ZJ UT WOS:000336281100033 ER PT J AU Goveas, JS Espeland, MA Hogan, PE Tindle, HA Shih, RA Kotchen, JM Robinson, JG Barnes, DE Resnick, SM AF Goveas, Joseph S. Espeland, Mark A. Hogan, Patricia E. Tindle, Hilary A. Shih, Regina A. Kotchen, Jane M. Robinson, Jennifer G. Barnes, Deborah E. Resnick, Susan M. TI Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY LA English DT Article DE depression; cognitive decline; vascular risk factors; cardiovascular disease; women; dementia; depressive symptoms ID LATE-LIFE DEPRESSION; APOLIPOPROTEIN-E GENOTYPE; PRIMARY-CARE PATIENTS; GERIATRIC DEPRESSION; VASCULAR DEPRESSION; POSTMENOPAUSAL WOMEN; ALZHEIMER-DISEASE; IMPAIRMENT; DEMENTIA; RISK AB Elevated depressive symptoms (DS) are associated with incident mild cognitive impairment and probable dementia in postmenopausal women. We examined the association of elevated DS with domain-specific cognitive changes and the moderating role of cardiovascular risk factor severity and cardiovascular disease (CVD). A total of 2221 elderly women who participated in the Women's Health Initiative Study of Cognitive Aging were separated into those with (N = 204) and without (N = 2017) elevated DS. The DS and multidomain cognitive outcomes were measured annually for an average follow-up of 5.04 years. Women with elevated DS showed baseline multidomain cognitive deficits but longitudinal declines in global cognition only. Persistent DS was related to greater global cognition, verbal knowledge and fluency, and memory declines. Significant DS-CVD interactions were observed cross-sectionally (but not longitudinally) for figural memory and fine motor speed. Future studies should investigate the role of nonvascular mechanisms linking DS and cognitive decline. C1 [Goveas, Joseph S.] Med Coll Wisconsin, Dept Psychiat & Behav Med, Milwaukee, WI 53226 USA. [Espeland, Mark A.; Hogan, Patricia E.] Wake Forest Univ Hlth Sci, Dept Biostat Sci, Winston Salem, NC USA. [Tindle, Hilary A.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. [Shih, Regina A.] RAND Corp, Arlington, VA USA. [Kotchen, Jane M.] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA. [Kotchen, Jane M.] Med Coll Wisconsin, Clin & Translat Sci Inst, Milwaukee, WI 53226 USA. [Robinson, Jennifer G.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA. [Barnes, Deborah E.] Univ Calif San Francisco, Dept Psychiat & Epidemiol, San Francisco, CA 94143 USA. [Barnes, Deborah E.] Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA. [Barnes, Deborah E.] San Francisco VA Med Ctr, Dept Psychiat, San Francisco, CA USA. [Resnick, Susan M.] NIA, Lab Behav Neurosci, Intramural Res Program, NIH, Baltimore, MD 21224 USA. RP Goveas, JS (reprint author), Med Coll Wisconsin, Dept Psychiat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA. EM jgoveas@mcw.edu FU National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, 44221]; Department of Health and Human Services; National Institute on Aging [NO1-AG-1-2106]; Intramural Research Program, National Institute on Aging; National Institutes of Health; Alzheimer's Association [NIRG-11-204070]; Extendicare Foundation; Brain & Behavior Research Foundation (NARSAD); Wyeth Pharmaceuticals; Brain and Behavior Research Foundation (previously NARSAD) young investigator award FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Women's Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221. The WHI Study of Cognitive Aging (WHISCA) was supported by the Department of Health and Human Services and the National Institute on Aging (NO1-AG-1-2106). SMR is supported by the Intramural Research Program, National Institute on Aging, and National Institutes of Health. JSG is supported by the Alzheimer's Association New Investigator NIRG-11-204070 and Extendicare Foundation, and previously by Brain & Behavior Research Foundation (NARSAD) young investigator, and Research for a Healthier Tomorrow, a Component of the Advancing a Healthier Wisconsin Endowment at MCW. The Women's Health Initiative Memory Study was funded in part by Wyeth Pharmaceuticals as an ancillary study to the WHI. DB's contributions were supported in part by Brain and Behavior Research Foundation (previously NARSAD) young investigator award. NR 46 TC 11 Z9 11 U1 3 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0891-9887 EI 1552-5708 J9 J GERIATR PSYCH NEUR JI J. Geriatr. Psychiatry Neurol. PD JUN PY 2014 VL 27 IS 2 BP 94 EP 102 DI 10.1177/0891988714522697 PG 9 WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry GA AH6DG UT WOS:000336220300004 PM 24584465 ER PT J AU Hay, RJ Johns, NE Williams, HC Bolliger, IW Dellavalle, RP Margolis, DJ Marks, R Naldi, L Weinstock, MA Wulf, SK Michaud, C Murray, CJL Naghavi, M AF Hay, Roderick J. Johns, Nicole E. Williams, Hywel C. Bolliger, Ian W. Dellavalle, Robert P. Margolis, David J. Marks, Robin Naldi, Luigi Weinstock, Martin A. Wulf, Sarah K. Michaud, Catherine Murray, Christopher J. L. Naghavi, Mohsen TI The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Article ID SYSTEMATIC ANALYSIS; DISABILITY WEIGHTS; COMMUNITY; SCABIES; ECZEMA; DERMATOLOGY; ETHIOPIA; CRITERIA AB The Global Burden of Disease (GBD) Study 2010 estimated the GBD attributable to 15 categories of skin disease from 1990 to 2010 for 187 countries. For each of the following diseases, we performed systematic literature reviews and analyzed resulting data: eczema, psoriasis, acne vulgaris, pruritus, alopecia areata, decubitus ulcer, urticaria, scabies, fungal skin diseases, impetigo, abscess, and other bacterial skin diseases, cellulitis, viral warts, molluscum contagiosum, and non-melanoma skin cancer. We used disability estimates to determine nonfatal burden. Three skin conditions, fungal skin diseases, other skin and subcutaneous diseases, and acne were in the top 10 most prevalent diseases worldwide in 2010, and eight fell into the top 50; these additional five skin problems were pruritus, eczema, impetigo, scabies, and molluscum contagiosum. Collectively, skin conditions ranged from the 2nd to 11th leading cause of years lived with disability at the country level. At the global level, skin conditions were the fourth leading cause of nonfatal disease burden. Using more data than has been used previously, the burden due to these diseases is enormous in both high- and low-income countries. These results argue strongly to include skin disease prevention and treatment in future global health strategies as a matter of urgency. C1 [Hay, Roderick J.] Int Fdn Dermatol, London W1T 5HQ, England. [Johns, Nicole E.; Bolliger, Ian W.; Wulf, Sarah K.; Murray, Christopher J. L.; Naghavi, Mohsen] Univ Washington, Inst Hlth Metr & Evaluat, Washington, DC USA. [Williams, Hywel C.] Univ Nottingham, Ctr Evidence Based Dermatol, Nottingham NG7 2RD, England. [Dellavalle, Robert P.] Denver VA Med Ctr, Dermatol Serv, Denver, CO USA. [Margolis, David J.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Margolis, David J.] Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Marks, Robin] Skin & Canc Fdn, Melbourne, Vic, Australia. [Naldi, Luigi] Azienda Osped Papa Giovanni XXIII, Dept Dermatol, Bergamo, Italy. [Weinstock, Martin A.] Brown Univ, Div Dermatoepidemiol, Providence, RI 02912 USA. [Michaud, Catherine] China Med Board, Cambridge, MA USA. RP Hay, RJ (reprint author), Int Fdn Dermatol, 4 Fitzroy Sq, London W1T 5HQ, England. EM roderick.hay@ifd.org RI Bolliger, Ian/C-4207-2016; Naldi, Luigi/K-6343-2016 OI Bolliger, Ian/0000-0001-8055-297X; Naldi, Luigi/0000-0002-3160-2835; Johns, Nicole/0000-0003-4513-4582 NR 29 TC 117 Z9 119 U1 47 U2 88 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD JUN PY 2014 VL 134 IS 6 BP 1527 EP 1534 DI 10.1038/jid.2013.446 PG 8 WC Dermatology SC Dermatology GA AH5TJ UT WOS:000336193700010 PM 24166134 ER PT J AU Hage, FG Garcia, EV AF Hage, Fadi G. Garcia, Ernest V. TI The independent prognostic value of left ventricular dyssynchrony SO JOURNAL OF NUCLEAR CARDIOLOGY LA English DT Editorial Material ID PHASE-ANALYSIS; MECHANICAL DYSSYNCHRONY; CARDIOMYOPATHY; DEATH; ERA C1 [Hage, Fadi G.] Univ Alabama Birmingham, Div Cardiovasc Dis, Birmingham, AL 35294 USA. [Hage, Fadi G.] Birmingham Vet Affairs Med Ctr, Cardiol Sect, Birmingham, AL USA. [Garcia, Ernest V.] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USA. RP Hage, FG (reprint author), Univ Alabama Birmingham, Div Cardiovasc Dis, Lyons Harrison Res Bldg 314,1900 Univ BLVD, Birmingham, AL 35294 USA. EM fadihage@uab.edu OI Hage, Fadi/0000-0002-1397-4942 NR 18 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-3581 EI 1532-6551 J9 J NUCL CARDIOL JI J. Nucl. Cardiol. PD JUN PY 2014 VL 21 IS 3 BP 541 EP 543 DI 10.1007/s12350-014-9878-4 PG 3 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA AH6YI UT WOS:000336278000013 PM 24623398 ER PT J AU Erickson, MA Morofuji, Y Owen, JB Banks, WA AF Erickson, Michelle A. Morofuji, Yoichi Owen, Joshua B. Banks, William A. TI Rapid Transport of CCL11 across the Blood-Brain Barrier: Regional Variation and Importance of Blood Cells SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID MICROVASCULAR ENDOTHELIAL-CELLS; COGNITIVE FUNCTION; RAT-BRAIN; EOTAXIN; CAPILLARY; MOUSE; CHEMOKINE; RECEPTOR; PLASMA; NEUROGENESIS AB Increased blood levels of the eotaxin chemokine C-C motif ligand 11 (CCL11) in aging were recently shown to negatively regulate adult hippocampal neurogenesis. How circulating CCL11 could affect the central nervous system (CNS) is not clear, but one possibility is that it can cross the blood-brain barrier (BBB). Here, we show that CCL11 undergoes bidirectional transport across the BBB. Transport of CCL11 from blood into whole brain (influx) showed biphasic kinetics, with a slow phase preceding a rapid phase of uptake. We found that the slow phase was explained by binding of CCL11 to cellular components in blood, whereas the rapid uptake phase was mediated by direct interactions with the BBB. CCL11, even at high doses, did not cause BBB disruption. All brain regions except striatum showed a delayed rapid-uptake phase. Striatum had only an early rapid-uptake phase, which was the fastest of any brain region. We also observed a slow but saturable transport system for CCL11 from brain to blood. C-C motif ligand 3 (CCR3), an important receptor for CCL11, did not facilitate CCL11 transport across the BBB, although high concentrations of a CCR3 inhibitor increased brain uptake without causing BBB disruption. Our results indicate that CCL11 in the circulation can access many regions of the brain outside of the neurogenic niche via transport across the BBB. This suggests that blood-borne CCL11 may have important physiologic functions in the CNS and implicates the BBB as an important regulator of physiologic versus pathologic effects of this chemokine. C1 [Erickson, Michelle A.] Univ Penn, Dept Pathol, Sch Dent Med, Philadelphia, PA 19104 USA. [Erickson, Michelle A.; Morofuji, Yoichi; Owen, Joshua B.; Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA. [Erickson, Michelle A.; Morofuji, Yoichi; Owen, Joshua B.; Banks, William A.] Univ Washington, Sch Med, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA. [Owen, Joshua B.] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA. [Morofuji, Yoichi] Nagasaki Univ, Dept Neurosurg, Nagasaki 852, Japan. RP Banks, WA (reprint author), Bldg 1,Rm 810A,1660 Columbian Way, Seattle, WA 98108 USA. EM wabanks1@u.washington.edu FU National Institutes of Health National Institute on Aging [R01-AG029839]; National Institutes of Health National Institute of Neurological Disorders and Stroke [R01NS051334] FX This work was supported by the National Institutes of Health National Institute on Aging [Grant R01-AG029839]; and National Institutes of Health National Institute of Neurological Disorders and Stroke [Grant R01NS051334]. NR 42 TC 13 Z9 13 U1 0 U2 4 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 EI 1521-0103 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD JUN PY 2014 VL 349 IS 3 BP 497 EP 507 DI 10.1124/jpet.114.213074 PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AH5GJ UT WOS:000336156200014 PM 24706984 ER PT J AU Saunders, RS Fernandes-Taylor, S Kind, AJH Engelbert, TL Greenberg, CC Smith, MA Matsumura, JS Kent, KC AF Saunders, Richard S. Fernandes-Taylor, Sara Kind, Amy J. H. Engelbert, Travis L. Greenberg, Caprice C. Smith, Maureen A. Matsumura, Jon S. Kent, K. Craig TI Rehospitalization to primary versus different facilities following abdominal aortic aneurysm repair SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID RURAL PATIENTS; SURGERY; VOLUME; CARE; REGIONALIZATION; READMISSIONS; HOSPITALS; MORTALITY; RESECTION; FAILURE AB Objective: Reducing readmissions represents a unique opportunity to improve care and reduce health care costs and is the focus of major payers. A large number of surgical patients are readmitted to hospitals other than where the primary surgery was performed, resulting in clinical decisions that do not incorporate the primary surgeon and potentially alter outcomes. This study characterizes readmission to primary vs different hospitals after abdominal aortic aneurysm (AAA) repair and examines the implications with regard to mortality and cost. Methods: Patients who underwent open or endovascular aneurysm repair for AAA were identified from the Centers for Medicare and Medicaid Services Chronic Conditions Warehouse, a random 5% national sample of Medicare beneficiaries from 2005 to 2009. Outcomes for patients who underwent AAA repair and were readmitted within 30 days of initial discharge were compared based on readmission location (primary vs different hospital). Results: A total of 885 patients underwent AAA repair and were readmitted within 30 days. Of these, 626 (70.7%) returned to the primary facility, and 259 (29.3%) returned to a different facility. Greater distance from patient residence to the primary hospital was the strongest predictor of readmission to a different facility. Patients living 50 to 100 miles from the primary hospital were more likely to be readmitted to a different hospital compared with patients living <10 miles away (odds ratio, 8.50; P < .001). Patients with diagnoses directly related to the surgery (eg, wound infection) were more likely to be readmitted to the primary hospital, whereas medical diagnoses (eg, pneumonia and congestive heart failure) were more likely to be treated at a different hospital. There was no statistically significant difference in mortality between patients readmitted to a different or the primary hospital. Median total 30-day payments were significantly lower at different vs primary hospitals (primary, $11,978 vs different, $11,168; P = .04). Conclusions: Readmission to a different facility after AAA repair is common and occurs more frequently than for the overall Medicare population. Patients travelling a greater distance for AAA repair are more likely to return to different vs the primary hospital when further care is required. For AAA repair, quality healthcare may be achieved at marginally lower cost and with greater patient convenience for selected readmissions at hospitals other than where the initial procedure was performed. C1 [Saunders, Richard S.; Fernandes-Taylor, Sara; Engelbert, Travis L.; Greenberg, Caprice C.; Matsumura, Jon S.; Kent, K. Craig] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Surg Outcomes Res Program WiSOR, Dept Surg, Madison, WI USA. [Kind, Amy J. H.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Geriatr, Madison, WI USA. [Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA. [Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Family Med, Madison, WI USA. [Kind, Amy J. H.] William S Middleton Hosp, GRECC, US Dept Vet Affairs, Madison, WI USA. RP Kent, KC (reprint author), H4 710 Clin Sci Ctr, 600 Highland Ave, Madison, WI 53792 USA. EM kent@surgery.wisc.edu FU Health Innovation Program; University of Wisconsin School of Medicine and Public Health from The Wisconsin Partnership Program; Community-Academic Partnerships core of the University of Wisconsin Institute for Clinical and Translational Research (UW ICTR) through the National Center for Advancing Translational Sciences (NCATS) [UL1TR000427] FX This project was supported in part by the Health Innovation Program, the University of Wisconsin School of Medicine and Public Health from The Wisconsin Partnership Program, and the Community-Academic Partnerships core of the University of Wisconsin Institute for Clinical and Translational Research (UW ICTR) through the National Center for Advancing Translational Sciences (NCATS), grant UL1TR000427. NR 27 TC 12 Z9 12 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 BP 1502 EP + DI 10.1016/j.jvs.2013.12.015 PG 11 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AH8DH UT WOS:000336363800004 PM 24491237 ER PT J AU Kougias, P Sharath, S Barshes, NR Lowery, B Garcia, A Pak, T Bechara, CF Pisimisis, G AF Kougias, Panos Sharath, Sherene Barshes, Neal R. Lowery, Briauna Garcia, Andrea Pak, Taemee Bechara, Carlos F. Pisimisis, George TI Impact of cumulative intravascular contrast exposure on renal function in patients with occlusive and aneurysmal vascular disease SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 38th Annual Spring Meeting of the Peripheral-Vascular-Surgery-Society CY MAY 29, 2013 CL San Francisco, CA SP Peripheral Vasc Surg Soc ID GLOMERULAR-FILTRATION-RATE; CHRONIC KIDNEY-DISEASE; RISK-FACTORS; INDUCED NEPHROPATHY; PROXIMAL FIXATION; REPAIR; DYSFUNCTION; CONSEQUENCES; TERM AB Objective: Patients with occlusive or aneurysmal vascular disease are repeatedly exposed to intravascular (IV) contrast for diagnostic or therapeutic purposes. We sought to determine the long-term impact of cumulative iodinated IV contrast exposure (CIVCE) on renal function; the latter was defined by means of National Kidney Foundation (NKF) criteria. Methods: We performed a longitudinal study of consecutive patients without renal insufficiency at baseline (NFK stage I or II) who underwent interventions for arterial occlusive or aneurysmal disease. We collected detailed data on any IV iodinated contrast exposure (including diagnostic or therapeutic angiography, cardiac catheterization, IV pyelography, computed tomography with IV contrast, computed tomographic angiography); medication exposure throughout the observation period; comorbidities; and demographics. The primary end point was the development of renal failure (RF) (defined as NFK stage 4 or 5). Analysis was performed with the use of a shared frailty model with clustering at the patient level. Results: Patients (n = 1274) had a mean follow-up of 5.8 (range, 2.2-14) years. In the multivariate model with RF as the dependent variable and after adjusting for the statistically significant covariates of baseline renal function (hazard ratio [HR], 0.95; P < .001), diabetes (HR, 1.8; P = .007), use of an angiotensin-converting enzyme inhibitor (HR, 0.63; P = .03), use of antiplatelets (HR, 0.5; P = .01), cumulative number of open vascular operations performed (HR, 1.2; P = .001), and congestive heart failure (HR, 3.2; P < .001), CIVCE remained an independent predictor for RF development (HR, 1.1; P < .001). In the multivariate survival analysis model and after adjusting for the statistically significant covariates of perioperative myocardial infarction (HR, 3.9; P < .001), age at entry in the cohort (HR, 1.05; P = .035), total number of open operations (HR, 1.51; P < .001), and serum albumin (HR, 0.47; P < .001), CIVCE was an independent predictor of death (HR, 1.07; P < .001). Conclusions: Cumulative IV contrast exposure is an independent predictor of RF and death in patients with occlusive and aneurysmal vascular disease. C1 [Kougias, Panos; Sharath, Sherene; Barshes, Neal R.; Lowery, Briauna; Bechara, Carlos F.; Pisimisis, George] Michael E DeBakey VA Med Ctr, Dept Surg, Houston, TX USA. [Kougias, Panos; Barshes, Neal R.; Garcia, Andrea; Pak, Taemee; Bechara, Carlos F.; Pisimisis, George] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA. RP Kougias, P (reprint author), Houston VAMC, Dept Surg, 2002 Holcombe Blvd OCL 112, Houston, TX 77030 USA. EM pkougias@bcm.edu NR 17 TC 3 Z9 3 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 BP 1644 EP 1650 DI 10.1016/j.jvs.2013.12.039 PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AH8DH UT WOS:000336363800025 PM 24560864 ER PT J AU Lee, LC Ge, L Zhang, ZH Pease, M Nikolic, SD Mishra, R Ratcliffe, MB Guccione, JM AF Lee, Lik Chuan Ge, Liang Zhang, Zhihong Pease, Matthew Nikolic, Serjan D. Mishra, Rakesh Ratcliffe, Mark B. Guccione, Julius M. TI Patient-specific finite element modeling of the Cardiokinetix Parachute(A (R)) device: effects on left ventricular wall stress and function SO MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING LA English DT Article DE Myocardial infarction; Remodeling; Finite element method; Surgical ventricular restoration ID CHRONIC HEART-FAILURE; MYOCARDIAL-INFARCTION; MRI; RESTORATION; MECHANICS; ANEURYSM AB The Parachute(A (R)) (Cardiokinetix, Inc., Menlo Park, California) is a catheter-based device intended to reverse left ventricular (LV) remodeling after antero-apical myocardial infarction. When deployed, the device partitions the LV into upper and lower chambers. To simulate its mechanical effects, we created a finite element LV model based on computed tomography (CT) images from a patient before and 6 months after Parachute(A (R)) implantation. Acute mechanical effects were determined by in silico device implantation (VIRTUAL-Parachute). Chronic effects of the device were determined by adjusting the diastolic and systolic material parameters to better match the 6-month post-implantation CT data and LV pressure data at end-diastole (ED) (POST-OP). Regional myofiber stress and pump function were calculated in each case. The principal finding is that VIRTUAL-Parachute was associated with a 61.2 % reduction in the lower chamber myofiber stress at ED. The POST-OP model was associated with a decrease in LV diastolic stiffness and a larger reduction in myofiber stress at the upper (27.1 %) and lower chamber (78.4 %) at ED. Myofiber stress at end-systole and stroke volume was little changed in the POST-OP case. These results suggest that the primary mechanism of Parachute(A (R)) is a reduction in ED myofiber stress, which may reverse eccentric post-infarct LV hypertrophy. C1 [Lee, Lik Chuan; Ge, Liang; Ratcliffe, Mark B.; Guccione, Julius M.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA. [Lee, Lik Chuan; Ge, Liang; Ratcliffe, Mark B.; Guccione, Julius M.] Univ Calif San Francisco, Dept Bioengn, San Francisco, CA 94143 USA. [Lee, Lik Chuan; Ge, Liang; Zhang, Zhihong; Mishra, Rakesh; Ratcliffe, Mark B.; Guccione, Julius M.] San Francisco VA Med Ctr, Div Surg Serv 112, San Francisco, CA 94121 USA. [Pease, Matthew; Nikolic, Serjan D.] Cardiokinetix Inc, Menlo Pk, CA USA. [Mishra, Rakesh] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. RP Ratcliffe, MB (reprint author), San Francisco VA Med Ctr, Div Surg Serv 112, 4150 Clement St, San Francisco, CA 94121 USA. EM mark.ratcliffe@va.gov FU NIH [R01-HL-084431, R01-HL-077921, R01-HL-118627] FX This study was supported by an unrestricted gift from Cardiokinetix and NIH grants R01-HL-084431 (Dr. Ratcliffe), R01-HL-077921 and R01-HL-118627 (Dr. Guccione). NR 23 TC 15 Z9 17 U1 0 U2 4 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0140-0118 EI 1741-0444 J9 MED BIOL ENG COMPUT JI Med. Biol. Eng. Comput. PD JUN PY 2014 VL 52 IS 6 BP 557 EP 566 DI 10.1007/s11517-014-1159-5 PG 10 WC Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematical & Computational Biology; Medical Informatics SC Computer Science; Engineering; Mathematical & Computational Biology; Medical Informatics GA AH8HO UT WOS:000336378200005 PM 24793158 ER PT J AU Heatwole, C Bode, R Johnson, N Dekdebrun, J Dilek, N Heatwole, M Hilbert, JE Luebbe, E Martens, W Mcdermott, MP Rothrock, N Thornton, C Vickrey, BG Victorson, D Moxley, R AF Heatwole, Chad Bode, Rita Johnson, Nicholas Dekdebrun, Jeanne Dilek, Nuran Heatwole, Mark Hilbert, James E. Luebbe, Elizabeth Martens, William Mcdermott, Michael P. Rothrock, Nan Thornton, Charles Vickrey, Barbara G. Victorson, David Moxley, Richard, III TI MYOTONIC DYSTROPHY HEALTH INDEX: INITIAL EVALUATION OF A DISEASE-SPECIFIC OUTCOME MEASURE SO MUSCLE & NERVE LA English DT Article DE pain management; pain assessment; myotonic dystrophy type 1; facioscapulohumeral muscular dystrophy; rehabilitation ID PATIENT-REPORTED OUTCOMES; QUALITY-OF-LIFE; MUSCULAR-DYSTROPHY; DRUG DEVELOPMENT; CTG REPEAT; PERSPECTIVE; VALIDITY; TYPE-1; TRIALS; GENE AB Introduction: We examined the effects of pain site and intensity on function in patients with myotonic dystrophy type 1 (DM1) and facioscapulohumeral muscular dystrophy (FSHD) and chronic pain. Methods: Questionnaires assessing pain sites, pain extent (number of sites), pain intensity, and pain interference were completed by 182 individuals with DM1 (43%) or FSHD (57%) and chronic pain. Results: There was a positive association between pain extent and intensity with pain interference, and a negative association with psychological functioning in both DM1 and FSHD. Pain intensity at specific sites had differential impact beyond the effects of pain intensity alone. Head pain intensity independently affected psychological functioning, whereas leg, foot, hip, and knee pain contributed independently to the prediction of pain interference. Conclusions: Pain site and intensity differentially modulates the effect of chronic pain on function in DM1 and FSHD patients. Researchers and clinicians should consider these factors when assessing and treating pain. Muscle Nerve 49: 900-905, 2014 C1 [Heatwole, Chad; Dekdebrun, Jeanne; Dilek, Nuran; Hilbert, James E.; Luebbe, Elizabeth; Martens, William; Mcdermott, Michael P.; Thornton, Charles; Moxley, Richard, III] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA. [Bode, Rita] Psychometr Consultant, Chicago, IL USA. [Johnson, Nicholas] Univ Utah, Dept Neurol, Salt Lake City, UT USA. [Mcdermott, Michael P.] Univ Rochester, Med Ctr, Dept Biostat & Computat Biol, Rochester, NY 14642 USA. [Rothrock, Nan; Victorson, David] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Vickrey, Barbara G.] Univ Calif Los Angeles, Med Ctr, David Geffen Sch Med, Los Angeles, CA 90024 USA. [Vickrey, Barbara G.] Greater Los Angeles VA HealthCare Syst, Los Angeles, CA USA. RP Heatwole, C (reprint author), Univ Rochester, Med Ctr, Dept Neurol, 601 Elmwood Ave,Box 673, Rochester, NY 14642 USA. EM chad_heatwole@urmc.rochester.edu FU National Institute of Arthritis and Musculoskeletal and Skin Disorders [1K23AR055947]; Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center [NINDS U54NS48843]; Muscular Dystrophy Association; Saunders Family Fund; University of Rochester CTSA award from the National Center for Research Resources [UL1 RR024160]; National Center for Advancing Translational Sciences of the National Institutes of Health FX Partial support for this research was provided by the National Institute of Arthritis and Musculoskeletal and Skin Disorders (1K23AR055947), the Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (NINDS U54NS48843), the Muscular Dystrophy Association, and the Saunders Family Fund. The project described in this publication was also supported by the University of Rochester CTSA award number UL1 RR024160 from the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional information regarding the MDHI is available at the Neuromuscular Institute of Quality-of-Life Studies and Outcome Measure Development website www.QOLINSTITUTE.com and MDHI licensing opportunities can be reviewed at: www.urmc.rochester.edu/techtransfer. NR 27 TC 6 Z9 6 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0148-639X EI 1097-4598 J9 MUSCLE NERVE JI Muscle Nerve PD JUN PY 2014 VL 49 IS 6 BP 906 EP 914 DI 10.1002/mus.24079 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AH2MA UT WOS:000335954400016 PM 24142420 ER PT J AU Peng, ZC Zhang, NH Chandra, D Homanics, GE Olsen, RW Houser, CR AF Peng, Zechun Zhang, Nianhui Chandra, Dave Homanics, Gregg E. Olsen, Richard W. Houser, Carolyn R. TI Altered Localization of the delta Subunit of the GABA(A) Receptor in the Thalamus of alpha 4 Subunit Knockout Mice SO NEUROCHEMICAL RESEARCH LA English DT Article DE Immunohistochemistry; Non-synaptic GABA receptors; Plasticity; Receptor trafficking; Tonic inhibition; Ventrobasal nucleus ID TEMPORAL-LOBE EPILEPSY; AMINOBUTYRIC ACID(A) RECEPTORS; INTERMITTENT ETHANOL TREATMENT; CEREBELLAR GRANULE CELLS; ADULT-RAT BRAIN; TONIC INHIBITION; PHARMACOLOGICAL CHARACTERIZATION; IMMUNOCYTOCHEMICAL DISTRIBUTION; ENDOPLASMIC-RETICULUM; BEHAVIORAL-RESPONSES AB The alpha 4 subunit of the GABA(A) receptor (GABA(A)R) is highly expressed in the thalamus where receptors containing the alpha 4 and delta subunits are major mediators of tonic inhibition. The alpha 4 subunit also exhibits considerable plasticity in a number of physiological and pathological conditions, raising questions about the expression of remaining GABA(A)R subunits when the alpha 4 subunit is absent. Immunohistochemical studies of an alpha 4 subunit knockout (KO) mouse revealed a substantial decrease in delta subunit expression in the ventrobasal nucleus of the thalamus as well as other forebrain regions where the alpha 4 subunit is normally expressed. In contrast, several subunits associated primarily with phasic inhibition, including the alpha 1 and gamma 2 subunits, were moderately increased. Intracellular localization of the delta subunit was also altered. While delta subunit labeling was decreased within the neuropil, some labeling remained in the cell bodies of many neurons in the ventrobasal nucleus. Confocal microscopy demonstrated co-localization of this labeling with an endoplasmic reticulum marker, and electron microscopy demonstrated increased immunogold labeling near the endoplasmic reticulum in the alpha 4 KO mouse. These results emphasize the strong partnership of the delta and alpha 4 subunit in the thalamus and suggest that the alpha 4 subunit of the GABA(A)R plays a critical role in trafficking of the delta subunit to the neuronal surface. The findings also suggest that previously observed reductions in tonic inhibition in the alpha 4 subunit KO mouse are likely to be related to alterations in delta subunit expression, in addition to loss of the alpha 4 subunit. C1 [Peng, Zechun; Zhang, Nianhui; Houser, Carolyn R.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA. [Chandra, Dave; Homanics, Gregg E.] Univ Pittsburgh, Dept Anesthesiol & Pharmacol & Chem Biol, Pittsburgh, PA USA. [Olsen, Richard W.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA. [Houser, Carolyn R.] VA Greater Los Angeles Healthcare Syst, Res Serv, Los Angeles, CA USA. RP Houser, CR (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, CHS 73-235, Los Angeles, CA 90095 USA. EM houser@mednet.ucla.edu FU National Institutes of Health [NS075245, AA14022, AA13004, AA007680]; Veterans Affairs Medical Research Funds FX We thank Drs. Jean-Marc Fritschy and Werner Sieghart for generously sharing their GABAAR subunit-specific antisera that have made these studies possible. We also thank Christine Huang and Yliana Cetina for outstanding assistance with tissue processing and figure preparation. This work was supported by National Institutes of Health Grants NS075245 (CRH), AA14022 and AA13004 (GEH), AA007680 (RWO), and Veterans Affairs Medical Research Funds (CRH). NR 72 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-3190 EI 1573-6903 J9 NEUROCHEM RES JI Neurochem. Res. PD JUN PY 2014 VL 39 IS 6 SI SI BP 1104 EP 1117 DI 10.1007/s11064-013-1202-1 PG 14 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA AH6WJ UT WOS:000336272500013 PM 24352815 ER PT J AU Kim, WH Singh, V Chung, MK Hinrichs, C Pachauri, D Okonkwo, OC Johnson, SC AF Kim, Won Hwa Singh, Vikas Chung, Moo K. Hinrichs, Chris Pachauri, Deepti Okonkwo, Ozioma C. Johnson, Sterling C. CA Alzheimer's Dis Neuroimaging Initi TI Multi-resolutional shape features via non-Euclidean wavelets: Applications to statistical analysis of cortical thickness SO NEUROIMAGE LA English DT Article DE Non-Euclidean wavelet; Multi-resolution analysis; Graph wavelets; Shape analysis; Cortical thickness discrimination; Alzheimer's disease ID ALZHEIMERS-DISEASE; SURFACE-AREA; GRAY-MATTER; HEAT KERNEL; CHILDREN; CT; ADOLESCENTS; MRI; REPRESENTATION; SCHIZOPHRENIA AB Statistical analysis on arbitrary surface meshes such as the cortical surface is an important approach to understanding brain diseases such as Alzheimer's disease (AD). Surface analysis may be able to identify specific cortical patterns that relate to certain disease characteristics or exhibit differences between groups. Our goal in this paper is to make group analysis of signals on surfaces more sensitive. To do this, we derive multi-scale shape descriptors that characterize the signal around each mesh vertex, i.e., its local context, at varying levels of resolution. In order to define such a shape descriptor, we make use of recent results from harmonic analysis that extend traditional continuous wavelet theory from the Euclidean to a non-Euclidean setting (i.e., a graph, mesh or network). Using this descriptor, we conduct experiments on two different datasets, the Alzheimer's Disease NeuroImaging Initiative (ADNI) data and images acquired at the Wisconsin Alzheimer's Disease Research Center (W-ADRC), focusing on individuals labeled as having Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy controls. In particular, we contrast traditional univariate methods with our multi-resolution approach which show increased sensitivity and improved statistical power to detect a group-level effects. We also provide an open source implementation. (C) 2014 Elsevier Inc. All rights reserved. C1 [Kim, Won Hwa; Singh, Vikas; Hinrichs, Chris; Pachauri, Deepti] Univ Wisconsin, Dept Comp Sci, Madison, WI 53706 USA. [Singh, Vikas; Chung, Moo K.] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53705 USA. [Kim, Won Hwa; Singh, Vikas; Okonkwo, Ozioma C.; Johnson, Sterling C.] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI 53705 USA. [Okonkwo, Ozioma C.; Johnson, Sterling C.] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Alzheimers Dis Res Ctr, Madison, WI 53792 USA. RP Kim, WH (reprint author), Univ Wisconsin, Dept Comp Sci, 1210 W Dayton St, Madison, WI 53706 USA. EM wonhwa@cs.wisc.edu; vsingh@biostat.wisc.edu OI Kim, Won Hwa/0000-0001-5393-0883; Johnson, Sterling/0000-0002-8501-545X FU NIH [R01AG040396, R01AG021155, P30 AG010129, K01 AG030514]; NSF [RI 1116584]; NSF CAREER award [1252725]; UW ADRC [P50 AG033514]; Wisconsin Partnership Program; UW ICTR [1UL1RR025011]; CIBM pre-doctoral fellowship via NLM grant [5T15LM007359]; Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research FX We provide a freely downloadable implementation of this framework at http://pages.cs.wisc.edu/-wonhwa/CTA_toolbox/. This research was supported by funding from NIH R01AG040396, NIH R01AG021155, NSF RI 1116584, NSF CAREER award 1252725, UW ADRC (P50 AG033514), the Wisconsin Partnership Program, UW ICTR (1UL1RR025011)and Chris Hinrichs was supported by a CIBM pre-doctoral fellowship via NLM grant 5T15LM007359. We appreciate N. Maritza Dowling, Jennifer Oh, Vamsi Ithapu, Joon H. Lee and Gun W. Park for their help in processing the data and/or the preparation of this manuscript.; Data collection and sharing for this project were funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Alzheimer's Association; Alzheimer's Drug Discovery Foundation; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Mesa Scale Diagnostics, LLC.; NeuroRx Research; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseininated by the Laboratory for Neuro Imaging at the University of California, Los Angeles. This research was also supported by NIH grants P30 AG010129 and K01 AG030514. NR 52 TC 12 Z9 12 U1 0 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD JUN PY 2014 VL 93 BP 107 EP 123 DI 10.1016/j.neuroimage.2014.02.028 PN 1 PG 17 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA AH7WW UT WOS:000336347100010 PM 24614060 ER PT J AU Portelius, E Holtta, M Soininen, H Bjerke, M Zetterberg, H Westerlund, A Herukka, SK Blennow, K Mattsson, N AF Portelius, Erik Holtta, Mikko Soininen, Hilkka Bjerke, Maria Zetterberg, Henrik Westerlund, Anni Herukka, Sanna-Kaisa Blennow, Kaj Mattsson, Niklas TI Altered Cerebrospinal Fluid Levels of Amyloid beta and Amyloid Precursor-Like Protein 1 Peptides in Down's Syndrome SO NEUROMOLECULAR MEDICINE LA English DT Article DE Down's syndrome; Amyloid beta; Amyloid precursor-like protein 1; Mass spectrometry; Cerebrospinal fluid ID ALZHEIMERS-DISEASE; BRAIN; BIOMARKER; CLEAVAGE; SYSTEM AB Down's syndrome (DS) patients develop early Alzheimer's disease pathology with abundant cortical amyloid plaques, likely due to overproduction of the amyloid precursor protein (APP), which subsequently leads to amyloid beta (A beta) aggregation. This is reflected in cerebrospinal fluid (CSF) levels of the 42-amino acid long A beta peptide (A beta 1-42), which are increased in young DS patients and decreases with age. However, it is unclear whether DS also affects other aspects of A beta metabolism, including production of shorter C- and N-terminal truncated A beta peptides, and production of peptides from the amyloid precursor-like protein 1 (APLP1), which is related to APP, and cleaved by the same enzymatic processing machinery. APLP1-derived peptides may be surrogate markers for A beta 1-42 production in the brain. Here, we used hybrid immunoaffinity-mass spectrometry and enzyme-linked immunosorbent assays to monitor several A beta and APLP1 peptides in CSF from DS patients (n = 12) and healthy controls (n = 20). CSF levels of A beta 1-42 and three endogenous peptides derived from APLP1 (APL1 beta 25, APL1 beta 27 and APL1 beta 28) were decreased in DS compared with controls, while a specific A beta peptide, A beta 1-28, was increased in a majority of the DS individuals. This study indicates that DS causes previously unknown specific alterations of APP and APLP1 metabolism. C1 [Portelius, Erik; Holtta, Mikko; Bjerke, Maria; Zetterberg, Henrik; Westerlund, Anni; Blennow, Kaj; Mattsson, Niklas] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden. [Soininen, Hilkka; Herukka, Sanna-Kaisa] Kuopio Univ Hosp, SF-70210 Kuopio, Finland. [Soininen, Hilkka; Herukka, Sanna-Kaisa] Univ Eastern Finland, Inst Clin Med Neurol, Sch Med, Kuopio 70211, Finland. [Zetterberg, Henrik] UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England. [Mattsson, Niklas] Univ Calif San Francisco, San Francisco VA Med Ctr, CIND, San Francisco, CA USA. [Mattsson, Niklas] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA. RP Portelius, E (reprint author), Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden. EM erik.portelius@neuro.gu.se FU Swedish Research Council [14002, K2010-63P-21562-01-4, K2011-61X-20401-05-6]; Stiftelsen Gamla Tjanarinnor; Magn. Bergvalls Stiftelse; Gun och Bertil Stohnes Stiftelse; Swedish Brain Fund; Alzheimer Foundation, Sweden; Dementia Association, Sweden; Wenner-gren foundation; Strategic for UEF-BRAIN; JPND Project BIOMARKAPD; Goteborgs Lakaresallskap; Svenska Lakaresallskapet; Klinisk Biokemi i Norden; Carl-Bertil Laurells fond FX The study was supported by the Swedish Research Council (Project Nos. 14002, K2010-63P-21562-01-4, K2011-61X-20401-05-6), Stiftelsen Gamla Tjanarinnor, Magn. Bergvalls Stiftelse, Gun och Bertil Stohnes Stiftelse, the Swedish Brain Fund, the Alzheimer Foundation, Sweden, the Dementia Association, Sweden, Wenner-gren foundation, Strategic for UEF-BRAIN and the JPND Project BIOMARKAPD, Goteborgs Lakaresallskap, Svenska Lakaresallskapet, Klinisk Biokemi i Norden, Carl-Bertil Laurells fond. NR 26 TC 7 Z9 7 U1 1 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1535-1084 EI 1559-1174 J9 NEUROMOL MED JI Neuromol. Med. PD JUN PY 2014 VL 16 IS 2 BP 510 EP 516 DI 10.1007/s12017-014-8302-1 PG 7 WC Neurosciences SC Neurosciences & Neurology GA AH6EW UT WOS:000336224500022 PM 24740518 ER PT J AU Kemmerly, T Vuong, C Kaunitz, JD AF Kemmerly, Thomas Vuong, Carolyn Kaunitz, Jonathan D. TI A Novel Phosphorus Repletion Strategy in a Patient With Duodenal Perforation SO NUTRITION IN CLINICAL PRACTICE LA English DT Article DE adult; nutrition; phosphates; duodenum; drug shortage; parenteral formulas/compounding; GI access; phosphorus; fluids-electrolytes/acid-base; enteral access; parenteral nutrition; enema; life cycle; minerals/trace elements ID SEVERE HYPOPHOSPHATEMIA; ENEMA; HYPERPHOSPHATEMIA; NUTRITION AB We describe a case in which a patient receiving parenteral nutrition (PN) developed hypophosphatemia. Due to lack of availability of parenteral phosphate supplements, we chose to restore phosphate using diluted hypertonic sodium phosphate enemas. Due to the recent shortages of parenteral minerals and vitamins, such an alternate means of repletion is of increasing importance. Diluted hypertonic sodium phosphate enemas are inexpensive, easy to administer, and effective since phosphate is readily absorbed across the rectal mucosa. We hope that through this type of repletion, life-threatening hypophosphatemia among patients receiving PN can be avoided. C1 [Kemmerly, Thomas] Cedars Sinai Med Residency Program, Los Angeles, CA USA. [Vuong, Carolyn] WLAVA Med Ctr, Greater Los Angeles Vet Affairs Healthcare Syst, Dept Med, Los Angeles, CA USA. [Vuong, Carolyn] WLAVA Med Ctr, Greater Los Angeles Vet Affairs Healthcare Syst, Dept Pharm, Los Angeles, CA USA. [Kaunitz, Jonathan D.] UCLA Sch Med, Dept Med, Los Angeles, CA 90073 USA. [Kaunitz, Jonathan D.] UCLA Sch Med, Dept Surg, Los Angeles, CA 90073 USA. [Kaunitz, Jonathan D.] Brentwood Biomed Res Inst, Los Angeles, CA USA. RP Kaunitz, JD (reprint author), UCLA Sch Med, West Los Angeles VAMC, Bldg 114,Room 217E, Los Angeles, CA 90073 USA. EM jake@ucla.edu FU NIDDK NIH HHS [R01 DK054221] NR 17 TC 1 Z9 1 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0884-5336 EI 1941-2452 J9 NUTR CLIN PRACT JI Nutr. Clin. Pract. PD JUN PY 2014 VL 29 IS 3 BP 402 EP 405 DI 10.1177/0884533614529997 PG 4 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AH0FP UT WOS:000335794900020 PM 24743045 ER PT J AU Conhaim, RL Watson, KE Dovi, WF Bates, ML AF Conhaim, Robert L. Watson, Kal E. Dovi, William F. Bates, Melissa L. TI INHALED THROMBOLYTICS REDUCE LUNG MICROCLOT AND LEUKOCYTE INFILTRATION AFTER ACUTE BLOOD LOSS SO SHOCK LA English DT Article DE Acute lung injury; neutrophils; thromboembolism; shock lung; pulmonary circulation; fibrinolysis ID NEBULIZED ANTICOAGULANTS; INTERALVEOLAR PERFUSION; FIBRIN; RATS; INJURY; MICROVESSELS; COAGULOPATHY; INFLAMMATION; EDEMA AB We showed previously that a 30% blood loss in rats, without resuscitation, caused significant accumulation of microthrombi and leukocytes within the pulmonary circulation by 24 h. We hypothesized that the microthrombi formed spontaneously as a consequence of hemorrhage-induced stasis within the low-pressure pulmonary circuit and that the leukocytes were attracted to them. This suggested that elimination of the microthrombi, using an inhaled thrombolytic agent, could prevent the neutrophil sequestration after blood loss. To test this hypothesis, we removed 30% of the calculated blood volume from isoflurane-anesthetized, male Sprague-Dawley rats (350-500 g) over 5 min and allowed them to recover. Six hours later, we reanesthetized the rats and nebulized tissue plasminogen activator (80 or 320 mu g/kg), lactated Ringer's solution (LRS), or ipratropium bromide (i-bromide) into their lungs. We used i-bromide as a control after we discovered that nebulized LRS had thrombolytic properties. At 24 h, we removed and fixed the lungs and prepared sections for immunohistochemistry using antibodies against fibrinogen (microthrombi) and CD16 (leukocytes). Digital images of each section were obtained using a confocal microscope. Pixel counts of the images showed significantly less accumulation of microthrombi and leukocytes in lungs nebulized with tissue plasminogen activator or LRS than in nonnebulized lungs or in lungs nebulized with i-bromide (P 0.05). Lactated Ringer's solution becomes positively charged when nebulized (unlike i-bromide), suggesting that it eliminated microthrombi by fibrin depolymerization. We confirmed this using an in vitro assay. Our results demonstrate that lyses of microthrombi that accumulate in the lung after acute blood loss prevent subsequent leukocyte sequestration. C1 [Conhaim, Robert L.; Watson, Kal E.] Univ Wisconsin, Dept Surg, Sch Med & Publ Heath, Madison, WI USA. [Conhaim, Robert L.; Dovi, William F.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. [Bates, Melissa L.] Univ Wisconsin, Dept Pediat, Sch Med & Publ Heath, Madison, WI USA. RP Conhaim, RL (reprint author), H5-301-BX3236,600 Highland Ave, Madison, WI 53792 USA. EM rconhaim@wisc.edu FU Veterans Health Administration, Office of Research and Development, Department of Veterans Affairs, Biomedical Laboratory Research and Development Service FX This study was supported by the Veterans Health Administration, Office of Research and Development, Department of Veterans Affairs, Biomedical Laboratory Research and Development Service (R. L. C., principal investigator). NR 24 TC 1 Z9 1 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 IS 6 BP 528 EP 536 DI 10.1097/SHK.0000000000000149 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AH6CI UT WOS:000336217900010 PM 24837203 ER PT J AU Paruch, JL Merkow, RP Bentrem, DJ Ko, CY Posner, MC Cohen, ME Bilimoria, KY Weber, SM AF Paruch, Jennifer L. Merkow, Ryan P. Bentrem, David J. Ko, Clifford Y. Posner, Mitchell C. Cohen, Mark E. Bilimoria, Karl Y. Weber, Sharon M. TI Impact of Hepatectomy Surgical Complexity on Outcomes and Hospital Quality Rankings SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article ID RISK-ADJUSTMENT; IMPROVEMENT PROGRAM; LIVER RESECTION; NSQIP; SURGERY; MODELS AB There is substantial variation in the surgical complexity of hepatectomy. Currently, the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) risk adjusts for hospital quality comparisons using only the primary procedure code. Our objectives were to (1) assess the association between secondary procedures and complications; (2) assess model performance with inclusion of surgical complexity adjustment; and (3) examine whether secondary procedures affect hospital quality rankings. Using ACS NSQIP (2007-2012), patients undergoing hepatectomy were identified. Secondary procedure codes and total work relative value units (RVUs) were used to approximate procedural complexity. The effect of procedural complexity variables on outcomes and hospital quality rankings were examined using hierarchical models. Among 11,826 patients who underwent hepatectomy at 261 hospitals, 32.8 % underwent at least one secondary procedure. Serious morbidity occurred in 18.0 % of patients. Seven of nine secondary procedures were significantly associated with death or serious morbidity on multivariable analysis. Model performance improved when secondary procedure categories were included, and secondary procedure categories outperformed total RVUs. The C-statistic for death or serious morbidity was 0.689 in the standard NSQIP model, 0.703 when total RVU was included, and 0.718 when secondary procedure categories were included. Of the 26 hospitals that were poor performers for death or serious morbidity using the standard ACS NSQIP model, three became average performers when secondary procedure categories were included in the model. Secondary procedures are associated with an increased risk of postoperative complications. Inclusion of secondary procedure code categories in research and risk prediction models should be considered for hepatectomy. C1 [Paruch, Jennifer L.; Merkow, Ryan P.; Ko, Clifford Y.; Cohen, Mark E.; Bilimoria, Karl Y.] Amer Coll Surg, Div Res & Optimal Patient Care, Chicago, IL 60611 USA. [Paruch, Jennifer L.; Merkow, Ryan P.; Posner, Mitchell C.] Univ Chicago, Dept Surg, Pritzker Sch Med, Chicago, IL 60637 USA. [Merkow, Ryan P.; Bentrem, David J.; Bilimoria, Karl Y.] Northwestern Univ, Dept Surg, Surg Outcomes & Qual Improvement Ctr, Feinberg Sch Med, Chicago, IL 60611 USA. [Merkow, Ryan P.; Bentrem, David J.; Bilimoria, Karl Y.] Northwestern Univ, Northwestern Inst Comparat Effectiveness Res Onco, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. [Bentrem, David J.] Jesse Brown VA Med Ctr, Dept Surg, Chicago, IL USA. [Ko, Clifford Y.] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90024 USA. [Ko, Clifford Y.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Weber, Sharon M.] Univ Wisconsin, Dept Surg, Sch Med & Publ Hlth, Madison, WI USA. RP Paruch, JL (reprint author), Amer Coll Surg, Div Res & Optimal Patient Care, Chicago, IL 60611 USA. EM jlparuch@gmail.com FU American Cancer Society; National Comprehensive Cancer Network FX This work was supported in part by the American Cancer Society (Drs. Merkow and Bilimoria) and the National Comprehensive Cancer Network (Dr. Bilimoria). NR 20 TC 8 Z9 8 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 EI 1534-4681 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD JUN PY 2014 VL 21 IS 6 BP 1773 EP 1780 DI 10.1245/s10434-014-3500-5 PG 8 WC Oncology; Surgery SC Oncology; Surgery GA AG9GH UT WOS:000335726900005 PM 24558060 ER PT J AU Baldwin, MR Reid, MC Westlake, AA Rowe, JW Granieri, EC Wunsch, H Dam, TT Rabinowitz, D Goldstein, NE Maurer, MS Lederer, DJ AF Baldwin, Matthew R. Reid, M. Cary Westlake, Amanda A. Rowe, John W. Granieri, Evelyn C. Wunsch, Hannah Thuy-Tien Dam Rabinowitz, Daniel Goldstein, Nathan E. Maurer, Mathew S. Lederer, David J. TI The feasibility of measuring frailty to predict disability and mortality in older medical intensive care unit survivors SO JOURNAL OF CRITICAL CARE LA English DT Article DE Aged; Critically Ill; Frailty; Disability; Mortality ID PROLONGED MECHANICAL VENTILATION; CHRONIC CRITICAL ILLNESS; ACQUIRED WEAKNESS; FUNCTIONAL STATUS; RANDOMIZED-TRIAL; MUSCLE STRENGTH; SKELETAL-MUSCLE; CRITICALLY-ILL; ADULTS; OUTCOMES AB Purpose: To determine whether frailty can be measured within 4 days prior to hospital discharge in older intensive care unit (ICU) survivors of respiratory failure and whether it is associated with post-discharge disability and mortality. Materials and Methods: We performed a single-center prospective cohort study of 22 medical ICU survivors age 65 years or older who had received noninvasive or invasive mechanical ventilation for at least 24 hours. Frailty was defined as a score of >= 3 using Fried's 5-point scale. We measured disability with the Katz Activities of Daily Living. We estimated unadjusted associations between Fried's frailty score and incident disability at 1-month and 6-month mortality using Cox proportional hazard models. Results: The mean (SD) age was 77 (9) years, mean Acute Physiology and Chronic Health Evaluation II score was 27 (9.7), mean frailty score was 3.4 (1.3), and 18 (82%) were frail. Nine subjects (41%) died within 6 months, and all were frail. Each 1-point increase in frailty score was associated with a 90% increased rate of incident disability at 1-month (rate ratio: 1.9, 95% CI 0.7-4.9) and a threefold increase in 6-month mortality (rate ratio: 3.0, 95% CI 1.4-6.3). Conclusions: Frailty can be measured in older ICU survivors near hospital discharge and is associated with 6-month mortality in unadjusted analysis. Larger studies to determine if frailty independently predicts outcomes are warranted. (C) 2014 Elsevier Inc. All rights reserved. C1 [Baldwin, Matthew R.; Westlake, Amanda A.; Lederer, David J.] Columbia Univ, Coll Phys & Surg, Div Pulm & Crit Care, New York, NY USA. [Reid, M. Cary] Weill Cornell Med Ctr, Div Geriatr, New York, NY USA. [Rowe, John W.] Columbia Univ, Mailman Sch Publ Hlth, Dept Hlth Policy, New York, NY USA. [Granieri, Evelyn C.] Columbia Univ, Coll Phys & Surg, Div Geriatr Med & Aging, New York, NY USA. [Wunsch, Hannah; Thuy-Tien Dam; Lederer, David J.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. [Wunsch, Hannah] Columbia Univ, Coll Phys & Surg, Dept Anesthesiol, New York, NY USA. [Rabinowitz, Daniel] Columbia Univ, Dept Stat, New York, NY 10027 USA. [Goldstein, Nathan E.] Mt Sinai Sch Med, Div Geriatr & Palliat Med, New York, NY USA. [Goldstein, Nathan E.] James J Peters VA Med Ctr, Clin Ctr, New York, NY USA. [Maurer, Mathew S.] Columbia Univ, Coll Phys & Surg, Div Cardiol, New York, NY USA. RP Baldwin, MR (reprint author), 622 W 168th St,PH-8,Room 101, New York, NY 10032 USA. EM mrb45@columbia.edu OI Reid, Cary/0000-0001-8117-662X; Lederer, David/0000-0001-5258-0228 FU National Institute on Aging (NIA) [3P30AG022845-078] FX The authors of this manuscript have no conflicts of interest to disclose as described by the Journal of Critical Care. This study was funded by a sub-contract pilot grant from grant 3P30AG022845-078 from the National Institute on Aging (NIA), and the NIA had no role in the study design, analysis, or manuscript approval. NR 51 TC 11 Z9 11 U1 5 U2 13 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 EI 1557-8615 J9 J CRIT CARE JI J. Crit. Care PD JUN PY 2014 VL 29 IS 3 BP 401 EP 408 DI 10.1016/j.jcrc.2013.12.019 PG 8 WC Critical Care Medicine SC General & Internal Medicine GA AH0OA UT WOS:000335818300016 PM 24559575 ER PT J AU Schilero, GJ Radulovic, M Wecht, JM Spungen, AM Bauman, WA Lesser, M AF Schilero, Gregory J. Radulovic, Miroslav Wecht, Jill M. Spungen, Ann M. Bauman, William A. Lesser, Marvin TI A Center's Experience: Pulmonary Function in Spinal Cord Injury SO LUNG LA English DT Review DE Spinal cord injury; Tetraplegia; Pulmonary function; Respiratory muscle function; Nonspecific airway hyperreactivity; Airway inflammation; Obstructive sleep apnea ID GASTROESOPHAGEAL-REFLUX DISEASE; OBSTRUCTIVE SLEEP-APNEA; AIR-FLOW OBSTRUCTION; RIB CAGE MOTION; BRONCHIAL HYPERRESPONSIVENESS; INDUCED BRONCHOCONSTRICTION; RESPIRATORY MECHANICS; TETRAPLEGIC SUBJECTS; IPRATROPIUM BROMIDE; VITAL CAPACITY AB Traumatic spinal cord injury (SCI) is associated with significant psychological and physical challenges. A multidisciplinary approach to management is essential to ensure recovery during the acute phase, and comprehensive rehabilitative strategies are necessary to foster independence and quality of life throughout the chronic phase of injury. Complications that beset these individuals are often a unique consequence of SCI, and knowledge of the effects of SCI upon organ systems is essential for appropriate management. According to the National SCI Statistical Center (NSCISC), as of 2010 there were an estimated 265,000 persons living with SCI in the United States, with approximately 12,000 incidence cases annually. Although life expectancy for newly injured individuals with SCI is markedly reduced, persons with chronic SCI are expected to live about as long as individuals without SCI; however, longevity varies inversely with level of injury. Since 2005, 56 % of persons with SCI are tetraplegic, and due to paralysis of respiratory muscles, these individuals may be especially prone to pulmonary complications, which remain a major cause of mortality among persons with chronic SCI. We at the VA Rehabilitation Research and Development Center of Excellence for the Medical Consequences of SCI at the James J. Peters VA Medical Center have devoted more than 25 years to the study of secondary medical conditions that complicate SCI. Herein, we review pulmonary research at the Center, both our past and future endeavors, which form an integral part of our multidisciplinary approach toward achieving a greater understanding of and improving care for veterans with SCI. C1 [Schilero, Gregory J.; Radulovic, Miroslav; Wecht, Jill M.; Spungen, Ann M.; Bauman, William A.; Lesser, Marvin] James J Peters VA Med Ctr, Bronx, NY 10468 USA. [Schilero, Gregory J.; Radulovic, Miroslav; Wecht, Jill M.; Spungen, Ann M.; Bauman, William A.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. RP Schilero, GJ (reprint author), James J Peters VA Med Ctr, Bronx, NY 10468 USA. EM greg.schilero@va.gov NR 63 TC 2 Z9 2 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0341-2040 EI 1432-1750 J9 LUNG JI Lung PD JUN PY 2014 VL 192 IS 3 BP 339 EP 346 DI 10.1007/s00408-014-9575-8 PG 8 WC Respiratory System SC Respiratory System GA AH3LU UT WOS:000336025900001 PM 24723067 ER PT J AU Tang, HY Sayers, SL Weissinger, G Riegel, B AF Tang, Hsin-Yi (Jean) Sayers, Steven L. Weissinger, Guy Riegel, Barbara TI The Role of Depression in Medication Adherence Among Heart Failure Patients SO CLINICAL NURSING RESEARCH LA English DT Article DE heart failure; depression; major depressive disorders; medication adherence ID SELF-REPORT; NONADHERENCE; DISEASE; ANXIETY; RECOMMENDATIONS; NONCOMPLIANCE; INTERVENTION; METAANALYSIS; ASSOCIATION; PREVALENCE AB The purpose of the study was to explore the association between depression and medication adherence in heart failure (HF) patients. Studies have shown that people with depression are likely to be nonadherent to their prescribed medication treatment. But other studies suggest that nonadherence may be overestimated by people with depression. A total of 244 adults with Stage C HF completed the study. Self-reported medication adherence was obtained using the Basel Assessment of Adherence Scale (BAAS); objective data on medication adherence were collected using the electronic Medication Event Monitoring System (MEMS). Depression was measured via self-report with the Patient Health Questionnaire (PHQ-9). There was a significant difference between depressed and nondepressed participants in self-reported medication nonadherence (p = .008), but not in objectively measured medication nonadherence (p = .72). The depressed sample was 2.3 times more likely to self-report poor medication adherence than those who were nondepressed (p = .006). C1 [Tang, Hsin-Yi (Jean)] Seattle Univ, Coll Nursing, Seattle, WA 98125 USA. [Sayers, Steven L.] Vet Affairs Med Ctr, Philadelphia, PA USA. [Weissinger, Guy] Univ Penn, Perelman Sch Med, Aaron T Beck Ctr Psychopathol Res, Philadelphia, PA 19104 USA. [Riegel, Barbara] Univ Penn, Sch Nursing, Biobehav Res Ctr, Philadelphia, PA 19104 USA. RP Tang, HY (reprint author), Seattle Univ, Coll Nursing, 901 12th Ave POB 222000, Seattle, WA 98125 USA. EM jeantang@u.washington.edu FU National Heart, Lung & Blood Institute [RO1 HL084394-01A1]; Philadelphia Veterans Affairs Medical Center, VISN 4 Mental Illness Research, Education, and Clinical Center (MIREC); Hope Heart Institute, Seattle, Washington FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded by (a) National Heart, Lung & Blood Institute (RO1 HL084394-01A1), (b) Philadelphia Veterans Affairs Medical Center, VISN 4 Mental Illness Research, Education, and Clinical Center (MIREC) [the opinions expressed herein do not represent the official policy of the Department of Veterans Affairs], and (c) Hope Heart Institute, Seattle, Washington. NR 40 TC 5 Z9 5 U1 2 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1054-7738 EI 1552-3799 J9 CLIN NURS RES JI Clin. Nurs. Res. PD JUN PY 2014 VL 23 IS 3 BP 231 EP 244 DI 10.1177/1054773813481801 PG 14 WC Nursing SC Nursing GA AG7EF UT WOS:000335580200001 PM 23548500 ER PT J AU Shores, MM Matsumoto, AM AF Shores, Molly M. Matsumoto, Alvin M. TI Testosterone, aging and survival: biomarker or deficiency SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY LA English DT Review DE aging; androgens; biomarker; mortality; testosterone ID LOW SERUM TESTOSTERONE; ALL-CAUSE MORTALITY; CORONARY-HEART-DISEASE; PLACEBO-CONTROLLED TRIALS; ENDOGENOUS SEX-HORMONES; POPULATION-BASED COHORT; LIFE-STYLE FACTORS; QUALITY-OF-LIFE; OLDER MEN; CARDIOVASCULAR-DISEASE AB Purpose of reviewThe purpose of this study is to review recent studies that examined the association of endogenous and exogenous testosterone and mortality in older men.Recent findingsOver the past several years, there has been a steep rise in testosterone prescriptions. The increased use of testosterone occurred in the context of several studies that reported an association between low serum testosterone and increased cardiovascular events and mortality. In contrast, recent studies have reported an association between testosterone treatment and adverse events. A testosterone treatment trial of mobility-impaired elderly men with prevalent cardiovascular disease was stopped due to increased cardiovascular events in the T-treated men and a meta-analysis reported increased cardiovascular events in T-treated men. In two recent large observational studies, testosterone treatment was associated with an increased risk for serious adverse cardiovascular events.SummaryLow testosterone is associated with mortality in multiple cohort studies; however, it is unclear if this is a causal association or due to low testosterone being a biomarker of poor health. Given recent reports of adverse outcomes associated with testosterone treatment, a conservative use of testosterone is warranted in men with cardiovascular disease who may be at greater risk for adverse outcomes. C1 [Shores, Molly M.] VA Puget Sound Healthcare Syst, Seattle, WA 98108 USA. [Shores, Molly M.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Matsumoto, Alvin M.] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA USA. [Matsumoto, Alvin M.] GRECC, Seattle, WA USA. RP Shores, MM (reprint author), VA Puget Sound Healthcare Syst, 1660 S Columbian Way,S-116A, Seattle, WA 98108 USA. EM molly.shores@va.gov FU VA Research Service; VA Geriatric Research Education and Clinical Center (GRECC); 1R01 AG042934-01; AbbVie; GSK Pharmaceuticals; Advisory Board for Abbott; Advisory Board for Endo; Forendo Pharmaceuticals; UpToDate. FX The research was supported by the VA Research Service, the VA Geriatric Research Education and Clinical Center (GRECC) and by 1R01 AG042934-01.; Disclosure summary: Dr Matsumoto has the following disclosures to make - Research support from AbbVie and GSK Pharmaceuticals; Advisory Board for Abbott, Endo, and Forendo Pharmaceuticals; and Editor for UpToDate. NR 80 TC 4 Z9 4 U1 0 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1752-296X EI 1752-2978 J9 CURR OPIN ENDOCRINOL JI Curr. Opin. Endocrinol. Diabetes Obes. PD JUN PY 2014 VL 21 IS 3 BP 209 EP 216 DI 10.1097/MED.0000000000000057 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AG5FS UT WOS:000335445500009 PM 24722173 ER PT J AU Punnen, S Freedland, SJ Presti, JC Aronson, WJ Terris, MK Kane, CJ Amling, CL Carroll, PR Cooperberg, MR AF Punnen, Sanoj Freedland, Stephen J. Presti, Joseph C., Jr. Aronson, William J. Terris, Martha K. Kane, Christopher J. Amling, Christopher L. Carroll, Peter R. Cooperberg, Matthew R. TI Multi-institutional Validation of the CAPRA-S Score to Predict Disease Recurrence and Mortality After Radical Prostatectomy SO EUROPEAN UROLOGY LA English DT Article DE Nomogram; Outcomes; Prostate cancer; Radical prostatectomy ID RANDOMIZED CLINICAL-TRIAL; UNIVERSITY-OF-CALIFORNIA; RISK-ASSESSMENT SCORE; BIOCHEMICAL RECURRENCE; ADJUVANT RADIOTHERAPY; EXTERNAL VALIDATION; CANCER RECURRENCE; SAN-FRANCISCO; MODELS; SURVIVAL AB Background: The University of California, San Francisco, Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score uses pathologic data from radical prostatectomy (RP) to predict prostate cancer recurrence and mortality. However, this clinical tool has never been validated externally. Objective: To validate CAPRA-S in a large, multi-institutional, external database. Design, setting, and participants: The Shared Equal Access Regional Cancer Hospital (SEARCH) database consists of 2892 men who underwent RP from 2001 to 2011. With a median follow-up of 58 mo, 2670men(92%) had complete data to calculate a CAPRA-S score. Intervention: RP. Outcome measurements and statistical analysis: The main outcome was biochemical recurrence. Performance of CAPRA-S in detecting recurrence was assessed and compared with a validated postoperative nomogram by concordance index (c-index), calibration plots, and decision curve analysis. Prediction of cancer-specific mortality was assessed by Kaplan-Meier analysis and the c-index. Results and limitations: The mean age was 62 yr (standard deviation: 6.3), and 34.3% of men had recurrence. The 5-yr progression-free probability for those patients with a CAPRA-S score of 0-2, 3-5, and 6-10 (defining low, intermediate, and high risk) was 72%, 39%, and 17%, respectively. The CAPRA-S c-index was 0.73 in this validation set, compared with a c-index of 0.72 for the Stephenson nomogram. Although CAPRA-S was optimistic in predicting the likelihood of being free of recurrence at 5 yr, it outperformed the Stephenson nomogram on both calibration plots and decision curve analysis. The cindex for predicting cancer-specific mortality was 0.85, with the caveat that this number is based on only 61 events. Conclusions: In this external validation, the CAPRA-S score predicted recurrence and mortality after RP with a c-index > 0.70. The score is an effective prognostic tool that may aid in determining the need for adjuvant therapy. (C) 2013 European Association of Urology. Published by Elsevier B. V. All rights reserved. C1 [Punnen, Sanoj; Carroll, Peter R.; Cooperberg, Matthew R.] Univ Calif San Francisco, Dept Urol, Ctr Comprehens Canc, San Francisco, CA 94143 USA. [Freedland, Stephen J.] Duke Univ, Dept Surg, Div Urol, Durham, NC USA. [Freedland, Stephen J.] Durham Vet Adm Med Ctr, Urol Sect, Durham, NC USA. [Presti, Joseph C., Jr.] Stanford Univ, Sch Med, Dept Urol, Stanford, CA 94305 USA. [Presti, Joseph C., Jr.] Vet Adm Med Ctr, Dept Surg, Urol Sect, Palo Alto, CA 94304 USA. [Aronson, William J.] Vet Adm Greater Los Angeles Healthcare Syst, Urol Sect, Dept Surg, Los Angeles, CA USA. [Aronson, William J.] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA USA. [Terris, Martha K.] Vet Adm Med Ctr, Dept Surg, Urol Sect, Augusta, GA 30904 USA. [Terris, Martha K.] Med Coll Georgia, Dept Surg, Augusta, GA 30912 USA. [Kane, Christopher J.] Univ Calif San Diego, Dept Urol, San Diego, CA 92103 USA. [Amling, Christopher L.] Oregon Hlth & Sci Univ, Dept Urol, Portland, OR USA. [Cooperberg, Matthew R.] Vet Adm Med Ctr, Dept Surg, Urol Sect, San Francisco, CA 94121 USA. RP Cooperberg, MR (reprint author), Univ Calif San Francisco, Dept Urol, 1600 Divisadero St,Box 1695, San Francisco, CA 94143 USA. EM mcooperberg@urology.ucsf.edu OI Terris, Martha/0000-0002-3843-7270 FU US Department of Veterans Affairs; US Department of Defense; Prostate Cancer Research Program; NIH [R01CA100938]; NIH Specialized Programs of Research Excellence [P50 CA92131-01A1]; Georgia Cancer Coalition; American Urological Association Foundation/Astellas Rising Star in Urology Award FX Funding for the collection and management of the data was from the US Department of Veterans Affairs, the US Department of Defense, Prostate Cancer Research Program (C.J.K., S.J.F), NIH R01CA100938 (W.J.A), NIH Specialized Programs of Research Excellence Grant P50 CA92131-01A1 (W.J.A), Georgia Cancer Coalition (M.K.T), and the American Urological Association Foundation/Astellas Rising Star in Urology Award (S.J.E). Views and opinions of and endorsements by the authors do not reflect thsoe of the US Army or the Department of Defense. NR 26 TC 40 Z9 41 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0302-2838 EI 1873-7560 J9 EUR UROL JI Eur. Urol. PD JUN PY 2014 VL 65 IS 6 BP 1171 EP 1177 DI 10.1016/j.eururo.2013.03.058 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA AG4JV UT WOS:000335386700044 PM 23587869 ER PT J AU Byers, AL Yaffe, K AF Byers, Amy L. Yaffe, Kristine TI Depression and dementias among military veterans SO ALZHEIMERS & DEMENTIA LA English DT Article DE Dementia; Alzheimer's disease; Cognitive impairment; Depression; Posttraumatic stress disorder; Traumatic brain injury; Older veterans ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; MILD COGNITIVE IMPAIRMENT; LATE-LIFE DEPRESSION; WHITE-MATTER HYPERINTENSITIES; CARDIOVASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; HIPPOCAMPAL VOLUME; MAJOR DEPRESSION; GERIATRIC DEPRESSION AB Depression is very common throughout the course of veterans' lives, and dementia is common in late life. Previous studies suggest an association between depression and dementia in military veterans. The most likely biologic mechanisms that may link depression and dementia among military veterans include vascular disease, changes in glucocorticoid steroids and hippocampal atrophy, deposition of beta-amyloid plaques, inflammatory changes, and alterations of nerve growth factors. In addition, military veterans often have depression comorbid with posttraumatic stress disorder or traumatic brain injury. Therefore, in military veterans, these hypothesized biologic pathways going from depression to dementia are more than likely influenced by trauma-related processes. Treatment strategies for depression, posttraumatic stress disorder, or traumatic brain injury could alter these pathways and as a result decrease the risk for dementia. Given the projected increase of dementia, as well as the projected increase in the older segment of the veteran population, in the future, it is critically important that we understand whether treatment for depression alone or combined with other regimens improves cognition. In this review, we summarize the principal mechanisms of this relationship and discuss treatment implications in military veterans. (C) 2014 The Alzheimer's Association. All rights reserved. C1 [Byers, Amy L.; Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94121 USA. [Byers, Amy L.; Yaffe, Kristine] San Francisco VA Med Ctr, San Francisco, CA USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. RP Byers, AL (reprint author), Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94121 USA. EM Amy.Byers@ucsf.edu FU United States Army Medical Research and Materiel Command FX Publication of this article was supported by the United States Army Medical Research and Materiel Command. NR 114 TC 5 Z9 6 U1 5 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 EI 1552-5279 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUN PY 2014 VL 10 IS 3 SU 1 BP S166 EP S173 DI 10.1016/j.jalz.2014.04.007 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA CP8GM UT WOS:000360130700011 PM 24924668 ER PT J AU Durazzo, TC Mattsson, N Weiner, MW AF Durazzo, Timothy C. Mattsson, Niklas Weiner, Michael W. CA Alzheimer's Dis Neuroimaging TI Smoking and increased Alzheimer's disease risk: A review of potential mechanisms SO ALZHEIMERS & DEMENTIA LA English DT Article DE Alzheimer's disease; Cigarette smoking; Tobacco; Risk; Amyloid; Tau; Military; Oxidative stress; US Armed Services ID CHRONIC CIGARETTE-SMOKING; MILD COGNITIVE IMPAIRMENT; ALCOHOL-DEPENDENT INDIVIDUALS; POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL AMYLOID ANGIOPATHY; NICOTINIC ACETYLCHOLINE-RECEPTOR; TRAUMATIC BRAIN-INJURY; PITTSBURGH COMPOUND-B; FREE-RADICAL DAMAGE; STRESS IN-VIVO AB Background: Cigarette smoking has been linked with both increased and decreased risk for Alzheimer's disease (AD). This is relevant for the US military because the prevalence of smoking in the military is approximately 11% higher than in civilians. Methods: A systematic review of published studies on the association between smoking and increased risk for AD and preclinical and human literature on the relationships between smoking, nicotine exposure, and AD-related neuropathology was conducted. Original data from comparisons of smoking and never-smoking cognitively normal elders on in vivo amyloid imaging are also presented. Results: Overall, literature indicates that former/active smoking is related to a significantly increased risk for AD. Cigarette smoke/smoking is associated with AD neuropathology in preclinical models and humans. Smoking-related cerebral oxidative stress is a potential mechanism promoting AD pathology and increased risk for AD. Conclusions: A reduction in the incidence of smoking will likely reduce the future prevalence of AD. (C) 2014 The Alzheimer's Association. All rights reserved. C1 [Durazzo, Timothy C.; Mattsson, Niklas; Weiner, Michael W.] San Francisco VA Med Ctr, CIND, San Francisco, CA 94121 USA. [Durazzo, Timothy C.; Mattsson, Niklas; Weiner, Michael W.] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA. [Mattsson, Niklas] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Clin Neurochem Lab, Molndal, Sweden. [Weiner, Michael W.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. RP Durazzo, TC (reprint author), San Francisco VA Med Ctr, CIND, San Francisco, CA 94121 USA. EM timothy.durazzo@ucsf.edu FU National Institutes of Health [NIH DA24136, P30 AG010129, K01 AG030514, R01 AG010897, R01 AG012435]; ADNI; National Institute on Aging [U01 AG024904]; National Institute of Biomedical Imaging and Bioengineering; Dana Foundation FX T.C.D. was responsible for the concept and design of the review, completed all statistical analyses on the original data presented, and wrote the original and revised versions of the manuscript. N.M. and M.W.W. were involved in manuscript editing, data interpretation, and manuscript draft revisions. T.C.D. had full access to all the original data presented study and takes responsibility for the integrity of the data and the accuracy of the data analyses. This work was supported by the National Institutes of Health (NIH DA24136 to T.C.D.) and by the use of resources and facilities at the San Francisco Veterans Administration Medical Center. Florbetapir data collection and sharing for this project was funded by ADNI. ADNI is funded by the National Institute on Aging (U01 AG024904), the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Abbott; AstraZeneca AB; Bayer Schering Pharma AG; Bristol-Myers Squibb; Eisai Global Clinical Development; Elan Corporation; Genentech; GE Healthcare; GlaxoSmithKline; Innogenetics; Johnson and Johnson; Eli Lilly and Co.; Medpace, Inc.; Merck and Co., Inc.; Novartis AG; Pfizer Inc; F. Hoffman-La Roche; Schering-Plough; Synarc, Inc.; and Wyeth, as well as nonprofit partners such as the Alzheimer's Association and Alzheimer Drug Discovery Foundation, with participation from the U.S. Food and Drug Administration. Private sector contributions to ADNI are facilitated by the Foundation for the National Institutes of Health (www.fnih.org; http://www.fnih.org; http://www.fnih.org; http://www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University Southern California. This research was also supported by National Institutes of Health grants P30 AG010129, K01 AG030514, R01 AG010897, and R01 AG012435, and The Dana Foundation and by resources by resources and the use of facilities at the San Francisco Veterans Administration Medical Center, San Francisco, CA. The aforementioned funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Original data used in preparation of this article were obtained from the ADNI database (www.loni.usc.edu/ADNI). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Authorship _List. pdf NR 260 TC 39 Z9 41 U1 5 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 EI 1552-5279 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUN PY 2014 VL 10 IS 3 SU 1 BP S122 EP S145 DI 10.1016/j.jalz.2014.04.009 PG 24 WC Clinical Neurology SC Neurosciences & Neurology GA CP8GM UT WOS:000360130700008 PM 24924665 ER PT J AU Meziab, O Kirby, KA Williams, B Yaffe, K Byers, AL Barnes, DE AF Meziab, Omar Kirby, Katharine A. Williams, Brie Yaffe, Kristine Byers, Amy L. Barnes, Deborah E. TI Prisoner of war status, posttraumatic stress disorder, and dementia in older veterans SO ALZHEIMERS & DEMENTIA LA English DT Article DE Dementia; Risk factors; Veterans; Aged; POW; Posttraumatic stress disorder ID FOLLOW-UP; PLASMA-CORTISOL; HUMAN-MEMORY; FAR-EAST; RISK; DISABILITY; DISEASE; HEALTH; MALNUTRITION; PREVALENCE AB Background: It is not known whether prisoners of war (POWs) are more likely to develop dementia independently of the effects of posttraumatic stress disorder (PTSD). Methods: We performed a retrospective cohort study in 182,879 U.S. veterans age 55 years and older, and examined associations between POW status and PTSD at baseline (October 1, 2000-September 30, 2003), and incident dementia during follow-up (October 1, 2003-September 30, 2012). Results: A total of 484 veterans (0.3%) reported being POWs, of whom 150 (31.0%) also had PTSD. After adjusting for demographics, medical and psychiatric comorbidities, period of service, and the competing risk of death, the risk of dementia was increased in veterans who were POWs only (hazard ratio [HR], 1.61; 95% confidence interval [CI], 1.30-1.98) or had PTSD only (HR, 1.52; 95% CI, 1.41-1.64) and was greatest in veterans who were POWs and also had PTSD (HR, 2.24; 95% CI, 1.72-2.92). Conclusions: POW status and PTSD increase risk of dementia in an independent, additive manner in older veterans. (C) 2014 Published by Elsevier Inc. on behalf of The Alzheimer's Association. C1 [Meziab, Omar] Univ Arizona, Sch Med, Tucson, AZ USA. [Kirby, Katharine A.; Williams, Brie] Univ Calif San Francisco, Dept Med, Div Geriatr, San Francisco, CA USA. [Kirby, Katharine A.; Williams, Brie; Yaffe, Kristine; Byers, Amy L.; Barnes, Deborah E.] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Yaffe, Kristine; Byers, Amy L.; Barnes, Deborah E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Yaffe, Kristine; Barnes, Deborah E.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. RP Barnes, DE (reprint author), San Francisco VA Med Ctr, San Francisco, CA 94121 USA. EM Deborah.barnes@ucsf.edu FU Department of Defense/NCIRE (The Veterans Health Research Institute) [W81XWH-11-2-0189, 1610, 1614, W81XWH-12-1-0581]; National Institutes of Health [K24 AG031155] FX This study was supported by the Department of Defense/NCIRE (The Veterans Health Research Institute) (Barnes: W81XWH-11-2-0189, project 1610; Byers: W81XWH-11-2-0189, project 1614; Yaffe: W81XWH-12-1-0581) and the National Institutes of Health (Yaffe: K24 AG031155). The views expressed do not necessarily reflect those of the U.S. government. NR 40 TC 10 Z9 10 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 EI 1552-5279 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUN PY 2014 VL 10 IS 3 SU 1 BP S236 EP S241 DI 10.1016/j.jalz.2014.04.004 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA CP8GM UT WOS:000360130700017 PM 24924674 ER PT J AU Tanner, CM Goldman, SM Ross, GW Grate, SJ AF Tanner, Caroline M. Goldman, Samuel M. Ross, G. Webster Grate, Stephen J. TI The disease intersection of susceptibility and exposure: Chemical exposures and neurodegenerative disease risk SO ALZHEIMERS & DEMENTIA LA English DT Article DE Neurodegeneration; Parkinson's disease; Alzheimer's disease; Motor neuron disease; Military; Risk factors; Pesticides; Traumatic brain injury; Solvents; Gene-environment interaction ID AMYOTROPHIC-LATERAL-SCLEROSIS; MOTOR-NEURON-DISEASE; METHYLAMINO-L-ALANINE; GULF-WAR VETERANS; STRIATAL DOPAMINE TRANSPORTER; CUMULATIVE LEAD-EXPOSURE; PERIOD-COHORT ANALYSIS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; POLYCHLORINATED-BIPHENYLS AB Alzheimer's disease, Parkinson's disease, and motor neuron disease, the most common of the late-life neurodegenerative disorders, are in most cases thought to have complex etiologies. Common features among these disorders include insidious onset, pathological findings of protein aggregates and selected neuronal degeneration, and resulting characteristic clinical syndromes. The number of elders in the United States, including aging veterans, is increasing. Investigation of causes and preventive interventions for neurodegenerative disorders is increasingly relevant. Recent epidemiological and laboratory studies suggest that exposures years or decades before diagnosis can trigger the processes that ultimately result in a neurodegenerative disease. If this is correct, preventive measures may be needed in midlife or earlier. This article will focus on putative risk factors relevant to military service. Published by Elsevier Inc. on behalf of The Alzheimer's Association. C1 [Tanner, Caroline M.; Goldman, Samuel M.] San Francisco VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, San Francisco, CA 94121 USA. [Tanner, Caroline M.; Goldman, Samuel M.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Tanner, Caroline M.; Goldman, Samuel M.] Parkinsons Inst, Sunnyvale, CA USA. [Ross, G. Webster] Vet Affairs Pacific Isl Hlth Care Syst, Honolulu, HI USA. [Grate, Stephen J.] MSAMRMC, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Tanner, CM (reprint author), San Francisco VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, San Francisco, CA 94121 USA. EM caroline.tanner@ucsf.edu FU United States Army Medical Research and Materiel Command FX Publication of this article was supported by the United States Army Medical Research and Materiel Command. NR 176 TC 14 Z9 14 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 EI 1552-5279 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUN PY 2014 VL 10 IS 3 SU 1 BP S213 EP S225 DI 10.1016/j.jalz.2014.04.014 PG 13 WC Clinical Neurology SC Neurosciences & Neurology GA CP8GM UT WOS:000360130700015 PM 24924672 ER PT J AU Yaffe, K Hoang, TD Byers, AL Barnes, DE Friedl, KE AF Yaffe, Kristine Hoang, Tina D. Byers, Amy L. Barnes, Deborah E. Friedl, Karl E. TI Lifestyle and health-related risk factors and risk of cognitive aging among older veterans SO ALZHEIMERS & DEMENTIA LA English DT Article DE Veterans; Dementia; Cognitive aging; Lifestyle behaviors; Health-related risk factors ID POSTTRAUMATIC-STRESS-DISORDER; OBSTRUCTIVE SLEEP-APNEA; CEREBRAL WHITE-MATTER; US ARMY SOLDIERS; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; BLOOD-PRESSURE; SOCIAL NETWORK; MENTAL-HEALTH AB Lifestyle and health-related factors are critical components of the risk for cognitive aging among veterans. Because dementia has a prolonged prodromal phase, understanding effects across the life course could help focus the timing and duration of prevention targets. This perspective may be especially relevant for veterans and health behaviors. Military service may promote development and maintenance of healthy lifestyle behaviors, but the period directly after active duty has ended could be an important transition stage and opportunity to address some important risk factors. Targeting multiple pathways in one intervention may maximize efficiency and benefits for veterans. A recent review of modifiable risk factors for Alzheimer's disease estimated that a 25% reduction of a combination of seven modifiable risk factors including diabetes, hypertension, obesity, depression, physical inactivity, smoking, and education/cognitive inactivity could prevent up to 3 million cases worldwide and 492,000 cases in the United States. Lifestyle interventions to address cardiovascular health in veterans may serve as useful models with both physical and cognitive activity components, dietary intervention, and vascular risk factor management. Although the evidence is accumulating for lifestyle and health-related risk factors as well as military risk factors, more studies are needed to characterize these factors in veterans and to examine the potential interactions between them. Published by Elsevier Inc. on behalf of The Alzheimer's Association. C1 [Yaffe, Kristine; Byers, Amy L.; Barnes, Deborah E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. [Yaffe, Kristine; Friedl, Karl E.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA. [Yaffe, Kristine] San Francisco VA Med Ctr, San Francisco, CA USA. [Hoang, Tina D.] Northern Calif Inst Res & Educ, San Francisco, CA USA. RP Yaffe, K (reprint author), Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. EM kristine.yaffe@ucsf.edu FU United States Army Medical Research and Materiel Command FX Publication of this article was supported by the United States Army Medical Research and Materiel Command. NR 160 TC 6 Z9 6 U1 2 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 EI 1552-5279 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUN PY 2014 VL 10 IS 3 SU 1 BP S111 EP S121 DI 10.1016/j.jalz.2014.04.010 PG 11 WC Clinical Neurology SC Neurosciences & Neurology GA CP8GM UT WOS:000360130700007 PM 24924664 ER PT J AU U, KP Subramanian, V Nicholas, AP Thompson, PR Ferretti, P AF U, Kin Pong Subramanian, Venkataraman Nicholas, Antony P. Thompson, Paul R. Ferretti, Patrizia TI Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH LA English DT Article DE Apoptosis inducing factor (ALF); Cell death; Citrullination-deimination; Human neural stem cell; Peptidylarginine deiminase (PAD,PADI); Vimentin ID CHICK SPINAL-CORD; CITRULLINATED PROTEINS; MULTIPLE-SCLEROSIS; TRANSCRIPTIONAL REGULATION; RHEUMATOID-ARTHRITIS; NUCLEAR-LOCALIZATION; HUMAN KERATINOCYTES; CALPAIN-I; APOPTOSIS; MOUSE AB PADs (peptidylarginine deiminases) are calcium-dependent enzymes that change protein-bound arginine to citrulline (citrullination/deimination) affecting protein conformation and function. PAD up-regulation following chick spinal cord injury has been linked to extensive tissue damage and loss of regenerative capability. Having found that human neural stem cells (hNSCs) expressed PAD2 and PAD3, we studied PAD function in these cells and investigated PAD3 as a potential target for neuroprotection by mimicking calcium-induced secondary injury responses. We show that PAD3, rather than PAD2 is a modulator of cell growth/death and that PAD activity is not associated with caspase-3-dependent cell death, but is required for AIF (apoptosis inducing factor)-mediated apoptosis. PAD inhibition prevents association of PAD3 with AIF and AIF cleavage required for its translocation to the nucleus. Finally, PAD inhibition also hinders calcium-induced cytoskeleton disassembly and association of PAD3 with vimentin, that we show to be associated also with AIF; together this suggests that PAD-dependent cytoskeleton disassembly may play a role in AIF translocation to the nucleus. This is the first study highlighting a role of PAD activity in balancing hNSC survival/death, identifying PAD3 as an important upstream regulator of calciuminduced apoptosis, which could be targeted to reduce neural loss, and shedding light on the mechanisms involved. (C) 2014 The Authors. Published by Elsevier B.V. C1 [U, Kin Pong; Ferretti, Patrizia] UCL Inst Child Hlth, Dev Biol Unit, 30 Guilford St, London WC1N LEH, England. [Subramanian, Venkataraman; Thompson, Paul R.] Scripps Res Inst, Dept Chem, Scripps Florida, FL 33458 USA. [Nicholas, Antony P.] Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35294 USA. [Nicholas, Antony P.] Birmingham VA Med Ctr, Birmingham, AL 35294 USA. RP Ferretti, P (reprint author), UCL Inst Child Hlth, Dev Biol Unit, 30 Guilford St, London WC1N LEH, England. EM p.ferretti@ucl.ac.uk OI Ferretti, Patrizia/0000-0002-3590-6772 FU Child Research Appeal Trust [08DB04]; Biotechnology and Biological Sciences Research Council; National Institutes of Health [GM079357]; Medical Research Council [G070089]; Wellcome Trust [GR082557] FX This work was supported by grants from the Child Research Appeal Trust (grant 08DB04 to PF), the Biotechnology and Biological Sciences Research Council (PF) and the National Institutes of Health (grant GM079357 to PRT). The human embryonic and fetal material was provided by the Human Developmental Biology Resource (http://lidbr.org) jointly funded by the Medical Research Council (grant G070089) and The Wellcome Trust (grant GR082557). We are grateful to J. Ham, JP Brockes and JC Sowden for reading the manuscript. The authors declare no competing financial interests. NR 68 TC 10 Z9 10 U1 3 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-4889 EI 0006-3002 J9 BBA-MOL CELL RES JI Biochim. Biophys. Acta-Mol. Cell Res. PD JUN PY 2014 VL 1843 IS 6 BP 1162 EP 1171 DI 10.1016/j.bbamcr.2014.02.018 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA AG7VW UT WOS:000335627900011 PM 24607566 ER PT J AU Johnson, SD De Costa, AMA Young, MRI AF Johnson, Sara D. De Costa, Anna-Maria A. Young, M. Rita I. TI Effect of the Premalignant and Tumor Microenvironment on Immune Cell Cytokine Production in Head and Neck Cancer SO CANCERS LA English DT Article DE head and neck cancer; immunosuppression; tumor microenvironment; cytokines AB Head and neck squamous cell carcinoma (HNSCC) is marked by immunosuppression, a state in which the established tumor escapes immune attack. However, the impact of the premalignant and tumor microenvironments on immune reactivity has yet to be elucidated. The purpose of this study was to determine how soluble mediators from cells established from carcinogen-induced oral premalignant lesions and HNSCC modulate immune cell cytokine production. It was found that premalignant cells secrete significantly increased levels of G-CSF, RANTES, MCP-1, and PGE(2) compared to HNSCC cells. Splenocytes incubated with premalignant supernatant secreted significantly increased levels of Th1-,Th2-, and Th17-associated cytokines compared to splenocytes incubated with HNSCC supernatant. These studies demonstrate that whereas the premalignant microenvironment elicits proinflammatory cytokine production, the tumor microenvironment is significantly less immune stimulatory and may contribute to immunosuppression in established HNSCC. C1 [Johnson, Sara D.] Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA. [De Costa, Anna-Maria A.; Young, M. Rita I.] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave, Charleston, SC 29425 USA. [Young, M. Rita I.] Med Univ South Carolina, Dept Med, Charleston, SC 29425 USA. [Young, M. Rita I.] Ralph H Johnson Vet Affairs Med Ctr, Med Res Serv 151, Charleston, SC 29401 USA. RP Young, MRI (reprint author), Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave, Charleston, SC 29425 USA. EM johsad@musc.edu; clarkann@musc.edu; rita.young@va.gov FU Research Service of the Department of Veterans Affairs; National Institutes of Health [RO1 CA128837, RO1 DE018268] FX This work was supported by Research Service of the Department of Veterans Affairs and by grants RO1 CA128837 and RO1 DE018268 from the National Institutes of Health (MRIY). NR 44 TC 11 Z9 11 U1 0 U2 0 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2072-6694 J9 CANCERS JI Cancers PD JUN PY 2014 VL 6 IS 2 BP 756 EP 770 DI 10.3390/cancers6020756 PG 15 WC Oncology SC Oncology GA V47KL UT WOS:000209950600008 PM 24698959 ER PT J AU Lin, Y Sharma, S John, MS AF Lin, Yuan Sharma, Sherven John, Maie St. TI CCL21 Cancer Immunotherapy SO CANCERS LA English DT Review DE CCL21; cancer immunotherapy; dendritic cell; polymer; T cell AB Cancer, a major health problem, affects 12 million people worldwide every year. With surgery and chemo-radiation the long term survival rate for the majority of cancer patients is dismal. Thus novel treatments are urgently needed. Immunotherapy, the harnessing of the immune system to destroy cancer cells is an attractive option with potential for long term anti-tumor benefit. Cytokines are biological response modifiers that stimulate anti-tumor immune responses. In this review, we discuss the anti-tumor efficacy of the chemotactic cytokine CCL21 and its pre-clinical and clinical application in cancer. C1 [Lin, Yuan; John, Maie St.] UCLA, David Geffen Sch Med, Dept Head & Neck Surg, 10833 Conte Ave, Los Angeles, CA 90095 USA. [Lin, Yuan; Sharma, Sherven; John, Maie St.] UCLA, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, 10833 Conte Ave, Los Angeles, CA 90095 USA. [Lin, Yuan; John, Maie St.] UCLA, David Geffen Sch Med, UCLA Head & Neck Canc Program, 10833 Conte Ave, Los Angeles, CA 90095 USA. [Lin, Yuan; Sharma, Sherven; John, Maie St.] UCLA, David Geffen Sch Med, Clin & Translat Sci Inst, 10833 Conte Ave, Los Angeles, CA 90095 USA. [Lin, Yuan; Sharma, Sherven] UCLA, David Geffen Sch Med, Dept Med, Div Pulm & Crit Care Med, 37-131 CHS,10833 Conte Ave, Los Angeles, CA 90095 USA. [Sharma, Sherven] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. RP Lin, Y (reprint author), UCLA, David Geffen Sch Med, Dept Head & Neck Surg, 10833 Conte Ave, Los Angeles, CA 90095 USA.; Lin, Y (reprint author), UCLA, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, 10833 Conte Ave, Los Angeles, CA 90095 USA.; Lin, Y (reprint author), UCLA, David Geffen Sch Med, UCLA Head & Neck Canc Program, 10833 Conte Ave, Los Angeles, CA 90095 USA.; Lin, Y (reprint author), UCLA, David Geffen Sch Med, Clin & Translat Sci Inst, 10833 Conte Ave, Los Angeles, CA 90095 USA.; Lin, Y (reprint author), UCLA, David Geffen Sch Med, Dept Med, Div Pulm & Crit Care Med, 37-131 CHS,10833 Conte Ave, Los Angeles, CA 90095 USA. EM yuanlin@mednet.ucla.edu RI lin, yuan/E-6062-2011 FU American Academy of Otolaryngology-American Head & Neck Society Surgeon Scientist Career Development Award; Tobacco-Related Disease Research Program of the University of California; STOP Cancer Foundation; Jonsson Cancer Center; NIDCR K23; Department of Veterans Affairs Medical Research Funds; National Institutes of Health (NIH) Grants [RO1 CA126944]; Tobacco Related Disease Program Award Program of University of California [15RT-0207, 20FT0082] FX This project was supported by the American Academy of Otolaryngology-American Head & Neck Society Surgeon Scientist Career Development Award (MSJ), the Tobacco-Related Disease Research Program of the University of California (MSJ), the STOP Cancer Foundation (MSJ), The Jonsson Cancer Center, and NIDCR K23 (MSJ) and Department of Veterans Affairs Medical Research Funds (SS), National Institutes of Health (NIH) Grants (RO1 CA126944) and Tobacco Related Disease Program Award Program of University of California (15RT-0207 and 20FT0082). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 7 Z9 7 U1 0 U2 1 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2072-6694 J9 CANCERS JI Cancers PD JUN PY 2014 VL 6 IS 2 BP 1098 EP 1110 DI 10.3390/cancers6021098 PG 13 WC Oncology SC Oncology GA V47KL UT WOS:000209950600024 PM 24810425 ER PT J AU Bauman, WA Swonger, KN Rivera, DR LaFountaine, MF AF Bauman, William A. Swonger, Kirsten N. Rivera, Dwindally Rosado LaFountaine, Michael F. TI HOMA beta-Cell Function Negatively Correlates to the Vasodilatory Response of Insulin in the Cutaneous Microvasculature SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Bauman, William A.; Swonger, Kirsten N.; Rivera, Dwindally Rosado] James J Peters VA Med Ctr, Bronx, NY USA. [LaFountaine, Michael F.] Seton Hall Univ, S Orange, NJ 07079 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SAT-1029 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805107120 ER PT J AU Cunningham, GR Rosen, RC Wang, C Stephens, A Ellenberg, S Matsumoto, AM Bhasin, S Molitch, ME Farrar, JT Cella, D Gill, TM Barrett-Connor, EL Cauley, JA Cifelli, D Crandall, JP Ensrud, KE Fluharty, L Hadley, E Lewis, CE Pahor, M Resnick, SM Romashkan, S Swerdloff, RS Snyder, PJ AF Cunningham, Glenn R. Rosen, Raymond C. Wang, Christina Stephens, Alisa Ellenberg, Susan Matsumoto, Alvin M. Bhasin, Shalender Molitch, Mark E. Farrar, John T. Cella, David Gill, Thomas M. Barrett-Connor, Elizabeth Louise Cauley, Jane A. Cifelli, Denise Crandall, Jill P. Ensrud, Kristine E. Fluharty, Laura Hadley, Evan Lewis, Cora E. Pahor, Marco Resnick, Susan M. Romashkan, Sergei Swerdloff, Ronald S. Snyder, Peter J. TI Free Testosterone but Not Total Testosterone or Estradiol Is Associated with Sexual Function in Symptomatic Older Hypogonadal Men in the Sexual Function Trial of the Testosterone Trials SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Cunningham, Glenn R.] Baylor Coll Med, Houston, TX 77030 USA. [Rosen, Raymond C.] New England Res Inst Inc, Watertown, MA USA. [Wang, Christina] Harbor UCLA Med Ctr, Torrance, CA 90509 USA. [Wang, Christina; Swerdloff, Ronald S.] Los Angeles Biomed Res Inst, Torrance, CA USA. [Stephens, Alisa; Ellenberg, Susan; Farrar, John T.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Matsumoto, Alvin M.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Bhasin, Shalender] Brigham & Womens Hosp, Boston, MA 02115 USA. [Molitch, Mark E.; Cella, David] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Gill, Thomas M.] Yale Sch Med, New Haven, CT USA. [Barrett-Connor, Elizabeth Louise] Univ CA San Diego, La Jolla, CA USA. [Cauley, Jane A.] Univ Pittsburgh, Pittsburgh, PA USA. [Cifelli, Denise; Fluharty, Laura] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Crandall, Jill P.] Albert Einstein Coll Med, Bronx, NY 10467 USA. [Ensrud, Kristine E.] Univ Minnesota, Minneapolis, MN USA. [Hadley, Evan; Romashkan, Sergei] NIA, Bethesda, MD 20892 USA. [Lewis, Cora E.] Univ Alabama Birmingham, Birmingham, AL USA. [Pahor, Marco] Univ Florida, Gainesville, FL USA. [Resnick, Susan M.] NIA, Baltimore, MD 21224 USA. [Swerdloff, Ronald S.] Harbor Univ Calif Med Ctr, Torrance, CA USA. [Snyder, Peter J.] Univ PA, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SUN-0084 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805107199 ER PT J AU Grimes, MC Mathew, I Bandi, A Martin, E Codario, R Rao, RH AF Grimes, Michael C. Mathew, Indu Bandi, Archana Martin, Emily Codario, Ronald Rao, R. Harsha TI Impact of U-500 Insulin on Glycemic Control, Risk of Hypoglycemia, and Mortality in Patients with Extreme Insulin Resistance: The VA Pittsburgh Experience SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Grimes, Michael C.; Mathew, Indu] VA Pittsburgh Hlth Syst, Pittsburgh, PA USA. [Bandi, Archana] VAPHS Oakland, Wexford, PA USA. [Martin, Emily] VA Pittsburgh Healthcare Syst, Munhall, PA USA. [Codario, Ronald] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Rao, R. Harsha] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA OR54-6 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805100135 ER PT J AU Hershman, JM Liwanpo, L Ro, C ul Haq, MS AF Hershman, Jerome M. Liwanpo, Llanyee Ro, Cynthia ul Haq, Muhammd Salman TI Sunitinib Does Not Inhibit Thyroid Peroxidase in Patients SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Hershman, Jerome M.] VA Greater LA Healthcare Syst, Los Angeles, CA USA. [Liwanpo, Llanyee; Ro, Cynthia] VA Greater Los Angeles, Los Angeles, CA USA. [ul Haq, Muhammd Salman] Sansum Clin, Santa Barbara, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA MON-0507 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805109004 ER PT J AU Jensen, T Wang, CCL AF Jensen, Thomas Wang, Cecilia C. Low TI Double Trouble: A Case of Primary Hyperparathyroidism and Humoral Hypercalcemia of Malignancy SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Jensen, Thomas] Univ Colorado, Sch Med, Aurora, CO USA. [Wang, Cecilia C. Low] Denver VAMC, Denver, CO USA. [Wang, Cecilia C. Low] Univ Colorado Sh, Denver, CO USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SAT-0202 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805105128 ER PT J AU Kocarnik, BM Kahn, SE Fujimoto, WY Hayashi, T McNeely, MJ Leonetti, D Boyko, EJ AF Kocarnik, Beverly M. Kahn, Steven E. Fujimoto, Wilfred Y. Hayashi, Tomoshige McNeely, Marguerite J. Leonetti, Donna Boyko, Edward J. TI Estradiol Levels in Men Are Not Correlated Cross-Sectionally with Intra-Abdominal Fat Area and Do Not Predict Change in This Fat Depot Longitudinally SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Kocarnik, Beverly M.; Kahn, Steven E.; McNeely, Marguerite J.; Leonetti, Donna] Univ Washington, Seattle, WA 98195 USA. [Kahn, Steven E.; Boyko, Edward J.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Fujimoto, Wilfred Y.] Univ Washington, Kailua Kona, HI USA. [Hayashi, Tomoshige] Osaka Univ, Osaka, Japan. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SAT-0905 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805103097 ER PT J AU Liu, XH Collier, L Ma, RS Latif, R Davies, TF Bauman, WA Cardozo, CP AF Liu, Xin-Hua Collier, Lauren Ma, Risheng Latif, Rauf Davies, Terry F. Bauman, William A. Cardozo, Christopher Pratt TI Androgens Promote Differentiation of Induced Pluripotent Stem Cells to Mesenchymal Progenitor Cells through Embryoid Body Formation SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Liu, Xin-Hua; Collier, Lauren; Bauman, William A.; Cardozo, Christopher Pratt] JJ Peter VA Med Ctr, Bronx, NY USA. [Ma, Risheng] Mt Sinai Sch Med, Bronx, NY USA. [Latif, Rauf; Davies, Terry F.] Mt Sinai Sch Med, New York, NY USA. [Bauman, William A.] James J Peters VA Med Ctr, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA MON-0262 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805105285 ER PT J AU Lombardi, A Inabnet, WB Owen, R Tomer, Y AF Lombardi, Angela Inabnet, William B. Owen, Randall Tomer, Yaron TI A New Mechanism for Iodine Independent Amiodarone-Induced Thyroiditis with Translational Implications SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Lombardi, Angela; Inabnet, William B.; Owen, Randall; Tomer, Yaron] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Tomer, Yaron] James J Peters VA Med Ctr, New York, NY USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA OR12-3 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805109054 ER PT J AU Malhotra, S Gupta, N Galiveeti, S Milekic, B Greenberg, PD AF Malhotra, Sheetal Gupta, Namita Galiveeti, Sneha Milekic, Bojana Greenberg, Pietra Dale TI Sleeve Gastrectomy Outcomes in Veterans with Type II Diabetes SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Malhotra, Sheetal; Galiveeti, Sneha; Milekic, Bojana] JJ Peters VA Med Ctr, Bronx, NY USA. [Gupta, Namita] Univ Nebraska Med Ctr, Omaha, NE USA. [Greenberg, Pietra Dale] James J Peters VA Med Ctr, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA OR40-4 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805100127 ER PT J AU Mathew, I Grimes, MC Rao, RH Cunningham, CA Muder, R Perreiah, PL AF Mathew, Indu Grimes, Michael C. Rao, R. Harsha Cunningham, Candace Ann Muder, Robert Perreiah, Peter L. TI Eliminating Deaths from Mediastinitis after Cardiac Surgery Using Aggressive Glycemic Intervention to Maintain Blood Glucose 80-140mg/DI: The VA Pittsburgh Experience SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Mathew, Indu; Grimes, Michael C.; Muder, Robert] VA Pittsburgh Hlth Syst, Pittsburgh, PA USA. [Rao, R. Harsha; Cunningham, Candace Ann; Perreiah, Peter L.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA MON-0956 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805106240 ER PT J AU Muram, D Matsumoto, AM Zhang, X Cui, ZLL AF Muram, David Matsumoto, Alvin M. Zhang, Xiang Cui, Zhanglin Lin TI Application of the Endocrine Society Clinical Guidelines on Testosterone Therapy in Men with Androgen Deficiency Syndromes in Clinical Practice SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Muram, David; Zhang, Xiang; Cui, Zhanglin Lin] Eli Lilly & Co, Indianapolis, IN 46285 USA. [Matsumoto, Alvin M.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA MON-0021 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805104173 ER PT J AU Qin, WP Pan, JP Bauman, WA Cardozo, CP AF Qin, Weiping Pan, Jianping Bauman, William A. Cardozo, Christopher Pratt TI Molecular Crosstalk Between Calcineurin and mTORC1 Signaling Pathways SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Qin, Weiping; Pan, Jianping; Bauman, William A.; Cardozo, Christopher Pratt] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA MON-0351 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805100258 ER PT J AU Shi, Y Kim, MS Shu, ZJ Salmon, A Kamat, A AF Shi, Yun Kim, Margaret S. Shu, Zhen-Ju Salmon, Adam Kamat, Amrita TI Positive Association Between Beta(2)-Adrenergic Receptor (beta(2)-AR) Signaling and Cide Family Proteins in Hepatic Steatosis SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Shi, Yun; Kim, Margaret S.; Shu, Zhen-Ju] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Salmon, Adam; Kamat, Amrita] South Texas Vet Hlth Care Syst, San Antonio, TX USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA OR15-2 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805106048 ER PT J AU Shores, MM Fox, AE Moore, KP Matsumoto, AM Forsberg, CW Smith, NL Heckbert, SR Thompson, ML Walsh, TJ AF Shores, Molly M. Fox, Alexandra E. Moore, Kathryn P. Matsumoto, Alvin M. Forsberg, Christopher W. Smith, Nicholas L. Heckbert, Susan R. Thompson, Mary Lou Walsh, Thomas J. TI Characteristics of Treated and Untreated Middle-Aged and Older Men with Low Testosterone and Testosterone Use in a National Veterans Affairs (VA) Cohort SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Shores, Molly M.] Univ Washington, VA Puget Sound, Seattle, WA 98195 USA. [Fox, Alexandra E.] Seattle VA Epidemiol Res & Informat Ctr ERIC, Seattle, WA USA. [Moore, Kathryn P.; Forsberg, Christopher W.] Seattle VA ERIC, Seattle, WA USA. [Matsumoto, Alvin M.] VA Puget Sound Hlth Care Syste, Seattle, WA USA. [Smith, Nicholas L.; Heckbert, Susan R.; Thompson, Mary Lou; Walsh, Thomas J.] Univ Washington, Seattle, WA 98195 USA. [Smith, Nicholas L.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SUN-0077 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805107192 ER PT J AU Teng, XC Jin, T Brent, GA Wu, AH Teng, WP Shan, ZY AF Teng, Xiaochun Jin, Ting Brent, Gregory A. Wu, An-hua Teng, Weiping Shan, Zhongyan TI A Girl with Resistance to Thyroid Hormone (P453T) and a Suspected Thyrotropin-Secreting Pituitary Microadenoma SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Teng, Xiaochun; Jin, Ting; Shan, Zhongyan] Inst Endocrinol, Shenyang, Peoples R China. [Brent, Gregory A.] Univ Calif Los Angeles, David Geffen Sch Med, Vet Affairs Greater Los Angeles Healthcare Syst, Mol Endocrinol Lab,Dept Med, Tarzana, CA USA. [Brent, Gregory A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Tarzana, CA USA. [Wu, An-hua] Dept Neurosurg, Shenyang, Peoples R China. [Teng, Weiping] Endocrine Inst, Shenyang, Peoples R China. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA MON-0488 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805108315 ER PT J AU Walker, RJ Smalls, BL Hernandez-Tejada, MA Campbell, JA Egede, LE AF Walker, Rebekah J. Smalls, Brittany L. Hernandez-Tejada, Melba A. Campbell, Jennifer A. Egede, Leonard E. TI EFFECT OF DIABETES SELF-EFFICACY ON GLYCEMIC CONTROL, MEDICATION ADHERENCE, SELF-CARE BEHAVIORS, AND QUALITY OF LIFE IN A PREDOMINANTLY LOW-INCOME, MINORITY POPULATION SO ETHNICITY & DISEASE LA English DT Article DE Diabetes Self-efficacy; Glycemic Control; Medication Adherence; Self-care Behaviors; Quality of Life; Low-income Population; Type 2 Diabetes ID AFRICAN-AMERICAN; FOOD INSECURITY; SOCIOECONOMIC-STATUS; HEALTH LITERACY; MANAGEMENT; ADULTS; INTERVENTION; ASSOCIATION; PERCEPTIONS; STRATEGIES AB Objective: This study examined the effect of self-efficacy on glycemic control, self-care behaviors, and quality of life in low-income, minority adults with diabetes. Methods: Data on 378 participants were examined. Multiple linear regression assessed associations between self-efficacy, hemoglobin A1c, medication adherence, diabetes knowledge, self-care behaviors and quality of life. Results: Self-efficacy had modest correlations with glycemic control (r = -2.250, P < .001), medication adherence (r = -.352, P < .001), diabetes knowledge (r = -.118, P < .039), diet (r = -.420, P < .001), exercise (r = -.220, P < .001), blood sugar testing (r = -.213, P < .001), foot care (r = .121, P < .032), and mental health related quality of life (r = .137, P < .017). In the regression model, self-efficacy was significantly associated with glycemic control (beta = -.104, 95% CI: - .157, - .051), medication adherence (beta = -.067, 95% CI: - .090, - .044), diet (beta = .150, 95% CI:.108,.191), exercise (beta = -.113, 95% CI:.065,.161), blood sugar testing (beta = .107, 95% CI:.049,.164) and mental health related quality of life (beta = .112, 95% CI:.051,.173). Conclusion: Higher self-efficacy was associated with improved glycemic control, medication adherence, self-care behavior and mental health related quality of life. Practice Implications: Emphasis on self-efficacy is relevant for educational interventions developed for low-income, minority populations. C1 [Walker, Rebekah J.; Smalls, Brittany L.; Hernandez-Tejada, Melba A.; Campbell, Jennifer A.; Egede, Leonard E.] Med Univ S Carolina, Ctr Hlth Dispar Res, Charleston, SC 29425 USA. [Egede, Leonard E.] Med Univ S Carolina, Div Gen Internal Med & Geriatr, Dept Med, Charleston, SC 29425 USA. [Egede, Leonard E.] Ralph H Johnson VA Med Ctr, Hlth Equity & Rural Outreach Innovat Ctr, Charleston VA COIN, Charleston, SC USA. RP Egede, LE (reprint author), Med Univ S Carolina, Ctr Hlth Dispar Res, 135 Rutledge Ave,Room 280G,POB 250593, Charleston, SC 29425 USA. EM egedel@musc.edu FU National Institute for Diabetes, Digestive and Kidney Disease [T35DK007431] FX Supported by Grant #T35DK007431 from the National Institute for Diabetes, Digestive and Kidney Disease. NR 53 TC 9 Z9 10 U1 1 U2 9 PU INT SOC HYPERTENSION BLACKS-ISHIB PI ATLANTA PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA SN 1049-510X EI 1945-0826 J9 ETHNIC DIS JI Ethn. Dis. PD SUM PY 2014 VL 24 IS 3 BP 349 EP 355 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CU7KT UT WOS:000363717300013 PM 25065078 ER PT J AU Boehme, AK McGwin, G Andes, DR Lyon, GM Chiller, T Pappas, PG Baddley, JW AF Boehme, Amelia K. McGwin, Gerald Andes, David R. Lyon, G. Marshall Chiller, Tom Pappas, Peter G. Baddley, John W. TI RACE AND INVASIVE FUNGAL INFECTION IN SOLID ORGAN TRANSPLANT RECIPIENTS SO ETHNICITY & DISEASE LA English DT Article DE Invasive Fungal Infection; Solid Organ Transplant; Aspergillosis; Candidiasis; Cryptococcosis ID SURVEILLANCE NETWORK TRANSNET; LIVER-TRANSPLANTATION; ETHNIC DISPARITIES; RISK-FACTORS; COCCIDIOIDOMYCOSIS; SURVIVAL; ACCESS AB Health disparities in access to solid organ transplantation (SOT) and graft survival are well recognized, but there are limited data on the relationship of race to risk of invasive fungal infection (IFI) among SOT recipients. We conducted a case-control study using data from the Transplant-Associated Infection Surveillance Network (TRANSNET) to investigate race and IFI. Cases (n=1,214) and controls (n=16,550) were compared on demographic variables using chi-square, and the relationship between race and IFI was assesses with unconditional logistic regression. Compared to White transplant patients, Blacks had similar odds of developing IFI (OR=.97, 95% CI 0.82-1.15, P=.7125), while participants who identified as other ethnicity were less likely to develop IFI (OR=.56, 95% CI .41-.75, P<.001). Blacks, when compared to White patients, were at increased odds of developing cryptococcal infection (OR 2.19, 95%CI 1.35-3.54, P=.002). Despite pharmacogenetic differences, Black transplant recipients were not more likely overall to develop IFI compared to White transplant recipients. C1 [Boehme, Amelia K.] Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA. [Andes, David R.] Univ Wisconsin, Madison, WI 53706 USA. [Lyon, G. Marshall] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Chiller, Tom] Ctr Dis Control, Atlanta, GA 30333 USA. [Pappas, Peter G.; Baddley, John W.] Univ Alabama Birmingham, Sch Med, Birmingham, AL 35294 USA. [Baddley, John W.] Birmingham VA Med Ctr, Birmingham, AL 35233 USA. RP Baddley, JW (reprint author), Univ Alabama Birmingham, Div Infect Dis, 1900 Univ Blvd,THT 229, Birmingham, AL 35294 USA. EM jbaddley@uab.edu FU CDC; Astellas; Pfizer; Merck; Schering Plough FX TRANSNET was sponsored by the CDC, Astellas, Pfizer, Merck, and Schering Plough. We would like to thank the following TRANSNET Investigators: Barbara Alexander, MD, Duke University; Elias Anaissie, MD, University of Arkansas; Michael Boeckh, MD, Fred Hutchinson Cancer Research Center; Janice Brown, MD, Stanford University; Lisa Brumble, MD, Mayo Clinic-Jacksonville; Alison Freifeld, MD, University of Nebraska; Yoav Golan, MD, and Susan Hadley, MD, Tufts University; Loreen Herwaldt, MD, University of Iowa; James Ito, MD, City of Hope National Medical Center; Carol Kauffman, MD, University of Michigan; Katherine Knapp, MD, St. Jude Children's Hospital; Dimitrios Kontoyiannis, MD, MD Anderson Cancer Center; Kieren Marr, MD and Trish Perl, MD, Johns Hopkins Medical Institute; Vicki Morrison, MD, University of Minnesota; Genovefa Papanicolaou, MD, Memorial Sloan-Kettering Cancer Center; Tom Patterson, MD, University of Texas HSC-San Antonio; Mindy Schuster, MD, University of Pennsylvania; Randall Walker, MD, Mayo Clinic-Rochester; Tom Walsh, MD, Weill Cornell Medical College; John Wingard, MD, University of Florida. NR 17 TC 1 Z9 1 U1 0 U2 0 PU INT SOC HYPERTENSION BLACKS-ISHIB PI ATLANTA PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA SN 1049-510X EI 1945-0826 J9 ETHNIC DIS JI Ethn. Dis. PD SUM PY 2014 VL 24 IS 3 BP 382 EP 385 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CU7KT UT WOS:000363717300018 PM 25065083 ER PT J AU Molina, Y Lehavot, K Beadnell, B Simoni, J AF Molina, Yamile Lehavot, Keren Beadnell, Blair Simoni, Jane TI Racial Disparities in Health Behaviors and Conditions Among Lesbian and Bisexual Women: The Role of Internalized Stigma SO LGBT HEALTH LA English DT Article DE bisexual; health disparities; lesbian/gay; physical health; race/ethnicity; women ID FEMINIST IDENTITY DEVELOPMENT; ACTIVITY QUESTIONNAIRE IPAQ; BODY-FAT DISTRIBUTION; SEXUAL ORIENTATION; AFRICAN-AMERICAN; PHYSICAL-ACTIVITY; US ADULTS; GAY MEN; PSYCHOLOGICAL DISTRESS; VEGETABLE INTAKE AB There are documented disparities in physical health behaviors and conditions, such as physical activity and obesity, with regard to both race/ethnicity and sexual orientation. However, physical health disparities for lesbian and bisexual (LB) women who are also racial minorities are relatively unexplored. Minority stressors, such as internalized stigma, may account for disparities in such multiply marginalized populations. We sought to (1) characterize inequalities among non-Hispanic white and African American LB women and (2) examine the roles of internalized sexism and homophobia in disparities. Data on health behaviors (diet, physical activity); physical health (hypertension, diabetes, overweight/obesity); internalized sexism; and internalized homophobia were collected via a web-based survey. Recruitment ads were sent electronically to over 200 listservs, online groups, and organizations serving the lesbian, gay, and bisexual community in all 50 U.S. states. The analytic sample consisted of 954 white and 75 African American LB women. African American participants were more likely than white participants to report low fruit/vegetable intake and physical activity, a higher body mass index, and a history of diabetes and hypertension. There were no racial differences in internalized homophobia, but African American women reported higher levels of internalized sexism. Internalized sexism partially mediated racial disparities in physical activity and diabetes, but not in the other outcomes. Findings suggest that African American LB women may be at greater risk than their white counterparts for poor health and that internalized sexism may be a mediator of racial differences for certain behaviors and conditions. C1 [Molina, Yamile] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA. [Molina, Yamile] Univ Illinois, Epidemiol & Biostat Div, Chicago, IL USA. [Molina, Yamile] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Lehavot, Keren] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Beadnell, Blair] Univ Washington, Sch Social Work, Seattle, WA 98195 USA. [Simoni, Jane] Univ Washington, Dept Psychol, Seattle, WA 98195 USA. [Lehavot, Keren] VA Puget Sound Hlth Care Syst, Seattle, WA USA. RP Molina, Y (reprint author), Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N,M3-B232, Seattle, WA 98109 USA. EM ymolina@fhcrc.org OI Simoni, Jane/0000-0002-8711-1576 FU Centers for Disease Control Grant for Public Health Research Dissertation [R36 CD000996]; National Cancer Institute Supplement to Promote Diversity in Health-Related Research [P50CA148143]; Biobehavioral Cancer Prevention and Control Training Program at the University of Washington [R25CA92408] FX This research was supported by a Centers for Disease Control Grant for Public Health Research Dissertation (R36 CD000996) award to K.L. Manuscript preparation was supported by funding to Y.M. through a National Cancer Institute Supplement to Promote Diversity in Health-Related Research (P50CA148143) and a postdoctoral fellowship through the Biobehavioral Cancer Prevention and Control Training Program at the University of Washington (R25CA92408). NR 89 TC 3 Z9 3 U1 3 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2325-8292 EI 2325-8306 J9 LGBT HEALTH JI LGBT Health PD JUN PY 2014 VL 1 IS 2 BP 131 EP 139 DI 10.1089/lgbt.2013.0007 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CR9PV UT WOS:000361689800012 PM 25364769 ER PT J AU Robbins, NM Swanson, RA AF Robbins, Nathaniel M. Swanson, Raymond A. TI Opposing Effects of Glucose on Stroke and Reperfusion Injury Acidosis, Oxidative Stress, and Energy Metabolism SO STROKE LA English DT Article DE acidosis; hemorrhage; hyperglycemia; hypoglycemia; reactive oxygen species; superoxides C1 [Robbins, Nathaniel M.; Swanson, Raymond A.] Univ Calif San Francisco, Dept Neurol, 4150 Clement St, San Francisco, CA 94121 USA. [Swanson, Raymond A.] San Francisco VA Med Ctr, Neurol Serv, San Francisco, CA USA. RP Swanson, RA (reprint author), Univ Calif San Francisco, Dept Neurol, 4150 Clement St, San Francisco, CA 94121 USA.; Swanson, RA (reprint author), Dept Vet Affairs Med Ctr, 4150 Clement St, San Francisco, CA 94121 USA. EM raymond.swanson@ucsf.edu OI Swanson, Raymond/0000-0002-3664-5359 FU National Institutes of Health [NS041421, NS081149]; Department of Veterans Affairs FX This review was supported by National Institutes of Health grants NS041421 and NS081149 to R.A. Swanson and by the Department of Veterans Affairs. NR 48 TC 11 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0039-2499 EI 1524-4628 J9 STROKE JI Stroke PD JUN PY 2014 VL 45 IS 6 BP 1881 EP 1886 DI 10.1161/STROKEAHA.114.004889 PG 6 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA V42VQ UT WOS:000209641700001 PM 24743441 ER PT J AU Chen, Y Won, SJ Xu, Y Swanson, RA AF Chen, Y. Won, S. J. Xu, Y. Swanson, R. A. TI Targeting Microglial Activation in Stroke Therapy: Pharmacological Tools and Gender Effects SO CURRENT MEDICINAL CHEMISTRY LA English DT Article DE Brain; corticosteroid; female; HDAC; inflammation; ischemia; minocycline; PARP ID FOCAL CEREBRAL-ISCHEMIA; HISTONE DEACETYLASE INHIBITORS; TUMOR-NECROSIS-FACTOR; GROUP BOX1-INHIBITING MECHANISM; BRAIN-INJURY; RAT-BRAIN; POLY(ADP-RIBOSE) POLYMERASE-1; GENE-EXPRESSION; FACTOR-ALPHA; CELL-DEATH AB Ischemic stroke is caused by critical reductions in blood flow to brain or spinal cord. Microglia are the resident immune cells of the central nervous system, and they respond to stroke by assuming an activated phenotype that releases cytotoxic cytokines, reactive oxygen species, proteases, and other factors. This acute, innate immune response may be teleologically adapted to limit infection, but in stroke this response can exacerbate injury by further damaging or killing nearby neurons and other cell types, and by recruiting infiltration of circulating cytotoxic immune cells. The microglial response requires hours to days to fully develop, and this time interval presents a clinically accessible time window for initiating therapy. Because of redundancy in cytotoxic microglial responses, the most effective therapeutic approach may be to target the global gene expression changes involved in microglial activation. Several classes of drugs can do this, including histone deacetylase inhibitors, minocycline and other PARP inhibitors, corticosteroids, and inhibitors of TNF alpha and scavenger receptor signaling. Here we review the pre-clinical studies in which these drugs have been used to suppress microglial activation after stroke. We also review recent advances in the understanding of sex differences in the CNS inflammatory response, as these differences are likely to influence the efficacy of drugs targeting post-stroke brain inflammation. C1 [Chen, Y.; Xu, Y.] Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China. [Chen, Y.; Won, S. J.; Swanson, R. A.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA. [Chen, Y.; Won, S. J.; Swanson, R. A.] San Francisco VA Med Ctr, Neurol Serv, San Francisco, CA 94121 USA. RP Swanson, RA (reprint author), Univ Calif San Francisco, Dept Neurol, 4150 Clement St, San Francisco, CA 94121 USA. EM raymond.swanson@ucsf.edu OI Swanson, Raymond/0000-0002-3664-5359 FU Chinese Research Scholarship Council; U.S. National Institutes of Health [NS041421]; U.S. Department of Veterans Affairs FX This work was supported by the Chinese Research Scholarship Council (Y.C.) the U.S. National Institutes of Health (grant # NS041421, R.A.S.), and the U.S. Department of Veterans Affairs. NR 132 TC 20 Z9 20 U1 0 U2 15 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 0929-8673 EI 1875-533X J9 CURR MED CHEM JI Curr. Med. Chem. PD JUN PY 2014 VL 21 IS 19 BP 2146 EP 2155 PG 10 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA AG4MF UT WOS:000335393300005 PM 24372213 ER PT J AU Fitten, LJ Ortiz, F Fairbanks, L Bartzokis, G Lu, P Klein, E Coppola, G Ringman, J AF Fitten, L. Jaime Ortiz, Freddy Fairbanks, Lynn Bartzokis, George Lu, Po Klein, Eric Coppola, Giovanni Ringman, John TI Younger age of dementia diagnosis in a Hispanic population in southern California SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Article DE diagnosis; Hispanic; onset; Alzheimer's disease; Latino; age; dementia; vascular dementia; APOE genotype; diagnosis ID APOLIPOPROTEIN-E EPSILON-4; MINI-MENTAL-STATE; OLDER MEXICAN-AMERICANS; ALZHEIMERS-DISEASE; DIABETES-MELLITUS; AFRICAN-AMERICANS; CARIBBEAN HISPANICS; NORTHERN MANHATTAN; RISK; ONSET AB Objective Prior studies of US Hispanics, largely performed on the East Coast, have found a younger age of dementia onset than in White non-Hispanics. We performed a cross-sectional study to examine clinical and sociodemographic variables associated with age of dementia diagnosis in older Hispanics and White, non-Hispanics in southern California. Methods Two hundred ninety (110 Hispanic and 180 White non-Hispanic) community dwelling, cognitively symptomatic subjects, aged 50 years and older, were assessed and diagnosed with probable Alzheimer's disease or probable vascular dementia. Apolipoprotein E (APOE) genotype was assessed in a subset of cases. Analysis of variance and multiple stepwise linear regression were used to assess main effects and interactions of ethnicity with dementia severity (indexed by mini mental state examination scores) and other sociodemographic and clinical variables on age of dementia diagnosis. Results Hispanics were younger by an average of 4 years at the time of diagnosis, regardless of dementia subtype, despite a similar prevalence of the APOE epsilon 4 genotype. The earlier age at diagnosis for Hispanics was not explained by gender, dementia severity, years of education, history of hypercholesterolemia, hypertension, or diabetes. Only ethnicity was significantly associated with age of onset. Conclusions These findings confirm that US Hispanics living in the southwestern USA tend to be younger at the time of dementia diagnosis than their White non-Hispanic counterparts. As this is not explained by the presence of the APOE epsilon 4 genotype, further studies should explore other cultural, medical, or genetic risk factors influencing the age of dementia onset in this population. Copyright (c) 2014 John Wiley & Sons, Ltd. C1 [Fitten, L. Jaime; Ortiz, Freddy; Fairbanks, Lynn; Bartzokis, George; Lu, Po; Coppola, Giovanni; Ringman, John] Univ Calif Los Angeles, David Geffen Sch Med, Easton Ctr Alzheimer Dis Res, Los Angeles, CA 90095 USA. [Fitten, L. Jaime; Ortiz, Freddy] US Dept Vet Affairs, Greater Los Angeles Vet Affairs Healthcare Syst, Sepulveda Ambulatory Care Ctr, Los Angeles, CA USA. [Fitten, L. Jaime; Ortiz, Freddy] Univ Calif Los Angeles, Med Ctr, Dept Psychiat Olive View, Los Angeles, CA 90024 USA. [Fitten, L. Jaime; Fairbanks, Lynn; Bartzokis, George; Lu, Po; Klein, Eric; Coppola, Giovanni] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Ortiz, Freddy; Lu, Po; Ringman, John] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA. [Bartzokis, George] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA. [Bartzokis, George] Greater Los Angeles VA Healthcare Syst, West Los Angeles, CA USA. RP Fitten, LJ (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Easton Ctr Alzheimer Dis Res, Los Angeles, CA 90095 USA. EM jfitten@ucla.edu FU NIA-UCLA ADRC [P50 AG16570]; State of California Alzheimer's Disease Center at UCLA, the Easton Consortium for Alzheimer's Disease Drug Discovery and Biomarker Development; Olive View-UCLA Medical Center, Sylmar, CA, USA; VA Greater Los Angeles Healthcare System, Sepulveda, CA, USA FX This study was supported by funding from the NIA-UCLA ADRC (P50 AG16570); by the State of California Alzheimer's Disease Center at UCLA, the Easton Consortium for Alzheimer's Disease Drug Discovery and Biomarker Development; by the Olive View-UCLA Medical Center, Sylmar, CA, USA; and by the VA Greater Los Angeles Healthcare System, Sepulveda, CA, USA. NR 37 TC 6 Z9 6 U1 3 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6230 EI 1099-1166 J9 INT J GERIATR PSYCH JI Int. J. Geriatr. Psychiatr. PD JUN PY 2014 VL 29 IS 6 BP 586 EP 593 DI 10.1002/gps.4040 PG 8 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA AG2ND UT WOS:000335252300005 PM 24478258 ER PT J AU Raskind, MA Wang, LY AF Raskind, Murray A. Wang, Lucy Y. TI Antipsychotic drugs for psychosis and agitation in dementia: efficacy, safety, and a possible noradrenergic mechanism of action SO INTERNATIONAL PSYCHOGERIATRICS LA English DT Editorial Material ID PLACEBO-CONTROLLED-TRIAL; NURSING-HOME RESIDENTS; ALZHEIMERS-DISEASE; DOUBLE-BLIND; LOCUS-COERULEUS; BEHAVIORAL DISTURBANCES; SENILE DEMENTIA; CLINICAL-TRIAL; TYROSINE-HYDROXYLASE; COMPENSATORY CHANGES AB The first patient described by Alzheimer in 1907 had both progressive cognitive deterioration and prominent comorbid signs and symptoms of psychosis and agitation (Alzheimer, 1907, 1987). In this editorial, we use "psychosis" to denote delusions and hallucinations and "agitation" to denote irritability, aggression, pressured motor activity, and active resistance to necessary care. Although advances have been made in the treatment of these non-cognitive symptoms, these psychosis and agitation symptoms continued to be burdensome and costly for dementia patients, caregivers, and society. Among the pharmacologic treatments available for psychosis and agitation, antipsychotic drugs are the drug class most consistently demonstrated effective for psychosis and agitation in dementia (Lyketsos et al., 2006; APA Work Group on Alzheimer's Disease and Other Dementias et al., 2007). These are widely prescribed for these behavioral problems, but their use remains controversial and their mechanism of action unclear. C1 [Raskind, Murray A.] Univ Washington, Vet Affairs Northwest Network VISN 20, Mental Illness Res Educ & Clin Ctr, Mental Hlth Serv,VA Puget Sound Hlth Care Syst, Seattle, WA 98195 USA. Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. RP Raskind, MA (reprint author), Univ Washington, Vet Affairs Northwest Network VISN 20, Mental Illness Res Educ & Clin Ctr, Mental Hlth Serv,VA Puget Sound Hlth Care Syst, Seattle, WA 98195 USA. EM murray.raskind@va.gov NR 45 TC 1 Z9 1 U1 1 U2 15 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1041-6102 EI 1741-203X J9 INT PSYCHOGERIATR JI Int. Psychogeriatr. PD JUN PY 2014 VL 26 IS 6 BP 879 EP 883 AR PII S1041610214000477 DI 10.1017/S1041610214000477 PG 5 WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry; Psychology SC Psychology; Geriatrics & Gerontology; Psychiatry GA AG4RK UT WOS:000335407700001 PM 24703502 ER PT J AU Vatsavayi, AVV Kofler, J DeMichele-Sweet, MAA Murray, PS Lopez, OL Sweet, RA AF Vatsavayi, Anil Varma V. Kofler, Julia DeMichele-Sweet, Mary Ann A. Murray, Patrick S. Lopez, Oscar L. Sweet, Robert A. TI TAR DNA-binding protein 43 pathology in Alzheimer's disease with psychosis SO INTERNATIONAL PSYCHOGERIATRICS LA English DT Article DE Alzheimer's disease; TDP-43; psychosis ID FRONTOTEMPORAL LOBAR DEGENERATION; NEUROPATHOLOGIC ASSESSMENT; TDP-43 IMMUNOREACTIVITY; HIPPOCAMPAL SCLEROSIS; RISK-FACTORS; DELUSIONS; SYMPTOMS; PHENOTYPE; DEMENTIA; BEHAVIOR AB Background: TAR DNA-binding protein 43 (TDP-43) has been identified as a major disease protein in frontotemporal lobar degeneration. More recently, TDP-43 proteinopathy has also been observed in Alzheimer's disease (AD) with a characteristic distribution of TDP-43 predominantly in the mesial temporal lobe, and to a lesser degree in the neocortical areas. AD subjects with psychotic symptoms (AD+P) represent a subgroup characterized by greater impairment of frontal cortex-dependent cognitive functions and more severe frontal cortical neuropathology. The aim of this study is to determine whether there is an association between TDP-43 pathology and AD+P. We hypothesized that TDP-43 pathology would be more frequent in AD+P than in AD without psychosis. Methods: We studied the presence and distribution of TDP-43 pathology by immunohistochemistry in the dentate gyrus (DG) and prefrontal cortex (FC) of postmortem brain specimens from 68 subjects with a primary neuropathologic diagnosis of AD as determined by the Neuropathology Core of the University of Pittsburgh Alzheimer's Disease Research Center. Results: Forty-five (66%) subjects were classified as AD+P. Fourteen (20.6%) subjects had TDP-43 pathology in DG, eight (11.8%) had TDP-43 pathology in FC, and six (8.8%) had TDP-43 pathology in both regions. TDP-43 in DG was not significantly associated with AD+P. However, TDP-43 in FC demonstrated a trend toward reduced likelihood of psychosis (p = 0.068). TDP-43 pathology in DG, but not FC, was significantly associated with greater age at death and longer duration of illness. Conclusions: Our findings indicate that there was no association between concomitant TDP-43 pathology in DG or FC and AD+P. C1 [Vatsavayi, Anil Varma V.; Murray, Patrick S.; Sweet, Robert A.] Univ Pittsburgh, Sch Med, Translat Neurosci Program, Pittsburgh, PA USA. [Vatsavayi, Anil Varma V.; DeMichele-Sweet, Mary Ann A.; Murray, Patrick S.; Lopez, Oscar L.; Sweet, Robert A.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA. [Vatsavayi, Anil Varma V.; Murray, Patrick S.; Sweet, Robert A.] VA Pittsburgh Healthcare Syst, VISN Mental Illness Res Educ & Clin Ctr 4, Pittsburgh, PA USA. [Lopez, Oscar L.; Sweet, Robert A.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA. [Kofler, Julia] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA. RP Sweet, RA (reprint author), Biomed Sci Tower,W1645 3811,OHara St, Pittsburgh, PA 15213 USA. EM sweetra@upmc.edu OI Murray, Patrick/0000-0002-6525-2888 FU National Institute of Aging [AG05133, AG027224]; VA Pittsburgh Healthcare System (VAPHS) [BX000452] FX This work was supported in part by the National Institute of Aging grants AG05133 (OLL) and AG027224 (RAS), and the VA Pittsburgh Healthcare System (VAPHS) grant BX000452 (RAS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health, the National Institutes of Health, the Department of Veterans Affairs, or the United States Government. NR 40 TC 3 Z9 3 U1 2 U2 11 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1041-6102 EI 1741-203X J9 INT PSYCHOGERIATR JI Int. Psychogeriatr. PD JUN PY 2014 VL 26 IS 6 BP 987 EP 994 DI 10.1017/S1041610214000246 PG 8 WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry; Psychology SC Psychology; Geriatrics & Gerontology; Psychiatry GA AG4RK UT WOS:000335407700013 PM 24588894 ER PT J AU Minzenberg, MJ Gomes, GC Yoon, JH Watrous, AJ Geng, J Firl, AJ Carter, CS AF Minzenberg, Michael J. Gomes, Glenn C. Yoon, Jong H. Watrous, Andrew J. Geng, Joy Firl, Alana J. Carter, Cameron S. TI Modafinil augments oscillatory power in middle frequencies during rule selection SO PSYCHOPHYSIOLOGY LA English DT Article DE Prefrontal cortex; Cognitive control; Oscillations; Theta; Modafinil; Rule selection ID INDEPENDENT COMPONENT ANALYSIS; INTERNEURON DIVERSITY SERIES; PREFRONTAL CORTEX; LOCUS-COERULEUS; WORKING-MEMORY; THETA-OSCILLATIONS; COGNITIVE CONTROL; 1ST-EPISODE SCHIZOPHRENIA; PHASE SYNCHRONIZATION; NETWORK OSCILLATIONS AB Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30 Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30 Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control. C1 [Minzenberg, Michael J.] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA 94143 USA. [Minzenberg, Michael J.] San Francisco VA Med Ctr, San Francisco, CA USA. [Gomes, Glenn C.; Carter, Cameron S.] Univ Calif Davis, Sch Med, Dept Psychiat, Sacramento, CA 95817 USA. [Yoon, Jong H.] Stanford Univ, Sch Med, Dept Psychiat, Palo Alto, CA 94304 USA. [Yoon, Jong H.] Palo Alto Vet Affairs Med Ctr, Palo Alto, CA USA. [Watrous, Andrew J.; Geng, Joy; Carter, Cameron S.] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA. [Firl, Alana J.] Univ Calif Berkeley, Program Vis Neurosci, Berkeley, CA 94720 USA. RP Minzenberg, MJ (reprint author), 116C San Francisco Vet Affairs Med Ctr, Outpatient Mental Hlth Serv, 4150 Clement St, San Francisco, CA 94121 USA. EM Michael.minzenberg@ucsf.edu FU Doris Duke Charitable Foundation; NARSAD (Brain and Behavior Foundation); National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [UL1 RR024146]; NIH Roadmap for Medical Research FX This work was supported by a Clinical Scientist Development Award from the Doris Duke Charitable Foundation and a Young Investigator award from NARSAD (Brain and Behavior Foundation) to MJM. This publication was also made possible by Grant Number UL1 RR024146 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. The authors would like to acknowledge the assistance of Janeth Nunez del Prado, Jenny Yen, and Dennis Thompson in the conduct and analysis of the study. NR 84 TC 4 Z9 4 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0048-5772 EI 1469-8986 J9 PSYCHOPHYSIOLOGY JI Psychophysiology PD JUN PY 2014 VL 51 IS 6 BP 510 EP 519 DI 10.1111/psyp.12201 PG 10 WC Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental SC Psychology; Neurosciences & Neurology; Physiology GA AG1SL UT WOS:000335196300002 PM 24611660 ER PT J AU Kim, JY Kawabori, M Yenari, MA AF Kim, J. Y. Kawabori, M. Yenari, M. A. TI Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets SO CURRENT MEDICINAL CHEMISTRY LA English DT Article DE Brain ischemia; inflammation; neuroprotection; stroke ID FOCAL CEREBRAL-ISCHEMIA; BLOOD-BRAIN-BARRIER; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; INTERCELLULAR-ADHESION MOLECULE-1; CENTRAL-NERVOUS-SYSTEM; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST; NF-KAPPA-B; TRANSIENT FOREBRAIN ISCHEMIA AB Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by ischemia due to occlusion of a cerebral artery. Inflammation is known to result as a result of ischemic injury, long thought to be involved in initiating the recovery and repair process. However, work over the past few decades indicates that aspects of this inflammatory response may in fact be detrimental to stroke outcome. Acutely, inflammation appears to have a detrimental effect, and anti-inflammatory treatments have been been studied as a potential therapeutic target. Chronically, reports suggest that post-ischemic inflammation is also essential for the tissue repairing and remodeling. The majority of the work in this area has centered around innate immune mechanisms, which will be the focus of this review. This review describes the different key players in neuroinflammation and their possible detrimental and protective effects in stroke. A better understanding of the roles of the different immune cells and their temporal profile of damage versus repair will help to clarify more effective modulation of inflammation post stroke. C1 [Yenari, M. A.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA. San Francisco VA Med Ctr, San Francisco, CA 94121 USA. RP Yenari, MA (reprint author), Univ Calif San Francisco, Dept Neurol, Calif 4150 Clement St, San Francisco, CA 94121 USA. EM Yenari@alum.mit.edu FU National Institutes of Health [NS40516]; Veteran's Merit Award; American Heart Association; Uehara Foundation; Veterans Affairs Medical Center, San Francisco, California FX This work was supported by grants from the National Institutes of Health (NS40516, to MY), the Veteran's Merit Award (MY), the American Heart Association (to JYK), and the Uehara Foundation (2013 Research Fellowship, to MK). Grants to MY and JYK were administered by the Northern California Institute for Research and Education, and supported by resources of the Veterans Affairs Medical Center, San Francisco, California. NR 351 TC 33 Z9 36 U1 2 U2 23 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 0929-8673 EI 1875-533X J9 CURR MED CHEM JI Curr. Med. Chem. PD JUN PY 2014 VL 21 IS 18 BP 2076 EP 2097 PG 22 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA AF6UM UT WOS:000334850100006 PM 24372209 ER PT J AU Gin, JL Stein, JA Heslin, KC Dobalian, A AF Gin, June L. Stein, Judith A. Heslin, Kevin C. Dobalian, Aram TI Responding to risk: Awareness and action after the September 11, 2001 terrorist attacks SO SAFETY SCIENCE LA English DT Article DE Emergency preparedness; Terrorism; Social psychology; Pre-disposing factors; Disaster planning; Cognitive awareness ID INDIVIDUAL-RESPONSE; PREPAREDNESS; PERSPECTIVE; CANADA; HAZARD; STATES; MODEL AB Adoption of preparedness measures among the US public remains low after the expansion of the all-hazards approach to personal preparedness campaigns following the terrorist attacks of September 11, 2001 (9/11). This study sought to understand factors influencing preparedness behavior, particularly how demographics might influence preparedness behavior and whether preparedness actions are related to preparedness attitudes and related behaviors that may prime individuals to take these actions. Using data from the 2008 General Social Survey (n = 1338), we tested a conceptual path model of preparedness that includes demographic variables and three latent variables as mediators of the effects of demographics on preparedness: Cognitive Preparedness; Peer Group Behavior Awareness, and Perceived Effectiveness. The model explains 65% of the variance in preparedness behavior. It suggests that the effects of demographic factors on preparedness actually reflect indirect relationships mediated by predisposing attitudes, behaviors and experiences, specifically, Cognitive Preparedness, Peer Group Behavior Awareness, and Perceived Effectiveness that predispose individuals toward taking preparedness actions. Because these social and cognitive factors reflect behaviors that, unlike fixed demographics, can be shaped by public education programs, efforts to increase public preparedness should focus on improving public awareness, social networks, and more persuasive messaging as keys to increasing preparedness behavior among the US public. (C) 2014 The Authors. Published by Elsevier Ltd. All rights reserved. C1 [Gin, June L.; Stein, Judith A.; Heslin, Kevin C.; Dobalian, Aram] US Dept Vet Affairs, Vet Emergency Management Evaluat Ctr, North Hills, CA 91343 USA. [Heslin, Kevin C.; Dobalian, Aram] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Hlth Policy & Management, Los Angeles, CA 90024 USA. [Dobalian, Aram] UCLA Sch Nursing, Los Angeles, CA USA. RP Gin, JL (reprint author), US Dept Vet Affairs, Vet Emergency Management Evaluat Ctr, 16111 Plummer St,MS-152, North Hills, CA 91343 USA. EM june.gin@va.gov; jastein@ucla.edu; kevin.heslin@va.gov; aram.dobalian@va.gov FU US Department of Veterans Affairs, Veterans Health Administration, Office of Public Health FX This material is based on work supported by the US Department of Veterans Affairs, Veterans Health Administration, Office of Public Health. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the US Department of Veterans Affairs or the US government. The authors thank Michael N. Mitchell for statistical consulting assistance provided on the GSS data set. NR 35 TC 1 Z9 2 U1 3 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-7535 EI 1879-1042 J9 SAFETY SCI JI Saf. Sci. PD JUN PY 2014 VL 65 BP 86 EP 92 DI 10.1016/j.ssci.2014.01.001 PG 7 WC Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA AD8JQ UT WOS:000333512700011 ER PT J AU Rogers, T Milkman, KL Volpp, KG AF Rogers, Todd Milkman, Katherine L. Volpp, Kevin G. TI Commitment Devices Using Initiatives to Change Behavior SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID SMOKING-CESSATION C1 [Rogers, Todd] Harvard Univ, Kennedy Sch, Boston, MA 02115 USA. [Milkman, Katherine L.; Volpp, Kevin G.] Univ Penn, Wharton Sch, Ctr Hlth Incent & Behav Econ, Philadelphia, PA 19104 USA. [Volpp, Kevin G.] Univ Penn, Philadelphia VA Med Ctr, Perelman Sch Med, Ctr Hlth Incent & Behav Econ, Philadelphia, PA 19104 USA. RP Volpp, KG (reprint author), Univ Penn, Philadelphia VA Med Ctr, Perelman Sch Med, Ctr Hlth Incent & Behav Econ, 423 Guardian Dr,1120 Blockley Hall, Philadelphia, PA 19104 USA. EM volpp70@exchange.upenn.edu NR 7 TC 11 Z9 11 U1 2 U2 14 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 28 PY 2014 VL 311 IS 20 BP 2065 EP 2066 DI 10.1001/jama.2014.3485 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AH8MQ UT WOS:000336392400018 PM 24777472 ER PT J AU Cotton, PB Durkalski, V Romagnuolo, J Pauls, Q Fogel, E Tarnasky, P Aliperti, G Freeman, M Kozarek, R Jamidar, P Wilcox, M Serrano, J Brawman-Mintzer, O Elta, G Mauldin, P Thornhill, A Hawes, R Wood-Williams, A Orrell, K Drossman, D Robuck, P AF Cotton, Peter B. Durkalski, Valerie Romagnuolo, Joseph Pauls, Qi Fogel, Evan Tarnasky, Paul Aliperti, Giuseppe Freeman, Martin Kozarek, Richard Jamidar, Priya Wilcox, Mel Serrano, Jose Brawman-Mintzer, Olga Elta, Grace Mauldin, Patrick Thornhill, Andre Hawes, Robert Wood-Williams, April Orrell, Kyle Drossman, Douglas Robuck, Patricia TI Effect of Endoscopic Sphincterotomy for Suspected Sphincter of Oddi Dysfunction on Pain-Related Disability Following Cholecystectomy The EPISOD Randomized Clinical Trial SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; FUNCTIONAL GASTROINTESTINAL DISORDERS; FINDINGS TYPE-I; HEALTH-STATUS; RISK-FACTORS; DSM-IV; ERCP; GALLBLADDER; SYMPTOMS; DISEASE AB IMPORTANCE Abdominal pain after cholecystectomy is common and may be attributed to sphincter of Oddi dysfunction. Management often involves endoscopic retrograde cholangiopancreatography (ERCP) with manometry and sphincterotomy. OBJECTIVE To determine whether endoscopic sphincterotomy reduces pain and whether sphincter manometric pressure is predictive of pain relief. DESIGN, SETTING, AND PATIENTS Multicenter, sham-controlled, randomized trial involving 214 patients with pain after cholecystectomy without significant abnormalities on imaging or laboratory studies, and no prior sphincter treatment or pancreatitis randomly assigned (August 6, 2008-March 23, 2012) to undergo sphincterotomy or sham therapy at 7 referral medical centers. One-year follow-up was blinded. The final follow-up visit was March 21, 2013. INTERVENTIONS After ERCP, patients were randomized 2: 1 to sphincterotomy (n = 141) or sham (n = 73) irrespective of manometry findings. Those randomized to sphincterotomy with elevated pancreatic sphincter pressures were randomized again (1: 1) to biliary or to both biliary and pancreatic sphincterotomies. Seventy-two were entered into an observational study with conventional ERCP managemeny. MAIN OUTCOMES AND MEASURES Success of treatment was defined as less than 6 days of disability due to pain in the prior 90 days both at months 9 and 12 after randomization, with no narcotic use and no further sphincter intervention. RESULTS Twenty-seven patients (37%; 95% CI, 25.9%-48.1%) in the sham treatment group vs 32 (23%; 95% CI, 15.8%-29.6%) in the sphincterotomy group experienced successful treatment (adjusted risk difference, -15.6%; 95% CI, -28.0% to -3.3%; P =.01). Of the patients with pancreatic sphincter hypertension, 14 (30%; 95% CI, 16.7%-42.9%) who underwent dual sphincterotomy and 10 (20%; 95% CI, 8.7%-30.5%) who underwent biliary sphincterotomy alone experienced successful treatment. Thirty-seven treated patients (26%; 95% CI, 19%-34%) and 25 patients (34%; 95% CI, 23%-45%) in the sham group underwent repeat ERCP interventions (P =.22). Manometry results were not associated with the outcome. No clinical subgroups appeared to benefit from sphincterotomy more than others. Pancreatitis occurred in 15 patients (11%) after primary sphincterotomies and in 11 patients (15%) in the sham group. Of the nonrandomized patients in the observational study group, 5 (24%; 95% CI, 6%-42%) who underwent biliary sphincterotomy, 12 (31%; 95% CI, 16%-45%) who underwent dual sphincterotomy, and 2 (17%; 95% CI, 0%-38%) who did not undergo sphincterotomy had successful treatment. CONCLUSIONS AND RELEVANCE In patients with abdominal pain after cholecystectomy undergoing ERCP with manometry, sphincterotomy vs sham did not reduce disability due to pain. These findings do not support ERCP and sphincterotomy for these patients. C1 [Cotton, Peter B.; Durkalski, Valerie; Romagnuolo, Joseph; Pauls, Qi; Mauldin, Patrick; Thornhill, Andre; Hawes, Robert; Wood-Williams, April; Orrell, Kyle] Med Univ S Carolina, Charleston, SC 29425 USA. [Fogel, Evan] Indiana Univ, Indianapolis, IN 46204 USA. [Tarnasky, Paul] Dallas Med Ctr, Dallas, TX USA. [Aliperti, Giuseppe] Midwest Therapeut Endoscopy Consultants, St Louis, MO USA. [Freeman, Martin] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA. [Kozarek, Richard] Virginia Mason Med Ctr, Seattle, WA 98101 USA. [Jamidar, Priya] Yale Univ, New Haven, CT USA. [Wilcox, Mel] Univ Alabama Birmingham, Birmingham, AL USA. [Serrano, Jose; Robuck, Patricia] Natl Inst Diabet & Digest & Kidney Dis, Bethesda, MD USA. [Brawman-Mintzer, Olga] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Elta, Grace] Univ Michigan, Ann Arbor, MI 48109 USA. [Hawes, Robert] Florida Hosp, Orlando, FL USA. [Drossman, Douglas] Univ N Carolina, Chapel Hill, NC USA. [Drossman, Douglas] Drossman Gastroenterol PLLC, Chapel Hill, NC USA. RP Cotton, PB (reprint author), Med Univ S Carolina, Ctr Digest Dis, ART 7094,MSC 290,25 Courtenay Dr, Charleston, SC 29425 USA. EM cottonp@musc.edu FU National Institutes of Diabetes and Digestive and Kidney Diseases [U01 DK074739] FX This study was funded by grant U01 DK074739 from the National Institutes of Diabetes and Digestive and Kidney Diseases. NR 40 TC 40 Z9 41 U1 9 U2 16 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 28 PY 2014 VL 311 IS 20 BP 2101 EP 2109 DI 10.1001/jama.2014.5220 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AH8MQ UT WOS:000336392400026 PM 24867013 ER PT J AU Zhao, X Chen, F Feng, ZJ Li, XS Zhou, XH AF Zhao, Xing Chen, Fei Feng, Zijian Li, Xiaosong Zhou, Xiao-Hua TI Characterizing the effect of temperature fluctuation on the incidence of malaria: an epidemiological study in south-west China using the varying coefficient distributed lag non-linear model SO MALARIA JOURNAL LA English DT Article ID DENGUE VIRUS TRANSMISSION; EAST-AFRICAN HIGHLANDS; METEOROLOGICAL FACTORS; YUNNAN PROVINCE; SPATIOTEMPORAL DISTRIBUTION; PLASMODIUM-FALCIPARUM; CLIMATE-CHANGE; AEDES-AEGYPTI; ASSOCIATION; RISK AB Background: Malaria transmission is strongly determined by the environmental temperature and the environment is rarely constant. Therefore, mosquitoes and parasites are not only exposed to the mean temperature, but also to daily temperature variation. Recently, both theoretical and laboratory work has shown, in addition to mean temperatures, daily fluctuations in temperature can affect essential mosquito and parasite traits that determine malaria transmission intensity. However, so far there is no epidemiological evidence at the population level to this problem. Methods: Thirty counties in southwest China were selected, and corresponding weekly malaria cases and weekly meteorological variables were collected from 2004 to 2009. Particularly, maximum, mean and minimum temperatures were collected. The daily temperature fluctuation was measured by the diurnal temperature range (DTR), the difference between the maximum and minimum temperature. The distributed lag non-linear model (MDLNM) was used to study the correlation between weekly malaria incidences and weekly mean temperatures, and the correlation pattern was allowed to vary over different levels of daily temperature fluctuations. Results: The overall non-linear patterns for mean temperatures are distinct across different levels of DTR. When under cooler temperature conditions, the larger mean temperature effect on malaria incidences is found in the groups of higher DTR, suggesting that large daily temperature fluctuations act to speed up the malaria incidence in cooler environmental conditions. In contrast, high daily fluctuations under warmer conditions will lead to slow down the mean temperature effect. Furthermore, in the group of highest DTR, 24-25 degrees C or 21-23 degrees C are detected as the optimal temperature for the malaria transmission. Conclusion: The environment is rarely constant, and the result highlights the need to consider temperature fluctuations as well as mean temperatures, when trying to understand or predict malaria transmission. This work may be the first epidemiological study confirming that the effect of the mean temperature depends on temperature fluctuations, resulting in relevant evidence at the population level. C1 [Zhao, Xing; Chen, Fei; Li, Xiaosong] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Peoples R China. [Zhao, Xing; Zhou, Xiao-Hua] Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA. [Feng, Zijian] Chinese Ctr Dis Control & Prevent, Off Dis Control & Emergency Response, Beijing 102206, Peoples R China. [Zhou, Xiao-Hua] VA Puget Sound Hlth Care Syst, HSR&D Ctr Excellence, Seattle, WA 98101 USA. RP Li, XS (reprint author), Sichuan Univ, West China Sch Publ Hlth, 17 Sect 3,South Renmin Rd, Chengdu 610041, Peoples R China. EM lixiaosong1101@126.com; azhou@u.washington.edu FU Natural Science Foundation of China, China Scholarship Council [30571618] FX The three reviewers' comments have greatly improved the content and readability of the manuscript. The Figure in the Additional file 1 was reproduced from a previous article written by same authors [35], and the Figure was included for the purpose of completeness. In addition, Table 1, with some new data, was partly reproduced from that previous article. This study was supported by the Natural Science Foundation of China (No. 30571618), China Scholarship Council (http://en.csc.edu.cn/). NR 45 TC 5 Z9 5 U1 3 U2 14 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 27 PY 2014 VL 13 AR 192 DI 10.1186/1475-2875-13-192 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AL2JC UT WOS:000338950900003 PM 24886630 ER PT J AU Kunchithapautham, K Atkinson, C Rohrer, B AF Kunchithapautham, Kannan Atkinson, Carl Rohrer, Baerbel TI Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID UNFOLDED PROTEIN RESPONSE; FACTOR-H POLYMORPHISM; MACULAR DEGENERATION; CIGARETTE-SMOKE; BRUCHS MEMBRANE; CHOROIDAL NEOVASCULARIZATION; REGULATORY PROTEINS; ALTERNATIVE PATHWAY; GEOGRAPHIC ATROPHY; APOLIPOPROTEIN-E AB Age-related macular degeneration (AMD) is a complex disease caused by genetic and environmental factors, including genetic variants in complement components and smoking. Smoke exposure leads to oxidative stress, complement activation, endoplasmic reticulum (ER) stress, and lipid dysregulation, which have all been proposed to be associated with AMD pathogenesis. Here we examine the effects of smoke exposure on the retinal pigment epithelium (RPE). Mice were exposed to cigarette smoke or filtered air for 6 months. RPE cells grown as stable monolayers were exposed to 5% cigarette smoke extract (CSE). Effects of smoke were determined by biochemical, molecular, and histological measures. Effects of the alternative pathway (AP) of complement and complement C3a anaphylatoxin receptor signaling were analyzed using knock-out mice or specific inhibitors. ER stress markers were elevated after smoke exposure in RPE of intact mice, which was eliminated in AP-deficient mice. To examine this relationship further, RPE monolayers were exposed to CSE. Short term smoke exposure resulted in production and release of complement C3, the generation of C3a, oxidative stress, complement activation on the cell membrane, and ER stress. Long term exposure to CSE resulted in lipid accumulation, and secretion. All measures were reversed by blocking C3a complement receptor (C3aR), alternative complement pathway signaling, and antioxidant therapy. Taken together, our results provide clear evidence that smoke exposure results in oxidative stress and complement activation via the AP, resulting in ER stress-mediated lipid accumulation, and further suggesting that oxidative stress and complement act synergistically in the pathogenesis of AMD. C1 [Kunchithapautham, Kannan; Rohrer, Baerbel] Med Univ S Carolina, Dept Ophthalmol, Charleston, SC 29425 USA. [Atkinson, Carl] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA. [Rohrer, Baerbel] Ralph H Johnson Vet Affairs Med Ctr, Res Serv, Charleston, SC 29401 USA. RP Rohrer, B (reprint author), 167 Ashley Ave, Charleston, SC 29425 USA. EM rohrer@musc.edu FU National Institutes of Health [C06RR015455] FX Animal studies were conducted in a facility constructed with support from the National Institutes of Health Grant C06RR015455. NR 78 TC 26 Z9 26 U1 1 U2 6 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD MAY 23 PY 2014 VL 289 IS 21 BP 14534 EP 14546 DI 10.1074/jbc.M114.564674 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AI9JE UT WOS:000337248100012 PM 24711457 ER PT J AU Ma, QL Zuo, XH Yang, FS Ubeda, OJ Gant, DJ Alaverdyan, M Kiosea, NC Nazari, S Chen, PP Nothias, F Chan, P Teng, E Frautschy, SA Cole, GM AF Ma, Qiu-Lan Zuo, Xiaohong Yang, Fusheng Ubeda, Oliver J. Gant, Dana J. Alaverdyan, Mher Kiosea, Nicolae C. Nazari, Sean Chen, Ping Ping Nothias, Fatiha Chan, Piu Teng, Edmond Frautschy, Sally A. Cole, Greg M. TI Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging SO JOURNAL OF NEUROSCIENCE LA English DT Article DE Alzheimer's disease; knock-out; MAPs; Morris Water Maze; synaptic markers; tau ID MICROTUBULE-ASSOCIATED PROTEIN; GLYCOGEN-SYNTHASE KINASE-3-BETA; ALPHA-LIPOIC ACID; ALZHEIMERS-DISEASE PATIENTS; MILD COGNITIVE IMPAIRMENT; N-TERMINAL KINASE; MOUSE MODEL; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION SITES; NEURONAL CYTOSKELETON AB Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood. We report that old (19 - 20 months; OKO) but not middle-aged (8 - 9 months; MKO) tau knock-out mice develop Morris Water Maze(MWM) deficits and loss of hippocampal acetylated alpha-tubulin and excitatory synaptic proteins. Mild motor deficits and reduction in tyrosine hydroxylase (TH) in the substantia nigra were present by middle age, but did not affect MWM performance, whereas OKO mice showed MWM deficits paralleling hippocampal deficits. Deletion of tau, a microtubule-associated protein (MAP), resulted in increased levels of MAP1A, MAP1B, and MAP2 in MKO, followed by loss of MAP2 and MAP1B in OKO. Hippocampal synaptic deficits in OKO mice were partially corrected with dietary supplementation with docosahexaenoic acid (DHA) and both MWM and synaptic deficits were fully corrected by combining DHA with alpha-lipoic acid (ALA), which also prevented TH loss. DHA or DHA/ALA restored phosphorylated and total GSK3 beta and attenuated hyperactivation of the tau C-Jun N-terminal kinases (JNKs) while increasing MAP1B, dephosphorylated (active) MAP2, and acetylated alpha-tubulin, suggesting improved microtubule stability and maintenance of active compensatory MAPs. Our results implicate the loss of MAP function in age-associated hippocampal deficits and identify a safe dietary intervention, rescuing both MAP function and TH in OKO mice. Therefore, in addition to microtubule-stabilizing therapeutic drugs, preserving or restoring compensatory MAP function may be a useful new prevention strategy. C1 [Ma, Qiu-Lan; Zuo, Xiaohong; Yang, Fusheng; Ubeda, Oliver J.; Gant, Dana J.; Alaverdyan, Mher; Kiosea, Nicolae C.; Nazari, Sean; Chen, Ping Ping; Teng, Edmond; Frautschy, Sally A.; Cole, Greg M.] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA. [Ma, Qiu-Lan; Zuo, Xiaohong; Yang, Fusheng; Ubeda, Oliver J.; Gant, Dana J.; Alaverdyan, Mher; Kiosea, Nicolae C.; Nazari, Sean; Chen, Ping Ping; Teng, Edmond; Frautschy, Sally A.; Cole, Greg M.] Greater Los Angeles Vet Affairs Healthcare Syst, Geriatr Res Educ & Clin Ctr, Los Angeles, CA 90073 USA. [Nothias, Fatiha] Univ Paris 06, CNRS, INSERM U952, Unite Mixte Rech 7224, F-75005 Paris, France. [Chan, Piu] Capital Med Univ, Xuanwu Hosp, Beijing Inst Geriatr, Dept Neurobiol & Neurol, Beijing 10053, Peoples R China. RP Cole, GM (reprint author), Vet Greater Los Angeles Healthcare, Mary S Easton Translat Ctr, 11301 Wilshire Blvd,Bldg 113,Rm 312, Los Angeles, CA 90073 USA. EM frautsch@ucla.edu; gmcole@ucla.edu RI Zuo, Xiaohong/H-6254-2016 FU National Institutes of Health [AT003008]; Alzheimer's Disease Research Center [P01AG16570, RC1AG035878, AG13471, U01 28583, R01AG021975]; Alzheimer's Association [NIRG-07-59659]; UCLA Alzheimer's Disease Research Center Mary S. Easton Drug Discovery Program; UCLA Mary S. Easton Translational Center; Beijing High Standard Health Human Resource Cultural Program [e1e12] FX This work was supported by the National Institutes of Health (Grant AT003008 to G. M. C.; Grant P01AG16570 from the Alzheimer's Disease Research Center to G. M. C.; Grant RC1AG035878 to G. M. C. and S. A. F.; Grant AG13471 to G. M. C.; Grant U01 28583 to S. A. F.; and Grant R01AG021975 to S. A. F.), the Alzheimer's Association (Grant NIRG-07-59659 to Q. L. M.), the UCLA Alzheimer's Disease Research Center Mary S. Easton Drug Discovery Program (G. M. C.), the UCLA Mary S. Easton Translational Center (G. M. C., S. A. F.), and David and Dr. Sharon Comden (S. A. F., G. M. C.). X.Z. was supported by the Beijing High Standard Health Human Resource Cultural Program (Grant e1e12 to P. P. C.). The polyclonal antibody to dephosphorylated, active MAP2 "MAP2 972" was provided by Jesus Avila, PhD (Professor, Universidad Autonoma de Madrid, Spain). NR 80 TC 28 Z9 29 U1 0 U2 9 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD MAY 21 PY 2014 VL 34 IS 21 BP 7124 EP 7136 DI 10.1523/JNEUROSCI.3439-13.2014 PG 13 WC Neurosciences SC Neurosciences & Neurology GA AI5HB UT WOS:000336895200010 PM 24849348 ER PT J AU Volpp, KG AF Volpp, Kevin G. TI The Counseling African Americans to Control Hypertension Study and Ways to Enhance the Next Wave of Behavioral Interventions SO CIRCULATION LA English DT Editorial Material DE Editorials; hypertension; intervention studies; medication adherence ID DEFAULT OPTIONS; CARE C1 [Volpp, Kevin G.] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. [Volpp, Kevin G.] Univ Penn, Wharton Sch, Perelman Sch Med, Philadelphia, PA 19104 USA. [Volpp, Kevin G.] Univ Penn, Ctr Hlth Incent & Behav Econ, Philadelphia, PA 19104 USA. RP Volpp, KG (reprint author), Univ Penn, Dept Med, 1120 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM volpp70@wharton.upenn.edu NR 12 TC 1 Z9 1 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD MAY 20 PY 2014 VL 129 IS 20 BP 2002 EP 2004 DI 10.1161/CIRCULATIONAHA.114.009409 PG 3 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AI6KA UT WOS:000336981400007 PM 24657990 ER PT J AU Alumkal, JJ Heiser, L Beer, TM Small, EJ Baertsch, R Stuart, J King, C Korkola, J Cetnar, J Graff, JN Thomas, G Ryan, CW Toschi, A Youngren, J Tucker, E Ellers, K AF Alumkal, Joshi J. Heiser, Laura Beer, Tomasz M. Small, Eric Jay Baertsch, Robert Stuart, Josh King, Carly Korkola, James Cetnar, Jeremy Graff, Julie Nicole Thomas, George Ryan, Christopher W. Toschi, Alexandria Youngren, Jack Tucker, Erin Ellers, Kristi CA AACR PCF Stand Up Canc West Coast TI Identifying enzalutamide resistance mechanisms in men with castration-resistant prostate cancer. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Oregon Hlth & Sci Univ, OHSU Knight Canc Inst, Portland, OR 97201 USA. Oregon Hlth & Sci Univ, Portland, OR 97201 USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA. Oregon Hlth & Sci Univ, Knight Canc Inst, Portland VA Med Ctr, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA TPS5104 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613202141 ER PT J AU Fisher, M Yim, YM Small, A Luthra, R Singer, J Schukman, J McAneny, BL Punekar, R Malin, J AF Fisher, Maxine Yim, Yeun Mi Small, Art Luthra, Rakesh Singer, Joseph Schukman, Jay McAneny, Barbara L. Punekar, Rajeshjwari Malin, Jennifer TI Comparative health care (HC) costs and quality of care in five cancer types by physician office (PO) and hospital outpatient (HOP) settings SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 HealthCore Inc, Wilmington, DE USA. Genentech Inc, San Francisco, CA 94080 USA. WellPoint Inc, Indianapolis, IN USA. New Mexico Oncol Hematol Consultants LTD, Albuquerque, NM USA. VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA 6528 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613203714 ER PT J AU Friedlander, TW Premasekharan, G Ngo, V Hang, E Graff, JN Ryan, CJ Paris, P AF Friedlander, Terence W. Premasekharan, Gayatri Ngo, Vy Hang, Evelyn Graff, Julie Nicole Ryan, Charles J. Paris, Pamela TI Molecular and genomic characterization of invasive circulating tumor cells (iCTCs) from men with metastatic castration-resistant prostate cancer (mCRPC). SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Univ Calif San Francisco, San Francisco, CA 94143 USA. Univ Calif San Francisco, Med Ctr, San Francisco, CA USA. Oregon Hlth & Sci Univ, Knight Canc Inst, Portland VA Med Ctr, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA 11013 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613204746 ER PT J AU Matro, JM Yu, JQ Heinrich, MC Ramachandran, A Ku, N von Mehren, M AF Matro, Jennifer Madeline Yu, Jian Qin Heinrich, Michael C. Ramachandran, Abhijit Ku, Nora von Mehren, Margaret TI Correlation of PET/CT and CT RECIST response in GIST patients with PDGFRA D842V gene mutations treated with crenolanib. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. OHSU Knight Canc Inst, Portland, OR USA. Portland VA Med Ctr, Portland, OR USA. AROG Pharmaceut LLC, Dallas, TX USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA 10546 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613204679 ER PT J AU Moghanaki, D Cheuk, AV Fosmire, H Anscher, MS Hagan, MP Lutz, ST Dawson, GA AF Moghanaki, Drew Cheuk, Alice V. Fosmire, Helen Anscher, Mitchell Steven Hagan, Michael Philip Lutz, Stephen T. Dawson, George A. TI Availability of single-fraction palliative radiotherapy for cancer patients receiving end-of-life care within the Veterans Healthcare Administration. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Hunter Holmes McGuire Vet Affairs Med Ctr, Richmond, VA USA. James J Peters VA Med Ctr, New York, NY USA. Richard L Roudebush Vet Affairs Med Ctr, Indianapolis, IN 46202 USA. Virginia Commonwealth Univ, Med Ctr, Richmond, VA USA. US Dept Vet Affairs, Natl Radiat Oncol Program, Richmond, VA USA. Blanchard Valley Reg Hlth Ctr, Findlay, OH USA. VA New Jersey Healthcare Syst, E Orange, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA 9556 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613204440 ER PT J AU Nannini, M Astolfi, A Urbini, M Indio, V Santini, D Heinrich, MC Corless, CL Saponara, M Mandrioli, A Lolli, C Ercolani, G Biasco, G Pantaleo, MA AF Nannini, Margherita Astolfi, Annalisa Urbini, Milena Indio, Valentina Santini, Donatella Heinrich, Michael C. Corless, Christopher L. Saponara, Maristella Mandrioli, Anna Lolli, Cristian Ercolani, Giorgio Biasco, Guido Pantaleo, Maria A. TI Integrate whole genomic study of KIT/PDGFRA wild-type (WT) GIST. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Univ Bologna, St Orsola Malpighi Hosp, Dept Specialized Expt & Diagnost Med, Bologna, Italy. Univ Bologna, Giorgio Prodi Canc Res Ctr, Bologna, Italy. Univ Bologna, S Orsola Malpighi Hosp, Pathol Unit, Bologna, Italy. OHSU Knight Canc Inst, Portland, OR USA. Portland VA Med Ctr, Portland, OR USA. Oregon Hlth & Sci Univ, Knight Diagnost Labs, Portland, OR 97201 USA. St Orsola Marcello Malpighi Hosp, Liver & Multiorgan Transplant Unit, Bologna, Italy. Univ Bologna, L&A Seragnoli Dept Hematol & Oncol Sci, Bologna, Italy. RI Saponara, Maristella/J-9904-2016; Urbini, Milena/K-1351-2016; nannini, margherita/J-9866-2016 OI Saponara, Maristella/0000-0003-0715-171X; Urbini, Milena/0000-0002-3364-9098; NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA 10513 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613204646 ER PT J AU Peled, N Abud-Hawa, M Liran, O Ilouze, M Gai-Mor, N Shlomi, D Ben-Nun, A Onn, A Bar, J Johnson, D Wells, J Millstone, S Bunn, PA Miller, YE Keith, RL Rikke, B Hirsch, FR Haick, H AF Peled, Nir Abud-Hawa, Manal Liran, Ori Ilouze, Maya Gai-Mor, Naomi Shlomi, Dekel Ben-Nun, Alon Onn, Amir Bar, Jair Johnson, Douglas Wells, John Millstone, Stuart Bunn, Paul A. Miller, York E. Keith, Robert L. Rikke, Brad Hirsch, Fred R. Haick, Hossam TI Breath analysis as a noninvasive biomarker for early detection of lung cancer. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Rabin Med Ctr, Davidoff Canc Ctr, Thorac Canc Unit, Petach Tikwa, Israel. Technion Israel Inst Technol, Dept Chem Engn, IL-32000 Haifa, Israel. Technion Israel Inst Technol, Russell Berrie Nanotechnol Inst, Haifa, Israel. Chaim Sheba Med Ctr, Thorac Canc Res & Detect Ctr, Ramat Gan, Israel. Chaim Sheba Med Ctr, Inst Oncol, Thorac Oncol Unit, Ramat Gan, Israel. Chaim Sheba Med Ctr, Inst Oncol, Ramat Gan, Israel. Florida Radiat Oncol Grp, Jacksonville, FL USA. Univ Colorado, Ctr Canc, Aurora, CO USA. Univ Colorado, Ctr Canc, Denver, CO 80262 USA. Denver VA Med Ctr, Denver, CO USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA 7560 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613204018 ER PT J AU Wong, ML Wang, S Shi, Y Wozniak, CJ Walter, LC AF Wong, Melisa L. Wang, Sunny Shi, Ying Wozniak, Curtis J. Walter, Louise C. TI Impact of comorbidity and age on survival among older veterans with early stage non-small cell lung cancer (NSCLC). SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Univ Calif San Francisco, San Francisco, CA 94143 USA. San Francisco VA Med Ctr, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA 7540 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613203976 ER PT J AU Riar, AK Narasimhan, M Rathinam, ML Vedpathak, D Mummidi, S Henderson, GI Mahimainathan, L AF Riar, Amanjot Kaur Narasimhan, Madhusudhanan Rathinam, Mary Latha Vedpathak, Dhanashree Mummidi, Srinivas Henderson, George I. Mahimainathan, Lenin TI Ethanol-Induced Transcriptional Activation of Programmed Cell Death 4 (Pdcd4) Is Mediated by GSK-3 beta Signaling in Rat Cortical Neuroblasts SO PLOS ONE LA English DT Article ID FETAL ALCOHOL SYNDROME; TUMOR-SUPPRESSOR PDCD4; GLYCOGEN-SYNTHASE KINASE-3; BREAST-CANCER CELLS; NF-KAPPA-B; GENE-EXPRESSION; BETA-CATENIN; PRENATAL EXPOSURE; TRANSLATION INITIATION; PROTEIN TRANSLATION AB Ingestion of ethanol (ETOH) during pregnancy induces grave abnormalities in developing fetal brain. We have previously reported that ETOH induces programmed cell death 4 (PDCD4), a critical regulator of cell growth, in cultured fetal cerebral cortical neurons (PCNs) and in the cerebral cortex in vivo and affect protein synthesis as observed in Fetal Alcohol Spectrum Disorder (FASD). However, the mechanism which activates PDCD4 in neuronal systems is unclear and understanding this regulation may provide a counteractive strategy to correct the protein synthesis associated developmental changes seen in FASD. The present study investigates the molecular mechanism by which ethanol regulates PDCD4 in cortical neuroblasts, the immediate precursor of neurons. ETOH treatment significantly increased PDCD4 protein and transcript expression in spontaneously immortalized rat brain neuroblasts. Since PDCD4 is regulated at both the post-translational and post-transcriptional level, we assessed ETOH's effect on PDCD4 protein and mRNA stability. Chase experiments demonstrated that ETOH does not significantly impact either PDCD4 protein or mRNA stabilization. PDCD4 promoter-reporter assays confirmed that PDCD4 is transcriptionally regulated by ETOH in neuroblasts. Given a critical role of glycogen synthase kinase 3 beta (GSK-3 beta) signaling in regulating protein synthesis and neurotoxic mechanisms, we investigated the involvement of GSK-3 beta and showed that multifunctional GSK-3 beta was significantly activated in response to ETOH in neuroblasts. In addition, we found that ETOH-induced activation of PDCD4 was inhibited by pharmacologic blockade of GSK-3 beta using inhibitors, lithium chloride (LiCl) and SB-216763 or siRNA mediated silencing of GSK-3 beta. These results suggest that ethanol transcriptionally upregulates PDCD4 by enhancing GSK-3 beta signaling in cortical neuroblasts. Further, we demonstrate that canonical Wnt-3a/GSK-3 beta signaling is involved in regulating PDCD4 protein expression. Altogether, we provide evidence that GSK-3 beta/PDCD4 network may represent a critical modulatory point to manage the protein synthetic anomalies and growth aberrations of neural cells seen in FASD. C1 [Riar, Amanjot Kaur; Narasimhan, Madhusudhanan; Rathinam, Mary Latha; Vedpathak, Dhanashree; Henderson, George I.; Mahimainathan, Lenin] Texas Tech Univ, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Lubbock, TX 79409 USA. [Narasimhan, Madhusudhanan; Henderson, George I.; Mahimainathan, Lenin] Texas Tech Univ, Hlth Sci Ctr, South Plains Alcohol & Addict Res Ctr, Lubbock, TX 79409 USA. [Mummidi, Srinivas] South Texas Vet Hlth Care Syst, Ctr Personalized Med, San Antonio, TX USA. [Mummidi, Srinivas] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Mahimainathan, L (reprint author), Texas Tech Univ, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Lubbock, TX 79409 USA. EM lenin.mahimainathan@ttuhsc.edu FU National Institutes of Health Research Project Grant Program [RO1 AA010114]; Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development [1I01BX000975]; NIH [RO1AI043279] FX This work was supported by RO1 AA010114 (National Institutes of Health Research Project Grant Program) to George I. Henderson. SM is supported by grants awarded by the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development (1I01BX000975) and by RO1AI043279 (NIH). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 78 TC 3 Z9 3 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 16 PY 2014 VL 9 IS 5 AR e98080 DI 10.1371/journal.pone.0098080 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AM1NZ UT WOS:000339614800102 PM 24837604 ER PT J AU Chen, W McRoberts, JA Marvizon, JCG AF Chen, W. McRoberts, J. A. Marvizon, J. C. G. TI mu-OPIOID RECEPTOR INHIBITION OF SUBSTANCE P RELEASE FROM PRIMARY AFFERENTS DISAPPEARS IN NEUROPATHIC PAIN BUT NOT INFLAMMATORY PAIN SO NEUROSCIENCE LA English DT Article DE inflammation; internalization; opioid receptor; neurokinin 1 receptor; neuropathic pain; substance P ID RAT SPINAL-CORD; ROOT GANGLION NEURONS; DORSAL-HORN NEURONS; SRC FAMILY KINASES; METHYL-D-ASPARTATE; G-PROTEIN; NEUROKININ-1 RECEPTOR; GABA(B) RECEPTORS; NMDA RECEPTORS; ANTINOCICEPTIVE EFFICACY AB Opiate analgesia in the spinal cord is impaired during neuropathic pain. We hypothesized that this is caused by a decrease in mu-opioid receptor inhibition of neurotransmitter release from primary afferents. To investigate this possibility, we measured substance P release in the spinal dorsal horn as neurokinin 1 receptor (NK1R) internalization in rats with chronic constriction injury (CCI) of the sciatic nerve. Noxious stimulation of the paw with CCI produced inconsistent NK1R internalization, suggesting that transmission of nociceptive signals by the injured nerve was variably impaired after CCI. This idea was supported by the fact that CCI produced only small changes in the ability of exogenous substance P to induce NK1R internalization or in the release of substance P evoked centrally from site of nerve injury. In subsequent experiments, NK1R internalization was induced in spinal cord slices by stimulating the dorsal root ipsilateral to CCI. We observed a complete loss of the inhibition of substance P release by the mu-opioid receptor agonist [D-Ala(2), NMe-Phe(4), Gly-ol(5)]-enkephalin (DAMGO) in CCI rats but not in sham-operated rats. In contrast, DAMGO still inhibited substance P release after inflammation of the hind paw with complete Freund's adjuvant and in native rats. This loss of inhibition was not due to l-opioid receptor downregulation in primary afferents, because their colocalization with substance P was unchanged, both in dorsal root ganglion neurons and primary afferent fibers in the dorsal horn. In conclusion, nerve injury eliminates the inhibition of substance P release by l-opioid receptors, probably by hindering their signaling mechanisms. Published by Elsevier Ltd. on behalf of IBRO. C1 [Chen, W.; McRoberts, J. A.; Marvizon, J. C. G.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. [Chen, W.; McRoberts, J. A.; Marvizon, J. C. G.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Digest Dis, Los Angeles, CA 90095 USA. RP Marvizon, JCG (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Bldg 115,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM marvizon@ucla.edu FU Rehabilitation Research & Development Service, Department of Veterans Affairs, USA [1I01RX000378]; National Institute of Drug Abuse, USA [R01-DA033059] FX Supported by grants 1I01RX000378 from the Rehabilitation Research & Development Service, Department of Veterans Affairs, USA, to J.C.M. and R01-DA033059 from the National Institute of Drug Abuse, USA, to J.C.M and J.A.M. This study was done under the umbrella of the following UCLA institutes: Brain Research Institute, CURE: Digestive Diseases Research Center and the Oppenheimer Family Center for Neurobiology of Stress. We thank Wendy Walwyn for her valuable advice. The authors declare no competing financial interests. NR 79 TC 7 Z9 10 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4522 EI 1873-7544 J9 NEUROSCIENCE JI Neuroscience PD MAY 16 PY 2014 VL 267 BP 67 EP 82 DI 10.1016/j.neuroscience.2014.02.023 PG 16 WC Neurosciences SC Neurosciences & Neurology GA AF0KM UT WOS:000334402700007 PM 24583035 ER PT J AU Afdhal, N Zeuzem, S Kwo, P Chojkier, M Gitlin, N Puoti, M Romero-Gomez, M Zarski, JP Agarwal, K Buggisch, P Foster, GR Brau, N Buti, M Jacobson, IM Subramanian, GM Ding, X Mo, HM Yang, JC Pang, PS Symonds, WT McHutchison, JG Muir, AJ Mangia, A Marcellin, P AF Afdhal, Nezam Zeuzem, Stefan Kwo, Paul Chojkier, Mario Gitlin, Norman Puoti, Massimo Romero-Gomez, Manuel Zarski, Jean-Pierre Agarwal, Kosh Buggisch, Peter Foster, Graham R. Braeu, Norbert Buti, Maria Jacobson, Ira M. Subramanian, G. Mani Ding, Xiao Mo, Hongmei Yang, Jenny C. Pang, Phillip S. Symonds, William T. McHutchison, John G. Muir, Andrew J. Mangia, Alessandra Marcellin, Patrick CA ION-1 Investigators TI Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID CHRONIC HEPATITIS-C; VIRUS-INFECTION; THERAPY; COMBINATION; BOCEPREVIR; TELAPREVIR; RIBAVIRIN; CIRRHOSIS; TRIAL AB BACKGROUND In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection. METHODS We conducted a phase 3, open-label study involving previously untreated patients with chronic HCV genotype 1 infection. Patients were randomly assigned in a 1:1:1:1 ratio to receive ledipasvir and sofosbuvir in a fixed-dose combination tablet once daily for 12 weeks, ledipasvir-sofosbuvir plus ribavirin for 12 weeks, ledipasvir-sofosbuvir for 24 weeks, or ledipasvir-sofosbuvir plus ribavirin for 24 weeks. The primary end point was a sustained virologic response at 12 weeks after the end of therapy. RESULTS Of the 865 patients who underwent randomization and were treated, 16% had cirrhosis, 12% were black, and 67% had HCV genotype 1a infection. The rates of sustained virologic response were 99% (95% confidence interval [CI], 96 to 100) in the group that received 12 weeks of ledipasvir-sofosbuvir; 97% (95% CI, 94 to 99) in the group that received 12 weeks of ledipasvir-sofosbuvir plus ribavirin; 98% (95% CI, 95 to 99) in the group that received 24 weeks of ledipasvir-sofosbuvir; and 99% (95% CI, 97 to 100) in the group that received 24 weeks of ledipasvir-sofosbuvir plus ribavirin. No patient in either 12-week group discontinued ledipasvir-sofosbuvir owing to an adverse event. The most common adverse events were fatigue, headache, insomnia, and nausea. CONCLUSIONS Once-daily ledipasvir-sofosbuvir with or without ribavirin for 12 or 24 weeks was highly effective in previously untreated patients with HCV genotype 1 infection. C1 [Afdhal, Nezam] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Zeuzem, Stefan] Goethe Univ Frankfurt, Med Ctr, D-60054 Frankfurt, Germany. [Buggisch, Peter] Asklepios Klin St Georg, Inst Interdisziplinare Med Studien, Hamburg, Germany. [Kwo, Paul] Indiana Univ Sch Med, Indianapolis, IN 46202 USA. [Chojkier, Mario] Univ Calif San Diego, Med Ctr, San Diego, CA 92103 USA. [Subramanian, G. Mani; Ding, Xiao; Mo, Hongmei; Yang, Jenny C.; Pang, Phillip S.; Symonds, William T.; McHutchison, John G.] Gilead Sci, Foster City, CA USA. [Gitlin, Norman] Atlanta Gastroenterol Associates, Atlanta, GA USA. [Puoti, Massimo] Azienda Osped Osped Niguarda Ca Granda, Milan, Italy. [Mangia, Alessandra] Casa Sollievo Sofferenza Hosp, San Giovanni Rotondo, Italy. [Romero-Gomez, Manuel] Hosp Univ Nuestra Senora de Valme, Seville, Spain. [Buti, Maria] Hosp Univ Vall dHebron, Barcelona, Spain. [Buti, Maria] Ciberhed, Inst Carlos 3, Barcelona, Spain. [Zarski, Jean-Pierre] CHU Grenoble, F-38043 Grenoble, France. [Marcellin, Patrick] Hop Beaujon, F-92110 Clichy, France. [Agarwal, Kosh] Kings Coll Hosp London, Inst Liver Studies, London SE5 8RX, England. [Foster, Graham R.] Queen Mary Univ London, London, England. [Braeu, Norbert] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. [Jacobson, Ira M.] Weill Cornell Med Coll, New York, NY USA. [Muir, Andrew J.] Duke Univ, Med Ctr, Durham, NC USA. RP Afdhal, N (reprint author), Beth Israel Deaconess Med Ctr, 110 Francis St,Suite 4, Boston, MA 02215 USA. EM nafdhal@bidmc.harvard.edu; patrick.marcellin@bjn.ap-hop-paris.fr RI Romero Gomez, Manuel/L-8030-2014; IBIS, DIGESTIVAS/O-1913-2015 OI Davis, Mitchell/0000-0002-0526-5564; ANDREONE, PIETRO/0000-0002-4794-9809 FU Gilead Sciences FX Supported by Gilead Sciences. NR 21 TC 630 Z9 644 U1 7 U2 46 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAY 15 PY 2014 VL 370 IS 20 BP 1889 EP 1898 DI 10.1056/NEJMoa1402454 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AH4UH UT WOS:000336123600005 PM 24725239 ER PT J AU Lim, JK Tate, JP Fultz, SL Goulet, JL Conigliaro, J Bryant, KJ Gordon, AJ Gibert, C Rimland, D Goetz, MB Klein, MB Fiellin, DA Justice, AC Lo Re, V AF Lim, Joseph K. Tate, Janet P. Fultz, Shawn L. Goulet, Joseph L. Conigliaro, Joseph Bryant, Kendall J. Gordon, Adam J. Gibert, Cynthia Rimland, David Goetz, Matthew Bidwell Klein, Marina B. Fiellin, David A. Justice, Amy C. Lo Re, Vincent, III TI Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus-Infected, and Uninfected Patients SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE alcohol; liver fibrosis; HIV; hepatitis C; FIB-4 ID VETERANS AGING COHORT; PLATELET RATIO INDEX; PREDICTING LIVER FIBROSIS; SUBSTANCE USE DISORDERS; ASPARTATE-AMINOTRANSFERASE; PSYCHIATRIC-DIAGNOSIS; SAMPLING VARIABILITY; CIRRHOSIS; VALIDATION; TESTS AB Background. It is unclear if the risk of liver disease associated with different levels of alcohol consumption is higher for patients infected with human immunodeficiency virus (HIV) or chronic hepatitis C virus (HCV). We evaluated associations between alcohol use categories and advanced hepatic fibrosis, by HIV and chronic HCV status. Methods. We performed a cross-sectional study among participants in the Veterans Aging Cohort Study who reported alcohol consumption at enrollment (701 HIV/HCV-coinfected; 1410 HIV-monoinfected; 296 HCV-monoinfected; 1158 HIV/HCV-uninfected). Alcohol use category was determined by the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaire and alcohol-related diagnoses and was classified as nonhazardous drinking, hazardous/binge drinking, or alcohol-related diagnosis. Advanced hepatic fibrosis was defined by FIB-4 index >3.25. Results. Within each HIV/HCV group, the prevalence of advanced hepatic fibrosis increased as alcohol use category increased. For each alcohol use category, advanced hepatic fibrosis was more common among HIV-infected than uninfected (nonhazardous: 6.7% vs 1.4%; hazardous/binge: 9.5% vs 3.0%; alcohol-related diagnosis: 19.0% vs 8.6%; P < .01) and chronic HCV-infected than uninfected (nonhazardous: 13.6% vs 2.5%; hazardous/binge: 18.2% vs 3.1%; alcohol-related diagnosis: 22.1% vs 6.5%; P < .01) participants. Strong associations with advanced hepatic fibrosis (adjusted odds ratio [95% confidence interval]) were observed among HIV/HCV-coinfected patients with nonhazardous drinking (14.2 [5.91-34.0]), hazardous/binge drinking (18.9 [7.98-44.8]), and alcohol-related diagnoses (25.2 [10.6-59.7]) compared with uninfected nonhazardous drinkers. Conclusions. Advanced hepatic fibrosis was present at low levels of alcohol consumption, increased with higher alcohol use categories, and was more prevalent among HIV-infected and chronic HCV-infected patients than uninfected individuals. All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV/HCV-coinfected patients. C1 [Lim, Joseph K.; Tate, Janet P.; Goulet, Joseph L.; Justice, Amy C.] Vet Affairs VA Connecticut Healthcare Syst, West Haven, CT USA. [Lim, Joseph K.; Tate, Janet P.; Goulet, Joseph L.; Fiellin, David A.; Justice, Amy C.] Yale Univ, Sch Med, New Haven, CT USA. [Fultz, Shawn L.] US FDA, Ctr Tobacco Prod, Washington, DC 20204 USA. Hofstra North Shore LIJ Sch Med, Lake Success, NY USA. [Conigliaro, Joseph] North Shore LIJ Hlth Syst, Lake Success, NY USA. [Bryant, Kendall J.] NIAAA, Bethesda, MD USA. [Gordon, Adam J.] Univ Pittsburgh, Pittsburgh, PA 15260 USA. [Gordon, Adam J.] Pittsburgh VA Med Ctr, Pittsburgh, PA USA. [Gibert, Cynthia] VA Med Ctr, Washington, DC USA. [Gibert, Cynthia] George Washington Univ, Med Ctr, Washington, DC 20037 USA. [Rimland, David] Atlanta VA Med Ctr, Atlanta, GA USA. [Rimland, David] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Goetz, Matthew Bidwell] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Goetz, Matthew Bidwell] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Klein, Marina B.] McGill Univ, Ctr Hlth, Chron Viral Illness Serv, Montreal, PQ, Canada. [Fiellin, David A.; Justice, Amy C.] Yale Univ, Sch Publ Hlth, Yale Ctr Interdisciplinary Res AIDS, New Haven, CT USA. [Lo Re, Vincent, III] Univ Penn, Philadelphia VA Med Ctr, Philadelphia, PA 19104 USA. [Lo Re, Vincent, III] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. RP Lo Re, V (reprint author), Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, 836 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM vincentl@mail.med.upenn.edu RI Lo Re, Vincent/N-7817-2015 OI Goetz, Matthew/0000-0003-4542-992X; Fiellin, David/0000-0002-4006-010X; Goulet, Joseph/0000-0002-0842-804X FU National Institute on Alcohol Abuse and Alcoholism [U01 AA13566, R21 AA015894]; National Institute of Allergy and Infectious Diseases [K01 AI070001] FX This study was supported by the National Institute on Alcohol Abuse and Alcoholism (grant numbers U01 AA13566 to A. C. J. and R21 AA015894 to J. K. L and A. C. J.) and the National Institute of Allergy and Infectious Diseases (grant number K01 AI070001 to V. L. R.). NR 60 TC 16 Z9 16 U1 1 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 15 PY 2014 VL 58 IS 10 BP 1449 EP 1458 DI 10.1093/cid/ciu097 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH3RZ UT WOS:000336044200020 PM 24569533 ER PT J AU Harriff, MJ Cansler, ME Toren, KG Canfield, ET Kwak, S Gold, MC Lewinsohn, DM AF Harriff, Melanie J. Cansler, Meghan E. Toren, Katelynne Gardner Canfield, Elizabeth T. Kwak, Stephen Gold, Marielle C. Lewinsohn, David M. TI Human Lung Epithelial Cells Contain Mycobacterium tuberculosis in a Late Endosomal Vacuole and Are Efficiently Recognized by CD8(+) T Cells SO PLOS ONE LA English DT Article ID PHAGOSOME MATURATION; INTERFERON-GAMMA; ANTIGEN; INFECTION; PATHWAY; LYMPHOCYTES; ACTIVATION; FUSION; ARREST; IRON AB Mycobacterium tuberculosis (Mtb) is transmitted via inhalation of aerosolized particles. While alveolar macrophages are thought to play a central role in the acquisition and control of this infection, Mtb also has ample opportunity to interact with the airway epithelium. In this regard, we have recently shown that the upper airways are enriched with a population of non-classical, MR1-restricted, Mtb-reactive CD8(+) T cells (MAIT cells). Additionally, we have demonstrated that Mtb-infected epithelial cells lining the upper airways are capable of stimulating IFN gamma production by MAIT cells. In this study, we demonstrate that airway epithelial cells efficiently stimulate IFN gamma release by MAIT cells as well as HLA-B45 and HLA-E restricted T cell clones. Characterization of the intracellular localization of Mtb in epithelial cells indicates that the vacuole occupied by Mtb in epithelial cells is distinct from DC in that it acquires Rab7 molecules and does not retain markers of early endosomes such as Rab5. The Mtb vacuole is also heterogeneous as there is a varying degree of association with Lamp1 and HLA-I. Although the Mtb vacuole shares markers associated with the late endosome, it does not acidify, and the bacteria are able to replicate within the cell. This work demonstrates that Mtb infected lung epithelial cells are surprisingly efficient at stimulating IFN gamma release by CD8(+) T cells. C1 [Harriff, Melanie J.; Gold, Marielle C.; Lewinsohn, David M.] Portland VA Med Ctr, Portland, OR 97239 USA. [Harriff, Melanie J.; Canfield, Elizabeth T.; Kwak, Stephen; Gold, Marielle C.; Lewinsohn, David M.] Oregon Hlth & Sci Univ, Dept Pulm & Crit Care Med, Portland, OR 97201 USA. [Cansler, Meghan E.; Toren, Katelynne Gardner] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR 97201 USA. [Gold, Marielle C.; Lewinsohn, David M.] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA. RP Harriff, MJ (reprint author), Portland VA Med Ctr, Portland, OR 97239 USA. EM harriffm@ohsu.edu; lewinsod@ohsu.edu RI ; Lewinsohn, David/I-4936-2013 OI Gold, Marielle/0000-0003-2505-3291; Lewinsohn, David/0000-0001-9906-9494 FU Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development; Portland VA Medical Center; National Institutes of Health (NIH) [AI048090] FX Funding was provided by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, with resources and the use of facilities at the Portland VA Medical Center (Merit Review, DM Lewinsohn; Career Development Award, MJH), and the National Institutes of Health (NIH) grant, AI048090 (DM Lewinsohn). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 20 Z9 20 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 14 PY 2014 VL 9 IS 5 AR e97515 DI 10.1371/journal.pone.0097515 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI4TJ UT WOS:000336857400104 PM 24828674 ER PT J AU Komers, R Xu, B Fu, Y McClelland, A Kantharidis, P Mittal, A Cohen, HT Cohen, DM AF Komers, Radko Xu, Bei Fu, Yi McClelland, Aaron Kantharidis, Phillip Mittal, Amit Cohen, Herbert T. Cohen, David M. TI Transcriptome-Based Analysis of Kidney Gene Expression Changes Associated with Diabetes in OVE26 Mice, in the Presence and Absence of Losartan Treatment SO PLOS ONE LA English DT Article ID ENDOPLASMIC-RETICULUM-STRESS; THIOREDOXIN-INTERACTING PROTEIN; TISSUE GROWTH-FACTOR; ANGIOTENSIN-RECEPTOR BLOCKADE; LOW-DENSITY-LIPOPROTEIN; HIPPEL-LINDAU-DISEASE; ER STRESS; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE-STRESS AB Diabetes is among the most common causes of end-stage renal disease, although its pathophysiology is incompletely understood. We performed next-generation sequencing-based transcriptome analysis of renal gene expression changes in the OVE26 murine model of diabetes (age 15 weeks), relative to non-diabetic control, in the presence and absence of short-term (seven-day) treatment with the angiotensin receptor blocker, losartan (n = 3-6 biological replicates per condition). We detected 1438 statistically significant changes in gene expression across conditions. Of the 638 genes dysregulated in diabetes relative to the non-diabetic state, >70% were down-regulation events. Unbiased functional annotation of genes up-and down-regulated by diabetes strongly associated (p<1x10(-8)) with terms for oxidative stress and for endoplasmic reticulum stress/protein folding. Most of the individual gene products up-or down-regulated with diabetes were unaffected by losartan treatment; however, of the gene products dysregulated in diabetes and influenced by losartan treatment, the vast majority of changes were in the direction of amelioration rather than exacerbation of the diabetic dysregulation. This group of losartan-protected genes associated strongly with annotation terms for endoplasmic reticulum stress, heat shock proteins, and chaperone function, but not oxidative stress; therefore, the losartan-unaffected genes suggest avenues for additional therapeutic opportunity in diabetes. Interestingly, the gene product most highly upregulated by diabetes (>52-fold), encoded by the cationic amino acid transporter Slc7a12, and the gene product most highly downregulated by diabetes (>99%) - encoded by the "pseudogene" Gm6300 - are adjacent in the murine genome, are members of the SLC7 gene family, and are likely paralogous. Therefore, diabetes activates a near-total genetic switch between these two paralogs. Other individual-level changes in gene expression are potentially relevant to diabetic pathophysiology, and novel pathways are suggested. Genes unaffected by diabetes alone but exhibiting increased renal expression with losartan produced a signature consistent with malignant potential. C1 [Komers, Radko; Xu, Bei; Fu, Yi; Cohen, David M.] Oregon Hlth & Sci Univ, Dept Med, Div Nephrol & Hypertens, Portland, OR 97201 USA. [Komers, Radko; Xu, Bei; Fu, Yi; Cohen, David M.] Portland VA Med Ctr, Portland, OR USA. [Mittal, Amit; Cohen, Herbert T.] Boston Univ, Sch Med, Nephrol Sect, Boston, MA 02118 USA. [McClelland, Aaron; Kantharidis, Phillip] Baker IDI Heart & Diabet Inst, Diabet Div, JDRF Danielle Alberti Mem Ctr Diabet Complicat, Melbourne, Vic, Australia. RP Cohen, DM (reprint author), Oregon Hlth & Sci Univ, Dept Med, Div Nephrol & Hypertens, Portland, OR 97201 USA. EM cohend@ohsu.edu FU National Institutes of Health; Department of Veterans Affairs; American Diabetes Association FX This work was supported by grants from the National Institutes of Health, the Department of Veterans Affairs, and the American Diabetes Association (to DMC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 99 TC 0 Z9 0 U1 2 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 14 PY 2014 VL 9 IS 5 AR e96987 DI 10.1371/journal.pone.0096987 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI4TJ UT WOS:000336857400050 PM 24827579 ER PT J AU Graham, DY AF Graham, David Y. TI History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Helicobacter pylori; Duodenal ulcer; Gastric ulcer; Gastric cancer; Medical history; Ulcer surgery; Epidemiology; Gastritis; Atrophic gastritis; Antiquity ID PEPTIC-ULCER; CAMPYLOBACTER-PYLORI; HUMAN MIGRATIONS; STOMACH-CANCER; INFECTION; POPULATIONS; DISEASE; RISK; PATHOGENESIS; ERADICATION AB Helicobacter pylori (H. pylori) infection underlies gastric ulcer disease, gastric cancer and duodenal ulcer disease. The disease expression reflects the pattern and extent of gastritis/gastric atrophy (i.e., duodenal ulcer with non-atrophic and gastric ulcer and gastric cancer with atrophic gastritis). Gastric and duodenal ulcers and gastric cancer have been known for thousands of years. Ulcers are generally non-fatal and until the 20th century were difficult to diagnose. However, the presence and pattern of gastritis in past civilizations can be deduced based on the diseases present. It has been suggested that gastric ulcer and duodenal ulcer both arose or became more frequent in Europe in the 19th century. Here, we show that gastric cancer and gastric ulcer were present throughout the 17th to 19th centuries consistent with atrophic gastritis being the predominant pattern, as it proved to be when it could be examined directly in the late 19th century. The environment before the 20th century favored acquisition of H. pylori infection and atrophic gastritis (e.g., poor sanitation and standards of living, seasonal diets poor in fresh fruits and vegetables, especially in winter, vitamin deficiencies, and frequent febrile infections in childhood). The latter part of the 19th century saw improvements in standards of living, sanitation, and diets with a corresponding decrease in rate of development of atrophic gastritis allowing duodenal ulcers to become more prominent. In the early 20th century physician's believed they could diagnose ulcers clinically and that the diagnosis required hospitalization for "surgical disease" or for "Sippy" diets. We show that while H. pylori remained common and virulent in Europe and the United States, environmental changes resulted in changes of the pattern of gastritis producing a change in the manifestations of H. pylori infections and subsequently to a rapid decline in transmission and a rapid decline in all H. pylori-related diseases. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved. C1 Baylor Coll Med, VA Med Ctr, Houston, TX 77030 USA. RP Graham, DY (reprint author), Baylor Coll Med, VA Med Ctr, 2002 Holcombe Blvd,Rm 3A-318B 111D, Houston, TX 77030 USA. EM dgraham@bcm.edu FU Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service [DK062813, DK56338]; Texas Medical Center Digestive Diseases Center FX Supported by In part by the Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service grants No. DK062813 and No. DK56338 which funds the Texas Medical Center Digestive Diseases Center NR 90 TC 22 Z9 26 U1 3 U2 29 PU BAISHIDENG PUBLISHING GROUP INC PI PLEASANTON PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA SN 1007-9327 EI 2219-2840 J9 WORLD J GASTROENTERO JI World J. Gastroenterol. PD MAY 14 PY 2014 VL 20 IS 18 BP 5191 EP 5204 DI 10.3748/wjg.v20.i18.5191 PG 14 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AH3TJ UT WOS:000336048100003 PM 24833849 ER PT J AU Bradley, KA Kivlahan, DR AF Bradley, Katharine A. Kivlahan, Daniel R. TI Bringing Patient-Centered Care to Patients With Alcohol Use Disorders SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID SHARED DECISION-MAKING; HEALTH C1 [Bradley, Katharine A.] Grp Hlth Res Inst, Seattle, WA 98101 USA. [Bradley, Katharine A.] Ctr Excellence Subst Abuse Treatment & Educ, Seattle, WA USA. [Bradley, Katharine A.] Vet Affairs Puget Sound Hlth Care Syst, Hlth Serv Res & Dev, Seattle, WA USA. [Kivlahan, Daniel R.] Vet Hlth Adm, Washington, DC USA. [Bradley, Katharine A.] Univ Washington, Dept Med, Seattle, WA USA. [Bradley, Katharine A.] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Kivlahan, Daniel R.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. RP Bradley, KA (reprint author), Grp Hlth Res Inst, Metropolitan Pk E,1730 Minor Ave,Ste 1600, Seattle, WA 98101 USA. EM bradley.k@ghc.org FU NIAAA NIH HHS [R01 AA018702, R01AA018702] NR 16 TC 22 Z9 22 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 14 PY 2014 VL 311 IS 18 BP 1861 EP 1862 DI 10.1001/jama.2014.3629 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AH0GT UT WOS:000335798100017 PM 24825640 ER PT J AU Suri, P Boyko, EJ Goldberg, J Forsberg, CW Jarvik, JG AF Suri, Pradeep Boyko, Edward J. Goldberg, Jack Forsberg, Christopher W. Jarvik, Jeffrey G. TI Longitudinal associations between incident lumbar spine MRI findings and chronic low back pain or radicular symptoms: retrospective analysis of data from the longitudinal assessment of imaging and disability of the back (LAIDBACK) SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article DE Sciatica; Annular; Tear; Fissure; Herniation; Bulge; Impingement; Endplate; Modic; Stenosis; Extrusion; Spondylolisthesis; Facet; Arthritis; Zygapophyseal; Disc ID 7-YEAR FOLLOW-UP; RISK-FACTORS; ASYMPTOMATIC SUBJECTS; NATURAL-HISTORY; OSTEOARTHRITIS; PREVALENCE; COMORBIDITY; POPULATION; KNEE AB Background: There are few longitudinal cohort studies examining associations between incident MRI findings and incident spine-related symptom outcomes. Prior studies do not discriminate between the two distinct outcomes of low back pain (LBP) and radicular symptoms. To address this gap in the literature, we conducted a secondary analysis of existing data from the Longitudinal Assessment of Imaging and Disability of the Back (LAIDBACK). The purpose of this study was to examine the association of incident lumbar MRI findings with two specific spine-related symptom outcomes: 1) incident chronic bothersome LBP, and 2) incident radicular symptoms such as pain, weakness, or sensation alterations in the lower extremity. Methods: The original LAIDBACK study followed 123 participants without current LBP or sciatica, administering standardized MRI assessments of the lumbar spine at baseline and at 3-year follow-up, and collecting information on participant-reported spine-related symptoms and signs every 4 months for 3 years. These analyses examined bivariable and multivariable associations between incident MRI findings and symptom outcomes (LBP and radicular symptoms) using logistic regression. Results: Three-year cumulative incidence of new MRI findings ranged between 2 and 8%, depending on the finding. Incident annular fissures were associated with incident chronic LBP, after adjustment for prior back pain and depression (adjusted odds ratio [OR] 6.6; 95% confidence interval [CI] 1.2-36.9). All participants with incident disc extrusions (OR 5.4) and nerve root impingement (OR 4.1) reported incident radicular symptoms, although associations were not statistically significant. No other incident MRI findings showed large magnitude associations with symptoms. Conclusions: Even when applying more specific definitions for spine-related symptom outcomes, few MRI findings showed large magnitude associations with symptom outcomes. Although incident annular fissures, disc extrusions, and nerve root impingement were associated with incident symptom outcomes, the 3-year incidence of these MRI findings was extremely low, and did not explain the vast majority of incident symptom cases. C1 [Suri, Pradeep; Boyko, Edward J.; Goldberg, Jack; Forsberg, Christopher W.] VA Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA 98108 USA. [Suri, Pradeep] VA Puget Sound Hlth Care Syst, Div Rehabil Care Serv, Seattle, WA USA. [Suri, Pradeep] Univ Washington, Sch Med, Dept Rehabil Med, Seattle, WA 98195 USA. [Boyko, Edward J.] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA. [Goldberg, Jack] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Jarvik, Jeffrey G.] Univ Washington, Sch Med, Dept Radiol, Seattle, WA 98195 USA. [Jarvik, Jeffrey G.] Univ Washington, Sch Med, Dept Neurol Surg, Seattle, WA 98195 USA. [Jarvik, Jeffrey G.] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Seattle, WA 98195 USA. RP Suri, P (reprint author), VA Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA 98108 USA. EM pradeep.suriyaarachchi@va.gov OI Boyko, Edward/0000-0002-3695-192X FU Seattle VA Epidemiologic Research and Information Center (ERIC); VA Puget Sound; AHRQ [R01 HS019222-01]; NIH [1UH2AT007766-01] FX The LAIDBACK study was funded by the Seattle VA Epidemiologic Research and Information Center (ERIC). VA Puget Sound provided support for Dr. Suri's participation in this research. VA Puget Sound provided support for Dr. Goldberg's participation in this research. VA Puget Sound provided support for Mr. Forsberg's participation in this research. Dr. Jarvik was funded in part by AHRQ (R01 HS019222-01) and NIH (1UH2AT007766-01). VA Puget Sound provided support for Dr. Boyko's participation in this research. NR 34 TC 3 Z9 3 U1 4 U2 14 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD MAY 13 PY 2014 VL 15 AR 152 DI 10.1186/1471-2474-15-152 PG 10 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA AH2XV UT WOS:000335986300001 PM 24886265 ER PT J AU Luoto, J Shekelle, PG Maglione, MA Johnsen, B Perry, T AF Luoto, Jill Shekelle, Paul G. Maglione, Margaret A. Johnsen, Breanne Perry, Tanja TI Reporting of context and implementation in studies of global health interventions: a pilot study SO IMPLEMENTATION SCIENCE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; TO-CHILD TRANSMISSION; SAFE STORAGE; SOUTH-AFRICA; SERVICES; CARE; HIV; CHLORINATION; PREVENTION; MORTALITY AB Background: There is an increasing push for 'evidence-based' decision making in global health policy circles. However, at present there are no agreed upon standards or guidelines for how to evaluate evidence in global health. Recent evaluations of existing evidence frameworks that could serve such a purpose have identified details of program context and project implementation as missing components needed to inform policy. We performed a pilot study to assess the current state of reporting of context and implementation in studies of global health interventions. Methods: We identified three existing criteria sets for implementation reporting and selected from them 10 criteria potentially relevant to the needs of policy makers in global health contexts. We applied these 10 criteria to 15 articles included in the evidence base for three global health interventions chosen to represent a diverse set of advocated global health programs or interventions: household water chlorination, prevention of mother-to-child transmission of HIV, and lay community health workers to reduce child mortality. We used a good-fair-poor/none scale for the ratings. Results: The proportion of criteria for which reporting was poor/none ranged from 11% to 54% with an average of 30%. Eight articles had 'good' or 'fair' documentation for greater than 75% of criteria, while five articles had 'poor or none' documentation for 50% of criteria or more. Examples of good reporting were identified. Conclusions: Reporting of context and implementation information in studies of global health interventions is mostly fair or poor, and highly variable. The idiosyncratic variability in reporting indicates that global health investigators need more guidance about what aspects of context and implementation to measure and how to report them. This lack of context and implementation information is a major gap in the evidence needed by global health policy makers to reach decisions. C1 [Luoto, Jill; Shekelle, Paul G.; Maglione, Margaret A.; Johnsen, Breanne; Perry, Tanja] RAND Corp, Santa Monica, CA 90407 USA. [Shekelle, Paul G.] W Los Angeles Vet Affairs Med Ctr, Los Angeles, CA 90073 USA. RP Luoto, J (reprint author), RAND Corp, 1776 Main St, Santa Monica, CA 90407 USA. EM jluoto@rand.org FU PHS HHS [HHSA290200710062I] NR 30 TC 7 Z9 7 U1 3 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1748-5908 J9 IMPLEMENT SCI JI Implement. Sci. PD MAY 12 PY 2014 VL 9 AR 57 DI 10.1186/1748-5908-9-57 PG 9 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA AI3NW UT WOS:000336769400001 PM 24886201 ER PT J AU Prabhu, SD AF Prabhu, Sumanth D. TI It Takes Two to Tango Monocyte and Macrophage Duality in the Infarcted Heart SO CIRCULATION RESEARCH LA English DT Editorial Material DE Editorials; macrophages; monocytes; myocardial infarction; nuclear receptor subfamily 4; group A; member 1; ventricular remodeling ID ACUTE MYOCARDIAL-INFARCTION; SURVIVAL; PHENOTYPE; INJURY; REPAIR; CELLS; MICE C1 Univ Alabama Birmingham, Div Cardiovasc Dis, Dept Med, Birmingham, AL 35294 USA. Birmingham VA Med Ctr, Med Serv, Birmingham, AL USA. RP Prabhu, SD (reprint author), Univ Alabama Birmingham, Div Cardiovasc Dis, 311 Tinsley Harrison Tower,1900 Univ Blvd, Birmingham, AL 35294 USA. EM sprabhu@uab.edu FU NHLBI NIH HHS [HL-78825, P01 HL078825, R01 HL099014, HL-99014] NR 22 TC 4 Z9 4 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7330 EI 1524-4571 J9 CIRC RES JI Circ.Res. PD MAY 9 PY 2014 VL 114 IS 10 BP 1558 EP 1560 DI 10.1161/CIRCRESAHA.114.303933 PG 3 WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Hematology GA AH2HF UT WOS:000335941400015 PM 24812348 ER PT J AU Novgorodov, SA Riley, CL Yu, J Borg, KT Hannun, YA Proia, RL Kindy, MS Gudz, TI AF Novgorodov, Sergei A. Riley, Christopher L. Yu, Jin Borg, Keith T. Hannun, Yusuf A. Proia, Richard L. Kindy, Mark S. Gudz, Tatyana I. TI Essential Roles of Neutral Ceramidase and Sphingosine in Mitochondrial Dysfunction Due to Traumatic Brain Injury SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article DE Brain; Cell Death; Mitochondria; Respiratory Chain; Sphingolipid ID CYTOCHROME-C-OXIDASE; SUBCELLULAR-LOCALIZATION; CHRONIC ACTIVATION; RESPIRATORY-CHAIN; MOLECULAR-CLONING; RAT-BRAIN; IN-VITRO; KINASE; SPHINGOSINE-1-PHOSPHATE; SPHINGOLIPIDS AB Background: A cardinal feature of many neurological disorders is mitochondrial dysfunction. Results: Knocking down neutral ceramidase reduces mitochondrial sphingosine, preserves mitochondrial function, and improves brain function recovery after trauma. Conclusion: Activation of the sphingosine-generating pathway plays a significant role in promoting mitochondrial injury. Significance: This is the first direct evidence of endogenous sphingosine involvement in regulation of mitochondrial function. In addition to immediate brain damage, traumatic brain injury (TBI) initiates a cascade of pathophysiological events producing secondary injury. The biochemical and cellular mechanisms that comprise secondary injury are not entirely understood. Herein, we report a substantial deregulation of cerebral sphingolipid metabolism in a mouse model of TBI. Sphingolipid profile analysis demonstrated increases in sphingomyelin species and sphingosine concurrently with up-regulation of intermediates of de novo sphingolipid biosynthesis in the brain. Investigation of intracellular sites of sphingosine accumulation revealed an elevation of sphingosine in mitochondria due to the activation of neutral ceramidase (NCDase) and the reduced activity of sphingosine kinase 2 (SphK2). The lack of change in gene expression suggested that post-translational mechanisms are responsible for the shift in the activities of both enzymes. Immunoprecipitation studies revealed that SphK2 is complexed with NCDase and cytochrome oxidase (COX) subunit 1 in mitochondria and that brain injury hindered SphK2 association with the complex. Functional studies showed that sphingosine accumulation resulted in a decreased activity of COX, a rate-limiting enzyme of the mitochondrial electron transport chain. Knocking down NCDase reduced sphingosine accumulation in mitochondria and preserved COX activity after the brain injury. Also, NCDase knockdown improved brain function recovery and lessened brain contusion volume after trauma. These studies highlight a novel mechanism of secondary TBI involving a disturbance of sphingolipid-metabolizing enzymes in mitochondria and suggest a critical role for mitochondrial sphingosine in promoting brain injury after trauma. C1 [Riley, Christopher L.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29401 USA. [Yu, Jin; Kindy, Mark S.; Gudz, Tatyana I.] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA. [Novgorodov, Sergei A.; Kindy, Mark S.; Gudz, Tatyana I.] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA. [Borg, Keith T.] Med Univ S Carolina, Dept Emergency Med, Charleston, SC 29425 USA. [Hannun, Yusuf A.] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA. [Proia, Richard L.] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA. RP Gudz, TI (reprint author), 114 Doughty St, Charleston, SC 29425 USA. EM gudz@musc.edu FU National Institutes of Health [P30 GM103339]; Veterans Affairs Merit Awards [I01RX000206, I01BX001104, I01RX000331]; American Diabetes Association [7-12-IN-28] FX This work was supported, in whole or in part, by National Institutes of Health Grant P30 GM103339 (to S. A. N.). This work was also supported by Veterans Affairs Merit Awards I01RX000206 (to T. I. G.), I01BX001104 (to T. I. G.), and I01RX000331 (to M. S. K.). The Lipidomics Core Facility at Medical University of South Carolina is supported in part by National Institutes of Health Grant P30 GM103339.; Supported in part by American Diabetes Association Innovation Grant 7-12-IN-28. NR 64 TC 10 Z9 11 U1 0 U2 7 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD MAY 9 PY 2014 VL 289 IS 19 BP 13142 EP 13154 DI 10.1074/jbc.M113.530311 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AG6IR UT WOS:000335522800016 PM 24659784 ER PT J AU Asch, DA Terwiesch, C Mahoney, KB Rosin, R AF Asch, David A. Terwiesch, Christian Mahoney, Kevin B. Rosin, Roy TI Insourcing Health Care Innovation SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material AB Rather than seek solutions to health care's problems in facile recommendations from management gurus with experience in unrelated industries, we'd do better to find a solution process to use from within. And the process for high-impact innovation can in fact be learned. Many health care professionals find it irritating when management gurus recommend solving health care's problems with approaches they would copy and paste from unrelated industries a former chief executive of a manufacturing company claims that the same simple lessons that enabled him to transform his own industry can improve value in health care, or a business-school professor offers an eight-point leadership plan that she's translated into health care as easily as if she'd translated it into French. Many people who work in health care value outside perspectives and are open to new approaches and yet bristle at facile ... C1 [Asch, David A.] Univ Penn, Ctr Hlth Equ Res & Promot, Philadelphia Vet Affairs Med Ctr, Philadelphia, PA 19104 USA. [Asch, David A.; Terwiesch, Christian; Mahoney, Kevin B.; Rosin, Roy] Univ Penn, Ctr Hlth Care Innovat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Terwiesch, Christian] Univ Penn, Mack Inst Innovat Management, Wharton Sch, Philadelphia, PA 19104 USA. RP Asch, DA (reprint author), Univ Penn, Ctr Hlth Equ Res & Promot, Philadelphia Vet Affairs Med Ctr, Philadelphia, PA 19104 USA. NR 1 TC 3 Z9 3 U1 0 U2 6 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAY 8 PY 2014 VL 370 IS 19 BP 1775 EP 1777 DI 10.1056/NEJMp1401135 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AH3CD UT WOS:000335997900003 PM 24806157 ER PT J AU Yu, MK Weiss, NS Ding, XB Katon, WJ Zhou, XH Young, BA AF Yu, Margaret K. Weiss, Noel S. Ding, Xiaobo Katon, Wayne J. Zhou, Xiao-Hua Young, Bessie A. TI Associations between Depressive Symptoms and Incident ESRD in a Diabetic Cohort SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID CHRONIC KIDNEY-DISEASE; PROPORTIONAL HAZARDS MODEL; MAJOR DEPRESSION; SELF-CARE; COMORBID DEPRESSION; MEDICATION ADHERENCE; RISK-FACTORS; FOLLOW-UP; ALL-CAUSE; MORTALITY AB Background and objectivesComorbid major depression is associated with adverse health outcomes in patients with diabetes, but little is known regarding its associations with long-term renal outcomes in this population. Furthermore, the impact of minor depression on renal outcomes is not known. This study evaluated associations between depressive symptoms and risk of incident ESRD in a diabetic cohort.Design, setting, participants, & measurementsIn this prospective, observational cohort study, 3886 ambulatory adults with diabetes were recruited from primary care clinics of a large health maintenance organization in the state of Washington. Demographics, laboratory data, depressive symptoms (based on the Patient Health Questionnaire-9), and patterns of diabetes self-care were collected. Participants were considered depressed if they had the required number of depressive symptoms (5 for major or 2-4 for minor depressive symptoms), including depressed mood or anhedonia, >50% of the time for 2 weeks and a Patient Health Questionnaire-9 score10 for major and 5 for minor depressive symptoms. Risk of incident ESRD was estimated using Cox proportional hazards regression, with predialysis death as a competing risk.ResultsDuring a median follow-up of 8.8 years, 87 patients (2.2%) developed ESRD. Major depressive symptoms were associated with a higher risk of incident ESRD (hazard ratio, 1.85; 95% confidence interval, 1.02 to 3.33) after adjusting for age, sex, race/ethnicity, marital status, education, smoking, body mass index, diabetes duration, hemoglobin A1c, baseline kidney function, microalbuminuria, hypertension, renin-angiotensin system blockers, and adherence to diabetes self-care. Minor depressive symptoms were not significantly associated with incident ESRD (hazard ratio, 1.08; 95% confidence interval, 0.52 to 2.25).ConclusionMajor depressive symptoms, but not minor depressive symptoms, were associated with a higher risk of incident ESRD over 10 years. Additional studies are needed to determine whether treatment for depression can improve renal outcomes in patients with diabetes. C1 [Yu, Margaret K.; Young, Bessie A.] Vet Affairs Puget Sound Hlth Care Syst, Hlth Serv Res & Dev, Seattle, WA USA. [Zhou, Xiao-Hua; Young, Bessie A.] Vet Affairs Puget Sound Hlth Care Syst, Epidemiol Res & Informat Ctr, Seattle, WA USA. [Yu, Margaret K.; Young, Bessie A.] Univ Washington, Sch Med, Dept Med, Div Nephrol, Seattle, WA 98195 USA. [Yu, Margaret K.; Young, Bessie A.] Univ Washington, Sch Med, Kidney Res Inst, Seattle, WA USA. [Katon, Wayne J.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Yu, Margaret K.; Weiss, Noel S.; Young, Bessie A.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Ding, Xiaobo; Zhou, Xiao-Hua] Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA. [Young, Bessie A.] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Seattle, WA 98195 USA. [Ding, Xiaobo] Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China. RP Young, BA (reprint author), Vet Affairs Puget Sound Hlth Care Syst 152E, Epidemiol Res & Informat Ctr, 1660 S Columbian Way, Seattle, WA 98108 USA. EM youngb@u.washington.edu FU National Institute of Mental Health Services [MH41739, MH01643]; American Kidney Fund; Veterans Affairs Puget Sound Health Care System FX We thank Dr. Michael Von Korff, Dr. Elizabeth Lin, Dr. Evette Ludman, and Malia Oliver for their roles in study design, data acquisition, and obtainment of funding for the Pathways Study, which was supported by National Institute of Mental Health Services Grants MH41739 and MH01643.; M.K.Y. was supported, in part, by the American Kidney Fund. In addition, this material is the result of work supported by resources from the Veterans Affairs Puget Sound Health Care System(M.K.Y. and B.A.Y.). NR 48 TC 10 Z9 10 U1 2 U2 7 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 EI 1555-905X J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD MAY 7 PY 2014 VL 9 IS 5 BP 920 EP 928 DI 10.2215/CJN.08670813 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA AG6HI UT WOS:000335519300015 PM 24677559 ER PT J AU Aljebreen, AM Almadi, MA Leung, FW AF Aljebreen, Abdulrahman M. Almadi, Majid A. Leung, Felix W. TI Sedated vs unsedated colonoscopy: A prospective study SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Sedation; Colonoscopy; Unsedated; Screening; Endoscopy ID RANDOMIZED CONTROLLED-TRIAL; SCREENING COLONOSCOPY; SELECTIVE SEDATION; VETERANS; OPTIONS; ROUTINE AB AIM: To compare sedated to unsedated colonoscopy in terms of duration, pain and the patient's willingness to repeat the procedure. METHODS: Consecutive patients who underwent colonoscopies over a 2-year period were invited to participate. All patients who were to undergo our endoscopy unit were offered sedation with standard intravenous sedatives and analgesics, or an unsedated colonoscopy was attempted. Demographic details were recorded. The patient anxiety level prior to the procedure, time to reach the cecum, total discharge time, patient and endoscopist pain assessments, satisfaction after the examination and the patient's willingness to return for the same procedure in the future were recorded. RESULTS: Among the 403 observed patients, more males were observed in the unsedated group (66.2% vs 55.2%, P = 0.04). Additionally, the unsedated group patients were less anxious prior to the procedure (5.1 vs 6.0, P < 0.01). The colonoscopy completion rates were comparable between the 2 groups (85.9% vs 84.2%, P = 0.66). The time to reach the cecum was also comparable (12.2 min vs 11.8 min); however, the total discharge times were shorter in the unsedated group (20.7 min vs 83.0 min, P < 0.01). Moreover, the average patient pain score (3.4 vs 5.7, P < 0.01) was lower in the sedated group, while the satisfaction score (8.8 vs 7.8, P < 0.01) was significantly higher. There was no significant difference, however, between the groups in terms of willingness to repeat the procedure if another was required in the future (83.3% vs 77.3%, P = 0.17). CONCLUSION: Unsedated colonoscopy is feasible in willing patients. The option saves the endoscopy units up to one hour per patient and does not affect the patient willingness to return to the same physician again for additional colonoscopies if a repeated procedure is needed. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved. C1 [Aljebreen, Abdulrahman M.; Almadi, Majid A.] King Saud Univ, King Khalid Univ Hosp, Div Gastroenterol, Riyadh 11461, Saudi Arabia. [Almadi, Majid A.] McGill Univ, Ctr Hlth, Div Gastroenterol, Montreal, PQ H3G 1A4, Canada. [Leung, Felix W.] Vet Affairs Greater Los Angeles Healthcare Syst, Sepulveda Ambulatory Care Ctr, Res Serv, Los Angeles, CA 91343 USA. [Leung, Felix W.] Vet Affairs Greater Los Angeles Healthcare Syst, Sepulveda Ambulatory Care Ctr, Med Serv, Los Angeles, CA 91343 USA. [Leung, Felix W.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 91343 USA. RP Aljebreen, AM (reprint author), King Saud Univ, King Khalid Univ Hosp, Div Gastroenterol, POB 2925, Riyadh 11461, Saudi Arabia. EM amaljebreen@gmail.com FU College of Medicine Research Center, Deanship of Scientific Research, King Saud University FX Supported by Partially by College of Medicine Research Center, Deanship of Scientific Research, King Saud University NR 23 TC 4 Z9 4 U1 0 U2 2 PU BAISHIDENG PUBLISHING GROUP INC PI PLEASANTON PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA SN 1007-9327 EI 2219-2840 J9 WORLD J GASTROENTERO JI World J. Gastroenterol. PD MAY 7 PY 2014 VL 20 IS 17 BP 5113 EP 5118 DI 10.3748/wjg.v20.i17.5113 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AH1YC UT WOS:000335916700035 PM 24803827 ER PT J AU Mudumbai, SC Wagner, T Mahajan, S King, R Heidenreich, PA Hlatky, M Wallace, AW Mariano, ER AF Mudumbai, Seshadri C. Wagner, Todd Mahajan, Satish King, Robert Heidenreich, Paul A. Hlatky, Mark Wallace, Arthur W. Mariano, Edward R. TI Effectiveness of preoperative beta-blockade on intra-operative heart rate in vascular surgery cases conducted under regional or local anesthesia SO SPRINGERPLUS LA English DT Article DE Perioperative medicine; Vascular surgery; beta-blockers; Heart rate; General anesthesia; Regional anesthesia; Monitored anesthesia care; Effectiveness ID GENERAL-ANESTHESIA; EPIDURAL-ANESTHESIA; ANALGESIA; BLOCKERS; EFFICACY; TRIALS; CARE AB Background: Preoperative beta-blockade has been posited to result in better outcomes for vascular surgery patients by attenuating acute hemodynamic changes associated with stress. However, the incremental effectiveness, if any, of beta-blocker usage in blunting heart rate responsiveness for vascular surgery patients who avoid general anesthesia remains unknown. Methods: We reviewed an existing database and identified 213 consecutive vascular surgery cases from 2005-2011 conducted without general anesthesia (i.e., under monitored anesthesia care or regional anesthesia) at a tertiary care Veterans Administration medical center and categorized patients based on presence or absence of preoperative beta-blocker prescription. For this series of patients, with the primary outcome of maximum heart rate during the interval between operating room entry to surgical incision, we examined the association of maximal heart rate and preoperative beta-blocker usage by performing crude and multivariate linear regression, adjusting for relevant patient factors. Results: Of 213 eligible cases, 137 were prescribed preoperative beta-blockers, and 76 were not. The two groups were comparable across baseline patient factors and intraoperative medication doses. The beta-blocker group experienced lower maximal heart rates during the period of evaluation compared to the non-beta-blocker group (85 +/- 22 bpm vs. 98 +/- 36 bpm, respectively; p = 0.002). Adjusted linear regression confirmed a statistically-significant association between lower maximal heart rate and the use of beta-blockers (Beta = -11.5; 95% CI [-3.7, -19.3] p = 0.004). Conclusions: The addition of preoperative beta-blockers, even when general anesthesia is avoided, may be beneficial in further attenuating stress-induced hemodynamic changes for vascular surgery patients. C1 [Mudumbai, Seshadri C.; King, Robert; Mariano, Edward R.] Vet Affairs Palo Alto Hlth Care Syst, Anesthesiol & Perioperat Care Serv, Palo Alto, CA 94304 USA. [Mudumbai, Seshadri C.; Mariano, Edward R.] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA. [Wagner, Todd] Vet Affairs Palo Alto Hlth Care Syst, Ctr Innovat Implementat, Palo Alto, CA 94304 USA. [Mahajan, Satish] Vet Affairs Palo Alto Hlth Care Syst, Dept Nursing, Palo Alto, CA 94304 USA. [Heidenreich, Paul A.] Vet Affairs Palo Alto Hlth Care Syst, Serv Cardiol, Palo Alto, CA 94304 USA. [Heidenreich, Paul A.] Stanford Univ, Sch Med, Dept Cardiol, Stanford, CA 94305 USA. [Hlatky, Mark] Dept Hlth Res & Policy, Stanford, CA USA. [Hlatky, Mark] Dept Med Cardiovasc Med, Stanford, CA USA. [Wallace, Arthur W.] San Francisco VA Med Ctr, Anesthesia Serv, San Francisco, CA USA. [Wallace, Arthur W.] Univ Calif San Francisco, Dept Anesthesiol & Perioperat Care, San Francisco, CA 94143 USA. RP Mudumbai, SC (reprint author), Vet Affairs Palo Alto Hlth Care Syst, Anesthesiol & Perioperat Care Serv, 3801 Miranda Ave, Palo Alto, CA 94304 USA. EM mudumbai@stanford.edu OI Heidenreich, Paul/0000-0001-7730-8490; Mariano, Edward/0000-0003-2735-248X NR 22 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 2193-1801 J9 SPRINGERPLUS JI SpringerPlus PD MAY 5 PY 2014 VL 3 AR 227 DI 10.1186/2193-1801-3-227 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CO3EI UT WOS:000359039000002 PM 24855591 ER PT J AU Chiyomaru, T Fukuhara, S Saini, S Majid, S Deng, GR Shahryari, V Chang, I Tanaka, Y Enokida, H Nakagawa, M Dahiya, R Yamamura, S AF Chiyomaru, Takeshi Fukuhara, Shinichiro Saini, Sharanjot Majid, Shahana Deng, Guoren Shahryari, Varahram Chang, Inik Tanaka, Yuichiro Enokida, Hideki Nakagawa, Masayuki Dahiya, Rajvir Yamamura, Soichiro TI Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article DE Cancer Biology; Cell Growth; Gene Regulation; Invasion; MicroRNA; Genistein; HOTAIR; Long Non-coding RNA; miR-141; Renal Carcinoma ID EPITHELIAL-MESENCHYMAL TRANSITION; MAMMALIAN MESSENGER-RNAS; TRANSCRIPTIONAL ACTIVITY; MICRORNA TARGETS; MIR-200 FAMILY; CODING REGIONS; PROSTATE-CANCER; GENE-EXPRESSION; REPRESSORS ZEB1; ALPHA-AMANITIN AB Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its oncogenic function in Ago2 (Argounaute2). Conclusion: miR-141 targets and silences HOTAIR in an Ago2-dependent manner in cancer cells. Significance: Our results suggest that regulation of lncRNA expression by miRNA plays essential roles in gene expression and cellular functions. HOTAIR is a long non-coding RNA that interacts with the polycomb repressive complex and suppresses its target genes. HOTAIR has also been demonstrated to promote malignancy. MicroRNA-141 (miR-141) has been reported to play a role in the epithelial to mesenchymal transition process, and the expression of miR-141 is inversely correlated with tumorigenicity and invasiveness in several human cancers. We found that HOTAIR expression is inversely correlated to miR-141 expression in renal carcinoma cells. HOTAIR promotes malignancy, including proliferation and invasion, whereas miR-141 suppresses malignancy in human cancer cells. miR-141 binds to HOTAIR in a sequence-specific manner and suppresses HOTAIR expression and functions, including proliferation and invasion. Both HOTAIR and miR-141 were associated with the immunoprecipitated Ago2 (Argonaute2) complex, and the Ago2 complex cleaved HOTAIR in the presence of miR-141. These results demonstrate that HOTAIR is suppressed by miR-141 in an Ago2-dependent manner. C1 [Chiyomaru, Takeshi; Fukuhara, Shinichiro; Saini, Sharanjot; Majid, Shahana; Deng, Guoren; Shahryari, Varahram; Tanaka, Yuichiro; Dahiya, Rajvir; Yamamura, Soichiro] San Francisco VA Med Ctr, Dept Urol, San Francisco, CA 94121 USA. [Chiyomaru, Takeshi; Fukuhara, Shinichiro; Saini, Sharanjot; Majid, Shahana; Deng, Guoren; Shahryari, Varahram; Tanaka, Yuichiro; Dahiya, Rajvir; Yamamura, Soichiro] Univ Calif San Francisco, San Francisco, CA 94121 USA. [Chang, Inik] Yonsei Univ, Coll Dent, Dept Oral Biol, Seoul 120752, South Korea. [Enokida, Hideki; Nakagawa, Masayuki] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Urol, Kagoshima 8908520, Japan. RP Yamamura, S (reprint author), Vet Affairs Med Ctr, Urol Res Ctr 112F, 4150 Clement St, San Francisco, CA 94121 USA. EM yamamuras@urology.ucsf.edu FU National Institutes of Health [RO1CA130860]; Veterans Affairs Program Project; Veterans Affairs Merit Review grants FX This work was supported, in whole or in part, by National Institutes of Health Grant RO1CA130860. This study was also supported by Veterans Affairs Program Project and Veterans Affairs Merit Review grants. NR 61 TC 54 Z9 60 U1 3 U2 31 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD MAY 2 PY 2014 VL 289 IS 18 BP 12550 EP 12565 DI 10.1074/jbc.M113.488593 PG 16 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AG7ER UT WOS:000335581400029 PM 24616104 ER PT J AU Kamnaksh, A Budde, MD Kovesdi, E Long, JB Frank, JA Agoston, DV AF Kamnaksh, Alaa Budde, Matthew D. Kovesdi, Erzsebet Long, Joseph B. Frank, Joseph A. Agoston, Denes V. TI Diffusion Tensor Imaging Reveals Acute Subcortical Changes after Mild Blast-Induced Traumatic Brain Injury SO SCIENTIFIC REPORTS LA English DT Article ID LONG-TERM CONSEQUENCES; AXONAL INJURY; MILITARY; CONCUSSION; BIOMARKERS; VETERANS; COMBAT; MODEL; RATS; MRI AB Mild blast-induced traumatic brain injury (mbTBI) poses special diagnostic challenges due to its overlapping symptomatology with other neuropsychiatric conditions and the lack of objective outcome measures. Diffusion tensor imaging (DTI) can potentially provide clinically relevant information toward a differential diagnosis. In this study, we aimed to determine if single and repeated (5 total; administered on consecutive days) mild blast overpressure exposure results in detectable structural changes in the brain, especially in the hippocampus. Fixed rat brains were analyzed by ex vivo DTI at 2 h and 42 days after blast (or sham) exposure(s). An anatomy-based region of interest analysis revealed significant interactions in axial and radial diffusivity in a number of subcortical structures at 2 h only. Differences between single-and multiple-injured rats were largely in the thalamus but not the hippocampus. Our findings demonstrate the value and the limitations of DTI in providing a better understanding of mbTBI pathobiology. C1 [Kamnaksh, Alaa; Agoston, Denes V.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Kamnaksh, Alaa] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. [Budde, Matthew D.; Frank, Joseph A.] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD 20892 USA. [Kovesdi, Erzsebet] US Dept Vet Affairs, Vet Affairs Cent Off, Washington, DC 20420 USA. [Long, Joseph B.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Agoston, DV (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM denes.agoston@usuhs.edu FU Center for Neuroscience and Regenerative Medicine [G1703F] FX We thank the Neurotrauma Team at the Walter Reed Army Institute of Research for their technical help during the exposures, along with Eric Gold and Lindsay Janes for assistance with the MRI experiments. This work was supported by the Center for Neuroscience and Regenerative Medicine grant number G1703F. NR 59 TC 7 Z9 8 U1 2 U2 12 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD MAY 2 PY 2014 VL 4 AR 4809 DI 10.1038/srep04809 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AG1ZZ UT WOS:000335216000001 PM 24786839 ER PT J AU Wisneski, AD Matthews, PB Azadani, AN Mookhoek, A Chitsaz, S Guccione, JM Ge, L Tseng, EE AF Wisneski, Andrew D. Matthews, Peter B. Azadani, Ali N. Mookhoek, Aart Chitsaz, Sam Guccione, Julius M. Ge, Liang Tseng, Elaine E. TI Human Pulmonary Autograft Wall Stress at Systemic Pressures Prior to Remodeling After the Ross Procedure SO JOURNAL OF HEART VALVE DISEASE LA English DT Article ID AORTIC-VALVE DISEASE; FINITE-ELEMENT; ROOT; DEGENERATION; REPLACEMENT; ANEURYSM AB Background and aim of the study: Remodeling of the pulmonary autograft upon exposure to systemic pressure can lead to progressive dilatation and aneurysmal pathology. Remodeling is driven by changes in autograft wall stress upon exposure to systemic pressure; however, the magnitude of these changes is unknown. Previously, a porcine autograft finite element model was developed to determine wall stress, but the porcine and human material properties differed significantly. Hence, the study aim was to understand human pulmonary autograft biomechanics that lead to remodeling by determining wall stress magnitudes immediately after the Ross procedure using finite element analysis (FEA). Methods: Human pulmonary root was scanned by high-resolution microcomputed tomography to construct a realistic three-dimensional geometric mesh. Stress-strain data from biaxial stretch testing was incorporated into an Ogden hyperelastic model to describe autograft mechanical properties for an adult Ross patient. Autograft dilatation and wall stress distribution during pulmonic and systemic pressures prior to remodeling were determined using explicit FEA in LS-DYNA. Results: Human pulmonary autograft demonstrated non-linear material properties, being highly compliant in the low-strain region, and stiffening at high strain. The majority of dilatation occurred with <20 mmHg pressurization. From pulmonary to systemic pressures, the increases in autograft diameter were up to 17%. Likewise, the maximal wall stress increased approximately 14.6-fold compared to diastolic pressures (from 13.0 to 190.1kPa), and six-fold compared to systolic pressures (from 48.6 to 289.6kPa). Conclusion: The first finite element model of the human pulmonary autograft was developed and used to demonstrate how autograft material properties prevent significant dilatation upon initial exposure to systemic pressure. Mild dilatation was noted in the sinuses and sinotubular junction. Autograft wall stress was increased greatly when subjected to systemic pressures, and may trigger biomechanical remodeling of the autograft. Sustained exposure to higher wall stresses, coupled with inadequate remodeling, may lead to future autograft dilatation. C1 [Wisneski, Andrew D.; Matthews, Peter B.; Azadani, Ali N.; Chitsaz, Sam; Guccione, Julius M.; Ge, Liang; Tseng, Elaine E.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA. [Wisneski, Andrew D.; Matthews, Peter B.; Azadani, Ali N.; Chitsaz, Sam; Guccione, Julius M.; Ge, Liang; Tseng, Elaine E.] San Francisco VA Med Ctr, San Francisco, CA USA. [Mookhoek, Aart] Erasmus MC, Dept Surg, Rotterdam, Netherlands. RP Tseng, EE (reprint author), UCSF Med Ctr, Div Cardiothorac Surg, 500 Parnassus Ave,Suite 405W,Box 0118, San Francisco, CA 94143 USA. EM elaine.tseng@ucsfmedctr.org FU American Heart Association FX This study was funded by American Heart Association Grant-in-Aid, administered by the Northern California Institute for Research and Education, using the resources of the San Francisco Veterans Affairs Medical Center. The authors also thank the California Organ Transplant Donor Network for heart specimens. NR 26 TC 1 Z9 1 U1 0 U2 1 PU I C R PUBLISHERS PI NORTHWOOD PA CRISPIN HOUSE, 12/A SOUTH APPROACH, MOOR PARK, NORTHWOOD HA6 2ET, ENGLAND SN 0966-8519 J9 J HEART VALVE DIS JI J. Heart Valve Dis. PD MAY PY 2014 VL 23 IS 3 BP 377 EP 384 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CB4BJ UT WOS:000349572900019 PM 25296465 ER PT J AU Winans-Mitrik, RL Hula, WD Dickey, MW Schumacher, JG Swoyer, B Doyle, PJ AF Winans-Mitrik, Ronda L. Hula, William D. Dickey, Michael W. Schumacher, James G. Swoyer, Brooke Doyle, Patrick J. TI Description of an Intensive Residential Aphasia Treatment Program: Rationale, Clinical Processes, and Outcomes SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY LA English DT Article DE aphasia; outcomes; response to intervention; stroke; effectiveness ID HEALTH-CARE UTILIZATION; RURAL REGION; THERAPY; ADULTS; REHABILITATION; EFFICACY; ACCESS; FORMS; MODEL AB Purpose: The purpose of this article is to describe the rationale, clinical processes, and outcomes of an intensive comprehensive aphasia program (ICAP). Method: Seventy-three community-dwelling adults with aphasia completed a residentially based ICAP. Participants received 5 hr of daily 1:1 evidence-based cognitivelinguistically oriented aphasia therapy, supplemented with weekly socially oriented and therapeutic group activities over a 23-day treatment course. Standardized measures of aphasia severity and communicative functioning were obtained at baseline, program entry, program exit, and follow-up. Results were analyzed using a Bayesian latent growth curve model with 2 factors representing (a) the initial level and (b) change over time, respectively, for each outcome measure. Results: Model parameter estimates showed reliable improvement on all outcome measures between the initial and final assessments. Improvement during the treatment interval was greater than change observed across the baseline interval, and gains were maintained at follow-up on all measures. Conclusions: The rationale, clinical processes, and outcomes of a residentially based ICAP have been described. ICAPs differ with respect to treatments delivered, dosing parameters, and outcomes measured. Specifying the defining components of complex interventions, establishing their feasibility, and describing their outcomes are necessary to guide the development of controlled clinical trials. C1 [Winans-Mitrik, Ronda L.; Hula, William D.; Dickey, Michael W.; Schumacher, James G.; Swoyer, Brooke; Doyle, Patrick J.] VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15261 USA. [Hula, William D.; Dickey, Michael W.; Doyle, Patrick J.] Univ Pittsburgh, Pittsburgh, PA 15260 USA. RP Doyle, PJ (reprint author), VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15261 USA. EM patrick.doyle@va.gov NR 57 TC 7 Z9 7 U1 7 U2 18 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1058-0360 EI 1558-9110 J9 AM J SPEECH-LANG PAT JI Am. J. Speech-Lang. Pathol. PD MAY PY 2014 VL 23 IS 2 BP 330 EP 342 DI 10.1044/2014_AJSLP-13-0102 PG 13 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA AU5ZP UT WOS:000345682200019 PM 24687159 ER PT J AU Post, JB Morin, KG Handrakis, JP Rivera, DR Yen, C Sano, M Spungen, AM AF Post, James B. Morin, Kel G. Handrakis, John P. Rivera, Dwindally Rosado Yen, Christina Sano, Mary Spungen, Ann M. TI Cognition may be related to arterial pulsatility index in HD patients SO CLINICAL NEPHROLOGY LA English DT Article DE pulsatility; cognitive impairment; hemodialysis ID HEMODIALYSIS-PATIENTS; RENAL-DISEASE; CAROTID-ARTERY; IMPAIRMENT; HYPERPARATHYROIDISM; MICROANGIOPATHY AB Aims: Hemodialysis (HD) patients have a heavy burden of subclinical cerebrovascular disease and cognitive changes consistent with a vascular etiology. Pulsatility index is associated with microangiopathy of cerebral blood vessels and an increased risk of cerebral infarction. The proposed study was to determine common carotid artery pulsatility index (CCAPI) and its relation to cognition in well-dialyzed HD patients with no history of stroke or dementia and matched controls. Methods: Observational, cross-sectional study of CCAPI and cognition in 37 hemodialysis outpatients and 18 matched controls with normal kidney function. Non-parametric analyses were used to compare variables between groups. Multiple regression and ANOVA models were used to adjust for risk factor differences. Results: Controls had a lower CCAPI than the HD group (1.7 +/- 0.3 vs. 2.1 +/- 0.4 cm/s, p = 0.006). HD patients scored significantly lower on all cognitive domains. Attention correlated with CCAPI in HD patients, independent of hypertension, diabetes, hyperlipidemia, and years on HD (r(2) = -0.36, p = 0.01). CCAPI correlated with years on HD, independent of traditional cardiovascular risk factors. (r(2) = 0.26, p = 0.04). Conclusion: In well-dialyzed hemodialysis patients with no history of stroke or dementia, -CCAPI may correlate with cognitive function and represent a marker for underlying cerebral microvascular disease. C1 [Post, James B.] James J Peters VA Med Ctr, Div Nephrol, Bronx, NY 10468 USA. [Post, James B.; Morin, Kel G.; Handrakis, John P.; Rivera, Dwindally Rosado; Yen, Christina; Spungen, Ann M.] James J Peters VA Med Ctr, VA RR&D Ctr Excellence Med Consequences SCI, Bronx, NY 10468 USA. [Handrakis, John P.] New York Inst Technol, Sch Hlth Professionals, Dept Phys Therapy, Old Westbury, NY 11568 USA. [Sano, Mary] James J Peters VA Med Ctr, VA RR&D, Bronx, NY 10468 USA. [Post, James B.] Mt Sinai Sch Med, Dept Med, New York, NY USA. [Sano, Mary] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Spungen, Ann M.] Mt Sinai Sch Med, Dept Rehabilitat Med, New York, NY USA. RP Post, JB (reprint author), James J Peters VA Med Ctr, 130 West Kingsbridge Rd, Bronx, NY 10468 USA. EM James.Post@va.gov FU VA RRD CDA 2 [B5050W]; VA RR&D Center of Excellence [B4162C] FX This project was funded by the VA RR&D CDA 2 #B5050W and VA RR&D Center of Excellence #B4162C. We would like to thank the kidney dialysis unit nursing staff for assisting with patient scheduling and communication. NR 30 TC 2 Z9 2 U1 1 U2 5 PU DUSTRI-VERLAG DR KARL FEISTLE PI DEISENHOFEN-MUENCHEN PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY SN 0301-0430 J9 CLIN NEPHROL JI Clin. Nephrol. PD MAY PY 2014 VL 81 IS 5 BP 313 EP 319 DI 10.5414/CN107998 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA AT2WQ UT WOS:000344795400002 PM 24780553 ER PT J AU Feeney, MP Stover, B Keefe, DH Garinis, AC Day, JE Seixas, N AF Feeney, M. Patrick Stover, Bert Keefe, Douglas H. Garinis, Angela C. Day, Jessica E. Seixas, Noah TI Sources of Variability in Wideband Energy Reflectance Measurements in Adults SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE Wideband acoustic immittance; energy or power reflectance; absorbance; middle ear; tympanometry ID MIDDLE-EAR DISORDERS; NORMAL-HEARING; OTOACOUSTIC EMISSIONS; ACOUSTIC-IMPEDANCE; OTOSCLEROTIC EARS; TYMPANOMETRY; COEFFICIENT; CHILDREN; INFANTS AB Background: Wideband acoustic immittance measurements of the middle ear, such as wideband energy reflectance (ER), can provide information about how the middle ear functions across the traditional audiometric frequency range. These measurements are being investigated as a new means of evaluating conductive hearing disorders, and studies have been reported on a number of middle-ear disorders. However, the normative database for wideband ER is still being developed, and more information is needed about sources of test variability. Purpose: The purpose of the present study was to evaluate sources of variability in wideband ER measurements at baseline and across annual tests for up to 5 yr in subjects with normal hearing. Study Sample: The main group consisted of 112 subjects (187 ears), 24 females and 88 males, with normal hearing and normal 0.226-kHz admittance tympanometry. An additional 24 adults with abnormal 0.226-kHz tympanometry provided baseline comparison data. Research Design: A longitudinal design was used in obtaining annual measurements of audiometry, tympanometry, and wideband ER at ambient pressure in adults. Data Collection and Analysis: Clinical audiometry and tympanometry data and 1/3-octave wideband ER measurements were obtained at baseline and annually for up to four additional tests. Descriptive statistics and t-tests were used to explore differences in 1/3-octave baseline ER measures in terms of subject age, test ear, sex, and clinical tympanometry. Longitudinal mixed-effects linear regression models at 1.0, 2.0, and 4.0 kHz were used to examine the different sources of variance affecting ER over time. Results: There were small but statistically significant mean differences in ER for baseline measurements as a function of ear, sex, and age. Compared with these results, data for 29 ears with abnormal 0.226-kHz tympanometry differed from mean normal data across a broad frequency range by as much as 20%. ER varied as a function of peak compensated static acoustic admittance (Y-tm) for measures at 1.0 kHz but was unrelated to Ytm at 2.0 and 4.0 kHz. ER also varied as a function of the test ear, with significantly higher ER on the left at 1.0 and 2.0 kHz, but was not significantly related to the test ear at 4.0 kHz. The standard deviation for test-retest variability was about 0.1 at each frequency, which is consistent with previous studies. Conclusions: Mean wideband ER at baseline showed small but significant differences related to sex, ear, and age. ER was significantly related to Y-tm at 1.0 kHz in the longitudinal data but not at 2.0 or 4.0 kHz and to the test ear at 1.0 and 2.0 kHz but not at 4.0 kHz. When evaluated at ambient pressure, ER for ears with negative middle-ear pressure was similar to that of ears with abnormally low Y-tm. Therefore it might be necessary to evaluate wideband acoustic immittance compensated for middle-ear pressure by using tympanometry to obtain an effective differential diagnosis of middle-ear disorders in adults. C1 [Feeney, M. Patrick; Garinis, Angela C.] Portland VA Med Ctr, NCRAR, Portland, OR 97239 USA. [Feeney, M. Patrick] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. [Feeney, M. Patrick] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA. [Stover, Bert] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. [Keefe, Douglas H.] Boys Town Natl Res Hosp, Omaha, NE 68131 USA. [Day, Jessica E.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA. RP Feeney, MP (reprint author), Portland VA Med Ctr, NCRAR, VA RR&D Natl Ctr Rehabilitat Auditory Res, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA. EM Patrick.Feeney@va.gov FU National Institute for Occupational Health and Safety of the US Centers for Disease Control and Prevention [5 R01 0H003912]; VA RRD award [C9230C] FX This research was funded by the National Institute for Occupational Health and Safety of the US Centers for Disease Control and Prevention, 5 R01 0H003912. Support for the first author was also provided by VA RR&D award C9230C. The content of this article does not represent the views of the Department of Veterans Affairs or of the United States Government. NR 30 TC 3 Z9 3 U1 2 U2 11 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 EI 2157-3107 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD MAY PY 2014 VL 25 IS 5 SI SI BP 449 EP 461 DI 10.3766/jaaa.25.5.4 PG 13 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA AQ7RX UT WOS:000343018000004 PM 25257719 ER PT J AU Feeney, MP Sanford, CA Putterman, DB AF Feeney, M. Patrick Sanford, Chris A. Putterman, Daniel B. TI Effects of Ear-Canal Static Pressure on Pure-Tone Thresholds and Wideband Acoustic Immittance SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE Wideband acoustic immittance; middle ear; conductive hearing loss; otitis media ID CONDUCTIVE HEARING-LOSS; REFLECTION COEFFICIENT; OTOACOUSTIC EMISSIONS; HUMAN INFANTS; IMPEDANCE; ADULTS; IDENTIFICATION; PRESSURIZATION; TYMPANOMETRY; ADMITTANCE AB Background: Wideband acoustic immittance (WAI) measures provide information about middle-ear function across the traditional audiometric frequency range from 0.25 to 8.0 kHz. Recent studies have found that WAI is effective in predicting the presence of conductive hearing loss (CHL). It is not known whether WAI can accurately estimate the degree of threshold shift caused by CHL. Purpose: The purpose of the present study was to evaluate the relationship between changes in puretone threshold and changes in wideband absorbance and acoustic conductance levels induced by positive and negative ear-canal static pressure. Study Sample: Twenty young adult subjects with normal hearing and a negative history of middle-ear disorders participated in the study. Data Collection and Analysis: Experimental pure-tone thresholds at 0.5 and 2.0 kHz were estimated by using a three-interval, three-alternative forced-choice adaptive psychometric procedure under three conditions: ambient ear-canal pressure, +200 daPa static pressure, and 200 daPa static pressure. Wideband absorbance and conductance were obtained in the same subjects by using a Welch Allyn prototype diagnostic middle ear analyzer. Changes in pure-tone threshold from the ambient pressure condition to the static pressure condition were evaluated by using a paired-samples t test and Pearson productmoment correlation. Results: Wideband middle-ear absorbance and conductance at ambient pressure in this study were consistent with published data in adults with normal hearing. The mean change in threshold at 0.5 and 2.0 kHz with +200 daPa or -200 daPa ear-canal static pressure was similar to the mean change in absorbance and conductance levels in the same conditions. However, there was one statistically significant difference between the shift in pure-tone threshold and the change in conductance level for the +200 daPa pressure condition for 2.0 kHz, with the change in threshold being 1.5 dB greater than the change in conductance level (t = 2.39, p = 0.03). In contrast to the good performance of WAI measures in predicting mean threshold shifts caused by ear-canal pressure, the shifts in WAI were not correlated with threshold shifts. Thus WAI was not well suited to predict individual threshold changes caused by ear-canal static pressure. Conclusions: For the conditions of this study, results suggest that mean change in absorbance or conductance level caused by ear-canal static pressure of +200 daPa or 200 daPa provides a good estimate of the change in pure-tone threshold in the same conditions. However, individual threshold change was not accurately predicted by the change in absorbance or conductance level. C1 [Feeney, M. Patrick; Putterman, Daniel B.] Portland VA Med Ctr, NCRAR, Portland, OR 97239 USA. [Feeney, M. Patrick; Putterman, Daniel B.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. [Feeney, M. Patrick] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA. [Sanford, Chris A.] Idaho State Univ, Dept Commun Sci & Disorders, Pocatello, ID 83209 USA. RP Feeney, MP (reprint author), Portland VA Med Ctr, NCRAR, 3710 SW US Vet Hosp Rd,P5-NCRAR, Portland, OR 97239 USA. EM Patrick.Feeney@va.gov FU VA RRD award [C9230C] FX Support for the first and last authors was provided by VA RR&D award C9230C. The content of this article does not represent the views of the Department of Veterans Affairs or the United States Government. NR 29 TC 0 Z9 0 U1 1 U2 5 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 EI 2157-3107 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD MAY PY 2014 VL 25 IS 5 SI SI BP 462 EP 470 DI 10.3766/jaaa.25.5.5 PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA AQ7RX UT WOS:000343018000005 PM 25257720 ER PT J AU Shaaban, AM Rezvani, M Elsayes, KM Baskin, H Mourad, A Foster, BR Jarboe, EA Menias, CO AF Shaaban, Akram M. Rezvani, Maryam Elsayes, Khaled M. Baskin, Henry, Jr. Mourad, Amr Foster, Bryan R. Jarboe, Elke A. Menias, Christine O. TI Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features SO RADIOGRAPHICS LA English DT Article ID MATURE CYSTIC TERATOMA; ENDODERMAL SINUS TUMOR; PSEUDO-MEIGS-SYNDROME; STRUMA OVARII; PATHOLOGICAL CORRELATION; CARCINOID-TUMORS; IMMUNOHISTOCHEMICAL ANALYSIS; DIFFERENTIAL-DIAGNOSIS; PREOPERATIVE DIAGNOSIS; IMMATURE TERATOMAS AB Ovarian malignant germ cell tumors (OMGCTs) are heterogeneous tumors that are derived from the primitive germ cells of the embryonic gonad. OMGCTs are rare, accounting for about 2.6% of all ovarian malignancies, and typically manifest in adolescence, usually with abdominal pain, a palpable mass, and elevated serum tumor marker levels, which may serve as an adjunct in the initial diagnosis, monitoring during therapy, and posttreatment surveillance. Dysgerminoma, the most common malignant germ cell tumor, usually manifests as a solid mass. Immature teratomas manifest as a solid mass with scattered foci of fat and calcifications. Yolk sac tumors usually manifest as a mixed solid and cystic mass. Capsular rupture or the bright dot sign, a result of increased vascularity and the formation of small vascular aneurysms, may be present. Embryonal carcinomas and polyembryomas rarely manifest in a pure form and are more commonly part of a mixed germ cell tumor. Some OMGCTs have characteristic features that allow a diagnosis to be confidently made, whereas others have nonspecific features, which make them difficult to diagnose. However, imaging features, the patient's age at presentation, and tumor markers may help establish a reasonable differential diagnosis. Malignant ovarian germ cell tumors spread in the same manner as epithelial ovarian neoplasms but are more likely to involve regional lymph nodes. Preoperative imaging may depict local extension, peritoneal disease, and distant metastases. Suspicious areas may be sampled during surgery. Because OMGCTs are almost always unilateral and are chemosensitive, fertility-sparing surgery is the standard of care. (C)RSNA, 2014. C1 [Shaaban, Akram M.; Rezvani, Maryam] Univ Utah, Dept Diagnost Radiol, Salt Lake City, UT 84132 USA. [Baskin, Henry, Jr.] Univ Utah, Dept Radiol, Primary Childrens Med Ctr, Salt Lake City, UT 84132 USA. [Elsayes, Khaled M.] Univ Texas MD Anderson Canc Ctr, Dept Radiol, Houston, TX 77030 USA. [Mourad, Amr] VA Pittsburgh Healthcare Syst, Dept Diagnost Radiol, Pittsburgh, PA USA. [Foster, Bryan R.] Oregon Hlth & Sci Univ, Dept Diagnost Radiol, Portland, OR 97201 USA. [Jarboe, Elke A.] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USA. [Menias, Christine O.] Mayo Clin, Dept Radiol, Scottsdale, AZ USA. RP Shaaban, AM (reprint author), Univ Utah, Dept Diagnost Radiol, 30 N 1900 E,Room 1A71, Salt Lake City, UT 84132 USA. EM akram.shaaban@hsc.utah.edu NR 84 TC 7 Z9 9 U1 3 U2 8 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD MAY-JUN PY 2014 VL 34 IS 3 BP 777 EP 801 DI 10.1148/rg.343130067 PG 25 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AP2PH UT WOS:000341915200018 PM 24819795 ER PT J AU Chen, LLK Baca, CB Choe, J Chen, JW Ayad, ME Cheng, EM AF Chen, Leo L. K. Baca, Christine B. Choe, Jessica Chen, James W. Ayad, Miriam E. Cheng, Eric M. TI Posttraumatic Epilepsy in Operation Enduring Freedom/Operation Iraqi Freedom Veterans SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; EMOTIONAL RISK-FACTORS; HEAD-INJURY; NONEPILEPTIC SEIZURES; CODES; ASCERTAINMENT; DIAGNOSIS; ACCURACY; DISORDER; VALIDITY AB Penetrating traumatic brain injury (TBI) is a well-established risk factor for post-traumatic epilepsy (PTE). However, many veterans in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) who suffer from TBI do so from blast injury, and its consequences are not fully known. Two neurologists performed a chart review to describe patterns of injury and health care among all 16 OEF/OIF veterans at the VA Greater Los Angeles Healthcare System who were assigned an outpatient diagnosis of both epilepsy and TBI in 2008-2009. All Veterans were male, and the mean age was 30 years. Blast exposure was the most common mechanism of TBI (81%). Although all Veterans were assigned a diagnosis code of seizures, the diagnosis of PTE was clinically confirmed in only 3 veterans. On the other hand, the diagnosis of post-traumatic stress disorder was confirmed in 81% of the sample and a diagnosis of nonepileptic seizures was suspected in 44% of the sample. Researchers who study PTE among the OEF/OIF population using administrative data also should perform chart reviews to account for the prevalence of psychogenic nonepileptic seizures. C1 [Chen, Leo L. K.] Kaiser Permanente Fdn Hosp, Dept Neurol, Sacramento, CA 95825 USA. [Chen, Leo L. K.] UC Davis Hlth Syst, Dept Neurol, Sacramento, CA 95817 USA. [Baca, Christine B.; Choe, Jessica] Univ Calif San Diego, Dept Neurol, San Diego, CA 92103 USA. [Baca, Christine B.; Choe, Jessica; Chen, James W.; Ayad, Miriam E.; Cheng, Eric M.] VA Greater Los Angeles Healthcare Syst, Dept Neurol, Los Angeles, CA 90073 USA. [Chen, James W.; Ayad, Miriam E.; Cheng, Eric M.] UCLA, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA. RP Chen, LLK (reprint author), Kaiser Permanente Fdn Hosp, Dept Neurol, 2025 Morse Ave, Sacramento, CA 95825 USA. FU VA Epilepsy Center of Excellence at VA Los Angeles; NIH/NINDS [K23NS058571] FX The study was supported by the VA Epilepsy Center of Excellence at VA Los Angeles. Dr. Cheng was supported by Career Development Award from NIH/NINDS (K23NS058571). NR 28 TC 5 Z9 5 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2014 VL 179 IS 5 BP 492 EP 496 DI 10.7205/MILMED-D-13-00413 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UL UT WOS:000340806400007 PM 24806494 ER PT J AU Lo-Ciganic, W Donohue, JM Thorpe, CT Thorpe, JM Perera, S Marcum, ZA Gellad, WF AF Lo-Ciganic, W. Donohue, J. M. Thorpe, C. T. Thorpe, J. M. Perera, S. Marcum, Z. A. Gellad, W. F. TI EXAMINING A THRESHOLD OF ADHERENCE TO ORAL HYPOGLYCEMIC AGENTS RELEVANT TO CLINICAL OUTCOMES IN DIABETES: A TREE-STRUCTURED SURVIVAL MODEL SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Lo-Ciganic, W.; Donohue, J. M.; Perera, S.; Marcum, Z. A.; Gellad, W. F.] Univ Pittsburgh, Pittsburgh, PA USA. [Thorpe, C. T.; Thorpe, J. M.] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Gellad, W. F.] RAND, VA Pittsburgh Hlth Care Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PDB88 BP A253 EP A253 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082001519 ER PT J AU Cerulli, C Kothari, CL Dichter, M Marcus, S Wiley, J Rhodes, KV AF Cerulli, Catherine Kothari, Catherine L. Dichter, Melissa Marcus, Steve Wiley, James Rhodes, Karin V. TI Victim Participation in Intimate Partner Violence Prosecution: Implications for Safety SO VIOLENCE AGAINST WOMEN LA English DT Article DE intimate partner violence; prosecution; safety ID DOMESTIC VIOLENCE; PROTECTION ORDERS; DECISION-MAKING; HEALTH-CARE; WOMEN; BARRIERS; ARREST; LEGAL; RISK; INTERVENTION AB Are intimate partner violence (IPV) victims safer if they use the criminal justice system? Concerns about perpetrator retaliation, in the face of data that protection orders can reduce future harm, make it important to understand how victim utilization (calling 911, talking to the prosecutor, and proceeding with prosecution) affects subsequent safety. We hypothesized participation would improve victims' safety, measured by decreases in subsequent IPV-related 911 calls and/or emergency department visits. Findings support contact with the prosecutor's office was associated with reduction in police-reported IPV, regardless of the victim's wish to proceed. Policy implications support pro-prosecution strategies coupled with victim contact. C1 [Cerulli, Catherine] Univ Rochester, Rochester, NY 14642 USA. [Kothari, Catherine L.] Western Michigan Univ, Kalamazoo, MI 49008 USA. [Dichter, Melissa; Marcus, Steve] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equity Res & Promot, Philadelphia, PA USA. [Marcus, Steve] Univ Penn, Philadelphia, PA 19104 USA. [Rhodes, Karin V.] Univ Penn, Sch Social Policy & Practice, Philadelphia, PA 19104 USA. [Wiley, James] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Cerulli, C (reprint author), Univ Rochester, Sch Med & Dent, 300 Crittenden Blvd, Rochester, NY 14642 USA. EM Catherine_Cerulli@urmc.rochester.edu NR 56 TC 2 Z9 2 U1 6 U2 19 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-8012 EI 1552-8448 J9 VIOLENCE AGAINST WOM JI Violence Against Women PD MAY PY 2014 VL 20 IS 5 BP 539 EP 560 DI 10.1177/1077801214535105 PG 22 WC Women's Studies SC Women's Studies GA AN8VC UT WOS:000340882200005 PM 24894959 ER PT J AU Corbelli, J Borrero, S Bonnema, R McNamara, M Kraemer, K Rubio, D Karpov, I McNeil, M AF Corbelli, Jennifer Borrero, Sonya Bonnema, Rachel McNamara, Megan Kraemer, Kevin Rubio, Doris Karpov, Irina McNeil, Melissa TI Physician Adherence to US Preventive Services Task Force Mammography Guidelines SO WOMENS HEALTH ISSUES LA English DT Article ID PRIMARY-CARE PHYSICIANS; BREAST-CANCER RISK; HEART-FAILURE; RECOMMENDATIONS; METAANALYSIS; MALPRACTICE; MANAGEMENT; ATTITUDES; SUPPORT; SYSTEMS AB Background: In 2009, the U.S. Preventive Services Task Force (USPSTF) guidelines for screening mammography changed significantly, and are now in direct conflict with screening guidelines of other major national organizations. The extent to which physicians in different primary care specialties adhere to current USPSTF guidelines is unknown. Methods: We conducted a cross-sectional web-based survey completed by 316 physicians in internal medicine, family medicine (FM), and gynecology (GYN) from February to April 2012. Survey items assessed respondents' breast cancer screening recommendations in women of different ages at average risk for breast cancer. We used descriptive statistics to generate response distribution for survey items, and logistic regression models to compare responses among specialties. Findings: The response rate was 55.0% (316/575). A majority of providers in internal medicine (65%), FM (64%), and GYN (92%) recommended breast cancer screening starting at age 40 versus 50. A majority of providers in internal medicine (77%), FM (74%), and GYN (98%) recommended annual versus biennial screening. Gynecologists were significantly more likely than both internists and family physicians to recommend initial mammography at age 40 (p <= .0001) and yearly mammography (p = .0003). There were no other differences by respondent demographic. Conclusions: Primary care providers, especially gynecologists, have not implemented USPSTF guidelines. The extent to which these findings may be driven by patient versus provider preferences should be explored. These findings suggest that patients are likely to receive conflicting breast cancer screening recommendations from different providers. Copyright (C) 2014 by the Jacobs Institute of Women's Health. Published by Elsevier Inc. C1 [Corbelli, Jennifer; Borrero, Sonya; Kraemer, Kevin; Rubio, Doris; McNeil, Melissa] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA USA. [Borrero, Sonya] VA Pittsburgh Healthcare Syst, Ctr Res Hlth Equ & Promot, Pittsburgh, PA USA. [Borrero, Sonya; Kraemer, Kevin; Rubio, Doris; Karpov, Irina] Univ Pittsburgh, Ctr Res Hlth Care, Pittsburgh, PA USA. [Bonnema, Rachel] Univ Nebraska Med Ctr, Div Gen Internal Med, Omaha, NE USA. [McNamara, Megan] Case Western Reserve Univ, Sch Med, Div Gen Internal Med, Cleveland, OH USA. [McNamara, Megan] Louis Stokes VA Healthcare Syst, Cleveland, OH USA. RP Corbelli, J (reprint author), 200 Lothrop St,MUH 9W-33, Pittsburgh, PA 15213 USA. EM corbellija@upmc.edu NR 48 TC 9 Z9 9 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 EI 1878-4321 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD MAY-JUN PY 2014 VL 24 IS 3 BP E313 EP E319 DI 10.1016/j.whi.2014.03.003 PG 7 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA AO1ZQ UT WOS:000341114600008 PM 24794545 ER PT J AU Craig, AD Dehlendorf, C Borrero, S Harper, CC Rocca, CH AF Craig, Amaranta D. Dehlendorf, Christine Borrero, Sonya Harper, Cynthia C. Rocca, Corinne H. TI Exploring Young Adults' Contraceptive Knowledge and Attitudes: Disparities by Race/Ethnicity and Age SO WOMENS HEALTH ISSUES LA English DT Article ID 2002 NATIONAL-SURVEY; LOW-INCOME WOMEN; UNITED-STATES; UNINTENDED PREGNANCY; FAMILY GROWTH; RISK; CHOICE; DISCONTINUATION; HEALTH; SAMPLE AB Background: Half of pregnancies in the United States are unintended, with the highest proportions occurring among Blacks, Hispanics, and teenagers. Understanding differences in knowledge and attitudes about contraception by race/ethnicity and age can improve efforts to reduce disparities in unintended pregnancy. Methods: This analysis used data from the 897 female respondents in National Survey of Reproductive and Contraceptive Knowledge, a survey exploring young adults' knowledge and attitudes about contraception and pregnancy. Bivariate and multivariate logistic regression analyses were used to assess racial/ethnic and age group differences in knowledge and attitudes about contraceptives. Findings: Hispanics and teenagers (aged 18-19) had lower awareness of available contraceptive methods, and lower knowledge about individual methods compared with White women and young adults (age 20-29). For example, Hispanics (74%) and teenagers (77%) were less likely to have heard of the intrauterine device (IUD) than were White women (90%) and young adults (90%), and were less likely to know that a woman experiencing side effects could switch brands of oral contraceptive pills (72% of Hispanics vs. 86% of White women; 76% of teenagers vs. 90% of young adults). Hispanics born outside the United States had lower knowledge about contraceptives than U.S.-born Hispanics. For example, foreign-born Hispanics were less likely than U.S.-born Hispanics to have heard of the IUD (59% vs. 82%) or the vaginal ring (55% vs. 95%). Conclusions: Lower contraceptive knowledge among teenagers and Hispanics, particularly immigrants, suggests the importance of disseminating family planning information to these women as one means to address disparities in unintended pregnancy. Copyright (C) 2014 by the Jacobs Institute of Women's Health. Published by Elsevier Inc. C1 [Craig, Amaranta D.; Dehlendorf, Christine] Univ Calif San Francisco, Dept Family & Community Med, San Francisco, CA 94143 USA. [Craig, Amaranta D.; Dehlendorf, Christine; Harper, Cynthia C.; Rocca, Corinne H.] Univ Calif San Francisco, Bixby Ctr Global Reprod Hlth, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA. [Borrero, Sonya] Univ Pittsburgh, Ctr Res Hlth Care, Pittsburgh, PA USA. [Borrero, Sonya] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. RP Craig, AD (reprint author), Univ Calif San Francisco, Dept Family & Community Med, 1001 Potrero Ave,Ward 22, San Francisco, CA 94143 USA. EM amaranta.craig@ucsf.edu FU NICHD NIH HHS [K23HD067197, 1R21HD068736-01A1, K23 HD067197, R21 HD068736]; NIMHD NIH HHS [R25 MD006832, R25MD006832] NR 40 TC 19 Z9 20 U1 4 U2 25 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 EI 1878-4321 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD MAY-JUN PY 2014 VL 24 IS 3 BP E281 EP E289 DI 10.1016/j.whi.2014.02.003 PG 9 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA AO1ZQ UT WOS:000341114600004 PM 24725755 ER PT J AU Graff, JN Puri, S Bifulco, CB Fox, BA Beer, TM AF Graff, Julie N. Puri, Sachin Bifulco, Carlo B. Fox, Bernard A. Beer, Tomasz M. TI Sustained Complete Response to CTLA-4 Blockade in a Patient with Metastatic, Castration-Resistant Prostate Cancer SO CANCER IMMUNOLOGY RESEARCH LA English DT Article ID DOSE-ESCALATION TRIAL; IMMUNOTHERAPY; IPILIMUMAB; ANTIGEN; MUTATIONS; HYDROLASE; MELANOMA AB We present the case of a man with metastatic, castration-resistant prostate cancer, who had a complete prostate-specific antigen (PSA) response after 2(1/2) doses of ipilimumab. His treatment course was complicated by diarrhea and autoimmune hepatitis, both of which resolved within 4 months. Sera and biopsy specimens were accessed, and sera from pretreatment and day 113 were analyzed. Augmented antibody responses were detected against 11 potential tumor antigens, with responses ranging from 5- to 20-fold in day 113 sera compared with baseline. Genes that were targets of a strong antibody response (arbitrarily set at 10-fold or greater increase) were analyzed by real-time PCR for expression in the tumor biopsy cDNA. Of the top 5 genes, only 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) could be identified in the amplified tumor biopsy cDNA. Using an antibody to HIBCH, immunohistochemical analysis documented strong expression of the protein. Together, these data suggest that an augmented antibody response to HIBCH, an antigen that was expressed by the patient's prostate cancer, could have contributed to the clinical response. After 16 months of PSA stability, he discontinued his androgen-suppression therapy. With the return of his testosterone, his PSA increased slightly, likely originating from his intact prostate. He has been disease free for the past 6 years without any additional therapy. (C) 2014 AACR. C1 [Graff, Julie N.] Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97239 USA. [Graff, Julie N.; Fox, Bernard A.; Beer, Tomasz M.] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97239 USA. [Fox, Bernard A.] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97239 USA. [Puri, Sachin; Bifulco, Carlo B.; Fox, Bernard A.] Providence Canc Ctr, Earle A Chiles Res Inst, Robert W Franz Canc Res Ctr, Portland, OR USA. [Bifulco, Carlo B.] Providence Hlth Syst, Dept Pathol, Portland, OR USA. RP Graff, JN (reprint author), Oregon Hlth & Sci Univ, 3303 SW Bond Ave,CH14R, Portland, OR 97239 USA. EM graffj@ohsu.edu FU Bristol-Myers Squibb FX C.B. Bifulco is a consultant/advisory board member for EMD/Serono. J.N. Graff, B.A. Fox, and T.M. Beer have received commercial research support from Bristol-Myers Squibb. NR 21 TC 9 Z9 9 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 2326-6066 EI 2326-6074 J9 CANCER IMMUNOL RES JI Cancer Immunol. Res. PD MAY PY 2014 VL 2 IS 5 BP 399 EP 403 DI 10.1158/2326-6066.CIR-13-0193 PG 5 WC Oncology; Immunology SC Oncology; Immunology GA AM7GT UT WOS:000340034200003 PM 24795352 ER PT J AU Spaccarelli, N Gharavi, M Saboury, B Cheng, G Rook, AH Alavi, A AF Spaccarelli, Natalie Gharavi, Mohammad Saboury, Babak Cheng, Gang Rook, Alain H. Alavi, Abass TI Role of F-18-fluorodeoxyglucose positron emission tomography imaging in the management of primary cutaneous lymphomas SO HELLENIC JOURNAL OF NUCLEAR MEDICINE LA English DT Review DE Lymphoma; Skin cancer; F-18-FDG-PET; Staging lymphoma; Lymphoma response to therapy; Recurrence ID T-CELL LYMPHOMA; NON-HODGKINS-LYMPHOMA; MYCOSIS-FUNGOIDES; FDG-PET/CT; COMPUTED-TOMOGRAPHY; PROGNOSTIC VALUE; SEZARY-SYNDROME; F-18 FLUORODEOXYGLUCOSE; INTERNATIONAL-SOCIETY; TREATMENT RESPONSE AB Primary cutaneous lymphomas (PCLs) include both cutaneous T-cell and B-cell lymphomas and comprise the second most common type of extra-nodal non-Hodgkin's lymphomas. The treatment and prognosis of PCLs typically depend on the extent of disease. In evaluating extent of disease in oncological processes, computed tomography (CT) provides a purely anatomical assessment of disease. In comparison, [F-18]-fluorodeoxyglucose positron emission tomography (F-18-FDG PET) both visualizes and quantifies the biological processes occurring in the disease at the cellular level. This paper reviews the available literature addressing the clinical role of F-18-FDG PET both alone and in combination with CT in PCLs and draws several conclusions. While F-18-FDG PET seems superior to CT in its detection of nodal and cutaneous PCL lesions,F-18-FDG PET does not seem to adequately detect erythroderma, plaque, or patch cutaneous PCL lesions. In addition, several case series have demonstrated that physicians may be able to use the semi-quantitative measurement of F-18-FDG uptake provided by F-18-FDG PET to predict which lesions are most aggressive. Other case series have shown that the integrated F-18-FDG PET/CT may provide an objective measure of treatment response in patients with PCLs. C1 [Spaccarelli, Natalie; Alavi, Abass] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Gharavi, Mohammad; Saboury, Babak; Alavi, Abass] Hosp Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA. [Cheng, Gang] Philadelphia Vet Affairs Med Ctr, Philadelphia, PA USA. [Rook, Alain H.] Hosp Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA. RP Alavi, A (reprint author), Hosp Univ Penn, 3400 Spruce St 4283, Philadelphia, PA 19104 USA. EM abass.alavi@uphs.upenn.edu NR 40 TC 4 Z9 4 U1 0 U2 1 PU HELLENIC SOC NUCLEAR MEDICINE PI THESSALONIKI PA 51 HERMU ST, THESSALONIKI, 546 23, GREECE SN 1790-5427 J9 HELL J NUCL MED JI Hell. J. Nucl. Med. PD MAY-AUG PY 2014 VL 17 IS 2 BP 78 EP 84 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AM7CZ UT WOS:000340023600002 PM 24997076 ER PT J AU La Fountaine, MF Cirnigliaro, CM Kirshblum, SC Galea, M Spungen, AM Bauman, WA AF La Fountaine, Michael F. Cirnigliaro, Christopher M. Kirshblum, Steven C. Galea, Marinella Spungen, Ann M. Bauman, William A. TI The Role of Severe Physical Inactivity on High Density Lipoprotein Particle Size and Number: Perspectives from NMR Spectroscopy in Persons with Chronic Spinal Cord Injury SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [La Fountaine, Michael F.] Seton Hall Univ, S Orange, NJ 07079 USA. [Cirnigliaro, Christopher M.; Galea, Marinella; Spungen, Ann M.; Bauman, William A.] James J Peters VA Med Ctr, Bronx, NY USA. [Kirshblum, Steven C.] Kessler Inst Rehabil, W Orange, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2372 BP 636 EP 636 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115904177 ER PT J AU Cirnigliaro, CM Dengel, DR Liu, J LaFountaine, MF Kirshblum, SC Galea, M Spungen, AM Bauman, WA AF Cirnigliaro, Christopher M. Dengel, Donald R. Liu, Ji LaFountaine, Michael F. Kirshblum, Steven C. Galea, Marinella Spungen, Ann M. Bauman, William A. TI Increased Visceral Fat in Persons with Spinal Cord Injury SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Cirnigliaro, Christopher M.; LaFountaine, Michael F.; Galea, Marinella; Spungen, Ann M.; Bauman, William A.] James J Peters VA Med Ctr, Bronx, NY USA. [Dengel, Donald R.] Univ Minnesota, Minneapolis, MN USA. [Liu, Ji] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA. [Kirshblum, Steven C.] Kessler Inst Rehabil, W Orange, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2940 BP 800 EP 800 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115905271 ER PT J AU La Fountaine, MF Toda, M Testa, A Bauman, WA AF La Fountaine, Michael F. Toda, Michita Testa, Anthony Bauman, William A. TI The Spontaneous Appearance Of Wandering Atrial Pacemaker And Frequent Atrial Ectopy Following Concussion SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [La Fountaine, Michael F.; Toda, Michita; Testa, Anthony] Seton Hall Univ, S Orange, NJ 07079 USA. [Bauman, William A.] James J Peters VA Med Ctr, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 3202 BP 865 EP 865 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115905458 ER PT J AU Sittig, DF Ash, JS Singh, H AF Sittig, Dean F. Ash, Joan S. Singh, Hardeep TI The SAFER Guides: Empowering Organizations to Improve the Safety and Effectiveness of Electronic Health Records SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID PROVIDER ORDER ENTRY; PATIENT-SAFETY; FOLLOW-UP; INFORMATICS; SYSTEMS AB Electronic health records (EHRs) have potential to improve quality and safety of healthcare. However, EHR users have experienced safety concerns from EHR design and usability features that are not optimally adapted for the complex work flow of real-world practice. Few strategies exist to address unintended consequences from implementation of EHRs and other health information technologies. We propose that organizations equipped with EHRs should consider the strategy of "proactive risk assessment" of their EHR-enabled healthcare system to identify and address EHR-related safety concerns. In this paper, we describe the conceptual underpinning of an EHR-related self-assessment strategy to provide institutions a foundation upon which they could build their safety efforts. With support from the Office of the National Coordinator for Health Information Technology (ONC), we used a rigorous, iterative process to develop a set of 9 self-assessment tools to optimize the safety and safe use of EHRs. These tools,referred to as the Safety Assurance Factors for EHR Resilience (SAFER) guides, could be used to self-assess safety and effectiveness of EHR implementations, identify specific areas of vulnerability, and create solutions and culture change to mitigate risks. A variety of audiences could conduct these assessments, including frontline clinicians or care teams in different practices, or clinical, quality, or administrative leaders within larger institutions. The guides use a multifaceted systems-based approach to assess risk and empower organizations to work with internal or external stakeholders (eg, EHR developers) on optimizing EHR functionality and using EHRs to drive improvements in the quality and safety of healthcare. C1 [Sittig, Dean F.] Univ Texas Hlth Sci Ctr Houston, Houstons Sch Biomed Informat, Houston, TX 77030 USA. [Sittig, Dean F.] UT Mem Hermann Ctr Healthcare Qual & Safety, Houston, TX 77030 USA. [Ash, Joan S.] Oregon Hlth & Sci Univ, Sch Med, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA. [Singh, Hardeep] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston Vet Adm Hlth Serv Res, Houston, TX 77030 USA. [Singh, Hardeep] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Dev Ctr Innovat Qual Effectiveness & Safety, Houston, TX 77030 USA. [Singh, Hardeep] Baylor Coll Med, Dept Med, Sect Hlth Serv Res, Houston, TX 77030 USA. RP Sittig, DF (reprint author), UT Mem Hermann Ctr Healthcare Qual & Safety, 6410 Fannin St,UTPB 1100-43, Houston, TX 77030 USA. EM dean.f.sittig@uth.tmc.edu FU Westat - Office of the National Coordinator for Health Information Technology (ONC) [HHSP-23320095655WC0095655, HH-SP23337003T]; Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development; Center for Innovations in Quality, Effectiveness and Safety [CIN 13-413] FX Source of Funding:. The SAFER project is supported through a subcontract from Westat (HHSP-23320095655WC0095655; Anticipating the Unintended Consequences of Health IT) funded by the Office of the National Coordinator for Health Information Technology (ONC) (HH-SP23337003T; to Drs Sittig, Ash, and Singh). Dr Singh was supported in part by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development and the Center for Innovations in Quality, Effectiveness and Safety (CIN 13-413). NR 32 TC 14 Z9 14 U1 2 U2 5 PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC PI PLAINSBORO PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD MAY PY 2014 VL 20 IS 5 BP 418 EP 423 PG 6 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AL5AV UT WOS:000339146800012 PM 25181570 ER PT J AU Barnett, PG Chow, A Joyce, VR Bayoumi, AM Griffin, SC Sun, H Holodniy, M Brown, ST Cameron, DW Sculpher, M Youle, M Anis, AH Owens, DK AF Barnett, Paul G. Chow, Adam Joyce, Vilija R. Bayoumi, Ahmed M. Griffin, Susan C. Sun, Huiying Holodniy, Mark Brown, Sheldon T. Cameron, D. William Sculpher, Mark Youle, Mike Anis, Aslam H. Owens, Douglas K. TI Effect of Management Strategies and Clinical Status on Costs of Care for Advanced HIV SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; HEALTH-CARE; LIFETIME COST; UNITED-STATES; ERA; EXPENDITURES; MEDICAID; PATTERNS; MODELS AB Objectives To determine the association between preexisting characteristics and current health and the cost of different types of advanced human immunodeficiency virus (HIV) care. Methods Treatment-experienced patients failing highly active antiretroviral treatment (ART) in the United States, Canada, and the United Kingdom were factorial randomized to an antiretroviral-free period and ART intensification. Cost was estimated by multiplying patient-reported utilization by a unit cost. Results A total of 367 participants were followed for a mean of 15.3 quarters (range 1-26). Medication accounted for most (61.8%) of the $26,832 annual cost. Cost averaged $4147 per quarter for ART, $1981 for inpatient care, $580 for outpatient care, and $346 for other medications. Cost for inpatient stays, outpatient visits, and other medications was 171% higher (P<.01) and cost of ART was 32% lower (P<.01) when cluster of differentiation 4 (CD4) count was <50 cells/mu L compared with periods when CD4 count was >200 cells/mu L. Some baseline characteristics, including low CD4 count, high viral load, and HIV from injection drug use with hepatitis C coinfection, had a sustained effect on cost. Conclusions The association between health status and cost depended on the type of care. Indicators of poor health were associated with higher inpatient and concomitant medication costs and lower cost for ART medication. Although ART has supplanted hospitalization as the most important cost in HIV care, some patients continue to incur high hospitalization costs in periods when they are using less ART. The cost of interventions to improve the use of ART might be offset by the reduction of other costs. C1 [Barnett, Paul G.; Chow, Adam; Joyce, Vilija R.] VA HSR&D Hlth Econ Res Ctr, VA Palo Alto Healthcare Syst, VA Cooperative Studies Program, Menlo Pk, CA 94025 USA. [Bayoumi, Ahmed M.] St Michaels Hosp, Ctr Res Inner City Hlth, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON, Canada. [Bayoumi, Ahmed M.] St Michaels Hosp, Div Gen Internal Med, Toronto, ON, Canada. [Bayoumi, Ahmed M.] Univ Toronto, Dept Med, Dept Hlth Policy, Dept Management & Evaluat, Toronto, ON, Canada. [Griffin, Susan C.; Sculpher, Mark] Univ York, Ctr Hlth Econ, York, N Yorkshire, England. [Holodniy, Mark; Owens, Douglas K.] VA Palo Alto Healthcare Syst, Palo Alto, CA USA. [Owens, Douglas K.] Stanford Univ, Ctr Primary Care & Outcomes Res, Ctr Hlth Policy, Stanford, CA USA. [Brown, Sheldon T.] James J Peters VA Med Ctr, Bronx, NY USA. [Cameron, D. William] Univ Ottawa, Ottawa Hosp, Div Infect Dis, Ottawa, ON, Canada. [Youle, Mike] Royal Free Hosp, London, England. [Sun, Huiying; Anis, Aslam H.] CIHR, Canadian HIV Trials Network, Vancouver, BC, Canada. [Anis, Aslam H.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada. RP Barnett, PG (reprint author), HERC, VA Palo Alto Hlth Care Syst, 795 Willow Rd 152, Menlo Pk, CA 94025 USA. EM paul.barnett@va.gov RI Joyce, Vilija/A-2578-2013 OI Joyce, Vilija/0000-0002-2484-4625 FU US Department of Veterans Affairs Cooperative Studies Program; United Kingdom Medical Research Council; Canadian Institutes for Health Research FX Source of Funding: US Department of Veterans Affairs Cooperative Studies Program, the United Kingdom Medical Research Council, and the Canadian Institutes for Health Research. NR 36 TC 2 Z9 2 U1 0 U2 2 PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC PI PLAINSBORO PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD MAY PY 2014 VL 20 IS 5 BP E129 EP E137 PG 9 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AL5AV UT WOS:000339146800002 PM 25326927 ER PT J AU Cerimele, JM Halperin, AC Saxon, AJ AF Cerimele, Joseph M. Halperin, Abigail C. Saxon, Andrew J. TI Tobacco Use Treatment in Primary Care Patients with Psychiatric Illness SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article DE Mental Disorders; Tobacco Use Cessation ID SMOKING-CESSATION PHARMACOTHERAPIES; RANDOMIZED CLINICAL-TRIAL; SEVERE MENTAL-ILLNESS; BIPOLAR DISORDER; CIGARETTE-SMOKING; MAJOR DEPRESSION; ANXIETY DISORDERS; HEALTH-SERVICES; UNITED-STATES; QUIT DAY AB The prevalence of smoking is higher in patients with psychiatric illness compared with the general population. Smoking causes chronic illnesses, which lead to premature mortality in those with psychiatric illness, is associated with greater burden of psychiatric symptoms, and contributes to the social isolation experienced by individuals with psychiatric disorders. Most patients with a psychiatric illness present initially to primary care rather than specialty care settings, and some patients receive care exclusively in the primary care setting. Therefore, family physicians and other primary care clinicians have an important role in the recognition and treatment of tobacco use disorders in patients with psychiatric illnesses. In this article we review common myths associated with smoking and psychiatric illness, techniques for implementing evidence-based tobacco use treatments, the evidence base for tobacco use treatment for patients with specific psychiatric diagnoses, and factors to consider when treating tobacco use disorders in patients with psychiatric illness. C1 [Cerimele, Joseph M.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Halperin, Abigail C.] Univ Washington, Sch Med, Dept Family Med, Seattle, WA 98195 USA. [Halperin, Abigail C.] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Seattle, WA 98195 USA. [Saxon, Andrew J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. RP Cerimele, JM (reprint author), Univ Washington, Sch Med, Dept Psychiat & Behav Sci, 1959 NE Pacific St,Box 356560, Seattle, WA 98195 USA. EM cerimele@uw.edu FU National Institute of Mental Health [T-32 MH020021-16] FX JMC is supported by a grant from the National Institute of Mental Health (T-32 MH020021-16). NR 72 TC 3 Z9 4 U1 4 U2 12 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 EI 1558-7118 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD MAY-JUN PY 2014 VL 27 IS 3 BP 399 EP 410 DI 10.3122/jabfm.2014.03.130252 PG 12 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AL5IL UT WOS:000339167000015 PM 24808119 ER PT J AU Wang, J Mathalon, DH Roach, BJ Reilly, J Keedy, SK Sweeney, JA Ford, JM AF Wang, Jun Mathalon, Daniel H. Roach, Brian J. Reilly, James Keedy, Sarah K. Sweeney, John A. Ford, Judith M. TI Action planning and predictive coding when speaking SO NEUROIMAGE LA English DT Article DE Corollary discharge; Efference copy; IFG; STG ID HUMAN AUDITORY-CORTEX; COROLLARY DISCHARGE DYSFUNCTION; SPEECH PRODUCTION; NEUROMAGNETIC RESPONSES; OWN VOICE; SCHIZOPHRENIA; FEEDBACK; EEG; DYNAMICS; SOUNDS AB Across the animal kingdom, sensations resulting from an animal's own actions are processed differently from sensations resulting from external sources, with self-generated sensations being suppressed. A forward model has been proposed to explain this process across sensorimotor domains. During vocalization, reduced processing of one's own speech is believed to result from a comparison of speech sounds to corollary discharges of intended speech production generated from efference copies of commands to speak. Until now, anatomical and functional evidence validating this model in humans has been indirect. Using EEG with anatomical MRI to facilitate source localization, we demonstrate that inferior frontal gyrus activity during the 300 ms before speaking was associated with suppressed processing of speech sounds in auditory cortex around 100 ms after speech onset (N1). These findings indicate that an efference copy from speech areas in prefrontal cortex is transmitted to auditory cortex, where it is used to suppress processing of anticipated speech sounds. About 100 ms after N1, a subsequent auditory cortical component (P2) was not suppressed during talking. The combined N1 and P2 effects suggest that although sensory processing is suppressed as reflected in N1, perceptual gaps may be filled as reflected in the lack of P2 suppression, explaining the discrepancy between sensory suppression and preserved sensory experiences. These findings, coupled with the coherence between relevant brain regions before and during speech, provide new mechanistic understanding of the complex interactions between action planning and sensory processing that provide for differentiated tagging and monitoring of one's own speech, processes disrupted in neuropsychiatric disorders. Published by Elsevier Inc. C1 [Wang, Jun; Sweeney, John A.] Univ Texas Southwestern, Dept Psychiat, Dallas, TX 75390 USA. [Mathalon, Daniel H.; Roach, Brian J.; Ford, Judith M.] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Mathalon, Daniel H.; Ford, Judith M.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94121 USA. [Reilly, James] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA. [Keedy, Sarah K.] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA. RP Ford, JM (reprint author), San Francisco VA Med Ctr, Psychiat Serv 116D, 4150 Clement St, San Francisco, CA 94121 USA. EM Judith.ford@ucsf.edu RI Keedy, Sarah/H-6557-2014 OI Keedy, Sarah/0000-0002-2139-9271; Roach, Brian/0000-0002-3264-1465 FU NIMH [MH077862, MH085485, MH058262] FX This work was supported by grants from NIMH MH077862, MH085485, and MH058262. We thank Brett Clementz for comments on an early draft. NR 62 TC 15 Z9 15 U1 6 U2 19 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD MAY 1 PY 2014 VL 91 BP 91 EP 98 DI 10.1016/j.neuroimage.2014.01.003 PG 8 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA AL1VJ UT WOS:000338914100011 PM 24423729 ER PT J AU Johnson, HM Thorpe, CT Bartels, CM Schumacher, JR Palta, M Pandhi, N Sheehy, AM Smith, MA AF Johnson, Heather M. Thorpe, Carolyn T. Bartels, Christie M. Schumacher, Jessica R. Palta, Mari Pandhi, Nancy Sheehy, Ann M. Smith, Maureen A. TI Antihypertensive Medication Initiation Among Young Adults with Regular Primary Care Use SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE hypertension; ambulatory care; disease management ID BLOOD-PRESSURE; UNITED-STATES; CARDIOVASCULAR-DISEASE; HYPERTENSION TREATMENT; ADMINISTRATIVE DATA; DRUG-THERAPY; RISK-FACTORS; IMPACT; COMORBIDITIES; OPPORTUNITIES AB BACKGROUND: Young adults with hypertension have the lowest prevalence of controlled blood pressure compared to middle-aged and older adults. Uncontrolled hypertension, even among young adults, increases future cardiovascular event risk. However, antihypertensive medication initiation is poorly understood among young adults and may be an important intervention point for this group. OBJECTIVE: The purpose of this study was to compare rates and predictors of antihypertensive medication initiation between young adults and middle-aged and older adults with incident hypertension and regular primary care contact. DESIGN: A retrospective analysis PARTICIPANTS: Adults >= 18 years old (n=10,022) with incident hypertension and no prior antihypertensive prescription, who received primary care at a large, Midwestern, academic practice from 2008-2011. MAIN MEASURES: The primary outcome was time from date of meeting hypertension criteria to antihypertensive medication initiation, or blood pressure normalization without medication. Kaplan-Meier analysis was used to estimate the probability of antihypertensive medication initiation over time. Cox proportional-hazard models (HR; 95 % CI) were fit to identify predictors of delays in medication initiation, with a subsequent subpopulation analysis for young adults (18-39 years old). KEY RESULTS: After a mean follow-up of 20 (+/- 13) months, 34 % of 18-39 year-olds with hypertension met the endpoint, compared to 44 % of 40-59 year-olds and 56 % of >= 60 year-olds. Adjusting for patient and provider factors, 18-39 year-olds had a 44 % slower rate of medication initiation (HR 0.56; 0.47-0.67) than >= 60 year-olds. Among young adults, males, patients with mild hypertension, and White patients had a slower rate of medication initiation. Young adults with Medicaid and more clinic visits had faster rates. CONCLUSIONS: Even with regular primary care contact and continued elevated blood pressure, young adults had slower rates of antihypertensive medication initiation than middle-aged and older adults. Interventions are needed to address multifactorial barriers contributing to poor hypertension control among young adults. C1 [Johnson, Heather M.; Bartels, Christie M.; Sheehy, Ann M.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53792 USA. [Johnson, Heather M.; Bartels, Christie M.; Schumacher, Jessica R.; Pandhi, Nancy; Sheehy, Ann M.; Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Hlth Innovat Program, Madison, WI 53792 USA. [Thorpe, Carolyn T.] Vet Affairs Pittsburgh Healthcare Syst, Hlth Serv Res & Dev, Pittsburgh, PA USA. [Thorpe, Carolyn T.] Univ Pittsburgh, Sch Pharm, Dept Pharm & Therapeut, Pittsburgh, PA 15261 USA. [Schumacher, Jessica R.; Palta, Mari; Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI 53792 USA. [Palta, Mari] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53792 USA. [Pandhi, Nancy; Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Family Med, Madison, WI 53792 USA. [Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Madison, WI 53792 USA. [Johnson, Heather M.] Univ Wisconsin, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI 53792 USA. RP Johnson, HM (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, Div Cardiovasc Med, H4-512 CSC,MC 3248,600 Highland Ave, Madison, WI 53792 USA. EM hm2@medicine.wisc.edu OI Johnson, Heather/0000-0002-4916-3519 FU Clinical and Translational Science Award (CTSA) program [UL1RR025011]; National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health [U54TR000021]; National Heart, Lung, and Blood Institute of the National Institutes of Health [K23HL112907]; University of Wisconsin Centennial Scholars Program of the University of Wisconsin School of Medicine and Public Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [K23AR062381]; National Institute on Aging of the National Institutes of Health [K08AG029527]; University of Wisconsin Health Innovation Program; University of Wisconsin School of Medicine and Public Health from The Wisconsin Partnership Program FX Research reported in this manuscript was supported by the Clinical and Translational Science Award (CTSA) program, previously through the National Center for Research Resources (NCRR) under award number UL1RR025011, and now by the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health under award number U54TR000021. Heather Johnson is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number K23HL112907, and also by the University of Wisconsin Centennial Scholars Program of the University of Wisconsin School of Medicine and Public Health. Christie Bartels is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number K23AR062381. Nancy Pandhi is supported by the National Institute on Aging of the National Institutes of Health under award number K08AG029527. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.; Additional funding for this project was provided by the University of Wisconsin Health Innovation Program and the University of Wisconsin School of Medicine and Public Health from The Wisconsin Partnership Program. NR 42 TC 11 Z9 11 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2014 VL 29 IS 5 BP 723 EP 731 DI 10.1007/s11606-014-2790-4 PG 9 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VL UT WOS:000338205700012 PM 24493322 ER PT J AU Sen, AP Sewell, TB Riley, EB Stearman, B Bellamy, SL Hu, MF Tao, YY Zhu, JS Park, JD Loewenstein, G Asch, DA Volpp, KG AF Sen, Aditi P. Sewell, Taylor B. Riley, E. Brooks Stearman, Beth Bellamy, Scarlett L. Hu, Michelle F. Tao, Yuanyuan Zhu, Jingsan Park, James D. Loewenstein, George Asch, David A. Volpp, Kevin G. TI Financial Incentives for Home-Based Health Monitoring: A Randomized Controlled Trial SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE chronic disease; health information technology; health behavior; disease management; adherence ID IMPROVE WARFARIN ADHERENCE; LONGITUDINAL DATA-ANALYSIS; DIABETIC-PATIENTS; HEART-FAILURE; BLOOD-GLUCOSE; WEIGHT-LOSS; LOTTERY; INSULIN; REWARD; REGRET AB BACKGROUND: Home wireless device monitoring could play an important role in improving the health of patients with poorly controlled chronic diseases, but daily engagement rates among these patients may be low. OBJECTIVE: To test the effectiveness of two different magnitudes of financial incentives for improving adherence to remote-monitoring regimens among patients with poorly controlled diabetes. DESIGN: Randomized, controlled trial. (Clinicaltrials.govIdentifier: NCT01282957). PARTICIPANTS: Seventy-five patients with a hemoglobin A1c greater than or equal to 7.5 % recruited from a Primary Care Medical Home practice at the University of Pennsylvania Health System. INTERVENTIONS: Twelve weeks of daily home-monitoring of blood glucose, blood pressure, and weight (control group; n=28); a lottery incentive with expected daily value of $2.80 (n=26) for daily monitoring; and a lottery incentive with expected daily value of $1.40 (n=21) for daily monitoring. MAIN MEASURES: Daily use of three home-monitoring devices during the three-month intervention (primary outcome) and during the three-month follow-up period and change in A1c over the intervention period (secondary outcomes). KEY RESULTS: Incentive arm participants used devices on a higher proportion of days relative to control (81 % low incentive vs. 58 %, P=0.007; 77 % high incentive vs. 58 %, P=0.02) during the three-month intervention period. There was no difference in adherence between the two incentive arms (P=0.58). When incentives were removed, adherence in the high incentive arm declined while remaining relatively high in the low incentive arm. In month 6, the low incentive arm had an adherence rate of 62 % compared to 35 % in the high incentive arm (P=0.015) and 27 % in the control group (P=0.002). CONCLUSIONS: A daily lottery incentive worth $1.40 per day improved monitoring rates relative to control and had significantly better efficacy once incentives were removed than a higher incentive. C1 [Sen, Aditi P.; Stearman, Beth; Tao, Yuanyuan; Zhu, Jingsan; Loewenstein, George; Asch, David A.; Volpp, Kevin G.] Penn CMU Roybal P30 Ctr Behav Econ & Hlth, Philadelphia, PA USA. [Sen, Aditi P.; Stearman, Beth; Tao, Yuanyuan; Zhu, Jingsan; Loewenstein, George; Asch, David A.; Volpp, Kevin G.] Leonard Davis Inst Ctr Hlth Incent & Behav Econ, Philadelphia, PA USA. [Sen, Aditi P.; Sewell, Taylor B.; Asch, David A.; Volpp, Kevin G.] Univ Penn, Wharton Sch, Dept Hlth Care Management, Philadelphia, PA 19104 USA. [Sewell, Taylor B.; Riley, E. Brooks; Hu, Michelle F.; Tao, Yuanyuan; Zhu, Jingsan; Park, James D.; Asch, David A.; Volpp, Kevin G.] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA. [Stearman, Beth] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Bellamy, Scarlett L.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Park, James D.] Rutgers, Robert Wood Johnson Med Sch, Camden, NJ USA. [Loewenstein, George] Carnegie Mellon Univ, Dept Social & Decis Sci, Pittsburgh, PA 15213 USA. [Asch, David A.; Volpp, Kevin G.] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. RP Sen, AP (reprint author), Univ Penn, Wharton Sch, Dept Hlth Care Management, 3461 Locust Walk, Philadelphia, PA 19104 USA. EM Aditisen@wharton.upenn.edu OI Asch, David/0000-0002-7970-286X FU National Institute on Aging [RC2AG036592, P30AG034546] FX This work was supported by grants RC2AG036592 and P30AG034546 from the National Institute on Aging. NR 26 TC 12 Z9 12 U1 3 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2014 VL 29 IS 5 BP 770 EP 777 DI 10.1007/s11606-014-2778-0 PG 8 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VL UT WOS:000338205700018 PM 24522623 ER PT J AU Yano, EM AF Yano, Elizabeth M. TI Teaching Commentary on "A Primary Care-Based Multidisciplinary Readmission Prevention Program": Essential Aspects of Comparability and Context in Practice-Based Program Evaluation SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material ID HEALTH-CARE; IMPLEMENTATION; SCIENCE C1 [Yano, Elizabeth M.] VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, Sepulveda, CA 91343 USA. [Yano, Elizabeth M.] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Hlth Policy & Management, Los Angeles, CA USA. RP Yano, EM (reprint author), VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, 16111 Plummer St,Mailcode 152, Sepulveda, CA 91343 USA. EM Elizabeth.yano@va.gov NR 22 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2014 VL 29 IS 5 BP 805 EP 807 DI 10.1007/s11606-014-2820-2 PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VL UT WOS:000338205700026 PM 24627269 ER PT J AU Chiovaro, J Douglas, V Gaggar, A Dhaliwal, G AF Chiovaro, Joseph Douglas, Vanja Gaggar, Anuj Dhaliwal, Gurpreet TI Exhausting the Differential SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material DE cerebral aneurysms; motor weakness; dyspnea ID PROBLEM REPRESENTATION; MYASTHENIA-GRAVIS; SIGN-OUT; STRATEGIES; RECOMMENDATIONS; QUALITY; CARE C1 [Chiovaro, Joseph] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA. [Chiovaro, Joseph] Portland VA Med Ctr, Portland, OR USA. [Douglas, Vanja] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Gaggar, Anuj; Dhaliwal, Gurpreet] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Dhaliwal, Gurpreet] San Francisco VA Med Ctr, San Francisco, CA USA. RP Chiovaro, J (reprint author), P3 Med Portland VA Med Ctr, Dept Med, 3710 Southwest US Vet Hosp Rd, Portland, OR 97239 USA. EM jchiovaro@gmail.com NR 13 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2014 VL 29 IS 5 BP 808 EP 812 DI 10.1007/s11606-013-2730-8 PG 5 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VL UT WOS:000338205700027 PM 24395100 ER PT J AU Rhee, C Moradi, H Brunelli, S Jing, JN Nakata, T Nguyen, D Kovesdy, C Brent, G Kalantar-Zadeh, K AF Rhee, Connie Moradi, Hamid Brunelli, Steven Jing, Jennie Nakata, Tracy Danh, Nguyen Kovesdy, Csaba Brent, Gregory Kalantar-Zadeh, Kamyar TI ASSOCIATION BETWEEN ADIPONECTIN AND MORTALITY IN HEMODIALYSIS PATIENTS FROM THE MADRAD STUDY SO NEPHROLOGY DIALYSIS TRANSPLANTATION LA English DT Meeting Abstract CT 51st Congress of the European-Renal-Association(ERA)/European-Dialysis-and-Transplant-Associa tion (EDTA) CY MAY 31-JUN 03, 2014 CL Amsterdam, NETHERLANDS SP European Renal Assoc, European Dialysis & Transplant Assoc C1 [Rhee, Connie; Moradi, Hamid; Jing, Jennie; Nakata, Tracy; Danh, Nguyen; Kalantar-Zadeh, Kamyar] Univ Calif Irvine, Orange, CA 92668 USA. [Brunelli, Steven] Brigham & Womens Hosp, Boston, MA 02115 USA. [Kovesdy, Csaba] Memphis VA Med Ctr, Memphis, TN USA. [Brent, Gregory] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0931-0509 EI 1460-2385 J9 NEPHROL DIAL TRANSPL JI Nephrol. Dial. Transplant. PD MAY PY 2014 VL 29 SU 3 MA SP604 BP 274 EP 274 PG 1 WC Transplantation; Urology & Nephrology SC Transplantation; Urology & Nephrology GA AJ9FQ UT WOS:000338013501083 ER PT J AU Vistamehr, A Kautz, SA Neptune, RR AF Vistamehr, Arian Kautz, Steven A. Neptune, Richard R. TI The influence of solid ankle-foot-orthoses on forward propulsion and dynamic balance in healthy adults during walking SO CLINICAL BIOMECHANICS LA English DT Article DE Gait; Orthotic; AFO; Angular momentum; Biomechanics ID PLANE ANGULAR-MOMENTUM; HEMIPARETIC PATIENTS; MUSCLE CONTRIBUTIONS; HEMIPLEGIC PATIENTS; FRONTAL-PLANE; PUSH-OFF; GAIT; BODY; PROGRESSION; SUPPORT AB Background: In post-stroke hemiparetic subjects, solid polypropylene ankle-foot-orthoses are commonly prescribed to assist in foot clearance during swing while bracing the ankle during stance. Mobility demands, such as changing walking speed and direction, are accomplished by accelerating or decelerating the body and maintaining dynamic balance. Previous studies have shown that the ankle plantarflexors are primary contributors to these essential biomechanical functions. Thus, with ankle-foot-orthoses limiting ankle motion and plantarflexor output during stance, execution of these walking subtasks may be compromised. This study examined the influence of a solid polypropylene ankle-foot-orthosis on forward propulsion and dynamic balance in healthy adults. Methods: Kinematic and kinetic data were recorded from 10 healthy adults walking with and without a unilateral ankle-foot-orthosis at steady-state slow (0.6 m/s) and moderate (1.2 m/s) speeds, and during accelerated (0-1.8 m/s at 0.06 m/s(2)) and decelerated (1.8-0 m/s at - 0.06 m/s(2)) walking. Propulsion was quantified by propulsive and braking impulses (i.e., time integral of the anterior-posterior ground reaction force) while dynamic balance was quantified by the peak-to-peak range of whole-body angular momentum. Findings: The propulsive impulses decreased in the leg with ankle-foot-orthosis compared to the contralateral leg and no ankle-foot-orthosis condition. Further, the ankle-foot-orthosis resulted in a greater range of angular momentum in both the frontal and sagittal planes, which were correlated with the reduced peak hip abduction and reduced ankle plantarflexor moments, respectively. Interpretation: Solid ankle-foot-orthoses limit the successful execution of important mobility subtasks in healthy adults and that the prescription of ankle-foot-orthosis should be carefully considered. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Vistamehr, Arian; Neptune, Richard R.] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA. [Kautz, Steven A.] Med Univ S Carolina, Dept Hlth Sci & Res, Charleston, SC 29425 USA. [Kautz, Steven A.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. RP Neptune, RR (reprint author), Univ Texas Austin, Dept Mech Engn, 204 E Dean Keeton St,Stop C2200, Austin, TX 78712 USA. EM rneptune@mail.utexas.edu OI Kautz, Steven/0000-0003-3151-8235 FU American Heart Association SouthWest Affiliate pre-doctoral fellowship [12PRE12030414]; Ralph H. Johnson VA Medical Center; Office of Research and Development, Rehabilitation Research and Development, U.S. Department of Veterans Affairs FX The authors are grateful to the members of the Locomotion Energetics and Assessment Lab in the Center for Rehabilitation Research in Neurological Conditions at the Medical University of South Carolina for their help with subject recruitment and data collection. This work was supported by an American Heart Association SouthWest Affiliate pre-doctoral fellowship (12PRE12030414) and supported in part by the Ralph H. Johnson VA Medical Center and the Office of Research and Development, Rehabilitation Research and Development, U.S. Department of Veterans Affairs. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the AHA or the VA. NR 35 TC 4 Z9 5 U1 4 U2 29 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD MAY PY 2014 VL 29 IS 5 BP 583 EP 589 DI 10.1016/j.clinbiomech.2014.02.007 PG 7 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA AJ7MN UT WOS:000337880900017 PM 24698166 ER PT J AU Bowles, DW McDermott, JD Jimeno, A AF Bowles, Daniel W. McDermott, Jessica D. Jimeno, Antonio TI Novel treatments for head and neck squamous cell carcinoma: preclinical identification and clinical investigation SO FUTURE ONCOLOGY LA English DT Review DE c-MET; EGFR; head and neck squamous cell carcinoma; Hedgehog; human papillomavirus; immunotherapy; Notch; PI3K; tyrosine kinase inhibitors ID GROWTH-FACTOR RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; REGULATORY T-CELLS; PHASE-II TRIAL; HUMAN-PAPILLOMAVIRUS INFECTION; CHEMOTHERAPY PLUS CETUXIMAB; ADVANCED SOLID TUMORS; HPV-ASSOCIATED HEAD; OROPHARYNGEAL CANCER; C-MET AB Head and neck squamous cell carcinoma (HNSCC) is a common cancer worldwide. Classically, it is a disease related to tobacco and alcohol use; an increasing number of patients are being diagnosed with HNSCC caused by infection with the human papillomavirus. New deep-sequencing techniques have confirmed the importance of p53 and EGF receptor in HNSCC development, and have identified pathways of critical importance, such as PI3K/mTOR and NOTCH. Increasing knowledge of key molecular features has lead to new therapeutic avenues for HNSCC. Novel therapies under investigation in HNSCC include antibody and small molecule inhibitors of EGF receptor and its family members, PI3K inhibitors, antiangiogenic agents, immunotherapies and agents interacting with early developmental pathways such as Hedgehog. C1 [Bowles, Daniel W.; McDermott, Jessica D.; Jimeno, Antonio] Univ Colorado, Div Med Oncol, Sch Med, Boulder, CO 80309 USA. [Bowles, Daniel W.] Eastern Colorado Hlth Care Syst, Denver Vet Affairs Med Ctr, Denver, CO USA. RP Jimeno, A (reprint author), Univ Colorado, Div Med Oncol, Sch Med, Boulder, CO 80309 USA. EM antonio.jimeno@ucdenver.edu NR 161 TC 4 Z9 5 U1 1 U2 6 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1479-6694 EI 1744-8301 J9 FUTURE ONCOL JI Future Oncol. PD MAY PY 2014 VL 10 IS 6 BP 1065 EP 1080 DI 10.2217/fon.14.18 PG 16 WC Oncology SC Oncology GA AJ8FO UT WOS:000337938300020 PM 24941990 ER PT J AU Suhler, EB Lim, LL Beardsley, RM Giles, TR Pasadhilka, S Lee, ST Saint Sardos, AD Butler, NJ Smith, JR Rosenbaum, JT AF Suhler, Eric B. Lim, Lyndell L. Beardsley, Robert M. Giles, Tracy R. Pasadhilka, Sirichai Lee, Shelly T. Saint Sardos, Alexandre de Butler, Nicholas J. Smith, Justine R. Rosenbaum, James T. TI Rituximab Therapy for Refractory Orbital Inflammation Results of a Phase 1/2, Dose-Ranging, Randomized Clinical Trial SO JAMA OPHTHALMOLOGY LA English DT Article ID RHEUMATOID-ARTHRITIS; EYE DISEASE; EFFICACY; MANAGEMENT; CYCLOPHOSPHAMIDE; VASCULITIS; RADIATION; SAFETY AB IMPORTANCE Orbital inflammation is a potentially blinding and disfiguring disease process that is often treated with systemic corticosteroids and immunosuppression; better treatments are needed. OBJECTIVE To determine whether rituximab, a monoclonal antibody against the B-lymphocyte antigen CD20, is effective in the treatment of refractory orbital inflammation. DESIGN, SETTING, AND PARTICIPANTS A dose-ranging, randomized, double-masked phase 1/2 clinical trial was conducted at a tertiary referral ophthalmology clinic. Ten individuals with orbital inflammation refractory to systemic corticosteroids and at least 1 other immunosuppressive agent were enrolled from January 2007 to March 2010. INTERVENTIONS Rituximab infusions were administered on study days 1 and 15 at doses of either 500 mg or 1000 mg. Initial responders with recurrent inflammation after week 24 were permitted reinfusion with an additional cycle of 2 open-label 1000-mg rituximab infusions. MAIN OUTCOMES AND MEASURES The primary outcomes were reduction of inflammation measured with a validated orbital disease grading scale and corticosteroid dose reduction by at least 50%. The secondary outcomes were visual acuity, reduction in pain, and participantand physician-reported global health assessment. RESULTS Of 10 enrolled patients, 7 demonstrated improvement on the orbital disease grading scale at the 24-week end point with rituximab therapy. Of these 7 individuals, 4 were receiving corticosteroids at study inception and all achieved successful dose reduction. For the secondary outcome measures in the 10 participants, 7 patients and 8 patients improved in self-rated and physician global health scores, respectively, and 7 patients had reduction in pain by 25% or more at 24 weeks. Four patients who were positive responders at the week 24 end point experienced breakthrough inflammation after week 24 and received reinfusions between 24 and 48 weeks. Vision remained stable in all participants. Three of 10 patients had short-term objective or subjective worsening 2 to 8 weeks after receiving rituximab infusions, which was averted in subsequent patients with oral corticosteroids administered during the infusion and did not affect the eventual positive treatment outcome. No significant differences with regard to efficacy, toxicity, or likelihood of retreatment were noted between the dosing arms. CONCLUSIONS AND RELEVANCE Rituximab was safe and effective in 7 of 10 patients with noninfectious orbital disease, although 4 required reinfusion with rituximab to maintain control of orbital inflammation. Substantial toxicity was not noted. Rituximab should be considered in the treatment of refractory orbital inflammation. C1 [Suhler, Eric B.] Portland VA Med Ctr, Portland, OR USA. [Suhler, Eric B.; Lim, Lyndell L.; Beardsley, Robert M.; Giles, Tracy R.; Pasadhilka, Sirichai; Lee, Shelly T.; Saint Sardos, Alexandre de; Butler, Nicholas J.; Smith, Justine R.; Rosenbaum, James T.] Oregon Hlth & Sci Univ, Dept Ophthalmol, Casey Eye Inst, Portland, OR 97239 USA. [Suhler, Eric B.] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA. [Suhler, Eric B.; Lim, Lyndell L.] Univ Melbourne, Dept Ophthalmol, Ctr Eye Res Australia, Melbourne, Vic, Australia. [Lim, Lyndell L.] Royal Victorian Eye & Ear Hosp, Dept Ophthalmol, Melbourne, Vic 3002, Australia. [Smith, Justine R.; Rosenbaum, James T.] Oregon Hlth & Sci Univ, Dept Cell Biol, Portland, OR 97201 USA. [Smith, Justine R.] Flinders Univ S Australia, Adelaide, SA 5001, Australia. [Rosenbaum, James T.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA. [Rosenbaum, James T.] Devers Eye Inst, Dept Ophthalmol, Portland, OR USA. RP Suhler, EB (reprint author), Oregon Hlth & Sci Univ, Dept Ophthalmol, Casey Eye Inst, 3375 SW Terwilliger Blvd, Portland, OR 97239 USA. EM suhlere@ohsu.edu OI Lim, Lyndell/0000-0003-2491-685X FU Genentech, San Francisco, California; Department of Veterans' Affairs; Research to Prevent Blindness (unrestricted grant to Casey Eye Institute, Senior Scholar Award to Dr Rosenbaum); Rosenfeld Family Trust; William and Mary Bauman Foundation FX Study expenses and drug were provided by Genentech, San Francisco, California. Additional research support was provided by the Department of Veterans' Affairs (Dr Suhler), Research to Prevent Blindness (unrestricted grant to Casey Eye Institute, Senior Scholar Award to Dr Rosenbaum), the Rosenfeld Family Trust (Dr Rosenbaum), and the William and Mary Bauman Foundation. NR 32 TC 10 Z9 10 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6165 EI 2168-6173 J9 JAMA OPHTHALMOL JI JAMA Ophthalmol. PD MAY PY 2014 VL 132 IS 5 BP 572 EP 578 DI 10.1001/jamaophthalmol.2013.8179 PG 7 WC Ophthalmology SC Ophthalmology GA AJ7QW UT WOS:000337892500009 PM 24652467 ER PT J AU Sanders, DS Read-Brown, S Tu, DC Lambert, WE Choi, D Almario, BM Yackel, TR Brown, AS Chiang, MF AF Sanders, David S. Read-Brown, Sarah Tu, Daniel C. Lambert, William E. Choi, Dongseok Almario, Bella M. Yackel, Thomas R. Brown, Anna S. Chiang, Michael F. TI Impact of an Electronic Health Record Operating Room Management System in Ophthalmology on Documentation Time, Surgical Volume, and Staffing SO JAMA OPHTHALMOLOGY LA English DT Article ID MEDICAL-RECORDS; INFORMATION-TECHNOLOGY; AMERICAN-ACADEMY; MEANINGFUL USE; PRIMARY-CARE; PHYSICIANS; EFFICIENCY; ADOPTION; COSTS; PAPER AB IMPORTANCE Although electronic health record (EHR) systems have potential benefits, such as improved safety and quality of care, most ophthalmology practices in the United States have not adopted these systems. Concerns persist regarding potential negative impacts on clinical workflow. In particular, the impact of EHR operating room (OR) management systems on clinical efficiency in the ophthalmic surgery setting is unknown. OBJECTIVE To determine the impact of an EHR OR management system on intraoperative nursing documentation time, surgical volume, and staffing requirements. DESIGN. SETTING, AND PARTICIPANTS For documentation time and circulating nurses per procedure, a prospective cohort design was used between January 10, 2012, and January 10, 2013. For surgical volume and overall staffing requirements, a case series design was used between January 29, 2011, and January 28, 2013. This study involved ophthalmic OR nurses (n = 13) and surgeons (n = 25) at an academic medical center. EXPOSURES Electronic health record OR management system implementation. MAIN OUTCOMES AND MEASURES (1) Documentation time (percentage of operating time documenting [POTD], absolute documentation time in minutes), (2) surgical volume (procedures/time), and (3) staffing requirements (full-time equivalents, circulating nurses/procedure). Outcomes were measured during a baseline period when paper documentation was used and during the early (first 3 months) and late (4-12 months) periods after EHR implementation. RESULTS There was a worsening in total POTD in the early EHR period (83%) vs paper baseline (41%) (P <.001). This improved to baseline levels by the late EHR period (46%, P =.28), although POTD in the cataract group remained worse than at baseline (64%, P <.001). There was a worsening in absolute mean documentation time in the early EHR period (16.7 minutes) vs paper baseline (7.5 minutes) (P <.001). This improved in the late EHR period (9.2 minutes) but remained worse than in the paper baseline (P <.001). While cataract procedures required more circulating nurses in the early EHR (mean, 1.9 nurses/procedure) and late EHR (mean, 1.5 nurses/procedure) periods than in the paper baseline (mean, 1.0 nurses/procedure) (P <.001), overall staffing requirements and surgical volume were not significantly different between the periods. CONCLUSIONS AND RELEVANCE Electronic health record OR management system implementation was associated with worsening of intraoperative nursing documentation time especially in shorter procedures. However, it is possible to implement an EHR OR management system without serious negative impacts on surgical volume and staffing requirements. C1 [Sanders, David S.; Read-Brown, Sarah; Tu, Daniel C.; Almario, Bella M.; Brown, Anna S.; Chiang, Michael F.] Oregon Hlth & Sci Univ, Casey Eye Inst, Dept Ophthalmol, Portland, OR 97239 USA. [Tu, Daniel C.] Portland VA Med Ctr, Operat Care Div, Portland, OR USA. [Lambert, William E.; Choi, Dongseok] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA. [Yackel, Thomas R.; Chiang, Michael F.] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97239 USA. RP Chiang, MF (reprint author), Oregon Hlth & Sci Univ, 3375 SW Terwilliger Blvd, Portland, OR 97239 USA. EM chiangm@ohsu.edu OI Read-Brown, Sarah/0000-0002-6526-2939 FU Research to Prevent Blindness (New York, New York); National Institutes of Health [EY10572] FX This work was supported by unrestricted departmental funding from Research to Prevent Blindness (New York, New York) (Mr Sanders, Mss Read-Brown and Brown, and Drs Tu and Chiang). Dr Choi is supported by National Institutes of Health grant EY10572. NR 33 TC 6 Z9 6 U1 5 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6165 EI 2168-6173 J9 JAMA OPHTHALMOL JI JAMA Ophthalmol. PD MAY PY 2014 VL 132 IS 5 BP 586 EP 592 DI 10.1001/jamaophthalmol.2013.8196 PG 7 WC Ophthalmology SC Ophthalmology GA AJ7QW UT WOS:000337892500011 PM 24676217 ER PT J AU Dingle, TC Clarridge, JE AF Dingle, Tanis C. Clarridge, Jill E., III TI Clinical Significance and Characterization of Haemophilus influenzae Type b Genogroup Isolates from Urine Samples in an Adult Male Population SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HEMOPHILUS-INFLUENZAE; TRACT INFECTIONS; PARAINFLUENZAE; CHILDREN; MEN AB The occurrence and significance of Haemophilus spp. isolated from the genitourinary tract are not well known. Herein, we describe the clinical significance and characteristics of Haemophilus influenzae type b genogroup strains isolated from genitourinary tract specimens from an adult male veteran patient population and, in particular, their associations with prostatitis and epididymitis. C1 [Dingle, Tanis C.; Clarridge, Jill E., III] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. [Clarridge, Jill E., III] Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. RP Clarridge, JE (reprint author), Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. EM jill.clarridge@va.gov NR 19 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2014 VL 52 IS 5 BP 1745 EP 1748 DI 10.1128/JCM.00506-14 PG 4 WC Microbiology SC Microbiology GA AJ7XV UT WOS:000337915700069 PM 24599984 ER PT J AU Alzhanova, D Hammarlund, E Reed, J Meermeier, E Rawlings, S Ray, CA Edwards, DM Bimber, B Legasse, A Planer, S Sprague, J Axthelm, MK Pickup, DJ Lewinsohn, DM Gold, MC Wong, SW Sacha, JB Slifka, MK Fruh, K AF Alzhanova, Dina Hammarlund, Erika Reed, Jason Meermeier, Erin Rawlings, Stephanie Ray, Caroline A. Edwards, David M. Bimber, Ben Legasse, Alfred Planer, Shannon Sprague, Jerald Axthelm, Michael K. Pickup, David J. Lewinsohn, David M. Gold, Marielle C. Wong, Scott W. Sacha, Jonah B. Slifka, Mark K. Frueh, Klaus TI T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence SO PLOS PATHOGENS LA English DT Article ID MONKEYPOX VIRUS; COWPOX VIRUS; CONGO BASIN; CLASS-I; IMMUNODEFICIENCY VIRUS; PROTECTIVE IMMUNITY; NONHUMAN PRIMATE; AFRICAN STRAINS; DOWN-REGULATION; WEST-AFRICAN AB Infections with monkeypox, cowpox and weaponized variola virus remain a threat to the increasingly unvaccinated human population, but little is known about their mechanisms of virulence and immune evasion. We now demonstrate that B22 proteins, encoded by the largest genes of these viruses, render human T cells unresponsive to stimulation of the T cell receptor by MHC-dependent antigen presentation or by MHC-independent stimulation. In contrast, stimuli that bypass TCR-signaling are not inhibited. In a non-human primate model of monkeypox, virus lacking the B22R homologue (MPXV Delta 197) caused only mild disease with lower viremia and cutaneous pox lesions compared to wild type MPXV which caused high viremia, morbidity and mortality. Since MPXV Delta 197-infected animals displayed accelerated T cell responses and less T cell dysregulation than MPXV US2003, we conclude that B22 family proteins cause viral virulence by suppressing T cell control of viral dissemination. C1 [Alzhanova, Dina; Reed, Jason; Rawlings, Stephanie; Edwards, David M.; Sprague, Jerald; Axthelm, Michael K.; Wong, Scott W.; Sacha, Jonah B.; Frueh, Klaus] Oregon Natl Primate Res Ctr, Vaccine & Gene Therapy Inst, Portland, OR 97239 USA. [Hammarlund, Erika; Slifka, Mark K.] Oregon Natl Primate Res Ctr, Div Neurosci, Portland, OR USA. [Meermeier, Erin; Lewinsohn, David M.; Gold, Marielle C.] Oregon Hlth & Sci Univ, Dept Pulm & Crit Care Med, Portland, OR 97201 USA. [Meermeier, Erin; Lewinsohn, David M.; Gold, Marielle C.] Portland VA Med Ctr, Portland, OR USA. [Ray, Caroline A.; Pickup, David J.] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC USA. [Bimber, Ben; Legasse, Alfred; Planer, Shannon; Axthelm, Michael K.; Wong, Scott W.; Sacha, Jonah B.; Frueh, Klaus] Oregon Natl Primate Res Ctr, Div Pathobiol & Immunol, Portland, OR USA. RP Alzhanova, D (reprint author), Oregon Natl Primate Res Ctr, Vaccine & Gene Therapy Inst, Portland, OR 97239 USA. EM fruehk@ohsu.edu RI Lewinsohn, David/I-4936-2013 OI Lewinsohn, David/0000-0001-9906-9494; Gold, Marielle/0000-0003-2505-3291; Meermeier, Erin/0000-0002-9709-7624 FU National Institute of Health [U19AI109948]; National Center for Research Resources [P51OD011092]; Office of Research Infrastructure Programs of the National Institutes of Health FX This work was funded by grants U19AI109948 from the National Institute of Health and P51OD011092 from the National Center for Research Resources and the Office of Research Infrastructure Programs of the National Institutes of Health to KF and MKS and supported with resources and the use of facilities at the Portland VA Medical Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 6 Z9 6 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD MAY PY 2014 VL 10 IS 5 AR e1004123 DI 10.1371/journal.ppat.1004123 PG 19 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AJ5NX UT WOS:000337732300034 PM 24832205 ER PT J AU Park, YD Shin, S Panepinto, J Ramos, J Qiu, J Frases, S Albuquerque, P Cordero, RJB Zhang, NN Himmelreich, U Beenhouwer, D Bennett, JE Casadevall, A Williamson, PR AF Park, Yoon-Dong Shin, Soowan Panepinto, John Ramos, Jeanie Qiu, Jin Frases, Susana Albuquerque, Patricia Cordero, Radames J. B. Zhang, Nannan Himmelreich, Uwe Beenhouwer, David Bennett, John E. Casadevall, Arturo Williamson, Peter R. TI A Role for LHC1 in Higher Order Structure and Complement Binding of the Cryptococcus neoformans Capsule SO PLOS PATHOGENS LA English DT Article ID POLYSACCHARIDE CAPSULE; MONOCLONAL-ANTIBODIES; FUSARIUM-OXYSPORUM; VIRULENCE FACTOR; LACCASE; CELL; ACTIVATION; COMPONENTS; INFECTION; STRAINS AB Polysaccharide capsules are important virulence factors for many microbial pathogens including the opportunistic fungus Cryptococcus neoformans. In the present study, we demonstrate an unusual role for a secreted lactonohydrolase of C. neoformans, LHC1 in capsular higher order structure. Analysis of extracted capsular polysaccharide from wild-type and lhc1 (Delta) over bar strains by dynamic and static light scattering suggested a role for the LHC1 locus in altering the capsular polysaccharide, both reducing dimensions and altering its branching, density and solvation. These changes in the capsular structure resulted in LHC1-dependent alterations of antibody binding patterns, reductions in human and mouse complement binding and phagocytosis by the macrophage-like cell line J774, as well as increased virulence in mice. These findings identify a unique molecular mechanism for tertiary structural changes in a microbial capsule, facilitating immune evasion and virulence of a fungal pathogen. C1 [Park, Yoon-Dong; Qiu, Jin; Zhang, Nannan; Bennett, John E.; Williamson, Peter R.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. [Shin, Soowan; Ramos, Jeanie; Williamson, Peter R.] Univ Illinois, Dept Med, Coll Med, Infect Dis Sect, Chicago, IL USA. [Panepinto, John] SUNY Buffalo, Dept Microbiol & Immunol, Buffalo, NY 14260 USA. [Frases, Susana; Albuquerque, Patricia; Cordero, Radames J. B.; Casadevall, Arturo] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Frases, Susana; Albuquerque, Patricia; Cordero, Radames J. B.; Casadevall, Arturo] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Div Infect Dis, Bronx, NY 10467 USA. [Frases, Susana] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Ultraestrutura Cellular Hertha Meyer, BR-21941 Rio De Janeiro, Brazil. [Himmelreich, Uwe] Katholieke Univ Leuven, Div Radiol, Dept Med Diagnost Sci, Biomed NMR Unit, Leuven, Belgium. [Beenhouwer, David] Vet Affairs Greater Los Angeles Healthcare Syst, Div Infect Dis, Los Angeles, CA USA. [Beenhouwer, David] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. RP Park, YD (reprint author), NIAID, Lab Clin Infect Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM williamsonpr@mail.nih.gov RI Albuquerque, Patricia/H-1403-2011 OI Cordero, Radames JB/0000-0002-3026-7094 FU United States Public Health Service [NIH-AI45995, AI49371, AI007506, AI033142, AI47087, HL059842-3, A1033774, A1052733, AI033142.]; Flemish government [FWO G.0804.11]; KUL [PF10/017]; CAPES-Brazil; NIH, NIAID FX This work was supported, in part, by United States Public Health Service Grants NIH-AI45995, AI49371, AI007506, AI033142, AI47087, HL059842-3, A1033774, A1052733, and AI033142. Flemish governmental funding FWO G.0804.11 and KUL funding PF10/017 and a CAPES-Brazil/Fulbright scholarship (PA). This research was also supported, in part, by the Intramural Research Program of the NIH, NIAID. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 6 Z9 6 U1 1 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD MAY PY 2014 VL 10 IS 5 AR e1004037 DI 10.1371/journal.ppat.1004037 PG 13 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AJ5NX UT WOS:000337732300003 PM 24789368 ER PT J AU Turner, AP Sloan, AP Kivlahan, DR Haselkorn, JK AF Turner, Aaron P. Sloan, Alicia P. Kivlahan, Daniel R. Haselkorn, Jodie K. TI Telephone Counseling and Home Telehealth Monitoring to Improve Medication Adherence: Results of a Pilot Trial Among Individuals With Multiple Sclerosis SO REHABILITATION PSYCHOLOGY LA English DT Article DE multiple sclerosis; medication adherence; motivational interviewing; self-management; telehealth ID DISEASE-MODIFYING THERAPIES; RANDOMIZED CONTROLLED-TRIAL; TRAUMATIC BRAIN-INJURY; QUALITY-OF-LIFE; INJECTION ANXIETY; CHRONIC ILLNESS; PRIMARY-CARE; SELF-INJECT; ALCOHOL-DEPENDENCE; DEPRESSION AB Objective: To evaluate the impact upon medication adherence of brief telephone-based counseling using principles of motivational interviewing and telehealth home monitoring. Design: Randomized controlled pilot trial of 19 veterans with multiple sclerosis (MS) currently prescribed disease modifying therapy (DMT) who endorsed missing doses. Follow-up was conducted at 1, 3, and 6 months. Results: Participants in the intervention condition reported better adherence relative to controls at 6-month follow-up [M (SD) = 1.3 (2.1) vs. 8.2 (12.3) past month missed doses]. All participants in the intervention condition completed all 3 telephone counseling sessions and 90% or greater rated the program as highly successful. Conclusion: Brief telephone counseling represents a promising mechanism for improving medication adherence. The primary components, motivational interviewing and home telehealth monitoring, provided complementary mechanisms for initiating and sustaining behavior change over time. The intervention was well tolerated and provided an opportunity to extend access and reduce barriers to care by bringing it into the homes of participants. C1 [Turner, Aaron P.; Sloan, Alicia P.; Kivlahan, Daniel R.; Haselkorn, Jodie K.] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. [Turner, Aaron P.; Sloan, Alicia P.; Haselkorn, Jodie K.] VA MS Ctr Excellence West, Seattle, WA USA. [Turner, Aaron P.; Kivlahan, Daniel R.] VA Ctr Excellence Subst Abuse Treatment & Educ, Seattle, WA USA. [Turner, Aaron P.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Kivlahan, Daniel R.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Haselkorn, Jodie K.] Univ Washington, VA Puget Sound Hlth Care Syst, VA MS Ctr Excellence West, Dept Rehabil Med, Seattle, WA 98195 USA. [Haselkorn, Jodie K.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. RP Turner, AP (reprint author), VA Puget Sound Hlth Care Syst, Rehabil Care Serv, S-117-RCS,1660 S Columbian Way, Seattle, WA 98108 USA. EM Aaron.Turner@med.va.gov OI sloan, alicia/0000-0003-4891-3266; Turner, Aaron/0000-0001-6897-8003 NR 75 TC 4 Z9 4 U1 4 U2 11 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 0090-5550 EI 1939-1544 J9 REHABIL PSYCHOL JI Rehabil. Psychol. PD MAY PY 2014 VL 59 IS 2 BP 136 EP 146 DI 10.1037/a0036322 PG 11 WC Psychology, Clinical; Rehabilitation SC Psychology; Rehabilitation GA AJ7SQ UT WOS:000337897800003 PM 24708232 ER PT J AU Bambara, JK Turner, AP Williams, RM Haselkorn, JK AF Bambara, Jennifer K. Turner, Aaron P. Williams, Rhonda M. Haselkorn, Jodie K. TI Social Support and Depressive Symptoms Among Caregivers of Veterans With Multiple Sclerosis SO REHABILITATION PSYCHOLOGY LA English DT Article DE multiple sclerosis; caregiver; social support; depression; veterans ID DISEASE-MODIFYING THERAPIES; QUALITY-OF-LIFE; FAMILY CAREGIVERS; HEALTH; IMPAIRMENT; ADHERENCE; VALIDATION; DISABILITY; ADJUSTMENT; VALIDITY AB Purpose/Objective: The primary aim of this study was to examine the relationship between perceived social support and depressive symptoms among family caregivers of veterans with multiple sclerosis (MS). A secondary aim of this study was to examine the relationship between caregiver perceived social support and caregiver demographic variables, veteran health-related variables, and caregiver depressive symptoms. Research Method/Design: As part of a larger study, 42 family caregivers of veterans with MS completed questionnaires by telephone. Hierarchical regression was used to examine the relationship between caregiver depressive symptoms and perceived social support. Results: Greater MS disease severity and poorer overall veteran health were associated with higher levels of depressive symptoms among caregivers. Caregiver perceived social support was associated with depressive symptoms after controlling for veterans' MS disease severity and overall physical health. Conclusions/Implications: Psychosocial interventions aimed at enhancing social support among caregivers of veterans with MS in multiple life domains, such as work, finances, housing, social life, marriage, and family, may be important for family caregiver mood management, particularly as MS disease severity increases. C1 [Bambara, Jennifer K.; Turner, Aaron P.; Williams, Rhonda M.; Haselkorn, Jodie K.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Turner, Aaron P.; Haselkorn, Jodie K.] VA MS Ctr Excellence West, Seattle, WA USA. [Turner, Aaron P.; Williams, Rhonda M.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Haselkorn, Jodie K.] Univ Washington, Dept Rehabil Med & Epidemiol, Seattle, WA 98195 USA. RP Bambara, JK (reprint author), Vet Adm Puget Sound Hlth Care Syst, Seattle Div, Rehabil Care Serv, S-117-RCS,1660 S Columbian Way, Seattle, WA 98108 USA. EM jennifer.bambara@va.gov OI Turner, Aaron/0000-0001-6897-8003 NR 29 TC 1 Z9 1 U1 2 U2 10 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 0090-5550 EI 1939-1544 J9 REHABIL PSYCHOL JI Rehabil. Psychol. PD MAY PY 2014 VL 59 IS 2 BP 230 EP 235 DI 10.1037/a0036312 PG 6 WC Psychology, Clinical; Rehabilitation SC Psychology; Rehabilitation GA AJ7SQ UT WOS:000337897800014 PM 24730574 ER PT J AU Bachhuber, MA Southern, WN Cunningham, CO AF Bachhuber, Marcus A. Southern, William N. Cunningham, Chinazo O. TI Profiting and Providing Less Care Comprehensive Services at For-Profit, Nonprofit, and Public Opioid Treatment Programs in the United States SO MEDICAL CARE LA English DT Article DE drug abuse; mental health; social services; infectious disease; health care organization ID SUBSTANCE-ABUSE TREATMENT; INJECTION-DRUG USERS; MAINTENANCE TREATMENT PROGRAMS; METHADONE-MAINTAINED PATIENTS; PSYCHIATRIC COMORBIDITY; HEPATITIS-C; PSYCHOSOCIAL SERVICES; HIV-INFECTION; MEDICAL-CARE; PREVENTION AB Background:Opioid use disorders are frequently associated with medical and psychiatric comorbidities (eg, HIV infection and depression), as well as social problems (eg, lack of health insurance). Comprehensive services addressing these conditions improve outcomes.Objective:To compare the proportion of for-profit, nonprofit, and public opioid treatment programs offering comprehensive services, which are not mandated by government regulations.Design, Setting, and Participants:Cross-sectional analysis of opioid treatment programs offering outpatient care in the United States (n=1036).Main Outcome Measure:Self-reported offering of communicable disease (HIV, sexually transmitted infections, and viral hepatitis) testing, psychiatric services (screening, assessment and diagnostic evaluation, and pharmacotherapy), and social services support (assistance in applying for programs such as Medicaid). Mixed-effects logistic regression models were developed to adjust for several county-level factors.Results:Of opioid treatment programs, 58.0% were for profit, 33.5% were nonprofit, and 8.5% were public. Nonprofit programs were more likely than for-profit programs to offer testing for all communicable diseases [adjusted odds ratios (AOR), 1.7; 95% confidence interval (CI), 1.2, 2.5], all psychiatric services (AOR, 8.0; 95% CI, 4.9, 13.1), and social services support (AOR, 3.3; 95% CI, 2.3, 4.8). Public programs were also more likely than for-profit programs to offer communicable disease testing (AOR, 6.4; 95% CI, 3.5, 11.7), all psychiatric services (AOR, 25.8; 95% CI, 12.6, 52.5), and social services support (AOR, 2.4; 95% CI, 1.4, 4.3).Conclusions:For-profit programs were significantly less likely than nonprofit and public programs to offer comprehensive services. Interventions to increase the offering of comprehensive services are needed, particularly among for-profit programs. C1 [Bachhuber, Marcus A.] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. [Bachhuber, Marcus A.] Robert Wood Johnson Fdn, Clin Scholars Program, Philadelphia, PA USA. [Bachhuber, Marcus A.] Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA. [Southern, William N.] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Div Hosp Med, Bronx, NY 10467 USA. [Cunningham, Chinazo O.] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Div Gen Internal Med, Bronx, NY 10467 USA. RP Bachhuber, MA (reprint author), 1303-A Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM marcus.bachhuber@gmail.com OI Bachhuber, Marcus/0000-0002-5610-8382 FU NIH [R34DA031066, R01DA032110, R25DA023021]; Center for AIDS Research at the Albert Einstein College of Medicine; Montefiore Medical Center [NIH AI-51519] FX Supported by NIH R34DA031066, R01DA032110, R25DA023021, and the Center for AIDS Research at the Albert Einstein College of Medicine and Montefiore Medical Center (NIH AI-51519). NR 52 TC 0 Z9 0 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD MAY PY 2014 VL 52 IS 5 BP 428 EP 434 DI 10.1097/MLR.0000000000000121 PG 7 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AJ0BB UT WOS:000337312800009 PM 24638120 ER PT J AU Gabrielian, S Yuan, AH Andersen, RM Rubenstein, LV Gelberg, L AF Gabrielian, Sonya Yuan, Anita H. Andersen, Ronald M. Rubenstein, Lisa V. Gelberg, Lillian TI VA Health Service Utilization for Homeless and Low-income Veterans A Spotlight on the VA Supportive Housing (VASH) Program in Greater Los Angeles SO MEDICAL CARE LA English DT Article DE veterans; homelessness; supportive housing ID ANDERSEN BEHAVIORAL-MODEL; MENTAL-ILLNESS; MEDICAL-CARE; VULNERABLE POPULATIONS; EMERGENCY-DEPARTMENT; PUBLIC-HEALTH; ACCESS; WOMEN; 1ST; INDIVIDUALS AB Background:The US Department of Housing and Urban Development (HUD)-VA Supportive Housing (VASH) programthe VA's Housing First effortis central to efforts to end Veteran homelessness. Yet, little is known about health care utilization patterns associated with achieving HUD-VASH housing.Objectives:We compare health service utilization at the VA Greater Los Angeles among: (1) formerly homeless Veterans housed through HUD-VASH (HUD-VASH Veterans); (2) currently homeless Veterans; (3) housed, low-income Veterans not in HUD-VASH; and (4) housed, not low-income Veterans.Research Design:We performed a secondary database analysis of Veterans (n=62,459) who received VA Greater Los Angeles care between October 1, 2010 and September 30, 2011. We described medical/surgical and mental health utilization [inpatient, outpatient, and emergency department (ED)]. We controlled for demographics, need, and primary care use in regression analyses of utilization data by housing and income status.Results:HUD-VASH Veterans had more inpatient, outpatient, and ED use than currently homeless Veterans. Adjusting for demographics and need, HUD-VASH Veterans and the low-income housed Veterans had similar likelihoods of medical/surgical inpatient and outpatient utilization, compared with the housed, not low-income group. Adjusting first for demographics and need (model 1), then also for primary care use (model 2), HUD-VASH Veterans had the greatest decrease in incident rates of specialty medical/surgical, mental health, and ED care from models 1 to 2, becoming similar to the currently homeless, compared with the housed, not low-income group.Conclusions:Our findings suggest that currently homeless Veterans underuse health care relative to housed Veterans. HUD-VASH may address this disparity by providing housing and linkages to primary care. C1 [Gabrielian, Sonya] VA Greater Los Angeles, Dept Psychiat, Los Angeles, CA USA. [Gabrielian, Sonya] VA Greater Los Angeles, Mental Illness Res Educ & Clin Ctr, Los Angeles, CA USA. [Gabrielian, Sonya; Yuan, Anita H.; Andersen, Ronald M.; Rubenstein, Lisa V.; Gelberg, Lillian] VA Greater Los Angeles, Hlth Serv Res & Dev Ctr Excellence Study Healthca, Los Angeles, CA USA. [Gabrielian, Sonya] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Yuan, Anita H.] Univ Calif Los Angeles, Vet Emergency Management Evaluat Ctr, Los Angeles, CA USA. [Andersen, Ronald M.; Gelberg, Lillian] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA. [Rubenstein, Lisa V.] VA Greater Los Angeles, Dept Med, Los Angeles, CA USA. [Rubenstein, Lisa V.] RAND Corp, Santa Monica, CA USA. [Gelberg, Lillian] Univ Calif Los Angeles, Dept Family Med, Los Angeles, CA USA. RP Gabrielian, S (reprint author), WLA, VA Greater Los Angeles, 11301 Wilshire Blvd,Bldg 210A, Los Angeles, CA 90073 USA. EM sonya.gabrielian@va.gov FU Locally Initiated Project Grant from the Health Services Research & Development Center of Excellence for the Study of Healthcare Provider Behavior at the VA Greater Los Angeles [LIP 65-029]; VA Office of Patient Care Services; Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs; Veterans Emergency Management Evaluation Center (VEMEC); Office of Academic Affiliations, Advanced Fellowship Program in Health Services Research, Department of Veterans Affairs [TPP 65-013]; NIDA [DA 022445]; UCLA/Drew Project EXPORT, National Center on Minority Health and Health Disparities [P20MD000148/P20MD000182]; VAIL-PCC [XVA 650-18] FX Supported by a Locally Initiated Project Grant from the Health Services Research & Development Center of Excellence for the Study of Healthcare Provider Behavior at the VA Greater Los Angeles (LIP 65-029). In part, this work was undertaken through the Veterans Administration's PACT Demonstration Laboratory initiative, supporting and evaluating VA's transition to a patient-centered medical home. Funding for the PACT Demonstration Laboratory initiative is provided by the VA Office of Patient Care Services. S. G. was supported in part by the Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs. A.H.Y. was supported by the Veterans Emergency Management Evaluation Center (VEMEC) and the Office of Academic Affiliations, Advanced Fellowship Program in Health Services Research, Department of Veterans Affairs (TPP 65-013). L. G. and R. M. A. were supported in part by NIDA DA 022445. R. M. A. received additional support from the UCLA/Drew Project EXPORT, National Center on Minority Health and Health Disparities, P20MD000148/P20MD000182. L. R. was supported in part by VAIL-PCC (XVA 650-18). NR 48 TC 4 Z9 4 U1 3 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD MAY PY 2014 VL 52 IS 5 BP 454 EP 461 DI 10.1097/MLR.0000000000000112 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AJ0BB UT WOS:000337312800014 PM 24714583 ER PT J AU Fidler, R Hirsch, J Stechert, M Johnson, M AF Fidler, Richard Hirsch, Jan Stechert, Martin Johnson, Meshell TI Three modes of cardiac compressions in a single patient: A comparison of usual manual compressions, automated compressions, and open cardiac massage SO RESUSCITATION LA English DT Letter ID CARDIOPULMONARY-RESUSCITATION; ARREST C1 [Fidler, Richard; Hirsch, Jan; Stechert, Martin] Univ Calif San Francisco, Dept Anesthesia, San Francisco VA Med Ctr, San Francisco, CA 94143 USA. [Johnson, Meshell] Univ Calif San Francisco, Dept Med, San Francisco VA Med Ctr, San Francisco, CA USA. RP Fidler, R (reprint author), San Francisco VA Med Ctr, 4150 Clement St,Anesthesiol 129, San Francisco, CA 94121 USA. EM richard.fidler@ucsf.edu OI Fidler, Richard/0000-0003-4358-7887 NR 5 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD MAY PY 2014 VL 85 IS 5 BP E75 EP E76 DI 10.1016/j.resuscitation.2014.01.010 PG 2 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA AJ0GX UT WOS:000337329500005 PM 24447422 ER PT J AU Lai, YY Dilidaer, D Chen, B Xu, G Shi, JB Lee, RJ Cohen, NA AF Lai, Yinyan Dilidaer, D. Chen, Bei Xu, Geng Shi, Jianbo Lee, Robert J. Cohen, Noam A. TI In vitro studies of a distillate of rectified essential oils on sinonasal components of mucociliary clearance SO AMERICAN JOURNAL OF RHINOLOGY & ALLERGY LA English DT Article ID CILIARY BEAT FREQUENCY; UPPER RESPIRATORY-INFECTION; CHRONIC RHINOSINUSITIS; FLUID SECRETION; TRANSPORT; CILIOGENESIS; T2R38 AB Background: Herbal remedies predate written history and continue to be used frequently for many common ailments. The essential oil mixture standardized is a phytopharmaceutical with a distillate of a mixture of rectified essential oils of eucalyptus, sweet orange, myrtle, and lemon as active ingredients used to treat respiratory diseases such as bronchitis and rhinosinusitis. We evaluated the pharmacologic effects of a distillate of rectified essential oils standardized on primary human upper respiratory epithelial cultures specifically addressing electrolyte transport, cilia beat frequency (CBF), airway surface liquid (ASL) hydration, and mucus transport velocity. Methods: Well-differentiated primary human sinonasal epithelial cultures grown at an air-liquid interface were treated on the apical or basolateral surface with varying concentrations of a distillate of rectified essential oils standardized. Changes in CBF were determined using the Sissons-Ammons Video Analysis system while changes in chloride flux were determined using the fluorescent dye 6-methoxy-N-(3-sulfopropyl) quinolinium. ASL hydration was quantified using Texas red dextran and mucociliary transport velocity was measured using fluorescent microspheres and time lapse photography. Results: When applied to the basolateral surface, a distillate of rectified essential oils standardized activated chloride efflux and ciliary beat in a dose-dependent fashion, increasing ASL height and accelerating mucociliary transport velocity. The ancillary apical application of a distillate of rectified essential oils standardized had minimal effects on the CBF. Conclusion: Basolateral application of a distillate of rectified essential oils standardized stimulates both chloride efflux and cilia beat frequency resulting in a synergistic effect dramatically augmenting mucociliary transport velocity. These in vitro data support the clinical efficacy of this phytopharmaceutical in respiratory inflammatory disorders. C1 [Lai, Yinyan; Dilidaer, D.; Chen, Bei; Lee, Robert J.] Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA. [Lai, Yinyan; Dilidaer, D.; Xu, Geng; Shi, Jianbo; Cohen, Noam A.] Sun Yat Sen Univ, Affiliated Hosp 1, Otorhinolaryngol Hosp, Guangzhou 510275, Guangdong, Peoples R China. [Cohen, Noam A.] Philadelphia Vet Affairs Med Ctr, Surg Serv, Div Otolaryngol, Philadelphia, PA USA. RP Cohen, NA (reprint author), Univ Penn, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Div Rhinol, 5th Floor Ravdin Bldg,3400 Spruce St, Philadelphia, PA 19104 USA. EM cohenn@uphs.upenn.edu OI Cohen, Noam/0000-0002-9462-3932; Lee, Robert/0000-0001-5826-6686 FU G. Pohl Boskamp, Hohenlockstedt, Germany FX Funded by G. Pohl Boskamp, Hohenlockstedt, Germany NR 20 TC 4 Z9 6 U1 0 U2 9 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1945-8924 EI 1945-8932 J9 AM J RHINOL ALLERGY JI Am. J. Rhinol. Allergy PD MAY-JUN PY 2014 VL 28 IS 3 BP 244 EP 248 DI 10.2500/ajra.2014.28.4036 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AI9QY UT WOS:000337269100016 PM 24980236 ER PT J AU Luxton, DD Pruitt, LD O'Brien, K Stanfill, K Jenkins-Guarnieri, MA Johnson, K Wagner, A Thomas, E Gahm, GA AF Luxton, David D. Pruitt, Larry D. O'Brien, Karen Stanfill, Katherine Jenkins-Guarnieri, Michael A. Johnson, Kristine Wagner, Amy Thomas, Elissa Gahm, Gregory A. TI Design and methodology of a randomized clinical trial of home-based telemental health treatment for US military personnel and veterans with depression SO CONTEMPORARY CLINICAL TRIALS LA English DT Article DE Telemental health; Telehealth; Home-based; Depression; Military; Veterans ID POSTTRAUMATIC-STRESS-DISORDER; BEHAVIORAL ACTIVATION; THERAPY; SCALE; NONINFERIORITY; OUTCOMES; PTSD AB Home-based telemental health (TMH) treatments have the potential to address current and future health needs of military service members, veterans, and their families, especially for those who live in rural or underserved areas. The use of home-based TMH treatments to address the behavioral health care needs of U.S. military healthcare beneficiaries is not presently considered standard of care in the Military Health System. The feasibility, safety, and clinical efficacy of home-based TMH treatments must be established before broad dissemination of home-based treatment programs can be implemented. This paper describes the design, methodology, and protocol of a clinical trial that compares in-office to home-based Behavioral Activation for Depression (BATD) treatment delivered via web-based video technology for service members and veterans with depression. This grant funded three-year randomized clinical trial is being conducted at the National Center for Telehealth and Technology at Joint-base Lewis-McChord and at the Portland VA Medical Center. Best practice recommendations regarding the implementation of in-home telehealth in the military setting as well as the cultural and contextual factors of providing in-home care to active duty and veteran military populations are also discussed. Published by Elsevier Inc. C1 [Luxton, David D.; Pruitt, Larry D.; O'Brien, Karen; Stanfill, Katherine; Jenkins-Guarnieri, Michael A.; Johnson, Kristine; Thomas, Elissa; Gahm, Gregory A.] Natl Ctr Telehealth & Technol, Tacoma, WA USA. [Luxton, David D.; Gahm, Gregory A.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Wagner, Amy] Portland VA Med Ctr, Portland, OR USA. RP Luxton, DD (reprint author), Def Ctr Excellence Psychol Hlth & Traumat Brain I, Natl Ctr Telehealth & Technol T2, 9933 West Hayes St, Tacoma, WA 98431 USA. EM david.d.luxton.civ@mail.mil OI Pruitt, Larry/0000-0001-6925-7830 FU U.S. Army Medical Research & Materiel Command (USAMRMC); Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD [W81XWH-11-2-0118] FX This research grant was awarded and administered by the U.S. Army Medical Research & Materiel Command (USAMRMC) and the Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD (award # W81XWH-11-2-0118). The content of this information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. NR 39 TC 5 Z9 5 U1 0 U2 12 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1551-7144 EI 1559-2030 J9 CONTEMP CLIN TRIALS JI Contemp. Clin. Trials PD MAY PY 2014 VL 38 IS 1 BP 134 EP 144 DI 10.1016/j.cct.2014.04.002 PG 11 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA AI8VA UT WOS:000337203900015 PM 24747488 ER PT J AU Milian, MJ Fone, K Steckler, T Horan, WP AF Milian, Mark J. Fone, Kevin Steckler, Thomas Horan, William P. TI Negative symptoms of schizophrenia: Clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Editorial Material DE Prefrontal cortex; Striatum; Motivation; Social cognition; Social interaction; Oxytocin ID TRANSCRANIAL MAGNETIC STIMULATION; CONDITIONED PLACE PREFERENCE; RANDOMIZED CONTROLLED-TRIALS; SOCIAL-INTERACTION DEFICITS; VENTRAL HIPPOCAMPAL LESION; COGNITIVE-BEHAVIOR THERAPY; AUTISM SPECTRUM DISORDERS; 1ST EPISODE PSYCHOSIS; DEVELOPMENTAL NEUROPSYCHIATRIC DISORDERS; NEURODEVELOPMENTAL RAT MODEL AB Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults at the time of the first psychotic episode of delusions and hallucinations. These positive symptoms can be controlled in most patients by currently-available antipsychotics. Conversely, they are poorly effective against concomitant neurocognitive dysfunction, deficits in social cognition and negative symptoms (NS), which strongly contribute to poor functional outcome. The precise notion of NS has evolved over the past century, with recent studies - underpinned by novel rating methods - suggesting two major sub-domains: "decreased emotional expression", incorporating blunted affect and poverty of speech, and "avolition", which embraces amotivation, asociality and "anhedonia" (inability to anticipate pleasure). Recent studies implicate a dysfunction of frontocortico-temporal networks in the aetiology of NS, together with a disruption of cortico-striatal circuits, though other structures are also involved, like the insular and parietal cortices, amygdala and thalamus. At the cellular level, a disruption of GABAergicglutannatergic balance, dopaminergic signalling and, possibly, oxytocinergic and cannibinoidergic transmission may be involved. Several agents are currently under clinical investigation for the potentially improved control of NS, including oxytocin itself, N-Methyl-D-Aspartate receptor modulators and minocycline. Further, magnetic-electrical "stimulation" strategies to recruit cortical circuits and "cognitive-behavioural-psychosocial" therapies likewise hold promise. To acquire novel insights into the causes and treatment of NS, experimental study is crucial, and opportunities are emerging for improved genetic, pharmacological and developmental modelling, together with more refined readouts related to deficits in reward, sociality and "expression". The present article comprises an integrative overview of the above issues as a platform for this Special Issue of European Neuropsychopharmacology in which five clinical and five preclinical articles treat individual themes in greater detail. This Volume provides, then, a framework for progress in the understanding - and ultimately control - of the debilitating NS of schizophrenia. (c) 2014 Elsevier B.V. and ECNP. C1 [Milian, Mark J.] Inst Rech Servier, F-78290 Paris, France. [Fone, Kevin] Univ Nottingham, Queens Med Ctr, Sch Med, Sch Biomed Sci, Nottingham NG7 2UH, England. [Steckler, Thomas] Janssen Res & Dev, B-2340 Beerse, Belgium. [Horan, William P.] Univ Calif Los Angeles, VA Greater Angeles Healthcare Syst, Los Angeles, CA 90073 USA. RP Milian, MJ (reprint author), Inst Rech Servier, 125 Chemin Ronde, F-78290 Paris, France. EM mark.millan@fr.netgrs.com NR 467 TC 10 Z9 12 U1 7 U2 30 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD MAY PY 2014 VL 24 IS 5 SI SI BP 645 EP 692 DI 10.1016/j.euroneuro.2014.03.008 PG 48 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA AI8YE UT WOS:000337212100001 ER PT J AU Linnemann, AK Baan, M Davis, DB AF Linnemann, Amelia K. Baan, Mieke Davis, Dawn Belt TI Pancreatic beta-Cell Proliferation in Obesity SO ADVANCES IN NUTRITION LA English DT Review ID HEPATOCYTE GROWTH-FACTOR; HIGH-FAT DIET; GLUCAGON-LIKE PEPTIDE-1; DIABETES SUSCEPTIBILITY LOCI; SCALE ASSOCIATION ANALYSIS; INDUCED INSULIN-RESISTANCE; ACTIVATED-RECEPTOR-GAMMA; CYCLIN D2 EXPRESSION; GENE-EXPRESSION; GLUCOSE-INTOLERANCE AB Because obesity rates have increased dramatically over the past 3 decades, type 2 diabetes has become increasingly prevalent as well. Type 2 diabetes is associated with decreased pancreatic beta-cell mass and function, resulting in inadequate insulin production. Conversely, in nondiabetic obesity, an expansion in beta-cell mass occurs to provide sufficient insulin and to prevent hyperglycemia. This expansion is at least in part due to beta-cell proliferation. This review focuses on the mechanisms regulating obesity-induced beta-cell proliferation in humans and mice. Many factors have potential roles in the regulation of obesity-driven beta-cell proliferation, including nutrients, insulin, incretins, hepatocyte growth factor, and recently identified liver-derived secreted factors. Much is still unknown about the regulation of beta-cell replication, especially in humans. The extracellular signals that activate proliferative pathways in obesity, the relative importance of each of these pathways, and the extent of cross-talk between these pathways are important areas of future study. C1 [Linnemann, Amelia K.; Baan, Mieke; Davis, Dawn Belt] Univ Wisconsin, Dept Med, Div Endocrinol, Madison, WI 53706 USA. [Baan, Mieke] Univ Wisconsin, Sch Vet Med, Madison, WI USA. [Davis, Dawn Belt] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. RP Davis, DB (reprint author), Univ Wisconsin, Dept Med, Div Endocrinol, Madison, WI 53706 USA. EM dbd@medicine.wisc.edu FU National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [DK083442]; NIH Ruth L. Kirschstein National Research Service Award Institutional Training Grant from the National Center for Research Resources [T32 RR023916/OD010423] FX D.B.D. is supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK083442 M.B. is supported by the NIH Ruth L. Kirschstein National Research Service Award Institutional Training Grant T32 RR023916/OD010423 from the National Center for Research Resources. The William S. Middleton Memorial Veterans Hospital provided resources and use of facilities. The contents of this manuscript do not necessarily represent the views of the Department of Veterans Affairs or the U.S. Government NR 95 TC 16 Z9 16 U1 0 U2 4 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 2161-8313 EI 2156-5376 J9 ADV NUTR JI Adv. Nutr. PD MAY PY 2014 VL 5 IS 3 BP 278 EP 288 DI 10.3945/an.113.005488 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AI5CV UT WOS:000336883900007 PM 24829474 ER PT J AU Chacon-Heszele, MF Zuo, XF Hellman, NE McKenna, S Choi, SY Huang, LW Tobias, JW Park, KM Lipschutz, JH AF Chacon-Heszele, Maria F. Zuo, Xiaofeng Hellman, Nathan E. McKenna, Sarah Choi, Soo Young Huang, Liwei Tobias, John W. Park, Kwon Moo Lipschutz, Joshua H. TI Novel MAPK-dependent and -independent tubulogenes identified via microarray analysis of 3D-cultured Madin-Darby canine kidney cells SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY LA English DT Article DE mitogen-activated protein kinase; matrix metalloproteinase; development; kidney; tubulogenesis ID HEPATOCYTE GROWTH-FACTOR; IN-VITRO; EPITHELIAL-CELLS; MDCK CELLS; LINE MDCK; ENDOPLASMIC-RETICULUM; EMBRYONIC KIDNEY; GAMMA-CATENIN; MORPHOGENESIS; EXPRESSION AB Cystogenesis and tubulogenesis are basic building blocks for many epithelial organs, including the kidney. Most researchers have used two-dimensional (2D) cell culture to investigate signaling pathways downstream of hepatocyte growth factor (HGF). We hypothesize that three-dimensional (3D) collagen-grown Madin-Darby canine kidney (MDCK) cells, which form cysts and then tubulate in response to HGF, are a much more in vivo-like system for the identification of novel tubulogenes. With the use of a canine microarray containing over 20,000 genes, 2,417 genes were identified as potential tubulogenes that were differentially regulated, exclusively in 3D-grown MDCK cells. Among these, 840 were dependent on MAPK signaling. Importantly, this work shows that many putative tubulogenes, previously identified via microarray analysis of 2D cultures, including by us, do not change in 3D culture and vice versa. The use of a 3D-culture system allowed for the identification of novel MAPK dependent and -independent genes that regulate early renal tubulogenesis in vitro, e. g., matrix metalloproteinase 1 (MMP1). Knockdown of MMP1 led to defects in cystogenesis and tubulogenesis in 3D-grown MDCK cells, most likely due to problems establishing normal polarity. We suggest that data obtained from 2D cultures, even those using MDCK cells treated with HGF, should not be automatically extrapolated to factors important for cystogenesis and tubulogenesis. Instead, 3D culture, which more closely replicates the biological environment and is therefore a more accurate model for identifying tubulogenes, is preferred. Results from the present analysis will be used to build a more accurate model of the signaling pathways that control cystogenesis and tubulogenesis. C1 [Chacon-Heszele, Maria F.; Zuo, Xiaofeng; Hellman, Nathan E.; McKenna, Sarah; Choi, Soo Young; Huang, Liwei; Lipschutz, Joshua H.] Univ Penn, Renal Electrolyte & Hypertens Div, Dept Med, Philadelphia, PA 19104 USA. [Tobias, John W.] Univ Penn, Genom Inst, Bioinformat Core, Philadelphia, PA 19104 USA. [Park, Kwon Moo] Kyungpook Natl Univ, Sch Med, Dept Anat, Taegu 702701, South Korea. [Lipschutz, Joshua H.] Philadelphia Vet Affairs Med Ctr, Dept Med, Philadelphia, PA USA. RP Lipschutz, JH (reprint author), Univ Penn, Renal Electrolyte & Hypertens Div, Rm 405C,Clin Res Bldg, Philadelphia, PA 19104 USA. EM jhlipsch@mail.med.upenn.edu FU VA Merit Award [I01BX000820]; National Institute of Diabetes and Digestive and Kidney Diseases [DK069909, DK047757, DK093625]; NephHope Foundation; Satellite Healthcare (Norman S. Coplon Extramural Research Grant); University of Pennsylvania Translational Medicine Institute (Pilot Grant) FX Support for this work was provided, in part, by grants from the VA Merit Award (I01BX000820 to J. H. Lipschutz), National Institute of Diabetes and Digestive and Kidney Diseases (DK069909 and DK047757 to J. H. Lipschutz and DK093625 to L. Huang), NephHope Foundation (fellowship to M. F. Chacon-Heszele), Satellite Healthcare (Norman S. Coplon Extramural Research Grant to J. H. Lipschutz), and University of Pennsylvania Translational Medicine Institute (Pilot Grant to J. H. Lipschutz). NR 46 TC 4 Z9 4 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1931-857X EI 1522-1466 J9 AM J PHYSIOL-RENAL JI Am. J. Physiol.-Renal Physiol. PD MAY PY 2014 VL 306 IS 9 BP F1047 EP F1058 DI 10.1152/ajprenal.00589.2013 PG 12 WC Physiology; Urology & Nephrology SC Physiology; Urology & Nephrology GA AI4OO UT WOS:000336844900011 PM 24573390 ER PT J AU Kemp, JJ Lickel, JJ Deacon, BJ AF Kemp, Joshua J. Lickel, James J. Deacon, Brett J. TI Effects of a chemical imbalance causal explanation on individuals' perceptions of their depressive symptoms SO BEHAVIOUR RESEARCH AND THERAPY LA English DT Article DE Depression; Chemical imbalance; Stigma; Prognosis; Etiology ID MENTAL-DISORDER; MOOD-REGULATION; STIGMA; EXPECTANCIES AB Although the chemical imbalance theory is the dominant causal explanation of depression in the United States, little is known about the effects of this explanation on depressed individuals. This experiment examined the impact of chemical imbalance test feedback on perceptions of stigma, prognosis, negative mood regulation expectancies, and treatment credibility and expectancy. Participants endorsing a past or current depressive episode received results of a bogus but credible biological test demonstrating their depressive symptoms to be caused, or not caused, by a chemical imbalance in the brain. Results showed that chemical imbalance test feedback failed to reduce self-blame, elicited worse prognostic pessimism and negative mood regulation expectancies, and led participants to view pharmacotherapy as more credible and effective than psychotherapy. The present findings add to a growing literature highlighting the unhelpful and potentially iatrogenic effects of attributing depressive symptoms to a chemical imbalance. Clinical and societal implications of these findings are discussed. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Kemp, Joshua J.; Deacon, Brett J.] Univ Wyoming, Dept Psychol, Laramie, WY 82071 USA. [Lickel, James J.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI 53705 USA. RP Deacon, BJ (reprint author), Univ Wyoming, Dept Psychol, Dept 3415,1000 E Univ Ave, Laramie, WY 82071 USA. EM bdeacon@uwyo.edu NR 30 TC 10 Z9 10 U1 3 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0005-7967 EI 1873-622X J9 BEHAV RES THER JI Behav. Res. Ther. PD MAY PY 2014 VL 56 BP 47 EP 52 DI 10.1016/j.brat.2014.02.009 PG 6 WC Psychology, Clinical SC Psychology GA AI6WJ UT WOS:000337017400007 PM 24657311 ER PT J AU Valente, MAE Voors, AA Damman, K Van Veldhuisen, DJ Massie, BM O'Connor, CM Metra, M Ponikowski, P Teerlink, JR Cotter, G Davison, B Cleland, JGF Givertz, MM Bloomfield, DM Fiuzat, M Dittrich, HC Hillege, HL AF Valente, Mattia A. E. Voors, Adriaan A. Damman, Kevin Van Veldhuisen, Dirk J. Massie, Barrie M. O'Connor, Christopher M. Metra, Marco Ponikowski, Piotr Teerlink, John R. Cotter, Gad Davison, Beth Cleland, John G. F. Givertz, Michael M. Bloomfield, Daniel M. Fiuzat, Mona Dittrich, Howard C. Hillege, Hans L. TI Diuretic response in acute heart failure: clinical characteristics and prognostic significance SO EUROPEAN HEART JOURNAL LA English DT Article DE Diuretics; Heart failure; Diuretic resistance; Cardiorenal syndrome; Worsening renal function; Renal dysfunction; Prognosis; Mortality; Rehospitalization ID WORSENING RENAL-FUNCTION; CARDIORENAL SYNDROME; CONTINUOUS-INFUSION; BOLUS INJECTION; DYSPNEA RELIEF; ROLOFYLLINE; FUROSEMIDE; MORTALITY; ULTRAFILTRATION; RESISTANCE AB Aim Diminished diuretic response is common in patients with acute heart failure, although a clinically useful definition is lacking. Our aim was to investigate a practical, workable metric for diuretic response, examine associated patient characteristics and relationships with outcome. Methods and results We examined diuretic response (defined as Delta weight kg/40 mg furosemide) in 1745 hospitalized acute heart failure patients from the PROTECT trial. Day 4 response was used to allow maximum differentiation in responsiveness and tailoring of diuretic doses to clinical response, following sensitivity analyses. We investigated predictors of diuretic response and relationships with outcome. The median diuretic response was -0.38 (-0.80 to -0.13) kg/40 mg furosemide. Poor diuretic response was independently associated with low systolic blood pressure, high blood urea nitrogen, diabetes, and atherosclerotic disease (all P < 0.05). Worse diuretic response independently predicted 180-day mortality (HR: 1.42; 95% CI: 1.11-1.81, P = 0.005), 60-day death or renal or cardiovascular rehospitalization (HR: 1.34; 95% CI: 1.14-1.59, P < 0.001) and 60-day HF rehospitalization (HR: 1.57; 95% CI: 1.24-2.01, P < 0.001) in multivariable models. The proposed metric-weight loss indexed to diuretic dose-better captures a dose-response relationship. Model diagnostics showed diuretic response provided essentially the same or slightly better prognostic information compared with its individual components (weight loss and diuretic dose) in this population, while providing a less biased, more easily interpreted signal. Conclusions Worse diuretic response was associated with more advanced heart failure, renal impairment, diabetes, atherosclerotic disease and in-hospital worsening heart failure, and predicts mortality and heart failure rehospitalization in this post hoc, hypothesis-generating study. C1 [Valente, Mattia A. E.; Voors, Adriaan A.; Damman, Kevin; Van Veldhuisen, Dirk J.; Hillege, Hans L.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 AV Groningen, Netherlands. [Massie, Barrie M.; Teerlink, John R.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Massie, Barrie M.; Teerlink, John R.] San Francisco VA Med Ctr, San Francisco, CA USA. [O'Connor, Christopher M.; Fiuzat, Mona] Duke Univ, Med Ctr, Durham, NC USA. [Metra, Marco] Univ Brescia, Brescia, Italy. [Ponikowski, Piotr] Med Univ, Clin Mil Hosp, Wroclaw, Poland. [Cotter, Gad; Davison, Beth] Momentum Res, Durham, NC USA. [Cleland, John G. F.] Univ Hull, Kingston Upon Hull, Yorks, England. [Givertz, Michael M.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Bloomfield, Daniel M.] Merck Res Labs, Rahway, NJ USA. [Dittrich, Howard C.] Univ Iowa, Cardiovasc Res Ctr, Carver Coll Med, Iowa City, IA USA. [Hillege, Hans L.] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713 GZ Groningen, Netherlands. RP Voors, AA (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 AV Groningen, Netherlands. EM a.a.voors@umcg.nl RI Ponikowski, Piotr/O-6454-2015 OI Ponikowski, Piotr/0000-0002-3391-7064; Davison, Beth/0000-0003-2374-6449; Cleland, John/0000-0002-1471-7016; Metra, Marco/0000-0001-6691-8568 FU Merck; NovaCardia; Amgen; BG Medicine; Biocontrol; Johnson and Johnson; Novartis; Sorbent; Vifor; Abbott; Biogen Idec; Corthera; Cytokinetics; Johnson and Johnson/ Scios; Relypsa; Solvay FX M.A.E.V, K. D., M. F., and H. L. H. have nothing to disclose. A. A. V. has received speaker and consultancy fees from Merck and NovaCardia. D.J.V.V. has received Board Membership fees from Amgen, BG Medicine, Biocontrol, Johnson and Johnson, Novartis, Sorbent, and Vifor. B. M. M. has received consulting fees from NovaCardia, sponsors of the study, and from Merck, that purchased the rights to rolofylline after the completion of the PROTECT pilot study. C.M.O.C. is a consultant to Merck. M. M. has received honoraria and reimbursements from NovaCardia, sponsors of the study, and from Merck, that purchased the rights to rolofylline after completion of the PROTECT pilot study. P. P. has received honoraria from Merck. J.R.T. has received research funds and consulting fees from Merck, the producer of rolofylline for the conduct of this study and has also received research funds and consulting fees from Abbott, Amgen, Biogen Idec, Corthera, Cytokinetics, Johnson and Johnson/ Scios, Novartis, Relypsa, and Solvay for research in related areas. G. C. and B. A. W. are employees of Momentum Research, Inc., which was contracted to perform work on the project by Merck & Co., Inc., J.G.F.C. was on the Steering Committee for the study, served on the Advisory Board for MSD, and received payments for both. M. M. G. has received institutional research support and served on a scientific Advisory Board for Merck. D. A. B. is an employee of Merck. H. C. D was an employee of NovaCardia and a consultant to Merck. NR 49 TC 39 Z9 40 U1 1 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0195-668X EI 1522-9645 J9 EUR HEART J JI Eur. Heart J. PD MAY PY 2014 VL 35 IS 19 BP 1284 EP + DI 10.1093/eurheartj/ehu065 PG 11 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AI6QB UT WOS:000336999400014 PM 24585267 ER PT J AU Lee, SJ AF Lee, Sei J. TI So Much Insulin, So Much Hypoglycemia SO JAMA INTERNAL MEDICINE LA English DT Editorial Material ID OLDER PATIENTS; RISK C1 [Lee, Sei J.] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94121 USA. [Lee, Sei J.] San Francisco VA Med Ctr, Div Geriatr, San Francisco, CA USA. RP Lee, SJ (reprint author), Univ Calif San Francisco, San Francisco VA Med Ctr, Div Geriatr, 4150 Clement St,Bldg 1,Room 220F, San Francisco, CA 94121 USA. EM sei.lee@ucsf.edu FU NIA NIH HHS [K23 AG040779, P30 AG044281] NR 11 TC 5 Z9 5 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD MAY PY 2014 VL 174 IS 5 BP 686 EP 688 DI 10.1001/jamainternmed.2013.13307 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AI4NS UT WOS:000336842700008 PM 24614940 ER PT J AU Makam, AN Auerbach, AD Steinman, MA AF Makam, Anil N. Auerbach, Andrew D. Steinman, Michael A. TI Blood Culture Use in the Emergency Department in Patients Hospitalized for Community-Acquired Pneumonia SO JAMA INTERNAL MEDICINE LA English DT Letter C1 [Makam, Anil N.] Univ Texas SW Med Ctr Dallas, Div Gen Internal Med, Dallas, TX 75390 USA. [Auerbach, Andrew D.] Univ Calif San Francisco, Div Hosp Med, San Francisco, CA 94143 USA. [Steinman, Michael A.] San Francisco VA Med Ctr, Div Geriatr, San Francisco, CA USA. [Steinman, Michael A.] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Makam, AN (reprint author), Univ Texas SW Med Ctr Dallas, Div Gen Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM anil.makam@utsouthwestern.edu OI Makam, Anil/0000-0001-7072-9946 FU NIA NIH HHS [K23 AG030999]; PHS HHS [T32HP19025-07-00] NR 7 TC 7 Z9 7 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD MAY PY 2014 VL 174 IS 5 BP 803 EP 806 DI 10.1001/jamainternmed.2013.13808 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AI4NS UT WOS:000336842700030 PM 24614986 ER PT J AU Blanco, CL Moreira, AG McGill-Vargas, LL Anzueto, DG Nathanielsz, P Musi, N AF Blanco, Cynthia L. Moreira, Alvaro G. McGill-Vargas, Lisa L. Anzueto, Diana G. Nathanielsz, Peter Musi, Nicolas TI Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle SO JOURNAL OF ENDOCRINOLOGY LA English DT Article DE insulin; fetus; primate; muscle; glucocorticoid; corticosteroid; preterm ID BRONCHOPULMONARY DYSPLASIA; GLUCOSE-HOMEOSTASIS; PRETERM INFANTS; KINASE-B; GROWTH; DEXAMETHASONE; FETUS; GLUCOCORTICOIDS; HYPERGLYCEMIA; RESISTANCE AB We hypothesize that prenatal exposure to glucocorticoids (GCs) negatively alters the insulin signal transduction pathway and has differing effects on the fetus according to gestational age (GA) at exposure. Twenty-three fetal baboons were delivered from 23 healthy, nondiabetic mothers. Twelve preterm (0.67 GA) and 11 near-term (0.95 GA) baboons were killed immediately after delivery. Half of the pregnant baboons at each gestation received two doses of i.m. betamethasone 24 h apart (170 mg/kg) before delivery, while the other half received no intervention. Vastus lateralis muscle was obtained from postnatal animals tomeasure the protein content and gene expression of insulin receptor beta (IRb; INSR), IRb Tyr 1361 phosphorylation (pIRb), IR substrate 1 (IRS1), IRS1 tyrosine phosphorylation (pIRS1), p85 subunit of PI3-kinase, AKT (protein kinase B), phospho-AKT Ser473 (pAKT), AKT1, AKT2, and glucose transporters (GLUT1 and GLUT4). Skeletal muscle from preterm baboons exposed to GCs had markedly reduced protein content of AKTand AKT1 (respectively, 73 and 72% from 0.67 GA control, P! 0.001); IRb and pIRb were also decreased (respectively, 94 and 85%, P! 0.01) in themuscle of premature GCexposedfetusesbut not intermfetuses. GLUT1andGLUT4tendedto increasewithGCexposure in preterm animals (PZ0.09), while GLUT4 increased sixfold in term animals after exposure to GC (P! 0.05). In conclusion, exposure to a single course of antenatal GCs during fetal life alters the insulin signaling pathway in fetal muscle in a manner dependent on the stage of gestation. C1 [Blanco, Cynthia L.; Moreira, Alvaro G.; McGill-Vargas, Lisa L.; Anzueto, Diana G.] Univ Texas Hlth Sci Ctr San Antonio, Div Neonatol, Dept Pediat, San Antonio, TX 78229 USA. [Musi, Nicolas] Univ Texas Hlth Sci Ctr San Antonio, Diabet Div, Dept Med, San Antonio, TX 78229 USA. [Musi, Nicolas] South Texas Vet Hlth Care Syst, Ctr Geriatr Res Educ & Clin, San Antonio, TX 78229 USA. [Musi, Nicolas] Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA. [Nathanielsz, Peter] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA. RP Blanco, CL (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Neonatol, Dept Pediat, San Antonio, TX 78229 USA. EM blanco@uthscsa.edu OI Nathanielsz, Peter/0000-0001-8410-6280 FU Robert Wood Johnson Foundation; UTHSCSA CTSA [UL1RR025767]; American Diabetes Association; National Institutes of Health [HL52636, AG030979] FX This work was supported by grants from the Robert Wood Johnson Foundation (C L B), UTHSCSA CTSA (UL1RR025767; C L B), American Diabetes Association (C L B and N M), the National Institutes of Health (HL52636 to BPD resource Center, AG030979 to N M), P51RR13986 for facility support at the Southwest Foundation for Biomedical Research, the San Antonio Nathan Shock Center (N M), the UTHSCSA Executive Research Committee (N M), and the South Texas Health Research Center (N M). NR 40 TC 5 Z9 5 U1 0 U2 2 PU BIOSCIENTIFICA LTD PI BRISTOL PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT, ENGLAND SN 0022-0795 EI 1479-6805 J9 J ENDOCRINOL JI J. Endocrinol. PD MAY PY 2014 VL 221 IS 2 BP 253 EP 260 DI 10.1530/JOE-13-0504 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AI7WC UT WOS:000337110900012 PM 24756099 ER PT J AU Gong, JJ Munoz, AR Chan, D Ghosh, R Kumar, AP AF Gong, Jingjing Munoz, Amanda R. Chan, Daniel Ghosh, Rita Kumar, Addanki P. TI STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth SO ONCOTARGET LA English DT Article DE Pancreatic cancer; Nexrutine (R); STAT3; inflammation; autophagy; LC3 ID PROSTATE-CANCER; BINDING-PROTEIN; DEATH; NEXRUTINE; APOPTOSIS; ACTIVATION; RECEPTOR; AKT; ADENOCARCINOMA; GLIOBLASTOMA AB The dismal 5-year survival (<5%) for pancreatic cancer (PanCA) underscores the need for developing effective therapeutic options. Recent studies from our laboratory have shown that Nexrutine (R) (Nx), a bark extract from Phellodendron amurense exhibits excellent anticancer activity in human pancreatic cancer cells through inhibition of inflammatory signaling via STAT3/NF kappa B/Cox-2. Given the apparent high oxidative stress and autophagic activity in pancreatic tumors, we investigated the potential of Nx to modulate autophagy, reactive oxygen species (ROS), and their crosstalk. Our results show that Nx inhibits autophagy and decreases ROS generation. Pharmacological inhibition of autophagy led to decreased ROS generation and proliferation with no significant effect on apoptosis. Further, using combination index analysis we also found that combination of late-stage autophagy inhibitor with Nx exhibited a moderate synergistic to additive effect. Additionally, genetic or pharmacological inactivation of STAT3 reduced LC3-II levels and expression indicating a possible role for STAT3 in transcriptional regulation of autophagy. Since both inflammatory and oxidative stress signaling activate STAT3, our data implicates that STAT3 plays a vital role in the regulation of autophagy through its contributions to the positive feedback loop between ROS and autophagy. Overall, our findings reveal an important role for STAT3/LC3/ROS in Nx-mediated anti-pancreatic cancer effects. C1 [Gong, Jingjing; Munoz, Amanda R.; Ghosh, Rita; Kumar, Addanki P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. [Chan, Daniel] Univ Colorado, Div Med Oncol, Aurora, CO USA. [Ghosh, Rita; Kumar, Addanki P.] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA. [Kumar, Addanki P.] Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. RP Kumar, AP (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. EM kumara3@uthscsa.edu FU NCCAM [AT005513-01A1, AT 007448-01]; Veterans Affairs-Merit Award [1 I01 BX 000766-01]; NCI [1R01 CA149516]; TST predoctoral fellowship [8UL1 TR000149]; Cancer Therapy and Research Center at University of Texas Health Science Center San Antonio through the National Cancer Institute [2P30 CA 054174-17] FX This work was supported in part by funds from NCCAM AT005513-01A1, AT 007448-01 and Veterans Affairs-Merit Award 1 I01 BX 000766-01(APK); NCI 1R01 CA149516 (RG); TST predoctoral fellowship 8UL1 TR000149 (JJ). We acknowledge support provided by flow cytometry and optical imaging cores of Cancer Therapy and Research Center at University of Texas Health Science Center San Antonio through the National Cancer Institute support grant # 2P30 CA 054174-17 (APK). NR 63 TC 20 Z9 22 U1 0 U2 6 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD MAY PY 2014 VL 5 IS 9 BP 2529 EP 2541 PG 13 WC Oncology; Cell Biology SC Oncology; Cell Biology GA AI6FI UT WOS:000336966600016 PM 24796733 ER PT J AU Perandones, C Giugni, JC Calvo, DS Raina, GB Lopez, LDJ Volpini, V Zabetian, CP Mata, IF Caputo, M Corach, D Radrizzani, M Micheli, FE AF Perandones, C. Giugni, J. C. Calvo, D. S. Raina, G. B. De Jorge Lopez, L. Volpini, V. Zabetian, C. P. Mata, I. F. Caputo, M. Corach, D. Radrizzani, M. Micheli, F. E. TI Mosaicism of alpha-synuclein gene rearrangements: Report of two unrelated cases of early-onset parkinsonism SO PARKINSONISM & RELATED DISORDERS LA English DT Letter DE Parkinson's disease; alpha-Synuclein; Mosaicism; Gene multiplication ID DISEASE; MITOCHONDRIAL; DUPLICATION; DNA C1 [Perandones, C.; Giugni, J. C.; Calvo, D. S.; Raina, G. B.; Micheli, F. E.] Univ Buenos Aires, Parkinsons Dis & Movement Disorders Program, Hosp Clin, RA-1053 Buenos Aires, DF, Argentina. [Perandones, C.] Natl Agcy Labs & Hlth Inst Argentina ANUS, Buenos Aires, DF, Argentina. [De Jorge Lopez, L.; Volpini, V.] Inst Invest Biomed Bellvitge, Barcelona, Spain. [Zabetian, C. P.; Mata, I. F.] Univ Washington, Seattle, WA 98195 USA. [Zabetian, C. P.; Mata, I. F.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Caputo, M.; Corach, D.] Univ Buenos Aires, Sch Pharm & Biochem, Serv Huellas Digit Genet, RA-1053 Buenos Aires, DF, Argentina. [Radrizzani, M.] Natl Univ San Martin, CONICET, Lab Neuro & Mol Cytogenet, Buenos Aires, DF, Argentina. RP Perandones, C (reprint author), Univ Buenos Aires, Parkinsons Dis & Movement Disorders Program, Hosp Clin, Ciudad Autonoma Buenos Aires C1120AAR, RA-1053 Buenos Aires, DF, Argentina. EM claudia.perandones@gmail.com OI Zabetian, Cyrus/0000-0002-7739-4306 FU NINDS NIH HHS [R01 NS065070] NR 9 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8020 EI 1873-5126 J9 PARKINSONISM RELAT D JI Parkinsonism Relat. Disord. PD MAY PY 2014 VL 20 IS 5 BP 558 EP 561 DI 10.1016/j.Parkreldis.2013.11.014 PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA AI7LE UT WOS:000337071300017 PM 24552873 ER PT J AU Findlay, VJ Wang, C Watson, DK Camp, ER AF Findlay, V. J. Wang, C. Watson, D. K. Camp, E. R. TI Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer SO CANCER GENE THERAPY LA English DT Review ID EPIDERMAL-GROWTH-FACTOR; METASTATIC COLON-CANCER; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; E-CADHERIN EXPRESSION; BREAST-CANCER; RECTAL-CANCER; PANCREATIC-CANCER; DOWN-REGULATION; FACTOR RECEPTOR AB Although mortality from colorectal cancer (CRC) is decreasing, CRC is still the second highest cause of cancer-related deaths in America. Chemotherapy and radiation therapy now have central roles in our strategies to fight cancer, although we continue to lack novel strategies overcoming therapeutic resistance. Molecular mechanisms of therapeutic resistance in CRC continue to be under intense investigation. In this review, we highlight the recent evidence linking epithelial-to-mesenchynnal transition (EMT) with aggressive tumor biology as well as with the cancer stem cells (CSCs) across multiple organ systems including colon cancer. Furthermore, in the era of neo-adjuvant treatment, the clinical implications are concerning that our treatments may have the potential to induce more aggressive cancer cells through EMT, perhaps even generating CSCs more capable of metastasis and further resistant to treatment. This concern and potential reality highlights the critical need for further understanding the impact of clinical therapy on the pathobiology of cancer and further supports the need to therapeutically target the CSC. Besides serving as potential biomarkers for aggressive tumor biology and therapeutic resistance, EMT and CSC molecular pathways may highlight novel therapeutic targets as strategies for improving the response to conventional anti-neoplastic agents translating into improved oncologic outcomes. C1 [Findlay, V. J.; Watson, D. K.] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA. [Wang, C.; Camp, E. R.] Med Univ S Carolina, Dept Surg, Div Surg Oncol, Charleston, SC 29425 USA. [Watson, D. K.] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA. [Watson, D. K.; Camp, E. R.] Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA. [Camp, E. R.] Med Univ S Carolina, Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USA. RP Camp, ER (reprint author), Med Univ S Carolina, Dept Surg, Div Surg Oncol, 25 Courtenay Dr,Room 7018, Charleston, SC 29425 USA. EM campe@musc.edu FU National Institutes of Health [5R 1K08CA142904]; Hollings Cancer Center Translational Research Award; American Cancer Society: Institutional Research Grant FX This study was supported by National Institutes of Health, 5R 1K08CA142904 (ERC), Hollings Cancer Center Translational Research Award and American Cancer Society: Institutional Research Grant. NR 106 TC 43 Z9 45 U1 3 U2 21 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0929-1903 EI 1476-5500 J9 CANCER GENE THER JI Cancer Gene Ther. PD MAY PY 2014 VL 21 IS 5 BP 181 EP 187 DI 10.1038/cgt.2014.15 PG 7 WC Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity; Research & Experimental Medicine GA AI3QK UT WOS:000336776800002 PM 24787239 ER PT J AU Laserna, E Sibila, O Fernandez, JF Maselli, DJ Mortensen, EM Anzueto, A Waterer, G Restrepo, MI AF Laserna, Elena Sibila, Oriol Fernandez, Juan Felipe Maselli, Diego Jose Mortensen, Eric M. Anzueto, Antonio Waterer, Grant Restrepo, Marcos I. TI Impact of Macrolide Therapy in Patients Hospitalized With Pseudomonas aeruginosa Community-Acquired Pneumonia SO CHEST LA English DT Article ID BACTEREMIC PNEUMOCOCCAL PNEUMONIA; RANDOMIZED CONTROLLED-TRIAL; CARE-ASSOCIATED PNEUMONIA; GRAM-NEGATIVE BACILLI; RISK-FACTORS; BETA-LACTAM; MORTALITY; OUTCOMES; AZITHROMYCIN; EXACERBATIONS AB Background: Several studies have described a clinical benefit of macrolides due to their immunomodulatory properties in various respiratory diseases. We aimed to assess the effect of macrolide therapy on mortality in patients hospitalized for Pseudomonas aeruginosa community-acquired pneumonia (CAP). Methods: We performed a retrospective population-based study of > 150 hospitals in the US Veterans Health Administration. Patients were included if they had a diagnosis of CAP and P aeruginosa was identified as the causative pathogen. Patients with health-care-associated pneumonia and immunosuppression were excluded. Macrolide therapy was considered when administered within the first 48 h of admission. Univariate and multivariable analyses were performed using 30-day mortality as the dependent measure. Results: We included 402 patients with P aeruginosa CAP, of whom 171 (42.5%) received a macrolide during the first 48 h of admission. These patients were older and white. Macrolide use was not associated with lower 30-day mortality (hazard ratio, 1.14; 95% CI, 0.70-1.83; P=.5). In addition, patients treated with macrolides had no differences in ICU admission, use of mechanical ventilation, use of vasopressors, and length of stay (LOS) compared with patients not treated with macrolides. A subgroup analysis among patients with P aeruginosa CAP in the ICU showed no differences in baseline characteristics and outcomes. Conclusions: Macrolide therapy in the first 48 h of admission is not associated with decreased 30-day mortality, ICU admission, need for mechanical ventilation, and LOS in hospitalized patients with P aeruginosa CAP. Larger cohort studies should address the benefit of macrolides as immuno-modulators in patients with P aeruginosa CAP. C1 [Laserna, Elena] Hosp Comarcal de Mollet, Mollet Del Valles, Spain. [Laserna, Elena; Sibila, Oriol; Fernandez, Juan Felipe; Maselli, Diego Jose; Anzueto, Antonio; Restrepo, Marcos I.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Sibila, Oriol] Hosp Santa Creu & Sant Pau, Serv Pneumol, Barcelona, Spain. [Sibila, Oriol] Inst Invest Biomed St Pau, Barcelona, Spain. [Fernandez, Juan Felipe; Maselli, Diego Jose; Anzueto, Antonio; Restrepo, Marcos I.] South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. [Mortensen, Eric M.] North Texas Vet Hlth Care Syst, Dallas, TX USA. [Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Waterer, Grant] Univ Western Australia, Perth, WA 6009, Australia. [Waterer, Grant] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. RP Restrepo, MI (reprint author), South Texas Vet Hlth Care Syst, Audrey L Murphy Div, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA. EM restrepom@uthscsa.edu RI Restrepo, Marcos/H-4442-2014 OI Mortensen, Eric/0000-0002-3880-5563 FU Howard Hughes Medical Institute faculty [00378-001]; Department of Veterans Affairs Veterans Integrated Service Network 17 new faculty grant; Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR); Societat Catalana de Pneumologia (SOCAP); Fundacio Catalana de Pneumologia (FUCAP); Instituto de Salud Carlos III [BAE11/00102] FX This research was supported by Howard Hughes Medical Institute faculty [Start-up Grant 00378-001] and a Department of Veterans Affairs Veterans Integrated Service Network 17 new faculty grant. Drs Laserna and Sibila are supported by Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR), Societat Catalana de Pneumologia (SOCAP), and Fundacio Catalana de Pneumologia (FUCAP). Dr Sibila is supported by Instituto de Salud Carlos III [BAE11/00102]. Dr Restrepo's time is partially protected by K23-HL096054 from the National Heart, Lung, and Blood Institute. NR 33 TC 4 Z9 4 U1 1 U2 4 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD MAY PY 2014 VL 145 IS 5 BP 1114 EP 1120 DI 10.1378/chest.13-1607 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AI0IZ UT WOS:000336532100029 PM 24458223 ER PT J AU Naik, AD AF Naik, Aanand D. TI Peering Inside the Black Box of Patient-Centered Care SO CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES LA English DT Editorial Material DE Ediorials; health care quality, access, and evaluation; decision support techniques; patient-centered care; patient participation; shared decision making ID DECISION-MAKING; DIABETES-MELLITUS; ENDOSCOPY C1 [Naik, Aanand D.] Michael E DeBakey VA Med Ctr, Ctr Innovat Qual Effectiveness & Safety IQuESt, Houston, TX USA. [Naik, Aanand D.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. RP Naik, AD (reprint author), Michael E DeBakey VA Med Ctr 152, Houston Ctr Innovat Qual Effectiveness & Safety, 2002 Holcombe Blvd, Houston, TX 77030 USA. EM anaik@bcm.edu FU HSRD VA [I01 HX000486] NR 18 TC 0 Z9 0 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1941-7705 EI 1941-7713 J9 CIRC-CARDIOVASC QUAL JI Circ.-Cardiovasc. Qual. Outcomes PD MAY PY 2014 VL 7 IS 3 BP 347 EP 349 DI 10.1161/CIRCOUTCOMES.114.001038 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AI3WQ UT WOS:000336796300001 PM 24823950 ER PT J AU Kangovi, S Levy, K Barg, FK Carter, T Long, JA Grande, D AF Kangovi, Shreya Levy, Kathryn Barg, Frances K. Carter, Tamala Long, Judith A. Grande, David TI Perspectives of Older Adults of Low Socioeconomic Status on the Post-hospital Transition SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED LA English DT Article DE Low socioeconomic status; dually-eligible individuals; post-hospital transition; disparities ID RANDOMIZED CONTROLLED-TRIAL; LOW-INCOME SENIORS; HEART-FAILURE; MEDICARE BENEFICIARIES; CARE; READMISSION; EXPERIENCES; MORTALITY; QUALITY; HEALTH AB Background. Older adults of low socioeconomic status are at high risk for poor post-hospital outcomes. Design. A qualitative researcher, who was also an outreach worker from the West Philadelphia community, conducted in-depth interviews with 25 participants within 30 days of their hospital discharge. Participants. Eligible participants were: 1) residents of high-poverty ZIP codes; 2) dually eligible for Medicare and Medicaid; 3) had capacity or a caregiver who could be interviewed as a proxy; 4) general medicine or cardiology patients. Results. Participants were unable to access the care and accommodations needed to cope with post-hospital frailty. As a result, medical disability was amplified by socioeconomic disability. Participants were ashamed of the resulting loss of control and had difficulty asking for help, particularly from potential supports who were perceived as emotionally controlling or judgmental. Conclusion. Strategies that address socioeconomic stressors of hospitalization and provide empathic support may improve the post-hospital transition for these high-risk individuals. C1 [Kangovi, Shreya; Long, Judith A.] Philadelphia Vet Affairs Med Ctr, Philadelphia, PA USA. [Kangovi, Shreya] Univ Penn, Robert Wood Johnson Fdn Clin Scholars Program, Philadelphia, PA 19104 USA. [Kangovi, Shreya; Levy, Kathryn; Long, Judith A.; Grande, David] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA. [Kangovi, Shreya; Long, Judith A.; Grande, David] Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA. [Barg, Frances K.; Carter, Tamala] Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA. [Long, Judith A.] Philadelphia VA Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. RP Kangovi, S (reprint author), 1233 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM kangovi@upenn.edu NR 46 TC 2 Z9 2 U1 0 U2 9 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1049-2089 EI 1548-6869 J9 J HEALTH CARE POOR U JI J. Health Care Poor Underserved PD MAY PY 2014 VL 25 IS 2 BP 746 EP 756 PG 11 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AH7VJ UT WOS:000336343100025 PM 24858883 ER PT J AU Lyerly, MJ Albright, KC Boehme, AK Shahripour, RB Houston, JT Rawal, PV Kapoor, N Alvi, M Sisson, A Alexandrov, AW Alexandrov, AV AF Lyerly, Michael J. Albright, Karen C. Boehme, Amelia K. Shahripour, Reza Bavarsad Houston, James T. Rawal, Pawan V. Kapoor, Niren Alvi, Muhammad Sisson, April Alexandrov, Anne W. Alexandrov, Andrei V. TI Safety of Protocol Violations in Acute Stroke tPA Administration SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES LA English DT Article DE Acute ischemic stroke; thrombolysis; patient safety; protocol violation; symptomatic intracerebral hemorrhage ID ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN ACTIVATOR; OFF-LABEL THROMBOLYSIS; INTRAVENOUS THROMBOLYSIS; HEMORRHAGIC COMPLICATIONS; ALTEPLASE; US AB Background: Intravenous (IV) tissue plasminogen activator remains the only approved therapy for acute ischemic stroke (AIS) in the United States; however, less than 10% of patients receive treatment. This is partially because of the large number of contraindications, narrow treatment window, and physician reluctance to deviate from these criteria. Methods: We retrospectively analyzed consecutive patients who received IV thrombolysis at our stroke center for National Institute of Neurological Disorders and Stroke (NINDS) protocol violations and rates of symptomatic intracerebral hemorrhage (sICH). Other outcome variables included systemic hemorrhage, modified Rankin Scale at discharge, and discharge disposition. Results: A total of 212 patients were identified in our stroke registry between 2009 and 2011 and included in the analysis. Protocol violations occurred in 76 patients (36%). The most common violations were thrombolysis beyond 3 hours (26%), aggressive blood pressure management (15%), elevated prothrombin time (PT) or partial thromboplastin time (PTT) (6.6%), minor or resolving deficits (4.2%), unclear time of onset (3.9%), and stroke within 3 months (3%). There were no significant differences in any of the safety outcomes or discharge disposition between patients with or without protocol violations. Controlling for age, National Institutes of Health Stroke Scale on admission, and glucose on admission, there was no significant increase in sICH (odds ratio: 3.8; 95% confidence interval: .37-38.72) in the patients who had protocol violations. Conclusions: Despite more than one third of patients receiving thrombolysis with protocol violations, overall rates of hemorrhage remained low and did not differ from those who did not have violations. Our data support the need to expand access to thrombolysis in AIS patients. C1 [Lyerly, Michael J.; Albright, Karen C.; Boehme, Amelia K.; Shahripour, Reza Bavarsad; Houston, James T.; Rawal, Pawan V.; Kapoor, Niren; Alvi, Muhammad; Sisson, April; Alexandrov, Anne W.; Alexandrov, Andrei V.] Univ Alabama Birmingham, Dept Neurol, Sch Med, Birmingham, AL 35294 USA. [Lyerly, Michael J.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. [Albright, Karen C.; Boehme, Amelia K.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA. [Albright, Karen C.] Univ Alabama Birmingham, Hlth Serv, Birmingham, AL 35294 USA. [Albright, Karen C.] Univ Alabama Birmingham, Outcomes Res Ctr Outcome & Effectiveness Res & Ed, Birmingham, AL 35294 USA. [Albright, Karen C.] Univ Alabama Birmingham, Ctr Excellence Comparat Effectiveness Res Elimina, Minor Hlth & Hlth Dispar Res Ctr, Birmingham, AL 35294 USA. [Alexandrov, Anne W.] Univ Alabama Birmingham, Sch Nursing, Birmingham, AL 35294 USA. RP Lyerly, MJ (reprint author), Univ Alabama Birmingham, Dept Neurol, Stroke Program, 1813 6th Ave S,RWUH M226, Birmingham, AL 35294 USA. EM mjlyerly@uab.edu OI Alexandrov, Andrei V/0000-0001-8871-1023; Boehme, Amelia/0000-0002-7109-6025; Lyerly, Michael/0000-0003-4236-1018 FU Agency for Healthcare Research and Quality [5 T32 HS013852-10]; National Institute on Minority Health and Health Disparities [3 P60 MD000502-08S1]; National Institutes of Health; American Heart Association [13PRE13830003] FX K.C.A. is supported by award numbers 5 T32 HS013852-10 from The Agency for Healthcare Research and Quality, 3 P60 MD000502-08S1 from The National Institute on Minority Health and Health Disparities, and National Institutes of Health. A.K.B. is supported by award 13PRE13830003 from the American Heart Association. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Agency for Healthcare Research and Quality, American Heart Association, or the National Institutes of Health. NR 25 TC 9 Z9 9 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1052-3057 EI 1532-8511 J9 J STROKE CEREBROVASC JI J. Stroke Cerebrovasc. Dis. PD MAY-JUN PY 2014 VL 23 IS 5 BP 855 EP 860 DI 10.1016/j.jstrokecerebrovasdis.2013.07.019 PG 6 WC Neurosciences; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA AH9SI UT WOS:000336482000026 PM 23954609 ER PT J AU Montagnini, M Kaiser, RM Clark, PG Dodd, MA Goodwin, C Periyakoil, VS Ramsel, D Sanchez-Reilly, SE Semla, TP Smith, H Supiano, K Tsukuda, RA Zeiss, A OngChansanchai, LC AF Montagnini, Marcos Kaiser, Robert M. Clark, Phillip G. Dodd, Melanie A. Goodwin, Carol Periyakoil, Vyjeyanthi S. Ramsel, Dee Sanchez-Reilly, Sandra E. Semla, Todd P. Smith, Heather Supiano, Katherine Tsukuda, Ruth Ann Zeiss, Antonette OngChansanchai, Li-Chia CA Partnership Hlth Aging Workgrp Int TI Position Statement on Interdisciplinary Team Training in Geriatrics: An Essential Component of Quality Health Care for Older Adults SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE interdisciplinary; team training; geriatrics education ID RANDOMIZED CONTROLLED-TRIAL; ALL-INCLUSIVE CARE; INTERPROFESSIONAL EDUCATION; PROGRAM; MANAGEMENT; LESSONS; MODEL; PACE AB Interdisciplinary team training (IDT) is an important component of ensuring quality geriatric care delivery, which can be complex and time intensive, requiring coordination of many medical, psychosocial, and therapeutic interventions and professionals. The Partnership for Health in Aging (PHA), a loose coalition of more than 30 organizations representing healthcare professionals who care for older adults supported by the American Geriatrics Society, identified IDT training in geriatrics as a priority area in addressing the geriatrics workforce shortage described in the 2008 Institute of Medicine report, Retooling for An Aging America: Building the Health Care Workforce. A PHA Workgroup on Interdisciplinary Team Training in Geriatrics was convened to review the literature focused on geriatrics IDT training and to develop a position statement that would inform and influence groups involved in the development and expansion of academic and continuing education programs in IDT training, including professional associations, credentialing and licensing bodies, accreditation organizations, and university administrators. There are significant challenges to expanding the development and implementation of geriatrics IDT training for health professionals, and such training will be successful only with substantial and sustained advocacy from the above professional groups. C1 [Montagnini, Marcos] Univ Michigan, VA Ann Arbor Healthcare Syst, GRECC, Ann Arbor, MI 48109 USA. [Kaiser, Robert M.] George Washington Univ, Sch Med, DC Vet Affairs Med Ctr, Washington, DC USA. [Clark, Phillip G.] Univ Rhode Isl, Providence, RI 02908 USA. [Dodd, Melanie A.] Univ New Mexico, Coll Pharm, Albuquerque, NM 87131 USA. [Goodwin, Carol] Amer Geriatr Soc, New York, NY USA. [Periyakoil, Vyjeyanthi S.] Stanford Univ, Sch Med, Palo Alto Hlth Care Syst, Stanford, CA 94305 USA. [Ramsel, Dee] Med Coll Wisconsin, VHA Natl Ctr Org Dev, Milwaukee, WI 53226 USA. [Sanchez-Reilly, Sandra E.] Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. [Semla, Todd P.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Smith, Heather] Med Coll Wisconsin, Clement J Zablocki VAMC, Milwaukee, WI 53226 USA. [Supiano, Katherine] Univ Utah, Coll Nursing, Salt Lake City, UT 84112 USA. [Tsukuda, Ruth Ann] Portland VA Med Ctr, Portland, OR USA. [Zeiss, Antonette] Dept Vet Affairs, VA Cent Off, Washington, DC USA. RP Montagnini, M (reprint author), VA Ann Arbor Healthcare Syst, GRECC, 2215 Fuller Rd 11-G, Ann Arbor, MI 48105 USA. EM mmontag@umich.edu OI Supiano, Katherine/0000-0001-7267-7705 FU MedEd Portal Interprofessional Educational Collaborative Collection FX Dr. Dodd has received grant support from MedEd Portal Interprofessional Educational Collaborative Collection and a 10% salary release from Donald W. Reynolds Foundation Next Steps in Physician's Training in Geriatrics Grant. NR 48 TC 10 Z9 10 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD MAY PY 2014 VL 62 IS 5 BP 961 EP 965 DI 10.1111/jgs.12822 PG 5 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA AH8JY UT WOS:000336385300027 ER PT J AU Zhu, CW Sano, M Ferris, SH Whitehouse, PJ Patterson, MB Galasko, D Schneider, LS Aisen, PS AF Zhu, Carolyn W. Sano, Mary Ferris, Steven H. Whitehouse, Peter J. Patterson, Marian B. Galasko, Douglas Schneider, Lon S. Aisen, Paul S. TI ALZHEIMER'S DISEASE COOPERATIVE STUDY PREVENTION INSTRUMENT PROJECT ASSESSING RESOURCE USE AND VOLUNTEER AND PAID WORK IN HEALTHY ELDERS: A LONGITUDINAL STUDY SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Letter ID DEMENTIA C1 [Zhu, Carolyn W.] Mt Sinai Sch Med, Dept Geriatr & Palliat Med, New York, NY 10029 USA. [Sano, Mary] Mt Sinai Sch Med, Dept Psychiat, Alzheimer Dis Res Ctr, New York, NY USA. [Sano, Mary] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. [Ferris, Steven H.] NYU, Alzheimers Dis Ctr, Langone Med Ctr, New York, NY USA. [Whitehouse, Peter J.; Patterson, Marian B.] Case Western Reserve Univ, Dept Neurol, Cleveland, OH 44106 USA. [Galasko, Douglas; Aisen, Paul S.] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA. [Schneider, Lon S.] Univ So Calif, Keck Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90033 USA. [Schneider, Lon S.] Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA. RP Zhu, CW (reprint author), Mt Sinai Sch Med, Dept Geriatr & Palliat Med, New York, NY 10029 USA. OI Ferris, Steven/0000-0001-8641-6223 FU NIA NIH HHS [P30 AG008051, P50 AG005131, P50 AG005138, P50 AG005142, U01 AG010483, U01AG10483, U19 AG010483] NR 7 TC 0 Z9 0 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD MAY PY 2014 VL 62 IS 5 BP 985 EP 988 DI 10.1111/jgs.12816 PG 4 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA AH8JY UT WOS:000336385300040 PM 24828933 ER PT J AU Groah, SL Ljungberg, I Lichy, A Oyster, M Boninger, ML AF Groah, Suzanne L. Ljungberg, Inger Lichy, Alison Oyster, Michelle Boninger, Michael L. TI Disparities in Wheelchair Procurement by Payer Among People With Spinal Cord Injury SO PM&R LA English DT Article ID ELECTRIC-POWERED WHEELCHAIRS; MANUAL WHEELCHAIRS; ANSI/RESNA STANDARDS; PROPULSION; PARTICIPATION; BIOMECHANICS; DURABILITY; POSITION; COST AB Objective: To identify insurance provider-related disparities in the receipt of lightweight, customizable manual wheelchairs or power wheelchairs with programmable controls among community-dwelling people with spinal cord injury (SCI). Setting: Six Spinal Cord Injury Model System centers. Design: A multicenter cross-sectional study. Participants: A total of 359 individuals at least 16 years of age or older and 1 year after SCI who use a manual or power wheelchair as their. primary means of mobility. The subjects were stratified by payer, and payers were grouped according to reimbursement characteristics as follows: Medicaid/Department of Vocational Rehabilitation (DVR), private/prepaid, Medicare, Worker's Compensation (WC)/Veterans Affairs (VA), and self pay. Methods: Demographic, wheelchair, and payer data were collected by medical record review and face-to-face interview. Results: There were 125 participants in the Medicaid/DVR group, 120 in the private/ prepaid group, 55 in the Medicare group, 30 in the WC/VA group, and 29 in the self-pay group. For manual wheelchair users, the likelihood of having a lightweight, customizable wheelchair was 97.5% for private/prepaid, 96.3% for Medicaid/DVR, 94.1% for WC/VA, 87.5% for Medicare, and 82.6% for self pay. For power wheelchair users, those with WC/ VA (100%) were most likely to receive a customizable power wheelchair with programmable controls, followed by private/prepaid (95.1%), Medicaid/DVR (86.0 %), Medicare (83.9%), and self pay (50.0%). Conclusions: The only payer group for which all beneficiaries received wheelchairs that met standard of care were power wheelchairs provided by WC/VA. Fewer than 90% of people whose manual wheelchair was paid for by Medicare and self pay, and whose power wheelchair was paid for by Medicaid/DVR, Medicare, and self pay did not meet standard of care. Although these findings need to be correlated with long-term risks, such as overuse injuries, breakdowns, and participation, this study demonstrates that disparities in wheelchair procurement by insurance provider persist. C1 [Groah, Suzanne L.] Natl Rehabil Hosp, Washington, DC 20010 USA. [Ljungberg, Inger; Lichy, Alison] MedStar Natl Rehabil Hosp, Washington, DC USA. [Oyster, Michelle; Boninger, Michael L.] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA USA. [Oyster, Michelle; Boninger, Michael L.] VA Pittsburgh Healthcare Syst, Sch Med, Pittsburgh, PA USA. [Oyster, Michelle; Boninger, Michael L.] VA Pittsburgh Healthcare Syst, Ctr Excellence Wheelchairs & Associated Rehabil E, Pittsburgh, PA USA. RP Groah, SL (reprint author), Natl Rehabil Hosp, 102 Irving St, Washington, DC 20010 USA. EM suzanne.l.groah@medstar.net OI Boninger, Michael/0000-0001-6966-919X FU Department of Education/National Institute on Disability and Rehabilitation Research; National Institute on Disability and Rehabilitation Research FX grant, Department of Education/National Institute on Disability and Rehabilitation Research; Grant, National Institute on Disability and Rehabilitation Research NR 24 TC 3 Z9 3 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD MAY PY 2014 VL 6 IS 5 BP 412 EP 417 DI 10.1016/j.pmrj.2013.11.004 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI0SR UT WOS:000336560700007 PM 24211695 ER PT J AU Furman, MB Plastaras, CT Popescu, A Tekmyster, G Davidoff, S Kennedy, DJ AF Furman, Michael B. Plastaras, Christopher T. Popescu, Adrian Tekmyster, Gene Davidoff, Scott Kennedy, David J. TI Should Antiplatelet Medications Be Held Before Cervical Epidural Injections? SO PM&R LA English DT Editorial Material ID THERAPY; DISCONTINUATION; CLOPIDOGREL; RISK; PAIN C1 [Furman, Michael B.] OSS Hlth, York, PA USA. [Plastaras, Christopher T.] Univ Penn, Dept Phys Med & Rehabil, Perelman Sch Med, Penn Spine Ctr, Philadelphia, PA 19104 USA. [Popescu, Adrian] Hosp Univ Penn, Philadelphia VA Med Ctr, Pain Med Div, Dept Phys Med & Rehabil, Philadelphia, PA 19104 USA. [Tekmyster, Gene] Orthopaed & Sports Med Ctr, Trumbull, CT USA. [Davidoff, Scott] Main Line Spine, King Of Prussia, PA USA. [Kennedy, David J.] Stanford Univ, Dept Orthopaed, Redwood City, CA 94063 USA. RP Kennedy, DJ (reprint author), Stanford Univ, Dept Orthopaed, 450 Broadway St,MC 6342, Redwood City, CA 94063 USA. EM djkenned@stanford.edu NR 14 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD MAY PY 2014 VL 6 IS 5 BP 442 EP 445 DI 10.1016/j.pmrj.2014.04.012 PG 4 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI0SR UT WOS:000336560700011 PM 24863733 ER PT J AU Furman, MB Plastaras, CT Popescu, A Tekmyster, G Davidoff, S Kennedy, DJ AF Furman, Michael B. Plastaras, Christopher T. Popescu, Adrian Tekmyster, Gene Davidoff, Scott Kennedy, David J. TI Should Antiplatelet Medications Be Held Before Cervical Epidural Injections? Response SO PM&R LA English DT Editorial Material ID TRANSFORAMINAL INJECTIONS; PERIOPERATIVE MANAGEMENT; CLOPIDOGREL THERAPY; PRACTICE GUIDELINES; EUROPEAN-SOCIETY; CARDIOLOGY ESC; TASK-FORCE; STENT; IMPLANTATION; DURATION C1 [Furman, Michael B.] OSS Hlth, York, PA USA. [Plastaras, Christopher T.] Univ Penn, Penn Spine Ctr, Perelman Sch Med, Dept Phys Med & Rehabil, Philadelphia, PA 19104 USA. [Popescu, Adrian] Hosp Univ Penn, Philadelphia VA Med Ctr, Pain Med Div, Dept Phys Med & Rehabil, Philadelphia, PA 19104 USA. [Tekmyster, Gene] Orthopaed & Sports Med Ctr, Trumbull, CT USA. [Davidoff, Scott] Main Line Spine, King Of Prussia, PA USA. [Kennedy, David J.] Stanford Univ, Dept Orthopaed, Redwood City, CA 94063 USA. RP Kennedy, DJ (reprint author), Stanford Univ, Dept Orthopaed, 450 Broadway St,MC 6342, Redwood City, CA 94063 USA. EM djkenned@stanford.edu NR 19 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD MAY PY 2014 VL 6 IS 5 BP 445 EP 447 PG 3 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI0SR UT WOS:000336560700012 ER PT J AU Furman, MB Plastaras, CT Popescu, A Tekmyster, G Davidoff, S Kennedy, DJ AF Furman, Michael B. Plastaras, Christopher T. Popescu, Adrian Tekmyster, Gene Davidoff, Scott Kennedy, David J. TI Should Antiplatelet Medications Be Held Before Cervical Epidural Injections? SO PM&R LA English DT Editorial Material ID ANGIOGRAPHY C1 [Furman, Michael B.] OSS Hlth, York, PA USA. [Plastaras, Christopher T.] Univ Penn, Penn Spine Ctr, Perelman Sch Med, Dept Phys Med & Rehabil, Philadelphia, PA 19104 USA. [Popescu, Adrian] Hosp Univ Penn, Dept Phys Med & Rehabil, Pain Med Div, Philadelphia VA Med Ctr, Philadelphia, PA 19104 USA. [Tekmyster, Gene] Orthopaed & Sports Med Ctr, Trumbull, CT USA. [Davidoff, Scott] Main Line Spine, King Of Prussia, PA USA. [Kennedy, David J.] Stanford Univ, Dept Orthopaed, Redwood City, CA 94063 USA. RP Kennedy, DJ (reprint author), Stanford Univ, Dept Orthopaed, 450 Broadway St,MC 6342, Redwood City, CA 94063 USA. EM djkenned@stanford.edu NR 5 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD MAY PY 2014 VL 6 IS 5 BP 447 EP 448 PG 2 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI0SR UT WOS:000336560700013 ER PT J AU Furman, MB Plastaras, CT Popescu, A Tekmyster, G Davidoff, S Kennedy, DJ AF Furman, Michael B. Plastaras, Christopher T. Popescu, Adrian Tekmyster, Gene Davidoff, Scott Kennedy, David J. TI Should Antiplatelet Medications Be Held Before Cervical Epidural Injections? SO PM&R LA English DT Editorial Material ID LONG-TERM DURATION; HEMATOMA; THERAPY; MANAGEMENT; TRIAL; PAIN C1 [Furman, Michael B.] OSS Hlth, York, PA USA. [Plastaras, Christopher T.] Univ Penn, Dept Phys Med & Rehabil, Perelman Sch Med, Penn Spine Ctr, Philadelphia, PA USA. [Popescu, Adrian] Hosp Univ Penn, Philadelphia VA Med Ctr, Pain Med Div, Dept Phys Med & Rehabil, Philadelphia, PA 19104 USA. [Tekmyster, Gene] Orthopaed & Sports Med Ctr, Trumbull, CT USA. [Davidoff, Scott] Main Line Spine, King Of Prussia, PA USA. [Kennedy, David J.] Stanford Univ, Dept Orthopaed, Redwood City, CA 94063 USA. RP Kennedy, DJ (reprint author), Stanford Univ, Dept Orthopaed, 450 Broadway St,MC 6342, Redwood City, CA 94063 USA. EM djkenned@stanford.edu NR 13 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD MAY PY 2014 VL 6 IS 5 BP 448 EP 450 PG 3 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AI0SR UT WOS:000336560700014 ER PT J AU Samuelson, KW Koenig, CJ McCamish, N Choucroun, G Tarasovsky, G Bertenthal, D Seal, KH AF Samuelson, Kristin W. Koenig, Christopher J. McCamish, Nicole Choucroun, Gerard Tarasovsky, Gary Bertenthal, Daniel Seal, Karen H. TI Web-Based PTSD Training for Primary Care Providers: A Pilot Study SO PSYCHOLOGICAL SERVICES LA English DT Article DE posttraumatic stress disorder; primary care; veterans; Web-based ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL COMORBIDITY SURVEY; MENTAL-HEALTH DIAGNOSES; AFGHANISTAN VETERANS; FUNCTIONAL IMPAIRMENT; SURVEY REPLICATION; ANXIETY DISORDERS; IRAQ; SERVICES; BARRIERS AB Veterans with posttraumatic stress disorder (PTSD) symptoms frequently present to primary care providers (PCPs) and are reluctant to seek out or accept referrals to specialty mental health care. Most PCPs have not been trained to assess for and manage symptoms of PTSD. Web-based programs are increasingly used for medical education, but there are no published evaluations of online PTSD trainings for PCPs. We developed a 70-min Web-based training that focused on military-related PTSD for PCPs practicing in Veterans Affairs (VA) hospitals, but was applicable to PCPs treating veterans and other trauma-exposed patients outside VA settings. The training consisted of four modules: (1) Detection and Assessment; (2) Comorbid Conditions and Related Problems; (3) Pharmacological Interventions; and (4) Psychotherapeutic Interventions. Clinical vignettes dramatized key training concepts. Seventy-three PCPs completed the training and assessments pre- and posttraining and 30 days later. Paired t tests compared change in PTSD-related knowledge and comfort with PTSD-related skills, and qualitative methods were used to summarize participant feedback. After the training, mean knowledge score improved from 46% to 75% items correct, with sustained improvement at 30 days. Thirty days posttraining, PCPs reported significantly greater comfort regarding PTSD-related skills assessed; 47% reported using training content in their clinical practice. Qualitatively, PCPs appreciated the flexibility of asynchronous, self-paced online modules, but suggested more interactive content. Given the numerous barriers to specialty mental health treatment, coupled with a preference among veterans with PTSD for accessing treatment through primary care, improving PTSD competency among PCPs may help better serve veterans' mental health needs. C1 [Samuelson, Kristin W.] Alliant Int Univ, San Francisco Vet Affairs Med Ctr, San Francisco, CA 94133 USA. [Samuelson, Kristin W.] Alliant Int Univ, Dept Mental Hlth, San Francisco, CA 94133 USA. [Samuelson, Kristin W.] Alliant Int Univ, Calif Sch Profess Psychol, San Francisco, CA 94133 USA. [Koenig, Christopher J.; McCamish, Nicole; Choucroun, Gerard; Tarasovsky, Gary; Bertenthal, Daniel; Seal, Karen H.] San Francisco VA Med Ctr, Dept Med, San Francisco, CA USA. [Koenig, Christopher J.; McCamish, Nicole; Choucroun, Gerard; Tarasovsky, Gary; Bertenthal, Daniel] San Francisco VA Med Ctr, Dept Mental Hlth, San Francisco, CA USA. [Seal, Karen H.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Seal, Karen H.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. RP Samuelson, KW (reprint author), Alliant Int Univ, 1 Beach St,Suite 100, San Francisco, CA 94133 USA. EM ksamuelson@alliant.edu OI Koenig, Christopher J./0000-0003-0884-4120 NR 40 TC 0 Z9 0 U1 2 U2 8 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD MAY PY 2014 VL 11 IS 2 BP 153 EP 161 DI 10.1037/a0034855 PG 9 WC Psychology, Clinical SC Psychology GA AI3TC UT WOS:000336784900004 PM 24364595 ER PT J AU Mendez, MF Fong, SS Shapira, JS Jimenez, EE Kaiser, NC Kremen, SA Tsai, PH AF Mendez, Mario F. Fong, Sylvia S. Shapira, Jill S. Jimenez, Elvira E. Kaiser, Natalie C. Kremen, Sarah A. Tsai, Po-Heng TI Observation of Social Behavior in Frontotemporal Dementia SO AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS LA English DT Article DE dementia; frontotemporal lobar degeneration; Alzheimer's disease; social behavior; autism ID LOBAR DEGENERATION; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; MIND DEFICITS; RATING-SCALE; VARIANT; COGNITION; CONSENSUS AB Background: The most characteristic manifestations of behavioral variant frontotemporal dementia (bvFTD) are abnormalities in social behavior. However, distinguishing bvFTD based on social behavior can be difficult in structured clinical settings. Methods: Using a Social Observation Inventory, 10 patients with bvFTD and 10 patients with Alzheimer's disease (AD) were compared to their caregiver interlocutors on 1-hour mealtime, in-home videotaped segments. Results: Compared to caregivers and patients with AD, patients with bvFTD were significantly disturbed in social behavior. In contrast, patients with AD were indistinguishable from their caregivers. The lack of you comments and decreased tact and manners distinguished 92.6% of the patients with bvFTD from patients with AD and caregivers. The Social Observation Inventory scores correlated with scores on frontal-executive tests and socioemotional scales. Conclusions: The systematic observation of social behavior during routine activities may be one of the best ways to distinguish patients with bvFTD from normal individuals and from patients with other dementias. C1 [Mendez, Mario F.; Fong, Sylvia S.; Shapira, Jill S.; Jimenez, Elvira E.; Kaiser, Natalie C.; Kremen, Sarah A.; Tsai, Po-Heng] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA. [Mendez, Mario F.; Fong, Sylvia S.; Shapira, Jill S.; Jimenez, Elvira E.; Kaiser, Natalie C.; Tsai, Po-Heng] VA Greater Los Angeles Healthcare Ctr, Los Angeles, CA 90073 USA. RP Mendez, MF (reprint author), VA Greater Los Angeles Healthcare Ctr, Neurobehav Unit 691 116AF, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM mmendez@UCLA.edu FU NIH [R01AG034499-03] FX The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by NIH grant #R01AG034499-03. NR 37 TC 14 Z9 14 U1 2 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1533-3175 EI 1938-2731 J9 AM J ALZHEIMERS DIS JI Am. J. Alzheimers Dis. Other Dement. PD MAY PY 2014 VL 29 IS 3 BP 215 EP 221 DI 10.1177/1533317513517035 PG 7 WC Geriatrics & Gerontology; Clinical Neurology SC Geriatrics & Gerontology; Neurosciences & Neurology GA AI0HL UT WOS:000336527000005 PM 24370617 ER PT J AU Kasckow, J Golshan, S Zisook, S AF Kasckow, John Golshan, Shahrokh Zisook, Sidney TI Does Age Moderate the Relationship Between Depressive Symptoms and Suicidal Ideation in Middle-Aged and Older Patients with Schizophrenia and Subthreshold Depression? SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Article DE Age; depression; moderation; schizophrenia; suicidal ideation ID RATING-SCALE AB Background: Suicidal deaths in middle-aged and older individuals with schizophrenia are a public health concern. Depression and schizophrenia are major risk factors for suicide. However, it is unknown whether age moderates the relationship between depression and suicidal ideation in patients with schizophrenia and subthreshold depression. Methods: Suicidal ideation was assessed with the InterSePT Scale for Suicidal Ideation and the Clinical Global Impression-Suicide Severity Scale in outpatients older than 39 years with schizophrenia and subthreshold depression (n = 213). Using linear regression, we examined whether depression (based on Calgary Depression Rating Scale scores), age, and "age by depressive symptoms" predicted suicidal ideation. Results: Depressive symptoms predicted suicidal ideation. Neither age nor "depressive symptoms by age" predicted suicidal ideation. Conclusions: In this population, age does not appear to moderate the relationship between depressive symptoms and suicidal behavior. Thus, assessing depressive symptoms as a risk factor is important at all ages in this population. C1 [Kasckow, John] VA Pittsburgh Hlth Care Syst, MIRECC, Pittsburgh, PA 15240 USA. [Kasckow, John] Univ Pittsburgh, Med Ctr, Behav Hlth Serv, Pittsburgh, PA USA. [Kasckow, John] Univ Pittsburgh, Western Psychiat Inst & Clin, Med Ctr, Pittsburgh, PA 15213 USA. [Golshan, Shahrokh; Zisook, Sidney] VA San Diego Hlth Care Syst, San Diego, CA USA. [Golshan, Shahrokh; Zisook, Sidney] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. RP Kasckow, J (reprint author), VA Pittsburgh Hlth Care Syst, Behav Hlth, Univ Dr, Pittsburgh, PA 15240 USA. EM kasckowjw@upmc.edu FU VA HSRD [PPO 10-249-2]; VISN [4, 22 MIRECC]; University of California, San Diego Center for Community-Based Research in Older People with Psychoses; Cincinnati VAMC; University of Cincinnati College of Medicine; PamLab; Astra Zeneca; [MH6398] FX This work was supported by MH6398 (SZ and JK), VA HSRD PPO 10-249-2 (JK), the VISN 4 and VISN 22 MIRECC, and the University of California, San Diego Center for Community-Based Research in Older People with Psychoses. The authors thank the Cincinnati VAMC and the University of Cincinnati College of Medicine for support. The contents of this article do not represent the views of the US government or the Department of Veterans Affairs of the US government. SZ has received research support from PamLab, and JK has received research support from Astra Zeneca. NR 10 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD MAY PY 2014 VL 22 IS 5 BP 437 EP 441 DI 10.1016/j.jagp.2013.01.039 PG 5 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA AH4HE UT WOS:000336087200003 PM 23567374 ER PT J AU McDaniel, SH Grus, CL Cubic, BA Hunter, CL Kearney, LK Schuman, CC Karel, MJ Kessler, RS Larkin, KT McCutcheon, S Miller, BF Nash, J Qualls, SH Connolly, KS Stancin, T Stanton, AL Sturm, LA Johnson, SB AF McDaniel, Susan H. Grus, Catherine L. Cubic, Barbara A. Hunter, Christopher L. Kearney, Lisa K. Schuman, Catherine C. Karel, Michele J. Kessler, Rodger S. Larkin, Kevin T. McCutcheon, Stephen Miller, Benjamin F. Nash, Justin Qualls, Sara H. Connolly, Kathryn Sanders Stancin, Terry Stanton, Annette L. Sturm, Lynne A. Johnson, Suzanne Bennett TI Competencies for Psychology Practice in Primary Care SO AMERICAN PSYCHOLOGIST LA English DT Article DE primary care; competence; education and training ID CENTERED MEDICAL HOME; PROFESSIONAL PSYCHOLOGY; BEHAVIORAL HEALTH; POPULATION HEALTH; MODEL; EDUCATION; PROJECT; GEROPSYCHOLOGY; BENCHMARKS; SERVICES AB This article reports on the outcome of a presidential initiative of 2012 American Psychological Association President Suzanne Bennett Johnson to delineate competencies for primary care (PC) psychology in six broad domains: science, systems, professionalism, relationships, application, and education. Essential knowledge, skills, and attitudes are described for each PC psychology competency. Two behavioral examples are provided to illustrate each competency. Clinical vignettes demonstrate the competencies in action. Delineation of these competencies is intended to inform education, practice, and research in PC psychology and efforts to further develop team-based competencies in PC. C1 [McDaniel, Susan H.] Univ Rochester, Med Ctr, Inst Family, Dept Psychiat, Rochester, NY 14620 USA. [McDaniel, Susan H.] Univ Rochester, Med Ctr, Dept Family Med, Rochester, NY 14620 USA. [Grus, Catherine L.] Amer Psychol Assoc, Educ Directorate, Washington, DC 20036 USA. [Cubic, Barbara A.] Eastern Virginia Med Sch, Dept Family Med, Norfolk, VA USA. [Hunter, Christopher L.] Def Hlth Agcy, Patient Ctr Med Home Branch, Clin Support Div, Falls Church, VA USA. [Kearney, Lisa K.] Vet Hlth Adm, Off Mental Hlth Operat, Dept Vet Affairs, Cent Off, Washington, DC USA. [Kearney, Lisa K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA. [Schuman, Catherine C.] Harvard Univ, Sch Med, Dept Psychiat, Div Psychol, Cambridge, MA 02138 USA. [Karel, Michele J.] Dept Vet Affairs, Off Mental Hlth Serv, Cent Off, Washington, DC USA. [Kessler, Rodger S.] Vermont Coll Med, Dept Family Med, Burlington, VT USA. [Larkin, Kevin T.] W Virginia Univ, Dept Psychol, Morgantown, WV 26506 USA. [McCutcheon, Stephen] Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. [Miller, Benjamin F.] Univ Colorado Denver, Sch Med, Dept Family Med, Denver, CO USA. [Nash, Justin] Brown Univ, Dept Family Med, Pawtucket, RI USA. [Nash, Justin] Brown Univ, Mem Hosp Rhode Isl, Pawtucket, RI 02860 USA. [Qualls, Sara H.] Univ Colorado, Dept Psychol, Colorado Springs, CO 80933 USA. [Connolly, Kathryn Sanders] Vet Affairs Connecticut Healthcare Syst, Psychol Serv, West Haven, CT USA. [Connolly, Kathryn Sanders] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA. [Stancin, Terry] MetroHlth Med Ctr, Div Child & Adolescent Psychiat & Psychol, Cleveland, OH USA. [Stancin, Terry] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA. [Stanton, Annette L.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA. [Sturm, Lynne A.] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA. [Johnson, Suzanne Bennett] Florida State Univ, Coll Med, Dept Med Humanities & Social Sci, Tallahassee, FL 32306 USA. RP McDaniel, SH (reprint author), Univ Rochester, Med Ctr, Dept Family Med, 777 S Clinton Ave, Rochester, NY 14620 USA. EM susanh2_mcdaniel@urmc.rochester.edu OI Miller, Benjamin/0000-0003-1647-0122 NR 71 TC 36 Z9 36 U1 2 U2 15 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0003-066X EI 1935-990X J9 AM PSYCHOL JI Am. Psychol. PD MAY-JUN PY 2014 VL 69 IS 4 SI SI BP 409 EP 429 DI 10.1037/a0036072 PG 21 WC Psychology, Multidisciplinary SC Psychology GA AH5ER UT WOS:000336151800009 PM 24820690 ER PT J AU Williams, BA Schott, NJ Mangione, MP Ibinson, JW AF Williams, Brian A. Schott, Nicholas J. Mangione, Michael P. Ibinson, James W. TI Perineural Dexamethasone and Multimodal Perineural Analgesia: How Much Is Too Much? SO ANESTHESIA AND ANALGESIA LA English DT Editorial Material ID SCIATIC-NERVE BLOCK; ELIMINATING POSTOPERATIVE NAUSEA; OFF-PATENT ANTIEMETICS; OUTPATIENT SURGERY; LOCAL-ANESTHETICS; ROPIVACAINE; DURATION; RAT; DEXMEDETOMIDINE; METAANALYSIS C1 [Williams, Brian A.; Ibinson, James W.] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Vet Affairs Pittsburgh Healthcare Syst, Pittsburgh, PA 15261 USA. [Schott, Nicholas J.] UPMC, Dept Anesthesiol, Pittsburgh, PA USA. [Mangione, Michael P.] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA 15261 USA. RP Williams, BA (reprint author), Univ Pittsburgh, Sch Med, Dept Anesthesiol, Vet Affairs Pittsburgh Healthcare Syst, 200 Lothrop St,A-1305, Pittsburgh, PA 15261 USA. EM Williamsba@anes.upmc.edu NR 20 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 EI 1526-7598 J9 ANESTH ANALG JI Anesth. Analg. PD MAY PY 2014 VL 118 IS 5 BP 912 EP 914 DI 10.1213/ANE.0000000000000203 PG 3 WC Anesthesiology SC Anesthesiology GA AG4NE UT WOS:000335395900008 PM 24781562 ER PT J AU Kruse, JL Jeffrey, JK Davis, MC Dearlove, J IsHak, WW Brooks, JO AF Kruse, Jennifer L. Jeffrey, Jessica K. Davis, Michael C. Dearlove, Joanna IsHak, Waguih William Brooks, John O., III TI Anti-N-methyl-D-aspartate receptor encephalitis: A targeted review of clinical presentation, diagnosis, and approaches to psychopharmacologic management SO ANNALS OF CLINICAL PSYCHIATRY LA English DT Review DE N-methyl-D-aspartate receptor; limbic encephalitis; behavioral symptoms; benzodiazepines; antipsychotic agents ID NMDAR ENCEPHALITIS; ANTIBODIES; ADOLESCENTS; DISEASES; CHILDREN AB BACKGROUND: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis was formally described in 2007 and includes a range of psychiatric and neurologic symptoms. Most patients with anti-NMDAR encephalitis initially present to psychiatrists for diagnosis and treatment. However, there is limited literature summarizing treatment strategies for psychiatric symptoms. In an effort to improve identification and treatment, this review article provides an overview of anti-NMDAR encephalitis, with a focus on psychopharmacologic treatment strategies. Two case reports provide a clinical context for the literature review. METHODS: The authors conducted a PubMed search. RESULTS: Prominent psychiatric symptoms of anti-NMDAR encephalitis include psychosis, agitation, insomnia, and catatonia. Neuroleptics may be helpful for managing psychosis and agitation, but may exacerbate movement abnormalities. Diphenhydramine and benzodiazepines are helpful for agitation and insomnia. In addition, the anticholinergic affinity of diphenhydramine can improve dystonia or rigidity attributable to anti-NMDAR encephalitis, while benzodiazepines and electroconvulsive therapy have been used for catatonia associated with this condition. CONCLUSIONS: Psychiatrists play an important role in the diagnosis and treatment of anti-NMDAR encephalitis. Recognizing the typical clinical progression and closely monitoring for accompanying neurologic symptoms will facilitate diagnosis and timely treatment. Careful selection of psychopharmacological interventions may reduce suffering. C1 [Kruse, Jennifer L.; Jeffrey, Jessica K.; Davis, Michael C.; Brooks, John O., III] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Kruse, Jennifer L.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA. [Davis, Michael C.] VA Greater Los Angeles, Los Angeles, CA USA. [Dearlove, Joanna] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA. [IsHak, Waguih William] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Dept Psychiat & Behav Neurosci,Cedars Sinai Med C, Los Angeles, CA 90095 USA. RP Brooks, JO (reprint author), UCLA Semel Inst, 760 Westwood Plaza,B3-267, Los Angeles, CA 90024 USA. EM john.brooks@ucla.edu RI Davis, Michael/L-8920-2013 OI Davis, Michael/0000-0003-2293-5694 FU Pfizer FX Dr. Brooks has received a research grant from Pfizer, and is a speaker for Sunovion. Drs. Kruse, Jeffrey, Davis, Dearlove, and IsHak report no financial relationships with any company whose products are mentioned in this article or with manufacturers of competing products. NR 23 TC 15 Z9 16 U1 1 U2 5 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 1040-1237 EI 1547-3325 J9 ANN CLIN PSYCHIATRY JI Ann. Clin. Psychiatry PD MAY PY 2014 VL 26 IS 2 BP 111 EP 119 PG 9 WC Psychiatry SC Psychiatry GA AH7WX UT WOS:000336347200005 PM 24501734 ER PT J AU Uneyama, H Takeuchi, K Tache, YF AF Uneyama, Hisayuki Takeuchi, Koji Tache, Yvette F. TI Molecular Basis of Gastrointestinal Chemical Senses SO CURRENT PHARMACEUTICAL DESIGN LA English DT Editorial Material DE Taste; gut nutrient-sensing; gastrointestinal diseases ID GUT C1 [Uneyama, Hisayuki] Ajinomoto Co Inc, Inst Innovat, Frontier Res Labs, Umami Wellness Res Grp, Kawasaki, Kanagawa 2108681, Japan. [Takeuchi, Koji] Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Div Pathol Sci, Yamashina Ku, Kyoto 6078414, Japan. [Tache, Yvette F.] Univ Calif Los Angeles, CURE Digest Dis Res Ctr, Los Angeles, CA 90024 USA. [Tache, Yvette F.] Univ Calif Los Angeles, Ctr Neurobiol Stress, Vet Affairs Greater Los Angeles Healthcare Syst, Dept Med,Digest Dis Div, Los Angeles, CA 90024 USA. [Tache, Yvette F.] VA Greater Los Angeles Healght Care Syst, Los Angeles, CA USA. RP Uneyama, H (reprint author), Ajinomoto Co Inc, Inst Innovat, Frontier Res Labs, Umami Wellness Res Grp, 1-1 Suzuki Cho, Kawasaki, Kanagawa 2108681, Japan. EM hisayuki_uneyama@ajinomoto.com NR 21 TC 0 Z9 0 U1 1 U2 2 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1381-6128 EI 1873-4286 J9 CURR PHARM DESIGN JI Curr. Pharm. Design PD MAY PY 2014 VL 20 IS 16 BP 2667 EP 2668 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AH5NB UT WOS:000336175700001 PM 24828701 ER PT J AU Tache, Y Adelson, D Yang, H AF Tache, Yvette Adelson, David Yang, Hong TI TRH/TRH-R1 Receptor Signaling in the Brain Medulla as a Pathway of Vagally Mediated Gut Responses During the Cephalic Phase SO CURRENT PHARMACEUTICAL DESIGN LA English DT Article DE Dorsal vagal complex; enteric nervous system; gastric secretion; TRH; sham feeding and vagus ID THYROTROPIN-RELEASING-HORMONE; GASTRIC-ACID-SECRETION; DORSAL MOTOR NUCLEUS; RAPHE PALLIDUS NEURONS; CENTRAL-NERVOUS-SYSTEM; SUBSTANCE-P; NUTRITIONAL IMPLICATIONS; INTRACISTERNAL TRH; STABILIZED ANALOG; MYENTERIC NEURONS AB Pavlov's seminal findings in the early twentieth century showed that the sight, smell or taste of food in dogs with chronic esophagostomy induces a vagal-dependent gastric acid secretion. These observations established the concept of the cephalic phase of digestion. Compelling experimental evidence in rats indicates that the three amino acid peptide thyrotropin-releasing hormone (TRH) expressed in the brainstem plays a key role in the vagal stimulation of gastric function. Neurons in the dorsal motor nucleus of the vagus (DMN) expressed TRH receptor subtype (TRH-R1) and received efferent input from TRH containing fibers arising from TRH synthesizing neurons in the raphe pallidus, raphe obscurus, and the parapyramidal regions. TRH microinjected into the DMN or intracisternally excites the firing of DMN neurons and stimulates efferent activity in the gastric branch of the vagus nerve and gastric myenteric cholinergic neurons. At the functional level, this results in a vagally-mediated and atropine-sensitive stimulation of gastric epithelial and endocrine cells secreting acid, pepsin, serotonin, histamine and ghrelin, and enteric neurons leading to increased gastric motility and emptying. Importantly, the blockade of TRH or TRH-R1 in the brainstem by pretreatment into the cisterna magna or the DMN with TRH antibody or TRH-R1 oligodeoxynucleotide antisense respectively abolishes the stimulation of gastric acid induced by sham-feeding. The gastric response to TRH injected into the DMN is potentiated by serotonin and the proTRH flanking peptide, Ps4 and suppressed by a number of brainstem peptides and cytokines activated during stress or immune response and inhibiting food intake and gastric acid secretion. These convergent data strongly support a physiological involvement of TRH signaling pathway in the brainstem to stimulate vagal activity and identified TRH-TRH-R1 system as a major effector in the dorsal vagal complex to drive the vagally mediated gut response triggered by the cephalic phase. C1 Univ Calif Los Angeles, CURE Digest Dis Res Ctr David Geffen Sch, Los Angeles, CA 90073 USA. Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Ctr Neurobiol Stress,Dept Med,Digest Dis Div, Los Angeles, CA 90073 USA. VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. RP Tache, Y (reprint author), VA Greater Los Angeles Healthcare Syst, CURE DDRC, Bldg 115,Rm 117,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM ytache@mednet.ucla.edu OI Adelson, David/0000-0002-4623-6030 FU NIHDDK [DK 33061]; Center (Animal Core) [DK 41301] FX The authors' work was supported by the NIHDDK grant DK 33061, the Center grant DK 41301 (Animal Core), VA Merit Award and VA Research Career Scientist Award. We thank Eugenia Hu for helping in the preparation of to the manuscript. NR 102 TC 7 Z9 7 U1 0 U2 4 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1381-6128 EI 1873-4286 J9 CURR PHARM DESIGN JI Curr. Pharm. Design PD MAY PY 2014 VL 20 IS 16 BP 2725 EP 2730 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AH5NB UT WOS:000336175700007 PM 23886382 ER PT J AU Akiba, Y Kaunitz, JD AF Akiba, Yasutada Kaunitz, Jonathan D. TI Duodenal Luminal Chemosensing; Acid, ATP, and Nutrients SO CURRENT PHARMACEUTICAL DESIGN LA English DT Article DE Luminal nutrient; G-protein coupled receptors and gut hormone release ID PROTEIN-COUPLED RECEPTOR; DIPEPTIDYL-PEPTIDASE-IV; GLUCAGON-LIKE PEPTIDE-2; BICARBONATE SECRETION; RAT DUODENUM; GASTROINTESTINAL-TRACT; TASTE RECEPTORS; HCO3-SECRETION; CARBONIC-ANHYDRASES; CALCIUM-ABSORPTION AB Intestinal chemosensing of endogenous and exogenous luminal compounds, including acid, CO2, bile acids and nutrients is an emerging area of gastrointestinal research, since gut hormones, particularly including incretins and glucagon-like peptide-2 (GLP-2) are released in response to luminal nutrients. Identification of luminal chemosensors such as nutrient-ligand G-protein coupled receptors (GPCRs) in enteroendocrine cells has linked luminal compounds to the corresponding gut hormone release. Mucosal chemical sensors are necessary to exert physiological responses such as secretion, digestion, absorption, and motility. We have been studying the mechanisms by which luminal compounds are sensed via mucosal acid sensors and GPCRs, which trigger mucosal defense mechanisms. In addition to luminal acid/CO2 sensing in the duodenum, recent studies also show that compounds present post-prandially such as amino acids, bile acids and fatty acids, enhance duodenal mucosal defenses, with digestion following the initial gastric processing. These studies may form the basis for therapies in which luminal nutrients release gut hormones that affect the mucosal protection, appetite, satiety, and systemic metabolisms. C1 Univ Calif Los Angeles, Sch Med, Dept Med, Vet Affairs Greater Los Angles Healthcare Syst, Los Angeles, CA 90073 USA. Brentwood Biomed Res Inst, Los Angeles, CA 90073 USA. RP Akiba, Y (reprint author), West Los Angeles VA Med Ctr, Bldg 114,Suite 217,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM yakiba@mednet.ucla.edu FU Ajinomoto Inc., Japan; AstraZeneca [IRUSESOM0424]; Department of Veterans Affairs Merit Review Award; NIH-NIDDK [R01 DK54221] FX Supported by a research grant from Ajinomoto Inc., Japan (Y. Akiba), Investigator-Sponsored Study Program of AstraZeneca IRUSESOM0424 (Y. Akiba), Department of Veterans Affairs Merit Review Award (J. Kaunitz), and NIH-NIDDK R01 DK54221 (J. Kaunitz). NR 65 TC 7 Z9 7 U1 2 U2 6 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1381-6128 EI 1873-4286 J9 CURR PHARM DESIGN JI Curr. Pharm. Design PD MAY PY 2014 VL 20 IS 16 BP 2760 EP 2765 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AH5NB UT WOS:000336175700013 PM 23886391 ER PT J AU Chen, WL Walwyn, W Ennes, HS Kim, H McRoberts, JA Marvizon, JCG AF Chen, Wenling Walwyn, Wendy Ennes, Helena S. Kim, Hyeyoung McRoberts, James A. Marvizon, Juan Carlos G. TI BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE microglia; mouse; neurokinin 1 receptor; rat; substance P; trkB receptor ID RAT SPINAL-CORD; DORSAL-ROOT GANGLIA; SUBSTANCE-P RELEASE; PRIMARY SENSORY NEURONS; D-ASPARTATE RECEPTORS; SRC FAMILY KINASES; NEUROTROPHIC FACTOR; MEDIATED PHOSPHORYLATION; NEUROKININ-1 RECEPTOR; SYNAPTIC-TRANSMISSION AB NMDA receptors in primary afferent terminals can contribute to hyperalgesia by increasing neurotransmitter release. In rats and mice, we found that the ability of intrathecal NMDA to induce neurokinin 1 receptor (NK1R) internalization (a measure of substanceP release) required a previous injection of BDNF. Selective knock-down of NMDA receptors in primary afferents decreased NMDA-induced NK1R internalization, confirming the presynaptic location of these receptors. The effect of BDNF was mediated by tropomyosin-related kinaseB (trkB) receptors and not p75 neurotrophin receptors (p75(NTR)), because it was not produced by proBDNF and was inhibited by the trkB antagonist ANA-12 but not by the p75(NTR) inhibitor TAT-Pep5. These effects are probably mediated through the truncated form of the trkB receptor as there is little expression of full-length trkB in dorsal root ganglion (DRG) neurons. Src family kinase inhibitors blocked the effect of BDNF, suggesting that trkB receptors promote the activation of these NMDA receptors by Src family kinase phosphorylation. Western blots of cultured DRG neurons revealed that BDNF increased Tyr(1472) phosphorylation of the NR2B subunit of the NMDA receptor, known to have a potentiating effect. Patch-clamp recordings showed that BDNF, but not proBDNF, increased NMDA receptor currents in cultured DRG neurons. NMDA-induced NK1R internalization was also enabled in a neuropathic pain model or by activating dorsal horn microglia with lipopolysaccharide. These effects were decreased by a BDNF scavenger, a trkB receptor antagonist and a Src family kinase inhibitor, indicating that BDNF released by microglia potentiates NMDA receptors in primary afferents during neuropathic pain. C1 [Chen, Wenling; McRoberts, James A.; Marvizon, Juan Carlos G.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. [Chen, Wenling; Ennes, Helena S.; Kim, Hyeyoung; McRoberts, James A.; Marvizon, Juan Carlos G.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Digest Dis, Los Angeles, CA 90095 USA. [Walwyn, Wendy] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA. RP Marvizon, JCG (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. EM marvizon@ucla.edu FU National Institute of Drug Abuse [R01-DA033059]; Rehabilitation Research & Development Service, Department of Veterans Affairs [1I01RX000378]; Division of Digestive Diseases at the David Geffen School of Medicine, UCLA; NIH [1S10RR028124] FX Supported by grant R01-DA033059 to J.C.M and J.A.M. from the National Institute of Drug Abuse, grant 1I01RX000378 to J.C.M. from the Rehabilitation Research & Development Service, Department of Veterans Affairs and research funds from the Division of Digestive Diseases at the David Geffen School of Medicine, UCLA. Mutant mice were provided by the UCLA Behavioral Core by under the direction of Michael Fanselow and supported by NIH grant 1S10RR028124. This study was done under the umbrella of the following UCLA institutes: Brain Research Institute, Center for the Study of Opioid Receptors and Drugs of Abuse, CURE: Digestive Diseases Research Center and the Oppenheimer Family Center for Neurobiology of Stress. The authors declare no competing financial interests. NR 83 TC 14 Z9 14 U1 1 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0953-816X EI 1460-9568 J9 EUR J NEUROSCI JI Eur. J. Neurosci. PD MAY PY 2014 VL 39 IS 9 BP 1439 EP 1454 DI 10.1111/ejn.12516 PG 16 WC Neurosciences SC Neurosciences & Neurology GA AG1ZP UT WOS:000335215000005 PM 24611998 ER PT J AU Sanfilippo, KM McTigue, KM Fidler, CJ Neaton, JD Chang, YF Fried, LF Liu, SM Kuller, LH AF Sanfilippo, Kristen M. McTigue, Kathleen M. Fidler, Christian J. Neaton, James D. Chang, Yuefang Fried, Linda F. Liu, Simin Kuller, Lewis H. TI Hypertension and Obesity and the Risk of Kidney Cancer in 2 Large Cohorts of US Men and Women SO HYPERTENSION LA English DT Article DE blood pressure; body weight; epidemiology; kidney neoplasms; obesity ID RENAL-CELL CARCINOMA; HIPPEL-LINDAU GENE; BLOOD-PRESSURE; ANTIHYPERTENSIVE MEDICATION; POSTMENOPAUSAL WOMEN; LIPID-PEROXIDATION; CIGARETTE-SMOKING; UNITED-STATES; MECHANISMS; ASCERTAINMENT AB Kidney cancer incidence is increasing globally. Reasons for this rise are unclear but could relate to obesity and hypertension. We analyzed longitudinal relationships between hypertension and obesity and kidney cancer incidence in 156 774 participants of the Women's Health Initiative clinical trials and observational studies over 10.8 years. In addition, we examined the effect of blood pressure (BP) on kidney cancer deaths for over 25 years among the 353 340 men screened for the Multiple Risk Factor Intervention Trial (MRFIT). In the Women's Health Initiative, systolic BP (SBP) was categorized in 6 groups from <120 to >160 mm Hg, and body mass index was categorized using standard criteria. In age-adjusted analyses, kidney cancer risk increased across SBP categories (P value for trend <0.0001) and body mass index categories (P value for trend <0.0001). In adjusted Cox proportional hazards models, both SBP levels and body mass index were predictors of kidney cancer. In the MRFIT sample, there were 906 deaths after an average of 25 years of follow-up attributed to kidney cancer among the 353 340 participants aged 35 to 57 years at screening. The risk of death from kidney cancer increased in a dose-response fashion with increasing SBP (hazard ratio, 1.87 for SBP>160 versus <120 mm Hg; 95% confidence interval, 1.38-2.53). Risk was increased among cigarette smokers. Further research is needed to determine the pathophysiologic basis of relationships between both higher BP and the risk of kidney cancer, and whether specific drug therapies for hypertension can reduce kidney cancer risk. C1 [Sanfilippo, Kristen M.] Washington Univ, Dept Hematol, St Louis, MO USA. [Sanfilippo, Kristen M.] VA St Louis Healthcare Syst, Res Serv, St Louis, MO USA. [McTigue, Kathleen M.; Fried, Linda F.] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15260 USA. [Chang, Yuefang] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [McTigue, Kathleen M.; Fried, Linda F.; Kuller, Lewis H.] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA. [Fidler, Christian J.] Abington Mem Hosp, Rosenfeld Canc Ctr, Abington, PA 19001 USA. [Neaton, James D.] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA. [Fried, Linda F.] VA Pittsburgh Healthcare Syst, Dept Peritoneal Dialysis, Pittsburgh, PA USA. [Liu, Simin] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA. RP McTigue, KM (reprint author), Univ Pittsburgh, Dept Med & Epidemiol, 230 McKee Pl Suite 600, Pittsburgh, PA 15213 USA. EM kmm34@pitt.edu RI Liu, Simin/I-3689-2014 OI Liu, Simin/0000-0003-2098-3844 FU Women's Health Initiative (WHI); National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health (NIH); US Department of Health and Human Services [HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C]; University of Pittsburgh Internal Medicine Residency program; NHLBI, NIH, Bethesda, MD; NIH/NHLBI [R01-HL-43232, R01-HL-68140] FX The Women's Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), US Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. Dr Sanfilippo's time on this project was supported by the University of Pittsburgh Internal Medicine Residency program. The Multiple Risk Factor Intervention Trial was contracted by the NHLBI, NIH, Bethesda, MD. Followup after the end of the trial was supported with NIH/NHLBI grants -R01-HL-43232 and R01-HL-68140. NR 35 TC 9 Z9 10 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0194-911X EI 1524-4563 J9 HYPERTENSION JI Hypertension PD MAY PY 2014 VL 63 IS 5 BP 934 EP 941 DI 10.1161/HYPERTENSIONAHA.113.02953 PG 8 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AE9IG UT WOS:000334320900021 PM 24637660 ER PT J AU Hanson, L VandeVusse, L Duster, M Warrack, S Safdar, N AF Hanson, Lisa VandeVusse, Leona Duster, Megan Warrack, Simone Safdar, Nasia TI Feasibility of Oral Prenatal Probiotics against Maternal Group B Streptococcus Vaginal and Rectal Colonization SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Article DE pregnancy; probiotics; group B Streptococcus ID PATIENT PREFERENCE; ANTIBIOTICS; INFECTIONS; WOMEN; RISK; LACTOBACILLI; PROPHYLAXIS; EXPOSURE; EFFICACY; OUTCOMES AB ObjectiveTo examine the effect of an oral prenatal probiotic on group B Streptococcus (GBS) colonization and to demonstrate the feasibility of a larger randomized controlled trial. DesignThis pilot study was an open-label, two-group quasi-experiment. SettingAn urban central city nurse-midwifery and wellness center serving a diverse population. ParticipantsTen pregnant participants received the oral probiotic (Florajen3) taken once daily, and 10 participants served as controls. MethodsA questionnaire on dietary practices, vaginal cleansing, sexual history, and symptoms and GBS colony count samples were taken at 28-, 32-, and 36-weeks gestation. ResultsParticipants in the probiotic group reported no adverse events or minor side effects; one half reported improved gastrointestinal symptoms. Although two women in each group had positive qualitative prenatal GBS cultures at 36weeks, the probiotic group participants had lower quantitative GBS colony counts. The eight GBS negative averaged 90% probiotic adherence compared with two GBS positive women who averaged 68%. Yogurt ingestion was inversely related (p=.02) to GBS colonization. ConclusionsPrenatal probiotic therapy has the potential to reduce GBS colonization. The potential of the probiotic intervention appears to be linked to daily adherence. A controlled clinical trial with a larger, adequately powered sample is feasible and justified. C1 [Hanson, Lisa; VandeVusse, Leona] Marquette Univ, Coll Nursing, Nurse Midwifery Program, Milwaukee, WI 53201 USA. [Hanson, Lisa] Aurora Sinai Midwifery & Wellness Ctr, Milwaukee, WI USA. [Duster, Megan] Univ Wisconsin, Sch Med & Publ Hlth, Infect Dis Res Lab, Div Infect Dis, Madison, WI USA. [Warrack, Simone] Univ Wisconsin, Sch Med & Publ Hlth, Infect Dis Res Lab, Madison, WI USA. [Safdar, Nasia] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med & Infect Dis, Madison, WI USA. [Safdar, Nasia] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. RP Hanson, L (reprint author), Marquette Univ, Coll Nursing, Clark Hall 341,POB 1881, Milwaukee, WI 53201 USA. EM lisa.hanson@mu.edu FU American Lifeline Inc. FX Funded by an unrestricted research grant from American Lifeline Inc. NR 37 TC 7 Z9 7 U1 2 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0884-2175 EI 1552-6909 J9 JOGNN-J OBST GYN NEO JI JOGNN PD MAY PY 2014 VL 43 IS 3 BP 294 EP 304 DI 10.1111/1552-6909.12308 PG 11 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA AH0SB UT WOS:000335829500007 PM 24754328 ER PT J AU Stefan, M Zhang, WJ Concepcion, E Yi, ZZ Tomer, Y AF Stefan, Mihaela Zhang, Weijia Concepcion, Erlinda Yi, Zhengzi Tomer, Yaron TI DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology SO JOURNAL OF AUTOIMMUNITY LA English DT Article DE Type I diabetes; DNA methylation; Monozygotic twins; Transcriptional regulation ID RHEUMATOID-ARTHRITIS; MELLITUS; PROMOTER AB Type 1 diabetes (T1D) shows similar to 40% concordance rate in monozygotic twins (MZ) suggesting a role for environmental factors and/or epigenetic modifications in the etiology of the disease. The aim of our study was to dissect the contribution of epigenetic factors, particularly, DNA methylation (DNAm), to the incomplete penetrance of T1D. We performed DNAm profiling in lymphocyte cell lines from 3 monozygotic (MZ) twin pairs discordant for T1D and 6 MZ twin pairs concordant for the disease using HumanMethylation27 BeadChip. This assay assesses the methylation state of 27,578 CpG sites, mostly located within proximal promoter regions. We identified 88 CpG sites displaying significant methylation changes in all T1D-discordant MZ twin pairs. Functional annotation of the genes with distinct CpG methylation profiles in T1D samples showed differential DNAm of immune response and defense response pathways between affected and unaffected twins. Integration of DNAm data with GWAS data mapped several known T1D associated genes, HLA, INS, IL-2RB, CD226, which showed significant differences in DNAm between affected and unaffected of twins. Our findings suggest that abnormalities of DNA methylation patterns, known to regulate gene transcription, may be involved in the pathogenesis of TI D. Published by Elsevier Ltd. C1 [Stefan, Mihaela; Concepcion, Erlinda; Tomer, Yaron] Mt Sinai Sch Med, Div Endocrinol, New York, NY 10029 USA. [Zhang, Weijia; Yi, Zhengzi] Mt Sinai Sch Med, Dept Med, Bioinformat Core, New York, NY 10029 USA. [Stefan, Mihaela; Tomer, Yaron] James J Peters Vet Adm Med Ctr, Bronx, NY 10468 USA. RP Tomer, Y (reprint author), Mt Sinai Med Ctr, Div Endocrinol, Box 1055,One Gustave L Levy Pl, New York, NY 10029 USA. EM Yaron.Tomer@mssm.edu FU NIDDK [DK061659, DK067555 82, DK073681]; Department of Veterans Affairs,Veterans Health Administration, Office of Research and Development; VA Biomedical Laboratory Research and Development Merit Award [1I01BX002031] FX We thank the National Disease Research Interchange (NDRI, Philadelphia, PA) for providing us with the DNA samples of the diabetes twins. This work was supported in part by grants DK061659, DK067555 82 DK073681 from NIDDK (to YT). In addition this material is based upon work supported in part by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and by the VA Biomedical Laboratory Research and Development Merit Award 1I01BX002031 (to YT). NR 22 TC 38 Z9 42 U1 1 U2 21 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0896-8411 EI 1095-9157 J9 J AUTOIMMUN JI J. Autoimmun. PD MAY PY 2014 VL 50 BP 33 EP 37 DI 10.1016/j.jaut.2013.10.001 PG 5 WC Immunology SC Immunology GA AH4RB UT WOS:000336114600004 PM 24210274 ER PT J AU Todoran, TM Basile, JN Zile, MR AF Todoran, Thomas M. Basile, Jan N. Zile, Michael R. TI Renal Sympathetic Denervation for Blood Pressure Control: A Review of the Current Evidence and Ongoing Studies SO JOURNAL OF CLINICAL HYPERTENSION LA English DT Editorial Material ID DRUG-RESISTANT HYPERTENSION; AMERICAN-HEART-ASSOCIATION; GLOBAL SYMPLICITY REGISTRY; ARTERY DENERVATION; NERVOUS-SYSTEM; TRIAL; CATHETER; ULTRASOUND; RATIONALE; STATEMENT AB Few randomized trials have compared visit-to-visit variability (VVV) of systolic blood pressure (SBP) across drug classes. The authors compared VVV of SBP among 24,004 participants randomized to chlorthalidone, amlodipine, or lisinopril in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). VVV of SBP was calculated across 5 to 7 visits occurring 6 to 28months following randomization. The standard deviation (SD) of SBP was 10.6 (SD=5.0), 10.5 (SD=4.9), and 12.2 (SD=5.8) for participants randomized to chlorthalidone, amlodipine, and lisinopril, respectively. After multivariable adjustment including mean SBP across visits and compared with participants randomized to chlorthalidone, participants randomized to amlodipine had a 0.36 (standard error [SE]: 0.07) lower SD of SBP and participants randomized to lisinopril had a 0.77 (SE=0.08) higher SD of SBP. Results were consistent using other VVV of SBP metrics. These data suggest chlorthalidone and amlodipine are associated with lower VVV of SBP than lisinopril. C1 [Todoran, Thomas M.; Basile, Jan N.; Zile, Michael R.] Med Univ S Carolina, Div Cardiol, Charleston, SC 29425 USA. [Todoran, Thomas M.; Basile, Jan N.; Zile, Michael R.] Vet Affairs Med Ctr, Ralph H Johnson Dept, Charleston, SC 29403 USA. RP Todoran, TM (reprint author), 25 Courtenay Dr MSC 592, Charleston, SC 29425 USA. EM todoran@musc.edu NR 33 TC 4 Z9 4 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1524-6175 EI 1751-7176 J9 J CLIN HYPERTENS JI J. Clin. Hypertens. PD MAY PY 2014 VL 16 IS 5 BP 331 EP 341 DI 10.1111/jch.12290 PG 11 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AH0IL UT WOS:000335802500004 PM 24655555 ER PT J AU Eng, JA Steinman, MA AF Eng, Jessica A. Steinman, Michael A. TI Changing Chronic Medications in Hospitalized Patients-Bridging the Inpatient-Outpatient Divide SO JOURNAL OF HOSPITAL MEDICINE LA English DT Editorial Material ID DECISION-MAKING; DISCHARGE C1 Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94143 USA. [Eng, Jessica A.] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. RP Eng, JA (reprint author), San Francisco VA Med Ctr, 4150 Clement St,181G, San Francisco, CA 94121 USA. EM jessica.eng@ucsf.edu FU NIA NIH HHS [P30 AG044281, K23 AG030999, 1K23-AG030999] NR 6 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1553-5592 EI 1553-5606 J9 J HOSP MED JI J. Hosp. Med. PD MAY PY 2014 VL 9 IS 5 BP 332 EP 333 DI 10.1002/jhm.2172 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AG8JI UT WOS:000335664200011 PM 24616285 ER PT J AU Han, XS Li, R Zhang, WB Yang, XH Wheeler, CG Friedman, GK Province, P Ding, Q You, ZY Fathallah-Shaykh, HM Gillespie, GY Zhao, XY King, PH Nabors, LB AF Han, Xiaosi Li, Rong Zhang, Wenbin Yang, Xiuhua Wheeler, Crystal G. Friedman, Gregory K. Province, Paula Ding, Qiang You, Zhiying Fathallah-Shaykh, Hassan M. Gillespie, G. Yancey Zhao, Xinyang King, Peter H. Nabors, L. Burt TI Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro SO JOURNAL OF NEURO-ONCOLOGY LA English DT Article DE Diffuse astrocytoma; Anaplastic astrocytoma; Glioblastoma; PRMT5; ERK1/2 ID PROTEIN ARGININE METHYLTRANSFERASE; CANCER CELLS; GERM-CELLS; METHYLATION; ACTIVATION; HISTONE; DIFFERENTIATION; GLIOBLASTOMA; DIMETHYLARGININE; TRANSCRIPTION AB Protein arginine methyltransferase 5 (PRMT5) catalyzes the formation of omega-NG,N'G-symmetric dimethylarginine residues on histones as well as other proteins. These modifications play an important role in cell differentiation and tumor cell growth. However, the role of PRMT5 in human glioma cells has not been characterized. In this study, we assessed protein expression profiles of PRMT5 in control brain, WHO grade II astrocytomas, anaplastic astrocytomas, and glioblastoma multiforme (GBM) by immunohistochemistry. PRMT5 was low in glial cells in control brain tissues and low grade astrocytomas. Its expression increased in parallel with malignant progression, and was highly expressed in GBM. Knockdown of PRMT5 by small hairpin RNA caused alterations of p-ERK1/2 and significantly repressed the clonogenic potential and viability of glioma cells. These findings indicate that PRMT5 is a marker of malignant progression in glioma tumors and plays a pivotal role in tumor growth. C1 [Han, Xiaosi; Zhang, Wenbin; Yang, Xiuhua; Wheeler, Crystal G.; Province, Paula; Fathallah-Shaykh, Hassan M.; King, Peter H.; Nabors, L. Burt] Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35294 USA. [Han, Xiaosi; King, Peter H.] Birmingham Vet Affairs Med Ctr, Birmingham, AL 35295 USA. [Li, Rong] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Friedman, Gregory K.] Univ Alabama Birmingham, Dept Pediat, Div Hematol Oncol, Birmingham, AL 35294 USA. [Ding, Qiang] Univ Alabama Birmingham, Div Pulm Med, Dept Med, Birmingham, AL 35294 USA. [You, Zhiying] Univ Alabama Birmingham, Dept Prevent Med, Birmingham, AL 35294 USA. [Gillespie, G. Yancey] Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL 35294 USA. [Zhao, Xinyang] Univ Alabama Birmingham, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA. RP Han, XS (reprint author), Univ Alabama Birmingham, Dept Neurol, FOT 1020,1530 3rd Ave S, Birmingham, AL 35294 USA. EM xhan@uab.edu OI Friedman, Gregory/0000-0002-6653-7420; Zhao, Xinyang/0000-0001-6677-7072 FU NIH NCI [P30CA013148, P50CA097247, P20CA151129]; St. Baldrick's Foundation; VA Merit Review FX NIH NCI Grants P30CA013148 (UAB Comprehensive Cancer Center Core Support Grant); P50CA097247, P20CA151129 (G. Y. Gillespie); St. Baldrick's Foundation (G. K. Friedman); VA Merit Review (P. H. King). NR 42 TC 14 Z9 15 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0167-594X EI 1573-7373 J9 J NEURO-ONCOL JI J. Neuro-Oncol. PD MAY PY 2014 VL 118 IS 1 BP 61 EP 72 DI 10.1007/s11060-014-1419-0 PG 12 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA AH8HC UT WOS:000336376700007 PM 24664369 ER PT J AU Kelley, AS Langa, KM Smith, AK Cagle, J Ornstein, K Silveira, MJ Nicholas, L Covinsky, KE Ritchie, CS AF Kelley, Amy S. Langa, Kenneth M. Smith, Alexander K. Cagle, John Ornstein, Katherine Silveira, Maria J. Nicholas, Lauren Covinsky, Kenneth E. Ritchie, Christine S. TI Leveraging the Health and Retirement Study To Advance Palliative Care Research SO JOURNAL OF PALLIATIVE MEDICINE LA English DT Article ID LAST 6 MONTHS; RESEARCH PRIORITIES; UNITED-STATES; SERIOUS ILLNESS; OLDER-ADULTS; LATER LIFE; NURSING-HOMES; DEMOGRAPHICS; DEMENTIA; MEMORY AB Background: The critical need to expand and develop the palliative care evidence base was recently highlighted by the Journal of Palliative Medicine's series of articles describing the Research Priorities in Geriatric Palliative Care. The Health and Retirement Study (HRS) is uniquely positioned to address many priority areas of palliative care research. This nationally representative, ongoing, longitudinal study collects detailed survey data every 2 years, including demographics, health and functional characteristics, information on family and caregivers, and personal finances, and also conducts a proxy interview after each subject's death. The HRS can also be linked with Medicare claims data and many other data sources, e.g., U.S. Census, Dartmouth Atlas of Health Care. Setting: While the HRS offers innumerable research opportunities, these data are complex and limitations do exist. Therefore, we assembled an interdisciplinary group of investigators using the HRS for palliative care research to identify the key palliative care research gaps that may be amenable to study within the HRS and the strengths and weaknesses of the HRS for each of these topic areas. Conclusion: In this article we present the work of this group as a potential roadmap for investigators contemplating the use of HRS data for palliative care research. C1 [Kelley, Amy S.; Ornstein, Katherine] Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, New York, NY 10029 USA. [Kelley, Amy S.] James J Peters VA Med Ctr, Geriatr Res Educ Ctr, Bronx, NY USA. [Kelley, Amy S.] James J Peters VA Med Ctr, Clin Ctr, Bronx, NY USA. [Langa, Kenneth M.; Silveira, Maria J.] Vet Adm Ann Arbor, Ctr Clin Mangement Res, Ann Arbor, MI USA. [Langa, Kenneth M.; Silveira, Maria J.] Univ Michigan, Div Gen Med, Ann Arbor, MI 48109 USA. [Langa, Kenneth M.; Nicholas, Lauren] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Langa, Kenneth M.] Univ Michigan, Inst Gerontol, Ann Arbor, MI 48109 USA. [Langa, Kenneth M.] Univ Michigan, Inst Healthcare Policy & Innovat, Ann Arbor, MI 48109 USA. [Smith, Alexander K.; Covinsky, Kenneth E.; Ritchie, Christine S.] Univ Calif San Francisco, Dept Med, Div Geriatr, San Francisco, CA USA. [Cagle, John] Univ Maryland, Sch Social Work, Baltimore, MD 21201 USA. RP Kelley, AS (reprint author), Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, 1 Gustave L Levy Pl,Box 1070, New York, NY 10029 USA. EM amy.kelley@mssm.edu FU National Palliative Care Research Center; Advanced Illness and Multimorbidity Geriatric Academic Leadership Award [1K07AG31779]; Improving Care for Older Adults with Serious Illness National Institute on Aging [1K23AG040774-01A1]; American Federation for Aging Research; National Institute on Aging [U01 AG009740]; Social Security Administration FX Funded by the National Palliative Care Research Center; Advanced Illness and Multimorbidity Geriatric Academic Leadership Award (1K07AG31779); Improving Care for Older Adults with Serious Illness National Institute on Aging (1K23AG040774-01A1); and the American Federation for Aging Research.; The Health and Retirement Study is funded by the National Institute on Aging (U01 AG009740) and the Social Security Administration, and is performed at the Institute for Social Research, University of Michigan. NR 40 TC 2 Z9 2 U1 2 U2 9 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-6218 EI 1557-7740 J9 J PALLIAT MED JI J. Palliat. Med. PD MAY 1 PY 2014 VL 17 IS 5 BP 506 EP 511 DI 10.1089/jpm.2013.0648 PG 6 WC Health Care Sciences & Services SC Health Care Sciences & Services GA AG7EV UT WOS:000335581800005 PM 24694096 ER PT J AU Lackey, AE Moshiri, M Pandey, T Lall, C Lalwani, N Bhargava, P AF Lackey, Amanda E. Moshiri, Mariam Pandey, Tarun Lall, Chandana Lalwani, Neeraj Bhargava, Puneet TI Productivity, Part 1: Getting Things Done, Using E-Mail, Scanners, Reference Managers, Note-taking Applications, and Text Expanders SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Article DE Productivity; workflow; time management AB In an era of declining reimbursements and tightening of the job market, today's radiologists are forced to "make do with less." With the rollout of the Patient Protection and Affordable Care Act, commonly called "Obamacare," radiologists will be expected not only to interpret studies but to also take on many additional roles, adding a new layer of complexity to already demanding daily duties. These changes make it more important than ever to develop a personal workflow management system incorporating some of the most potent productivity tools. In this article, the authors discuss current productivity techniques and related software with the most potential to help radiologists keep up with the ever increasing demands on their time at the work place and help us lead more balanced lives. C1 [Lackey, Amanda E.; Pandey, Tarun] Univ Arkansas Med Sci, Dept Radiol, Little Rock, AR 72205 USA. [Moshiri, Mariam; Lalwani, Neeraj] Univ Washington, Sch Med, Dept Radiol, Seattle, WA 98195 USA. [Lall, Chandana] Univ Calif Irvine, Orange, CA 92668 USA. [Bhargava, Puneet] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. [Bhargava, Puneet] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. RP Bhargava, P (reprint author), Univ Washington, Mail Box 358280,S-114 Radiol, Seattle, WA 98108 USA. EM bhargp@uw.edu RI Lalwani, Neeraj/A-3490-2011 OI Lalwani, Neeraj/0000-0001-5514-2805; Bhargava, Puneet/0000-0002-3849-9666 NR 24 TC 3 Z9 3 U1 4 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD MAY PY 2014 VL 11 IS 5 BP 481 EP 489 DI 10.1016/j.jacr.2013.11.020 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AH5TE UT WOS:000336193200012 PM 24656443 ER PT J AU Coca, SG Garg, AX Thiessen-Philbrook, H Koyner, JL Patel, UD Krumholz, HM Shlipak, MG Parikh, CR AF Coca, Steven G. Garg, Amit X. Thiessen-Philbrook, Heather Koyner, Jay L. Patel, Uptal D. Krumholz, Harlan M. Shlipak, Michael G. Parikh, Chirag R. CA TRIBE-AKI Consortium TI Urinary Biomarkers of AKI and Mortality 3 Years after Cardiac Surgery SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE KIDNEY INJURY; ACUTE-RENAL-FAILURE; PERITUBULAR CAPILLARIES; POOR OUTCOMES; DISEASE; RECLASSIFICATION; ASSOCIATION; PROTEINURIA; DAMAGE; RISK AB The endothelin system has emerged as a novel target for the treatment of diabetic nephropathy. Endothelin-1 promotes mesangial cell proliferation and sclerosis. However, no direct pathogenic effect of endothelin-1 on podocytes has been shown in vivo and endothelin-1 signaling in podocytes has not been investigated. This study investigated endothelin effects in podocytes during experimental diabetic nephropathy. Stimulation of primary mouse podocytes with endothelin-1 elicited rapid calcium transients mediated by endothelin type A receptors (ETARs) and endothelin type B receptors (ETBRs). We then generated mice with a podocyte-specific double deletion of ETAR and ETBR (NPHS2-CrexEdnra(lox/lox)xEdnrb(lox/lox) [Pod-ETRKO]). In vitro, treatment with endothelin-1 increased total beta-catenin and phospho-NF-kappa B expression in wild-type glomeruli, but this effect was attenuated in Pod-ETRKO glomeruli. After streptozotocin injection to induce diabetes, wild-type mice developed mild diabetic nephropathy with microalbuminuria, mesangial matrix expansion, glomerular basement membrane thickening, and podocyte loss, whereas Pod-ETRKO mice presented less albuminuria and were completely protected from glomerulosclerosis and podocyte loss, even when uninephrectomized. Moreover, glomeruli from normal and diabetic Pod-ETRKO mice expressed substantially less total beta-catenin and phospho-NF-kappa B compared with glomeruli from counterpart wild-type mice. This evidence suggests that endothelin-1 drives development of glomerulosclerosis and podocyte loss through direct activation of endothelin receptors and NF-kappa B and beta-catenin pathways in podocytes. Notably, both the expression and function of the ETBR subtype were found to be important. Furthermore, these results indicate that activation of the endothelin-1 pathways selectively in podocytes mediates pathophysiologic crosstalk that influences mesangial architecture and sclerosis. C1 [Coca, Steven G.; Parikh, Chirag R.] Yale Univ, Sch Med, Program Appl Translat Res, Sch Med,Vet Affairs Connecticut Healthcare Syst, New Haven, CT 06510 USA. [Garg, Amit X.; Thiessen-Philbrook, Heather] Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada. [Koyner, Jay L.] Univ Chicago, Dept Med, Nephrol Sect, Chicago, IL 60637 USA. [Patel, Uptal D.] Duke Univ, Sch Med, Duke Clin Res Inst, Durham, NC USA. [Krumholz, Harlan M.] Yale Univ, Ctr Outcomes Res & Evaluat, Yale New Haven Hosp, Sect Cardiovasc Med,Dept Internal Med,Sch Med, New Haven, CT 06510 USA. [Shlipak, Michael G.] Univ Calif San Francisco, Div Gen Internal Med, San Francisco Vet Affairs Med Ctr, San Francisco, CA 94143 USA. RP Parikh, CR (reprint author), Yale Univ, Sch Med, Nephrol Sect, 60 Temple Street,Suite 6C, New Haven, CT 06510 USA. EM chirag.parikh@yale.edu FU National Institutes of Health (NIH) [R01HL085757]; NIH [K23DK080132, K24DK090203, U01DK082185]; Ontario Ministry of Health and Long-Term Care FX The urine biomarker assays were donated by Abbott Diagnostics (IL-18 and NGAL) and Sekisui Diagnostics LLC (KIM-1 and L-FABP). This study was supported by the National Institutes of Health (NIH) (R01HL085757 to C.R.P.) to fund the TRIBE-AKI Consortium to study novel biomarkers of AKI in cardiac surgery. S.G.C. has been supported by an NIH Career Development Award (K23DK080132). C.R.P. is supported by the NIH (K24DK090203). S.G.C., A.X.G., and C.R.P. are also members of the NIH-sponsored Assess, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury Consortium (U01DK082185). The granting agencies, Abbott Diagnostics, and Sekisui Diagnostics, Inc. did not participate in the design and conduct of the study, collection, management, analysis, and interpretation of the data, and preparation, review, or approval of the manuscript. The Institute for Clinical Evaluative Sciences receives funding from the Ontario Ministry of Health and Long-Term Care. The opinions, results, and conclusions reported in this article are those of the authors and are independent from the funding sources. The results presented in this article have not been published previously in whole or part, except in abstract form. NR 27 TC 32 Z9 32 U1 2 U2 6 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 EI 1533-3450 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD MAY PY 2014 VL 25 IS 5 BP 1063 EP 1071 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA AG7FM UT WOS:000335583700024 PM 24357673 ER PT J AU Corbelli, J Borrero, S Bonnema, R McNamara, M Kraemer, K Rubio, D Karpov, I McNeil, M AF Corbelli, Jennifer Borrero, Sonya Bonnema, Rachel McNamara, Megan Kraemer, Kevin Rubio, Doris Karpov, Irina McNeil, Melissa TI Differences Among Primary Care Physicians' Adherence to 2009 ACOG Guidelines for Cervical Cancer Screening SO JOURNAL OF WOMENS HEALTH LA English DT Article ID BREAST-CANCER; HUMAN-PAPILLOMAVIRUS; WOMENS HEALTH; HEART-FAILURE; UNITED-STATES; ATTITUDES; RECOMMENDATIONS; PREFERENCES; MANAGEMENT; INTERVALS AB Background: In 2009, the American Congress of Obstetrics and Gynecology (ACOG) guidelines for cervical cancer screening changed significantly, to recommend less frequent screening than prior guidelines. The extent to which physicians in different specialties implemented these guidelines in the years following publication is unknown. Methods: Cross-sectional survey completed by 316 physicians in internal medicine, family medicine, and gynecology. Survey items assessed respondents' cervical cancer screening practices in women of different ages and medical histories. We used descriptive statistics to generate response distribution for survey items, and logistic regression models to compare responses among specialties. Results: Our response rate was 55% (316/575). Thirty-four percent of respondents' screening practices were inconsistent with ACOG guidelines for women under age 21, and 49% were inconsistent with guidelines for women over age 30. Internists (50%) were less likely than family medicine (89%, p<0.001) and gynecology (80%, p=0.02) physicians to delay pap testing until age 21. Internists (41%) were less likely than both family medicine (60%, p=0.009) and gynecology (68%, p=0.03) physicians to follow guidelines for women over age 30 (p=0.003). Overall 22% percent of physicians followed guidelines for women ages 21-29 years, with no significant differences between specialties. Differences remained significant in multivariable models. Conclusions: Despite consensus among national organizations as to optimal regimens for cervical cancer screening, a significant proportion of providers, especially in internal medicine, do not adhere to ACOG's 2009 guidelines. The lack of comprehensive guideline implementation suggests that adherence to new 2012 guidelines, which advocate for less frequent screening, will likely be suboptimal and discrepant by specialty. C1 [Corbelli, Jennifer; Borrero, Sonya; Kraemer, Kevin; Rubio, Doris; McNeil, Melissa] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA 15213 USA. [Borrero, Sonya] VA Pittsburgh Healthcare Syst, Ctr Res Hlth Equity & Promot, Pittsburgh, PA USA. [Borrero, Sonya; Kraemer, Kevin; Rubio, Doris; Karpov, Irina] Univ Pittsburgh, Ctr Res Hlth Care, Pittsburgh, PA 15213 USA. [Bonnema, Rachel] Univ Nebraska Med Ctr, Div Gen Internal Med, Omaha, NE USA. [McNamara, Megan] Case Western Reserve Univ, Sch Med, Div Gen Internal Med, Cleveland, OH USA. [McNamara, Megan] Louis Stokes Cleveland VA Med Ctr, Cleveland, OH USA. RP Corbelli, J (reprint author), Univ Pittsburgh, Dept Gen Internal Med, Med Ctr, 200 Lothrop St,MUH 9W-33, Pittsburgh, PA 15213 USA. EM corbellija@upmc.edu FU Thomas H. Nimick Jr. Competitive Research Fund; Department of Medicine at University of Pittsburgh; U.S. Department of Veteran's Affairs FX The Thomas H. Nimick Jr. Competitive Research Fund provided money for the purchase of iPads that were given as incentives to two randomly selected study participants. The Department of Medicine at University of Pittsburgh provided funding for data management. Dr. Corbelli's fellowship training is funded by the U.S. Department of Veteran's Affairs. These funding sources had no role in the study design or implementation, analysis of results, or manuscript preparation. NR 33 TC 11 Z9 11 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD MAY 1 PY 2014 VL 23 IS 5 BP 397 EP 403 DI 10.1089/jwh.2013.4475 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AG9KY UT WOS:000335739300006 PM 24380500 ER PT J AU Danielson, CK Walsh, K McCauley, J Ruggiero, KJ Brown, JL Sales, JM Rose, E Wingood, GM DiClemente, RJ AF Danielson, Carla Kmett Walsh, Kate McCauley, Jenna Ruggiero, Kenneth J. Brown, Jennifer L. Sales, Jessica M. Rose, Eve Wingood, Gina M. DiClemente, Ralph J. TI HIV-Related Sexual Risk Behavior Among African American Adolescent Girls SO JOURNAL OF WOMENS HEALTH LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; SUBSTANCE USE; PREVENTION INTERVENTIONS; ABUSE; STRESS; IMPACT; WOMEN; DISPARITIES; PREDICTORS; PARTNERS AB Background: Latent class analysis (LCA) is a useful statistical tool that can be used to enhance understanding of how various patterns of combined sexual behavior risk factors may confer differential levels of HIV infection risk and to identify subtypes among African American adolescent girls. Methods: Data for this analysis is derived from baseline assessments completed prior to randomization in an HIV prevention trial. Participants were African American girls (n=701) aged 14-20 years presenting to sexual health clinics. Girls completed an audio computer-assisted self-interview, which assessed a range of variables regarding sexual history and current and past sexual behavior. Results: Two latent classes were identified with the probability statistics for the two groups in this model being 0.89 and 0.88, respectively. In the final multivariate model, class 1 (the higher risk group; n=331) was distinguished by a higher likelihood of >5 lifetime sexual partners, having sex while high on alcohol/drugs, less frequent condom use, and history of sexually transmitted diseases (STDs), when compared with class 2 (the lower risk group; n=370). The derived model correctly classified 85.3% of participants into the two groups and accounted for 71% of the variance in the latent HIV-related sexual behavior risk variable. The higher risk class also had worse scores on all hypothesized correlates (e.g., self-esteem, history of sexual assault or physical abuse) relative to the lower risk class. Conclusions: Sexual health clinics represent a unique point of access for HIV-related sexual risk behavior intervention delivery by capitalizing on contact with adolescent girls when they present for services. Four empirically supported risk factors differentiated higher versus lower HIV risk. Replication of these findings is warranted and may offer an empirical basis for parsimonious screening recommendations for girls presenting for sexual healthcare services. C1 [Danielson, Carla Kmett; McCauley, Jenna; Ruggiero, Kenneth J.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA. [Walsh, Kate] Columbia Univ, Dept Epidemiol, New York, NY USA. [Ruggiero, Kenneth J.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. [Brown, Jennifer L.; Sales, Jessica M.; Rose, Eve; Wingood, Gina M.; DiClemente, Ralph J.] Texas Tech Univ, Dept Psychol, Lubbock, TX 79409 USA. [Sales, Jessica M.; Wingood, Gina M.; DiClemente, Ralph J.] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA. [Sales, Jessica M.; Wingood, Gina M.; DiClemente, Ralph J.] Emory Univ, Rollins Sch Publ Hlth, Ctr AIDS Res, Atlanta, GA 30322 USA. [Sales, Jessica M.; Wingood, Gina M.; DiClemente, Ralph J.] Emory Univ, Sch Med, Dept Pediat, Div Infect Dis Epidemiol & Immunol, Atlanta, GA USA. RP Danielson, CK (reprint author), Med Univ S Carolina, Dept Psychiat & Behav Sci, Natl Crime Victims Res & Treatment Ctr, MSC 861,Suite 207, Charleston, SC 29425 USA. EM danielso@musc.edu FU National Institute of Mental Health (NIMH) [5R01MH070537]; National Institute on Drug Abuse (NIDA) [K23DA018686, R01DA031285]; National Institute on Alcohol Abuse and Alcoholism (NIAAA) [P50 AA010761] FX The study was supported by grant award 5R01MH070537 from the National Institute of Mental Health (NIMH; PI: DiClemente). The preparation of this manuscript was supported by grant awards K23DA018686 and R01DA031285 from the National Institute on Drug Abuse (NIDA; PI: Danielson) and grant award P50 AA010761 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA; Center PI: Becker). The views, policies, and opinions expressed in this article are those of the authors and do not necessarily reflect those of NIMH, NIDA, and NIAAA. NR 40 TC 4 Z9 4 U1 3 U2 14 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD MAY 1 PY 2014 VL 23 IS 5 BP 413 EP 419 DI 10.1089/jwh.2013.4599 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AG9KY UT WOS:000335739300008 PM 24749895 ER PT J AU Golob, AL Wipf, JE AF Golob, Anna L. Wipf, Joyce E. TI Low Back Pain SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Acute low back pain; Chronic low back pain; Risk factors; Cause; Diagnosis; Imaging; Treatment; Sciatica ID CLINICAL-PRACTICE GUIDELINE; RANDOMIZED CONTROLLED-TRIAL; PRIMARY-CARE; LUMBAR SPINE; AMERICAN-COLLEGE; INCEPTION COHORT; PREVALENCE; SOCIETY; EPIDEMIOLOGY; DISABILITY AB Low back pain is one of the most frequent complaints for which patients are seen in primary care. Low back pain has a substantial economic impact, estimated at $100 billion per year including direct and indirect costs. The evaluation of low back pain involves a thorough history and physical examination. Imaging is only indicated when a more serious underlying cause or neurologic abnormality is suspected. Abnormalities detected on imaging do not strongly correlate with symptoms. Generally, a specific underlying cause for low back pain is not identified. Treatment consists of a multidisciplinary approach with goal to maintain function and minimize disability. C1 [Golob, Anna L.; Wipf, Joyce E.] Univ Washington, Dept Med, Seattle, WA 98195 USA. [Golob, Anna L.; Wipf, Joyce E.] VA Puget Sound Healthcare Syst, Gen Med Serv, Seattle, WA 98108 USA. RP Golob, AL (reprint author), VA Puget Sound Healthcare Syst, Gen Med Serv, S-123 PCC,1660 South Columbian Way, Seattle, WA 98108 USA. EM zilanna@uw.edu FU UpToDate chapter royalties FX Financial Disclosures: None (A.L. Golob); UpToDate chapter royalties (J.E. Wipf). NR 48 TC 6 Z9 10 U1 1 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 EI 1557-9859 J9 MED CLIN N AM JI Med. Clin. N. Am. PD MAY PY 2014 VL 98 IS 3 BP 405 EP + DI 10.1016/j.mcna.2014.01.003 PG 25 WC Medicine, General & Internal SC General & Internal Medicine GA AH5RK UT WOS:000336188500003 PM 24758954 ER PT J AU Berger, D AF Berger, Douglas TI Leg Discomfort: Beyond the Joints SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Leg pain; Paresthesia; Claudication; Neuropathy; Myalgia; Cramp ID LUMBAR SPINAL STENOSIS; PERIPHERAL ARTERIAL-DISEASE; CLINICAL-PRACTICE GUIDELINES; DEEP-VEIN THROMBOSIS; MERALGIA-PARESTHETICA; LOWER-EXTREMITY; MUSCLE CRAMPS; MUSCULOSKELETAL PAIN; DIAGNOSTIC-CRITERIA; AMERICAN-COLLEGE AB Although discussions of leg pain usually begin with the hip, knee, and ankle, patients often present with leg symptoms unrelated to articular or periarticular structures. Pain, paresthesias, cramping, heaviness, or numbness may arise from a variety of vascular, neurologic, and musculoskeletal causes beyond the joints. This article describes the presentation, diagnosis, and treatment of common causes of such symptoms, including peripheral arterial disease, chronic venous insufficiency, deep vein thrombosis, lumbosacral radiculopathy, lumbar spinal stenosis, peripheral neuropathy, statin myalgia, cramps, and restless legs syndrome. C1 Univ Washington, VA Puget Sound, Dept Med, Gen Med Serv, Seattle, WA 98108 USA. RP Berger, D (reprint author), Univ Washington, VA Puget Sound, Dept Med, Gen Med Serv, 1660 S Columbian Way, Seattle, WA 98108 USA. EM douglas.berger@va.gov NR 91 TC 2 Z9 2 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 EI 1557-9859 J9 MED CLIN N AM JI Med. Clin. N. Am. PD MAY PY 2014 VL 98 IS 3 BP 429 EP + DI 10.1016/j.mcna.2014.01.004 PG 17 WC Medicine, General & Internal SC General & Internal Medicine GA AH5RK UT WOS:000336188500004 PM 24758955 ER PT J AU Overland, MK AF Overland, Maryann Katherine TI Dyspepsia SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Functional dyspepsia; Helicobacter pylori test and treat; Peptic ulcer disease; Gastroesophageal reflux disease ID PLACEBO-CONTROLLED TRIAL; GASTROESOPHAGEAL-REFLUX DISEASE; FUNCTIONAL GASTRODUODENAL DISORDERS; HELICOBACTER-PYLORI ERADICATION; RANDOMIZED CLINICAL-TRIAL; PROTON PUMP INHIBITOR; DOUBLE-BLIND; GASTRIC ACCOMMODATION; NONULCER DYSPEPSIA; SYMPTOMS AB Dyspepsia is a common and complex condition consisting of chronic upper gastrointestinal symptoms. A rational approach to diagnosis and treatment of dyspepsia includes identifying those patients with alarm symptoms and referring them for prompt endoscopy. Those without alarm symptoms can be differentiated into patients who do and do not have symptoms consistent with gastroesophageal reflux disease. In the absence of predominant heartburn and regurgitation, patients should be tested and treated for Helicobacter pylori. Functional (nonulcer) dyspepsia is a multifactorial disorder with several possible pathophysiologic mechanisms, but no clear guidelines for therapy. There is some evidence of efficacy of proton pump inhibitors, antisecretory agents, antidepressants, and psychotherapy for functional dyspepsia. C1 Univ Washington, VA Puget Sound Hlth Care Syst, Primary Care Clin, Div Gen Internal Med, Seattle, WA 98108 USA. RP Overland, MK (reprint author), Univ Washington, VA Puget Sound Hlth Care Syst, Primary Care Clin, Div Gen Internal Med, 1660 S Columbian Way, Seattle, WA 98108 USA. EM Maryann.Overland@va.gov NR 68 TC 5 Z9 6 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 EI 1557-9859 J9 MED CLIN N AM JI Med. Clin. N. Am. PD MAY PY 2014 VL 98 IS 3 BP 549 EP + DI 10.1016/j.mcna.2014.01.007 PG 18 WC Medicine, General & Internal SC General & Internal Medicine GA AH5RK UT WOS:000336188500009 PM 24758960 ER PT J AU Molnar, A McGee, S AF Molnar, Alexandra McGee, Steven TI Diagnosing and Treating Dizziness SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Dizziness; Vertigo; Epley; Primary care ID PAROXYSMAL POSITIONAL VERTIGO; HEAD IMPULSE TEST; MENIERES-DISEASE; DIZZY PATIENT; PERSISTENT DIZZINESS; EMERGENCY-DEPARTMENT; ELDERLY-PATIENTS; PRIMARY-CARE; POPULATION; COMMUNITY AB Dizziness is a common presenting concern in primary care practice. The most useful diagnostic approach in distinguishing different types of dizziness is a thorough history and physical examination; additional tests are rarely necessary. Effective treatments exist for many causes of dizziness, and these treatments are often accomplished in the clinic or at home without the need for medication. C1 [Molnar, Alexandra] Univ Washington, Harborview Med Ctr, Dept Med, Seattle, WA 98104 USA. [McGee, Steven] Univ Washington, Dept Med, Vet Affairs Puget Sound Healthcare Syst, Seattle Div, Seattle, WA 98108 USA. RP Molnar, A (reprint author), Univ Washington, Harborview Med Ctr, Dept Med, Box 359895,325 9th Ave, Seattle, WA 98104 USA. EM amolnar@uw.edu OI Molnar, Alexandra/0000-0003-3258-6782 NR 35 TC 3 Z9 3 U1 3 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 EI 1557-9859 J9 MED CLIN N AM JI Med. Clin. N. Am. PD MAY PY 2014 VL 98 IS 3 BP 583 EP + DI 10.1016/j.mcna.2014.01.014 PG 15 WC Medicine, General & Internal SC General & Internal Medicine GA AH5RK UT WOS:000336188500011 PM 24758962 ER PT J AU Evans, G AF Evans, Ginger TI Identifying and Treating the Causes of Neck Pain SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Neck pain; Cervical spondylosis; Radiculopathy; Myelopathy; Chronic pain ID 2000-2010 TASK-FORCE; CERVICAL SPONDYLOTIC MYELOPATHY; GENERAL-POPULATION; DISK DISEASE; DIAGNOSTIC-ACCURACY; DISORDERS; RADICULOPATHY; SPINE; BONE; ROOT AB Chronic neck pain is a common and often disabling problem. It can describe pain in the neck region alone or include related disorders of radiculopathy or myelopathy. This review of the literature is aimed at the practicing primary care provider, who is diagnosing and managing non-traumatic neck pain in the clinic. It includes an anatomic review, definition of related disorders, differential diagnosis, and discussion of common diagnostic uncertainty for mechanical neck pain. Important history and physical examination techniques, the role of imaging, and the available literature on conservative and invasive treatment options are reviewed. C1 Univ Washington, Dept Med, VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. RP Evans, G (reprint author), Univ Washington, Dept Med, VA Puget Sound Hlth Care Syst, 1660 South Columbia Way,S-123-PCC, Seattle, WA 98108 USA. EM gingere@u.washington.edu NR 73 TC 2 Z9 2 U1 1 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 EI 1557-9859 J9 MED CLIN N AM JI Med. Clin. N. Am. PD MAY PY 2014 VL 98 IS 3 BP 645 EP + DI 10.1016/j.mcna.2014.01.015 PG 18 WC Medicine, General & Internal SC General & Internal Medicine GA AH5RK UT WOS:000336188500015 PM 24758966 ER PT J AU Tanner, CM Meng, CC Ravina, B Lang, A Kurlan, R Marek, K Oakes, D Seibyl, J Flagg, E Gauger, L Guest, DD Goetz, CG Kieburtz, K DiEuliis, D Fahn, S Elliott, RA Shoulson, I AF Tanner, Caroline M. Meng, Cheryl C. Ravina, Bernard Lang, Anthony Kurlan, Roger Marek, Kenneth Oakes, David Seibyl, John Flagg, Emily Gauger, Lisa Guest, Dolores D. Goetz, Christopher G. Kieburtz, Karl DiEuliis, Diane Fahn, Stanley Elliott, Robin A. Shoulson, Ira TI A Practical Approach to Remote Longitudinal Follow-up of Parkinson's Disease: The FOUND Study SO MOVEMENT DISORDERS LA English DT Article DE Parkinson's disease; longitudinal; follow-up ID RATING-SCALE; SYDNEY MULTICENTER; CLINICAL-TRIAL; PROGRESSION; RETENTION; DEMENTIA; RECRUITMENT; ASSESSMENTS; IMPAIRMENT; DISABILITY AB The objective of this study was to examine a remote method for maintaining long-term contact with Parkinson's disease (PD) patients participating in clinical studies. Long-term follow-up of PD patients is needed to fill critical information gaps on progression, biomarkers, and treatment. Prospective in-person assessment can be costly and may be impossible for some patients. Remote assessment using mail and telephone contact may be a practical follow-up method. Patients enrolled in the multi-center Longitudinal and Biomarker Study in Parkinson's Disease (LABS-PD) in-person follow-up study in 2006 were invited to enroll in Follow-up of Persons With Neurologic Diseases (FOUND), which is overseen by a single center under a separate, central institutional review board protocol. FOUND uses mailed questionnaires and telephone interviews to assess PD status. FOUND follow-up continued when LABS-PD in-person visits ended in 2011. Retention and agreement between remote and in-person assessments were determined. In total, 422 of 499 (84.5%) of eligible patients volunteered, AND 96% of participants were retained. Of 60 patients who withdrew consent from LABS-PD, 51 were retained in FOUND. Of 341 patients who were active in LABS-PD, 340 were retained in FOUND (99.7%) when the in-person visits ceased. Exact agreement between remote and in-person assessments was 80% for diagnosis, disease features (eg, dyskinesias), and PD medication. Correlation between expert-rated and self-reported Unified Parkinson's Disease Rating Scale and Movement Disorder Society Unified Parkinson's Disease Rating Scale, which were examined at times separated by several months, was moderate or substantial for most items. Retention was excellent using remote follow-up of research participants with PD, providing a safety net when combined with in-person visits, and also is effective as a stand-alone assessment method, providing a useful alternative when in-person evaluation is not feasible. (c) 2014 International Parkinson and Movement Disorder Society C1 [Tanner, Caroline M.; Meng, Cheryl C.; Guest, Dolores D.; Fahn, Stanley] Parkinsons Inst, Sunnyvale, CA USA. [Tanner, Caroline M.] Stanford Univ, Dept Hlth Res & Policy, Palo Alto, CA 94304 USA. [Ravina, Bernard] Biogen Idec Inc, Cambridge, MA USA. [Lang, Anthony] Univ Toronto, Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Toronto, ON M5S 1A1, Canada. [Kurlan, Roger] Overlook Hosp, Atlantic Neurosci Inst, Summit, NJ USA. [Marek, Kenneth; Seibyl, John] Inst Neurodegenerat Disorders, New Haven, CT USA. [Oakes, David; Flagg, Emily; Kieburtz, Karl] Univ Rochester, Dept Neurol, Rochester, NY USA. [Gauger, Lisa] Duke Univ, Dept Neurol, Med Ctr, Durham, NC USA. [Goetz, Christopher G.] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA. [DiEuliis, Diane] US Dept HHS, Off Assistant Secretary Preparedness & Response, Washington, DC 20201 USA. Columbia Univ, Dept Neurol, New York, NY USA. [Elliott, Robin A.] Parkinsons Dis Fdn, New York, NY USA. [Shoulson, Ira] Georgetown Univ, Med Ctr, Dept Neurol, Washington, DC 20007 USA. RP Tanner, CM (reprint author), San Francisco VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, 4150 Clement St 127P, San Francisco, CA 94121 USA. EM ctannermd@aol.com FU Parkinson's Disease Foundation; National Institutes of Health; H. Lundbeck A/S; James Sharron Clark; Cephalon, Inc. FX This study was supported by the Parkinson's Disease Foundation; the National Institutes of Health; Cephalon, Inc.; H. Lundbeck A/S; and James & Sharron Clark. NR 40 TC 5 Z9 5 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-3185 EI 1531-8257 J9 MOVEMENT DISORD JI Mov. Disord. PD MAY PY 2014 VL 29 IS 6 BP 743 EP 749 DI 10.1002/mds.25814 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA AG4BI UT WOS:000335363300008 PM 24515275 ER PT J AU Cholerton, BA Zabetian, CP Wan, JY Montine, TJ Quinn, JF Mata, IF Chung, KA Peterson, A Espay, AJ Revilla, FJ Devoto, J Watson, GS Hu, SC Leverenz, JB Edwards, KL AF Cholerton, Brenna A. Zabetian, Cyrus P. Wan, Jia Y. Montine, Thomas J. Quinn, Joseph F. Mata, Ignacio F. Chung, Kathryn A. Peterson, Amie Espay, Alberto J. Revilla, Fredy J. Devoto, Johnna Watson, G. Stennis Hu, Shu-Ching Leverenz, James B. Edwards, Karen L. TI Evaluation of Mild Cognitive Impairment Subtypes in Parkinson's Disease SO MOVEMENT DISORDERS LA English DT Article DE Parkinson disease; cognition; mild cognitive impairment; neuropsychological assessment ID MINI-MENTAL-STATE; DIAGNOSTIC-CRITERIA; NORMATIVE DATA; DEMENTIA; TASK; ALZHEIMERS; CIRCUITRY; INCIDENT; DECLINE; COHORT AB Mild cognitive impairment in Parkinson's disease (PD-MCI) is common and increases the risk for dementia. Establishing distinct PD-MCI cognitive subtypes could be valuable for eventually predicting those most likely to convert to dementia. However, the study of PD-MCI subtypes has not yielded consistent results among cohorts. To determine whether there are distinct cognitive subtypes among participants diagnosed with PD-MCI in the Pacific Northwest Udall Center Clinical Consortium, we cognitively subtyped 95 patients with PD-MCI, using the Movement Disorders Society Task Force diagnostic guidelines. Psychometric test scores were then subjected to principle components factor analysis to determine whether similar cognitive subgroups could be identified using statistical methodology. Multiple-domain PD-MCI was diagnosed in 95% of the sample, and a range of cognitive impairments were noted. Factor analysis yielded seven factors and demonstrated overlap of phonemic verbal fluency on two factors, as well as the loading of verbal fluency on the same factor as a visuospatial measure; however, these factors did not partition the sample into distinct cognitive subtypes. Separation of cognitive subtypes based on the current PD-MCI criteria, or via statistical methods, may not provide sufficient information to describe distinct PD groups. Future efforts to validate the PD-MCI criteria and identify combinations of genetic or other risk factors for cognitive impairment are warranted. (c) 2014 International Parkinson and Movement Disorder Society C1 [Cholerton, Brenna A.; Zabetian, Cyrus P.; Mata, Ignacio F.; Leverenz, James B.] Geriatr Res Educ & Clin Ctr, Seattle, WA USA. [Zabetian, Cyrus P.; Leverenz, James B.] Parkinsons Dis Res Educ & Clin Ctr, Seattle, WA USA. [Leverenz, James B.] Vet Affairs Puget Sound Hlth Care Syst, Mental Illness Res Educ & Clin Ctr, Seattle, WA USA. [Cholerton, Brenna A.; Watson, G. Stennis; Leverenz, James B.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Zabetian, Cyrus P.; Hu, Shu-Ching; Leverenz, James B.] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA. [Wan, Jia Y.; Edwards, Karen L.] Univ Washington, Dept Epidemiol, Sch Med, Seattle, WA 98195 USA. [Montine, Thomas J.] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA. [Quinn, Joseph F.; Chung, Kathryn A.; Peterson, Amie] Portland VA Med Ctr, Portland, OR USA. [Quinn, Joseph F.; Chung, Kathryn A.; Peterson, Amie] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA. [Espay, Alberto J.; Revilla, Fredy J.; Devoto, Johnna] Univ Cincinnati, Dept Neurol & Rehabil Med, Cincinnati, OH USA. [Revilla, Fredy J.] Cincinnati Veteran Affairs Med Ctr, Cincinnati, OH USA. RP Cholerton, BA (reprint author), VA Puget Sound Hlth Care Syst, GRECC A-182,9600 Vet Dr SW, Tacoma, WA 98493 USA. EM bchol@u.washington.edu OI Espay, Alberto/0000-0002-3389-136X; Zabetian, Cyrus/0000-0002-7739-4306 FU Nancy and Buster Alvord Endowment; Department of Veterans Affairs; [NS065070]; [NS062684] FX This study was supported by NS062684 and NS065070, the Nancy and Buster Alvord Endowment, and the Department of Veterans Affairs. The funding sources did not provide scientific input for the study. NR 48 TC 16 Z9 16 U1 1 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-3185 EI 1531-8257 J9 MOVEMENT DISORD JI Mov. Disord. PD MAY PY 2014 VL 29 IS 6 BP 756 EP 764 DI 10.1002/mds.25875 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA AG4BI UT WOS:000335363300010 PM 24710804 ER PT J AU Meffert, SM Abdo, AO Abd Alla, OA Elmakki, YOM Omer, AA Yousif, S Metzler, TJ Marmar, CR AF Meffert, Susan M. Abdo, Akram Osman Abd Alla, Omayma Ahmed Elmakki, Yasir Omer Mustafa Omer, Afrah Abdelrahim Yousif, Sahar Metzler, Thomas J. Marmar, Charles R. TI A Pilot Randomized Controlled Trial of Interpersonal Psychotherapy for Sudanese Refugees in Cairo, Egypt SO PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY LA English DT Article DE refugee; Sudan; global mental health; PTSD; depression; violence ID POSTTRAUMATIC-STRESS-DISORDER; WORLD-TRADE-CENTER; SOCIAL SUPPORT; VIETNAM VETERANS; TRAUMATIC STRESS; MENTAL-HEALTH; RURAL UGANDA; RISK-FACTORS; ATTACHMENT; DEPRESSION AB Approximately one third of a population exposed to mass violence develops posttraumatic stress disorder (PTSD) and approximately half develops depression, yet little is known about how to effectively treat these populations. This study's objective was to examine the impact of interpersonal psychotherapy (IPT) on Sudanese refugees living in Cairo, Egypt, who had symptoms of PTSD. A randomized controlled trial (April-August 2008) with 22 Sudanese refugees in Cairo, Egypt, tested two hypotheses: (1) After IPT, participants will have fewer symptoms of depression and PTSD compared with waitlist controls. (2) After IPT, participants will have less interpersonal violence compared with waitlist controls. Participants were randomly assigned to either 6 sessions of IPT delivered by Sudanese community therapists without previous mental health training or a waitlist control group. Measures taken at baseline and trial conclusion included the Harvard Trauma Questionnaire, the Beck Depression Index-II, the Conflict Tactics Scale, and the State-Trait Anger Inventory, all translated and adapted for local use. The effect sizes of IPT treatment for PTSD symptoms, depression, state anger, trait anger, and Conflict Tactics Scale-Violence Toward Household were -2.52, -2.38, -1.21, -1.43, and -0.84, respectively. IPT predicted a significant decrease in symptoms of PTSD, state anger, and depression using a conservative intent-to-treat analysis. This study represents the first randomized controlled trial of IPT to address PTSD, depression, and interpersonal violence in a refugee population. The study's preliminary success has positive implications for development of effective and sustainable mental health interventions to support the recovery of traumatized populations. C1 [Meffert, Susan M.; Marmar, Charles R.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. [Abdo, Akram Osman; Abd Alla, Omayma Ahmed; Elmakki, Yasir Omer Mustafa; Omer, Afrah Abdelrahim; Yousif, Sahar] Maan Org, Cairo, Egypt. [Abd Alla, Omayma Ahmed] St Andrews United Church Cairo, Cairo, Egypt. [Metzler, Thomas J.] San Francisco Vet Adm Med Ctr, Mental Hlth Serv, San Francisco, CA USA. RP Meffert, SM (reprint author), 50 Beale St,Suite 1200,Box 1224, San Francisco, CA 94105 USA. EM SusanM@lppi.uscf.edu NR 55 TC 5 Z9 5 U1 5 U2 21 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 1942-9681 EI 1942-969X J9 PSYCHOL TRAUMA-US JI Psychol. Trauma PD MAY PY 2014 VL 6 IS 3 BP 240 EP 249 DI 10.1037/a0023540 PG 10 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AH4FC UT WOS:000336081500007 ER PT J AU Davis, MM Freeman, M Kaye, J Vuckovic, N Buckley, DI AF Davis, Melinda M. Freeman, Michele Kaye, Jeffrey Vuckovic, Nancy Buckley, David I. TI A Systematic Review of Clinician and Staff Views on the Acceptability of Incorporating Remote Monitoring Technology into Primary Care SO TELEMEDICINE AND E-HEALTH LA English DT Article DE home health monitoring; e-health; telehealth ID NORTHERN GERMANY; CHRONIC DISEASE; TELEHOMECARE; PILOT; PROGRAM; DEVICES; DESIGN; ISSUES; HEALTH; HOME AB Objective:Remote monitoring technology (RMT) may enhance healthcare quality and reduce costs. RMT adoption depends on perceptions of the end-user (e.g., patients, caregivers, healthcare providers). We conducted a systematic review exploring the acceptability and feasibility of RMT use in routine adult patient care, from the perspectives of primary care clinicians, administrators, and clinic staff.Materials and Methods:We searched the databases of Medline, IEEE Xplore, and Compendex for original articles published from January 1996 through February 2013. We manually screened bibliographies of pertinent studies and consulted experts to identify English-language studies meeting our inclusion criteria.Results:Of 939 citations identified, 15 studies reported in 16 publications met inclusion criteria. Studies were heterogeneous by country, type of RMT used, patient and provider characteristics, and method of implementation and evaluation. Clinicians, staff, and administrators generally held positive views about RMTs. Concerns emerged regarding clinical relevance of RMT data, changing clinical roles and patterns of care (e.g., reduced quality of care from fewer patient visits, overtreatment), insufficient staffing or time to monitor and discuss RMT data, data incompatibility with a clinic's electronic health record (EHR), and unclear legal liability regarding response protocols.Conclusions:This small body of heterogeneous literature suggests that for RMTs to be adopted in primary care, researchers and developers must ensure clinical relevance, support adequate infrastructure, streamline data transmission into EHR systems, attend to changing care patterns and professional roles, and clarify response protocols. There is a critical need to engage end-users in the development and implementation of RMT. C1 [Davis, Melinda M.; Buckley, David I.] Oregon Hlth & Sci Univ, Oregon Rural Practice Based Res Network, Portland, OR 97239 USA. [Davis, Melinda M.; Buckley, David I.] Oregon Hlth & Sci Univ, Dept Family Med, Portland, OR 97239 USA. [Kaye, Jeffrey] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97239 USA. [Buckley, David I.] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA. [Buckley, David I.] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97239 USA. [Kaye, Jeffrey] Oregon Hlth & Sci Univ, Oregon Ctr Aging & Technol, Portland, OR 97239 USA. [Freeman, Michele] Portland VA Med Ctr, VA Evidence Based Synth Program, Portland, OR USA. [Kaye, Jeffrey] Portland VA Med Ctr, Dept Neurol, Portland, OR USA. [Vuckovic, Nancy] Intel Corp, Hillsboro, OR 97124 USA. RP Davis, MM (reprint author), Oregon Hlth & Sci Univ, Dept Family Med, 3181 SW Sam Jackson Pk Rd,Mail Code L222, Portland, OR 97239 USA. EM davismel@ohsu.edu; freemanm@ohsu.edu OI Kaye, Jeffrey/0000-0002-9971-3478 FU Oregon Roybal Center for Translational Research on Aging at OHSU, Portland, OR [P30AG024978]; Clinical and Translational Science Award from the National Center for Research Resources, National Institutes of Health [1 UL1 RR024140 01]; National Institute on Aging, National Institutes of Health [P30AG024978, P30AG008017] FX We thank Andrew Hamilton, Oregon Health & Science University (OHSU) senior reference and instruction librarian, for his assistance with the search strategy. Funding for this project is provided by the Oregon Roybal Center for Translational Research on Aging (grant P30AG024978) at OHSU, Portland, OR, and by a Clinical and Translational Science Award to OHSU (grant 1 UL1 RR024140 01 from the National Center for Research Resources, National Institutes of Health). J.K.'s time was supported by grants P30AG024978 and P30AG008017 from the National Institute on Aging, National Institutes of Health. NR 28 TC 6 Z9 6 U1 0 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 EI 1556-3669 J9 TELEMED E-HEALTH JI Telemed. e-Health PD MAY 1 PY 2014 VL 20 IS 5 BP 428 EP 438 DI 10.1089/tmj.2013.0166 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA AG4MG UT WOS:000335393400006 PM 24731239 ER PT J AU Fazeli, PL Doyle, KL Scott, JC Iudicello, JE Casaletto, KB Weber, E Moore, DJ Morgan, EE Grant, I Woods, SP AF Fazeli, Pariya L. Doyle, Katie L. Scott, J. Cobb Iudicello, Jennifer E. Casaletto, Kaitlin B. Weber, Erica Moore, David J. Morgan, Erin E. Grant, Igor Woods, Steven Paul CA HIV Neurobehav Res Program HNRP TI Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Aging; Disability; Everyday functioning; Learning and memory ID HUMAN-IMMUNODEFICIENCY-VIRUS; VERBAL MEMORY PERFORMANCE; NEUROCOGNITIVE DISORDERS; NEUROPSYCHOLOGICAL PERFORMANCE; COGNITIVE IMPAIRMENT; MEDICATION ADHERENCE; CORTICAL HYPOTHESIS; CONSTRUCT-VALIDITY; YOUNGER ADULTS; LEARNING TEST AB Aging and HIV are both risk factors for memory deficits and declines in real-world functioning. However, we know little about the profile of memory deficits driving instrumental activities of daily living (IADL) declines across the lifespan in HIV. This study examined 145 younger (< 50 years) and 119 older (a parts per thousand yen50 years) adults with HIV who completed the California Verbal Learning Test-Second Edition (CVLT-II), the Wechsler Memory Scale-Third Edition Logical Memory subtest (WMS-III LM), and a modified Lawton and Brody ADL questionnaire. No memory predictors of IADL dependence emerged in the younger cohort. In the older group, IADL dependence was uniquely associated with worse performance on all primary CVLT-II variables, as well as elevated recency effects. Poorer immediate and delayed recall of the WMS-III LM was also associated with IADL dependence, although recognition was intact. Findings suggest older HIV-infected adults with shallow encoding and forgetting are at risk for IADL dependence. C1 [Fazeli, Pariya L.; Doyle, Katie L.; Iudicello, Jennifer E.; Casaletto, Kaitlin B.; Weber, Erica; Moore, David J.; Morgan, Erin E.; Grant, Igor; Woods, Steven Paul] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. [Doyle, Katie L.; Casaletto, Kaitlin B.; Weber, Erica] San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92182 USA. [Doyle, Katie L.; Casaletto, Kaitlin B.; Weber, Erica] Univ Calif San Diego, San Diego, CA 92103 USA. [Scott, J. Cobb] Univ Penn, Dept Psychiat, Perelman Sch Med, Neuropsychiat Sect, Philadelphia, PA 19104 USA. [Scott, J. Cobb] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Scott, J. Cobb] VISN 4 Mental Illness Res Educ & Clin Ctr MIRECC, Philadelphia, PA USA. RP Woods, SP (reprint author), Univ Calif San Diego, Dept Psychiat 8231, 220 Dickinson St,Suite B, San Diego, CA 92103 USA. EM spwoods@ucsd.edu FU National Institutes of Health (NIH) [R01-MH073419, T32-DA031098, P30-MH062512, F31-DA034510, F31-DA035708, L30-DA032120, L30-DA034362]; California HIV/AIDS Research Program (CHRP) [R25-MH081482, R01-MH099987, L30-AG045921, ID10-SD-057] FX This research was supported by National Institutes of Health (NIH) grants R01-MH073419, T32-DA031098, P30-MH062512, F31-DA034510, F31-DA035708, L30-DA032120, and L30-DA034362. Dr. Fazeli is supported by R25-MH081482, R01-MH099987, L30-AG045921, and ID10-SD-057 from California HIV/AIDS Research Program (CHRP). NR 64 TC 2 Z9 2 U1 0 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 EI 1873-5843 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD MAY PY 2014 VL 29 IS 3 BP 278 EP 288 DI 10.1093/arclin/acu009 PG 11 WC Psychology, Clinical; Psychology SC Psychology GA AG9WC UT WOS:000335769700007 PM 24695591 ER PT J AU Pietrzak, RH Scott, JC Neumeister, A Lim, YY Ames, D Ellis, KA Harrington, K Lautenschlager, NT Szoeke, C Martins, RN Masters, CL Villemagne, VL Rowe, CC Maruff, P AF Pietrzak, Robert H. Scott, J. Cobb Neumeister, Alexander Lim, Yen Ying Ames, David Ellis, Kathryn A. Harrington, Karra Lautenschlager, Nicola T. Szoeke, Cassandra Martins, Ralph N. Masters, Colin L. Villemagne, Victor L. Rowe, Christopher C. Maruff, Paul CA Australian Imaging Biomarkers TI Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study SO BRITISH JOURNAL OF PSYCHIATRY LA English DT Article ID COGNITIVE IMPAIRMENT; DEPRESSION AB Although beta-amyloid, anxiety and depression have been linked cross-sectionally to reduced memory function in healthy older adults without dementia, prospective data evaluating these associations are lacking. Using data from an observational cohort study of 178 healthy older adults without dementia followed for 3 years, we found that anxiety symptoms significantly moderated the relationship between beta-amyloid level and decline in verbal (Cohen's d=0.65) and episodic (Cohen's d=0.38) memory. Anxiety symptoms were additionally linked to greater decline in executive function, irrespective of beta-amyloid and other risk factors. These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid. C1 [Pietrzak, Robert H.; Scott, J. Cobb] VA Connecticut Healthcare Syst, Clin Neurosci Div, US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, West Haven, CT USA. [Pietrzak, Robert H.; Scott, J. Cobb] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Neumeister, Alexander] NYU, Sch Med, Dept Psychiat, New York, NY USA. [Neumeister, Alexander] NYU, Dept Radiol, Sch Med, New York, NY 10016 USA. [Lim, Yen Ying; Ellis, Kathryn A.; Harrington, Karra; Masters, Colin L.; Villemagne, Victor L.; Maruff, Paul] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia. [Ames, David; Ellis, Kathryn A.] Univ Melbourne, Kew & Natl Ageing Res Inst, Dept Psychiat, Acad Unit Psychiat Old Age,St Vincents Hlth, Parkville, Vic 3052, Australia. [Lautenschlager, Nicola T.] Univ Melbourne, Dept Psychiat, Acad Unit Psychiat Old Age, St Vincents Hlth, Kew, Vic, Australia. [Lautenschlager, Nicola T.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia. [Lautenschlager, Nicola T.] Univ Western Australia, WA Ctr Hlth & Ageing, Perth, WA 6009, Australia. [Szoeke, Cassandra] Natl Ageing Res Inst, Parkville, Vic, Australia. [Szoeke, Cassandra] Univ Melbourne, Mental Hlth Res Inst, Parkville, Vic 3052, Australia. [Szoeke, Cassandra] CSIRO Preventat Hlth Flagship, Parkville, Vic, Australia. [Martins, Ralph N.] Edith Cowan Univ, Sch Exercise Biomed & Hlth Sci, Ctr Excellence Alzheimers Dis Res & Care, Perth, WA, Australia. [Villemagne, Victor L.; Rowe, Christopher C.] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia. [Villemagne, Victor L.; Rowe, Christopher C.] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia. [Villemagne, Victor L.; Rowe, Christopher C.] Univ Melbourne, Austin Hlth, Dept Med, Heidelberg, Vic, Australia. [Maruff, Paul] Cog State Ltd, Melbourne, Vic, Australia. RP Pietrzak, RH (reprint author), VA Connecticut Healthcare Syst, Natl Ctr PTSD, 950 Campbell Ave 161E, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu OI Maruff, Paul/0000-0002-6947-9537; Szoeke, Cassandra/0000-0002-3698-2590 NR 10 TC 9 Z9 9 U1 0 U2 3 PU ROYAL COLLEGE OF PSYCHIATRISTS PI LONDON PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG, ENGLAND SN 0007-1250 EI 1472-1465 J9 BRIT J PSYCHIAT JI Br. J. Psychiatry PD MAY PY 2014 VL 204 IS 5 BP 400 EP 401 DI 10.1192/bjp.bp.113.134239 PG 2 WC Psychiatry SC Psychiatry GA AH3HY UT WOS:000336015500015 PM 24526746 ER PT J AU Friedman, MJ AF Friedman, Matthew J. TI Suicide Risk Among Soldiers Early Findings From Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) SO JAMA PSYCHIATRY LA English DT Editorial Material ID US MILITARY PERSONNEL; MENTAL-HEALTH C1 [Friedman, Matthew J.] US Dept Vet Affairs, Natl Ctr PTSD, Washington, DC USA. [Friedman, Matthew J.] Geisel Sch Med Dartmouth, Dept Psychiat, Hanover, NH USA. [Friedman, Matthew J.] Geisel Sch Med Dartmouth, Dept Pharmacol & Toxicol, Hanover, NH USA. RP Friedman, MJ (reprint author), VA Med Ctr, US Natl Ctr PTSD, Geisel Sch Med Dartmouth, Dept Pharmacol & Psychiat, 215 N Main St, White River Jct, VT 05009 USA. EM matthew.j.friedman@dartmouth.edu NR 10 TC 8 Z9 8 U1 1 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD MAY PY 2014 VL 71 IS 5 BP 487 EP 489 DI 10.1001/jamapsychiatry.2014.24 PG 3 WC Psychiatry SC Psychiatry GA AH2JP UT WOS:000335947600003 PM 24590002 ER PT J AU Byers, AL Covinsky, KE Neylan, TC Yaffe, K AF Byers, Amy L. Covinsky, Kenneth E. Neylan, Thomas C. Yaffe, Kristine TI Chronicity of Posttraumatic Stress Disorder and Risk of Disability in Older Persons SO JAMA PSYCHIATRY LA English DT Article ID COMORBIDITY SURVEY REPLICATION; WORLD-HEALTH-ORGANIZATION; QUALITY-OF-LIFE; FUNCTIONAL IMPAIRMENT; PHYSICAL-DISABILITY; PRIMARY-CARE; GERIATRIC DEPRESSION; FUTURE-RESEARCH; SYMPTOMS; DECLINE AB IMPORTANCE Little is known about the association between posttraumatic stress disorder (PTSD) and disability into later life. Most studies of late-life psychiatric disorders and function have focused on depression and generalized anxiety disorder. OBJECTIVES To determine the association between PTSD and disability among older adults and investigate if association differs by chronicity of PTSD. DESIGN, SETTING, AND PARTICIPANTS In total, 3287 participants 55 years and older (mean [SD] age, 66.0 [8.7] years, 60.1% women) involved in the Collaborative Psychiatric Epidemiology Surveys (2001-2003), including 3 aggregated, nationally representative studies (National Comorbidity Survey Replication, National Survey of American Life, and National Latino and Asian American Study). Analyses used weights and complex design-corrected statistical tests to infer generalizability to the US population. MAIN OUTCOMES AND MEASURES Disability defined by 5 domains (out of role, self-care, mobility, cognition, and social) using theWorld Health Organization Disability Assessment Schedule. RESULTS Of the 3.7% older adults who had a history of PTSD defined by DSM-IV criteria, 1.8% had persistent PTSD into later life (age of onset < 55 years as well as a recent diagnosis). Frequency of any disability was 79.7% for persistent PTSD, 69.6% for pre-late life (age of onset < 55 years and age at last diagnosis < 55 years), and 36.9% for no PTSD (P <.001). In logistic regression analyses, adjusting for demographics, smoking, individual medical conditions, depression, generalized anxiety disorder, and substance use disorders, respondents with persistent PTSD were 3 times more likely to have any disability than were respondents with no PTSD (odds ratio, 3.18; 95% CI, 1.32-7.64). Global disability results were nonsignificant for pre-late life relative to no PTSD (odds ratio, 1.99; 95% CI, 0.97-4.08). CONCLUSIONS AND RELEVANCE Disability in older Americans is strongly associated with PTSD, particularly PTSD that persists into later life. These findings suggest that monitoring and treatment of PTSD are important over the long term. C1 [Byers, Amy L.; Neylan, Thomas C.; Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Byers, Amy L.; Covinsky, Kenneth E.; Neylan, Thomas C.; Yaffe, Kristine] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Covinsky, Kenneth E.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. RP Byers, AL (reprint author), San Francisco VA Med Ctr, Dept Psychiat, 4150 Clement St,Mail Code 116H, San Francisco, CA 94121 USA. EM amy.byers@ucsf.edu FU Department of Defense [W81XWH-11-2-0189]; National Institute of Mental Health [U01-MH60220, U01-MH57716, U01-MH062209, U01-MH62207]; National Institute of Drug Abuse [R01-DA12058-05]; Substance Abuse and Mental Health Services Administration; Robert Wood Johnson Foundation [044708]; National Institutes of Health; University of Michigan, Ann Arbor FX This study was supported by Department of Defense grant W81XWH-11-2-0189, which was administered by the Northern California Institute for Research and Education and with resources of the San Francisco Veterans Affairs Medical Center (Dr Byers), and in part by a K24 Midcareer Investigator Award (AG031155) from the National Institute on Aging (Dr Yaffe). The National Comorbidity Survey Replication was supported by the National Institute of Mental Health (U01-MH60220), with supplemental support from the National Institute of Drug Abuse (R01-DA12058-05), the Substance Abuse and Mental Health Services Administration, the Robert Wood Johnson Foundation (044708), and the JohnW. Alden Trust. The National Survey of American Life was supported by the National Institute of Mental Health (U01-MH57716), with supplemental support from the Office of Behavioral and Social Sciences Research at the National Institutes of Health and the University of Michigan, Ann Arbor. The National Latino and Asian American Study was supported by the National Institute of Mental Health (U01-MH062209 and U01-MH62207), with supplemental support from the Office of Behavioral and Social Sciences Research at the National Institutes of Health, the Substance Abuse and Mental Health Services Agency, and the Latino Research Program Project (P01-MH059876). NR 40 TC 11 Z9 11 U1 3 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD MAY PY 2014 VL 71 IS 5 BP 540 EP 546 DI 10.1001/jamapsychiatry.2014.5 PG 7 WC Psychiatry SC Psychiatry GA AH2JP UT WOS:000335947600011 PM 24647756 ER PT J AU Yeghiazarians, Y Honbo, N Imhof, I Woods, B Aguilera, V Ye, JQ Boyle, AJ Karliner, JS AF Yeghiazarians, Yerem Honbo, Norman Imhof, Isabella Woods, Brandon Aguilera, Vanessa Ye, Jianqin Boyle, Andrew J. Karliner, Joel S. TI IL-15: A Novel Prosurvival Signaling Pathway in Cardiomyocytes SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY LA English DT Article DE stem cell; IL-15; survival; cardiomyocyte ID SPHINGOSINE 1-PHOSPHATE; ISCHEMIC-HEART; STEM-CELLS; FUNCTIONAL IMPROVEMENT; INTERLEUKIN-15; APOPTOSIS; HYPOXIA; ASSOCIATION; FIBROBLASTS; MYOCARDIUM AB Cardiovascular disease is the leading cause of death in Western countries. A major limitation of current treatments is the inability to efficiently repair or replace dead myocardium. Recently, stem cell-based therapies have been explored as an avenue to circumvent current therapeutic limitations. Overall, these therapies seem to result in small improvements in the contractile function of the heart. The exact mechanism(s) of action that underlie these improvements remain unknown, and it is believed that paracrine effects play a significant role. Previously, we had reported that an extract derived from bone marrow cells, in the absence of any live cell, contained cardioprotective soluble factors. In this study, we identify IL-15 as a putative cardioprotectant within the bone marrow cells paracrine profile. Using an in vitro culture system, we assessed the ability of IL-15 to protect cardiomyocytes under hypoxic conditions. For the first time, we have identified IL-15 receptors on the surface of cardiomyocytes and delineated the signaling system by which hypoxic cardiomyocytes may be protected from cellular death and rescued from oxidative stress with IL-15 treatment. C1 [Yeghiazarians, Yerem; Woods, Brandon; Aguilera, Vanessa; Ye, Jianqin; Boyle, Andrew J.; Karliner, Joel S.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Yeghiazarians, Yerem; Boyle, Andrew J.] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA. [Yeghiazarians, Yerem; Karliner, Joel S.] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA. [Honbo, Norman; Imhof, Isabella; Karliner, Joel S.] Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, San Francisco, CA 94143 USA. RP Yeghiazarians, Y (reprint author), Univ Calif San Francisco, Dept Med, 505 Parnassus Ave,Box 0103, San Francisco, CA 94143 USA. EM yeghiaza@medicine.ucsf.edu FU UCSF Translational Cardiac Stem Cell Program; Leone-Perkins Foundation; Torian Foundation; Vadasz Foundation; Foundation for Cardiac Research; Chatterjee Center for Cardiac Research; [HL R01 090606] FX Supported by the UCSF Translational Cardiac Stem Cell Program, the Leone-Perkins Foundation, the Torian Foundation and the Vadasz Foundation (all to Y.Y.), and by HL R01 090606, the Foundation for Cardiac Research, and the Chatterjee Center for Cardiac Research (all to J.S.K.). NR 27 TC 3 Z9 4 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0160-2446 EI 1533-4023 J9 J CARDIOVASC PHARM JI J. Cardiovasc. Pharmacol. PD MAY PY 2014 VL 63 IS 5 BP 406 EP 411 DI 10.1097/FJC.0000000000000061 PG 6 WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy GA AH2KZ UT WOS:000335951500003 PM 24805144 ER PT J AU Payne, VL Singh, H Meyer, AND Levy, L Harrison, D Graber, ML AF Payne, Velma L. Singh, Hardeep Meyer, Ashley N. D. Levy, Lewis Harrison, David Graber, Mark L. TI Patient-Initiated Second Opinions: Systematic Review of Characteristics and Impact on Diagnosis, Treatment, and Satisfaction SO MAYO CLINIC PROCEEDINGS LA English DT Review ID CANCER-PATIENTS; ALTERNATIVE MEDICINE; ANATOMIC PATHOLOGY; SURGICAL PATHOLOGY; ERRORS; NEURORADIOLOGY; 2ND-OPINION; CARE; INTERVENTIONS; CONSULTATION AB The impact of second opinions on diagnosis in radiology and pathology is well documented; however, the value of patient-initiated second opinions for diagnosis and treatment in general medical practice is unknown. We conducted a systematic review of patient-initiated second opinions to assess their impact on clinical outcomes and patient satisfaction and to determine characteristics and motivating factors of patients who seek a second opinion. We searched PubMed, EMBASE, Cochrane, and Academic OneFile databases using Medical Subject Headings (MeSH) indexes and keyword searches. Search terms included referral and consultation, patient-initiated, patient preference, patient participation, second opinion, second review, and diagnosis. Multiple reviewers screened abstracts and articles to determine eligibility and extract data. We assessed risk of bias using the Cochrane Risk of Bias Tool and rated study quality using Cochrane's GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach. We screened 1342 abstracts and reviewed full text of 41 articles, identifying 7 articles that reported clinical agreement data and 10 that discussed patient characteristics, motivation, and satisfaction. We found that a second opinion typically confirms the original diagnosis or treatment regimen but that 90% of patients with poorly defined conditions remain undiagnosed. However, 10% to 62% of second opinions yield a major change in the diagnosis, treatment, or prognosis. A larger fraction of patients receive different advice on treatment than on diagnosis. Factors motivating a second opinion include diagnosis or treatment confirmation, dissatisfaction with a consultation, desire for more information, persistent symptoms, or treatment complications. Patients generally believed that second opinions were valuable. Second opinions can result in diagnostic and treatment differences. The literature on patient-initiated second opinions is limited, and the accuracy of the second opinion through follow-up is generally unknown. Standardized methods and outcome measures are needed to determine the value of second opinions, and the potential of second opinions to reduce diagnostic errors merits more rigorous evaluation. (C) 2014 Mayo Foundation for Medical Education and Research C1 [Payne, Velma L.; Singh, Hardeep; Meyer, Ashley N. D.] Baylor Coll Med, Houston Vet Affairs Hlth Serv, Res & Dev Ctr Innovat Qual Effectiveness & Safety, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA. [Payne, Velma L.; Singh, Hardeep; Meyer, Ashley N. D.] Baylor Coll Med, Dept Med, Sect Hlth Serv Res, Houston, TX 77030 USA. [Levy, Lewis; Harrison, David] Best Doctors Inc, Boston, MA USA. [Graber, Mark L.] RTI Int, Res Triangle Pk, NC USA. RP Graber, ML (reprint author), 1 Breezy Hollow, St James, NY 11780 USA. EM mgraber@rti.org OI Graber, Mark/0000-0002-3600-0446; Meyer, Ashley/0000-0001-7993-8584 FU Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development [CIN 13-413]; Center for Innovations in Quality, Effectiveness and Safety; VA Office of Academic Affiliations, Washington; Houston VA Center for Innovations in Quality, Effectiveness and Safety [CIN 13-413] FX This work was supported in part by grant CIN 13-413 from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and the Center for Innovations in Quality, Effectiveness and Safety. Dr Payne is supported by the VA Office of Academic Affiliations, Washington, DC. Drs Singh and Meyer are supported by the Houston VA Center for Innovations in Quality, Effectiveness and Safety (CIN 13-413). NR 56 TC 7 Z9 7 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0025-6196 EI 1942-5546 J9 MAYO CLIN PROC JI Mayo Clin. Proc. PD MAY PY 2014 VL 89 IS 5 BP 687 EP 696 DI 10.1016/j.mayocp.2014.02.015 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AG6WU UT WOS:000335560400016 PM 24797646 ER PT J AU Kostin, A Siegel, JM Alam, MN AF Kostin, Andrey Siegel, Jerome M. Alam, Md. Noor TI Lack of Hypocretin Attenuates Behavioral Changes Produced by Glutamatergic Activation of the Perifornical-Lateral Hypothalamic Area SO SLEEP LA English DT Article DE orexin; hypocretin; perifornical area; prepro-orexin knockout; sleep; dorsomedial hypothalamus; lateral hypothalamus; N-methyl-D-aspartate ID OREXIN KNOCKOUT MICE; OREXIN/HYPOCRETIN NEURONS; SLEEP REGULATION; MOUSE MODELS; MCH NEURONS; NARCOLEPSY; WAKEFULNESS; RATS; DISCHARGE; WAKING AB Study Objectives: The hypocretins (HCRTs) are two hypothalamic peptides predominantly localized to neurons in the perifornical, dorsomedial, and lateral hypothalamic area (PF-LHA). Evidence suggests that HCRT signaling is critical for the promotion and stabilization of active-arousal and its loss or malfunction leads to symptoms of narcolepsy. In the PF-LHA, HCRT neurons are intermingled with glutamate-expressing neurons and also co-express glutamate. Evidence suggests that HCRT-glutamate interactions within the PF-LHA may play a critical role in maintaining behavioral arousal. However, the relative contributions of the glutamate and HCRT in sleep-wake regulation are not known. Design: We determined whether a lack of HCRT signaling in the prepro-orexin-knockout (HCRT-KO) mouse attenuates/compromises the wake-promoting ability of glutamatergic activation of the PF-LHA region. We used reverse microdialysis to deliver N-methyl-D-aspartate (NMDA) into the HCRT zone of the PF-LHA in HCRT-KO and wild-type (WT) mice to evaluate the contributions of glutamatergic vs. HCRT signaling in sleep-wake regulation. Measurements and Results: As compared to respective controls, local perfusion of NMDA into the PF-LHA, dose-dependently increased active-waking with concomitant reductions in nonREM and REM sleep in spontaneously sleeping WT as well as HCRT-KO mice. However, compared to WT, the NMDA-induced behavioral changes in HCRT-KO mice were significantly attenuated, as evidenced by the higher dose of NMDA needed and lower magnitude of changes induced in sleep-wake parameters. Although not observed in WT mice, the number of cataplectic events increased significantly during NMDA-induced behavioral arousal in HCRT-KO mice. Conclusions: The findings of this study are consistent with a hypothesis that synergistic interactions between hypocretin and glutamatergic mechanisms within the perifornical, dorsomedial, and lateral hypothalamic area are critical for maintaining behavioral arousal, especially arousal involving elevated muscle tone. C1 [Kostin, Andrey; Siegel, Jerome M.; Alam, Md. Noor] Vet Affairs Greater Los Angeles Healthcare Syst, Res Serv 151A3, Sepulveda, CA 91343 USA. [Siegel, Jerome M.] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA. [Siegel, Jerome M.] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA. [Alam, Md. Noor] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA. RP Alam, MN (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Res Serv 151A3, 16111 Plummer St, Sepulveda, CA 91343 USA. EM noor@ucla.edu FU Medical Research Service, US Department of Veterans Affairs [MH064109] FX This was not an industry supported study. This work was supported by the Medical Research Service, US Department of Veterans Affairs and MH064109. The authors have indicated no financial conflicts of interest. NR 55 TC 7 Z9 7 U1 0 U2 2 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD MAY 1 PY 2014 VL 37 IS 5 BP 1011 EP 1020 DI 10.5665/sleep.3680 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AH3UZ UT WOS:000336052600023 PM 24790280 ER PT J AU Schapira, MM Mackenzie, ER Lam, R Casarett, D Seluzicki, CM Barg, FK Mao, JJ AF Schapira, Marilyn M. Mackenzie, Elizabeth R. Lam, Regina Casarett, David Seluzicki, Christina M. Barg, Frances K. Mao, Jun J. TI Breast cancer survivors willingness to participate in an acupuncture clinical trial: a qualitative study SO SUPPORTIVE CARE IN CANCER LA English DT Article DE Breast cancer survivors; Acupuncture; Clinical trials; Decision making ID ALTERNATIVE MEDICINE USE; AFRICAN-AMERICANS; HOT FLASHES; COMPLEMENTARY; ATTITUDES; RECRUITMENT; CARE; MINORITIES; BARRIERS; ONCOLOGY AB Purpose Acupuncture is a complementary and alternative medicine (CAM) modality that shows promise as a component of supportive breast cancer care. Lack of robust recruitment for clinical trial entry has limited the evidence base for acupuncture as a treatment modality among breast cancer survivors. The objective of this study is to identify key decision-making factors among breast cancer survivors considering entry into an acupuncture clinical trial for treatment of symptoms. Methods Semistructured interviews were conducted among African-American (n = 12) and Caucasian (n = 13) breast cancer survivors. Verbatim transcripts were made and analyzed by two or more independent coders using NVivo software. Major recurring themes were identified and a theoretical framework developed. Results Six themes emerged reflecting key attributes of the decision to enter a clinical trial: (1) symptom appraisal, (2) practical barriers (e. g., distance and travel), (3) beliefs about the interventions (e. g., fear of needles and dislike of medications), (4) comfort with elements of clinical trial design (e. g., randomization, the nature of the control intervention, and blinding), (5) trust, and (6) altruism. African-American and Caucasian women weighed similar attributes but differed in the information sources sought regarding clinical trial entry and in concerns regarding the use of a placebo in a clinical trial. Conclusions Our findings contribute to the development of a theoretical model of decision making for breast cancer survivors considering participation in a CAM clinical trial. Insights regarding the decision making process can inform interventions to support informed decision making and robust recruitment to CAM trials among cancer survivors. C1 [Schapira, Marilyn M.] Univ Penn, Philadelphia VA Ctr Hlth Equ Res & Promot, Philadelphia, PA 19104 USA. [Schapira, Marilyn M.] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA. [Schapira, Marilyn M.; Mao, Jun J.] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA. [Mackenzie, Elizabeth R.] Univ Penn, Div Appl Psychol Human Dev, Grad Sch Educ, Philadelphia, PA 19104 USA. [Lam, Regina; Seluzicki, Christina M.; Barg, Frances K.; Mao, Jun J.] Univ Penn, Dept Family Med & Community Hlth, Perelman Sch Med, Philadelphia, PA 19104 USA. [Casarett, David] Univ Penn, Dept Med, Div Geriatr, Perelman Sch Med, Philadelphia, PA 19104 USA. [Barg, Frances K.] Univ Penn, Dept Anthropol, Sch Arts & Sci, Philadelphia, PA 19104 USA. RP Schapira, MM (reprint author), Univ Penn, Abramson Canc Ctr, Perelman Sch Med, 1122 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM mschap@upenn.edu FU American Cancer Society [CCCDA-08-107]; National Institute of Health/National Center for Complementary and Alternative Medicine [R21 AT004695, K23004112] FX This research is funded in part from American Cancer Society CCCDA-08-107 award. Mao is a recipient of the National Institute of Health/National Center for Complementary and Alternative Medicine grants R21 AT004695 and K23004112. The funding agencies had no role in the design and conduct of the study. NR 35 TC 3 Z9 4 U1 1 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0941-4355 EI 1433-7339 J9 SUPPORT CARE CANCER JI Support. Care Cancer PD MAY PY 2014 VL 22 IS 5 BP 1207 EP 1215 DI 10.1007/s00520-013-2073-3 PG 9 WC Oncology; Health Care Sciences & Services; Rehabilitation SC Oncology; Health Care Sciences & Services; Rehabilitation GA AG9XY UT WOS:000335774600008 PM 24362843 ER PT J AU Thames, AD Arbid, N Sayegh, P AF Thames, April D. Arbid, Natalie Sayegh, Philip TI Cannabis use and neurocognitive functioning in a non-clinical sample of users SO ADDICTIVE BEHAVIORS LA English DT Article DE Cannabis; Cognition; Premorbid IQ; Abstinence; Past use; Abuse ID ADOLESCENT MARIJUANA USERS; ALCOHOL-USE; NEUROPSYCHOLOGICAL PERFORMANCE; EXECUTIVE FUNCTION; USE-DISORDERS; SUBSTANCE USE; YOUNG-ADULTS; DRUG-USE; BEHAVIOR; OUTCOMES AB Objective: With the recent debates over marijuana legalization and increases in use, it is critical to examine its role in cognition. While many studies generally support the adverse acute effects of cannabis on neurocognition, the non-acute effects remain less clear. The current study used a cross-sectional design to examine relationships between recent and past cannabis use on neurocognitive functioning in a non-clinical adult sample. Method: One hundred and fifty-eight participants were recruited through fliers distributed around local college campuses and the community. All participants completed the Brief Drug Use History Form, the Structured Clinical Interview for DSM-IV Disorders, and neurocognitive assessment, and underwent urine toxicology screening. Participants consisted of recent users (n = 68), past users (n = 41), and non-users (n = 49). Results: Recent users demonstrated significantly (p < .05) worse performance than non-users across cognitive domains of attention/working memory (M = 42.4, SD = 16.1 vs. M = 50.5, SD = 10.2), information processing speed (M = 44.3, SD = 7.3 vs. M = 52.1, SD = 11.0), and executive functioning (M = 43.6, SD = 13.4 vs. M = 48.6, SD = 7.2). There were no statistically significant differences between recent users and past users on neurocognitive performance. Frequency of cannabis use in the last 4 weeks was negatively associated with global neurocognitive performance and all individual cognitive domains. Similarly, amount of daily cannabis use was negatively associated with global neurocognitive performance and individual cognitive domains. Conclusions: Our results support the widespread adverse effects of cannabis use on neurocognitive functioning. Although some of these adverse effects appear to attenuate with abstinence, past users' neurocognitive functioning was consistently lower than non-users. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Thames, April D.; Sayegh, Philip] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Arbid, Natalie] Greater Los Angeles VA Healthcare Syst, Los Angeles, CA 90024 USA. RP Thames, AD (reprint author), Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, 740 Westwood Plaza C8-226, Los Angeles, CA 90095 USA. EM athames@mednet.ucla.edu RI Thames, April/K-1964-2014 OI Thames, April/0000-0001-8414-7189 FU National Academy of Neuropsychology; NIH/NIMH [K-23 MH095661] FX Funding for this study was provided by the National Academy of Neuropsychology. Dr. Thames is currently supported by an NIH/NIMH Career Development Award (K-23 MH095661). NAN and NIH/NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. NR 63 TC 20 Z9 20 U1 3 U2 46 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 EI 1873-6327 J9 ADDICT BEHAV JI Addict. Behav. PD MAY PY 2014 VL 39 IS 5 BP 994 EP 999 DI 10.1016/j.addbeh.2014.01.019 PG 6 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA AG7QH UT WOS:000335612400026 PM 24556155 ER PT J AU Lu, LY Krumholz, HM Tu, JV Ross, JS Ko, DT Jackevicius, CA AF Lu, Lingyun Krumholz, Harlan M. Tu, Jack V. Ross, Joseph S. Ko, Dennis T. Jackevicius, Cynthia A. TI Impact of the ENHANCE Trial on the use of ezetimibe in the United States and Canada SO AMERICAN HEART JOURNAL LA English DT Article ID CARDIOVASCULAR-DISEASE; SIMVASTATIN; PREVENTION; THERAPY; RECOMMENDATIONS; DYSLIPIDEMIA; PUBLICATION; DIAGNOSIS; OUTCOMES; ONTARIO AB Background We previously found that the use of ezetimibe increased rapidly with different patterns between the United States (US) and Canada prior to the landmark Ezetimibe and Simvastatin in Hypercholesterolemia Enhance Atherosclerosis Regression (ENHANCE) trial, which was reported in January 2008, and failed to show that the drug slowed the progression of atherosclerosis. What is not known is how practice in the 2 countries changed after the ENHANCE trial. We examined ezetimibe use trends in the US and Canada before and after the reporting of the ENHANCE trial. Methods We conducted a population-based, retrospective, time-series analysis using the data collected by IMS Health in the US and CompuScript in Canada from January 1, 2002, to December 31, 2009. The main outcome measure was monthly number of prescriptions for ezetimibe-containing products. Results The monthly number of ezetimibe prescriptions/100,000 population rose from 6 to 1,082 in the US from November 2002 to January 2008, then significantly declined to 572/100,000 population by December 2009 after the release of the ENHANCE trial, a decrease of 47.1% (P < .001). In contrast, in Canada, use continuously rose from 2 to 495/100,000 population from June 2003 to December 2009 (P = .2). United States expenditures totaled $2.24 billion in 2009. Conclusions Ezetimibe remains commonly used in both the US and Canada. Ezetimibe use has decreased in the US post-ENHANCE, whereas use has gradually but steadily increased in Canada. The diverging patterns of ezetimibe use in the US and Canada require further investigation, as they reveal that a common evidence base is eliciting very different utilization patterns in neighboring countries. C1 [Lu, Lingyun; Jackevicius, Cynthia A.] Western Univ Hlth Sci, Coll Pharm, Dept Pharm Practice & Adm, Pomona, CA 91766 USA. [Lu, Lingyun; Jackevicius, Cynthia A.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Krumholz, Harlan M.] Yale Univ, Dept Med, Sect Cardiovasc Med, New Haven, CT 06520 USA. [Krumholz, Harlan M.; Ross, Joseph S.] Yale Univ, Yale New Haven Hosp, Sch Med, Ctr Outcomes Res & Evaluat, New Haven, CT USA. [Krumholz, Harlan M.] Yale Univ, Dept Epidemiol & Publ Hlth, Sect Hlth Policy & Adm, New Haven, CT 06520 USA. [Krumholz, Harlan M.] Robert Wood Johnson Clin Scholars Program, New Haven, CT USA. [Tu, Jack V.; Ko, Dennis T.; Jackevicius, Cynthia A.] Inst Clin Evaluat Sci, Toronto, ON, Canada. [Tu, Jack V.; Ko, Dennis T.; Jackevicius, Cynthia A.] Univ Toronto, Fac Med, Dept Hlth Policy Management & Evaluat, Toronto, ON, Canada. [Tu, Jack V.; Ko, Dennis T.] Univ Toronto, Sunnybrook Hlth Sci Ctr, Schulich Heart Ctr, Div Cardiol, Toronto, ON, Canada. [Ross, Joseph S.] Yale Univ, Dept Med, Gen Internal Med Sect, New Haven, CT 06520 USA. [Jackevicius, Cynthia A.] Univ Hlth Network, Toronto, ON, Canada. RP Jackevicius, CA (reprint author), Western Univ Hlth Sci, Coll Pharm, 309 E Second St, Pomona, CA 91766 USA. EM cjackevicius@westernu.edu FU College of Pharmacy of Western University of Health Sciences, Pomona, CA; Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute [U01-HL105270]; Heart and Stroke Foundation of Ontario, Toronto, Ontario; National Institute on Aging [K08 AG032886]; American Federation of Aging Research through the Paul B. Beeson Career Development Award Program; Heart and Stroke Foundation of Ontario; Ontario Ministry of Health and Long-Term Care, Toronto, Ontario FX This study was funded in part by the College of Pharmacy of Western University of Health Sciences, Pomona, CA, and in part by a Canadian Institutes of Health Research team grant in cardiovascular outcomes research to the Canadian Cardiovascular Outcomes Research Team. Neither funding source had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Dr Krumholz is chair of a cardiac scientific advisory board for UnitedHealth and supported by grant U01-HL105270 (Center for Cardiovascular Outcomes Research at Yale University) from the National Heart, Lung, and Blood Institute. Drs Krumholz and Ross receive support from Medtronic, Inc, to develop methods of clinical trial data sharing; from the Centers of Medicare and Medicaid Services to develop and maintain performance measures that are used for public reporting; and from the Food and Drug Administration to develop methods for postmarket surveillance of medical devices. Dr Tu is supported by a Canada Research Chair in Health Services Research and by a Career Investigator award of the Heart and Stroke Foundation of Ontario, Toronto, Ontario. Dr Ross is currently supported by the National Institute on Aging (K08 AG032886) and by the American Federation of Aging Research through the Paul B. Beeson Career Development Award Program. Dr Ko is supported by a Clinician Scientist (Phase II) Award from the Heart and Stroke Foundation of Ontario. The Institute for Clinical Evaluative Sciences is supported by an operating grant from the Ontario Ministry of Health and Long-Term Care, Toronto, Ontario. NR 30 TC 10 Z9 10 U1 0 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-8703 EI 1097-5330 J9 AM HEART J JI Am. Heart J. PD MAY PY 2014 VL 167 IS 5 AR 683 DI 10.1016/j.ahj.2014.01.014 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AG5GP UT WOS:000335447800008 PM 24766978 ER PT J AU Hernandez, J Tarbox, L Anstead, G Dyer, C AF Hernandez, Judith Tarbox, Lauren Anstead, Gregory Dyer, Christopher TI TENOFOVIR RELATED ACUTE INTERSTITIAL NEPHRITIS: A CASE SERIES SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of the National-Kidney-Foundation (NKF) CY APR 22-26, 2014 CL Las Vegas, NV SP Natl Kidney Fdn C1 Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. South Texas Vet Hlth Care Syst, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAY PY 2014 VL 63 IS 5 MA 147 BP A55 EP A55 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA AG5JZ UT WOS:000335456600149 ER PT J AU Nassar, T Tarbox, L Hernandez, J Dyer, C AF Nassar, Tareq Tarbox, Lauren Hernandez, Judith Dyer, Christopher TI PHYSICAL ACTIVITY AMONGST VETERANS WITH ESRD: PERCEPTIONS AND BARRIERS SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of the National-Kidney-Foundation (NKF) CY APR 22-26, 2014 CL Las Vegas, NV SP Natl Kidney Fdn C1 Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. South Texas Vet Hlth Care Syst, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAY PY 2014 VL 63 IS 5 MA 251 BP A81 EP A81 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA AG5JZ UT WOS:000335456600253 ER PT J AU Rohatgi, R Gentile, D Cancel-Santiago, R Gharitza, R Rindt, J Post, J He, JC Malina, J Langhoff, E AF Rohatgi, Rajeev Gentile, Denise Cancel-Santiago, Rosemarie Gharitza, Retha Rindt, John Post, James He, John Cijiang Malina, Joanne Langhoff, Erik TI TELENEPHROLOGY: A MODEL OF PATIENT CENTERED CARE SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of the National-Kidney-Foundation (NKF) CY APR 22-26, 2014 CL Las Vegas, NV SP Natl Kidney Fdn C1 James J Peters VAMC, Bronx, NY USA. Hudson Valley VAMC, Castle Point, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAY PY 2014 VL 63 IS 5 MA 307 BP A95 EP A95 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA AG5JZ UT WOS:000335456600309 ER PT J AU Wong, RM Ianculescu, I Sharma, S Gage, DL Olevsky, OM Kotova, S Kostic, MN Grundfest, WS Hou, DM Cameron, RB AF Wong, Raymond M. Ianculescu, Irina Sharma, Sherven Gage, Diana L. Olevsky, Olga M. Kotova, Svetlana Kostic, Marko N. Grundfest, Warren S. Hou, Dongmei Cameron, Robert B. TI Immunotherapy for Malignant Pleural Mesothelioma Current Status and Future Prospects SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY LA English DT Review DE mesothelioma; immunotherapy; immunosuppression; multimodality ID T-REGULATORY CELLS; BETA GENE-TRANSFER; IMMUNE-RESPONSES; SURGICAL DEBULKING; ANTI-PD-1 ANTIBODY; ADVANCED MELANOMA; INTERFERON-BETA; TUMOR-CELLS; GM-CSF; THERAPY AB Malignant pleural mesothelioma (MPM) is a rare malignancy of the pleura that is frequently resistant to conventional therapies. Immunotherapy is a promising investigational approach for MPM that has shown some evidence of clinical benefit in select patients. However, tumor-induced immunosuppression is likely a major impediment to achieving optimal clinical responses to immunotherapeutic intervention. MPM contains a variable degree of infiltrating T-regulatory cells and M2 macrophages, which are believed to facilitate tumor evasion from the host immune system. Additional immunosuppressive factors identified in other human tumor types, such as tumor-associated programmed death ligand-1 expression, may be relevant for investigation in MPM. Conventional cytoreductive therapies, such as radiation, chemotherapy, and surgery, may play a critical role in successful immunotherapeutic strategies by ablating intratumoral and/or systemic immunosuppressive factors, thus creating a host environment more amenable to immunotherapy. This article reviews the immunotherapeutic approachesbeing evaluated in patientswithMPM and discusses howimmunotherapymight be rationally combinedwith conventional tumor cytoreductive therapies for this disease. C1 [Wong, Raymond M.; Ianculescu, Irina] Pacific Heart Lung & Blood Inst, Pacific Meso Ctr, Los Angeles, CA 90025 USA. [Sharma, Sherven] Vet Affairs Greater Los Angeles Healthcare Syst, Dept Med Pulm & Crit Care, Los Angeles, CA USA. [Gage, Diana L.] Vet Affairs Greater Los Angeles Healthcare Syst, Dept Radiat Oncol, Los Angeles, CA USA. [Kotova, Svetlana; Cameron, Robert B.] Vet Affairs Greater Los Angeles Healthcare Syst, Div Thorac Surg, Los Angeles, CA USA. [Olevsky, Olga M.] Univ Calif Los Angeles, Dept Hematol & Oncol, Los Angeles, CA USA. [Kostic, Marko N.; Grundfest, Warren S.] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA USA. [Hou, Dongmei; Cameron, Robert B.] Univ Calif Los Angeles, Div Thorac Surg, Los Angeles, CA USA. [Hou, Dongmei; Cameron, Robert B.] Univ Calif Los Angeles, Comprehens Mesothelioma Program, Los Angeles, CA USA. RP Wong, RM (reprint author), Pacific Heart Lung & Blood Inst, Pacific Meso Ctr, 10780 Santa Monica Blvd 101, Los Angeles, CA 90025 USA. EM rwong@phlbi.org NR 48 TC 7 Z9 7 U1 0 U2 4 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1044-1549 EI 1535-4989 J9 AM J RESP CELL MOL JI Am. J. Respir. Cell Mol. Biol. PD MAY PY 2014 VL 50 IS 5 BP 870 EP 875 DI 10.1165/rcmb.2013-0472TR PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System GA AG8DB UT WOS:000335647900009 PM 24450537 ER PT J AU George, MS Raman, R Benedek, DM Pelic, CG Grammer, GG Stokes, KT Schmidt, M Spiegel, C DeAlmeida, N Beaver, KL Borckardt, JJ Sun, XY Jain, S Stein, MB AF George, Mark S. Raman, Rema Benedek, David M. Pelic, Christopher G. Grammer, Geoffrey G. Stokes, Karen T. Schmidt, Matthew Spiegel, Chad DeAlmeida, Nancy Beaver, Kathryn L. Borckardt, Jeffrey J. Sun, Xiaoying Jain, Sonia Stein, Murray B. TI A Two-site Pilot Randomized 3 Day Trial of High Dose Left Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) for Suicidal Inpatients SO BRAIN STIMULATION LA English DT Article DE TMS; Transcranial; Suicide; Prefrontal; Magnetic ID LEARNED HELPLESSNESS; RESISTANT DEPRESSION; BEHAVIORAL-CONTROL; MOTOR THRESHOLD; HEALTHY-ADULTS; PAIN; CORTEX; LITHIUM; PERCEPTION; PREVENTION AB Background: Suicide attempts and completed suicides are common, yet there are no proven acute medication or device treatments for treating a suicidal crisis. Repeated daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) for 4-6 weeks is a new FDA-approved treatment for acute depression. Some open-label rTMS studies have found rapid reductions in suicidality. Design: This study tests whether a high dose of rTMS to suicidal inpatients is feasible and safe, and also whether this higher dosing might rapidly improve suicidal thinking. This prospective, 2-site, randomized, active sham-controlled (1: 1 randomization) design incorporated 9 sessions of rTMS over 3 days as adjunctive to usual inpatient suicidality treatment. The setting was two inpatient military hospital wards (one VA, the other DOD). Patients: Research staff screened approximately 377 inpatients, yielding 41 adults admitted for suicidal crisis. Because of the funding source, all patients also had either post-traumatic stress disorder, mild traumatic brain injury, or both. TMS methods: Repetitive TMS (rTMS) was delivered to the left prefrontal cortex with a figure-eight solid core coil at 120% motor threshold, 10 Hertz (Hz), 5 second (s) train duration, 10 s intertrain interval for 30 minutes (6000 pulses) 3 times daily for 3 days (total 9 sessions; 54,000 stimuli). Sham rTMS used a similar coil that contained a metal insert blocking the magnetic field and utilized electrodes on the scalp, which delivered a matched somatosensory sensation. Main outcome measure: Primary outcomes were the daily change in severity of suicidal thinking as measured by the Beck Scale of Suicidal Ideation (SSI) administered at baseline and then daily, as well as subjective visual analog scale measures before and after each TMS session. Mixed model repeated measures (MMRM) analysis was performed on modified intent to treat (mITT) and completer populations. Results: This intense schedule of rTMS with suicidal inpatients was feasible and safe. Minimal side effects occurred, none differing by arm, and the 3-day retention rate was 88%. No one died of suicide within the 6 month followup. From the mITT analyses, SSI scores declined rapidly over the 3 days for both groups (sham change -15.3 points, active change -15.4 points), with a trend for more rapid decline on the first day with active rTMS (sham change -6.4 points, active -10.7 points, P = 0.12). This decline was more pronounced in the completers subgroup [sham change -5.9 (95% CI: -10.1, -1.7), active -13 points (95% CI: -18.7, -7.4); P = 0.054]. Subjective ratings of 'being bothered by thoughts of suicide' declined non- significantly more with active rTMS than with sham at the end of 9 sessions of treatment in the mITT analysis [sham change 31.9 (95% CI: 41.7, 22.0), active change 42.5 (95% CI: 53.8, 31.2); P = 0.17]. There was a significant decrease in the completers sample [sham change -24.9 (95% CI: -34.4, -15.3), active change -43.8 (95% CI: -57.2, -30.3); P = 0.028]. Conclusions: Delivering high doses of left prefrontal rTMS over three days (54,000 stimuli) to suicidal inpatients is possible and safe, with few side effects and no worsening of suicidal thinking. The suggestions of a rapid anti-suicide effect (day 1 SSI data, Visual Analogue Scale data over the 3 days) need to be tested for replication in a larger sample. (C) 2014 Elsevier Inc. All rights reserved. C1 [George, Mark S.; Pelic, Christopher G.; Schmidt, Matthew; Beaver, Kathryn L.; Borckardt, Jeffrey J.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [George, Mark S.; Pelic, Christopher G.; Schmidt, Matthew; Beaver, Kathryn L.; Borckardt, Jeffrey J.] Med Univ S Carolina, Dept Psychiat, Brain Stimulat Div, Charleston, SC 29425 USA. [Benedek, David M.; Grammer, Geoffrey G.; Spiegel, Chad; DeAlmeida, Nancy] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Raman, Rema; Stokes, Karen T.; Sun, Xiaoying; Jain, Sonia; Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. RP George, MS (reprint author), MUSC, IOP, 502 N,67 President St, Charleston, SC 29425 USA. EM georgem@musc.edu FU U.S. Army Medical Research and Materiel Command (USAMRMC); DOD INTRuST [W81XWH-08-2-0159] FX Funded by U.S. Army Medical Research and Materiel Command (USAMRMC).; Funding mechanism: Contract # W81XWH-08-2-0159, DOD INTRuST. NR 59 TC 16 Z9 18 U1 7 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1935-861X EI 1876-4754 J9 BRAIN STIMUL JI Brain Stimul. PD MAY-JUN PY 2014 VL 7 IS 3 BP 421 EP 431 DI 10.1016/j.brs.2014.03.006 PG 11 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AG9KZ UT WOS:000335739400012 PM 24731434 ER PT J AU Chahine, G Short, B Spicer, K Schmidt, M Burns, C Atoui, M George, MS Sackeim, HA Nahas, Z AF Chahine, George Short, Baron Spicer, Ken Schmidt, Matthew Bu